MRPL40 cDNA ORF clone, Homo sapiens(human)

Gene
Clones
gRNAs

Summary

Gene Symbol	MRPL40
Entrez Gene ID	64976
Full Name	mitochondrial ribosomal protein L40
Synonyms	L40mt,MRP-L22,MRP-L40,MRPL22,NLVCF,URIM
General protein information	Preferred Names mitochondrial ribosomal protein L40 Names 39S ribosomal protein L40, mitochondrial mitochondrial large ribosomal subunit protein mL40 nuclear localization signal-containing protein deleted in velocardiofacial syndrome up-regulated in metastasis
Gene Type	protein-coding
Organism	Homo sapiens(human)
Genome	Chromosome: 22 Map Location: 22q11.21
Summary	Mammalian mitochondrial ribosomal proteins are encoded by nuclear genes and help in protein synthesis within the mitochondrion. Mitochondrial ribosomes (mitoribosomes) consist of a small 28S subunit and a large 39S subunit. They have an estimated 75% protein to rRNA composition compared to prokaryotic ribosomes, where this ratio is reversed. Another difference between mammalian mitoribosomes and prokaryotic ribosomes is that the latter contain a 5S rRNA. Among different species, the proteins comprising the mitoribosome differ greatly in sequence, and sometimes in biochemical properties, which prevents easy recognition by sequence homology. This gene encodes a 39S subunit protein. Deletions in this gene may contribute to the etiology of velo-cardio-facial syndrome and DiGeorge syndrome. [provided by RefSeq, Jul 2008].
Disorder MIM:	605089

mRNA and Protein(s)

mRNA	Protein	Name
NM_001318151.1	NP_001305080.1	39S ribosomal protein L40, mitochondrial isoform 2
NM_001318152.1	NP_001305081.1	39S ribosomal protein L40, mitochondrial isoform 2
NM_003776.3	NP_003767.2	39S ribosomal protein L40, mitochondrial isoform 1
NM_003776.2	NP_003767.2	39S ribosomal protein L40, mitochondrial
NM_001318151.2	NP_001305080.1	39S ribosomal protein L40, mitochondrial isoform 2

Pathways from BioSystems

Homologies

Homo sapiens (human)	MRPL40	NP_003767.2
Bos taurus (cattle)	MRPL40	XP_005218368.1
Mus musculus (house mouse)	Mrpl40	NP_035052.2
Danio rerio (zebrafish)	mrpl40	NP_001004612.1
	MRPL40	XP_001104649.1
Canis lupus familiaris (dog)	MRPL40	XP_534762.3
Gallus gallus (chicken)	MRPL40	XP_003642247.2
Drosophila melanogaster (fruit fly)	mRpL40	NP_524318.1
Pan troglodytes (chimpanzee)	MRPL40	XP_525523.2
Anopheles gambiae (African malaria mosquito)	AgaP_AGAP000110	XP_311037.3
Caenorhabditis elegans (roundworm)	mrpl-40	NP_497138.1
Xenopus tropicalis (tropical clawed frog)	mrpl40	NP_001016249.1
Rattus norvegicus (Norway rat)	Mrpl40	NP_001020036.1

Gene Ontology
Bibliography

Related articles in PubMed

Structures of the human mitochondrial ribosome in native states of assembly.
Brown A, Rathore S, Kimanius D, Aibara S, Bai XC, Rorbach J, Amunts A, Ramakrishnan V
Nature structural & molecular biology24(10)866-869(2017 Oct)

Mitochondrial Citrate Transporter-dependent Metabolic Signature in the 22q11.2 Deletion Syndrome.
Napoli E, Tassone F, Wong S, Angkustsiri K, Simon TJ, Song G, Giulivi C
The Journal of biological chemistry290(38)23240-53(2015 Sep)

Structure of the large ribosomal subunit from human mitochondria.
Brown A, Amunts A, Bai XC, Sugimoto Y, Edwards PC, Murshudov G, Scheres SHW, Ramakrishnan V
Science (New York, N.Y.)346(6210)718-722(2014 Nov)

