PCDH20 cDNA ORF clone, Homo sapiens(human)

Gene
Clones
gRNAs

Summary

Gene Symbol	PCDH20
Entrez Gene ID	64881
Full Name	protocadherin 20
Synonyms	PCDH13
General protein information	Preferred Names protocadherin 20 Names protocadherin-20 protocadherin 13
Gene Type	protein-coding
Organism	Homo sapiens(human)
Genome	Chromosome: 13 Map Location: 13q21.2
Summary	This gene belongs to the protocadherin gene family, a subfamily of the cadherin superfamily. This gene encodes a protein which contains 6 extracellular cadherin domains, a transmembrane domain and a cytoplasmic tail differing from those of the classical cadherins. Although its specific function is undetermined, the cadherin-related neuronal receptor is thought to play a role in the establishment and function of specific cell-cell connections in the brain. [provided by RefSeq, Jul 2008].
Disorder MIM:	614449

mRNA and Protein(s)

mRNA	Protein	Name
NM_022843.3	NP_073754.2	protocadherin-20 precursor
XM_017020708.1	XP_016876197.1	protocadherin-20 isoform X1

Pathways from BioSystems

Homologies

Homo sapiens (human)	PCDH20	NP_073754.2
Canis lupus familiaris (dog)	LOC100686939	XP_005634010.1
Xenopus tropicalis (tropical clawed frog)	pcdh20	NP_001093700.1
Rattus norvegicus (Norway rat)	Pcdh20	NP_001100750.1
Gallus gallus (chicken)	PCDH20	XP_004938713.1
Pan troglodytes (chimpanzee)	PCDH20	XP_003314208.1
	PCDH20	XP_001086611.1
Bos taurus (cattle)	PCDH20	NP_001193160.1
Mus musculus (house mouse)	Pcdh20	NP_848800.3
Danio rerio (zebrafish)	pcdh20	XP_001345843.3

Gene Ontology
Bibliography

Related articles in PubMed

Decreased expression of protocadherin 20 is associated with poor prognosis in hepatocellular carcinoma.
Wu Y, Zheng S, Yao J, Li M, Yang G, Zhang N, Zhang S, Zhong B
Oncotarget8(2)3018-3028(2017 Jan)

Genome-wide association analysis on normal hearing function identifies PCDH20 and SLC28A3 as candidates for hearing function and loss.
Vuckovic D, Dawson S, Scheffer DI, Rantanen T, Morgan A, Di Stazio M, Vozzi D, Nutile T, Concas MP, Biino G, Nolan L, Bahl A, Loukola A, Viljanen A, Davis A, Ciullo M, Corey DP, Pirastu M, Gasparini P, Girotto G
Human molecular genetics24(19)5655-64(2015 Oct)

Protocadherin20 Acts as a Tumor Suppressor Gene: Epigenetic Inactivation in Nasopharyngeal Carcinoma.
Chen T, Long B, Ren G, Xiang T, Li L, Wang Z, He Y, Zeng Q, Hong S, Hu G
Journal of cellular biochemistry116(8)1766-75(2015 Aug)

PCDH20 functions as a tumour-suppressor gene through antagonizing the Wnt/?-catenin signalling pathway in hepatocellular carcinoma.
Lv J, Zhu P, Yang Z, Li M, Zhang X, Cheng J, Chen X, Lu F
Journal of viral hepatitis22(2)201-11(2015 Feb)

Genome-wide association study of clinical dimensions of schizophrenia: polygenic effect on disorganized symptoms.
Fanous AH, Zhou B, Aggen SH, Bergen SE, Amdur RL, Duan J, Sanders AR, Shi J, Mowry BJ, Olincy A, Amin F, Cloninger CR, Silverman JM, Buccola NG, Byerley WF, Black DW, Freedman R, Dudbridge F, Holmans PA, Ripke S, Gejman PV, Kendler KS, Levinson DF,
The American journal of psychiatry169(12)1309-17(2012 Dec)

GeneRIFs: Gene References Into Functions What's a GeneRIF?

Genome-wide association analysis on normal hearing function identifies PCDH20 and SLC28A3 as good candidates for modulatory genes in the auditory system. [meta-analysis]
Title: Genome-wide association analysis on normal hearing function identifies PCDH20 and SLC28A3 as candidates for hearing function and loss.

Study shows that PCDH20 expression is downregulated in nasopharyngeal carcinoma cells (NPC) and identified it as a functional tumor suppressor and an important antagonist of Wnt/beta-catenin signaling and EMT, with frequent epigenetic inactivation in NPC.
Title: Protocadherin20 Acts as a Tumor Suppressor Gene: Epigenetic Inactivation in Nasopharyngeal Carcinoma.

In conclusion, these data here strongly suggested that PCDH20 may act as a candidate tumour suppressor in hepatocellular carcinoma.
Title: PCDH20 functions as a tumour-suppressor gene through antagonizing the Wnt/?-catenin signalling pathway in hepatocellular carcinoma.

The following PCDH20 gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the PCDH20 cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1⁺/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.

***CloneID	Accession No.	Definition	**Vector	*Turnaround time	Price (USD)	Select
OHu24332	NM_022843.3 Latest version!	Homo sapiens protocadherin 20 (PCDH20), mRNA.	pcDNA3.1-C-(k)DYK or customized vector	12-14	$475.30 $679.00
OHu24332	XM_017020708.1 Latest version!	Homo sapiens protocadherin 20 (PCDH20), transcript variant X1, mRNA.	pcDNA3.1-C-(k)DYK or customized vector	12-14	$475.30 $679.00

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** You may select a custom vector to replace pcDNA3.1+/C-(K)DYK after clone is added to cart.

