XYLT2 cDNA ORF clone, Homo sapiens(human)

Gene
Clones
gRNAs

Summary

Gene Symbol	XYLT2
Entrez Gene ID	64132
Full Name	xylosyltransferase 2
Synonyms	PXYLT2,SOS,XT-II,XT2,xylT-II
General protein information	Preferred Names xylosyltransferase 2 Names xylosyltransferase 2 UDP-D-xylose:proteoglycan core protein beta-D-xylosyltransferase peptide O-xylosyltransferase 1 protein xylosyltransferase 2 xylosyltransferase II
Gene Type	protein-coding
Organism	Homo sapiens(human)
Genome	Chromosome: 17 Map Location: 17q21.33
Summary	The protein encoded by this gene is an isoform of xylosyltransferase, which belongs to a family of glycosyltransferases. This enzyme transfers xylose from UDP-xylose to specific serine residues of the core protein and initiates the biosynthesis of glycosaminoglycan chains in proteoglycans including chondroitin sulfate, heparan sulfate, heparin and dermatan sulfate. The enzyme activity, which is increased in scleroderma patients, is a diagnostic marker for the determination of sclerotic activity in systemic sclerosis. Alternatively spliced transcript variants have been found for this gene. [provided by RefSeq, Dec 2013].
Disorder MIM:	608125
Disorder Html:	{Pseudoxanthoma elasticum, modifier of severity of}, 264800 (3); Spondyloocular syndrome, 605822 (3)

mRNA and Protein(s)

mRNA	Protein	Name
NM_022167.3	NP_071450.2	xylosyltransferase 2
XM_005257572.4	XP_005257629.1	xylosyltransferase 2 isoform X1
NM_022167.4	NP_071450.2	xylosyltransferase 2

Pathways from BioSystems

Homologies

Mus musculus (house mouse)	Xylt2	NP_665827.2
Pan troglodytes (chimpanzee)	XYLT2	NP_001009086.1
Bos taurus (cattle)	XYLT2	NP_001008667.1
Xenopus tropicalis (tropical clawed frog)	xylt2	NP_001006733.1
Rattus norvegicus (Norway rat)	Xylt2	NP_071632.2
Gallus gallus (chicken)	XYLT2	NP_001001785.1
	XYLT2	XP_001093519.1
Homo sapiens (human)	XYLT2	NP_071450.2
Canis lupus familiaris (dog)	XYLT2	NP_001008714.1
Danio rerio (zebrafish)	zgc:194562	NP_001124250.1

Gene Ontology
Bibliography

Related articles in PubMed

Homozygous XYLT2 variants as a cause of spondyloocular syndrome.
Umair M, Eckstein G, Rudolph G, Strom T, Graf E, Hendig D, Hoover J, Alanay J, Meitinger T, Schmidt H, Ahmad W
Clinical genetics(2017 Nov)

Abnormal Proteoglycan Synthesis Due to Gene Defects Causes Skeletal Diseases with Overlapping Phenotypes.
Taylan F, M?kitie O
Hormone and metabolic research = Hormon- und Stoffwechselforschung = Hormones et metabolisme48(11)745-754(2016 Nov)

Spondyloocular Syndrome: Novel Mutations in XYLT2 Gene and Expansion of the Phenotypic Spectrum.
Taylan F, Costantini A, Coles N, Pekkinen M, H?on E, ??klar Z, Berbero?lu M, K?mpe A, K?yk?m E, Grigelioniene G, T?ys?z B, M?kitie O
Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research31(8)1577-85(2016 Aug)

Homozygosity for frameshift mutations in XYLT2 result in a spondylo-ocular syndrome with bone fragility, cataracts, and hearing defects.
Munns CF, Fahiminiya S, Poudel N, Munteanu MC, Majewski J, Sillence DO, Metcalf JP, Biggin A, Glorieux F, Fassier F, Rauch F, Hinsdale ME
American journal of human genetics96(6)971-8(2015 Jun)

Xylosyltransferase II is the predominant isoenzyme which is responsible for the steady-state level of xylosyltransferase activity in human serum.
Kuhn J, G?tting C, Beahm BJ, Bertozzi CR, Faust I, Kuzaj P, Knabbe C, Hendig D
Biochemical and biophysical research communications459(3)469-74(2015 Apr)

GeneRIFs: Gene References Into Functions What's a GeneRIF?

XYLT2 mutations cause a relatively distinct phenotype, the so-called spondyloocular syndrome.
Title: Abnormal Proteoglycan Synthesis Due to Gene Defects Causes Skeletal Diseases with Overlapping Phenotypes.

mutations in the XYLT2 gene result in a variable phenotype dominated by spinal osteoporosis, cataract, and hearing loss.
Title: Spondyloocular Syndrome: Novel Mutations in XYLT2 Gene and Expansion of the Phenotypic Spectrum.

Homozygosity for frameshift mutations in XYLT2 result in a spondylo-ocular syndrome with bone fragility, cataracts, and hearing defects.
Title: Homozygosity for frameshift mutations in XYLT2 result in a spondylo-ocular syndrome with bone fragility, cataracts, and hearing defects.

Demonstrate that XT-II is the predominant isoenzyme responsible for XT activity in serum. The proof was performed using UDP-xylose as the xylose donor, as well as the compound UDP-4-azido-4-deoxyxylose, which is a selective xylose donor for XT-I.
Title: Xylosyltransferase II is the predominant isoenzyme which is responsible for the steady-state level of xylosyltransferase activity in human serum.

Seven XYLT2 promoter single nucleotide variants (SNVs) were identified and genotyped.
Title: Identification and characterization of human xylosyltransferase II promoter single nucleotide variants.

The following XYLT2 gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the XYLT2 cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1⁺/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.

***CloneID	Accession No.	Definition	**Vector	*Turnaround time	Price (USD)
OHu21170	NM_022167.4 Latest version!	Homo sapiens xylosyltransferase 2 (XYLT2), transcript variant 1, mRNA.	pcDNA3.1-C-(k)DYK or customized vector	12-14	$265.30 $379.00
OHu50579	XM_005257572.4 Latest version!	Homo sapiens xylosyltransferase 2 (XYLT2), transcript variant X1, mRNA.	pcDNA3.1-C-(k)DYK or customized vector	12-14	$475.30 $679.00
View Old Accession Versions >>
OHu21170	NM_022167.3	Homo sapiens xylosyltransferase 2 (XYLT2), transcript variant 1, mRNA.	pcDNA3.1-C-(k)DYK or customized vector	12-14	$265.30 $379.00
Hide Old Accession Versions >>

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** GenScript guarantees 100% sequence accuracy of all synthetic DNA constructs we deliver, but we do not guarantee protein expression in your experimental system. Protein expression is influenced by many factors that may vary between experiments or laboratories. In addition, please pay attention to the signal peptide, propeptide and transit peptide in target ORF, which may affect the choice of vector (N/C terminal tag vector).

***One clone ID might be correlated to multiple accession numbers, which share the same CDS sequence.

Reference Sequences (Refseq)

XYLT2 ( NM_022167.3 ) cDNA ORF clone, Homo sapiens(human) -> NP_071450.2 Homo sapiens xylosyltransferase 2 (XYLT2), transcript variant 1, mRNA.

