SRSF6 cDNA ORF clone, Homo sapiens(human)

Gene
Clones
gRNAs

Summary

Gene Symbol	SRSF6
Entrez Gene ID	6431
Full Name	serine and arginine rich splicing factor 6
Synonyms	B52,HEL-S-91,SFRS6,SRP55
General protein information	Preferred Names serine and arginine rich splicing factor 6 Names serine/arginine-rich splicing factor 6 SR splicing factor 6 epididymis secretory protein Li 91 pre-mRNA-splicing factor SRP55 splicing factor, arginine/serine-rich, 55 kDa
Gene Type	protein-coding
Organism	Homo sapiens(human)
Genome	Chromosome: 20 Map Location: 20q13.11
Summary	The protein encoded by this gene is involved in mRNA splicing and may play a role in the determination of alternative splicing. The encoded nuclear protein belongs to the splicing factor SR family and has been shown to bind with and modulate another member of the family, SFRS12. Alternative splicing results in multiple transcript variants. In addition, two pseudogenes, one on chromosome 17 and the other on the X chromosome, have been found for this gene.[provided by RefSeq, Sep 2010].
Disorder MIM:	601944

mRNA and Protein(s)

mRNA	Protein	Name
NM_006275.6	NP_006266.2	serine/arginine-rich splicing factor 6
NM_006275.5	NP_006266.2	serine/arginine-rich splicing factor 6

Pathways from BioSystems

Homologies

Canis lupus familiaris (dog)	SRSF6	XP_003639908.1
Bos taurus (cattle)	SRSF6	NP_001030349.1
Gallus gallus (chicken)	SRSF6	NP_001026014.1
Mus musculus (house mouse)	Srsf6	NP_080775.3
Homo sapiens (human)	SRSF6	NP_006266.2
Pan troglodytes (chimpanzee)	SRSF6	XP_003317036.1
Rattus norvegicus (Norway rat)	Srsf6	NP_001014207.2

Gene Ontology
Bibliography

Related articles in PubMed

SRp55 Regulates a Splicing Network that Controls Human Pancreatic Beta Cell Function and Survival.
Juan-Mateu J, Alvelos MI, Turatsinze JV, Villate O, Lizarraga-Mollinedo E, Grieco FA, Marroqu? L, Bugliani M, Marchetti P, Eizirik DL
Diabetes(2017 Dec)

SRSF6-regulated alternative splicing that promotes tumour progression offers a therapy target for colorectal cancer.
Wan L, Yu W, Shen E, Sun W, Liu Y, Kong J, Wu Y, Han F, Zhang L, Yu T, Zhou Y, Xie S, Xu E, Zhang H, Lai M
Gut(2017 Nov)

Faulty splicing and cytoskeleton abnormalities in Huntington's disease.
Fern?ndez-Nogales M, Santos-Galindo M, Hern?ndez IH, Cabrera JR, Lucas JJ
Brain pathology (Zurich, Switzerland)26(6)772-778(2016 Nov)

Long non-coding RNA LINC01133 inhibits epithelial-mesenchymal transition and metastasis in colorectal cancer by interacting with SRSF6.
Kong J, Sun W, Li C, Wan L, Wang S, Wu Y, Xu E, Zhang H, Lai M
Cancer letters380(2)476-84(2016 10)

GeneRIFs: Gene References Into Functions What's a GeneRIF?

The recent studies suggest that correcting the SRSF6-driven missplicing and/or microtubule-associated imbalance might be of therapeutic value in Huntington's disease.
Title: Faulty splicing and cytoskeleton abnormalities in Huntington's disease.

LINC01133 inhibits epithelial mesenchymal transformation and metastasis in colorectal neoplasms by directly binding to SRSF6 as a target mimic.
Title: Long non-coding RNA LINC01133 inhibits epithelial-mesenchymal transition and metastasis in colorectal cancer by interacting with SRSF6.

The authors propose that splicing at 3'ss A3 is dependent on binding of the enhancing SR proteins SRSF2 and SRSF6 to the HIV-1 tat ESE and ESE2 sequence.
Title: Balanced splicing at the Tat-specific HIV-1 3'ss A3 is critical for HIV-1 replication.

SRSF6 is a regulator of wound healing and tissue homeostasis in skin.
Title: Splicing factor SRSF6 promotes hyperplasia of sensitized skin.

