FN3K cDNA ORF clone, Homo sapiens(human)

Gene
Clones
gRNAs

Summary

Gene Symbol	FN3K
Entrez Gene ID	64122
Full Name	fructosamine 3 kinase
General protein information	Preferred Names fructosamine 3 kinase Names fructosamine-3-kinase
Gene Type	protein-coding
Organism	Homo sapiens(human)
Genome	Chromosome: 17 Map Location: 17q25.3
Summary	A high concentration of glucose can result in non-enzymatic oxidation of proteins by reaction of glucose and lysine residues (glycation). Proteins modified in this way, fructosamines, are less active or functional. This gene encodes an enzyme which catalyzes the phosphorylation of fructosamines which may result in deglycation. [provided by RefSeq, Feb 2012].
Disorder MIM:	608425

mRNA and Protein(s)

mRNA	Protein	Name
NM_022158.3	NP_071441.1	fructosamine-3-kinase
NM_022158.4	NP_071441.1	fructosamine-3-kinase
XM_024450872.1	XP_024306640.1	fructosamine-3-kinase isoform X1

Pathways from BioSystems

Homologies

Mus musculus (house mouse)	Fn3k	NP_071297.1
Pan troglodytes (chimpanzee)	FN3K	XP_003315831.1
Canis lupus familiaris (dog)	FN3K	XP_005642233.1
Homo sapiens (human)	FN3K	NP_071441.1
Bos taurus (cattle)	FN3K	NP_001069650.1
Gallus gallus (chicken)	FN3K	XP_415601.1

Gene Ontology
Bibliography

Related articles in PubMed

The association between fructosamine-3 kinase 900C/G polymorphism, transferrin polymorphism and human herpesvirus-8 infection in diabetics living in South Kivu.
Cikomola JC, Vandepoele K, Katchunga PB, Kishabongo AS, Padalko EY, Speeckaert MM, Delanghe JR
Acta tropica16314-9(2016 Nov)

Possible role of fructosamine 3-kinase genotyping for the management of diabetic patients.
Avemaria F, Carrera P, Lapolla A, Sartore G, Chilelli NC, Paleari R, Ambrosi A, Ferrari M, Mosca A
Clinical chemistry and laboratory medicine53(9)1315-20(2015 Aug)

Multiple nonglycemic genomic loci are newly associated with blood level of glycated hemoglobin in East Asians.
Chen P, Takeuchi F, Lee JY, Li H, Wu JY, Liang J, Long J, Tabara Y, Goodarzi MO, Pereira MA, Kim YJ, Go MJ, Stram DO, Vithana E, Khor CC, Liu J, Liao J, Ye X, Wang Y, Lu L, Young TL, Lee J, Thai AC, Cheng CY, van Dam RM, Friedlander Y, Heng CK, Koh WP, Chen CH, Chang LC, Pan WH, Qi Q, Isono M, Zheng W, Cai Q, Gao Y, Yamamoto K, Ohnaka K, Takayanagi R, Kita Y, Ueshima H, Hsiung CA, Cui J, Sheu WH, Rotter JI, Chen YD, Hsu C, Okada Y, Kubo M, Takahashi A, Tanaka T, van Rooij FJ, Ganesh SK, Huang J, Huang T, Yuan J, Hwang JY, , Gross MD, Assimes TL, Miki T, Shu XO, Qi L, Chen YT, Lin X, Aung T, Wong TY, Teo YY, Kim BJ, Kato N, Tai ES
Diabetes63(7)2551-62(2014 Jul)

Fructosamine 3-kinase and glyoxalase I polymorphisms and their association with soluble RAGE and adhesion molecules in diabetes.
?krha J Jr, Muravsk? A, Fleka? M, Horov? E, Nov?k J, Novotn? A, Pr?zn? M, ?krha J, Kvasni?ka J, Landov? L, J?chymov? M, Zima T, Kalousov? M
Physiological research63 Suppl 2S283-91(2014)

Tissue distribution and evolution of fructosamine 3-kinase and fructosamine 3-kinase-related protein.
Delplanque J, Delpierre G, Opperdoes FR, Van Schaftingen E
The Journal of biological chemistry279(45)46606-13(2004 Nov)

GeneRIFs: Gene References Into Functions What's a GeneRIF?