** GenScript guarantees 100% sequence accuracy of all synthetic DNA constructs we deliver, but we do not guarantee protein expression in your experimental system. Protein expression is influenced by many factors that may vary between experiments or laboratories. In addition, please pay attention to the signal peptide, propeptide and transit peptide in target ORF, which may affect the choice of vector (N/C terminal tag vector).

***One clone ID might be correlated to multiple accession numbers, which share the same CDS sequence.

Reference Sequences (Refseq)

PCDH20 ( NM_022843.3 ) cDNA ORF clone, Homo sapiens(human) -> NP_073754.2 Homo sapiens protocadherin 20 (PCDH20), mRNA.

Price & Availability↑

CloneID	OHu24332
Clone ID Related Accession (Same CDS sequence)	NM_022843.3 , XM_017020708.1
Accession Version	NM_022843.3 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 2856bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-12-27
Organism	Homo sapiens(human)
Product	protocadherin-20 precursor
Comment	Comment: VALIDATED REFSEQ: This record has undergone validation or preliminary review. The reference sequence was derived from AK289924.1, AK094680.1, AL592490.8, AL162575.15 and AA040057.1. On Jun 12, 2008 this sequence version replaced NM_022843.2. Sequence Note: The RefSeq transcript and protein were derived from genomic sequence to make the sequence consistent with the reference genome assembly. The genomic coordinates used for the transcript record were based on alignments. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: AF169693.1, SRR1660809.222766.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA2158188, SAMN03267763 [ECO:0000348] ##Evidence-Data-END## ##RefSeq-Attributes-START## RefSeq Select criteria :: based on single protein-coding transcript ##RefSeq-Attributes-END## COMPLETENESS: complete on the 3' end.

