RRM1 cDNA ORF clone, Homo sapiens(human)

Gene
Clones
gRNAs

Summary

Gene Symbol	RRM1
Entrez Gene ID	6240
Full Name	ribonucleotide reductase catalytic subunit M1
Synonyms	R1,RIR1,RR1
General protein information	Preferred Names ribonucleotide reductase catalytic subunit M1 Names ribonucleoside-diphosphate reductase large subunit ribonucleoside-diphosphate reductase subunit M1 ribonucleotide reductase M1 polypeptide ribonucleotide reductase, R1 subunit
Gene Type	protein-coding
Organism	Homo sapiens(human)
Genome	Chromosome: 11 Map Location: 11p15.4
Summary	This gene encodes the large and catalytic subunit of ribonucleotide reductase, an enzyme essential for the conversion of ribonucleotides into deoxyribonucleotides. A pool of available deoxyribonucleotides is important for DNA replication during S phase of the cell cycle as well as multiple DNA repair processes. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Dec 2015].
Disorder MIM:	180410

mRNA and Protein(s)

mRNA	Protein	Name
NM_001033.4	NP_001024.1	ribonucleoside-diphosphate reductase large subunit isoform 1
NM_001318065.1	NP_001304994.1	ribonucleoside-diphosphate reductase large subunit isoform 3
NM_001033.3	NP_001024.1	ribonucleoside-diphosphate reductase large subunit
NM_001330193.1	NP_001317122.1	ribonucleoside-diphosphate reductase large subunit isoform 4
NM_001033.5	NP_001024.1	ribonucleoside-diphosphate reductase large subunit isoform 1
NM_001318064.1	NP_001304993.1	ribonucleoside-diphosphate reductase large subunit isoform 2

Pathways from BioSystems

Homologies

Canis lupus familiaris (dog)	RRM1	XP_534027.2
Mus musculus (house mouse)	Rrm1	NP_033129.2
Gallus gallus (chicken)	RRM1	NP_001026008.1
Saccharomyces cerevisiae (baker's yeast)	RNR3	NP_012198.3
Eremothecium gossypii	AGOS_ADL057W	NP_984039.2
Schizosaccharomyces pombe (fission yeast)	cdc22	NP_594491.1
Pan troglodytes (chimpanzee)	RRM1	XP_001160029.1
Bos taurus (cattle)	RRM1	NP_001106767.1
Rattus norvegicus (Norway rat)	Rrm1	NP_001013254.1
Caenorhabditis elegans (roundworm)	rnr-1	NP_499039.1
Saccharomyces cerevisiae (baker's yeast)	RNR1	NP_010993.1
Oryza sativa (rice)	Os06g0168600	NP_001056926.1
Danio rerio (zebrafish)	rrm1	NP_571530.1
Magnaporthe oryzae (rice blast fungus)	MGG_07000	XP_003709756.1
Neurospora crassa	NCU03539	XP_956818.1
Xenopus tropicalis (tropical clawed frog)	rrm1	NP_001120566.1
Homo sapiens (human)	RRM1	NP_001024.1
	RRM1	XP_001113010.1
Drosophila melanogaster (fruit fly)	RnrL	NP_477027.1
Anopheles gambiae (African malaria mosquito)	AgaP_AGAP010198	XP_554103.3
Kluyveromyces lactis	KLLA0C07887g	XP_452551.1
Arabidopsis thaliana (thale cress)	RNR1	NP_179770.1

Gene Ontology
Bibliography

Related articles in PubMed

Effect of ribonucleotide reductase M1 expression on overall survival in patients with pancreatic cancer receiving gemcitabine chemotherapy: A literature-based meta-analysis.
Han QL, Zhou YH, Lyu Y, Yan H, Dai GH
Journal of clinical pharmacy and therapeutics(2017 Dec)

Clinical pharmacology and clinical trials of ribonucleotide reductase inhibitors: is it a viable cancer therapy?
Mannargudi MB, Deb S
Journal of cancer research and clinical oncology143(8)1499-1529(2017 Aug)

GeneRIFs: Gene References Into Functions What's a GeneRIF?

RRM1 and ERCC wild type alleles are risk-reducing factor for Coronary artery disease (CAD). Also, carrying RRM1 A allele might have a protective effect for smokers.
Title: RRM1, RRM2 and ERCC2 Gene Polymorphisms in Coronary Artery Disease.

Based on the results of clinical trials, we conclude that Ribonucleotide reductase (RR) enzymes (RR1 and RR2)inhibitors are viable treatment options, either as a monotherapy or as a combination in cancer chemotherapy. With the recent advances made in cancer biology, further development of RR inhibitors with improved efficacy and reduced toxicity is possible for treatment of variety of cancers.
Title: Clinical pharmacology and clinical trials of ribonucleotide reductase inhibitors: is it a viable cancer therapy?

findings suggest that the up-regulated RRM1 and hTrx1 in colorectal cancer directly interact with each other and promote RR activity, resulting in enhanced DNA synthesis and cancer malignancy.
Title: Physical interaction between human ribonucleotide reductase large subunit and thioredoxin increases colorectal cancer malignancy.

RRM1/RRM2B enzyme is capable of retaining activity in hypoxia and therefore is favored over RRM1/RRM2 in order to preserve ongoing replication and avoid the accumulation of DNA damage in hypoxic cells.
Title: Ribonucleotide Reductase Requires Subunit Switching in Hypoxia to Maintain DNA Replication.

RRM1 single nucleotide polymorphism is associated with Non-Small-Cell Lung Cancer.
Title: Correlation of DNA Repair Gene Polymorphisms With Clinical Outcome in Patients With Locally Advanced Non-Small-Cell Lung Cancer Receiving Induction Chemotherapy Followed by Surgery.

The following RRM1 gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the RRM1 cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1⁺/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.

