LRRC4 cDNA ORF clone, Homo sapiens(human)

Gene
Clones
gRNAs

Summary

Gene Symbol	LRRC4
Entrez Gene ID	64101
Full Name	leucine rich repeat containing 4
Synonyms	NAG14,NGL-2
General protein information	Preferred Names leucine rich repeat containing 4 Names leucine-rich repeat-containing protein 4 brain tumor associated protein LRRC4 brain tumor-associated protein BAG nasopharyngeal carcinoma-associated gene 14 protein netrin-G2 ligand
Gene Type	protein-coding
Organism	Homo sapiens(human)
Genome	Chromosome: 7 Map Location: 7q32.1
Summary	This gene is significantly downregulated in primary brain tumors. The exact function of the protein encoded by this gene is unknown. [provided by RefSeq, Jul 2008].
Disorder MIM:	610486

mRNA and Protein(s)

mRNA	Protein	Name
NM_022143.4	NP_071426.1	leucine-rich repeat-containing protein 4 precursor
XM_017012505.1	XP_016867994.1	leucine-rich repeat-containing protein 4 isoform X1
XM_011516461.3	XP_011514763.1	leucine-rich repeat-containing protein 4 isoform X1
XM_011516461.2	XP_011514763.1	leucine-rich repeat-containing protein 4 isoform X1
XM_011516461.1	XP_011514763.1	leucine-rich repeat-containing protein 4 isoform X1
NM_022143.5	NP_071426.1	leucine-rich repeat-containing protein 4 precursor

Pathways from BioSystems

Homologies

	LRRC4	XP_001090221.1
Mus musculus (house mouse)	Lrrc4	NP_619623.2
Rattus norvegicus (Norway rat)	Lrrc4	NP_001032413.1
Xenopus tropicalis (tropical clawed frog)	lrrc4	XP_002939414.1
Pan troglodytes (chimpanzee)	LRRC4	XP_001151566.1
Bos taurus (cattle)	LRRC4	NP_001014938.1
Danio rerio (zebrafish)	LOC566572	NP_001093494.1
Homo sapiens (human)	LRRC4	NP_071426.1
Canis lupus familiaris (dog)	LRRC4	XP_849461.1

Gene Ontology
Bibliography

Related articles in PubMed

The D Domain of LRRC4 anchors ERK1/2 in the cytoplasm and competitively inhibits MEK/ERK activation in glioma cells.
Wang Z, Guo Q, Wang R, Xu G, Li P, Sun Y, She X, Liu Q, Chen Q, Yu Z, Liu C, Xiong J, Li G, Wu M
Journal of hematology & oncology9(1)130(2016 11)

Low expression of miR-381 is a favorite prognosis factor and enhances the chemosensitivity of osteosarcoma.
Li Y, Zhao C, Yu Z, Chen J, She X, Li P, Liu C, Zhang Y, Feng J, Fu H, Wang B, Kuang L, Li L, Lv G, Wu M
Oncotarget7(42)68585-68596(2016 Oct)

LRRC4 haplotypes are associated with pituitary adenoma in a Chinese population.
Xiao L, Tu C, Chen S, Yu Z, Lei Q, Wang Z, Xu G, Wu M, Li G
Medical oncology (Northwood, London, England)31(4)888(2014 Apr)

Disturbing miR-182 and -381 inhibits BRD7 transcription and glioma growth by directly targeting LRRC4.
Tang H, Wang Z, Liu Q, Liu X, Wu M, Li G
PloS one9(1)e84146(2014)

LRRC4 inhibits glioma cell growth and invasion through a miR-185-dependent pathway.
Tang H, Wang Z, Liu X, Liu Q, Xu G, Li G, Wu M
Current cancer drug targets12(8)1032-42(2012 Oct)

GeneRIFs: Gene References Into Functions What's a GeneRIF?

Following EGF stimuli, the D domain of LRRC4 anchors ERK1/2 in the cytoplasm and abrogates ERK1/2 activation and nuclear translocation.
Title: The D Domain of LRRC4 anchors ERK1/2 in the cytoplasm and competitively inhibits MEK/ERK activation in glioma cells.

polymorphisms and haplotypes in the LRRC4 may have a role in pituitary adenoma in a Chinese population
Title: LRRC4 haplotypes are associated with pituitary adenoma in a Chinese population.

Disturbing miR-182 and -381 inhibits BRD7 transcription and glioma growth by directly targeting LRRC4.
Title: Disturbing miR-182 and -381 inhibits BRD7 transcription and glioma growth by directly targeting LRRC4.

LRRC4 inhibited the miR-185 pathway function in glioma
Title: LRRC4 inhibits glioma cell growth and invasion through a miR-185-dependent pathway.

Potentially, modulation of LRRC4 or STMN1 expression may be useful for design of new therapies for the intervention of glioma
Title: LRRC4 inhibits the proliferation of human glioma cells by modulating the expression of STMN1 and microtubule polymerization.

The following LRRC4 gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the LRRC4 cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1⁺/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.

***CloneID	Accession No.	Definition	**Vector	*Turnaround time	Price (USD)
OHu30186	NM_022143.5 Latest version!	Homo sapiens leucine rich repeat containing 4 (LRRC4), mRNA.	pcDNA3.1-C-(k)DYK or customized vector	in pcDNA3.1-C-(k)DYK	$189.50-$265.30 $379.00
OHu30186	XM_011516461.3 Latest version!	Homo sapiens leucine rich repeat containing 4 (LRRC4), transcript variant X1, mRNA.	pcDNA3.1-C-(k)DYK or customized vector	in pcDNA3.1-C-(k)DYK	$189.50-$265.30 $379.00
OHu30186	XM_017012505.1 Latest version!	Homo sapiens leucine rich repeat containing 4 (LRRC4), transcript variant X1, mRNA.	pcDNA3.1-C-(k)DYK or customized vector	in pcDNA3.1-C-(k)DYK	$189.50-$265.30 $379.00
View Old Accession Versions >>
OHu30186	XM_011516461.2	Homo sapiens leucine rich repeat containing 4 (LRRC4), transcript variant X2, mRNA.	pcDNA3.1-C-(k)DYK or customized vector	in pcDNA3.1-C-(k)DYK	$189.50-$265.30 $379.00
OHu30186	XM_011516461.1	Homo sapiens leucine rich repeat containing 4 (LRRC4), transcript variant X1, mRNA.	pcDNA3.1-C-(k)DYK or customized vector	in pcDNA3.1-C-(k)DYK	$189.50-$265.30 $379.00
OHu30186	NM_022143.4	Homo sapiens leucine rich repeat containing 4 (LRRC4), mRNA.	pcDNA3.1-C-(k)DYK or customized vector	in pcDNA3.1-C-(k)DYK	$189.50-$265.30 $379.00
Hide Old Accession Versions >>

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** GenScript guarantees 100% sequence accuracy of all synthetic DNA constructs we deliver, but we do not guarantee protein expression in your experimental system. Protein expression is influenced by many factors that may vary between experiments or laboratories. In addition, please pay attention to the signal peptide, propeptide and transit peptide in target ORF, which may affect the choice of vector (N/C terminal tag vector).

***One clone ID might be correlated to multiple accession numbers, which share the same CDS sequence.

Reference Sequences (Refseq)

LRRC4 ( NM_022143.4 ) cDNA ORF clone, Homo sapiens(human) -> NP_071426.1 Homo sapiens leucine rich repeat containing 4 (LRRC4), mRNA.

Price & Availability↑

CloneID	OHu30186
Clone ID Related Accession (Same CDS sequence)	NM_022143.4 , XM_017012505.1 , XM_011516461.3 , XM_011516461.2 , XM_011516461.1 , NM_022143.5
Accession Version	NM_022143.4	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 1962bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2017-11-29
Organism	Homo sapiens(human)
Product	leucine-rich repeat-containing protein 4 precursor
Comment	Comment: VALIDATED REFSEQ: This record has undergone validation or preliminary review. The reference sequence was derived from AF196976.4, BC111745.1 and BU682120.1. On Oct 14, 2006 this sequence version replaced NM_022143.3. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: AF196976.4, BC111561.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA1965299, SAMEA1966682 [ECO:0000348] ##Evidence-Data-END## COMPLETENESS: complete on the 3' end.