ATGCGCGGCC GAGGGAATGC GCGCAGCTCA CAGGCCCTGG GAGTGAGCTG GTGCCCGGCG 
ACCTGGCACC CGCGCCTGGA TATGGGGCGT CTACATCGTC CCAGGAGCAG CACCAGCTAC 
AGGAACCTGC CGCATCTGTT TCTGTTTTTC CTCTTCGTGG GACCCTTCAG CTGCCTCGGG 
AGTTACAGCC GGGCCACCGA GCTTCTGTAC AGCCTAAACG AGGGACTACC CGCGGGGGTG 
CTCATCGGCA GCCTGGCCGA GGACCTGCGG CTGCTGCCCA GGTCTGCAGG GAGGCCGGAC 
CCGCAGTCGC AGCTGCCAGA GCGCACCGGT GCTGAGTGGA ACCCCCCTCT CTCCTTCAGC 
CTGGCCTCCC GGGGACTGAG TGGCCAGTAC GTGACCCTAG ACAACCGCTC TGGGGAGCTG 
CACACTTCAG CTCAGGAGAT CGACAGGGAG GCCCTGTGTG TTGAAGGGGG TGGAGGGACT 
GCGTGGAGCG GCAGCGTTTC CATCTCCTCC TCTCCTTCTG ACTCTTGTCT TTTGCTGCTG 
GATGTGCTTG TCCTGCCTCA GGAATACTTC AGGTTTGTGA AGGTGAAGAT CGCCATCAGA 
GACATCAATG ACAACGCCCC GCAGTTCCCT GTTTCCCAGA TCTCGGTGTG GGTCCCGGAA 
AATGCACCTG TAAACACCCG ACTGGCCATA GAGCATCCTG CTGTGGACCC AGATGTAGGC 
ATTAATGGGG TACAGACCTA TCGCTTACTG GACTACCATG GTATGTTCAC CCTGGACGTG 
GAGGAGAATG AGAATGGGGA GCGCACCCCC TACCTAATTG TCATGGGTGC TTTGGACAGG 
GAAACCCAGG ACCAGTATGT GAGCATCATC ATAGCTGAGG ATGGTGGGTC TCCACCACTT 
TTGGGCAGTG CCACTCTCAC CATTGGCATC AGTGACATTA ATGACAATTG CCCTCTCTTC 
ACAGACTCAC AAATCAATGT CACTGTGTAT GGGAATGCTA CAGTGGGCAC CCCAATTGCA 
GCTGTCCAGG CTGTGGATAA AGACTTGGGG ACCAATGCTC AAATTACTTA TTCTTACAGT 
CAGAAAGTTC CACAAGCATC TAAGGATTTA TTTCACCTGG ATGAAAACAC TGGAGTCATT 
AAACTTTTCA GTAAGATTGG AGGAAGTGTT CTGGAGTCCC ACAAGCTCAC CATCCTTGCT 
AATGGACCAG GCTGCATCCC TGCTGTAATC ACTGCTCTTG TGTCCATTAT TAAAGTTATT 
TTCAGACCCC CTGAAATTGT CCCTCGTTAC ATAGCAAACG AGATAGATGG TGTGGTTTAT 
CTGAAAGAAC TGGAACCCGT TAACACTCCC ATTGCGTTTT TCACCATAAG AGATCCAGAA 
GGTAAATACA AGGTTAACTG CTACCTGGAT GGTGAAGGGC CGTTTAGGTT ATCACCTTAC 
AAACCATACA ATAATGAATA TTTACTAGAG ACCACAAAAC CTATGGACTA TGAGCTACAG 
CAGTTCTATG AAGTAGCTGT GGTGGCTTGG AACTCTGAGG GATTTCATGT CAAAAGGGTC 
ATTAAAGTGC AACTTTTAGA TGACAATGAT AATGCTCCAA TTTTCCTTCA ACCCTTAATA 
GAACTAACCA TCGAAGAGAA CAACTCACCC AATGCCTTTT TGACTAAGCT GTATGCTACA 
GATGCCGACA GCGAGGAGAG AGGCCAAGTT TCATATTTTC TGGGACCTGA TGCTCCATCA 
TATTTTTCCT TAGACAGTGT CACAGGAATT CTGACAGTTT CTACTCAGCT GGACCGAGAA 
GAGAAAGAAA AGTACAGATA CACTGTCAGA GCTGTTGACT GTGGGAAGCC ACCCAGAGAA 
TCAGTAGCCA CTGTGGCCCT CACAGTGTTG GATAAAAATG ACAACAGTCC TCGGTTTATC 
AACAAGGACT TCAGCTTTTT TGTGCCTGAA AACTTTCCAG GCTATGGTGA GATTGGAGTA 
ATTAGTGTAA CAGATGCTGA CGCTGGACGA AATGGATGGG TCGCCCTCTC TGTGGTGAAC 
CAGAGTGATA TTTTTGTCAT AGATACAGGA AAGGGTATGC TGAGGGCTAA AGTCTCTTTG 
GACAGAGAGC AGCAAAGCTC CTATACTTTG TGGGTTGAAG CTGTTGATGG GGGTGAGCCT 
GCCCTCTCCT CTACAGCAAA AATCACAATT CTCCTTCTAG ATATCAATGA CAACCCTCCT 
CTTGTTTTGT TTCCTCAGTC TAATATGTCT TATCTGTTAG TACTGCCTTC TACTCTGCCA 
GGCTCCCCGG TTACAGAAGT CTATGCTGTC GACAAAGACA CAGGCATGAA TGCTGTCATA 
GCTTACAGCA TCATAGGGAG AAGAGGTCCT AGGCCTGAGT CCTTCAGGAT TGACCCTAAA 
ACTGGCAACA TTACTTTGGA AGAGGCATTG CTGCAGACAG ATTATGGGCT CCATCGCTTA 
CTGGTGAAAG TGAGTGATCA TGGTTATCCC GAGCCTCTCC ACTCCACAGT CATGGTGAAC 
CTATTTGTCA ATGACACTGT CAGTAATGAG AGTTACATTG AGAGTCTTTT AAGAAAAGAA 
CCAGAGATTA ATATAGAGGA GAAAGAACCA CAAATCTCAA TAGAACCGAC TCATAGGAAG 
GTAGAATCTG TGTCTTGTAT GCCCACCTTA GTAGCTCTGT CTGTAATAAG CTTGGGTTCC 
ATCACACTGG TCACAGGGAT GGGCATATAC ATCTGTTTAA GGAAAGGGGA AAAGCATCCC 
AGGGAAGATG AAAATTTGGA AGTACAGATT CCACTGAAAG GAAAAATTGA CTTGCATATG 
CGAGAGAGAA AGCCAATGGA TATTTCTAAT ATTTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_073754.2
CDS	365..3220
Translation	MRGRGNARSSQALGVSWCPATWHPRLDMGRLHRPRSSTSYRNLPHLFLFFLFVGPFSCLGSYSRATELLYSLNEGLPAGVLIGSLAEDLRLLPRSAGRPDPQSQLPERTGAEWNPPLSFSLASRGLSGQYVTLDNRSGELHTSAQEIDREALCVEGGGGTAWSGSVSISSSPSDSCLLLLDVLVLPQEYFRFVKVKIAIRDINDNAPQFPVSQISVWVPENAPVNTRLAIEHPAVDPDVGINGVQTYRLLDYHGMFTLDVEENENGERTPYLIVMGALDRETQDQYVSIIIAEDGGSPPLLGSATLTIGISDINDNCPLFTDSQINVTVYGNATVGTPIAAVQAVDKDLGTNAQITYSYSQKVPQASKDLFHLDENTGVIKLFSKIGGSVLESHKLTILANGPGCIPAVITALVSIIKVIFRPPEIVPRYIANEIDGVVYLKELEPVNTPIAFFTIRDPEGKYKVNCYLDGEGPFRLSPYKPYNNEYLLETTKPMDYELQQFYEVAVVAWNSEGFHVKRVIKVQLLDDNDNAPIFLQPLIELTIEENNSPNAFLTKLYATDADSEERGQVSYFLGPDAPSYFSLDSVTGILTVSTQLDREEKEKYRYTVRAVDCGKPPRESVATVALTVLDKNDNSPRFINKDFSFFVPENFPGYGEIGVISVTDADAGRNGWVALSVVNQSDIFVIDTGKGMLRAKVSLDREQQSSYTLWVEAVDGGEPALSSTAKITILLLDINDNPPLVLFPQSNMSYLLVLPSTLPGSPVTEVYAVDKDTGMNAVIAYSIIGRRGPRPESFRIDPKTGNITLEEALLQTDYGLHRLLVKVSDHGYPEPLHSTVMVNLFVNDTVSNESYIESLLRKEPEINIEEKEPQISIEPTHRKVESVSCMPTLVALSVISLGSITLVTGMGIYICLRKGEKHPREDENLEVQIPLKGKIDLHMRERKPMDISNI