Price & Availability↑

CloneID	OHu21170
Clone ID Related Accession (Same CDS sequence)	NM_022167.3 , NM_022167.4
Accession Version	NM_022167.3	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 2598bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-02-23
Organism	Homo sapiens(human)
Product	xylosyltransferase 2
Comment	Comment: REVIEWED REFSEQ: This record has been curated by NCBI staff. The reference sequence was derived from AJ277442.1, AK299999.1, BQ018370.1 and BM726479.1. This sequence is a reference standard in the RefSeqGene project. On Jan 1, 2014 this sequence version replaced NM_022167.2. Transcript Variant: This variant (1) represents the protein-coding transcript. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: AJ277442.1, SRR1803611.7410.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA1965299, SAMEA1966682 [ECO:0000348] ##Evidence-Data-END## COMPLETENESS: complete on the 3' end.

ATGGTGGCGA GCGCGCGAGT GCAGAAGCTG GTGCGGCGCT ACAAGCTGGC GATTGCCACG 
GCGCTGGCCA TCCTGCTGCT GCAGGGCCTG GTAGTGTGGA GCTTCAGCGG CCTGGAGGAG 
GACGAGGCGG GCGAGAAAGG AAGGCAGAGG AAGCCACGGC CACTGGACCC TGGCGAGGGT 
TCCAAGGACA CAGACAGTTC AGCAGGGCGA CGGGGCAGCA CAGGCAGAAG GCATGGGCGC 
TGGCGGGGCC GTGCTGAGAG CCCAGGAGTG CCCGTGGCCA AGGTGGTACG GGCAGTAACC 
AGCCGGCAGA GAGCCAGCCG GCGGGTCCCA CCTGCCCCAC CCCCGGAAGC CCCAGGCCGC 
CAGAACCTGA GTGGGGCAGC AGCTGGGGAG GCGCTGGTAG GGGCAGCTGG CTTCCCACCA 
CACGGAGATA CAGGGAGCGT GGAGGGCGCC CCCCAGCCCA CGGACAATGG CTTCACCCCC 
AAGTGCGAGA TCGTGGGCAA GGACGCACTG TCTGCACTGG CCCGGGCCAG CACCAAGCAG 
TGCCAGCAGG AGATCGCCAA TGTGGTGTGC CTGCACCAGG CTGGGAGCCT CATGCCCAAG 
GCTGTGCCCC GGCACTGTCA GCTGACTGGG AAGATGAGCC CCGGCATCCA GTGGGATGAG 
AGCCAAGCCC AGCAGCCCAT GGATGGCCCC CCGGTGCGAA TCGCCTACAT GCTGGTGGTT 
CACGGCCGCG CCATCCGCCA GCTGAAGCGT CTCCTCAAGG CCGTTTATCA CGAGCAGCAC 
TTCTTTTACA TCCATGTGGA CAAGCGTTCC GACTACCTGC ACCGGGAGGT GGTGGAGCTG 
GCCCAGGGCT ATGATAACGT GCGGGTGACG CCCTGGCGCA TGGTTACCAT CTGGGGCGGG 
GCCAGCCTCC TGAGGATGTA CCTGCGGAGC ATGCGGGACC TGCTAGAGGT GCCTGGCTGG 
GCCTGGGACT TCTTCATCAA CCTCAGTGCC ACTGACTATC CAACCAGGAC CAATGAGGAG 
CTGGTGGCAT TCCTATCCAA GAACCGGGAC AAGAATTTCC TCAAGTCACA TGGCCGGGAC 
AACTCCAGGT TCATCAAGAA ACAGGGCCTG GACCGGCTCT TCCATGAGTG CGACTCACAC 
ATGTGGCGCC TGGGCGAGCG GCAGATCCCA GCAGGCATTG TGGTGGATGG CGGTTCTGAC 
TGGTTCGTGC TGACACGCAG CTTTGTGGAG TATGTGGTGT ACACAGATGA CCCGCTTGTG 
GCCCAGCTGC GCCAGTTCTA CACATACACA CTGCTCCCAG CCGAGTCCTT CTTCCACACG 
GTGCTGGAGA ACAGCCTGGC CTGTGAGACC CTCGTGGACA ACAACCTGCG GGTCACCAAC 
TGGAACCGCA AGCTGGGCTG CAAGTGCCAG TACAAGCACA TTGTGGACTG GTGTGGCTGC 
TCCCCCAACG ACTTCAAGCC ACAGGACTTC CTCCGGCTGC AGCAAGTCTC CAGACCCACC 
TTCTTCGCCC GGAAGTTCGA GTCGACTGTG AACCAGGAGG TGCTGGAAAT CCTGGACTTC 
CACCTGTATG GCAGCTACCC CCCCGGCACG CCAGCCCTCA AGGCCTACTG GGAGAACACC 
TACGACGCGG CTGATGGCCC CAGTGGGCTC AGTGATGTCA TGCTCACTGC TTACACAGCC 
TTCGCCCGCC TCAGCCTGCA CCATGCCGCC ACTGCTGCAC CCCCAATGGG CACCCCACTC 
TGCAGGTTTG AGCCCAGGGG CTTGCCGTCC AGCGTGCACC TGTATTTCTA TGACGACCAT 
TTCCAGGGCT ACCTGGTGAC GCAGGCGGTG CAGCCCTCAG CCCAGGGGCC GGCAGAGACG 
CTTGAGATGT GGCTGATGCC CCAAGGGTCG CTGAAGCTGT TGGGGCGCAG TGACCAGGCC 
AGCCGGCTCC AGAGTCTGGA GGTTGGCACT GATTGGGACC CCAAAGAGCG TCTTTTCCGG 
AACTTTGGGG GGTTACTGGG GCCGCTGGAC GAGCCTGTGG CCGTGCAGCG CTGGGCCCGG 
GGCCCCAACC TCACAGCCAC AGTGGTCTGG ATCGACCCAA CCTATGTGGT GGCCACATCT 
TATGACATCA CAGTAGATAC GGAGACTGAG GTCACGCAAT ACAAGCCCCC ACTGAGCCGG 
CCCCTGCGGC CAGGGCCCTG GACTGTTCGA CTCCTTCAGT TCTGGGAACC GCTGGGTGAG 
ACCCGCTTCC TTGTGCTGCC CTTGACCTTC AACCGCAAAC TACCTCTCAG GAAAGATGAT 
GCCAGCTGGC TGCACGCAGG GCCACCCCAC AACGAGTACA TGGAGCAGAG TTTCCAGGGC 
CTGAGTAGCA TCCTGAACCT GCCTCAGCCG GAGCTCGCGG AGGAGGCTGC CCAGCGGCAC 
ACACAGCTCA CAGGCCCTGC GCTCGAGGCC TGGACAGACA GGGAACTGAG CAGCTTCTGG 
TCCGTGGCTG GACTGTGTGC CATAGGCCCC TCTCCCTGCC CCTCCCTGGA GCCCTGCAGA 
CTGACCAGCT GGAGCTCTCT GTCCCCCGAC CCCAAATCAG AGCTGGGGCC TGTCAAAGCA 
GACGGGCGAC TCAGGTAG