Zinc inhibits the activity of SRSF6 and promotes elimination of exon 4, leading to preferential generation of BimS.
Title: Zinc-induced modulation of SRSF6 activity alters Bim splicing to promote generation of the most potent apoptotic isoform BimS.

The following SRSF6 gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the SRSF6 cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1⁺/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.

***CloneID	Accession No.	Definition	**Vector	*Turnaround time	Price (USD)
OHu19224	NM_006275.6 Latest version!	Homo sapiens serine and arginine rich splicing factor 6 (SRSF6), transcript variant 1, mRNA.	pcDNA3.1-C-(k)DYK or customized vector	in pcDNA3.1-C-(k)DYK	$189.50-$265.30 $379.00
View Old Accession Versions >>
OHu19224	NM_006275.5	Homo sapiens serine and arginine rich splicing factor 6 (SRSF6), transcript variant 1, mRNA.	pcDNA3.1-C-(k)DYK or customized vector	in pcDNA3.1-C-(k)DYK	$189.50-$265.30 $379.00
Hide Old Accession Versions >>

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** GenScript guarantees 100% sequence accuracy of all synthetic DNA constructs we deliver, but we do not guarantee protein expression in your experimental system. Protein expression is influenced by many factors that may vary between experiments or laboratories. In addition, please pay attention to the signal peptide, propeptide and transit peptide in target ORF, which may affect the choice of vector (N/C terminal tag vector).

***One clone ID might be correlated to multiple accession numbers, which share the same CDS sequence.

Reference Sequences (Refseq)

SRSF6 ( NM_006275.6 ) cDNA ORF clone, Homo sapiens(human) -> NP_006266.2 Homo sapiens serine and arginine rich splicing factor 6 (SRSF6), transcript variant 1, mRNA.

Price & Availability↑

CloneID	OHu19224
Clone ID Related Accession (Same CDS sequence)	NM_006275.6 , NM_006275.5
Accession Version	NM_006275.6 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 1035bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-10-13
Organism	Homo sapiens(human)
Product	serine/arginine-rich splicing factor 6
Comment	Comment: REVIEWED REFSEQ: This record has been curated by NCBI staff. The reference sequence was derived from DC306805.1, BC006832.2, AL031681.16 and BM830876.1. This sequence is a reference standard in the RefSeqGene project. On Nov 23, 2018 this sequence version replaced NM_006275.5. Transcript Variant: This variant (1) represents the shorter, protein-coding transcript. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: AK291203.1, SRR1660803.35187.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA1965299, SAMEA1966682 [ECO:0000348] ##Evidence-Data-END## ##RefSeq-Attributes-START## MANE Ensembl match :: ENST00000244020.5/ ENSP00000244020.3 RefSeq Select criteria :: based on single protein-coding transcript ##RefSeq-Attributes-END## COMPLETENESS: full length.