Target ORF information:

RefSeq Version	NM_022843.3
Organism	Homo sapiens(human)
Definition	Homo sapiens protocadherin 20 (PCDH20), mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_022843.3

ORF Insert Sequence:

ATGCGCGGCC GAGGGAATGC GCGCAGCTCA CAGGCCCTGG GAGTGAGCTG GTGCCCGGCG 
ACCTGGCACC CGCGCCTGGA TATGGGGCGT CTACATCGTC CCAGGAGCAG CACCAGCTAC 
AGGAACCTGC CGCATCTGTT TCTGTTTTTC CTCTTCGTGG GACCCTTCAG CTGCCTCGGG 
AGTTACAGCC GGGCCACCGA GCTTCTGTAC AGCCTAAACG AGGGACTACC CGCGGGGGTG 
CTCATCGGCA GCCTGGCCGA GGACCTGCGG CTGCTGCCCA GGTCTGCAGG GAGGCCGGAC 
CCGCAGTCGC AGCTGCCAGA GCGCACCGGT GCTGAGTGGA ACCCCCCTCT CTCCTTCAGC 
CTGGCCTCCC GGGGACTGAG TGGCCAGTAC GTGACCCTAG ACAACCGCTC TGGGGAGCTG 
CACACTTCAG CTCAGGAGAT CGACAGGGAG GCCCTGTGTG TTGAAGGGGG TGGAGGGACT 
GCGTGGAGCG GCAGCGTTTC CATCTCCTCC TCTCCTTCTG ACTCTTGTCT TTTGCTGCTG 
GATGTGCTTG TCCTGCCTCA GGAATACTTC AGGTTTGTGA AGGTGAAGAT CGCCATCAGA 
GACATCAATG ACAACGCCCC GCAGTTCCCT GTTTCCCAGA TCTCGGTGTG GGTCCCGGAA 
AATGCACCTG TAAACACCCG ACTGGCCATA GAGCATCCTG CTGTGGACCC AGATGTAGGC 
ATTAATGGGG TACAGACCTA TCGCTTACTG GACTACCATG GTATGTTCAC CCTGGACGTG 
GAGGAGAATG AGAATGGGGA GCGCACCCCC TACCTAATTG TCATGGGTGC TTTGGACAGG 
GAAACCCAGG ACCAGTATGT GAGCATCATC ATAGCTGAGG ATGGTGGGTC TCCACCACTT 
TTGGGCAGTG CCACTCTCAC CATTGGCATC AGTGACATTA ATGACAATTG CCCTCTCTTC 
ACAGACTCAC AAATCAATGT CACTGTGTAT GGGAATGCTA CAGTGGGCAC CCCAATTGCA 
GCTGTCCAGG CTGTGGATAA AGACTTGGGG ACCAATGCTC AAATTACTTA TTCTTACAGT 
CAGAAAGTTC CACAAGCATC TAAGGATTTA TTTCACCTGG ATGAAAACAC TGGAGTCATT 
AAACTTTTCA GTAAGATTGG AGGAAGTGTT CTGGAGTCCC ACAAGCTCAC CATCCTTGCT 
AATGGACCAG GCTGCATCCC TGCTGTAATC ACTGCTCTTG TGTCCATTAT TAAAGTTATT 
TTCAGACCCC CTGAAATTGT CCCTCGTTAC ATAGCAAACG AGATAGATGG TGTGGTTTAT 
CTGAAAGAAC TGGAACCCGT TAACACTCCC ATTGCGTTTT TCACCATAAG AGATCCAGAA 
GGTAAATACA AGGTTAACTG CTACCTGGAT GGTGAAGGGC CGTTTAGGTT ATCACCTTAC 
AAACCATACA ATAATGAATA TTTACTAGAG ACCACAAAAC CTATGGACTA TGAGCTACAG 
CAGTTCTATG AAGTAGCTGT GGTGGCTTGG AACTCTGAGG GATTTCATGT CAAAAGGGTC 
ATTAAAGTGC AACTTTTAGA TGACAATGAT AATGCTCCAA TTTTCCTTCA ACCCTTAATA 
GAACTAACCA TCGAAGAGAA CAACTCACCC AATGCCTTTT TGACTAAGCT GTATGCTACA 
GATGCCGACA GCGAGGAGAG AGGCCAAGTT TCATATTTTC TGGGACCTGA TGCTCCATCA 
TATTTTTCCT TAGACAGTGT CACAGGAATT CTGACAGTTT CTACTCAGCT GGACCGAGAA 
GAGAAAGAAA AGTACAGATA CACTGTCAGA GCTGTTGACT GTGGGAAGCC ACCCAGAGAA 
TCAGTAGCCA CTGTGGCCCT CACAGTGTTG GATAAAAATG ACAACAGTCC TCGGTTTATC 
AACAAGGACT TCAGCTTTTT TGTGCCTGAA AACTTTCCAG GCTATGGTGA GATTGGAGTA 
ATTAGTGTAA CAGATGCTGA CGCTGGACGA AATGGATGGG TCGCCCTCTC TGTGGTGAAC 
CAGAGTGATA TTTTTGTCAT AGATACAGGA AAGGGTATGC TGAGGGCTAA AGTCTCTTTG 
GACAGAGAGC AGCAAAGCTC CTATACTTTG TGGGTTGAAG CTGTTGATGG GGGTGAGCCT 
GCCCTCTCCT CTACAGCAAA AATCACAATT CTCCTTCTAG ATATCAATGA CAACCCTCCT 
CTTGTTTTGT TTCCTCAGTC TAATATGTCT TATCTGTTAG TACTGCCTTC TACTCTGCCA 
GGCTCCCCGG TTACAGAAGT CTATGCTGTC GACAAAGACA CAGGCATGAA TGCTGTCATA 
GCTTACAGCA TCATAGGGAG AAGAGGTCCT AGGCCTGAGT CCTTCAGGAT TGACCCTAAA 
ACTGGCAACA TTACTTTGGA AGAGGCATTG CTGCAGACAG ATTATGGGCT CCATCGCTTA 
CTGGTGAAAG TGAGTGATCA TGGTTATCCC GAGCCTCTCC ACTCCACAGT CATGGTGAAC 
CTATTTGTCA ATGACACTGT CAGTAATGAG AGTTACATTG AGAGTCTTTT AAGAAAAGAA 
CCAGAGATTA ATATAGAGGA GAAAGAACCA CAAATCTCAA TAGAACCGAC TCATAGGAAG 
GTAGAATCTG TGTCTTGTAT GCCCACCTTA GTAGCTCTGT CTGTAATAAG CTTGGGTTCC 
ATCACACTGG TCACAGGGAT GGGCATATAC ATCTGTTTAA GGAAAGGGGA AAAGCATCCC 
AGGGAAGATG AAAATTTGGA AGTACAGATT CCACTGAAAG GAAAAATTGA CTTGCATATG 
CGAGAGAGAA AGCCAATGGA TATTTCTAAT ATTTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