ATGAAGCTCT TGTGGCAGGT AACTGTGCAC CACCACACCT GGAATGCCAT CCTGCTCCCG 
TTCGTCTACC TCACGGCGCA AGTGTGGATT CTGTGTGCAG CCATCGCTGC TGCCGCCTCA 
GCCGGGCCCC AGAACTGCCC CTCCGTCTGC TCGTGCAGTA ACCAGTTCAG CAAGGTGGTG 
TGCACGCGCC GGGGCCTCTC CGAGGTCCCG CAGGGTATTC CCTCGAACAC CCGGTACCTC 
AACCTCATGG AGAACAACAT CCAGATGATC CAGGCCGACA CCTTCCGCCA CCTCCACCAC 
CTGGAGGTCC TGCAGTTGGG CAGGAACTCC ATCCGGCAGA TTGAGGTGGG GGCCTTCAAC 
GGCCTGGCCA GCCTCAACAC CCTGGAGCTG TTCGACAACT GGCTGACAGT CATCCCTAGC 
GGGGCCTTTG AATACCTGTC CAAGCTGCGG GAGCTCTGGC TTCGCAACAA CCCCATCGAA 
AGCATCCCCT CTTACGCCTT CAACCGGGTG CCCTCCCTCA TGCGCCTGGA CTTGGGGGAG 
CTCAAGAAGC TGGAGTATAT CTCTGAGGGA GCTTTTGAGG GGCTGTTCAA CCTCAAGTAT 
CTGAACTTGG GCATGTGCAA CATTAAAGAC ATGCCCAATC TCACCCCCCT GGTGGGGCTG 
GAGGAGCTGG AGATGTCAGG GAACCACTTC CCTGAGATCA GGCCTGGCTC CTTCCATGGC 
CTGAGCTCCC TCAAGAAGCT CTGGGTCATG AACTCACAGG TCAGCCTGAT TGAGCGGAAT 
GCTTTTGACG GGCTGGCTTC ACTTGTGGAA CTCAACTTGG CCCACAATAA CCTCTCTTCT 
TTGCCCCATG ACCTCTTTAC CCCGCTGAGG TACCTGGTGG AGTTGCATCT ACACCACAAC 
CCTTGGAACT GTGATTGTGA CATTCTGTGG CTAGCCTGGT GGCTTCGAGA GTATATACCC 
ACCAATTCCA CCTGCTGTGG CCGCTGTCAT GCTCCCATGC ACATGCGAGG CCGCTACCTC 
GTGGAGGTGG ACCAGGCCTC CTTCCAGTGC TCTGCCCCCT TCATCATGGA CGCACCTCGA 
GACCTCAACA TTTCTGAGGG TCGGATGGCA GAACTTAAGT GTCGGACTCC CCCTATGTCC 
TCCGTGAAGT GGTTGCTGCC CAATGGGACA GTGCTCAGCC ACGCCTCCCG CCACCCAAGG 
ATCTCTGTCC TCAACGACGG CACCTTGAAC TTTTCCCACG TGCTGCTTTC AGACACTGGG 
GTGTACACAT GCATGGTGAC CAATGTTGCA GGCAACTCCA ACGCCTCGGC CTACCTCAAT 
GTGAGCACGG CTGAGCTTAA CACCTCCAAC TACAGCTTCT TCACCACAGT AACAGTGGAG 
ACCACGGAGA TCTCGCCTGA GGACACAACG CGAAAGTACA AGCCTGTTCC TACCACGTCC 
ACTGGTTACC AGCCGGCATA TACCACCTCT ACCACGGTGC TCATTCAGAC TACCCGTGTG 
CCCAAGCAGG TGGCAGTACC CGCGACAGAC ACCACTGACA AGATGCAGAC CAGCCTGGAT 
GAAGTCATGA AGACCACCAA GATCATCATT GGCTGCTTTG TGGCAGTGAC TCTGCTAGCT 
GCCGCCATGT TGATTGTCTT CTATAAACTT CGTAAGCGGC ACCAGCAGCG GAGTACAGTC 
ACAGCCGCCC GGACTGTTGA GATAATCCAG GTGGACGAAG ACATCCCAGC AGCAACATCC 
GCAGCAGCAA CAGCAGCTCC GTCCGGTGTA TCAGGTGAGG GGGCAGTAGT GCTGCCCACA 
ATTCATGACC ATATTAACTA CAACACCTAC AAACCAGCAC ATGGGGCCCA CTGGACAGAA 
AACAGCCTGG GGAACTCTCT GCACCCCACA GTCACCACTA TCTCTGAACC TTATATAATT 
CAGACCCATA CCAAGGACAA GGTACAGGAA ACTCAAATAT GA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_071426.1
CDS	138..2099
Translation	MKLLWQVTVHHHTWNAILLPFVYLTAQVWILCAAIAAAASAGPQNCPSVCSCSNQFSKVVCTRRGLSEVPQGIPSNTRYLNLMENNIQMIQADTFRHLHHLEVLQLGRNSIRQIEVGAFNGLASLNTLELFDNWLTVIPSGAFEYLSKLRELWLRNNPIESIPSYAFNRVPSLMRLDLGELKKLEYISEGAFEGLFNLKYLNLGMCNIKDMPNLTPLVGLEELEMSGNHFPEIRPGSFHGLSSLKKLWVMNSQVSLIERNAFDGLASLVELNLAHNNLSSLPHDLFTPLRYLVELHLHHNPWNCDCDILWLAWWLREYIPTNSTCCGRCHAPMHMRGRYLVEVDQASFQCSAPFIMDAPRDLNISEGRMAELKCRTPPMSSVKWLLPNGTVLSHASRHPRISVLNDGTLNFSHVLLSDTGVYTCMVTNVAGNSNASAYLNVSTAELNTSNYSFFTTVTVETTEISPEDTTRKYKPVPTTSTGYQPAYTTSTTVLIQTTRVPKQVAVPATDTTDKMQTSLDEVMKTTKIIIGCFVAVTLLAAAMLIVFYKLRKRHQQRSTVTAARTVEIIQVDEDIPAATSAAATAAPSGVSGEGAVVLPTIHDHINYNTYKPAHGAHWTENSLGNSLHPTVTTISEPYIIQTHTKDKVQETQI

Target ORF information:

RefSeq Version	NM_022143.4
Organism	Homo sapiens(human)
Definition	Homo sapiens leucine rich repeat containing 4 (LRRC4), mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_022143.4

ORF Insert Sequence:

ATGAAGCTCT TGTGGCAGGT AACTGTGCAC CACCACACCT GGAATGCCAT CCTGCTCCCG 
TTCGTCTACC TCACGGCGCA AGTGTGGATT CTGTGTGCAG CCATCGCTGC TGCCGCCTCA 
GCCGGGCCCC AGAACTGCCC CTCCGTCTGC TCGTGCAGTA ACCAGTTCAG CAAGGTGGTG 
TGCACGCGCC GGGGCCTCTC CGAGGTCCCG CAGGGTATTC CCTCGAACAC CCGGTACCTC 
AACCTCATGG AGAACAACAT CCAGATGATC CAGGCCGACA CCTTCCGCCA CCTCCACCAC 
CTGGAGGTCC TGCAGTTGGG CAGGAACTCC ATCCGGCAGA TTGAGGTGGG GGCCTTCAAC 
GGCCTGGCCA GCCTCAACAC CCTGGAGCTG TTCGACAACT GGCTGACAGT CATCCCTAGC 
GGGGCCTTTG AATACCTGTC CAAGCTGCGG GAGCTCTGGC TTCGCAACAA CCCCATCGAA 
AGCATCCCCT CTTACGCCTT CAACCGGGTG CCCTCCCTCA TGCGCCTGGA CTTGGGGGAG 
CTCAAGAAGC TGGAGTATAT CTCTGAGGGA GCTTTTGAGG GGCTGTTCAA CCTCAAGTAT 
CTGAACTTGG GCATGTGCAA CATTAAAGAC ATGCCCAATC TCACCCCCCT GGTGGGGCTG 
GAGGAGCTGG AGATGTCAGG GAACCACTTC CCTGAGATCA GGCCTGGCTC CTTCCATGGC 
CTGAGCTCCC TCAAGAAGCT CTGGGTCATG AACTCACAGG TCAGCCTGAT TGAGCGGAAT 
GCTTTTGACG GGCTGGCTTC ACTTGTGGAA CTCAACTTGG CCCACAATAA CCTCTCTTCT 
TTGCCCCATG ACCTCTTTAC CCCGCTGAGG TACCTGGTGG AGTTGCATCT ACACCACAAC 
CCTTGGAACT GTGATTGTGA CATTCTGTGG CTAGCCTGGT GGCTTCGAGA GTATATACCC 
ACCAATTCCA CCTGCTGTGG CCGCTGTCAT GCTCCCATGC ACATGCGAGG CCGCTACCTC 
GTGGAGGTGG ACCAGGCCTC CTTCCAGTGC TCTGCCCCCT TCATCATGGA CGCACCTCGA 
GACCTCAACA TTTCTGAGGG TCGGATGGCA GAACTTAAGT GTCGGACTCC CCCTATGTCC 
TCCGTGAAGT GGTTGCTGCC CAATGGGACA GTGCTCAGCC ACGCCTCCCG CCACCCAAGG 
ATCTCTGTCC TCAACGACGG CACCTTGAAC TTTTCCCACG TGCTGCTTTC AGACACTGGG 
GTGTACACAT GCATGGTGAC CAATGTTGCA GGCAACTCCA ACGCCTCGGC CTACCTCAAT 
GTGAGCACGG CTGAGCTTAA CACCTCCAAC TACAGCTTCT TCACCACAGT AACAGTGGAG 
ACCACGGAGA TCTCGCCTGA GGACACAACG CGAAAGTACA AGCCTGTTCC TACCACGTCC 
ACTGGTTACC AGCCGGCATA TACCACCTCT ACCACGGTGC TCATTCAGAC TACCCGTGTG 
CCCAAGCAGG TGGCAGTACC CGCGACAGAC ACCACTGACA AGATGCAGAC CAGCCTGGAT 
GAAGTCATGA AGACCACCAA GATCATCATT GGCTGCTTTG TGGCAGTGAC TCTGCTAGCT 
GCCGCCATGT TGATTGTCTT CTATAAACTT CGTAAGCGGC ACCAGCAGCG GAGTACAGTC 
ACAGCCGCCC GGACTGTTGA GATAATCCAG GTGGACGAAG ACATCCCAGC AGCAACATCC 
GCAGCAGCAA CAGCAGCTCC GTCCGGTGTA TCAGGTGAGG GGGCAGTAGT GCTGCCCACA 
ATTCATGACC ATATTAACTA CAACACCTAC AAACCAGCAC ATGGGGCCCA CTGGACAGAA 
AACAGCCTGG GGAACTCTCT GCACCCCACA GTCACCACTA TCTCTGAACC TTATATAATT 
CAGACCCATA CCAAGGACAA GGTACAGGAA ACTCAAATAT GA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

LRRC4 ( NM_022143.5 ) cDNA ORF clone, Homo sapiens(human) -> NP_071426.1 Homo sapiens leucine rich repeat containing 4 (LRRC4), mRNA.

Price & Availability↑

CloneID	OHu30186
Clone ID Related Accession (Same CDS sequence)	NM_022143.4 , XM_017012505.1 , XM_011516461.3 , XM_011516461.2 , XM_011516461.1 , NM_022143.5
Accession Version	NM_022143.5 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 1962bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-11-16
Organism	Homo sapiens(human)
Product	leucine-rich repeat-containing protein 4 precursor
Comment	Comment: VALIDATED REFSEQ: This record has undergone validation or preliminary review. The reference sequence was derived from AC008039.1, AF196976.4, BC111745.1 and BU682120.1. On Nov 22, 2018 this sequence version replaced NM_022143.4. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: AF196976.4, BC111561.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA1965299, SAMEA1966682 [ECO:0000348] ##Evidence-Data-END## ##RefSeq-Attributes-START## MANE Ensembl match :: ENST00000249363.4/ ENSP00000249363.3 RefSeq Select criteria :: based on conservation, expression, longest protein ##RefSeq-Attributes-END## COMPLETENESS: full length.