ATGCCGCGCG TCTACATAGG ACGCCTGAGC TACAACGTCC GGGAGAAGGA CATCCAGCGC 
TTTTTCAGTG GCTATGGCCG CCTCCTCGAA GTAGACCTCA AAAATGGGTA CGGCTTCGTG 
GAGTTCGAGG ACTCCCGCGA CGCCGACGAC GCCGTTTACG AGCTGAACGG CAAGGAGCTC 
TGCGGCGAGC GCGTGATCGT AGAGCACGCC CGGGGCCCGC GTCGCGATCG CGACGGCTAC 
AGCTACGGAA GCCGCAGTGG TGGAGGTGGA TACAGCAGTC GGAGAACATC TGGCAGAGAC 
AAATACGGAC CACCTGTTCG TACAGAATAC AGGCTTATTG TAGAAAATCT TTCTAGTCGG 
TGCAGTTGGC AAGATTTAAA GGATTTTATG CGACAAGCAG GTGAAGTAAC CTATGCGGAT 
GCCCACAAGG AACGAACAAA TGAGGGTGTA ATTGAGTTTC GCTCCTACTC TGACATGAAG 
CGTGCTTTGG ACAAACTGGA TGGCACAGAA ATAAATGGCA GAAATATTAG GCTTATTGAA 
GATAAGCCAC GCACAAGCCA TAGGCGATCT TACTCTGGAA GCAGATCCAG GTCTCGATCT 
AGAAGACGGT CACGAAGTAG GAGTCGCAGG AGCAGCCGCA GTAGATCTCG AAGTATCTCA 
AAAAGTCGCT CCCGTTCCAG GTCGCGGAGC AAAGGTCGAT CACGTTCTCG ATCAAAAGGC 
AGGAAATCTA GATCAAAGAG CAAATCTAAG CCCAAGTCTG ATCGGGGCTC CCATTCACAT 
TCTCGAAGCA GATCTAAGGA TGAGTATGAG AAATCTCGAA GCAGGTCTCG GTCCCGATCC 
CCTAAAGAAA ATGGAAAGGG TGATATAAAG TCAAAATCCA GATCAAGGAG CCAGTCCCGT 
TCCAATTCGC CGCTACCTGT TCCACCCTCA AAGGCCCGTT CTGTGTCCCC TCCACCAAAA 
AGAGCTACTT CAAGATCCCG TTCTAGATCT CGCTCAAAGT CAAGATCAAG GTCCAGGTCG 
AGTTCCAGAG ATTAA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_006266.2
CDS	139..1173
Translation	MPRVYIGRLSYNVREKDIQRFFSGYGRLLEVDLKNGYGFVEFEDSRDADDAVYELNGKELCGERVIVEHARGPRRDRDGYSYGSRSGGGGYSSRRTSGRDKYGPPVRTEYRLIVENLSSRCSWQDLKDFMRQAGEVTYADAHKERTNEGVIEFRSYSDMKRALDKLDGTEINGRNIRLIEDKPRTSHRRSYSGSRSRSRSRRRSRSRSRRSSRSRSRSISKSRSRSRSRSKGRSRSRSKGRKSRSKSKSKPKSDRGSHSHSRSRSKDEYEKSRSRSRSRSPKENGKGDIKSKSRSRSQSRSNSPLPVPPSKARSVSPPPKRATSRSRSRSRSKSRSRSRSSSRD

Target ORF information:

RefSeq Version	NM_006275.6
Organism	Homo sapiens(human)
Definition	Homo sapiens serine and arginine rich splicing factor 6 (SRSF6), transcript variant 1, mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_006275.6

ORF Insert Sequence:

ATGCCGCGCG TCTACATAGG ACGCCTGAGC TACAACGTCC GGGAGAAGGA CATCCAGCGC 
TTTTTCAGTG GCTATGGCCG CCTCCTCGAA GTAGACCTCA AAAATGGGTA CGGCTTCGTG 
GAGTTCGAGG ACTCCCGCGA CGCCGACGAC GCCGTTTACG AGCTGAACGG CAAGGAGCTC 
TGCGGCGAGC GCGTGATCGT AGAGCACGCC CGGGGCCCGC GTCGCGATCG CGACGGCTAC 
AGCTACGGAA GCCGCAGTGG TGGAGGTGGA TACAGCAGTC GGAGAACATC TGGCAGAGAC 
AAATACGGAC CACCTGTTCG TACAGAATAC AGGCTTATTG TAGAAAATCT TTCTAGTCGG 
TGCAGTTGGC AAGATTTAAA GGATTTTATG CGACAAGCAG GTGAAGTAAC CTATGCGGAT 
GCCCACAAGG AACGAACAAA TGAGGGTGTA ATTGAGTTTC GCTCCTACTC TGACATGAAG 
CGTGCTTTGG ACAAACTGGA TGGCACAGAA ATAAATGGCA GAAATATTAG GCTTATTGAA 
GATAAGCCAC GCACAAGCCA TAGGCGATCT TACTCTGGAA GCAGATCCAG GTCTCGATCT 
AGAAGACGGT CACGAAGTAG GAGTCGCAGG AGCAGCCGCA GTAGATCTCG AAGTATCTCA 
AAAAGTCGCT CCCGTTCCAG GTCGCGGAGC AAAGGTCGAT CACGTTCTCG ATCAAAAGGC 
AGGAAATCTA GATCAAAGAG CAAATCTAAG CCCAAGTCTG ATCGGGGCTC CCATTCACAT 
TCTCGAAGCA GATCTAAGGA TGAGTATGAG AAATCTCGAA GCAGGTCTCG GTCCCGATCC 
CCTAAAGAAA ATGGAAAGGG TGATATAAAG TCAAAATCCA GATCAAGGAG CCAGTCCCGT 
TCCAATTCGC CGCTACCTGT TCCACCCTCA AAGGCCCGTT CTGTGTCCCC TCCACCAAAA 
AGAGCTACTT CAAGATCCCG TTCTAGATCT CGCTCAAAGT CAAGATCAAG GTCCAGGTCG 
AGTTCCAGAG ATTAA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

SRSF6 ( NM_006275.5 ) cDNA ORF clone, Homo sapiens(human) -> NP_006266.2 Homo sapiens serine and arginine rich splicing factor 6 (SRSF6), transcript variant 1, mRNA.