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_071450.2
CDS	110..2707
Translation	MVASARVQKLVRRYKLAIATALAILLLQGLVVWSFSGLEEDEAGEKGRQRKPRPLDPGEGSKDTDSSAGRRGSTGRRHGRWRGRAESPGVPVAKVVRAVTSRQRASRRVPPAPPPEAPGRQNLSGAAAGEALVGAAGFPPHGDTGSVEGAPQPTDNGFTPKCEIVGKDALSALARASTKQCQQEIANVVCLHQAGSLMPKAVPRHCQLTGKMSPGIQWDESQAQQPMDGPPVRIAYMLVVHGRAIRQLKRLLKAVYHEQHFFYIHVDKRSDYLHREVVELAQGYDNVRVTPWRMVTIWGGASLLRMYLRSMRDLLEVPGWAWDFFINLSATDYPTRTNEELVAFLSKNRDKNFLKSHGRDNSRFIKKQGLDRLFHECDSHMWRLGERQIPAGIVVDGGSDWFVLTRSFVEYVVYTDDPLVAQLRQFYTYTLLPAESFFHTVLENSLACETLVDNNLRVTNWNRKLGCKCQYKHIVDWCGCSPNDFKPQDFLRLQQVSRPTFFARKFESTVNQEVLEILDFHLYGSYPPGTPALKAYWENTYDAADGPSGLSDVMLTAYTAFARLSLHHAATAAPPMGTPLCRFEPRGLPSSVHLYFYDDHFQGYLVTQAVQPSAQGPAETLEMWLMPQGSLKLLGRSDQASRLQSLEVGTDWDPKERLFRNFGGLLGPLDEPVAVQRWARGPNLTATVVWIDPTYVVATSYDITVDTETEVTQYKPPLSRPLRPGPWTVRLLQFWEPLGETRFLVLPLTFNRKLPLRKDDASWLHAGPPHNEYMEQSFQGLSSILNLPQPELAEEAAQRHTQLTGPALEAWTDRELSSFWSVAGLCAIGPSPCPSLEPCRLTSWSSLSPDPKSELGPVKADGRLR

Target ORF information:

RefSeq Version	NM_022167.3
Organism	Homo sapiens(human)
Definition	Homo sapiens xylosyltransferase 2 (XYLT2), transcript variant 1, mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_022167.3

ORF Insert Sequence:

ATGGTGGCGA GCGCGCGAGT GCAGAAGCTG GTGCGGCGCT ACAAGCTGGC GATTGCCACG 
GCGCTGGCCA TCCTGCTGCT GCAGGGCCTG GTAGTGTGGA GCTTCAGCGG CCTGGAGGAG 
GACGAGGCGG GCGAGAAAGG AAGGCAGAGG AAGCCACGGC CACTGGACCC TGGCGAGGGT 
TCCAAGGACA CAGACAGTTC AGCAGGGCGA CGGGGCAGCA CAGGCAGAAG GCATGGGCGC 
TGGCGGGGCC GTGCTGAGAG CCCAGGAGTG CCCGTGGCCA AGGTGGTACG GGCAGTAACC 
AGCCGGCAGA GAGCCAGCCG GCGGGTCCCA CCTGCCCCAC CCCCGGAAGC CCCAGGCCGC 
CAGAACCTGA GTGGGGCAGC AGCTGGGGAG GCGCTGGTAG GGGCAGCTGG CTTCCCACCA 
CACGGAGATA CAGGGAGCGT GGAGGGCGCC CCCCAGCCCA CGGACAATGG CTTCACCCCC 
AAGTGCGAGA TCGTGGGCAA GGACGCACTG TCTGCACTGG CCCGGGCCAG CACCAAGCAG 
TGCCAGCAGG AGATCGCCAA TGTGGTGTGC CTGCACCAGG CTGGGAGCCT CATGCCCAAG 
GCTGTGCCCC GGCACTGTCA GCTGACTGGG AAGATGAGCC CCGGCATCCA GTGGGATGAG 
AGCCAAGCCC AGCAGCCCAT GGATGGCCCC CCGGTGCGAA TCGCCTACAT GCTGGTGGTT 
CACGGCCGCG CCATCCGCCA GCTGAAGCGT CTCCTCAAGG CCGTTTATCA CGAGCAGCAC 
TTCTTTTACA TCCATGTGGA CAAGCGTTCC GACTACCTGC ACCGGGAGGT GGTGGAGCTG 
GCCCAGGGCT ATGATAACGT GCGGGTGACG CCCTGGCGCA TGGTTACCAT CTGGGGCGGG 
GCCAGCCTCC TGAGGATGTA CCTGCGGAGC ATGCGGGACC TGCTAGAGGT GCCTGGCTGG 
GCCTGGGACT TCTTCATCAA CCTCAGTGCC ACTGACTATC CAACCAGGAC CAATGAGGAG 
CTGGTGGCAT TCCTATCCAA GAACCGGGAC AAGAATTTCC TCAAGTCACA TGGCCGGGAC 
AACTCCAGGT TCATCAAGAA ACAGGGCCTG GACCGGCTCT TCCATGAGTG CGACTCACAC 
ATGTGGCGCC TGGGCGAGCG GCAGATCCCA GCAGGCATTG TGGTGGATGG CGGTTCTGAC 
TGGTTCGTGC TGACACGCAG CTTTGTGGAG TATGTGGTGT ACACAGATGA CCCGCTTGTG 
GCCCAGCTGC GCCAGTTCTA CACATACACA CTGCTCCCAG CCGAGTCCTT CTTCCACACG 
GTGCTGGAGA ACAGCCTGGC CTGTGAGACC CTCGTGGACA ACAACCTGCG GGTCACCAAC 
TGGAACCGCA AGCTGGGCTG CAAGTGCCAG TACAAGCACA TTGTGGACTG GTGTGGCTGC 
TCCCCCAACG ACTTCAAGCC ACAGGACTTC CTCCGGCTGC AGCAAGTCTC CAGACCCACC 
TTCTTCGCCC GGAAGTTCGA GTCGACTGTG AACCAGGAGG TGCTGGAAAT CCTGGACTTC 
CACCTGTATG GCAGCTACCC CCCCGGCACG CCAGCCCTCA AGGCCTACTG GGAGAACACC 
TACGACGCGG CTGATGGCCC CAGTGGGCTC AGTGATGTCA TGCTCACTGC TTACACAGCC 
TTCGCCCGCC TCAGCCTGCA CCATGCCGCC ACTGCTGCAC CCCCAATGGG CACCCCACTC 
TGCAGGTTTG AGCCCAGGGG CTTGCCGTCC AGCGTGCACC TGTATTTCTA TGACGACCAT 
TTCCAGGGCT ACCTGGTGAC GCAGGCGGTG CAGCCCTCAG CCCAGGGGCC GGCAGAGACG 
CTTGAGATGT GGCTGATGCC CCAAGGGTCG CTGAAGCTGT TGGGGCGCAG TGACCAGGCC 
AGCCGGCTCC AGAGTCTGGA GGTTGGCACT GATTGGGACC CCAAAGAGCG TCTTTTCCGG 
AACTTTGGGG GGTTACTGGG GCCGCTGGAC GAGCCTGTGG CCGTGCAGCG CTGGGCCCGG 
GGCCCCAACC TCACAGCCAC AGTGGTCTGG ATCGACCCAA CCTATGTGGT GGCCACATCT 
TATGACATCA CAGTAGATAC GGAGACTGAG GTCACGCAAT ACAAGCCCCC ACTGAGCCGG 
CCCCTGCGGC CAGGGCCCTG GACTGTTCGA CTCCTTCAGT TCTGGGAACC GCTGGGTGAG 
ACCCGCTTCC TTGTGCTGCC CTTGACCTTC AACCGCAAAC TACCTCTCAG GAAAGATGAT 
GCCAGCTGGC TGCACGCAGG GCCACCCCAC AACGAGTACA TGGAGCAGAG TTTCCAGGGC 
CTGAGTAGCA TCCTGAACCT GCCTCAGCCG GAGCTCGCGG AGGAGGCTGC CCAGCGGCAC 
ACACAGCTCA CAGGCCCTGC GCTCGAGGCC TGGACAGACA GGGAACTGAG CAGCTTCTGG 
TCCGTGGCTG GACTGTGTGC CATAGGCCCC TCTCCCTGCC CCTCCCTGGA GCCCTGCAGA 
CTGACCAGCT GGAGCTCTCT GTCCCCCGAC CCCAAATCAG AGCTGGGGCC TGTCAAAGCA 
GACGGGCGAC TCAGGTAG