PCDH20 ( XM_017020708.1 ) cDNA ORF clone, Homo sapiens(human) -> XP_016876197.1 Homo sapiens protocadherin 20 (PCDH20), transcript variant X1, mRNA.

Price & Availability↑

CloneID	OHu24332
Clone ID Related Accession (Same CDS sequence)	NM_022843.3 , XM_017020708.1
Accession Version	XM_017020708.1 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 2856bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2016-06-05
Organism	Homo sapiens(human)
Product	protocadherin-20 isoform X1
Comment	Comment: MODEL REFSEQ: This record is predicted by automated computational analysis. This record is derived from a genomic sequence (NC_000013.11) annotated using gene prediction method: Gnomon, supported by mRNA and EST evidence. Also see: Documentation of NCBI's Annotation Process ##Genome-Annotation-Data-START## Annotation Provider :: NCBI Annotation Status :: Full annotation Annotation Version :: Homo sapiens Annotation Release 108 Annotation Pipeline :: NCBI eukaryotic genome annotation pipeline Annotation Software Version :: 7.0 Annotation Method :: Best-placed RefSeq; Gnomon Features Annotated :: Gene; mRNA; CDS; ncRNA ##Genome-Annotation-Data-END##

ATGCGCGGCC GAGGGAATGC GCGCAGCTCA CAGGCCCTGG GAGTGAGCTG GTGCCCGGCG 
ACCTGGCACC CGCGCCTGGA TATGGGGCGT CTACATCGTC CCAGGAGCAG CACCAGCTAC 
AGGAACCTGC CGCATCTGTT TCTGTTTTTC CTCTTCGTGG GACCCTTCAG CTGCCTCGGG 
AGTTACAGCC GGGCCACCGA GCTTCTGTAC AGCCTAAACG AGGGACTACC CGCGGGGGTG 
CTCATCGGCA GCCTGGCCGA GGACCTGCGG CTGCTGCCCA GGTCTGCAGG GAGGCCGGAC 
CCGCAGTCGC AGCTGCCAGA GCGCACCGGT GCTGAGTGGA ACCCCCCTCT CTCCTTCAGC 
CTGGCCTCCC GGGGACTGAG TGGCCAGTAC GTGACCCTAG ACAACCGCTC TGGGGAGCTG 
CACACTTCAG CTCAGGAGAT CGACAGGGAG GCCCTGTGTG TTGAAGGGGG TGGAGGGACT 
GCGTGGAGCG GCAGCGTTTC CATCTCCTCC TCTCCTTCTG ACTCTTGTCT TTTGCTGCTG 
GATGTGCTTG TCCTGCCTCA GGAATACTTC AGGTTTGTGA AGGTGAAGAT CGCCATCAGA 
GACATCAATG ACAACGCCCC GCAGTTCCCT GTTTCCCAGA TCTCGGTGTG GGTCCCGGAA 
AATGCACCTG TAAACACCCG ACTGGCCATA GAGCATCCTG CTGTGGACCC AGATGTAGGC 
ATTAATGGGG TACAGACCTA TCGCTTACTG GACTACCATG GTATGTTCAC CCTGGACGTG 
GAGGAGAATG AGAATGGGGA GCGCACCCCC TACCTAATTG TCATGGGTGC TTTGGACAGG 
GAAACCCAGG ACCAGTATGT GAGCATCATC ATAGCTGAGG ATGGTGGGTC TCCACCACTT 
TTGGGCAGTG CCACTCTCAC CATTGGCATC AGTGACATTA ATGACAATTG CCCTCTCTTC 
ACAGACTCAC AAATCAATGT CACTGTGTAT GGGAATGCTA CAGTGGGCAC CCCAATTGCA 
GCTGTCCAGG CTGTGGATAA AGACTTGGGG ACCAATGCTC AAATTACTTA TTCTTACAGT 
CAGAAAGTTC CACAAGCATC TAAGGATTTA TTTCACCTGG ATGAAAACAC TGGAGTCATT 
AAACTTTTCA GTAAGATTGG AGGAAGTGTT CTGGAGTCCC ACAAGCTCAC CATCCTTGCT 
AATGGACCAG GCTGCATCCC TGCTGTAATC ACTGCTCTTG TGTCCATTAT TAAAGTTATT 
TTCAGACCCC CTGAAATTGT CCCTCGTTAC ATAGCAAACG AGATAGATGG TGTGGTTTAT 
CTGAAAGAAC TGGAACCCGT TAACACTCCC ATTGCGTTTT TCACCATAAG AGATCCAGAA 