Price & Availability↑

CloneID	OHu19224
Clone ID Related Accession (Same CDS sequence)	NM_006275.6 , NM_006275.5
Accession Version	NM_006275.5	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 1035bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2017-10-01
Organism	Homo sapiens(human)
Product	serine/arginine-rich splicing factor 6
Comment	Comment: REVIEWED REFSEQ: This record has been curated by NCBI staff. The reference sequence was derived from DC306805.1, BC006832.2, AL031681.16 and BM830876.1. This sequence is a reference standard in the RefSeqGene project. On Oct 11, 2008 this sequence version replaced NM_006275.4. Transcript Variant: This variant (1) represents the shorter, protein-coding transcript. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: SRR1660803.35187.1, SRR1660805.223322.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA1965299, SAMEA1966682 [ECO:0000348] ##Evidence-Data-END## COMPLETENESS: complete on the 3' end.

ATGCCGCGCG TCTACATAGG ACGCCTGAGC TACAACGTCC GGGAGAAGGA CATCCAGCGC 
TTTTTCAGTG GCTATGGCCG CCTCCTCGAA GTAGACCTCA AAAATGGGTA CGGCTTCGTG 
GAGTTCGAGG ACTCCCGCGA CGCCGACGAC GCCGTTTACG AGCTGAACGG CAAGGAGCTC 
TGCGGCGAGC GCGTGATCGT AGAGCACGCC CGGGGCCCGC GTCGCGATCG CGACGGCTAC 
AGCTACGGAA GCCGCAGTGG TGGAGGTGGA TACAGCAGTC GGAGAACATC TGGCAGAGAC 
AAATACGGAC CACCTGTTCG TACAGAATAC AGGCTTATTG TAGAAAATCT TTCTAGTCGG 
TGCAGTTGGC AAGATTTAAA GGATTTTATG CGACAAGCAG GTGAAGTAAC CTATGCGGAT 
GCCCACAAGG AACGAACAAA TGAGGGTGTA ATTGAGTTTC GCTCCTACTC TGACATGAAG 
CGTGCTTTGG ACAAACTGGA TGGCACAGAA ATAAATGGCA GAAATATTAG GCTTATTGAA 
GATAAGCCAC GCACAAGCCA TAGGCGATCT TACTCTGGAA GCAGATCCAG GTCTCGATCT 
AGAAGACGGT CACGAAGTAG GAGTCGCAGG AGCAGCCGCA GTAGATCTCG AAGTATCTCA 
AAAAGTCGCT CCCGTTCCAG GTCGCGGAGC AAAGGTCGAT CACGTTCTCG ATCAAAAGGC 
AGGAAATCTA GATCAAAGAG CAAATCTAAG CCCAAGTCTG ATCGGGGCTC CCATTCACAT 
TCTCGAAGCA GATCTAAGGA TGAGTATGAG AAATCTCGAA GCAGGTCTCG GTCCCGATCC 
CCTAAAGAAA ATGGAAAGGG TGATATAAAG TCAAAATCCA GATCAAGGAG CCAGTCCCGT 
TCCAATTCGC CGCTACCTGT TCCACCCTCA AAGGCCCGTT CTGTGTCCCC TCCACCAAAA 
AGAGCTACTT CAAGATCCCG TTCTAGATCT CGCTCAAAGT CAAGATCAAG GTCCAGGTCG 
AGTTCCAGAG ATTAA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_006266.2
CDS	171..1205
Translation	MPRVYIGRLSYNVREKDIQRFFSGYGRLLEVDLKNGYGFVEFEDSRDADDAVYELNGKELCGERVIVEHARGPRRDRDGYSYGSRSGGGGYSSRRTSGRDKYGPPVRTEYRLIVENLSSRCSWQDLKDFMRQAGEVTYADAHKERTNEGVIEFRSYSDMKRALDKLDGTEINGRNIRLIEDKPRTSHRRSYSGSRSRSRSRRRSRSRSRRSSRSRSRSISKSRSRSRSRSKGRSRSRSKGRKSRSKSKSKPKSDRGSHSHSRSRSKDEYEKSRSRSRSRSPKENGKGDIKSKSRSRSQSRSNSPLPVPPSKARSVSPPPKRATSRSRSRSRSKSRSRSRSSSRD