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

XYLT2 ( NM_022167.4 ) cDNA ORF clone, Homo sapiens(human) -> NP_071450.2 Homo sapiens xylosyltransferase 2 (XYLT2), transcript variant 1, mRNA.

Price & Availability↑

CloneID	OHu21170
Clone ID Related Accession (Same CDS sequence)	NM_022167.3 , NM_022167.4
Accession Version	NM_022167.4 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 2598bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-10-07
Organism	Homo sapiens(human)
Product	xylosyltransferase 2
Comment	Comment: REVIEWED REFSEQ: This record has been curated by NCBI staff. The reference sequence was derived from AJ277442.1, AK299999.1, BQ018370.1 and BM726479.1. This sequence is a reference standard in the RefSeqGene project. On May 17, 2019 this sequence version replaced NM_022167.3. Transcript Variant: This variant (1) represents the protein-coding transcript. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: SRR1803613.234339.1, SRR1803616.133397.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA1965299, SAMEA1966682 [ECO:0000348] ##Evidence-Data-END## ##RefSeq-Attributes-START## MANE Ensembl match :: ENST00000017003.7/ ENSP00000017003.2 RefSeq Select criteria :: based on conservation, expression, longest protein ##RefSeq-Attributes-END## COMPLETENESS: complete on the 3' end.

ATGGTGGCGA GCGCGCGAGT GCAGAAGCTG GTGCGGCGCT ACAAGCTGGC GATTGCCACG 
GCGCTGGCCA TCCTGCTGCT GCAGGGCCTG GTAGTGTGGA GCTTCAGCGG CCTGGAGGAG 
GACGAGGCGG GCGAGAAAGG AAGGCAGAGG AAGCCACGGC CACTGGACCC TGGCGAGGGT 
TCCAAGGACA CAGACAGTTC AGCAGGGCGA CGGGGCAGCA CAGGCAGAAG GCATGGGCGC 
TGGCGGGGCC GTGCTGAGAG CCCAGGAGTG CCCGTGGCCA AGGTGGTACG GGCAGTAACC 
AGCCGGCAGA GAGCCAGCCG GCGGGTCCCA CCTGCCCCAC CCCCGGAAGC CCCAGGCCGC 
CAGAACCTGA GTGGGGCAGC AGCTGGGGAG GCGCTGGTAG GGGCAGCTGG CTTCCCACCA 
CACGGAGATA CAGGGAGCGT GGAGGGCGCC CCCCAGCCCA CGGACAATGG CTTCACCCCC 
AAGTGCGAGA TCGTGGGCAA GGACGCACTG TCTGCACTGG CCCGGGCCAG CACCAAGCAG 
TGCCAGCAGG AGATCGCCAA TGTGGTGTGC CTGCACCAGG CTGGGAGCCT CATGCCCAAG 
GCTGTGCCCC GGCACTGTCA GCTGACTGGG AAGATGAGCC CCGGCATCCA GTGGGATGAG 
AGCCAAGCCC AGCAGCCCAT GGATGGCCCC CCGGTGCGAA TCGCCTACAT GCTGGTGGTT 
CACGGCCGCG CCATCCGCCA GCTGAAGCGT CTCCTCAAGG CCGTTTATCA CGAGCAGCAC 
TTCTTTTACA TCCATGTGGA CAAGCGTTCC GACTACCTGC ACCGGGAGGT GGTGGAGCTG 
GCCCAGGGCT ATGATAACGT GCGGGTGACG CCCTGGCGCA TGGTTACCAT CTGGGGCGGG 
GCCAGCCTCC TGAGGATGTA CCTGCGGAGC ATGCGGGACC TGCTAGAGGT GCCTGGCTGG 
GCCTGGGACT TCTTCATCAA CCTCAGTGCC ACTGACTATC CAACCAGGAC CAATGAGGAG 
CTGGTGGCAT TCCTATCCAA GAACCGGGAC AAGAATTTCC TCAAGTCACA TGGCCGGGAC 
AACTCCAGGT TCATCAAGAA ACAGGGCCTG GACCGGCTCT TCCATGAGTG CGACTCACAC 
ATGTGGCGCC TGGGCGAGCG GCAGATCCCA GCAGGCATTG TGGTGGATGG CGGTTCTGAC 
TGGTTCGTGC TGACACGCAG CTTTGTGGAG TATGTGGTGT ACACAGATGA CCCGCTTGTG 
GCCCAGCTGC GCCAGTTCTA CACATACACA CTGCTCCCAG CCGAGTCCTT CTTCCACACG 
GTGCTGGAGA ACAGCCTGGC CTGTGAGACC CTCGTGGACA ACAACCTGCG GGTCACCAAC 
TGGAACCGCA AGCTGGGCTG CAAGTGCCAG TACAAGCACA TTGTGGACTG GTGTGGCTGC 
TCCCCCAACG ACTTCAAGCC ACAGGACTTC CTCCGGCTGC AGCAAGTCTC CAGACCCACC 
TTCTTCGCCC GGAAGTTCGA GTCGACTGTG AACCAGGAGG TGCTGGAAAT CCTGGACTTC 
CACCTGTATG GCAGCTACCC CCCCGGCACG CCAGCCCTCA AGGCCTACTG GGAGAACACC 
TACGACGCGG CTGATGGCCC CAGTGGGCTC AGTGATGTCA TGCTCACTGC TTACACAGCC 
TTCGCCCGCC TCAGCCTGCA CCATGCCGCC ACTGCTGCAC CCCCAATGGG CACCCCACTC 
TGCAGGTTTG AGCCCAGGGG CTTGCCGTCC AGCGTGCACC TGTATTTCTA TGACGACCAT 
TTCCAGGGCT ACCTGGTGAC GCAGGCGGTG CAGCCCTCAG CCCAGGGGCC GGCAGAGACG 
CTTGAGATGT GGCTGATGCC CCAAGGGTCG CTGAAGCTGT TGGGGCGCAG TGACCAGGCC 
AGCCGGCTCC AGAGTCTGGA GGTTGGCACT GATTGGGACC CCAAAGAGCG TCTTTTCCGG 
AACTTTGGGG GGTTACTGGG GCCGCTGGAC GAGCCTGTGG CCGTGCAGCG CTGGGCCCGG 
GGCCCCAACC TCACAGCCAC AGTGGTCTGG ATCGACCCAA CCTATGTGGT GGCCACATCT 
TATGACATCA CAGTAGATAC GGAGACTGAG GTCACGCAAT ACAAGCCCCC ACTGAGCCGG 
CCCCTGCGGC CAGGGCCCTG GACTGTTCGA CTCCTTCAGT TCTGGGAACC GCTGGGTGAG 
ACCCGCTTCC TTGTGCTGCC CTTGACCTTC AACCGCAAAC TACCTCTCAG GAAAGATGAT 
GCCAGCTGGC TGCACGCAGG GCCACCCCAC AACGAGTACA TGGAGCAGAG TTTCCAGGGC 
CTGAGTAGCA TCCTGAACCT GCCTCAGCCG GAGCTCGCGG AGGAGGCTGC CCAGCGGCAC 
ACACAGCTCA CAGGCCCTGC GCTCGAGGCC TGGACAGACA GGGAACTGAG CAGCTTCTGG 
TCCGTGGCTG GACTGTGTGC CATAGGCCCC TCTCCCTGCC CCTCCCTGGA GCCCTGCAGA 
CTGACCAGCT GGAGCTCTCT GTCCCCCGAC CCCAAATCAG AGCTGGGGCC TGTCAAAGCA 
GACGGGCGAC TCAGGTAG