GGTAAATACA AGGTTAACTG CTACCTGGAT GGTGAAGGGC CGTTTAGGTT ATCACCTTAC 
AAACCATACA ATAATGAATA TTTACTAGAG ACCACAAAAC CTATGGACTA TGAGCTACAG 
CAGTTCTATG AAGTAGCTGT GGTGGCTTGG AACTCTGAGG GATTTCATGT CAAAAGGGTC 
ATTAAAGTGC AACTTTTAGA TGACAATGAT AATGCTCCAA TTTTCCTTCA ACCCTTAATA 
GAACTAACCA TCGAAGAGAA CAACTCACCC AATGCCTTTT TGACTAAGCT GTATGCTACA 
GATGCCGACA GCGAGGAGAG AGGCCAAGTT TCATATTTTC TGGGACCTGA TGCTCCATCA 
TATTTTTCCT TAGACAGTGT CACAGGAATT CTGACAGTTT CTACTCAGCT GGACCGAGAA 
GAGAAAGAAA AGTACAGATA CACTGTCAGA GCTGTTGACT GTGGGAAGCC ACCCAGAGAA 
TCAGTAGCCA CTGTGGCCCT CACAGTGTTG GATAAAAATG ACAACAGTCC TCGGTTTATC 
AACAAGGACT TCAGCTTTTT TGTGCCTGAA AACTTTCCAG GCTATGGTGA GATTGGAGTA 
ATTAGTGTAA CAGATGCTGA CGCTGGACGA AATGGATGGG TCGCCCTCTC TGTGGTGAAC 
CAGAGTGATA TTTTTGTCAT AGATACAGGA AAGGGTATGC TGAGGGCTAA AGTCTCTTTG 
GACAGAGAGC AGCAAAGCTC CTATACTTTG TGGGTTGAAG CTGTTGATGG GGGTGAGCCT 
GCCCTCTCCT CTACAGCAAA AATCACAATT CTCCTTCTAG ATATCAATGA CAACCCTCCT 
CTTGTTTTGT TTCCTCAGTC TAATATGTCT TATCTGTTAG TACTGCCTTC TACTCTGCCA 
GGCTCCCCGG TTACAGAAGT CTATGCTGTC GACAAAGACA CAGGCATGAA TGCTGTCATA 
GCTTACAGCA TCATAGGGAG AAGAGGTCCT AGGCCTGAGT CCTTCAGGAT TGACCCTAAA 
ACTGGCAACA TTACTTTGGA AGAGGCATTG CTGCAGACAG ATTATGGGCT CCATCGCTTA 
CTGGTGAAAG TGAGTGATCA TGGTTATCCC GAGCCTCTCC ACTCCACAGT CATGGTGAAC 
CTATTTGTCA ATGACACTGT CAGTAATGAG AGTTACATTG AGAGTCTTTT AAGAAAAGAA 
CCAGAGATTA ATATAGAGGA GAAAGAACCA CAAATCTCAA TAGAACCGAC TCATAGGAAG 
GTAGAATCTG TGTCTTGTAT GCCCACCTTA GTAGCTCTGT CTGTAATAAG CTTGGGTTCC 
ATCACACTGG TCACAGGGAT GGGCATATAC ATCTGTTTAA GGAAAGGGGA AAAGCATCCC 
AGGGAAGATG AAAATTTGGA AGTACAGATT CCACTGAAAG GAAAAATTGA CTTGCATATG 
CGAGAGAGAA AGCCAATGGA TATTTCTAAT ATTTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	XP_016876197.1
CDS	1801..4656
Translation	MRGRGNARSSQALGVSWCPATWHPRLDMGRLHRPRSSTSYRNLPHLFLFFLFVGPFSCLGSYSRATELLYSLNEGLPAGVLIGSLAEDLRLLPRSAGRPDPQSQLPERTGAEWNPPLSFSLASRGLSGQYVTLDNRSGELHTSAQEIDREALCVEGGGGTAWSGSVSISSSPSDSCLLLLDVLVLPQEYFRFVKVKIAIRDINDNAPQFPVSQISVWVPENAPVNTRLAIEHPAVDPDVGINGVQTYRLLDYHGMFTLDVEENENGERTPYLIVMGALDRETQDQYVSIIIAEDGGSPPLLGSATLTIGISDINDNCPLFTDSQINVTVYGNATVGTPIAAVQAVDKDLGTNAQITYSYSQKVPQASKDLFHLDENTGVIKLFSKIGGSVLESHKLTILANGPGCIPAVITALVSIIKVIFRPPEIVPRYIANEIDGVVYLKELEPVNTPIAFFTIRDPEGKYKVNCYLDGEGPFRLSPYKPYNNEYLLETTKPMDYELQQFYEVAVVAWNSEGFHVKRVIKVQLLDDNDNAPIFLQPLIELTIEENNSPNAFLTKLYATDADSEERGQVSYFLGPDAPSYFSLDSVTGILTVSTQLDREEKEKYRYTVRAVDCGKPPRESVATVALTVLDKNDNSPRFINKDFSFFVPENFPGYGEIGVISVTDADAGRNGWVALSVVNQSDIFVIDTGKGMLRAKVSLDREQQSSYTLWVEAVDGGEPALSSTAKITILLLDINDNPPLVLFPQSNMSYLLVLPSTLPGSPVTEVYAVDKDTGMNAVIAYSIIGRRGPRPESFRIDPKTGNITLEEALLQTDYGLHRLLVKVSDHGYPEPLHSTVMVNLFVNDTVSNESYIESLLRKEPEINIEEKEPQISIEPTHRKVESVSCMPTLVALSVISLGSITLVTGMGIYICLRKGEKHPREDENLEVQIPLKGKIDLHMRERKPMDISNI