Target ORF information:

RefSeq Version	NM_006275.5
Organism	Homo sapiens(human)
Definition	Homo sapiens serine and arginine rich splicing factor 6 (SRSF6), transcript variant 1, mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_006275.5

ORF Insert Sequence:

ATGCCGCGCG TCTACATAGG ACGCCTGAGC TACAACGTCC GGGAGAAGGA CATCCAGCGC 
TTTTTCAGTG GCTATGGCCG CCTCCTCGAA GTAGACCTCA AAAATGGGTA CGGCTTCGTG 
GAGTTCGAGG ACTCCCGCGA CGCCGACGAC GCCGTTTACG AGCTGAACGG CAAGGAGCTC 
TGCGGCGAGC GCGTGATCGT AGAGCACGCC CGGGGCCCGC GTCGCGATCG CGACGGCTAC 
AGCTACGGAA GCCGCAGTGG TGGAGGTGGA TACAGCAGTC GGAGAACATC TGGCAGAGAC 
AAATACGGAC CACCTGTTCG TACAGAATAC AGGCTTATTG TAGAAAATCT TTCTAGTCGG 
TGCAGTTGGC AAGATTTAAA GGATTTTATG CGACAAGCAG GTGAAGTAAC CTATGCGGAT 
GCCCACAAGG AACGAACAAA TGAGGGTGTA ATTGAGTTTC GCTCCTACTC TGACATGAAG 
CGTGCTTTGG ACAAACTGGA TGGCACAGAA ATAAATGGCA GAAATATTAG GCTTATTGAA 
GATAAGCCAC GCACAAGCCA TAGGCGATCT TACTCTGGAA GCAGATCCAG GTCTCGATCT 
AGAAGACGGT CACGAAGTAG GAGTCGCAGG AGCAGCCGCA GTAGATCTCG AAGTATCTCA 
AAAAGTCGCT CCCGTTCCAG GTCGCGGAGC AAAGGTCGAT CACGTTCTCG ATCAAAAGGC 
AGGAAATCTA GATCAAAGAG CAAATCTAAG CCCAAGTCTG ATCGGGGCTC CCATTCACAT 
TCTCGAAGCA GATCTAAGGA TGAGTATGAG AAATCTCGAA GCAGGTCTCG GTCCCGATCC 
CCTAAAGAAA ATGGAAAGGG TGATATAAAG TCAAAATCCA GATCAAGGAG CCAGTCCCGT 
TCCAATTCGC CGCTACCTGT TCCACCCTCA AAGGCCCGTT CTGTGTCCCC TCCACCAAAA 
AGAGCTACTT CAAGATCCCG TTCTAGATCT CGCTCAAAGT CAAGATCAAG GTCCAGGTCG 
AGTTCCAGAG ATTAA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

PubMed

SRp55 Regulates a Splicing Network that Controls Human Pancreatic Beta Cell Function and Survival.
Diabetes(2017 Dec)
Juan-Mateu J,Alvelos MI,Turatsinze JV,Villate O,Lizarraga-Mollinedo E,Grieco FA,Marroqu? L,Bugliani M,Marchetti P,Eizirik DL

SRSF6-regulated alternative splicing that promotes tumour progression offers a therapy target for colorectal cancer.
Gut(2017 Nov)
Wan L,Yu W,Shen E,Sun W,Liu Y,Kong J,Wu Y,Han F,Zhang L,Yu T,Zhou Y,Xie S,Xu E,Zhang H,Lai M

Faulty splicing and cytoskeleton abnormalities in Huntington's disease.
Brain pathology (Zurich, Switzerland)26(6)772-778(2016 Nov)
Fern?ndez-Nogales M,Santos-Galindo M,Hern?ndez IH,Cabrera JR,Lucas JJ

Long non-coding RNA LINC01133 inhibits epithelial-mesenchymal transition and metastasis in colorectal cancer by interacting with SRSF6.
Cancer letters380(2)476-84(2016 10)
Kong J,Sun W,Li C,Wan L,Wang S,Wu Y,Xu E,Zhang H,Lai M

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SRSF6 cDNA ORF clone, Homo sapiens(human)

Gene

Clones

gRNAs

Related articles in PubMed

Target ORF information:

Target ORF information:

ORF Insert Sequence:

Target ORF information:

Target ORF information:

ORF Insert Sequence:

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