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_071450.2
CDS	16..2613
Translation	MVASARVQKLVRRYKLAIATALAILLLQGLVVWSFSGLEEDEAGEKGRQRKPRPLDPGEGSKDTDSSAGRRGSTGRRHGRWRGRAESPGVPVAKVVRAVTSRQRASRRVPPAPPPEAPGRQNLSGAAAGEALVGAAGFPPHGDTGSVEGAPQPTDNGFTPKCEIVGKDALSALARASTKQCQQEIANVVCLHQAGSLMPKAVPRHCQLTGKMSPGIQWDESQAQQPMDGPPVRIAYMLVVHGRAIRQLKRLLKAVYHEQHFFYIHVDKRSDYLHREVVELAQGYDNVRVTPWRMVTIWGGASLLRMYLRSMRDLLEVPGWAWDFFINLSATDYPTRTNEELVAFLSKNRDKNFLKSHGRDNSRFIKKQGLDRLFHECDSHMWRLGERQIPAGIVVDGGSDWFVLTRSFVEYVVYTDDPLVAQLRQFYTYTLLPAESFFHTVLENSLACETLVDNNLRVTNWNRKLGCKCQYKHIVDWCGCSPNDFKPQDFLRLQQVSRPTFFARKFESTVNQEVLEILDFHLYGSYPPGTPALKAYWENTYDAADGPSGLSDVMLTAYTAFARLSLHHAATAAPPMGTPLCRFEPRGLPSSVHLYFYDDHFQGYLVTQAVQPSAQGPAETLEMWLMPQGSLKLLGRSDQASRLQSLEVGTDWDPKERLFRNFGGLLGPLDEPVAVQRWARGPNLTATVVWIDPTYVVATSYDITVDTETEVTQYKPPLSRPLRPGPWTVRLLQFWEPLGETRFLVLPLTFNRKLPLRKDDASWLHAGPPHNEYMEQSFQGLSSILNLPQPELAEEAAQRHTQLTGPALEAWTDRELSSFWSVAGLCAIGPSPCPSLEPCRLTSWSSLSPDPKSELGPVKADGRLR

Target ORF information:

RefSeq Version	NM_022167.4
Organism	Homo sapiens(human)
Definition	Homo sapiens xylosyltransferase 2 (XYLT2), transcript variant 1, mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_022167.4

ORF Insert Sequence:

ATGGTGGCGA GCGCGCGAGT GCAGAAGCTG GTGCGGCGCT ACAAGCTGGC GATTGCCACG 
GCGCTGGCCA TCCTGCTGCT GCAGGGCCTG GTAGTGTGGA GCTTCAGCGG CCTGGAGGAG 
GACGAGGCGG GCGAGAAAGG AAGGCAGAGG AAGCCACGGC CACTGGACCC TGGCGAGGGT 
TCCAAGGACA CAGACAGTTC AGCAGGGCGA CGGGGCAGCA CAGGCAGAAG GCATGGGCGC 
TGGCGGGGCC GTGCTGAGAG CCCAGGAGTG CCCGTGGCCA AGGTGGTACG GGCAGTAACC 
AGCCGGCAGA GAGCCAGCCG GCGGGTCCCA CCTGCCCCAC CCCCGGAAGC CCCAGGCCGC 
CAGAACCTGA GTGGGGCAGC AGCTGGGGAG GCGCTGGTAG GGGCAGCTGG CTTCCCACCA 
CACGGAGATA CAGGGAGCGT GGAGGGCGCC CCCCAGCCCA CGGACAATGG CTTCACCCCC 
AAGTGCGAGA TCGTGGGCAA GGACGCACTG TCTGCACTGG CCCGGGCCAG CACCAAGCAG 
TGCCAGCAGG AGATCGCCAA TGTGGTGTGC CTGCACCAGG CTGGGAGCCT CATGCCCAAG 
GCTGTGCCCC GGCACTGTCA GCTGACTGGG AAGATGAGCC CCGGCATCCA GTGGGATGAG 
AGCCAAGCCC AGCAGCCCAT GGATGGCCCC CCGGTGCGAA TCGCCTACAT GCTGGTGGTT 
CACGGCCGCG CCATCCGCCA GCTGAAGCGT CTCCTCAAGG CCGTTTATCA CGAGCAGCAC 
TTCTTTTACA TCCATGTGGA CAAGCGTTCC GACTACCTGC ACCGGGAGGT GGTGGAGCTG 
GCCCAGGGCT ATGATAACGT GCGGGTGACG CCCTGGCGCA TGGTTACCAT CTGGGGCGGG 
GCCAGCCTCC TGAGGATGTA CCTGCGGAGC ATGCGGGACC TGCTAGAGGT GCCTGGCTGG 
GCCTGGGACT TCTTCATCAA CCTCAGTGCC ACTGACTATC CAACCAGGAC CAATGAGGAG 
CTGGTGGCAT TCCTATCCAA GAACCGGGAC AAGAATTTCC TCAAGTCACA TGGCCGGGAC 
AACTCCAGGT TCATCAAGAA ACAGGGCCTG GACCGGCTCT TCCATGAGTG CGACTCACAC 
ATGTGGCGCC TGGGCGAGCG GCAGATCCCA GCAGGCATTG TGGTGGATGG CGGTTCTGAC 
TGGTTCGTGC TGACACGCAG CTTTGTGGAG TATGTGGTGT ACACAGATGA CCCGCTTGTG 
GCCCAGCTGC GCCAGTTCTA CACATACACA CTGCTCCCAG CCGAGTCCTT CTTCCACACG 
GTGCTGGAGA ACAGCCTGGC CTGTGAGACC CTCGTGGACA ACAACCTGCG GGTCACCAAC 
TGGAACCGCA AGCTGGGCTG CAAGTGCCAG TACAAGCACA TTGTGGACTG GTGTGGCTGC 
TCCCCCAACG ACTTCAAGCC ACAGGACTTC CTCCGGCTGC AGCAAGTCTC CAGACCCACC 
TTCTTCGCCC GGAAGTTCGA GTCGACTGTG AACCAGGAGG TGCTGGAAAT CCTGGACTTC 
CACCTGTATG GCAGCTACCC CCCCGGCACG CCAGCCCTCA AGGCCTACTG GGAGAACACC 
TACGACGCGG CTGATGGCCC CAGTGGGCTC AGTGATGTCA TGCTCACTGC TTACACAGCC 
TTCGCCCGCC TCAGCCTGCA CCATGCCGCC ACTGCTGCAC CCCCAATGGG CACCCCACTC 
TGCAGGTTTG AGCCCAGGGG CTTGCCGTCC AGCGTGCACC TGTATTTCTA TGACGACCAT 
TTCCAGGGCT ACCTGGTGAC GCAGGCGGTG CAGCCCTCAG CCCAGGGGCC GGCAGAGACG 
CTTGAGATGT GGCTGATGCC CCAAGGGTCG CTGAAGCTGT TGGGGCGCAG TGACCAGGCC 
AGCCGGCTCC AGAGTCTGGA GGTTGGCACT GATTGGGACC CCAAAGAGCG TCTTTTCCGG 
AACTTTGGGG GGTTACTGGG GCCGCTGGAC GAGCCTGTGG CCGTGCAGCG CTGGGCCCGG 
GGCCCCAACC TCACAGCCAC AGTGGTCTGG ATCGACCCAA CCTATGTGGT GGCCACATCT 
TATGACATCA CAGTAGATAC GGAGACTGAG GTCACGCAAT ACAAGCCCCC ACTGAGCCGG 
CCCCTGCGGC CAGGGCCCTG GACTGTTCGA CTCCTTCAGT TCTGGGAACC GCTGGGTGAG 
ACCCGCTTCC TTGTGCTGCC CTTGACCTTC AACCGCAAAC TACCTCTCAG GAAAGATGAT 
GCCAGCTGGC TGCACGCAGG GCCACCCCAC AACGAGTACA TGGAGCAGAG TTTCCAGGGC 
CTGAGTAGCA TCCTGAACCT GCCTCAGCCG GAGCTCGCGG AGGAGGCTGC CCAGCGGCAC 
ACACAGCTCA CAGGCCCTGC GCTCGAGGCC TGGACAGACA GGGAACTGAG CAGCTTCTGG 
TCCGTGGCTG GACTGTGTGC CATAGGCCCC TCTCCCTGCC CCTCCCTGGA GCCCTGCAGA 
CTGACCAGCT GGAGCTCTCT GTCCCCCGAC CCCAAATCAG AGCTGGGGCC TGTCAAAGCA 
GACGGGCGAC TCAGGTAG

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

XYLT2 ( XM_005257572.4 ) cDNA ORF clone, Homo sapiens(human) -> XP_005257629.1 Homo sapiens xylosyltransferase 2 (XYLT2), transcript variant X1, mRNA.

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CloneID	OHu50579
Clone ID Related Accession (Same CDS sequence)	XM_005257572.4
Accession Version	XM_005257572.4 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 2502bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-12-05
Organism	Homo sapiens(human)
Product	xylosyltransferase 2 isoform X1
Comment	Comment: MODEL REFSEQ: This record is predicted by automated computational analysis. This record is derived from a genomic sequence (NC_000017.11) annotated using gene prediction method: Gnomon, supported by EST evidence. Also see: Documentation of NCBI's Annotation Process On Jun 6, 2016 this sequence version replaced XM_005257572.3. ##Genome-Annotation-Data-START## Annotation Provider :: NCBI Annotation Status :: Updated annotation Annotation Name :: Homo sapiens Updated Annotation Release 109.20191205 Annotation Version :: 109.20191205 Annotation Pipeline :: NCBI eukaryotic genome annotation pipeline Annotation Software Version :: 8.3 Annotation Method :: Best-placed RefSeq; propagated RefSeq model Features Annotated :: Gene; mRNA; CDS; ncRNA ##Genome-Annotation-Data-END##