Target ORF information:

RefSeq Version	XM_017020708.1
Organism	Homo sapiens(human)
Definition	Homo sapiens protocadherin 20 (PCDH20), transcript variant X1, mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

XM_017020708.1

ORF Insert Sequence:

ATGCGCGGCC GAGGGAATGC GCGCAGCTCA CAGGCCCTGG GAGTGAGCTG GTGCCCGGCG 
ACCTGGCACC CGCGCCTGGA TATGGGGCGT CTACATCGTC CCAGGAGCAG CACCAGCTAC 
AGGAACCTGC CGCATCTGTT TCTGTTTTTC CTCTTCGTGG GACCCTTCAG CTGCCTCGGG 
AGTTACAGCC GGGCCACCGA GCTTCTGTAC AGCCTAAACG AGGGACTACC CGCGGGGGTG 
CTCATCGGCA GCCTGGCCGA GGACCTGCGG CTGCTGCCCA GGTCTGCAGG GAGGCCGGAC 
CCGCAGTCGC AGCTGCCAGA GCGCACCGGT GCTGAGTGGA ACCCCCCTCT CTCCTTCAGC 
CTGGCCTCCC GGGGACTGAG TGGCCAGTAC GTGACCCTAG ACAACCGCTC TGGGGAGCTG 
CACACTTCAG CTCAGGAGAT CGACAGGGAG GCCCTGTGTG TTGAAGGGGG TGGAGGGACT 
GCGTGGAGCG GCAGCGTTTC CATCTCCTCC TCTCCTTCTG ACTCTTGTCT TTTGCTGCTG 
GATGTGCTTG TCCTGCCTCA GGAATACTTC AGGTTTGTGA AGGTGAAGAT CGCCATCAGA 
GACATCAATG ACAACGCCCC GCAGTTCCCT GTTTCCCAGA TCTCGGTGTG GGTCCCGGAA 
AATGCACCTG TAAACACCCG ACTGGCCATA GAGCATCCTG CTGTGGACCC AGATGTAGGC 
ATTAATGGGG TACAGACCTA TCGCTTACTG GACTACCATG GTATGTTCAC CCTGGACGTG 
GAGGAGAATG AGAATGGGGA GCGCACCCCC TACCTAATTG TCATGGGTGC TTTGGACAGG 
GAAACCCAGG ACCAGTATGT GAGCATCATC ATAGCTGAGG ATGGTGGGTC TCCACCACTT 
TTGGGCAGTG CCACTCTCAC CATTGGCATC AGTGACATTA ATGACAATTG CCCTCTCTTC 
ACAGACTCAC AAATCAATGT CACTGTGTAT GGGAATGCTA CAGTGGGCAC CCCAATTGCA 
GCTGTCCAGG CTGTGGATAA AGACTTGGGG ACCAATGCTC AAATTACTTA TTCTTACAGT 
CAGAAAGTTC CACAAGCATC TAAGGATTTA TTTCACCTGG ATGAAAACAC TGGAGTCATT 
AAACTTTTCA GTAAGATTGG AGGAAGTGTT CTGGAGTCCC ACAAGCTCAC CATCCTTGCT 
AATGGACCAG GCTGCATCCC TGCTGTAATC ACTGCTCTTG TGTCCATTAT TAAAGTTATT 
TTCAGACCCC CTGAAATTGT CCCTCGTTAC ATAGCAAACG AGATAGATGG TGTGGTTTAT 
CTGAAAGAAC TGGAACCCGT TAACACTCCC ATTGCGTTTT TCACCATAAG AGATCCAGAA 
GGTAAATACA AGGTTAACTG CTACCTGGAT GGTGAAGGGC CGTTTAGGTT ATCACCTTAC 
AAACCATACA ATAATGAATA TTTACTAGAG ACCACAAAAC CTATGGACTA TGAGCTACAG 
CAGTTCTATG AAGTAGCTGT GGTGGCTTGG AACTCTGAGG GATTTCATGT CAAAAGGGTC 
ATTAAAGTGC AACTTTTAGA TGACAATGAT AATGCTCCAA TTTTCCTTCA ACCCTTAATA 
GAACTAACCA TCGAAGAGAA CAACTCACCC AATGCCTTTT TGACTAAGCT GTATGCTACA 
GATGCCGACA GCGAGGAGAG AGGCCAAGTT TCATATTTTC TGGGACCTGA TGCTCCATCA 
TATTTTTCCT TAGACAGTGT CACAGGAATT CTGACAGTTT CTACTCAGCT GGACCGAGAA 
GAGAAAGAAA AGTACAGATA CACTGTCAGA GCTGTTGACT GTGGGAAGCC ACCCAGAGAA 
TCAGTAGCCA CTGTGGCCCT CACAGTGTTG GATAAAAATG ACAACAGTCC TCGGTTTATC 
AACAAGGACT TCAGCTTTTT TGTGCCTGAA AACTTTCCAG GCTATGGTGA GATTGGAGTA 
ATTAGTGTAA CAGATGCTGA CGCTGGACGA AATGGATGGG TCGCCCTCTC TGTGGTGAAC 
CAGAGTGATA TTTTTGTCAT AGATACAGGA AAGGGTATGC TGAGGGCTAA AGTCTCTTTG 
GACAGAGAGC AGCAAAGCTC CTATACTTTG TGGGTTGAAG CTGTTGATGG GGGTGAGCCT 
GCCCTCTCCT CTACAGCAAA AATCACAATT CTCCTTCTAG ATATCAATGA CAACCCTCCT 
CTTGTTTTGT TTCCTCAGTC TAATATGTCT TATCTGTTAG TACTGCCTTC TACTCTGCCA 
GGCTCCCCGG TTACAGAAGT CTATGCTGTC GACAAAGACA CAGGCATGAA TGCTGTCATA 
GCTTACAGCA TCATAGGGAG AAGAGGTCCT AGGCCTGAGT CCTTCAGGAT TGACCCTAAA 
ACTGGCAACA TTACTTTGGA AGAGGCATTG CTGCAGACAG ATTATGGGCT CCATCGCTTA 
CTGGTGAAAG TGAGTGATCA TGGTTATCCC GAGCCTCTCC ACTCCACAGT CATGGTGAAC 
CTATTTGTCA ATGACACTGT CAGTAATGAG AGTTACATTG AGAGTCTTTT AAGAAAAGAA 
CCAGAGATTA ATATAGAGGA GAAAGAACCA CAAATCTCAA TAGAACCGAC TCATAGGAAG 
GTAGAATCTG TGTCTTGTAT GCCCACCTTA GTAGCTCTGT CTGTAATAAG CTTGGGTTCC 
ATCACACTGG TCACAGGGAT GGGCATATAC ATCTGTTTAA GGAAAGGGGA AAAGCATCCC 
AGGGAAGATG AAAATTTGGA AGTACAGATT CCACTGAAAG GAAAAATTGA CTTGCATATG 
CGAGAGAGAA AGCCAATGGA TATTTCTAAT ATTTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