***CloneID	Accession No.	Definition	**Vector	*Turnaround time	Price (USD)
OHu19014	NM_001033.5 Latest version!	Homo sapiens ribonucleotide reductase catalytic subunit M1 (RRM1), transcript variant 1, mRNA.	pcDNA3.1-C-(k)DYK or customized vector	in pcDNA3.1-C-(k)DYK	$189.50-$265.30 $379.00
OHu60335	NM_001318064.1 Latest version!	Homo sapiens ribonucleotide reductase catalytic subunit M1 (RRM1), transcript variant 2, mRNA.	pcDNA3.1-C-(k)DYK or customized vector	5-7	$391.30 $559.00
OHu60336	NM_001330193.1 Latest version!	Homo sapiens ribonucleotide reductase catalytic subunit M1 (RRM1), transcript variant 4, mRNA.	pcDNA3.1-C-(k)DYK or customized vector	5-7	$307.30 $439.00
OHu60337	NM_001318065.1 Latest version!	Homo sapiens ribonucleotide reductase catalytic subunit M1 (RRM1), transcript variant 3, mRNA.	pcDNA3.1-C-(k)DYK or customized vector	5-7	$223.30 $319.00
View Old Accession Versions >>
OHu19014	NM_001033.3	Homo sapiens ribonucleotide reductase M1 (RRM1), mRNA.	pcDNA3.1-C-(k)DYK or customized vector	in pcDNA3.1-C-(k)DYK	$189.50-$265.30 $379.00
OHu19014	NM_001033.4	Homo sapiens ribonucleotide reductase catalytic subunit M1 (RRM1), transcript variant 1, mRNA.	pcDNA3.1-C-(k)DYK or customized vector	in pcDNA3.1-C-(k)DYK	$189.50-$265.30 $379.00
Hide Old Accession Versions >>

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***One clone ID might be correlated to multiple accession numbers, which share the same CDS sequence.

Reference Sequences (Refseq)

RRM1 ( NM_001033.4 ) cDNA ORF clone, Homo sapiens(human) -> NP_001024.1 Homo sapiens ribonucleotide reductase catalytic subunit M1 (RRM1), transcript variant 1, mRNA.

Price & Availability↑

CloneID	OHu19014
Clone ID Related Accession (Same CDS sequence)	NM_001033.4 , NM_001033.3 , NM_001033.5
Accession Version	NM_001033.4	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 2379bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2017-10-08
Organism	Homo sapiens(human)
Product	ribonucleoside-diphosphate reductase large subunit isoform 1
Comment	Comment: REVIEWED REFSEQ: This record has been curated by NCBI staff. The reference sequence was derived from AC015689.12, BP229960.1, BC006498.2, X59617.1, BQ775841.1 and CB853003.1. On Dec 22, 2015 this sequence version replaced NM_001033.3. Transcript Variant: This variant (1) represents the longest transcript and encodes the longest isoform (1). Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: SRR1803616.32249.1, SRR1803615.166019.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA1965299, SAMEA1966682 [ECO:0000348] ##Evidence-Data-END## COMPLETENESS: full length.

ATGCATGTGA TCAAGCGAGA TGGCCGCCAA GAACGAGTCA TGTTTGACAA AATTACATCT 
CGAATCCAGA AGCTTTGTTA TGGACTCAAT ATGGATTTTG TTGATCCTGC TCAGATCACC 
ATGAAAGTAA TCCAAGGCTT GTACAGTGGG GTCACCACAG TGGAACTAGA TACTTTGGCT 
GCTGAAACAG CTGCAACCTT GACTACTAAG CACCCTGACT ATGCTATCCT GGCAGCCAGG 
ATCGCTGTCT CTAACTTGCA CAAAGAAACA AAGAAAGTGT TCAGTGATGT GATGGAAGAC 
CTCTATAACT ACATAAATCC ACATAATGGC AAACACTCTC CCATGGTGGC CAAGTCAACA 
TTGGATATTG TTCTGGCCAA TAAAGATCGC CTGAATTCTG CTATTATCTA TGACCGAGAT 
TTCTCTTACA ATTACTTCGG CTTTAAGACG CTAGAGCGGT CTTATTTGTT GAAGATCAAT 
GGAAAAGTGG CTGAAAGACC ACAACATATG TTGATGAGAG TATCTGTTGG GATCCACAAA 
GAAGACATTG ATGCAGCAAT TGAAACATAT AATCTTCTTT CTGAGAGGTG GTTTACTCAT 
GCTTCGCCCA CTCTCTTCAA TGCTGGTACC AACCGCCCAC AACTTTCTAG CTGTTTTCTT 
CTGAGTATGA AAGATGACAG CATTGAAGGC ATTTATGACA CTCTAAAGCA ATGTGCATTG 
ATTTCTAAGT CTGCTGGAGG AATTGGTGTT GCTGTGAGTT GTATTCGGGC TACTGGCAGC 
TACATTGCTG GGACTAATGG CAATTCCAAT GGCCTTGTAC CGATGCTGAG AGTATATAAC 
AACACAGCTC GATATGTGGA TCAAGGTGGG AACAAGCGTC CTGGGGCATT TGCTATTTAC 
CTGGAGCCTT GGCATTTAGA CATCTTTGAA TTCCTTGATT TAAAGAAGAA CACAGGAAAG 
GAAGAGCAGC GTGCCAGAGA TCTTTTCTTT GCTCTTTGGA TTCCGGATCT CTTCATGAAA 
CGAGTGGAGA CTAATCAGGA CTGGTCTTTG ATGTGTCCAA ATGAGTGTCC TGGTCTGGAT 
GAGGTTTGGG GAGAGGAATT TGAGAAACTA TATGCAAGTT ATGAGAAACA AGGTCGTGTC 
CGCAAAGTTG TAAAAGCTCA GCAGCTTTGG TATGCCATCA TTGAGTCTCA GACGGAAACA 
GGCACCCCGT ATATGCTCTA CAAAGATTCC TGTAATCGAA AGAGCAACCA GCAGAACCTG 
GGAACCATCA AATGCAGCAA CCTGTGCACA GAAATAGTGG AGTACACCAG CAAAGATGAG 
GTTGCTGTTT GTAATTTGGC TTCCCTGGCC CTGAATATGT ATGTCACATC AGAACACACA 
TACGACTTTA AGAAGTTGGC TGAAGTCACT AAAGTCGTTG TCCGAAACTT GAATAAAATT 
ATTGATATAA ACTACTATCC TGTACCAGAG GCATGCCTAT CAAATAAACG CCATCGCCCC 
ATTGGAATTG GGGTACAAGG TCTGGCAGAT GCTTTTATCC TGATGAGATA CCCTTTTGAG 
AGTGCAGAAG CCCAGTTACT GAATAAGCAG ATCTTTGAAA CTATTTATTA TGGTGCTCTG 
GAAGCCAGCT GTGACCTTGC CAAGGAGCAG GGCCCATACG AAACCTATGA GGGCTCTCCA 
GTTAGCAAAG GAATTCTTCA GTATGATATG TGGAATGTTA CTCCTACAGA CCTATGGGAC 
TGGAAGGTTC TCAAGGAGAA GATTGCAAAG TATGGTATAA GAAACAGTTT ACTTATTGCC 
CCGATGCCTA CAGCTTCCAC TGCTCAGATC CTGGGGAATA ATGAGTCCAT TGAACCTTAC 
ACCAGCAACA TCTATACTCG CAGAGTCTTG TCAGGAGAAT TTCAGATTGT AAATCCTCAC 
TTATTGAAAG ATCTTACCGA GCGGGGCCTA TGGCATGAAG AGATGAAAAA CCAGATTATT 
GCATGCAATG GCTCTATTCA GAGCATACCA GAAATTCCTG ATGACCTGAA GCAACTTTAT 
AAAACTGTGT GGGAAATCTC TCAGAAAACT GTTCTCAAGA TGGCAGCTGA GAGAGGTGCT 
TTCATTGATC AAAGCCAATC TTTGAACATC CACATTGCTG AGCCTAACTA TGGCAAACTC 
ACTAGTATGC ACTTCTACGG CTGGAAGCAG GGTTTGAAGA CTGGGATGTA TTATTTAAGG 
ACAAGACCAG CGGCTAATCC AATCCAGTTC ACTCTAAATA AGGAGAAGCT AAAAGATAAA 
GAAAAGGTAT CAAAAGAGGA AGAAGAGAAG GAGAGGAACA CAGCAGCCAT GGTGTGCTCT 
TTGGAGAATA GAGATGAATG TCTGATGTGT GGATCCTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_001024.1
CDS	329..2707
Translation	MHVIKRDGRQERVMFDKITSRIQKLCYGLNMDFVDPAQITMKVIQGLYSGVTTVELDTLAAETAATLTTKHPDYAILAARIAVSNLHKETKKVFSDVMEDLYNYINPHNGKHSPMVAKSTLDIVLANKDRLNSAIIYDRDFSYNYFGFKTLERSYLLKINGKVAERPQHMLMRVSVGIHKEDIDAAIETYNLLSERWFTHASPTLFNAGTNRPQLSSCFLLSMKDDSIEGIYDTLKQCALISKSAGGIGVAVSCIRATGSYIAGTNGNSNGLVPMLRVYNNTARYVDQGGNKRPGAFAIYLEPWHLDIFEFLDLKKNTGKEEQRARDLFFALWIPDLFMKRVETNQDWSLMCPNECPGLDEVWGEEFEKLYASYEKQGRVRKVVKAQQLWYAIIESQTETGTPYMLYKDSCNRKSNQQNLGTIKCSNLCTEIVEYTSKDEVAVCNLASLALNMYVTSEHTYDFKKLAEVTKVVVRNLNKIIDINYYPVPEACLSNKRHRPIGIGVQGLADAFILMRYPFESAEAQLLNKQIFETIYYGALEASCDLAKEQGPYETYEGSPVSKGILQYDMWNVTPTDLWDWKVLKEKIAKYGIRNSLLIAPMPTASTAQILGNNESIEPYTSNIYTRRVLSGEFQIVNPHLLKDLTERGLWHEEMKNQIIACNGSIQSIPEIPDDLKQLYKTVWEISQKTVLKMAAERGAFIDQSQSLNIHIAEPNYGKLTSMHFYGWKQGLKTGMYYLRTRPAANPIQFTLNKEKLKDKEKVSKEEEEKERNTAAMVCSLENRDECLMCGS