ATGAAGCTCT TGTGGCAGGT AACTGTGCAC CACCACACCT GGAATGCCAT CCTGCTCCCG 
TTCGTCTACC TCACGGCGCA AGTGTGGATT CTGTGTGCAG CCATCGCTGC TGCCGCCTCA 
GCCGGGCCCC AGAACTGCCC CTCCGTCTGC TCGTGCAGTA ACCAGTTCAG CAAGGTGGTG 
TGCACGCGCC GGGGCCTCTC CGAGGTCCCG CAGGGTATTC CCTCGAACAC CCGGTACCTC 
AACCTCATGG AGAACAACAT CCAGATGATC CAGGCCGACA CCTTCCGCCA CCTCCACCAC 
CTGGAGGTCC TGCAGTTGGG CAGGAACTCC ATCCGGCAGA TTGAGGTGGG GGCCTTCAAC 
GGCCTGGCCA GCCTCAACAC CCTGGAGCTG TTCGACAACT GGCTGACAGT CATCCCTAGC 
GGGGCCTTTG AATACCTGTC CAAGCTGCGG GAGCTCTGGC TTCGCAACAA CCCCATCGAA 
AGCATCCCCT CTTACGCCTT CAACCGGGTG CCCTCCCTCA TGCGCCTGGA CTTGGGGGAG 
CTCAAGAAGC TGGAGTATAT CTCTGAGGGA GCTTTTGAGG GGCTGTTCAA CCTCAAGTAT 
CTGAACTTGG GCATGTGCAA CATTAAAGAC ATGCCCAATC TCACCCCCCT GGTGGGGCTG 
GAGGAGCTGG AGATGTCAGG GAACCACTTC CCTGAGATCA GGCCTGGCTC CTTCCATGGC 
CTGAGCTCCC TCAAGAAGCT CTGGGTCATG AACTCACAGG TCAGCCTGAT TGAGCGGAAT 
GCTTTTGACG GGCTGGCTTC ACTTGTGGAA CTCAACTTGG CCCACAATAA CCTCTCTTCT 
TTGCCCCATG ACCTCTTTAC CCCGCTGAGG TACCTGGTGG AGTTGCATCT ACACCACAAC 
CCTTGGAACT GTGATTGTGA CATTCTGTGG CTAGCCTGGT GGCTTCGAGA GTATATACCC 
ACCAATTCCA CCTGCTGTGG CCGCTGTCAT GCTCCCATGC ACATGCGAGG CCGCTACCTC 
GTGGAGGTGG ACCAGGCCTC CTTCCAGTGC TCTGCCCCCT TCATCATGGA CGCACCTCGA 
GACCTCAACA TTTCTGAGGG TCGGATGGCA GAACTTAAGT GTCGGACTCC CCCTATGTCC 
TCCGTGAAGT GGTTGCTGCC CAATGGGACA GTGCTCAGCC ACGCCTCCCG CCACCCAAGG 
ATCTCTGTCC TCAACGACGG CACCTTGAAC TTTTCCCACG TGCTGCTTTC AGACACTGGG 
GTGTACACAT GCATGGTGAC CAATGTTGCA GGCAACTCCA ACGCCTCGGC CTACCTCAAT 
GTGAGCACGG CTGAGCTTAA CACCTCCAAC TACAGCTTCT TCACCACAGT AACAGTGGAG 
ACCACGGAGA TCTCGCCTGA GGACACAACG CGAAAGTACA AGCCTGTTCC TACCACGTCC 
ACTGGTTACC AGCCGGCATA TACCACCTCT ACCACGGTGC TCATTCAGAC TACCCGTGTG 
CCCAAGCAGG TGGCAGTACC CGCGACAGAC ACCACTGACA AGATGCAGAC CAGCCTGGAT 
GAAGTCATGA AGACCACCAA GATCATCATT GGCTGCTTTG TGGCAGTGAC TCTGCTAGCT 
GCCGCCATGT TGATTGTCTT CTATAAACTT CGTAAGCGGC ACCAGCAGCG GAGTACAGTC 
ACAGCCGCCC GGACTGTTGA GATAATCCAG GTGGACGAAG ACATCCCAGC AGCAACATCC 
GCAGCAGCAA CAGCAGCTCC GTCCGGTGTA TCAGGTGAGG GGGCAGTAGT GCTGCCCACA 
ATTCATGACC ATATTAACTA CAACACCTAC AAACCAGCAC ATGGGGCCCA CTGGACAGAA 
AACAGCCTGG GGAACTCTCT GCACCCCACA GTCACCACTA TCTCTGAACC TTATATAATT 
CAGACCCATA CCAAGGACAA GGTACAGGAA ACTCAAATAT GA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_071426.1
CDS	626..2587
Translation	MKLLWQVTVHHHTWNAILLPFVYLTAQVWILCAAIAAAASAGPQNCPSVCSCSNQFSKVVCTRRGLSEVPQGIPSNTRYLNLMENNIQMIQADTFRHLHHLEVLQLGRNSIRQIEVGAFNGLASLNTLELFDNWLTVIPSGAFEYLSKLRELWLRNNPIESIPSYAFNRVPSLMRLDLGELKKLEYISEGAFEGLFNLKYLNLGMCNIKDMPNLTPLVGLEELEMSGNHFPEIRPGSFHGLSSLKKLWVMNSQVSLIERNAFDGLASLVELNLAHNNLSSLPHDLFTPLRYLVELHLHHNPWNCDCDILWLAWWLREYIPTNSTCCGRCHAPMHMRGRYLVEVDQASFQCSAPFIMDAPRDLNISEGRMAELKCRTPPMSSVKWLLPNGTVLSHASRHPRISVLNDGTLNFSHVLLSDTGVYTCMVTNVAGNSNASAYLNVSTAELNTSNYSFFTTVTVETTEISPEDTTRKYKPVPTTSTGYQPAYTTSTTVLIQTTRVPKQVAVPATDTTDKMQTSLDEVMKTTKIIIGCFVAVTLLAAAMLIVFYKLRKRHQQRSTVTAARTVEIIQVDEDIPAATSAAATAAPSGVSGEGAVVLPTIHDHINYNTYKPAHGAHWTENSLGNSLHPTVTTISEPYIIQTHTKDKVQETQI

Target ORF information:

RefSeq Version	NM_022143.5
Organism	Homo sapiens(human)
Definition	Homo sapiens leucine rich repeat containing 4 (LRRC4), mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_022143.5

ORF Insert Sequence:

ATGAAGCTCT TGTGGCAGGT AACTGTGCAC CACCACACCT GGAATGCCAT CCTGCTCCCG 
TTCGTCTACC TCACGGCGCA AGTGTGGATT CTGTGTGCAG CCATCGCTGC TGCCGCCTCA 
GCCGGGCCCC AGAACTGCCC CTCCGTCTGC TCGTGCAGTA ACCAGTTCAG CAAGGTGGTG 
TGCACGCGCC GGGGCCTCTC CGAGGTCCCG CAGGGTATTC CCTCGAACAC CCGGTACCTC 
AACCTCATGG AGAACAACAT CCAGATGATC CAGGCCGACA CCTTCCGCCA CCTCCACCAC 
CTGGAGGTCC TGCAGTTGGG CAGGAACTCC ATCCGGCAGA TTGAGGTGGG GGCCTTCAAC 
GGCCTGGCCA GCCTCAACAC CCTGGAGCTG TTCGACAACT GGCTGACAGT CATCCCTAGC 
GGGGCCTTTG AATACCTGTC CAAGCTGCGG GAGCTCTGGC TTCGCAACAA CCCCATCGAA 
AGCATCCCCT CTTACGCCTT CAACCGGGTG CCCTCCCTCA TGCGCCTGGA CTTGGGGGAG 
CTCAAGAAGC TGGAGTATAT CTCTGAGGGA GCTTTTGAGG GGCTGTTCAA CCTCAAGTAT 
CTGAACTTGG GCATGTGCAA CATTAAAGAC ATGCCCAATC TCACCCCCCT GGTGGGGCTG 
GAGGAGCTGG AGATGTCAGG GAACCACTTC CCTGAGATCA GGCCTGGCTC CTTCCATGGC 
CTGAGCTCCC TCAAGAAGCT CTGGGTCATG AACTCACAGG TCAGCCTGAT TGAGCGGAAT 
GCTTTTGACG GGCTGGCTTC ACTTGTGGAA CTCAACTTGG CCCACAATAA CCTCTCTTCT 
TTGCCCCATG ACCTCTTTAC CCCGCTGAGG TACCTGGTGG AGTTGCATCT ACACCACAAC 
CCTTGGAACT GTGATTGTGA CATTCTGTGG CTAGCCTGGT GGCTTCGAGA GTATATACCC 
ACCAATTCCA CCTGCTGTGG CCGCTGTCAT GCTCCCATGC ACATGCGAGG CCGCTACCTC 
GTGGAGGTGG ACCAGGCCTC CTTCCAGTGC TCTGCCCCCT TCATCATGGA CGCACCTCGA 
GACCTCAACA TTTCTGAGGG TCGGATGGCA GAACTTAAGT GTCGGACTCC CCCTATGTCC 
TCCGTGAAGT GGTTGCTGCC CAATGGGACA GTGCTCAGCC ACGCCTCCCG CCACCCAAGG 
ATCTCTGTCC TCAACGACGG CACCTTGAAC TTTTCCCACG TGCTGCTTTC AGACACTGGG 
GTGTACACAT GCATGGTGAC CAATGTTGCA GGCAACTCCA ACGCCTCGGC CTACCTCAAT 
GTGAGCACGG CTGAGCTTAA CACCTCCAAC TACAGCTTCT TCACCACAGT AACAGTGGAG 
ACCACGGAGA TCTCGCCTGA GGACACAACG CGAAAGTACA AGCCTGTTCC TACCACGTCC 
ACTGGTTACC AGCCGGCATA TACCACCTCT ACCACGGTGC TCATTCAGAC TACCCGTGTG 
CCCAAGCAGG TGGCAGTACC CGCGACAGAC ACCACTGACA AGATGCAGAC CAGCCTGGAT 
GAAGTCATGA AGACCACCAA GATCATCATT GGCTGCTTTG TGGCAGTGAC TCTGCTAGCT 
GCCGCCATGT TGATTGTCTT CTATAAACTT CGTAAGCGGC ACCAGCAGCG GAGTACAGTC 
ACAGCCGCCC GGACTGTTGA GATAATCCAG GTGGACGAAG ACATCCCAGC AGCAACATCC 
GCAGCAGCAA CAGCAGCTCC GTCCGGTGTA TCAGGTGAGG GGGCAGTAGT GCTGCCCACA 
ATTCATGACC ATATTAACTA CAACACCTAC AAACCAGCAC ATGGGGCCCA CTGGACAGAA 
AACAGCCTGG GGAACTCTCT GCACCCCACA GTCACCACTA TCTCTGAACC TTATATAATT 
CAGACCCATA CCAAGGACAA GGTACAGGAA ACTCAAATAT GA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

LRRC4 ( XM_017012505.1 ) cDNA ORF clone, Homo sapiens(human) -> XP_016867994.1 Homo sapiens leucine rich repeat containing 4 (LRRC4), transcript variant X1, mRNA.