In a multiple regression analysis, FN3K rs1056534, TF polymorphism and presence of diabetes mellitus were predictors for HHV-8 infection.
Title: The association between fructosamine-3 kinase 900C/G polymorphism, transferrin polymorphism and human herpesvirus-8 infection in diabetics living in South Kivu.

FN3K could act in concert with other molecular mechanisms and may impact on gene expression and activity of other enzymes involved in deglycation process
Title: Possible role of fructosamine 3-kinase genotyping for the management of diabetic patients.

The marginal association of rs1056534 of FN3K is located in exon 6 with diabetic nephropathy progression.
Title: Genetic variability in enzymes of metabolic pathways conferring protection against non-enzymatic glycation versus diabetes-related morbidity and mortality.

Report association of rs1056534 and rs3848403 of fructosamine 3-kinase gene with sRAGE in patients with diabetes.
Title: Fructosamine 3-kinase and glyoxalase I polymorphisms and their association with soluble RAGE and adhesion molecules in diabetes.

two new mutations and additional variants within the FN3K gene in diabetic patients
Title: Genetic variability of the fructosamine 3-kinase gene in diabetic patients.

The following FN3K gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the FN3K cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1⁺/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.

***CloneID	Accession No.	Definition	**Vector	*Turnaround time	Price (USD)
OHu107379	NM_022158.4 Latest version!	Homo sapiens fructosamine 3 kinase (FN3K), mRNA.	pcDNA3.1-C-(k)DYK or customized vector	9-11	$139.30 $199.00
OHu104451	XM_024450872.1 Latest version!	Homo sapiens fructosamine 3 kinase (FN3K), transcript variant X1, mRNA.	pcDNA3.1-C-(k)DYK or customized vector	9-11	$139.30 $199.00
OHu26302	NM_022158.3 Latest version!	Homo sapiens fructosamine 3 kinase (FN3K), mRNA.	pcDNA3.1-C-(k)DYK or customized vector	TBD	$216.30 $309.00

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** GenScript guarantees 100% sequence accuracy of all synthetic DNA constructs we deliver, but we do not guarantee protein expression in your experimental system. Protein expression is influenced by many factors that may vary between experiments or laboratories. In addition, please pay attention to the signal peptide, propeptide and transit peptide in target ORF, which may affect the choice of vector (N/C terminal tag vector).

***One clone ID might be correlated to multiple accession numbers, which share the same CDS sequence.

Reference Sequences (Refseq)

FN3K ( NM_022158.4 ) cDNA ORF clone, Homo sapiens(human) -> NP_071441.1 Homo sapiens fructosamine 3 kinase (FN3K), mRNA.

Price & Availability↑

CloneID	OHu107379
Clone ID Related Accession (Same CDS sequence)	NM_022158.4
Accession Version	NM_022158.4 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 930bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2020-01-01
Organism	Homo sapiens(human)
Product	fructosamine-3-kinase
Comment	Comment: VALIDATED REFSEQ: This record has undergone validation or preliminary review. The reference sequence was derived from AC024361.21. On Nov 24, 2018 this sequence version replaced NM_022158.3. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: SRR3476690.679976.1, SRR3476690.256366.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA1966682, SAMEA1968540 [ECO:0000348] ##Evidence-Data-END## ##RefSeq-Attributes-START## MANE Ensembl match :: ENST00000300784.8/ ENSP00000300784.7 RefSeq Select criteria :: based on conservation, expression, longest protein ##RefSeq-Attributes-END## COMPLETENESS: full length.