Mitochondria "fuel" breast cancer metabolism: fifteen markers of mitochondrial biogenesis label epithelial cancer cells, but are excluded from adjacent stromal cells.
Sotgia F, Whitaker-Menezes D, Martinez-Outschoorn UE, Salem AF, Tsirigos A, Lamb R, Sneddon S, Hulit J, Howell A, Lisanti MP
Cell cycle (Georgetown, Tex.)11(23)4390-401(2012 Dec)

The mRNA-bound proteome and its global occupancy profile on protein-coding transcripts.
Baltz AG, Munschauer M, Schwanh?usser B, Vasile A, Murakawa Y, Schueler M, Youngs N, Penfold-Brown D, Drew K, Milek M, Wyler E, Bonneau R, Selbach M, Dieterich C, Landthaler M
Molecular cell46(5)674-90(2012 Jun)

GeneRIFs: Gene References Into Functions What's a GeneRIF?

Observational study of gene-disease association. (HuGE Navigator)
Title: Genetic variants in nuclear-encoded mitochondrial genes influence AIDS progression.

The following MRPL40 gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the MRPL40 cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1⁺/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.

***CloneID	Accession No.	Definition	**Vector	*Turnaround time	Price (USD)
OHu30132	NM_003776.3 Latest version!	Homo sapiens mitochondrial ribosomal protein L40 (MRPL40), transcript variant 1, mRNA.	pcDNA3.1-C-(k)DYK or customized vector	in pcDNA3.1-C-(k)DYK	$49.50-$69.30 $99.00
OHu53658	NM_001318152.1 Latest version!	Homo sapiens mitochondrial ribosomal protein L40 (MRPL40), transcript variant 3, mRNA.	pcDNA3.1-C-(k)DYK or customized vector	5-7	$69.30 $99.00
OHu53658	NM_001318151.2 Latest version!	Homo sapiens mitochondrial ribosomal protein L40 (MRPL40), transcript variant 2, mRNA.	pcDNA3.1-C-(k)DYK or customized vector	5-7	$69.30 $99.00
View Old Accession Versions >>
OHu30132	NM_003776.2	Homo sapiens mitochondrial ribosomal protein L40 (MRPL40), mRNA.	pcDNA3.1-C-(k)DYK or customized vector	in pcDNA3.1-C-(k)DYK	$49.50-$69.30 $99.00
OHu53658	NM_001318151.1	Homo sapiens mitochondrial ribosomal protein L40 (MRPL40), transcript variant 2, mRNA.	pcDNA3.1-C-(k)DYK or customized vector	5-7	$69.30 $99.00
Hide Old Accession Versions >>

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** GenScript guarantees 100% sequence accuracy of all synthetic DNA constructs we deliver, but we do not guarantee protein expression in your experimental system. Protein expression is influenced by many factors that may vary between experiments or laboratories. In addition, please pay attention to the signal peptide, propeptide and transit peptide in target ORF, which may affect the choice of vector (N/C terminal tag vector).

***One clone ID might be correlated to multiple accession numbers, which share the same CDS sequence.

Reference Sequences (Refseq)

MRPL40 ( NM_003776.3 ) cDNA ORF clone, Homo sapiens(human) -> NP_003767.2 Homo sapiens mitochondrial ribosomal protein L40 (MRPL40), transcript variant 1, mRNA.

Price & Availability↑

CloneID	OHu30132
Clone ID Related Accession (Same CDS sequence)	NM_003776.3 , NM_003776.2
Accession Version	NM_003776.3 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 621bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-09-24
Organism	Homo sapiens(human)
Product	39S ribosomal protein L40, mitochondrial isoform 1
Comment	Comment: REVIEWED REFSEQ: This record has been curated by NCBI staff. The reference sequence was derived from AK123768.1, AC000079.1, BC009707.1 and BM974354.1. On Dec 24, 2015 this sequence version replaced NM_003776.2. Transcript Variant: This variant (1) represents the longest transcript and encodes the longer isoform (1). Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: AK123768.1, SRR1163655.23740.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA1965299, SAMEA1966682 [ECO:0000348] ##Evidence-Data-END## ##RefSeq-Attributes-START## gene product(s) localized to mito. :: reported by MitoCarta RefSeq Select criteria :: based on conservation, expression, longest protein ##RefSeq-Attributes-END## COMPLETENESS: complete on the 3' end.