ATGGGTCTCC GGAGGGCAGG GAGAGGAGGA ACTGAGCTGA AAGGAAGGCA GAGGAAGCCA 
CGGCCACTGG ACCCTGGCGA GGGTTCCAAG GACACAGACA GTTCAGCAGG GCGACGGGGC 
AGCACAGGCA GAAGGCATGG GCGCTGGCGG GGCCGTGCTG AGAGCCCAGG AGTGCCCGTG 
GCCAAGGTGG TACGGGCAGT AACCAGCCGG CAGAGAGCCA GCCGGCGGGT CCCACCTGCC 
CCACCCCCGG AAGCCCCAGG CCGCCAGAAC CTGAGTGGGG CAGCAGCTGG GGAGGCGCTG 
GTAGGGGCAG CTGGCTTCCC ACCACACGGA GATACAGGGA GCGTGGAGGG CGCCCCCCAG 
CCCACGGACA ATGGCTTCAC CCCCAAGTGC GAGATCGTGG GCAAGGACGC ACTGTCTGCA 
CTGGCCCGGG CCAGCACCAA GCAGTGCCAG CAGGAGATCG CCAATGTGGT GTGCCTGCAC 
CAGGCTGGGA GCCTCATGCC CAAGGCTGTG CCCCGGCACT GTCAGCTGAC TGGGAAGATG 
AGCCCCGGCA TCCAGTGGGA TGAGAGCCAA GCCCAGCAGC CCATGGATGG CCCCCCGGTG 
CGAATCGCCT ACATGCTGGT GGTTCACGGC CGCGCCATCC GCCAGCTGAA GCGTCTCCTC 
AAGGCCGTTT ATCACGAGCA GCACTTCTTT TACATCCATG TGGACAAGCG TTCCGACTAC 
CTGCACCGGG AGGTGGTGGA GCTGGCCCAG GGCTATGATA ACGTGCGGGT GACGCCCTGG 
CGCATGGTTA CCATCTGGGG CGGGGCCAGC CTCCTGAGGA TGTACCTGCG GAGCATGCGG 
GACCTGCTAG AGGTGCCTGG CTGGGCCTGG GACTTCTTCA TCAACCTCAG TGCCACTGAC 
TATCCAACCA GGACCAATGA GGAGCTGGTG GCATTCCTAT CCAAGAACCG GGACAAGAAT 
TTCCTCAAGT CACATGGCCG GGACAACTCC AGGTTCATCA AGAAACAGGG CCTGGACCGG 
CTCTTCCATG AGTGCGACTC ACACATGTGG CGCCTGGGCG AGCGGCAGAT CCCAGCAGGC 
ATTGTGGTGG ATGGCGGTTC TGACTGGTTC GTGCTGACAC GCAGCTTTGT GGAGTATGTG 
GTGTACACAG ATGACCCGCT TGTGGCCCAG CTGCGCCAGT TCTACACATA CACACTGCTC 
CCAGCCGAGT CCTTCTTCCA CACGGTGCTG GAGAACAGCC TGGCCTGTGA GACCCTCGTG 
GACAACAACC TGCGGGTCAC CAACTGGAAC CGCAAGCTGG GCTGCAAGTG CCAGTACAAG 
CACATTGTGG ACTGGTGTGG CTGCTCCCCC AACGACTTCA AGCCACAGGA CTTCCTCCGG 
CTGCAGCAAG TCTCCAGACC CACCTTCTTC GCCCGGAAGT TCGAGTCGAC TGTGAACCAG 
GAGGTGCTGG AAATCCTGGA CTTCCACCTG TATGGCAGCT ACCCCCCCGG CACGCCAGCC 
CTCAAGGCCT ACTGGGAGAA CACCTACGAC GCGGCTGATG GCCCCAGTGG GCTCAGTGAT 
GTCATGCTCA CTGCTTACAC AGCCTTCGCC CGCCTCAGCC TGCACCATGC CGCCACTGCT 
GCACCCCCAA TGGGCACCCC ACTCTGCAGG TTTGAGCCCA GGGGCTTGCC GTCCAGCGTG 
CACCTGTATT TCTATGACGA CCATTTCCAG GGCTACCTGG TGACGCAGGC GGTGCAGCCC 
TCAGCCCAGG GGCCGGCAGA GACGCTTGAG ATGTGGCTGA TGCCCCAAGG GTCGCTGAAG 
CTGTTGGGGC GCAGTGACCA GGCCAGCCGG CTCCAGAGTC TGGAGGTTGG CACTGATTGG 
GACCCCAAAG AGCGTCTTTT CCGGAACTTT GGGGGGTTAC TGGGGCCGCT GGACGAGCCT 
GTGGCCGTGC AGCGCTGGGC CCGGGGCCCC AACCTCACAG CCACAGTGGT CTGGATCGAC 
CCAACCTATG TGGTGGCCAC ATCTTATGAC ATCACAGTAG ATACGGAGAC TGAGGTCACG 
CAATACAAGC CCCCACTGAG CCGGCCCCTG CGGCCAGGGC CCTGGACTGT TCGACTCCTT 
CAGTTCTGGG AACCGCTGGG TGAGACCCGC TTCCTTGTGC TGCCCTTGAC CTTCAACCGC 
AAACTACCTC TCAGGAAAGA TGATGCCAGC TGGCTGCACG CAGGGCCACC CCACAACGAG 
TACATGGAGC AGAGTTTCCA GGGCCTGAGT AGCATCCTGA ACCTGCCTCA GCCGGAGCTC 
GCGGAGGAGG CTGCCCAGCG GCACACACAG CTCACAGGCC CTGCGCTCGA GGCCTGGACA 
GACAGGGAAC TGAGCAGCTT CTGGTCCGTG GCTGGACTGT GTGCCATAGG CCCCTCTCCC 
TGCCCCTCCC TGGAGCCCTG CAGACTGACC AGCTGGAGCT CTCTGTCCCC CGACCCCAAA 
TCAGAGCTGG GGCCTGTCAA AGCAGACGGG CGACTCAGGT AG

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	XP_005257629.1
CDS	520..3021
Translation	MGLRRAGRGGTELKGRQRKPRPLDPGEGSKDTDSSAGRRGSTGRRHGRWRGRAESPGVPVAKVVRAVTSRQRASRRVPPAPPPEAPGRQNLSGAAAGEALVGAAGFPPHGDTGSVEGAPQPTDNGFTPKCEIVGKDALSALARASTKQCQQEIANVVCLHQAGSLMPKAVPRHCQLTGKMSPGIQWDESQAQQPMDGPPVRIAYMLVVHGRAIRQLKRLLKAVYHEQHFFYIHVDKRSDYLHREVVELAQGYDNVRVTPWRMVTIWGGASLLRMYLRSMRDLLEVPGWAWDFFINLSATDYPTRTNEELVAFLSKNRDKNFLKSHGRDNSRFIKKQGLDRLFHECDSHMWRLGERQIPAGIVVDGGSDWFVLTRSFVEYVVYTDDPLVAQLRQFYTYTLLPAESFFHTVLENSLACETLVDNNLRVTNWNRKLGCKCQYKHIVDWCGCSPNDFKPQDFLRLQQVSRPTFFARKFESTVNQEVLEILDFHLYGSYPPGTPALKAYWENTYDAADGPSGLSDVMLTAYTAFARLSLHHAATAAPPMGTPLCRFEPRGLPSSVHLYFYDDHFQGYLVTQAVQPSAQGPAETLEMWLMPQGSLKLLGRSDQASRLQSLEVGTDWDPKERLFRNFGGLLGPLDEPVAVQRWARGPNLTATVVWIDPTYVVATSYDITVDTETEVTQYKPPLSRPLRPGPWTVRLLQFWEPLGETRFLVLPLTFNRKLPLRKDDASWLHAGPPHNEYMEQSFQGLSSILNLPQPELAEEAAQRHTQLTGPALEAWTDRELSSFWSVAGLCAIGPSPCPSLEPCRLTSWSSLSPDPKSELGPVKADGRLR

Target ORF information:

RefSeq Version	XM_005257572.4
Organism	Homo sapiens(human)
Definition	Homo sapiens xylosyltransferase 2 (XYLT2), transcript variant X1, mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

XM_005257572.4

ORF Insert Sequence:

ATGGGTCTCC GGAGGGCAGG GAGAGGAGGA ACTGAGCTGA AAGGAAGGCA GAGGAAGCCA 
CGGCCACTGG ACCCTGGCGA GGGTTCCAAG GACACAGACA GTTCAGCAGG GCGACGGGGC 
AGCACAGGCA GAAGGCATGG GCGCTGGCGG GGCCGTGCTG AGAGCCCAGG AGTGCCCGTG 
GCCAAGGTGG TACGGGCAGT AACCAGCCGG CAGAGAGCCA GCCGGCGGGT CCCACCTGCC 
CCACCCCCGG AAGCCCCAGG CCGCCAGAAC CTGAGTGGGG CAGCAGCTGG GGAGGCGCTG 
GTAGGGGCAG CTGGCTTCCC ACCACACGGA GATACAGGGA GCGTGGAGGG CGCCCCCCAG 
CCCACGGACA ATGGCTTCAC CCCCAAGTGC GAGATCGTGG GCAAGGACGC ACTGTCTGCA 
CTGGCCCGGG CCAGCACCAA GCAGTGCCAG CAGGAGATCG CCAATGTGGT GTGCCTGCAC 
CAGGCTGGGA GCCTCATGCC CAAGGCTGTG CCCCGGCACT GTCAGCTGAC TGGGAAGATG 
AGCCCCGGCA TCCAGTGGGA TGAGAGCCAA GCCCAGCAGC CCATGGATGG CCCCCCGGTG 
CGAATCGCCT ACATGCTGGT GGTTCACGGC CGCGCCATCC GCCAGCTGAA GCGTCTCCTC 
AAGGCCGTTT ATCACGAGCA GCACTTCTTT TACATCCATG TGGACAAGCG TTCCGACTAC 
CTGCACCGGG AGGTGGTGGA GCTGGCCCAG GGCTATGATA ACGTGCGGGT GACGCCCTGG 
CGCATGGTTA CCATCTGGGG CGGGGCCAGC CTCCTGAGGA TGTACCTGCG GAGCATGCGG 
GACCTGCTAG AGGTGCCTGG CTGGGCCTGG GACTTCTTCA TCAACCTCAG TGCCACTGAC 
TATCCAACCA GGACCAATGA GGAGCTGGTG GCATTCCTAT CCAAGAACCG GGACAAGAAT 
TTCCTCAAGT CACATGGCCG GGACAACTCC AGGTTCATCA AGAAACAGGG CCTGGACCGG 
CTCTTCCATG AGTGCGACTC ACACATGTGG CGCCTGGGCG AGCGGCAGAT CCCAGCAGGC 
ATTGTGGTGG ATGGCGGTTC TGACTGGTTC GTGCTGACAC GCAGCTTTGT GGAGTATGTG 
GTGTACACAG ATGACCCGCT TGTGGCCCAG CTGCGCCAGT TCTACACATA CACACTGCTC 
CCAGCCGAGT CCTTCTTCCA CACGGTGCTG GAGAACAGCC TGGCCTGTGA GACCCTCGTG 
GACAACAACC TGCGGGTCAC CAACTGGAAC CGCAAGCTGG GCTGCAAGTG CCAGTACAAG 
CACATTGTGG ACTGGTGTGG CTGCTCCCCC AACGACTTCA AGCCACAGGA CTTCCTCCGG 
CTGCAGCAAG TCTCCAGACC CACCTTCTTC GCCCGGAAGT TCGAGTCGAC TGTGAACCAG 
GAGGTGCTGG AAATCCTGGA CTTCCACCTG TATGGCAGCT ACCCCCCCGG CACGCCAGCC 
CTCAAGGCCT ACTGGGAGAA CACCTACGAC GCGGCTGATG GCCCCAGTGG GCTCAGTGAT 
GTCATGCTCA CTGCTTACAC AGCCTTCGCC CGCCTCAGCC TGCACCATGC CGCCACTGCT 
GCACCCCCAA TGGGCACCCC ACTCTGCAGG TTTGAGCCCA GGGGCTTGCC GTCCAGCGTG 
CACCTGTATT TCTATGACGA CCATTTCCAG GGCTACCTGG TGACGCAGGC GGTGCAGCCC 
TCAGCCCAGG GGCCGGCAGA GACGCTTGAG ATGTGGCTGA TGCCCCAAGG GTCGCTGAAG 
CTGTTGGGGC GCAGTGACCA GGCCAGCCGG CTCCAGAGTC TGGAGGTTGG CACTGATTGG 
GACCCCAAAG AGCGTCTTTT CCGGAACTTT GGGGGGTTAC TGGGGCCGCT GGACGAGCCT 
GTGGCCGTGC AGCGCTGGGC CCGGGGCCCC AACCTCACAG CCACAGTGGT CTGGATCGAC 
CCAACCTATG TGGTGGCCAC ATCTTATGAC ATCACAGTAG ATACGGAGAC TGAGGTCACG 
CAATACAAGC CCCCACTGAG CCGGCCCCTG CGGCCAGGGC CCTGGACTGT TCGACTCCTT 
CAGTTCTGGG AACCGCTGGG TGAGACCCGC TTCCTTGTGC TGCCCTTGAC CTTCAACCGC 
AAACTACCTC TCAGGAAAGA TGATGCCAGC TGGCTGCACG CAGGGCCACC CCACAACGAG 
TACATGGAGC AGAGTTTCCA GGGCCTGAGT AGCATCCTGA ACCTGCCTCA GCCGGAGCTC 
GCGGAGGAGG CTGCCCAGCG GCACACACAG CTCACAGGCC CTGCGCTCGA GGCCTGGACA 
GACAGGGAAC TGAGCAGCTT CTGGTCCGTG GCTGGACTGT GTGCCATAGG CCCCTCTCCC 
TGCCCCTCCC TGGAGCCCTG CAGACTGACC AGCTGGAGCT CTCTGTCCCC CGACCCCAAA 
TCAGAGCTGG GGCCTGTCAA AGCAGACGGG CGACTCAGGT AG

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

PubMed

Homozygous XYLT2 variants as a cause of spondyloocular syndrome.
Clinical genetics(2017 Nov)
Umair M,Eckstein G,Rudolph G,Strom T,Graf E,Hendig D,Hoover J,Alanay J,Meitinger T,Schmidt H,Ahmad W

Abnormal Proteoglycan Synthesis Due to Gene Defects Causes Skeletal Diseases with Overlapping Phenotypes.
Hormone and metabolic research = Hormon- und Stoffwechselforschung = Hormones et metabolisme48(11)745-754(2016 Nov)
Taylan F,M?kitie O

Spondyloocular Syndrome: Novel Mutations in XYLT2 Gene and Expansion of the Phenotypic Spectrum.
Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research31(8)1577-85(2016 Aug)
Taylan F,Costantini A,Coles N,Pekkinen M,H?on E,??klar Z,Berbero?lu M,K?mpe A,K?yk?m E,Grigelioniene G,T?ys?z B,M?kitie O

Homozygosity for frameshift mutations in XYLT2 result in a spondylo-ocular syndrome with bone fragility, cataracts, and hearing defects.
American journal of human genetics96(6)971-8(2015 Jun)
Munns CF,Fahiminiya S,Poudel N,Munteanu MC,Majewski J,Sillence DO,Metcalf JP,Biggin A,Glorieux F,Fassier F,Rauch F,Hinsdale ME

Xylosyltransferase II is the predominant isoenzyme which is responsible for the steady-state level of xylosyltransferase activity in human serum.
Biochemical and biophysical research communications459(3)469-74(2015 Apr)
Kuhn J,G?tting C,Beahm BJ,Bertozzi CR,Faust I,Kuzaj P,Knabbe C,Hendig D

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XYLT2 cDNA ORF clone, Homo sapiens(human)

Gene

Clones

gRNAs

Related articles in PubMed

Target ORF information:

Target ORF information:

ORF Insert Sequence:

Target ORF information:

Target ORF information:

ORF Insert Sequence:

Target ORF information:

Target ORF information:

ORF Insert Sequence:

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