ATGGAGCAGC TGCTGCGCGC CGAGCTGCGC ACCGCGACCC TGCGGGCCTT CGGCGGCCCC 
GGCGCCGGCT GCATCAGCGA GGGCCGAGCC TACGACACGG ACGCAGGCCC AGTGTTCGTC 
AAAGTCAACC GCAGGACGCA GGCCCGGCAG ATGTTTGAGG GGGAGGTGGC CAGCCTGGAG 
GCCCTCAGGA GCACGGGCCT GGTGCGGGTG CCGAGGCCCA TGAAGGTCAT CGACCTGCCG 
GGAGGTGGGG CCGCCTTTGT GATGGAGCAT TTGAAGATGA AGAGCTTGAG CAGTCAAGCA 
TCAAAACTTG GAGAGCAGAT GGCAGATTTG CATCTTTACA ACCAGAAGCT CAGGGAGAAG 
TTGAAGGAGG AGGAGAACAC AGTGGGCCGA AGAGGTGAGG GTGCTGAGCC TCAGTATGTG 
GACAAGTTCG GCTTCCACAC GGTGACGTGC TGCGGCTTCA TCCCGCAGGT GAATGAGTGG 
CAGGATGACT GGCCGACCTT TTTCGCCCGG CACCGGCTCC AGGCGCAGCT GGACCTCATT 
GAGAAGGACT ATGCTGACCG AGAGGCACGA GAACTCTGGT CCCGGCTACA GGTGAAGATC 
CCGGATCTGT TTTGTGGCCT AGAGATTGTC CCCGCGTTGC TCCACGGGGA TCTCTGGTCG 
GGAAACGTGG CTGAGGACGA CGTGGGGCCC ATTATTTACG ACCCGGCTTC CTTCTATGGC 
CATTCCGAGT TTGAACTGGC AATCGCCTTG ATGTTTGGGG GGTTCCCCAG ATCCTTCTTC 
ACCGCCTACC ACCGGAAGAT CCCCAAGGCT CCGGGCTTCG ACCAGCGGCT GCTGCTCTAC 
CAGCTGTTTA ACTACCTGAA CCACTGGAAC CACTTCGGGC GGGAGTACAG GAGCCCTTCC 
TTGGGCACCA TGCGAAGGCT GCTCAAGTAG

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_071441.1
CDS	23..952
Translation	MEQLLRAELRTATLRAFGGPGAGCISEGRAYDTDAGPVFVKVNRRTQARQMFEGEVASLEALRSTGLVRVPRPMKVIDLPGGGAAFVMEHLKMKSLSSQASKLGEQMADLHLYNQKLREKLKEEENTVGRRGEGAEPQYVDKFGFHTVTCCGFIPQVNEWQDDWPTFFARHRLQAQLDLIEKDYADREARELWSRLQVKIPDLFCGLEIVPALLHGDLWSGNVAEDDVGPIIYDPASFYGHSEFELAIALMFGGFPRSFFTAYHRKIPKAPGFDQRLLLYQLFNYLNHWNHFGREYRSPSLGTMRRLLK

Target ORF information:

RefSeq Version	NM_022158.4
Organism	Homo sapiens(human)
Definition	Homo sapiens fructosamine 3 kinase (FN3K), mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_022158.4

ORF Insert Sequence:

ATGGAGCAGC TGCTGCGCGC CGAGCTGCGC ACCGCGACCC TGCGGGCCTT CGGCGGCCCC 
GGCGCCGGCT GCATCAGCGA GGGCCGAGCC TACGACACGG ACGCAGGCCC AGTGTTCGTC 
AAAGTCAACC GCAGGACGCA GGCCCGGCAG ATGTTTGAGG GGGAGGTGGC CAGCCTGGAG 
GCCCTCAGGA GCACGGGCCT GGTGCGGGTG CCGAGGCCCA TGAAGGTCAT CGACCTGCCG 
GGAGGTGGGG CCGCCTTTGT GATGGAGCAT TTGAAGATGA AGAGCTTGAG CAGTCAAGCA 
TCAAAACTTG GAGAGCAGAT GGCAGATTTG CATCTTTACA ACCAGAAGCT CAGGGAGAAG 
TTGAAGGAGG AGGAGAACAC AGTGGGCCGA AGAGGTGAGG GTGCTGAGCC TCAGTATGTG 
GACAAGTTCG GCTTCCACAC GGTGACGTGC TGCGGCTTCA TCCCGCAGGT GAATGAGTGG 
CAGGATGACT GGCCGACCTT TTTCGCCCGG CACCGGCTCC AGGCGCAGCT GGACCTCATT 
GAGAAGGACT ATGCTGACCG AGAGGCACGA GAACTCTGGT CCCGGCTACA GGTGAAGATC 
CCGGATCTGT TTTGTGGCCT AGAGATTGTC CCCGCGTTGC TCCACGGGGA TCTCTGGTCG 
GGAAACGTGG CTGAGGACGA CGTGGGGCCC ATTATTTACG ACCCGGCTTC CTTCTATGGC 
CATTCCGAGT TTGAACTGGC AATCGCCTTG ATGTTTGGGG GGTTCCCCAG ATCCTTCTTC 
ACCGCCTACC ACCGGAAGAT CCCCAAGGCT CCGGGCTTCG ACCAGCGGCT GCTGCTCTAC 
CAGCTGTTTA ACTACCTGAA CCACTGGAAC CACTTCGGGC GGGAGTACAG GAGCCCTTCC 
TTGGGCACCA TGCGAAGGCT GCTCAAGTAG