ATGACGGCCT CCGTGCTGCG AAGTATCTCG CTAGCCCTGC GCCCGACTAG CGGGCTTCTG 
GGAACTTGGC AGACGCAGCT TAGAGAGACT CACCAGCGAG CGTCATTGTT GTCTTTCTGG 
GAACTCATTC CCATGAGATC AGAACCTCTT CGAAAAAAGA AGAAGGTAGA TCCTAAAAAA 
GACCAAGAAG CAAAGGAGCG CTTGAAAAGG AAGATCCGAA AACTGGAAAA GGCTACTCAA 
GAGCTAATTC CTATTGAAGA TTTTATTACC CCTCTAAAGT TCTTGGATAA AGCAAGAGAG 
CGGCCTCAGG TGGAGCTCAC CTTTGAGGAG ACTGAGAGGA GAGCTCTGCT TCTGAAGAAG 
TGGTCCTTGT ACAAGCAGCA AGAGCGTAAG ATGGAGAGGG ACACCATCAG GGCTATGCTA 
GAAGCCCAGC AGGAAGCTCT GGAGGAACTG CAACTGGAAT CCCCGAAGCT CCATGCTGAG 
GCCATCAAGC GGGATCCTAA CCTGTTCCCC TTTGAGAAGG AAGGGCCACA TTACACACCA 
CCGATCCCTA ACTACCAACC CCCTGAAGGC AGGTACAATG ACATCACCAA GGTGTACACA 
CAAGTGGAGT TTAAGAGATA G

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_003767.2
CDS	654..1274
Translation	MTASVLRSISLALRPTSGLLGTWQTQLRETHQRASLLSFWELIPMRSEPLRKKKKVDPKKDQEAKERLKRKIRKLEKATQELIPIEDFITPLKFLDKARERPQVELTFEETERRALLLKKWSLYKQQERKMERDTIRAMLEAQQEALEELQLESPKLHAEAIKRDPNLFPFEKEGPHYTPPIPNYQPPEGRYNDITKVYTQVEFKR

Target ORF information:

RefSeq Version	NM_003776.3
Organism	Homo sapiens(human)
Definition	Homo sapiens mitochondrial ribosomal protein L40 (MRPL40), transcript variant 1, mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_003776.3

ORF Insert Sequence:

ATGACGGCCT CCGTGCTGCG AAGTATCTCG CTAGCCCTGC GCCCGACTAG CGGGCTTCTG 
GGAACTTGGC AGACGCAGCT TAGAGAGACT CACCAGCGAG CGTCATTGTT GTCTTTCTGG 
GAACTCATTC CCATGAGATC AGAACCTCTT CGAAAAAAGA AGAAGGTAGA TCCTAAAAAA 
GACCAAGAAG CAAAGGAGCG CTTGAAAAGG AAGATCCGAA AACTGGAAAA GGCTACTCAA 
GAGCTAATTC CTATTGAAGA TTTTATTACC CCTCTAAAGT TCTTGGATAA AGCAAGAGAG 
CGGCCTCAGG TGGAGCTCAC CTTTGAGGAG ACTGAGAGGA GAGCTCTGCT TCTGAAGAAG 
TGGTCCTTGT ACAAGCAGCA AGAGCGTAAG ATGGAGAGGG ACACCATCAG GGCTATGCTA 
GAAGCCCAGC AGGAAGCTCT GGAGGAACTG CAACTGGAAT CCCCGAAGCT CCATGCTGAG 
GCCATCAAGC GGGATCCTAA CCTGTTCCCC TTTGAGAAGG AAGGGCCACA TTACACACCA 
CCGATCCCTA ACTACCAACC CCCTGAAGGC AGGTACAATG ACATCACCAA GGTGTACACA 
CAAGTGGAGT TTAAGAGATA G

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

MRPL40 ( NM_003776.2 ) cDNA ORF clone, Homo sapiens(human) -> NP_003767.2 Homo sapiens mitochondrial ribosomal protein L40 (MRPL40), mRNA.