PubMed

Decreased expression of protocadherin 20 is associated with poor prognosis in hepatocellular carcinoma.
Oncotarget8(2)3018-3028(2017 Jan)
Wu Y,Zheng S,Yao J,Li M,Yang G,Zhang N,Zhang S,Zhong B

Genome-wide association analysis on normal hearing function identifies PCDH20 and SLC28A3 as candidates for hearing function and loss.
Human molecular genetics24(19)5655-64(2015 Oct)
Vuckovic D,Dawson S,Scheffer DI,Rantanen T,Morgan A,Di Stazio M,Vozzi D,Nutile T,Concas MP,Biino G,Nolan L,Bahl A,Loukola A,Viljanen A,Davis A,Ciullo M,Corey DP,Pirastu M,Gasparini P,Girotto G

Protocadherin20 Acts as a Tumor Suppressor Gene: Epigenetic Inactivation in Nasopharyngeal Carcinoma.
Journal of cellular biochemistry116(8)1766-75(2015 Aug)
Chen T,Long B,Ren G,Xiang T,Li L,Wang Z,He Y,Zeng Q,Hong S,Hu G

PCDH20 functions as a tumour-suppressor gene through antagonizing the Wnt/?-catenin signalling pathway in hepatocellular carcinoma.
Journal of viral hepatitis22(2)201-11(2015 Feb)
Lv J,Zhu P,Yang Z,Li M,Zhang X,Cheng J,Chen X,Lu F

Genome-wide association study of clinical dimensions of schizophrenia: polygenic effect on disorganized symptoms.
The American journal of psychiatry169(12)1309-17(2012 Dec)
Fanous AH,Zhou B,Aggen SH,Bergen SE,Amdur RL,Duan J,Sanders AR,Shi J,Mowry BJ,Olincy A,Amin F,Cloninger CR,Silverman JM,Buccola NG,Byerley WF,Black DW,Freedman R,Dudbridge F,Holmans PA,Ripke S,Gejman PV,Kendler KS,Levinson DF,

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PCDH20 cDNA ORF clone, Homo sapiens(human)

Gene

Clones

gRNAs

Related articles in PubMed

Target ORF information:

Target ORF information:

ORF Insert Sequence:

Target ORF information:

Target ORF information:

ORF Insert Sequence:

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