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

FN3K ( XM_024450872.1 ) cDNA ORF clone, Homo sapiens(human) -> XP_024306640.1 Homo sapiens fructosamine 3 kinase (FN3K), transcript variant X1, mRNA.

Price & Availability↑

CloneID	OHu104451
Clone ID Related Accession (Same CDS sequence)	XM_024450872.1
Accession Version	XM_024450872.1 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 780bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-12-05
Organism	Homo sapiens(human)
Product	fructosamine-3-kinase isoform X1
Comment	Comment: MODEL REFSEQ: This record is predicted by automated computational analysis. This record is derived from a genomic sequence (NC_000017.11) annotated using gene prediction method: Gnomon, supported by EST evidence. Also see: Documentation of NCBI's Annotation Process ##Genome-Annotation-Data-START## Annotation Provider :: NCBI Annotation Status :: Updated annotation Annotation Name :: Homo sapiens Updated Annotation Release 109.20191205 Annotation Version :: 109.20191205 Annotation Pipeline :: NCBI eukaryotic genome annotation pipeline Annotation Software Version :: 8.3 Annotation Method :: Best-placed RefSeq; propagated RefSeq model Features Annotated :: Gene; mRNA; CDS; ncRNA ##Genome-Annotation-Data-END##

ATGTTTGAGG GGGAGGTGGC CAGCCTGGAG GCCCTCAGGA GCACGGGCCT GGTGCGGGTG 
CCGAGGCCCA TGAAGGTCAT CGACCTGCCG GGAGGTGGGG CCGCCTTTGT GATGGAGCAT 
TTGAAGATGA AGAGCTTGAG CAGTCAAGCA TCAAAACTTG GAGAGCAGAT GGCAGATTTG 
CATCTTTACA ACCAGAAGCT CAGGGAGAAG TTGAAGGAGG AGGAGAACAC AGTGGGCCGA 
AGAGGTGAGG GTGCTGAGCC TCAGTATGTG GACAAGTTCG GCTTCCACAC GGTGACGTGC 
TGCGGCTTCA TCCCGCAGGT GAATGAGTGG CAGGATGACT GGCCGACCTT TTTCGCCCGG 
CACCGGCTCC AGGCGCAGCT GGACCTCATT GAGAAGGACT ATGCTGACCG AGAGGCACGA 
GAACTCTGGT CCCGGCTACA GGTGAAGATC CCGGATCTGT TTTGTGGCCT AGAGATTGTC 
CCCGCGTTGC TCCACGGGGA TCTCTGGTCG GGAAACGTGG CTGAGGACGA CGTGGGGCCC 
ATTATTTACG ACCCGGCTTC CTTCTATGGC CATTCCGAGT TTGAACTGGC AATCGCCTTG 
ATGTTTGGGG GGTTCCCCAG ATCCTTCTTC ACCGCCTACC ACCGGAAGAT CCCCAAGGCT 
CCGGGCTTCG ACCAGCGGCT GCTGCTCTAC CAGCTGTTTA ACTACCTGAA CCACTGGAAC 
CACTTCGGGC GGGAGTACAG GAGCCCTTCC TTGGGCACCA TGCGAAGGCT GCTCAAGTAG