Price & Availability↑

CloneID	OHu30132
Clone ID Related Accession (Same CDS sequence)	NM_003776.3 , NM_003776.2
Accession Version	NM_003776.2	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 621bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2015-03-14
Organism	Homo sapiens(Human)
Product	39S ribosomal protein L40, mitochondrial
Comment

ATGACGGCCT CCGTGCTGCG AAGTATCTCG CTAGCCCTGC GCCCGACTAG CGGGCTTCTG 
GGAACTTGGC AGACGCAGCT TAGAGAGACT CACCAGCGAG CGTCATTGTT GTCTTTCTGG 
GAACTCATTC CCATGAGATC AGAACCTCTT CGAAAAAAGA AGAAGGTAGA TCCTAAAAAA 
GACCAAGAAG CAAAGGAGCG CTTGAAAAGG AAGATCCGAA AACTGGAAAA GGCTACTCAA 
GAGCTAATTC CTATTGAAGA TTTTATTACC CCTCTAAAGT TCTTGGATAA AGCAAGAGAG 
CGGCCTCAGG TGGAGCTCAC CTTTGAGGAG ACTGAGAGGA GAGCTCTGCT TCTGAAGAAG 
TGGTCCTTGT ACAAGCAGCA AGAGCGTAAG ATGGAGAGGG ACACCATCAG GGCTATGCTA 
GAAGCCCAGC AGGAAGCTCT GGAGGAACTG CAACTGGAAT CCCCGAAGCT CCATGCTGAG 
GCCATCAAGC GGGATCCTAA CCTGTTCCCC TTTGAGAAGG AAGGGCCACA TTACACACCA 
CCGATCCCTA ACTACCAACC CCCTGAAGGC AGGTACAATG ACATCACCAA GGTGTACACA 
CAAGTGGAGT TTAAGAGATA G

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_003767.2
Translation	MTASVLRSISLALRPTSGLLGTWQTQLRETHQRASLLSFWELIPMRSEPLRKKKKVDPKKDQEAKERLKRKIRKLEKATQELIPIEDFITPLKFLDKARERPQVELTFEETERRALLLKKWSLYKQQERKMERDTIRAMLEAQQEALEELQLESPKLHAEAIKRDPNLFPFEKEGPHYTPPIPNYQPPEGRYNDITKVYTQVEFKR

Target ORF information:

RefSeq Version	NM_003776.2
Organism	Homo sapiens(Human)
Definition	Homo sapiens mitochondrial ribosomal protein L40 (MRPL40), mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_003776.2

ORF Insert Sequence:

ATGACGGCCT CCGTGCTGCG AAGTATCTCG CTAGCCCTGC GCCCGACTAG CGGGCTTCTG 
GGAACTTGGC AGACGCAGCT TAGAGAGACT CACCAGCGAG CGTCATTGTT GTCTTTCTGG 
GAACTCATTC CCATGAGATC AGAACCTCTT CGAAAAAAGA AGAAGGTAGA TCCTAAAAAA 
GACCAAGAAG CAAAGGAGCG CTTGAAAAGG AAGATCCGAA AACTGGAAAA GGCTACTCAA 
GAGCTAATTC CTATTGAAGA TTTTATTACC CCTCTAAAGT TCTTGGATAA AGCAAGAGAG 
CGGCCTCAGG TGGAGCTCAC CTTTGAGGAG ACTGAGAGGA GAGCTCTGCT TCTGAAGAAG 
TGGTCCTTGT ACAAGCAGCA AGAGCGTAAG ATGGAGAGGG ACACCATCAG GGCTATGCTA 
GAAGCCCAGC AGGAAGCTCT GGAGGAACTG CAACTGGAAT CCCCGAAGCT CCATGCTGAG 
GCCATCAAGC GGGATCCTAA CCTGTTCCCC TTTGAGAAGG AAGGGCCACA TTACACACCA 
CCGATCCCTA ACTACCAACC CCCTGAAGGC AGGTACAATG ACATCACCAA GGTGTACACA 
CAAGTGGAGT TTAAGAGATA G