Target ORF information:

RefSeq Version	NM_001033.4
Organism	Homo sapiens(human)
Definition	Homo sapiens ribonucleotide reductase catalytic subunit M1 (RRM1), transcript variant 1, mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_001033.4

ORF Insert Sequence:

ATGCATGTGA TCAAGCGAGA TGGCCGCCAA GAACGAGTCA TGTTTGACAA AATTACATCT 
CGAATCCAGA AGCTTTGTTA TGGACTCAAT ATGGATTTTG TTGATCCTGC TCAGATCACC 
ATGAAAGTAA TCCAAGGCTT GTACAGTGGG GTCACCACAG TGGAACTAGA TACTTTGGCT 
GCTGAAACAG CTGCAACCTT GACTACTAAG CACCCTGACT ATGCTATCCT GGCAGCCAGG 
ATCGCTGTCT CTAACTTGCA CAAAGAAACA AAGAAAGTGT TCAGTGATGT GATGGAAGAC 
CTCTATAACT ACATAAATCC ACATAATGGC AAACACTCTC CCATGGTGGC CAAGTCAACA 
TTGGATATTG TTCTGGCCAA TAAAGATCGC CTGAATTCTG CTATTATCTA TGACCGAGAT 
TTCTCTTACA ATTACTTCGG CTTTAAGACG CTAGAGCGGT CTTATTTGTT GAAGATCAAT 
GGAAAAGTGG CTGAAAGACC ACAACATATG TTGATGAGAG TATCTGTTGG GATCCACAAA 
GAAGACATTG ATGCAGCAAT TGAAACATAT AATCTTCTTT CTGAGAGGTG GTTTACTCAT 
GCTTCGCCCA CTCTCTTCAA TGCTGGTACC AACCGCCCAC AACTTTCTAG CTGTTTTCTT 
CTGAGTATGA AAGATGACAG CATTGAAGGC ATTTATGACA CTCTAAAGCA ATGTGCATTG 
ATTTCTAAGT CTGCTGGAGG AATTGGTGTT GCTGTGAGTT GTATTCGGGC TACTGGCAGC 
TACATTGCTG GGACTAATGG CAATTCCAAT GGCCTTGTAC CGATGCTGAG AGTATATAAC 
AACACAGCTC GATATGTGGA TCAAGGTGGG AACAAGCGTC CTGGGGCATT TGCTATTTAC 
CTGGAGCCTT GGCATTTAGA CATCTTTGAA TTCCTTGATT TAAAGAAGAA CACAGGAAAG 
GAAGAGCAGC GTGCCAGAGA TCTTTTCTTT GCTCTTTGGA TTCCGGATCT CTTCATGAAA 
CGAGTGGAGA CTAATCAGGA CTGGTCTTTG ATGTGTCCAA ATGAGTGTCC TGGTCTGGAT 
GAGGTTTGGG GAGAGGAATT TGAGAAACTA TATGCAAGTT ATGAGAAACA AGGTCGTGTC 
CGCAAAGTTG TAAAAGCTCA GCAGCTTTGG TATGCCATCA TTGAGTCTCA GACGGAAACA 
GGCACCCCGT ATATGCTCTA CAAAGATTCC TGTAATCGAA AGAGCAACCA GCAGAACCTG 
GGAACCATCA AATGCAGCAA CCTGTGCACA GAAATAGTGG AGTACACCAG CAAAGATGAG 
GTTGCTGTTT GTAATTTGGC TTCCCTGGCC CTGAATATGT ATGTCACATC AGAACACACA 
TACGACTTTA AGAAGTTGGC TGAAGTCACT AAAGTCGTTG TCCGAAACTT GAATAAAATT 
ATTGATATAA ACTACTATCC TGTACCAGAG GCATGCCTAT CAAATAAACG CCATCGCCCC 
ATTGGAATTG GGGTACAAGG TCTGGCAGAT GCTTTTATCC TGATGAGATA CCCTTTTGAG 
AGTGCAGAAG CCCAGTTACT GAATAAGCAG ATCTTTGAAA CTATTTATTA TGGTGCTCTG 
GAAGCCAGCT GTGACCTTGC CAAGGAGCAG GGCCCATACG AAACCTATGA GGGCTCTCCA 
GTTAGCAAAG GAATTCTTCA GTATGATATG TGGAATGTTA CTCCTACAGA CCTATGGGAC 
TGGAAGGTTC TCAAGGAGAA GATTGCAAAG TATGGTATAA GAAACAGTTT ACTTATTGCC 
CCGATGCCTA CAGCTTCCAC TGCTCAGATC CTGGGGAATA ATGAGTCCAT TGAACCTTAC 
ACCAGCAACA TCTATACTCG CAGAGTCTTG TCAGGAGAAT TTCAGATTGT AAATCCTCAC 
TTATTGAAAG ATCTTACCGA GCGGGGCCTA TGGCATGAAG AGATGAAAAA CCAGATTATT 
GCATGCAATG GCTCTATTCA GAGCATACCA GAAATTCCTG ATGACCTGAA GCAACTTTAT 
AAAACTGTGT GGGAAATCTC TCAGAAAACT GTTCTCAAGA TGGCAGCTGA GAGAGGTGCT 
TTCATTGATC AAAGCCAATC TTTGAACATC CACATTGCTG AGCCTAACTA TGGCAAACTC 
ACTAGTATGC ACTTCTACGG CTGGAAGCAG GGTTTGAAGA CTGGGATGTA TTATTTAAGG 
ACAAGACCAG CGGCTAATCC AATCCAGTTC ACTCTAAATA AGGAGAAGCT AAAAGATAAA 
GAAAAGGTAT CAAAAGAGGA AGAAGAGAAG GAGAGGAACA CAGCAGCCAT GGTGTGCTCT 
TTGGAGAATA GAGATGAATG TCTGATGTGT GGATCCTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RRM1 ( NM_001033.3 ) cDNA ORF clone, Homo sapiens(human) -> NP_001024.1 Homo sapiens ribonucleotide reductase M1 (RRM1), mRNA.