Price & Availability↑

CloneID	OHu30186
Clone ID Related Accession (Same CDS sequence)	NM_022143.4 , XM_017012505.1 , XM_011516461.3 , XM_011516461.2 , XM_011516461.1 , NM_022143.5
Accession Version	XM_017012505.1 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 1962bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2016-06-05
Organism	Homo sapiens(human)
Product	leucine-rich repeat-containing protein 4 isoform X1
Comment	Comment: MODEL REFSEQ: This record is predicted by automated computational analysis. This record is derived from a genomic sequence (NC_000007.14) annotated using gene prediction method: Gnomon, supported by mRNA and EST evidence. Also see: Documentation of NCBI's Annotation Process ##Genome-Annotation-Data-START## Annotation Provider :: NCBI Annotation Status :: Full annotation Annotation Version :: Homo sapiens Annotation Release 108 Annotation Pipeline :: NCBI eukaryotic genome annotation pipeline Annotation Software Version :: 7.0 Annotation Method :: Best-placed RefSeq; Gnomon Features Annotated :: Gene; mRNA; CDS; ncRNA ##Genome-Annotation-Data-END##

ATGAAGCTCT TGTGGCAGGT AACTGTGCAC CACCACACCT GGAATGCCAT CCTGCTCCCG 
TTCGTCTACC TCACGGCGCA AGTGTGGATT CTGTGTGCAG CCATCGCTGC TGCCGCCTCA 
GCCGGGCCCC AGAACTGCCC CTCCGTCTGC TCGTGCAGTA ACCAGTTCAG CAAGGTGGTG 
TGCACGCGCC GGGGCCTCTC CGAGGTCCCG CAGGGTATTC CCTCGAACAC CCGGTACCTC 
AACCTCATGG AGAACAACAT CCAGATGATC CAGGCCGACA CCTTCCGCCA CCTCCACCAC 
CTGGAGGTCC TGCAGTTGGG CAGGAACTCC ATCCGGCAGA TTGAGGTGGG GGCCTTCAAC 
GGCCTGGCCA GCCTCAACAC CCTGGAGCTG TTCGACAACT GGCTGACAGT CATCCCTAGC 
GGGGCCTTTG AATACCTGTC CAAGCTGCGG GAGCTCTGGC TTCGCAACAA CCCCATCGAA 
AGCATCCCCT CTTACGCCTT CAACCGGGTG CCCTCCCTCA TGCGCCTGGA CTTGGGGGAG 
CTCAAGAAGC TGGAGTATAT CTCTGAGGGA GCTTTTGAGG GGCTGTTCAA CCTCAAGTAT 
CTGAACTTGG GCATGTGCAA CATTAAAGAC ATGCCCAATC TCACCCCCCT GGTGGGGCTG 
GAGGAGCTGG AGATGTCAGG GAACCACTTC CCTGAGATCA GGCCTGGCTC CTTCCATGGC 
CTGAGCTCCC TCAAGAAGCT CTGGGTCATG AACTCACAGG TCAGCCTGAT TGAGCGGAAT 
GCTTTTGACG GGCTGGCTTC ACTTGTGGAA CTCAACTTGG CCCACAATAA CCTCTCTTCT 
TTGCCCCATG ACCTCTTTAC CCCGCTGAGG TACCTGGTGG AGTTGCATCT ACACCACAAC 
CCTTGGAACT GTGATTGTGA CATTCTGTGG CTAGCCTGGT GGCTTCGAGA GTATATACCC 
ACCAATTCCA CCTGCTGTGG CCGCTGTCAT GCTCCCATGC ACATGCGAGG CCGCTACCTC 
GTGGAGGTGG ACCAGGCCTC CTTCCAGTGC TCTGCCCCCT TCATCATGGA CGCACCTCGA 
GACCTCAACA TTTCTGAGGG TCGGATGGCA GAACTTAAGT GTCGGACTCC CCCTATGTCC 
TCCGTGAAGT GGTTGCTGCC CAATGGGACA GTGCTCAGCC ACGCCTCCCG CCACCCAAGG 
ATCTCTGTCC TCAACGACGG CACCTTGAAC TTTTCCCACG TGCTGCTTTC AGACACTGGG 
GTGTACACAT GCATGGTGAC CAATGTTGCA GGCAACTCCA ACGCCTCGGC CTACCTCAAT 
GTGAGCACGG CTGAGCTTAA CACCTCCAAC TACAGCTTCT TCACCACAGT AACAGTGGAG 
ACCACGGAGA TCTCGCCTGA GGACACAACG CGAAAGTACA AGCCTGTTCC TACCACGTCC 
ACTGGTTACC AGCCGGCATA TACCACCTCT ACCACGGTGC TCATTCAGAC TACCCGTGTG 
CCCAAGCAGG TGGCAGTACC CGCGACAGAC ACCACTGACA AGATGCAGAC CAGCCTGGAT 
GAAGTCATGA AGACCACCAA GATCATCATT GGCTGCTTTG TGGCAGTGAC TCTGCTAGCT 
GCCGCCATGT TGATTGTCTT CTATAAACTT CGTAAGCGGC ACCAGCAGCG GAGTACAGTC 
ACAGCCGCCC GGACTGTTGA GATAATCCAG GTGGACGAAG ACATCCCAGC AGCAACATCC 
GCAGCAGCAA CAGCAGCTCC GTCCGGTGTA TCAGGTGAGG GGGCAGTAGT GCTGCCCACA 
ATTCATGACC ATATTAACTA CAACACCTAC AAACCAGCAC ATGGGGCCCA CTGGACAGAA 
AACAGCCTGG GGAACTCTCT GCACCCCACA GTCACCACTA TCTCTGAACC TTATATAATT 
CAGACCCATA CCAAGGACAA GGTACAGGAA ACTCAAATAT GA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	XP_016867994.1
CDS	334..2295
Translation	MKLLWQVTVHHHTWNAILLPFVYLTAQVWILCAAIAAAASAGPQNCPSVCSCSNQFSKVVCTRRGLSEVPQGIPSNTRYLNLMENNIQMIQADTFRHLHHLEVLQLGRNSIRQIEVGAFNGLASLNTLELFDNWLTVIPSGAFEYLSKLRELWLRNNPIESIPSYAFNRVPSLMRLDLGELKKLEYISEGAFEGLFNLKYLNLGMCNIKDMPNLTPLVGLEELEMSGNHFPEIRPGSFHGLSSLKKLWVMNSQVSLIERNAFDGLASLVELNLAHNNLSSLPHDLFTPLRYLVELHLHHNPWNCDCDILWLAWWLREYIPTNSTCCGRCHAPMHMRGRYLVEVDQASFQCSAPFIMDAPRDLNISEGRMAELKCRTPPMSSVKWLLPNGTVLSHASRHPRISVLNDGTLNFSHVLLSDTGVYTCMVTNVAGNSNASAYLNVSTAELNTSNYSFFTTVTVETTEISPEDTTRKYKPVPTTSTGYQPAYTTSTTVLIQTTRVPKQVAVPATDTTDKMQTSLDEVMKTTKIIIGCFVAVTLLAAAMLIVFYKLRKRHQQRSTVTAARTVEIIQVDEDIPAATSAAATAAPSGVSGEGAVVLPTIHDHINYNTYKPAHGAHWTENSLGNSLHPTVTTISEPYIIQTHTKDKVQETQI

Target ORF information:

RefSeq Version	XM_017012505.1
Organism	Homo sapiens(human)
Definition	Homo sapiens leucine rich repeat containing 4 (LRRC4), transcript variant X1, mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

XM_017012505.1

ORF Insert Sequence:

ATGAAGCTCT TGTGGCAGGT AACTGTGCAC CACCACACCT GGAATGCCAT CCTGCTCCCG 
TTCGTCTACC TCACGGCGCA AGTGTGGATT CTGTGTGCAG CCATCGCTGC TGCCGCCTCA 
GCCGGGCCCC AGAACTGCCC CTCCGTCTGC TCGTGCAGTA ACCAGTTCAG CAAGGTGGTG 
TGCACGCGCC GGGGCCTCTC CGAGGTCCCG CAGGGTATTC CCTCGAACAC CCGGTACCTC 
AACCTCATGG AGAACAACAT CCAGATGATC CAGGCCGACA CCTTCCGCCA CCTCCACCAC 
CTGGAGGTCC TGCAGTTGGG CAGGAACTCC ATCCGGCAGA TTGAGGTGGG GGCCTTCAAC 
GGCCTGGCCA GCCTCAACAC CCTGGAGCTG TTCGACAACT GGCTGACAGT CATCCCTAGC 
GGGGCCTTTG AATACCTGTC CAAGCTGCGG GAGCTCTGGC TTCGCAACAA CCCCATCGAA 
AGCATCCCCT CTTACGCCTT CAACCGGGTG CCCTCCCTCA TGCGCCTGGA CTTGGGGGAG 
CTCAAGAAGC TGGAGTATAT CTCTGAGGGA GCTTTTGAGG GGCTGTTCAA CCTCAAGTAT 
CTGAACTTGG GCATGTGCAA CATTAAAGAC ATGCCCAATC TCACCCCCCT GGTGGGGCTG 
GAGGAGCTGG AGATGTCAGG GAACCACTTC CCTGAGATCA GGCCTGGCTC CTTCCATGGC 
CTGAGCTCCC TCAAGAAGCT CTGGGTCATG AACTCACAGG TCAGCCTGAT TGAGCGGAAT 
GCTTTTGACG GGCTGGCTTC ACTTGTGGAA CTCAACTTGG CCCACAATAA CCTCTCTTCT 
TTGCCCCATG ACCTCTTTAC CCCGCTGAGG TACCTGGTGG AGTTGCATCT ACACCACAAC 
CCTTGGAACT GTGATTGTGA CATTCTGTGG CTAGCCTGGT GGCTTCGAGA GTATATACCC 
ACCAATTCCA CCTGCTGTGG CCGCTGTCAT GCTCCCATGC ACATGCGAGG CCGCTACCTC 
GTGGAGGTGG ACCAGGCCTC CTTCCAGTGC TCTGCCCCCT TCATCATGGA CGCACCTCGA 
GACCTCAACA TTTCTGAGGG TCGGATGGCA GAACTTAAGT GTCGGACTCC CCCTATGTCC 
TCCGTGAAGT GGTTGCTGCC CAATGGGACA GTGCTCAGCC ACGCCTCCCG CCACCCAAGG 
ATCTCTGTCC TCAACGACGG CACCTTGAAC TTTTCCCACG TGCTGCTTTC AGACACTGGG 
GTGTACACAT GCATGGTGAC CAATGTTGCA GGCAACTCCA ACGCCTCGGC CTACCTCAAT 
GTGAGCACGG CTGAGCTTAA CACCTCCAAC TACAGCTTCT TCACCACAGT AACAGTGGAG 
ACCACGGAGA TCTCGCCTGA GGACACAACG CGAAAGTACA AGCCTGTTCC TACCACGTCC 
ACTGGTTACC AGCCGGCATA TACCACCTCT ACCACGGTGC TCATTCAGAC TACCCGTGTG 
CCCAAGCAGG TGGCAGTACC CGCGACAGAC ACCACTGACA AGATGCAGAC CAGCCTGGAT 
GAAGTCATGA AGACCACCAA GATCATCATT GGCTGCTTTG TGGCAGTGAC TCTGCTAGCT 
GCCGCCATGT TGATTGTCTT CTATAAACTT CGTAAGCGGC ACCAGCAGCG GAGTACAGTC 
ACAGCCGCCC GGACTGTTGA GATAATCCAG GTGGACGAAG ACATCCCAGC AGCAACATCC 
GCAGCAGCAA CAGCAGCTCC GTCCGGTGTA TCAGGTGAGG GGGCAGTAGT GCTGCCCACA 
ATTCATGACC ATATTAACTA CAACACCTAC AAACCAGCAC ATGGGGCCCA CTGGACAGAA 
AACAGCCTGG GGAACTCTCT GCACCCCACA GTCACCACTA TCTCTGAACC TTATATAATT 
CAGACCCATA CCAAGGACAA GGTACAGGAA ACTCAAATAT GA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

LRRC4 ( XM_011516461.3 ) cDNA ORF clone, Homo sapiens(human) -> XP_011514763.1 Homo sapiens leucine rich repeat containing 4 (LRRC4), transcript variant X1, mRNA.

Price & Availability↑

CloneID	OHu30186
Clone ID Related Accession (Same CDS sequence)	NM_022143.4 , XM_017012505.1 , XM_011516461.3 , XM_011516461.2 , XM_011516461.1 , NM_022143.5
Accession Version	XM_011516461.3 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 1962bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-12-05
Organism	Homo sapiens(human)
Product	leucine-rich repeat-containing protein 4 isoform X1
Comment	Comment: MODEL REFSEQ: This record is predicted by automated computational analysis. This record is derived from a genomic sequence (NC_000007.14) annotated using gene prediction method: Gnomon, supported by mRNA and EST evidence. Also see: Documentation of NCBI's Annotation Process On Mar 26, 2018 this sequence version replaced XM_011516461.2. ##Genome-Annotation-Data-START## Annotation Provider :: NCBI Annotation Status :: Updated annotation Annotation Name :: Homo sapiens Updated Annotation Release 109.20191205 Annotation Version :: 109.20191205 Annotation Pipeline :: NCBI eukaryotic genome annotation pipeline Annotation Software Version :: 8.3 Annotation Method :: Best-placed RefSeq; propagated RefSeq model Features Annotated :: Gene; mRNA; CDS; ncRNA ##Genome-Annotation-Data-END##

ATGAAGCTCT TGTGGCAGGT AACTGTGCAC CACCACACCT GGAATGCCAT CCTGCTCCCG 
TTCGTCTACC TCACGGCGCA AGTGTGGATT CTGTGTGCAG CCATCGCTGC TGCCGCCTCA 
GCCGGGCCCC AGAACTGCCC CTCCGTCTGC TCGTGCAGTA ACCAGTTCAG CAAGGTGGTG 
TGCACGCGCC GGGGCCTCTC CGAGGTCCCG CAGGGTATTC CCTCGAACAC CCGGTACCTC 
AACCTCATGG AGAACAACAT CCAGATGATC CAGGCCGACA CCTTCCGCCA CCTCCACCAC 
CTGGAGGTCC TGCAGTTGGG CAGGAACTCC ATCCGGCAGA TTGAGGTGGG GGCCTTCAAC 
GGCCTGGCCA GCCTCAACAC CCTGGAGCTG TTCGACAACT GGCTGACAGT CATCCCTAGC 
GGGGCCTTTG AATACCTGTC CAAGCTGCGG GAGCTCTGGC TTCGCAACAA CCCCATCGAA 
AGCATCCCCT CTTACGCCTT CAACCGGGTG CCCTCCCTCA TGCGCCTGGA CTTGGGGGAG 
CTCAAGAAGC TGGAGTATAT CTCTGAGGGA GCTTTTGAGG GGCTGTTCAA CCTCAAGTAT 
CTGAACTTGG GCATGTGCAA CATTAAAGAC ATGCCCAATC TCACCCCCCT GGTGGGGCTG 
GAGGAGCTGG AGATGTCAGG GAACCACTTC CCTGAGATCA GGCCTGGCTC CTTCCATGGC 
CTGAGCTCCC TCAAGAAGCT CTGGGTCATG AACTCACAGG TCAGCCTGAT TGAGCGGAAT 
GCTTTTGACG GGCTGGCTTC ACTTGTGGAA CTCAACTTGG CCCACAATAA CCTCTCTTCT 
TTGCCCCATG ACCTCTTTAC CCCGCTGAGG TACCTGGTGG AGTTGCATCT ACACCACAAC 
CCTTGGAACT GTGATTGTGA CATTCTGTGG CTAGCCTGGT GGCTTCGAGA GTATATACCC 
ACCAATTCCA CCTGCTGTGG CCGCTGTCAT GCTCCCATGC ACATGCGAGG CCGCTACCTC 
GTGGAGGTGG ACCAGGCCTC CTTCCAGTGC TCTGCCCCCT TCATCATGGA CGCACCTCGA 
GACCTCAACA TTTCTGAGGG TCGGATGGCA GAACTTAAGT GTCGGACTCC CCCTATGTCC 
TCCGTGAAGT GGTTGCTGCC CAATGGGACA GTGCTCAGCC ACGCCTCCCG CCACCCAAGG 
ATCTCTGTCC TCAACGACGG CACCTTGAAC TTTTCCCACG TGCTGCTTTC AGACACTGGG 
GTGTACACAT GCATGGTGAC CAATGTTGCA GGCAACTCCA ACGCCTCGGC CTACCTCAAT 
GTGAGCACGG CTGAGCTTAA CACCTCCAAC TACAGCTTCT TCACCACAGT AACAGTGGAG 
ACCACGGAGA TCTCGCCTGA GGACACAACG CGAAAGTACA AGCCTGTTCC TACCACGTCC 
ACTGGTTACC AGCCGGCATA TACCACCTCT ACCACGGTGC TCATTCAGAC TACCCGTGTG 
CCCAAGCAGG TGGCAGTACC CGCGACAGAC ACCACTGACA AGATGCAGAC CAGCCTGGAT 
GAAGTCATGA AGACCACCAA GATCATCATT GGCTGCTTTG TGGCAGTGAC TCTGCTAGCT 
GCCGCCATGT TGATTGTCTT CTATAAACTT CGTAAGCGGC ACCAGCAGCG GAGTACAGTC 
ACAGCCGCCC GGACTGTTGA GATAATCCAG GTGGACGAAG ACATCCCAGC AGCAACATCC 
GCAGCAGCAA CAGCAGCTCC GTCCGGTGTA TCAGGTGAGG GGGCAGTAGT GCTGCCCACA 
ATTCATGACC ATATTAACTA CAACACCTAC AAACCAGCAC ATGGGGCCCA CTGGACAGAA 
AACAGCCTGG GGAACTCTCT GCACCCCACA GTCACCACTA TCTCTGAACC TTATATAATT 
CAGACCCATA CCAAGGACAA GGTACAGGAA ACTCAAATAT GA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	XP_011514763.1
CDS	278..2239
Translation	MKLLWQVTVHHHTWNAILLPFVYLTAQVWILCAAIAAAASAGPQNCPSVCSCSNQFSKVVCTRRGLSEVPQGIPSNTRYLNLMENNIQMIQADTFRHLHHLEVLQLGRNSIRQIEVGAFNGLASLNTLELFDNWLTVIPSGAFEYLSKLRELWLRNNPIESIPSYAFNRVPSLMRLDLGELKKLEYISEGAFEGLFNLKYLNLGMCNIKDMPNLTPLVGLEELEMSGNHFPEIRPGSFHGLSSLKKLWVMNSQVSLIERNAFDGLASLVELNLAHNNLSSLPHDLFTPLRYLVELHLHHNPWNCDCDILWLAWWLREYIPTNSTCCGRCHAPMHMRGRYLVEVDQASFQCSAPFIMDAPRDLNISEGRMAELKCRTPPMSSVKWLLPNGTVLSHASRHPRISVLNDGTLNFSHVLLSDTGVYTCMVTNVAGNSNASAYLNVSTAELNTSNYSFFTTVTVETTEISPEDTTRKYKPVPTTSTGYQPAYTTSTTVLIQTTRVPKQVAVPATDTTDKMQTSLDEVMKTTKIIIGCFVAVTLLAAAMLIVFYKLRKRHQQRSTVTAARTVEIIQVDEDIPAATSAAATAAPSGVSGEGAVVLPTIHDHINYNTYKPAHGAHWTENSLGNSLHPTVTTISEPYIIQTHTKDKVQETQI

Target ORF information:

RefSeq Version	XM_011516461.3
Organism	Homo sapiens(human)
Definition	Homo sapiens leucine rich repeat containing 4 (LRRC4), transcript variant X1, mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

XM_011516461.3

ORF Insert Sequence:

ATGAAGCTCT TGTGGCAGGT AACTGTGCAC CACCACACCT GGAATGCCAT CCTGCTCCCG 
TTCGTCTACC TCACGGCGCA AGTGTGGATT CTGTGTGCAG CCATCGCTGC TGCCGCCTCA 
GCCGGGCCCC AGAACTGCCC CTCCGTCTGC TCGTGCAGTA ACCAGTTCAG CAAGGTGGTG 
TGCACGCGCC GGGGCCTCTC CGAGGTCCCG CAGGGTATTC CCTCGAACAC CCGGTACCTC 
AACCTCATGG AGAACAACAT CCAGATGATC CAGGCCGACA CCTTCCGCCA CCTCCACCAC 
CTGGAGGTCC TGCAGTTGGG CAGGAACTCC ATCCGGCAGA TTGAGGTGGG GGCCTTCAAC 
GGCCTGGCCA GCCTCAACAC CCTGGAGCTG TTCGACAACT GGCTGACAGT CATCCCTAGC 
GGGGCCTTTG AATACCTGTC CAAGCTGCGG GAGCTCTGGC TTCGCAACAA CCCCATCGAA 
AGCATCCCCT CTTACGCCTT CAACCGGGTG CCCTCCCTCA TGCGCCTGGA CTTGGGGGAG 
CTCAAGAAGC TGGAGTATAT CTCTGAGGGA GCTTTTGAGG GGCTGTTCAA CCTCAAGTAT 
CTGAACTTGG GCATGTGCAA CATTAAAGAC ATGCCCAATC TCACCCCCCT GGTGGGGCTG 
GAGGAGCTGG AGATGTCAGG GAACCACTTC CCTGAGATCA GGCCTGGCTC CTTCCATGGC 
CTGAGCTCCC TCAAGAAGCT CTGGGTCATG AACTCACAGG TCAGCCTGAT TGAGCGGAAT 
GCTTTTGACG GGCTGGCTTC ACTTGTGGAA CTCAACTTGG CCCACAATAA CCTCTCTTCT 
TTGCCCCATG ACCTCTTTAC CCCGCTGAGG TACCTGGTGG AGTTGCATCT ACACCACAAC 
CCTTGGAACT GTGATTGTGA CATTCTGTGG CTAGCCTGGT GGCTTCGAGA GTATATACCC 
ACCAATTCCA CCTGCTGTGG CCGCTGTCAT GCTCCCATGC ACATGCGAGG CCGCTACCTC 
GTGGAGGTGG ACCAGGCCTC CTTCCAGTGC TCTGCCCCCT TCATCATGGA CGCACCTCGA 
GACCTCAACA TTTCTGAGGG TCGGATGGCA GAACTTAAGT GTCGGACTCC CCCTATGTCC 
TCCGTGAAGT GGTTGCTGCC CAATGGGACA GTGCTCAGCC ACGCCTCCCG CCACCCAAGG 
ATCTCTGTCC TCAACGACGG CACCTTGAAC TTTTCCCACG TGCTGCTTTC AGACACTGGG 
GTGTACACAT GCATGGTGAC CAATGTTGCA GGCAACTCCA ACGCCTCGGC CTACCTCAAT 
GTGAGCACGG CTGAGCTTAA CACCTCCAAC TACAGCTTCT TCACCACAGT AACAGTGGAG 
ACCACGGAGA TCTCGCCTGA GGACACAACG CGAAAGTACA AGCCTGTTCC TACCACGTCC 
ACTGGTTACC AGCCGGCATA TACCACCTCT ACCACGGTGC TCATTCAGAC TACCCGTGTG 
CCCAAGCAGG TGGCAGTACC CGCGACAGAC ACCACTGACA AGATGCAGAC CAGCCTGGAT 
GAAGTCATGA AGACCACCAA GATCATCATT GGCTGCTTTG TGGCAGTGAC TCTGCTAGCT 
GCCGCCATGT TGATTGTCTT CTATAAACTT CGTAAGCGGC ACCAGCAGCG GAGTACAGTC 
ACAGCCGCCC GGACTGTTGA GATAATCCAG GTGGACGAAG ACATCCCAGC AGCAACATCC 
GCAGCAGCAA CAGCAGCTCC GTCCGGTGTA TCAGGTGAGG GGGCAGTAGT GCTGCCCACA 
ATTCATGACC ATATTAACTA CAACACCTAC AAACCAGCAC ATGGGGCCCA CTGGACAGAA 
AACAGCCTGG GGAACTCTCT GCACCCCACA GTCACCACTA TCTCTGAACC TTATATAATT 
CAGACCCATA CCAAGGACAA GGTACAGGAA ACTCAAATAT GA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

LRRC4 ( XM_011516461.2 ) cDNA ORF clone, Homo sapiens(human) -> XP_011514763.1 Homo sapiens leucine rich repeat containing 4 (LRRC4), transcript variant X2, mRNA.

Price & Availability↑

CloneID	OHu30186
Clone ID Related Accession (Same CDS sequence)	NM_022143.4 , XM_017012505.1 , XM_011516461.3 , XM_011516461.2 , XM_011516461.1 , NM_022143.5
Accession Version	XM_011516461.2	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 1962bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2016-06-05
Organism	Homo sapiens(human)
Product	leucine-rich repeat-containing protein 4 isoform X1
Comment	Comment: MODEL REFSEQ: This record is predicted by automated computational analysis. This record is derived from a genomic sequence (NC_000007.14) annotated using gene prediction method: Gnomon, supported by mRNA and EST evidence. Also see: Documentation of NCBI's Annotation Process On Jun 6, 2016 this sequence version replaced XM_011516461.1. ##Genome-Annotation-Data-START## Annotation Provider :: NCBI Annotation Status :: Full annotation Annotation Version :: Homo sapiens Annotation Release 108 Annotation Pipeline :: NCBI eukaryotic genome annotation pipeline Annotation Software Version :: 7.0 Annotation Method :: Best-placed RefSeq; Gnomon Features Annotated :: Gene; mRNA; CDS; ncRNA ##Genome-Annotation-Data-END##

ATGAAGCTCT TGTGGCAGGT AACTGTGCAC CACCACACCT GGAATGCCAT CCTGCTCCCG 
TTCGTCTACC TCACGGCGCA AGTGTGGATT CTGTGTGCAG CCATCGCTGC TGCCGCCTCA 
GCCGGGCCCC AGAACTGCCC CTCCGTCTGC TCGTGCAGTA ACCAGTTCAG CAAGGTGGTG 
TGCACGCGCC GGGGCCTCTC CGAGGTCCCG CAGGGTATTC CCTCGAACAC CCGGTACCTC 
AACCTCATGG AGAACAACAT CCAGATGATC CAGGCCGACA CCTTCCGCCA CCTCCACCAC 
CTGGAGGTCC TGCAGTTGGG CAGGAACTCC ATCCGGCAGA TTGAGGTGGG GGCCTTCAAC 
GGCCTGGCCA GCCTCAACAC CCTGGAGCTG TTCGACAACT GGCTGACAGT CATCCCTAGC 
GGGGCCTTTG AATACCTGTC CAAGCTGCGG GAGCTCTGGC TTCGCAACAA CCCCATCGAA 
AGCATCCCCT CTTACGCCTT CAACCGGGTG CCCTCCCTCA TGCGCCTGGA CTTGGGGGAG 
CTCAAGAAGC TGGAGTATAT CTCTGAGGGA GCTTTTGAGG GGCTGTTCAA CCTCAAGTAT 
CTGAACTTGG GCATGTGCAA CATTAAAGAC ATGCCCAATC TCACCCCCCT GGTGGGGCTG 
GAGGAGCTGG AGATGTCAGG GAACCACTTC CCTGAGATCA GGCCTGGCTC CTTCCATGGC 
CTGAGCTCCC TCAAGAAGCT CTGGGTCATG AACTCACAGG TCAGCCTGAT TGAGCGGAAT 
GCTTTTGACG GGCTGGCTTC ACTTGTGGAA CTCAACTTGG CCCACAATAA CCTCTCTTCT 
TTGCCCCATG ACCTCTTTAC CCCGCTGAGG TACCTGGTGG AGTTGCATCT ACACCACAAC 
CCTTGGAACT GTGATTGTGA CATTCTGTGG CTAGCCTGGT GGCTTCGAGA GTATATACCC 
ACCAATTCCA CCTGCTGTGG CCGCTGTCAT GCTCCCATGC ACATGCGAGG CCGCTACCTC 
GTGGAGGTGG ACCAGGCCTC CTTCCAGTGC TCTGCCCCCT TCATCATGGA CGCACCTCGA 
GACCTCAACA TTTCTGAGGG TCGGATGGCA GAACTTAAGT GTCGGACTCC CCCTATGTCC 
TCCGTGAAGT GGTTGCTGCC CAATGGGACA GTGCTCAGCC ACGCCTCCCG CCACCCAAGG 
ATCTCTGTCC TCAACGACGG CACCTTGAAC TTTTCCCACG TGCTGCTTTC AGACACTGGG 
GTGTACACAT GCATGGTGAC CAATGTTGCA GGCAACTCCA ACGCCTCGGC CTACCTCAAT 
GTGAGCACGG CTGAGCTTAA CACCTCCAAC TACAGCTTCT TCACCACAGT AACAGTGGAG 
ACCACGGAGA TCTCGCCTGA GGACACAACG CGAAAGTACA AGCCTGTTCC TACCACGTCC 
ACTGGTTACC AGCCGGCATA TACCACCTCT ACCACGGTGC TCATTCAGAC TACCCGTGTG 
CCCAAGCAGG TGGCAGTACC CGCGACAGAC ACCACTGACA AGATGCAGAC CAGCCTGGAT 
GAAGTCATGA AGACCACCAA GATCATCATT GGCTGCTTTG TGGCAGTGAC TCTGCTAGCT 
GCCGCCATGT TGATTGTCTT CTATAAACTT CGTAAGCGGC ACCAGCAGCG GAGTACAGTC 
ACAGCCGCCC GGACTGTTGA GATAATCCAG GTGGACGAAG ACATCCCAGC AGCAACATCC 
GCAGCAGCAA CAGCAGCTCC GTCCGGTGTA TCAGGTGAGG GGGCAGTAGT GCTGCCCACA 
ATTCATGACC ATATTAACTA CAACACCTAC AAACCAGCAC ATGGGGCCCA CTGGACAGAA 
AACAGCCTGG GGAACTCTCT GCACCCCACA GTCACCACTA TCTCTGAACC TTATATAATT 
CAGACCCATA CCAAGGACAA GGTACAGGAA ACTCAAATAT GA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	XP_011514763.1
CDS	444..2405
Translation	MKLLWQVTVHHHTWNAILLPFVYLTAQVWILCAAIAAAASAGPQNCPSVCSCSNQFSKVVCTRRGLSEVPQGIPSNTRYLNLMENNIQMIQADTFRHLHHLEVLQLGRNSIRQIEVGAFNGLASLNTLELFDNWLTVIPSGAFEYLSKLRELWLRNNPIESIPSYAFNRVPSLMRLDLGELKKLEYISEGAFEGLFNLKYLNLGMCNIKDMPNLTPLVGLEELEMSGNHFPEIRPGSFHGLSSLKKLWVMNSQVSLIERNAFDGLASLVELNLAHNNLSSLPHDLFTPLRYLVELHLHHNPWNCDCDILWLAWWLREYIPTNSTCCGRCHAPMHMRGRYLVEVDQASFQCSAPFIMDAPRDLNISEGRMAELKCRTPPMSSVKWLLPNGTVLSHASRHPRISVLNDGTLNFSHVLLSDTGVYTCMVTNVAGNSNASAYLNVSTAELNTSNYSFFTTVTVETTEISPEDTTRKYKPVPTTSTGYQPAYTTSTTVLIQTTRVPKQVAVPATDTTDKMQTSLDEVMKTTKIIIGCFVAVTLLAAAMLIVFYKLRKRHQQRSTVTAARTVEIIQVDEDIPAATSAAATAAPSGVSGEGAVVLPTIHDHINYNTYKPAHGAHWTENSLGNSLHPTVTTISEPYIIQTHTKDKVQETQI