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

MRPL40 ( NM_001318151.1 ) cDNA ORF clone, Homo sapiens(human) -> NP_001305080.1 Homo sapiens mitochondrial ribosomal protein L40 (MRPL40), transcript variant 2, mRNA.

Price & Availability↑

CloneID	OHu53658
Clone ID Related Accession (Same CDS sequence)	NM_001318151.1 , NM_001318152.1 , NM_001318151.2
Accession Version	NM_001318151.1	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 489bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2018-08-10
Organism	Homo sapiens(human)
Product	39S ribosomal protein L40, mitochondrial isoform 2
Comment	Comment: REVIEWED REFSEQ: This record has been curated by NCBI staff. The reference sequence was derived from CN409565.1, BX382916.2 and BM974354.1. On Dec 24, 2015 this sequence version replaced XM_005261267.2. Transcript Variant: This variant (2) differs in the 5' UTR and initiates translation at a downstream start codon compared to variant 1. The encoded isoform (2) has a shorter N-terminus and lacks the predicted mitochondrial transit peptide compared to isoform 1. Both variants 2 and 3 encode the same isoform (2). Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: SRR1163657.315520.1, SRR1163655.599470.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA1965299, SAMEA1966682 [ECO:0000348] ##Evidence-Data-END## ##RefSeq-Attributes-START## gene product(s) localized to mito. :: reported by MitoCarta ##RefSeq-Attributes-END## COMPLETENESS: complete on the 3' end.

ATGAGATCAG AACCTCTTCG AAAAAAGAAG AAGGTAGATC CTAAAAAAGA CCAAGAAGCA 
AAGGAGCGCT TGAAAAGGAA GATCCGAAAA CTGGAAAAGG CTACTCAAGA GCTAATTCCT 
ATTGAAGATT TTATTACCCC TCTAAAGTTC TTGGATAAAG CAAGAGAGCG GCCTCAGGTG 
GAGCTCACCT TTGAGGAGAC TGAGAGGAGA GCTCTGCTTC TGAAGAAGTG GTCCTTGTAC 
AAGCAGCAAG AGCGTAAGAT GGAGAGGGAC ACCATCAGGG CTATGCTAGA AGCCCAGCAG 
GAAGCTCTGG AGGAACTGCA ACTGGAATCC CCGAAGCTCC ATGCTGAGGC CATCAAGCGG 
GATCCTAACC TGTTCCCCTT TGAGAAGGAA GGGCCACATT ACACACCACC GATCCCTAAC 
TACCAACCCC CTGAAGGCAG GTACAATGAC ATCACCAAGG TGTACACACA AGTGGAGTTT 
AAGAGATAG

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_001305080.1
CDS	436..924
Translation	MRSEPLRKKKKVDPKKDQEAKERLKRKIRKLEKATQELIPIEDFITPLKFLDKARERPQVELTFEETERRALLLKKWSLYKQQERKMERDTIRAMLEAQQEALEELQLESPKLHAEAIKRDPNLFPFEKEGPHYTPPIPNYQPPEGRYNDITKVYTQVEFKR

Target ORF information:

RefSeq Version	NM_001318151.1
Organism	Homo sapiens(human)
Definition	Homo sapiens mitochondrial ribosomal protein L40 (MRPL40), transcript variant 2, mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_001318151.1

ORF Insert Sequence:

ATGAGATCAG AACCTCTTCG AAAAAAGAAG AAGGTAGATC CTAAAAAAGA CCAAGAAGCA 
AAGGAGCGCT TGAAAAGGAA GATCCGAAAA CTGGAAAAGG CTACTCAAGA GCTAATTCCT 
ATTGAAGATT TTATTACCCC TCTAAAGTTC TTGGATAAAG CAAGAGAGCG GCCTCAGGTG 
GAGCTCACCT TTGAGGAGAC TGAGAGGAGA GCTCTGCTTC TGAAGAAGTG GTCCTTGTAC 
AAGCAGCAAG AGCGTAAGAT GGAGAGGGAC ACCATCAGGG CTATGCTAGA AGCCCAGCAG 
GAAGCTCTGG AGGAACTGCA ACTGGAATCC CCGAAGCTCC ATGCTGAGGC CATCAAGCGG 
GATCCTAACC TGTTCCCCTT TGAGAAGGAA GGGCCACATT ACACACCACC GATCCCTAAC 
TACCAACCCC CTGAAGGCAG GTACAATGAC ATCACCAAGG TGTACACACA AGTGGAGTTT 
AAGAGATAG

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

MRPL40 ( NM_001318152.1 ) cDNA ORF clone, Homo sapiens(human) -> NP_001305081.1 Homo sapiens mitochondrial ribosomal protein L40 (MRPL40), transcript variant 3, mRNA.

Price & Availability↑

CloneID	OHu53658
Clone ID Related Accession (Same CDS sequence)	NM_001318151.1 , NM_001318152.1 , NM_001318151.2
Accession Version	NM_001318152.1 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 489bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-09-24
Organism	Homo sapiens(human)
Product	39S ribosomal protein L40, mitochondrial isoform 2
Comment	Comment: REVIEWED REFSEQ: This record has been curated by NCBI staff. The reference sequence was derived from BP309678.1 and BM974354.1. Transcript Variant: This variant (3) differs in the 5' UTR and initiates translation at a downstream start codon compared to variant 1. The encoded isoform (2) has a shorter N-terminus and lacks the predicted mitochondrial transit peptide compared to isoform 1. Both variants 2 and 3 encode the same isoform (2). Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: BM974354.1, BG497554.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA1965299, SAMEA1966682 [ECO:0000348] ##Evidence-Data-END## ##RefSeq-Attributes-START## gene product(s) localized to mito. :: reported by MitoCarta ##RefSeq-Attributes-END## COMPLETENESS: complete on the 3' end.

ATGAGATCAG AACCTCTTCG AAAAAAGAAG AAGGTAGATC CTAAAAAAGA CCAAGAAGCA 
AAGGAGCGCT TGAAAAGGAA GATCCGAAAA CTGGAAAAGG CTACTCAAGA GCTAATTCCT 
ATTGAAGATT TTATTACCCC TCTAAAGTTC TTGGATAAAG CAAGAGAGCG GCCTCAGGTG 
GAGCTCACCT TTGAGGAGAC TGAGAGGAGA GCTCTGCTTC TGAAGAAGTG GTCCTTGTAC 
AAGCAGCAAG AGCGTAAGAT GGAGAGGGAC ACCATCAGGG CTATGCTAGA AGCCCAGCAG 
GAAGCTCTGG AGGAACTGCA ACTGGAATCC CCGAAGCTCC ATGCTGAGGC CATCAAGCGG 
GATCCTAACC TGTTCCCCTT TGAGAAGGAA GGGCCACATT ACACACCACC GATCCCTAAC 
TACCAACCCC CTGAAGGCAG GTACAATGAC ATCACCAAGG TGTACACACA AGTGGAGTTT 
AAGAGATAG

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_001305081.1
CDS	406..894
Translation	MRSEPLRKKKKVDPKKDQEAKERLKRKIRKLEKATQELIPIEDFITPLKFLDKARERPQVELTFEETERRALLLKKWSLYKQQERKMERDTIRAMLEAQQEALEELQLESPKLHAEAIKRDPNLFPFEKEGPHYTPPIPNYQPPEGRYNDITKVYTQVEFKR

Target ORF information:

RefSeq Version	NM_001318152.1
Organism	Homo sapiens(human)
Definition	Homo sapiens mitochondrial ribosomal protein L40 (MRPL40), transcript variant 3, mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_001318152.1

ORF Insert Sequence:

ATGAGATCAG AACCTCTTCG AAAAAAGAAG AAGGTAGATC CTAAAAAAGA CCAAGAAGCA 
AAGGAGCGCT TGAAAAGGAA GATCCGAAAA CTGGAAAAGG CTACTCAAGA GCTAATTCCT 
ATTGAAGATT TTATTACCCC TCTAAAGTTC TTGGATAAAG CAAGAGAGCG GCCTCAGGTG 
GAGCTCACCT TTGAGGAGAC TGAGAGGAGA GCTCTGCTTC TGAAGAAGTG GTCCTTGTAC 
AAGCAGCAAG AGCGTAAGAT GGAGAGGGAC ACCATCAGGG CTATGCTAGA AGCCCAGCAG 
GAAGCTCTGG AGGAACTGCA ACTGGAATCC CCGAAGCTCC ATGCTGAGGC CATCAAGCGG 
GATCCTAACC TGTTCCCCTT TGAGAAGGAA GGGCCACATT ACACACCACC GATCCCTAAC 
TACCAACCCC CTGAAGGCAG GTACAATGAC ATCACCAAGG TGTACACACA AGTGGAGTTT 
AAGAGATAG

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

MRPL40 ( NM_001318151.2 ) cDNA ORF clone, Homo sapiens(human) -> NP_001305080.1 Homo sapiens mitochondrial ribosomal protein L40 (MRPL40), transcript variant 2, mRNA.

Price & Availability↑

CloneID	OHu53658
Clone ID Related Accession (Same CDS sequence)	NM_001318151.1 , NM_001318152.1 , NM_001318151.2
Accession Version	NM_001318151.2 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 489bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-09-28
Organism	Homo sapiens(human)
Product	39S ribosomal protein L40, mitochondrial isoform 2
Comment	Comment: REVIEWED REFSEQ: This record has been curated by NCBI staff. The reference sequence was derived from CN409565.1, BX382916.2 and BM974354.1. On Jun 2, 2019 this sequence version replaced NM_001318151.1. Transcript Variant: This variant (2) differs in the 5' UTR and initiates translation at a downstream start codon compared to variant 1. The encoded isoform (2) has a shorter N-terminus and lacks the predicted mitochondrial transit peptide compared to isoform 1. Both variants 2 and 3 encode the same isoform (2). Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: SRR1163657.315520.1, CD368925.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA1965299, SAMEA1966682 [ECO:0000348] ##Evidence-Data-END## ##RefSeq-Attributes-START## gene product(s) localized to mito. :: reported by MitoCarta ##RefSeq-Attributes-END## COMPLETENESS: complete on the 3' end.

ATGAGATCAG AACCTCTTCG AAAAAAGAAG AAGGTAGATC CTAAAAAAGA CCAAGAAGCA 
AAGGAGCGCT TGAAAAGGAA GATCCGAAAA CTGGAAAAGG CTACTCAAGA GCTAATTCCT 
ATTGAAGATT TTATTACCCC TCTAAAGTTC TTGGATAAAG CAAGAGAGCG GCCTCAGGTG 
GAGCTCACCT TTGAGGAGAC TGAGAGGAGA GCTCTGCTTC TGAAGAAGTG GTCCTTGTAC 
AAGCAGCAAG AGCGTAAGAT GGAGAGGGAC ACCATCAGGG CTATGCTAGA AGCCCAGCAG 
GAAGCTCTGG AGGAACTGCA ACTGGAATCC CCGAAGCTCC ATGCTGAGGC CATCAAGCGG 
GATCCTAACC TGTTCCCCTT TGAGAAGGAA GGGCCACATT ACACACCACC GATCCCTAAC 
TACCAACCCC CTGAAGGCAG GTACAATGAC ATCACCAAGG TGTACACACA AGTGGAGTTT 
AAGAGATAG