Price & Availability↑

CloneID	OHu19014
Clone ID Related Accession (Same CDS sequence)	NM_001033.4 , NM_001033.3 , NM_001033.5
Accession Version	NM_001033.3	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 2379bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2015-03-14
Organism	Homo sapiens(Human)
Product	ribonucleoside-diphosphate reductase large subunit
Comment

ATGCATGTGA TCAAGCGAGA TGGCCGCCAA GAACGAGTCA TGTTTGACAA AATTACATCT 
CGAATCCAGA AGCTTTGTTA TGGACTCAAT ATGGATTTTG TTGATCCTGC TCAGATCACC 
ATGAAAGTAA TCCAAGGCTT GTACAGTGGG GTCACCACAG TGGAACTAGA TACTTTGGCT 
GCTGAAACAG CTGCAACCTT GACTACTAAG CACCCTGACT ATGCTATCCT GGCAGCCAGG 
ATCGCTGTCT CTAACTTGCA CAAAGAAACA AAGAAAGTGT TCAGTGATGT GATGGAAGAC 
CTCTATAACT ACATAAATCC ACATAATGGC AAACACTCTC CCATGGTGGC CAAGTCAACA 
TTGGATATTG TTCTGGCCAA TAAAGATCGC CTGAATTCTG CTATTATCTA TGACCGAGAT 
TTCTCTTACA ATTACTTCGG CTTTAAGACG CTAGAGCGGT CTTATTTGTT GAAGATCAAT 
GGAAAAGTGG CTGAAAGACC ACAACATATG TTGATGAGAG TATCTGTTGG GATCCACAAA 
GAAGACATTG ATGCAGCAAT TGAAACATAT AATCTTCTTT CTGAGAGGTG GTTTACTCAT 
GCTTCGCCCA CTCTCTTCAA TGCTGGTACC AACCGCCCAC AACTTTCTAG CTGTTTTCTT 
CTGAGTATGA AAGATGACAG CATTGAAGGC ATTTATGACA CTCTAAAGCA ATGTGCATTG 
ATTTCTAAGT CTGCTGGAGG AATTGGTGTT GCTGTGAGTT GTATTCGGGC TACTGGCAGC 
TACATTGCTG GGACTAATGG CAATTCCAAT GGCCTTGTAC CGATGCTGAG AGTATATAAC 
AACACAGCTC GATATGTGGA TCAAGGTGGG AACAAGCGTC CTGGGGCATT TGCTATTTAC 
CTGGAGCCTT GGCATTTAGA CATCTTTGAA TTCCTTGATT TAAAGAAGAA CACAGGAAAG 
GAAGAGCAGC GTGCCAGAGA TCTTTTCTTT GCTCTTTGGA TTCCGGATCT CTTCATGAAA 
CGAGTGGAGA CTAATCAGGA CTGGTCTTTG ATGTGTCCAA ATGAGTGTCC TGGTCTGGAT 
GAGGTTTGGG GAGAGGAATT TGAGAAACTA TATGCAAGTT ATGAGAAACA AGGTCGTGTC 
CGCAAAGTTG TAAAAGCTCA GCAGCTTTGG TATGCCATCA TTGAGTCTCA GACGGAAACA 
GGCACCCCGT ATATGCTCTA CAAAGATTCC TGTAATCGAA AGAGCAACCA GCAGAACCTG 
GGAACCATCA AATGCAGCAA CCTGTGCACA GAAATAGTGG AGTACACCAG CAAAGATGAG 
GTTGCTGTTT GTAATTTGGC TTCCCTGGCC CTGAATATGT ATGTCACATC AGAACACACA 
TACGACTTTA AGAAGTTGGC TGAAGTCACT AAAGTCGTTG TCCGAAACTT GAATAAAATT 
ATTGATATAA ACTACTATCC TGTACCAGAG GCATGCCTAT CAAATAAACG CCATCGCCCC 
ATTGGAATTG GGGTACAAGG TCTGGCAGAT GCTTTTATCC TGATGAGATA CCCTTTTGAG 
AGTGCAGAAG CCCAGTTACT GAATAAGCAG ATCTTTGAAA CTATTTATTA TGGTGCTCTG 
GAAGCCAGCT GTGACCTTGC CAAGGAGCAG GGCCCATACG AAACCTATGA GGGCTCTCCA 
GTTAGCAAAG GAATTCTTCA GTATGATATG TGGAATGTTA CTCCTACAGA CCTATGGGAC 
TGGAAGGTTC TCAAGGAGAA GATTGCAAAG TATGGTATAA GAAACAGTTT ACTTATTGCC 
CCGATGCCTA CAGCTTCCAC TGCTCAGATC CTGGGGAATA ATGAGTCCAT TGAACCTTAC 
ACCAGCAACA TCTATACTCG CAGAGTCTTG TCAGGAGAAT TTCAGATTGT AAATCCTCAC 
TTATTGAAAG ATCTTACCGA GCGGGGCCTA TGGCATGAAG AGATGAAAAA CCAGATTATT 
GCATGCAATG GCTCTATTCA GAGCATACCA GAAATTCCTG ATGACCTGAA GCAACTTTAT 
AAAACTGTGT GGGAAATCTC TCAGAAAACT GTTCTCAAGA TGGCAGCTGA GAGAGGTGCT 
TTCATTGATC AAAGCCAATC TTTGAACATC CACATTGCTG AGCCTAACTA TGGCAAACTC 
ACTAGTATGC ACTTCTACGG CTGGAAGCAG GGTTTGAAGA CTGGGATGTA TTATTTAAGG 
ACAAGACCAG CGGCTAATCC AATCCAGTTC ACTCTAAATA AGGAGAAGCT AAAAGATAAA 
GAAAAGGTAT CAAAAGAGGA AGAAGAGAAG GAGAGGAACA CAGCAGCCAT GGTGTGCTCT 
TTGGAGAATA GAGATGAATG TCTGATGTGT GGATCCTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq

NP_001024.1

Translation

MHVIKRDGRQERVMFDKITSRIQKLCYGLNMDFVDPAQITMKVIQGLYSGVTTVELDTLAAETAATLTTKHPDYAILAARIAVSNLHKETKKVFSDVMEDLYNYINPHNGKHSPMVAKSTLDIVLANKDRLNSAIIYDRDFSYNYFGFKTLERSYLLKINGKVAERPQHMLMRVSVGIHKEDIDAAIETYNLLSERWFTHASPTLFNAGTNRPQLSSCFLLSMKDDSIEGIYDTLKQCALISKSAGGIGVAVSCIRATGSYIAGTNGNSNGLVPMLRVYNNTARYVDQGGNKRPGAFAIYLEPWHLDIFEFLDLKKNTGKEEQRARDLFFALWIPDLFMKRVETNQDWSLMCPNECPGLDEVWGEEFEKLYASYEKQGRVRKVVKAQQLWYAIIESQTETGTPYMLYKDSCNRKSNQQNLGTIKCSNLCTEIVEYTSKDEVAVCNLASLALNMYVTSEHTYDFKKLAEVTKVVVRNLNKIIDINYYPVPEACLSNKRHRPIGIGVQGLADAFILMRYPFESAEAQLLNKQIFETIYYGALEASCDLAKEQGPYETYEGSPVSKGILQYDMWNVTPTDLWDWKVLKEKIAKYGIRNSLLIAPMPTASTAQILGNNESIEPYTSNIYTRRVLSGEFQIVNPHLLKDLTERGLWHEEMKNQIIACNGSIQSIPEIPDDLKQLYKTVWEISQKTVLKMAAERGAFIDQSQSLNIHIAEPNYGKLTSMHFYGWKQGLKTGMYYLRTRPAANPIQFTLNKEKLKDKEKVSKEEEEKERNTAAMVCSLENRDECLMCGS

Target ORF information:

RefSeq Version	NM_001033.3
Organism	Homo sapiens(Human)
Definition	Homo sapiens ribonucleotide reductase M1 (RRM1), mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_001033.3

ORF Insert Sequence:

ATGCATGTGA TCAAGCGAGA TGGCCGCCAA GAACGAGTCA TGTTTGACAA AATTACATCT 
CGAATCCAGA AGCTTTGTTA TGGACTCAAT ATGGATTTTG TTGATCCTGC TCAGATCACC 
ATGAAAGTAA TCCAAGGCTT GTACAGTGGG GTCACCACAG TGGAACTAGA TACTTTGGCT 
GCTGAAACAG CTGCAACCTT GACTACTAAG CACCCTGACT ATGCTATCCT GGCAGCCAGG 
ATCGCTGTCT CTAACTTGCA CAAAGAAACA AAGAAAGTGT TCAGTGATGT GATGGAAGAC 
CTCTATAACT ACATAAATCC ACATAATGGC AAACACTCTC CCATGGTGGC CAAGTCAACA 
TTGGATATTG TTCTGGCCAA TAAAGATCGC CTGAATTCTG CTATTATCTA TGACCGAGAT 
TTCTCTTACA ATTACTTCGG CTTTAAGACG CTAGAGCGGT CTTATTTGTT GAAGATCAAT 
GGAAAAGTGG CTGAAAGACC ACAACATATG TTGATGAGAG TATCTGTTGG GATCCACAAA 
GAAGACATTG ATGCAGCAAT TGAAACATAT AATCTTCTTT CTGAGAGGTG GTTTACTCAT 
GCTTCGCCCA CTCTCTTCAA TGCTGGTACC AACCGCCCAC AACTTTCTAG CTGTTTTCTT 
CTGAGTATGA AAGATGACAG CATTGAAGGC ATTTATGACA CTCTAAAGCA ATGTGCATTG 
ATTTCTAAGT CTGCTGGAGG AATTGGTGTT GCTGTGAGTT GTATTCGGGC TACTGGCAGC 
TACATTGCTG GGACTAATGG CAATTCCAAT GGCCTTGTAC CGATGCTGAG AGTATATAAC 
AACACAGCTC GATATGTGGA TCAAGGTGGG AACAAGCGTC CTGGGGCATT TGCTATTTAC 
CTGGAGCCTT GGCATTTAGA CATCTTTGAA TTCCTTGATT TAAAGAAGAA CACAGGAAAG 
GAAGAGCAGC GTGCCAGAGA TCTTTTCTTT GCTCTTTGGA TTCCGGATCT CTTCATGAAA 
CGAGTGGAGA CTAATCAGGA CTGGTCTTTG ATGTGTCCAA ATGAGTGTCC TGGTCTGGAT 
GAGGTTTGGG GAGAGGAATT TGAGAAACTA TATGCAAGTT ATGAGAAACA AGGTCGTGTC 
CGCAAAGTTG TAAAAGCTCA GCAGCTTTGG TATGCCATCA TTGAGTCTCA GACGGAAACA 
GGCACCCCGT ATATGCTCTA CAAAGATTCC TGTAATCGAA AGAGCAACCA GCAGAACCTG 
GGAACCATCA AATGCAGCAA CCTGTGCACA GAAATAGTGG AGTACACCAG CAAAGATGAG 
GTTGCTGTTT GTAATTTGGC TTCCCTGGCC CTGAATATGT ATGTCACATC AGAACACACA 
TACGACTTTA AGAAGTTGGC TGAAGTCACT AAAGTCGTTG TCCGAAACTT GAATAAAATT 
ATTGATATAA ACTACTATCC TGTACCAGAG GCATGCCTAT CAAATAAACG CCATCGCCCC 
ATTGGAATTG GGGTACAAGG TCTGGCAGAT GCTTTTATCC TGATGAGATA CCCTTTTGAG 
AGTGCAGAAG CCCAGTTACT GAATAAGCAG ATCTTTGAAA CTATTTATTA TGGTGCTCTG 
GAAGCCAGCT GTGACCTTGC CAAGGAGCAG GGCCCATACG AAACCTATGA GGGCTCTCCA 
GTTAGCAAAG GAATTCTTCA GTATGATATG TGGAATGTTA CTCCTACAGA CCTATGGGAC 
TGGAAGGTTC TCAAGGAGAA GATTGCAAAG TATGGTATAA GAAACAGTTT ACTTATTGCC 
CCGATGCCTA CAGCTTCCAC TGCTCAGATC CTGGGGAATA ATGAGTCCAT TGAACCTTAC 
ACCAGCAACA TCTATACTCG CAGAGTCTTG TCAGGAGAAT TTCAGATTGT AAATCCTCAC 
TTATTGAAAG ATCTTACCGA GCGGGGCCTA TGGCATGAAG AGATGAAAAA CCAGATTATT 
GCATGCAATG GCTCTATTCA GAGCATACCA GAAATTCCTG ATGACCTGAA GCAACTTTAT 
AAAACTGTGT GGGAAATCTC TCAGAAAACT GTTCTCAAGA TGGCAGCTGA GAGAGGTGCT 
TTCATTGATC AAAGCCAATC TTTGAACATC CACATTGCTG AGCCTAACTA TGGCAAACTC 
ACTAGTATGC ACTTCTACGG CTGGAAGCAG GGTTTGAAGA CTGGGATGTA TTATTTAAGG 
ACAAGACCAG CGGCTAATCC AATCCAGTTC ACTCTAAATA AGGAGAAGCT AAAAGATAAA 
GAAAAGGTAT CAAAAGAGGA AGAAGAGAAG GAGAGGAACA CAGCAGCCAT GGTGTGCTCT 
TTGGAGAATA GAGATGAATG TCTGATGTGT GGATCCTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RRM1 ( NM_001033.5 ) cDNA ORF clone, Homo sapiens(human) -> NP_001024.1 Homo sapiens ribonucleotide reductase catalytic subunit M1 (RRM1), transcript variant 1, mRNA.

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CloneID	OHu19014
Clone ID Related Accession (Same CDS sequence)	NM_001033.4 , NM_001033.3 , NM_001033.5
Accession Version	NM_001033.5 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 2379bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-12-30
Organism	Homo sapiens(human)
Product	ribonucleoside-diphosphate reductase large subunit isoform 1
Comment	Comment: REVIEWED REFSEQ: This record has been curated by NCBI staff. The reference sequence was derived from BP229960.1, BC006498.2, X59617.1, BQ775841.1, CB853003.1 and AC015689.12. This sequence is a reference standard in the RefSeqGene project. On Nov 22, 2018 this sequence version replaced NM_001033.4. Transcript Variant: This variant (1) represents the longest transcript and encodes the longest isoform (1). Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: SRR1803612.250532.1, SRR1660803.164459.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA1965299, SAMEA1966682 [ECO:0000348] ##Evidence-Data-END## ##RefSeq-Attributes-START## MANE Ensembl match :: ENST00000300738.10/ ENSP00000300738.5 RefSeq Select criteria :: based on conservation, expression, longest protein ##RefSeq-Attributes-END## COMPLETENESS: full length.