Target ORF information:

RefSeq Version	XM_011516461.2
Organism	Homo sapiens(human)
Definition	Homo sapiens leucine rich repeat containing 4 (LRRC4), transcript variant X2, mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

XM_011516461.2

ORF Insert Sequence:

ATGAAGCTCT TGTGGCAGGT AACTGTGCAC CACCACACCT GGAATGCCAT CCTGCTCCCG 
TTCGTCTACC TCACGGCGCA AGTGTGGATT CTGTGTGCAG CCATCGCTGC TGCCGCCTCA 
GCCGGGCCCC AGAACTGCCC CTCCGTCTGC TCGTGCAGTA ACCAGTTCAG CAAGGTGGTG 
TGCACGCGCC GGGGCCTCTC CGAGGTCCCG CAGGGTATTC CCTCGAACAC CCGGTACCTC 
AACCTCATGG AGAACAACAT CCAGATGATC CAGGCCGACA CCTTCCGCCA CCTCCACCAC 
CTGGAGGTCC TGCAGTTGGG CAGGAACTCC ATCCGGCAGA TTGAGGTGGG GGCCTTCAAC 
GGCCTGGCCA GCCTCAACAC CCTGGAGCTG TTCGACAACT GGCTGACAGT CATCCCTAGC 
GGGGCCTTTG AATACCTGTC CAAGCTGCGG GAGCTCTGGC TTCGCAACAA CCCCATCGAA 
AGCATCCCCT CTTACGCCTT CAACCGGGTG CCCTCCCTCA TGCGCCTGGA CTTGGGGGAG 
CTCAAGAAGC TGGAGTATAT CTCTGAGGGA GCTTTTGAGG GGCTGTTCAA CCTCAAGTAT 
CTGAACTTGG GCATGTGCAA CATTAAAGAC ATGCCCAATC TCACCCCCCT GGTGGGGCTG 
GAGGAGCTGG AGATGTCAGG GAACCACTTC CCTGAGATCA GGCCTGGCTC CTTCCATGGC 
CTGAGCTCCC TCAAGAAGCT CTGGGTCATG AACTCACAGG TCAGCCTGAT TGAGCGGAAT 
GCTTTTGACG GGCTGGCTTC ACTTGTGGAA CTCAACTTGG CCCACAATAA CCTCTCTTCT 
TTGCCCCATG ACCTCTTTAC CCCGCTGAGG TACCTGGTGG AGTTGCATCT ACACCACAAC 
CCTTGGAACT GTGATTGTGA CATTCTGTGG CTAGCCTGGT GGCTTCGAGA GTATATACCC 
ACCAATTCCA CCTGCTGTGG CCGCTGTCAT GCTCCCATGC ACATGCGAGG CCGCTACCTC 
GTGGAGGTGG ACCAGGCCTC CTTCCAGTGC TCTGCCCCCT TCATCATGGA CGCACCTCGA 
GACCTCAACA TTTCTGAGGG TCGGATGGCA GAACTTAAGT GTCGGACTCC CCCTATGTCC 
TCCGTGAAGT GGTTGCTGCC CAATGGGACA GTGCTCAGCC ACGCCTCCCG CCACCCAAGG 
ATCTCTGTCC TCAACGACGG CACCTTGAAC TTTTCCCACG TGCTGCTTTC AGACACTGGG 
GTGTACACAT GCATGGTGAC CAATGTTGCA GGCAACTCCA ACGCCTCGGC CTACCTCAAT 
GTGAGCACGG CTGAGCTTAA CACCTCCAAC TACAGCTTCT TCACCACAGT AACAGTGGAG 
ACCACGGAGA TCTCGCCTGA GGACACAACG CGAAAGTACA AGCCTGTTCC TACCACGTCC 
ACTGGTTACC AGCCGGCATA TACCACCTCT ACCACGGTGC TCATTCAGAC TACCCGTGTG 
CCCAAGCAGG TGGCAGTACC CGCGACAGAC ACCACTGACA AGATGCAGAC CAGCCTGGAT 
GAAGTCATGA AGACCACCAA GATCATCATT GGCTGCTTTG TGGCAGTGAC TCTGCTAGCT 
GCCGCCATGT TGATTGTCTT CTATAAACTT CGTAAGCGGC ACCAGCAGCG GAGTACAGTC 
ACAGCCGCCC GGACTGTTGA GATAATCCAG GTGGACGAAG ACATCCCAGC AGCAACATCC 
GCAGCAGCAA CAGCAGCTCC GTCCGGTGTA TCAGGTGAGG GGGCAGTAGT GCTGCCCACA 
ATTCATGACC ATATTAACTA CAACACCTAC AAACCAGCAC ATGGGGCCCA CTGGACAGAA 
AACAGCCTGG GGAACTCTCT GCACCCCACA GTCACCACTA TCTCTGAACC TTATATAATT 
CAGACCCATA CCAAGGACAA GGTACAGGAA ACTCAAATAT GA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

LRRC4 ( XM_011516461.1 ) cDNA ORF clone, Homo sapiens(human) -> XP_011514763.1 Homo sapiens leucine rich repeat containing 4 (LRRC4), transcript variant X1, mRNA.

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CloneID	OHu30186
Clone ID Related Accession (Same CDS sequence)	NM_022143.4 , XM_017012505.1 , XM_011516461.3 , XM_011516461.2 , XM_011516461.1 , NM_022143.5
Accession Version	XM_011516461.1	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 1962bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2015-03-11
Organism	Homo sapiens(Human)
Product	leucine-rich repeat-containing protein 4 isoform X1
Comment

ATGAAGCTCT TGTGGCAGGT AACTGTGCAC CACCACACCT GGAATGCCAT CCTGCTCCCG 
TTCGTCTACC TCACGGCGCA AGTGTGGATT CTGTGTGCAG CCATCGCTGC TGCCGCCTCA 
GCCGGGCCCC AGAACTGCCC CTCCGTCTGC TCGTGCAGTA ACCAGTTCAG CAAGGTGGTG 
TGCACGCGCC GGGGCCTCTC CGAGGTCCCG CAGGGTATTC CCTCGAACAC CCGGTACCTC 
AACCTCATGG AGAACAACAT CCAGATGATC CAGGCCGACA CCTTCCGCCA CCTCCACCAC 
CTGGAGGTCC TGCAGTTGGG CAGGAACTCC ATCCGGCAGA TTGAGGTGGG GGCCTTCAAC 
GGCCTGGCCA GCCTCAACAC CCTGGAGCTG TTCGACAACT GGCTGACAGT CATCCCTAGC 
GGGGCCTTTG AATACCTGTC CAAGCTGCGG GAGCTCTGGC TTCGCAACAA CCCCATCGAA 
AGCATCCCCT CTTACGCCTT CAACCGGGTG CCCTCCCTCA TGCGCCTGGA CTTGGGGGAG 
CTCAAGAAGC TGGAGTATAT CTCTGAGGGA GCTTTTGAGG GGCTGTTCAA CCTCAAGTAT 
CTGAACTTGG GCATGTGCAA CATTAAAGAC ATGCCCAATC TCACCCCCCT GGTGGGGCTG 
GAGGAGCTGG AGATGTCAGG GAACCACTTC CCTGAGATCA GGCCTGGCTC CTTCCATGGC 
CTGAGCTCCC TCAAGAAGCT CTGGGTCATG AACTCACAGG TCAGCCTGAT TGAGCGGAAT 
GCTTTTGACG GGCTGGCTTC ACTTGTGGAA CTCAACTTGG CCCACAATAA CCTCTCTTCT 
TTGCCCCATG ACCTCTTTAC CCCGCTGAGG TACCTGGTGG AGTTGCATCT ACACCACAAC 
CCTTGGAACT GTGATTGTGA CATTCTGTGG CTAGCCTGGT GGCTTCGAGA GTATATACCC 
ACCAATTCCA CCTGCTGTGG CCGCTGTCAT GCTCCCATGC ACATGCGAGG CCGCTACCTC 
GTGGAGGTGG ACCAGGCCTC CTTCCAGTGC TCTGCCCCCT TCATCATGGA CGCACCTCGA 
GACCTCAACA TTTCTGAGGG TCGGATGGCA GAACTTAAGT GTCGGACTCC CCCTATGTCC 
TCCGTGAAGT GGTTGCTGCC CAATGGGACA GTGCTCAGCC ACGCCTCCCG CCACCCAAGG 
ATCTCTGTCC TCAACGACGG CACCTTGAAC TTTTCCCACG TGCTGCTTTC AGACACTGGG 
GTGTACACAT GCATGGTGAC CAATGTTGCA GGCAACTCCA ACGCCTCGGC CTACCTCAAT 
GTGAGCACGG CTGAGCTTAA CACCTCCAAC TACAGCTTCT TCACCACAGT AACAGTGGAG 
ACCACGGAGA TCTCGCCTGA GGACACAACG CGAAAGTACA AGCCTGTTCC TACCACGTCC 
ACTGGTTACC AGCCGGCATA TACCACCTCT ACCACGGTGC TCATTCAGAC TACCCGTGTG 
CCCAAGCAGG TGGCAGTACC CGCGACAGAC ACCACTGACA AGATGCAGAC CAGCCTGGAT 
GAAGTCATGA AGACCACCAA GATCATCATT GGCTGCTTTG TGGCAGTGAC TCTGCTAGCT 
GCCGCCATGT TGATTGTCTT CTATAAACTT CGTAAGCGGC ACCAGCAGCG GAGTACAGTC 
ACAGCCGCCC GGACTGTTGA GATAATCCAG GTGGACGAAG ACATCCCAGC AGCAACATCC 
GCAGCAGCAA CAGCAGCTCC GTCCGGTGTA TCAGGTGAGG GGGCAGTAGT GCTGCCCACA 
ATTCATGACC ATATTAACTA CAACACCTAC AAACCAGCAC ATGGGGCCCA CTGGACAGAA 
AACAGCCTGG GGAACTCTCT GCACCCCACA GTCACCACTA TCTCTGAACC TTATATAATT 
CAGACCCATA CCAAGGACAA GGTACAGGAA ACTCAAATAT GA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq

XP_011514763.1

Translation

MKLLWQVTVHHHTWNAILLPFVYLTAQVWILCAAIAAAASAGPQNCPSVCSCSNQFSKVVCTRRGLSEVPQGIPSNTRYLNLMENNIQMIQADTFRHLHHLEVLQLGRNSIRQIEVGAFNGLASLNTLELFDNWLTVIPSGAFEYLSKLRELWLRNNPIESIPSYAFNRVPSLMRLDLGELKKLEYISEGAFEGLFNLKYLNLGMCNIKDMPNLTPLVGLEELEMSGNHFPEIRPGSFHGLSSLKKLWVMNSQVSLIERNAFDGLASLVELNLAHNNLSSLPHDLFTPLRYLVELHLHHNPWNCDCDILWLAWWLREYIPTNSTCCGRCHAPMHMRGRYLVEVDQASFQCSAPFIMDAPRDLNISEGRMAELKCRTPPMSSVKWLLPNGTVLSHASRHPRISVLNDGTLNFSHVLLSDTGVYTCMVTNVAGNSNASAYLNVSTAELNTSNYSFFTTVTVETTEISPEDTTRKYKPVPTTSTGYQPAYTTSTTVLIQTTRVPKQVAVPATDTTDKMQTSLDEVMKTTKIIIGCFVAVTLLAAAMLIVFYKLRKRHQQRSTVTAARTVEIIQVDEDIPAATSAAATAAPSGVSGEGAVVLPTIHDHINYNTYKPAHGAHWTENSLGNSLHPTVTTISEPYIIQTHTKDKVQETQI

Target ORF information:

RefSeq Version	XM_011516461.1
Organism	Homo sapiens(Human)
Definition	Homo sapiens leucine rich repeat containing 4 (LRRC4), transcript variant X1, mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

XM_011516461.1

ORF Insert Sequence:

ATGAAGCTCT TGTGGCAGGT AACTGTGCAC CACCACACCT GGAATGCCAT CCTGCTCCCG 
TTCGTCTACC TCACGGCGCA AGTGTGGATT CTGTGTGCAG CCATCGCTGC TGCCGCCTCA 
GCCGGGCCCC AGAACTGCCC CTCCGTCTGC TCGTGCAGTA ACCAGTTCAG CAAGGTGGTG 
TGCACGCGCC GGGGCCTCTC CGAGGTCCCG CAGGGTATTC CCTCGAACAC CCGGTACCTC 
AACCTCATGG AGAACAACAT CCAGATGATC CAGGCCGACA CCTTCCGCCA CCTCCACCAC 
CTGGAGGTCC TGCAGTTGGG CAGGAACTCC ATCCGGCAGA TTGAGGTGGG GGCCTTCAAC 
GGCCTGGCCA GCCTCAACAC CCTGGAGCTG TTCGACAACT GGCTGACAGT CATCCCTAGC 
GGGGCCTTTG AATACCTGTC CAAGCTGCGG GAGCTCTGGC TTCGCAACAA CCCCATCGAA 
AGCATCCCCT CTTACGCCTT CAACCGGGTG CCCTCCCTCA TGCGCCTGGA CTTGGGGGAG 
CTCAAGAAGC TGGAGTATAT CTCTGAGGGA GCTTTTGAGG GGCTGTTCAA CCTCAAGTAT 
CTGAACTTGG GCATGTGCAA CATTAAAGAC ATGCCCAATC TCACCCCCCT GGTGGGGCTG 
GAGGAGCTGG AGATGTCAGG GAACCACTTC CCTGAGATCA GGCCTGGCTC CTTCCATGGC 
CTGAGCTCCC TCAAGAAGCT CTGGGTCATG AACTCACAGG TCAGCCTGAT TGAGCGGAAT 
GCTTTTGACG GGCTGGCTTC ACTTGTGGAA CTCAACTTGG CCCACAATAA CCTCTCTTCT 
TTGCCCCATG ACCTCTTTAC CCCGCTGAGG TACCTGGTGG AGTTGCATCT ACACCACAAC 
CCTTGGAACT GTGATTGTGA CATTCTGTGG CTAGCCTGGT GGCTTCGAGA GTATATACCC 
ACCAATTCCA CCTGCTGTGG CCGCTGTCAT GCTCCCATGC ACATGCGAGG CCGCTACCTC 
GTGGAGGTGG ACCAGGCCTC CTTCCAGTGC TCTGCCCCCT TCATCATGGA CGCACCTCGA 
GACCTCAACA TTTCTGAGGG TCGGATGGCA GAACTTAAGT GTCGGACTCC CCCTATGTCC 
TCCGTGAAGT GGTTGCTGCC CAATGGGACA GTGCTCAGCC ACGCCTCCCG CCACCCAAGG 
ATCTCTGTCC TCAACGACGG CACCTTGAAC TTTTCCCACG TGCTGCTTTC AGACACTGGG 
GTGTACACAT GCATGGTGAC CAATGTTGCA GGCAACTCCA ACGCCTCGGC CTACCTCAAT 
GTGAGCACGG CTGAGCTTAA CACCTCCAAC TACAGCTTCT TCACCACAGT AACAGTGGAG 
ACCACGGAGA TCTCGCCTGA GGACACAACG CGAAAGTACA AGCCTGTTCC TACCACGTCC 
ACTGGTTACC AGCCGGCATA TACCACCTCT ACCACGGTGC TCATTCAGAC TACCCGTGTG 
CCCAAGCAGG TGGCAGTACC CGCGACAGAC ACCACTGACA AGATGCAGAC CAGCCTGGAT 
GAAGTCATGA AGACCACCAA GATCATCATT GGCTGCTTTG TGGCAGTGAC TCTGCTAGCT 
GCCGCCATGT TGATTGTCTT CTATAAACTT CGTAAGCGGC ACCAGCAGCG GAGTACAGTC 
ACAGCCGCCC GGACTGTTGA GATAATCCAG GTGGACGAAG ACATCCCAGC AGCAACATCC 
GCAGCAGCAA CAGCAGCTCC GTCCGGTGTA TCAGGTGAGG GGGCAGTAGT GCTGCCCACA 
ATTCATGACC ATATTAACTA CAACACCTAC AAACCAGCAC ATGGGGCCCA CTGGACAGAA 
AACAGCCTGG GGAACTCTCT GCACCCCACA GTCACCACTA TCTCTGAACC TTATATAATT 
CAGACCCATA CCAAGGACAA GGTACAGGAA ACTCAAATAT GA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

PubMed

The D Domain of LRRC4 anchors ERK1/2 in the cytoplasm and competitively inhibits MEK/ERK activation in glioma cells.
Journal of hematology & oncology9(1)130(2016 11)
Wang Z,Guo Q,Wang R,Xu G,Li P,Sun Y,She X,Liu Q,Chen Q,Yu Z,Liu C,Xiong J,Li G,Wu M

Low expression of miR-381 is a favorite prognosis factor and enhances the chemosensitivity of osteosarcoma.
Oncotarget7(42)68585-68596(2016 Oct)
Li Y,Zhao C,Yu Z,Chen J,She X,Li P,Liu C,Zhang Y,Feng J,Fu H,Wang B,Kuang L,Li L,Lv G,Wu M

LRRC4 haplotypes are associated with pituitary adenoma in a Chinese population.
Medical oncology (Northwood, London, England)31(4)888(2014 Apr)
Xiao L,Tu C,Chen S,Yu Z,Lei Q,Wang Z,Xu G,Wu M,Li G

Disturbing miR-182 and -381 inhibits BRD7 transcription and glioma growth by directly targeting LRRC4.
PloS one9(1)e84146(2014)
Tang H,Wang Z,Liu Q,Liu X,Wu M,Li G

LRRC4 inhibits glioma cell growth and invasion through a miR-185-dependent pathway.
Current cancer drug targets12(8)1032-42(2012 Oct)
Tang H,Wang Z,Liu X,Liu Q,Xu G,Li G,Wu M

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LRRC4 cDNA ORF clone, Homo sapiens(human)

Gene

Clones

gRNAs

Related articles in PubMed

Target ORF information:

Target ORF information:

ORF Insert Sequence:

Target ORF information:

Target ORF information:

ORF Insert Sequence:

Target ORF information:

Target ORF information:

ORF Insert Sequence:

Target ORF information:

Target ORF information:

ORF Insert Sequence:

Target ORF information:

Target ORF information:

ORF Insert Sequence:

Target ORF information:

Target ORF information:

ORF Insert Sequence:

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