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_001305080.1
CDS	395..883
Translation	MRSEPLRKKKKVDPKKDQEAKERLKRKIRKLEKATQELIPIEDFITPLKFLDKARERPQVELTFEETERRALLLKKWSLYKQQERKMERDTIRAMLEAQQEALEELQLESPKLHAEAIKRDPNLFPFEKEGPHYTPPIPNYQPPEGRYNDITKVYTQVEFKR

Target ORF information:

RefSeq Version	NM_001318151.2
Organism	Homo sapiens(human)
Definition	Homo sapiens mitochondrial ribosomal protein L40 (MRPL40), transcript variant 2, mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_001318151.2

ORF Insert Sequence:

ATGAGATCAG AACCTCTTCG AAAAAAGAAG AAGGTAGATC CTAAAAAAGA CCAAGAAGCA 
AAGGAGCGCT TGAAAAGGAA GATCCGAAAA CTGGAAAAGG CTACTCAAGA GCTAATTCCT 
ATTGAAGATT TTATTACCCC TCTAAAGTTC TTGGATAAAG CAAGAGAGCG GCCTCAGGTG 
GAGCTCACCT TTGAGGAGAC TGAGAGGAGA GCTCTGCTTC TGAAGAAGTG GTCCTTGTAC 
AAGCAGCAAG AGCGTAAGAT GGAGAGGGAC ACCATCAGGG CTATGCTAGA AGCCCAGCAG 
GAAGCTCTGG AGGAACTGCA ACTGGAATCC CCGAAGCTCC ATGCTGAGGC CATCAAGCGG 
GATCCTAACC TGTTCCCCTT TGAGAAGGAA GGGCCACATT ACACACCACC GATCCCTAAC 
TACCAACCCC CTGAAGGCAG GTACAATGAC ATCACCAAGG TGTACACACA AGTGGAGTTT 
AAGAGATAG

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

PubMed

Structures of the human mitochondrial ribosome in native states of assembly.
Nature structural & molecular biology24(10)866-869(2017 Oct)
Brown A,Rathore S,Kimanius D,Aibara S,Bai XC,Rorbach J,Amunts A,Ramakrishnan V

Mitochondrial Citrate Transporter-dependent Metabolic Signature in the 22q11.2 Deletion Syndrome.
The Journal of biological chemistry290(38)23240-53(2015 Sep)
Napoli E,Tassone F,Wong S,Angkustsiri K,Simon TJ,Song G,Giulivi C

Structure of the large ribosomal subunit from human mitochondria.
Science (New York, N.Y.)346(6210)718-722(2014 Nov)
Brown A,Amunts A,Bai XC,Sugimoto Y,Edwards PC,Murshudov G,Scheres SHW,Ramakrishnan V

Mitochondria "fuel" breast cancer metabolism: fifteen markers of mitochondrial biogenesis label epithelial cancer cells, but are excluded from adjacent stromal cells.
Cell cycle (Georgetown, Tex.)11(23)4390-401(2012 Dec)
Sotgia F,Whitaker-Menezes D,Martinez-Outschoorn UE,Salem AF,Tsirigos A,Lamb R,Sneddon S,Hulit J,Howell A,Lisanti MP

The mRNA-bound proteome and its global occupancy profile on protein-coding transcripts.
Molecular cell46(5)674-90(2012 Jun)
Baltz AG,Munschauer M,Schwanh?usser B,Vasile A,Murakawa Y,Schueler M,Youngs N,Penfold-Brown D,Drew K,Milek M,Wyler E,Bonneau R,Selbach M,Dieterich C,Landthaler M

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MRPL40 cDNA ORF clone, Homo sapiens(human)

Gene

Clones

gRNAs

Related articles in PubMed

Target ORF information:

Target ORF information:

ORF Insert Sequence:

Target ORF information:

Target ORF information:

ORF Insert Sequence:

Target ORF information:

Target ORF information:

ORF Insert Sequence:

Target ORF information:

Target ORF information:

ORF Insert Sequence:

Target ORF information:

Target ORF information:

ORF Insert Sequence:

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