ATGCATGTGA TCAAGCGAGA TGGCCGCCAA GAACGAGTCA TGTTTGACAA AATTACATCT 
CGAATCCAGA AGCTTTGTTA TGGACTCAAT ATGGATTTTG TTGATCCTGC TCAGATCACC 
ATGAAAGTAA TCCAAGGCTT GTACAGTGGG GTCACCACAG TGGAACTAGA TACTTTGGCT 
GCTGAAACAG CTGCAACCTT GACTACTAAG CACCCTGACT ATGCTATCCT GGCAGCCAGG 
ATCGCTGTCT CTAACTTGCA CAAAGAAACA AAGAAAGTGT TCAGTGATGT GATGGAAGAC 
CTCTATAACT ACATAAATCC ACATAATGGC AAACACTCTC CCATGGTGGC CAAGTCAACA 
TTGGATATTG TTCTGGCCAA TAAAGATCGC CTGAATTCTG CTATTATCTA TGACCGAGAT 
TTCTCTTACA ATTACTTCGG CTTTAAGACG CTAGAGCGGT CTTATTTGTT GAAGATCAAT 
GGAAAAGTGG CTGAAAGACC ACAACATATG TTGATGAGAG TATCTGTTGG GATCCACAAA 
GAAGACATTG ATGCAGCAAT TGAAACATAT AATCTTCTTT CTGAGAGGTG GTTTACTCAT 
GCTTCGCCCA CTCTCTTCAA TGCTGGTACC AACCGCCCAC AACTTTCTAG CTGTTTTCTT 
CTGAGTATGA AAGATGACAG CATTGAAGGC ATTTATGACA CTCTAAAGCA ATGTGCATTG 
ATTTCTAAGT CTGCTGGAGG AATTGGTGTT GCTGTGAGTT GTATTCGGGC TACTGGCAGC 
TACATTGCTG GGACTAATGG CAATTCCAAT GGCCTTGTAC CGATGCTGAG AGTATATAAC 
AACACAGCTC GATATGTGGA TCAAGGTGGG AACAAGCGTC CTGGGGCATT TGCTATTTAC 
CTGGAGCCTT GGCATTTAGA CATCTTTGAA TTCCTTGATT TAAAGAAGAA CACAGGAAAG 
GAAGAGCAGC GTGCCAGAGA TCTTTTCTTT GCTCTTTGGA TTCCGGATCT CTTCATGAAA 
CGAGTGGAGA CTAATCAGGA CTGGTCTTTG ATGTGTCCAA ATGAGTGTCC TGGTCTGGAT 
GAGGTTTGGG GAGAGGAATT TGAGAAACTA TATGCAAGTT ATGAGAAACA AGGTCGTGTC 
CGCAAAGTTG TAAAAGCTCA GCAGCTTTGG TATGCCATCA TTGAGTCTCA GACGGAAACA 
GGCACCCCGT ATATGCTCTA CAAAGATTCC TGTAATCGAA AGAGCAACCA GCAGAACCTG 
GGAACCATCA AATGCAGCAA CCTGTGCACA GAAATAGTGG AGTACACCAG CAAAGATGAG 
GTTGCTGTTT GTAATTTGGC TTCCCTGGCC CTGAATATGT ATGTCACATC AGAACACACA 
TACGACTTTA AGAAGTTGGC TGAAGTCACT AAAGTCGTTG TCCGAAACTT GAATAAAATT 
ATTGATATAA ACTACTATCC TGTACCAGAG GCATGCCTAT CAAATAAACG CCATCGCCCC 
ATTGGAATTG GGGTACAAGG TCTGGCAGAT GCTTTTATCC TGATGAGATA CCCTTTTGAG 
AGTGCAGAAG CCCAGTTACT GAATAAGCAG ATCTTTGAAA CTATTTATTA TGGTGCTCTG 
GAAGCCAGCT GTGACCTTGC CAAGGAGCAG GGCCCATACG AAACCTATGA GGGCTCTCCA 
GTTAGCAAAG GAATTCTTCA GTATGATATG TGGAATGTTA CTCCTACAGA CCTATGGGAC 
TGGAAGGTTC TCAAGGAGAA GATTGCAAAG TATGGTATAA GAAACAGTTT ACTTATTGCC 
CCGATGCCTA CAGCTTCCAC TGCTCAGATC CTGGGGAATA ATGAGTCCAT TGAACCTTAC 
ACCAGCAACA TCTATACTCG CAGAGTCTTG TCAGGAGAAT TTCAGATTGT AAATCCTCAC 
TTATTGAAAG ATCTTACCGA GCGGGGCCTA TGGCATGAAG AGATGAAAAA CCAGATTATT 
GCATGCAATG GCTCTATTCA GAGCATACCA GAAATTCCTG ATGACCTGAA GCAACTTTAT 
AAAACTGTGT GGGAAATCTC TCAGAAAACT GTTCTCAAGA TGGCAGCTGA GAGAGGTGCT 
TTCATTGATC AAAGCCAATC TTTGAACATC CACATTGCTG AGCCTAACTA TGGCAAACTC 
ACTAGTATGC ACTTCTACGG CTGGAAGCAG GGTTTGAAGA CTGGGATGTA TTATTTAAGG 
ACAAGACCAG CGGCTAATCC AATCCAGTTC ACTCTAAATA AGGAGAAGCT AAAAGATAAA 
GAAAAGGTAT CAAAAGAGGA AGAAGAGAAG GAGAGGAACA CAGCAGCCAT GGTGTGCTCT 
TTGGAGAATA GAGATGAATG TCTGATGTGT GGATCCTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_001024.1
CDS	215..2593
Translation	MHVIKRDGRQERVMFDKITSRIQKLCYGLNMDFVDPAQITMKVIQGLYSGVTTVELDTLAAETAATLTTKHPDYAILAARIAVSNLHKETKKVFSDVMEDLYNYINPHNGKHSPMVAKSTLDIVLANKDRLNSAIIYDRDFSYNYFGFKTLERSYLLKINGKVAERPQHMLMRVSVGIHKEDIDAAIETYNLLSERWFTHASPTLFNAGTNRPQLSSCFLLSMKDDSIEGIYDTLKQCALISKSAGGIGVAVSCIRATGSYIAGTNGNSNGLVPMLRVYNNTARYVDQGGNKRPGAFAIYLEPWHLDIFEFLDLKKNTGKEEQRARDLFFALWIPDLFMKRVETNQDWSLMCPNECPGLDEVWGEEFEKLYASYEKQGRVRKVVKAQQLWYAIIESQTETGTPYMLYKDSCNRKSNQQNLGTIKCSNLCTEIVEYTSKDEVAVCNLASLALNMYVTSEHTYDFKKLAEVTKVVVRNLNKIIDINYYPVPEACLSNKRHRPIGIGVQGLADAFILMRYPFESAEAQLLNKQIFETIYYGALEASCDLAKEQGPYETYEGSPVSKGILQYDMWNVTPTDLWDWKVLKEKIAKYGIRNSLLIAPMPTASTAQILGNNESIEPYTSNIYTRRVLSGEFQIVNPHLLKDLTERGLWHEEMKNQIIACNGSIQSIPEIPDDLKQLYKTVWEISQKTVLKMAAERGAFIDQSQSLNIHIAEPNYGKLTSMHFYGWKQGLKTGMYYLRTRPAANPIQFTLNKEKLKDKEKVSKEEEEKERNTAAMVCSLENRDECLMCGS