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	XP_024306640.1
CDS	411..1190
Translation	MFEGEVASLEALRSTGLVRVPRPMKVIDLPGGGAAFVMEHLKMKSLSSQASKLGEQMADLHLYNQKLREKLKEEENTVGRRGEGAEPQYVDKFGFHTVTCCGFIPQVNEWQDDWPTFFARHRLQAQLDLIEKDYADREARELWSRLQVKIPDLFCGLEIVPALLHGDLWSGNVAEDDVGPIIYDPASFYGHSEFELAIALMFGGFPRSFFTAYHRKIPKAPGFDQRLLLYQLFNYLNHWNHFGREYRSPSLGTMRRLLK

Target ORF information:

RefSeq Version	XM_024450872.1
Organism	Homo sapiens(human)
Definition	Homo sapiens fructosamine 3 kinase (FN3K), transcript variant X1, mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

XM_024450872.1

ORF Insert Sequence:

ATGTTTGAGG GGGAGGTGGC CAGCCTGGAG GCCCTCAGGA GCACGGGCCT GGTGCGGGTG 
CCGAGGCCCA TGAAGGTCAT CGACCTGCCG GGAGGTGGGG CCGCCTTTGT GATGGAGCAT 
TTGAAGATGA AGAGCTTGAG CAGTCAAGCA TCAAAACTTG GAGAGCAGAT GGCAGATTTG 
CATCTTTACA ACCAGAAGCT CAGGGAGAAG TTGAAGGAGG AGGAGAACAC AGTGGGCCGA 
AGAGGTGAGG GTGCTGAGCC TCAGTATGTG GACAAGTTCG GCTTCCACAC GGTGACGTGC 
TGCGGCTTCA TCCCGCAGGT GAATGAGTGG CAGGATGACT GGCCGACCTT TTTCGCCCGG 
CACCGGCTCC AGGCGCAGCT GGACCTCATT GAGAAGGACT ATGCTGACCG AGAGGCACGA 
GAACTCTGGT CCCGGCTACA GGTGAAGATC CCGGATCTGT TTTGTGGCCT AGAGATTGTC 
CCCGCGTTGC TCCACGGGGA TCTCTGGTCG GGAAACGTGG CTGAGGACGA CGTGGGGCCC 
ATTATTTACG ACCCGGCTTC CTTCTATGGC CATTCCGAGT TTGAACTGGC AATCGCCTTG 
ATGTTTGGGG GGTTCCCCAG ATCCTTCTTC ACCGCCTACC ACCGGAAGAT CCCCAAGGCT 
CCGGGCTTCG ACCAGCGGCT GCTGCTCTAC CAGCTGTTTA ACTACCTGAA CCACTGGAAC 
CACTTCGGGC GGGAGTACAG GAGCCCTTCC TTGGGCACCA TGCGAAGGCT GCTCAAGTAG

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

FN3K ( NM_022158.3 ) cDNA ORF clone, Homo sapiens(human) -> NP_071441.1 Homo sapiens fructosamine 3 kinase (FN3K), mRNA.

Price & Availability↑

CloneID	OHu26302
Clone ID Related Accession (Same CDS sequence)	NM_022158.3
Accession Version	NM_022158.3 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 930bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2017-10-01
Organism	Homo sapiens(human)
Product	fructosamine-3-kinase
Comment	Comment: VALIDATED REFSEQ: This record has undergone validation or preliminary review. The reference sequence was derived from AC024361.21 and BC042680.1. On Jan 6, 2009 this sequence version replaced NM_022158.2. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: BC042680.1, ERR279847.1090.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA1966682, SAMEA1968540 [ECO:0000348] ##Evidence-Data-END## COMPLETENESS: complete on the 3' end.

ATGGAGCAGC TGCTGCGCGC CGAGCTGCGC ACCGCGACCC TGCGGGCCTT CGGCGGCCCC 
GGCGCCGGCT GCATCAGCGA GGGCCGAGCC TACGACACGG ACGCAGGCCC AGTGTTCGTC 
AAAGTCAACC GCAGGACGCA GGCCCGGCAG ATGTTTGAGG GGGAGGTGGC CAGCCTGGAG 
GCCCTCCGGA GCACGGGCCT GGTGCGGGTG CCGAGGCCCA TGAAGGTCAT CGACCTGCCG 
GGAGGTGGGG CCGCCTTTGT GATGGAGCAT TTGAAGATGA AGAGCTTGAG CAGTCAAGCA 
TCAAAACTTG GAGAGCAGAT GGCAGATTTG CATCTTTACA ACCAGAAGCT CAGGGAGAAG 
TTGAAGGAGG AGGAGAACAC AGTGGGCCGA AGAGGTGAGG GTGCTGAGCC TCAGTATGTG 
GACAAGTTCG GCTTCCACAC GGTGACGTGC TGCGGCTTCA TCCCGCAGGT GAATGAGTGG 
CAGGATGACT GGCCGACCTT TTTCGCCCGG CACCGGCTCC AGGCGCAGCT GGACCTCATT 
GAGAAGGACT ATGCTGACCG AGAGGCACGA GAACTCTGGT CCCGGCTACA GGTGAAGATC 
CCGGATCTGT TTTGTGGCCT AGAGATTGTC CCCGCGTTGC TCCACGGGGA TCTCTGGTCG 
GGAAACGTGG CTGAGGACGA CGTGGGGCCC ATTATTTACG ACCCGGCTTC CTTCTATGGC 
CATTCCGAGT TTGAACTGGC AATCGCCTTG ATGTTTGGGG GGTTCCCCAG ATCCTTCTTC 
ACCGCCTACC ACCGGAAGAT CCCCAAGGCT CCGGGCTTCG ACCAGCGGCT GCTGCTCTAC 
CAGCTGTTTA ACTACCTGAA CCACTGGAAC CACTTCGGGC GGGAGTACAG GAGCCCTTCC 
TTGGGCACCA TGCGAAGGCT GCTCAAGTAG

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_071441.1
CDS	62..991
Translation	MEQLLRAELRTATLRAFGGPGAGCISEGRAYDTDAGPVFVKVNRRTQARQMFEGEVASLEALRSTGLVRVPRPMKVIDLPGGGAAFVMEHLKMKSLSSQASKLGEQMADLHLYNQKLREKLKEEENTVGRRGEGAEPQYVDKFGFHTVTCCGFIPQVNEWQDDWPTFFARHRLQAQLDLIEKDYADREARELWSRLQVKIPDLFCGLEIVPALLHGDLWSGNVAEDDVGPIIYDPASFYGHSEFELAIALMFGGFPRSFFTAYHRKIPKAPGFDQRLLLYQLFNYLNHWNHFGREYRSPSLGTMRRLLK

Target ORF information:

RefSeq Version	NM_022158.3
Organism	Homo sapiens(human)
Definition	Homo sapiens fructosamine 3 kinase (FN3K), mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_022158.3

ORF Insert Sequence:

ATGGAGCAGC TGCTGCGCGC CGAGCTGCGC ACCGCGACCC TGCGGGCCTT CGGCGGCCCC 
GGCGCCGGCT GCATCAGCGA GGGCCGAGCC TACGACACGG ACGCAGGCCC AGTGTTCGTC 
AAAGTCAACC GCAGGACGCA GGCCCGGCAG ATGTTTGAGG GGGAGGTGGC CAGCCTGGAG 
GCCCTCCGGA GCACGGGCCT GGTGCGGGTG CCGAGGCCCA TGAAGGTCAT CGACCTGCCG 
GGAGGTGGGG CCGCCTTTGT GATGGAGCAT TTGAAGATGA AGAGCTTGAG CAGTCAAGCA 
TCAAAACTTG GAGAGCAGAT GGCAGATTTG CATCTTTACA ACCAGAAGCT CAGGGAGAAG 
TTGAAGGAGG AGGAGAACAC AGTGGGCCGA AGAGGTGAGG GTGCTGAGCC TCAGTATGTG 
GACAAGTTCG GCTTCCACAC GGTGACGTGC TGCGGCTTCA TCCCGCAGGT GAATGAGTGG 
CAGGATGACT GGCCGACCTT TTTCGCCCGG CACCGGCTCC AGGCGCAGCT GGACCTCATT 
GAGAAGGACT ATGCTGACCG AGAGGCACGA GAACTCTGGT CCCGGCTACA GGTGAAGATC 
CCGGATCTGT TTTGTGGCCT AGAGATTGTC CCCGCGTTGC TCCACGGGGA TCTCTGGTCG 
GGAAACGTGG CTGAGGACGA CGTGGGGCCC ATTATTTACG ACCCGGCTTC CTTCTATGGC 
CATTCCGAGT TTGAACTGGC AATCGCCTTG ATGTTTGGGG GGTTCCCCAG ATCCTTCTTC 
ACCGCCTACC ACCGGAAGAT CCCCAAGGCT CCGGGCTTCG ACCAGCGGCT GCTGCTCTAC 
CAGCTGTTTA ACTACCTGAA CCACTGGAAC CACTTCGGGC GGGAGTACAG GAGCCCTTCC 
TTGGGCACCA TGCGAAGGCT GCTCAAGTAG

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

PubMed

The association between fructosamine-3 kinase 900C/G polymorphism, transferrin polymorphism and human herpesvirus-8 infection in diabetics living in South Kivu.
Acta tropica16314-9(2016 Nov)
Cikomola JC,Vandepoele K,Katchunga PB,Kishabongo AS,Padalko EY,Speeckaert MM,Delanghe JR

Possible role of fructosamine 3-kinase genotyping for the management of diabetic patients.
Clinical chemistry and laboratory medicine53(9)1315-20(2015 Aug)
Avemaria F,Carrera P,Lapolla A,Sartore G,Chilelli NC,Paleari R,Ambrosi A,Ferrari M,Mosca A

Multiple nonglycemic genomic loci are newly associated with blood level of glycated hemoglobin in East Asians.
Diabetes63(7)2551-62(2014 Jul)
Chen P,Takeuchi F,Lee JY,Li H,Wu JY,Liang J,Long J,Tabara Y,Goodarzi MO,Pereira MA,Kim YJ,Go MJ,Stram DO,Vithana E,Khor CC,Liu J,Liao J,Ye X,Wang Y,Lu L,Young TL,Lee J,Thai AC,Cheng CY,van Dam RM,Friedlander Y,Heng CK,Koh WP,Chen CH,Chang LC,Pan WH,Qi Q,Isono M,Zheng W,Cai Q,Gao Y,Yamamoto K,Ohnaka K,Takayanagi R,Kita Y,Ueshima H,Hsiung CA,Cui J,Sheu WH,Rotter JI,Chen YD,Hsu C,Okada Y,Kubo M,Takahashi A,Tanaka T,van Rooij FJ,Ganesh SK,Huang J,Huang T,Yuan J,Hwang JY,,Gross MD,Assimes TL,Miki T,Shu XO,Qi L,Chen YT,Lin X,Aung T,Wong TY,Teo YY,Kim BJ,Kato N,Tai ES

Fructosamine 3-kinase and glyoxalase I polymorphisms and their association with soluble RAGE and adhesion molecules in diabetes.
Physiological research63 Suppl 2S283-91(2014)
?krha J Jr,Muravsk? A,Fleka? M,Horov? E,Nov?k J,Novotn? A,Pr?zn? M,?krha J,Kvasni?ka J,Landov? L,J?chymov? M,Zima T,Kalousov? M

Tissue distribution and evolution of fructosamine 3-kinase and fructosamine 3-kinase-related protein.
The Journal of biological chemistry279(45)46606-13(2004 Nov)
Delplanque J,Delpierre G,Opperdoes FR,Van Schaftingen E

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FN3K cDNA ORF clone, Homo sapiens(human)

Gene

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gRNAs

Related articles in PubMed

Target ORF information:

Target ORF information:

ORF Insert Sequence:

Target ORF information:

Target ORF information:

ORF Insert Sequence:

Target ORF information:

Target ORF information:

ORF Insert Sequence:

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