Target ORF information:

RefSeq Version	NM_001033.5
Organism	Homo sapiens(human)
Definition	Homo sapiens ribonucleotide reductase catalytic subunit M1 (RRM1), transcript variant 1, mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_001033.5

ORF Insert Sequence:

ATGCATGTGA TCAAGCGAGA TGGCCGCCAA GAACGAGTCA TGTTTGACAA AATTACATCT 
CGAATCCAGA AGCTTTGTTA TGGACTCAAT ATGGATTTTG TTGATCCTGC TCAGATCACC 
ATGAAAGTAA TCCAAGGCTT GTACAGTGGG GTCACCACAG TGGAACTAGA TACTTTGGCT 
GCTGAAACAG CTGCAACCTT GACTACTAAG CACCCTGACT ATGCTATCCT GGCAGCCAGG 
ATCGCTGTCT CTAACTTGCA CAAAGAAACA AAGAAAGTGT TCAGTGATGT GATGGAAGAC 
CTCTATAACT ACATAAATCC ACATAATGGC AAACACTCTC CCATGGTGGC CAAGTCAACA 
TTGGATATTG TTCTGGCCAA TAAAGATCGC CTGAATTCTG CTATTATCTA TGACCGAGAT 
TTCTCTTACA ATTACTTCGG CTTTAAGACG CTAGAGCGGT CTTATTTGTT GAAGATCAAT 
GGAAAAGTGG CTGAAAGACC ACAACATATG TTGATGAGAG TATCTGTTGG GATCCACAAA 
GAAGACATTG ATGCAGCAAT TGAAACATAT AATCTTCTTT CTGAGAGGTG GTTTACTCAT 
GCTTCGCCCA CTCTCTTCAA TGCTGGTACC AACCGCCCAC AACTTTCTAG CTGTTTTCTT 
CTGAGTATGA AAGATGACAG CATTGAAGGC ATTTATGACA CTCTAAAGCA ATGTGCATTG 
ATTTCTAAGT CTGCTGGAGG AATTGGTGTT GCTGTGAGTT GTATTCGGGC TACTGGCAGC 
TACATTGCTG GGACTAATGG CAATTCCAAT GGCCTTGTAC CGATGCTGAG AGTATATAAC 
AACACAGCTC GATATGTGGA TCAAGGTGGG AACAAGCGTC CTGGGGCATT TGCTATTTAC 
CTGGAGCCTT GGCATTTAGA CATCTTTGAA TTCCTTGATT TAAAGAAGAA CACAGGAAAG 
GAAGAGCAGC GTGCCAGAGA TCTTTTCTTT GCTCTTTGGA TTCCGGATCT CTTCATGAAA 
CGAGTGGAGA CTAATCAGGA CTGGTCTTTG ATGTGTCCAA ATGAGTGTCC TGGTCTGGAT 
GAGGTTTGGG GAGAGGAATT TGAGAAACTA TATGCAAGTT ATGAGAAACA AGGTCGTGTC 
CGCAAAGTTG TAAAAGCTCA GCAGCTTTGG TATGCCATCA TTGAGTCTCA GACGGAAACA 
GGCACCCCGT ATATGCTCTA CAAAGATTCC TGTAATCGAA AGAGCAACCA GCAGAACCTG 
GGAACCATCA AATGCAGCAA CCTGTGCACA GAAATAGTGG AGTACACCAG CAAAGATGAG 
GTTGCTGTTT GTAATTTGGC TTCCCTGGCC CTGAATATGT ATGTCACATC AGAACACACA 
TACGACTTTA AGAAGTTGGC TGAAGTCACT AAAGTCGTTG TCCGAAACTT GAATAAAATT 
ATTGATATAA ACTACTATCC TGTACCAGAG GCATGCCTAT CAAATAAACG CCATCGCCCC 
ATTGGAATTG GGGTACAAGG TCTGGCAGAT GCTTTTATCC TGATGAGATA CCCTTTTGAG 
AGTGCAGAAG CCCAGTTACT GAATAAGCAG ATCTTTGAAA CTATTTATTA TGGTGCTCTG 
GAAGCCAGCT GTGACCTTGC CAAGGAGCAG GGCCCATACG AAACCTATGA GGGCTCTCCA 
GTTAGCAAAG GAATTCTTCA GTATGATATG TGGAATGTTA CTCCTACAGA CCTATGGGAC 
TGGAAGGTTC TCAAGGAGAA GATTGCAAAG TATGGTATAA GAAACAGTTT ACTTATTGCC 
CCGATGCCTA CAGCTTCCAC TGCTCAGATC CTGGGGAATA ATGAGTCCAT TGAACCTTAC 
ACCAGCAACA TCTATACTCG CAGAGTCTTG TCAGGAGAAT TTCAGATTGT AAATCCTCAC 
TTATTGAAAG ATCTTACCGA GCGGGGCCTA TGGCATGAAG AGATGAAAAA CCAGATTATT 
GCATGCAATG GCTCTATTCA GAGCATACCA GAAATTCCTG ATGACCTGAA GCAACTTTAT 
AAAACTGTGT GGGAAATCTC TCAGAAAACT GTTCTCAAGA TGGCAGCTGA GAGAGGTGCT 
TTCATTGATC AAAGCCAATC TTTGAACATC CACATTGCTG AGCCTAACTA TGGCAAACTC 
ACTAGTATGC ACTTCTACGG CTGGAAGCAG GGTTTGAAGA CTGGGATGTA TTATTTAAGG 
ACAAGACCAG CGGCTAATCC AATCCAGTTC ACTCTAAATA AGGAGAAGCT AAAAGATAAA 
GAAAAGGTAT CAAAAGAGGA AGAAGAGAAG GAGAGGAACA CAGCAGCCAT GGTGTGCTCT 
TTGGAGAATA GAGATGAATG TCTGATGTGT GGATCCTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RRM1 ( NM_001318064.1 ) cDNA ORF clone, Homo sapiens(human) -> NP_001304993.1 Homo sapiens ribonucleotide reductase catalytic subunit M1 (RRM1), transcript variant 2, mRNA.

Price & Availability↑

CloneID	OHu60335
Clone ID Related Accession (Same CDS sequence)	NM_001318064.1
Accession Version	NM_001318064.1 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 2088bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-12-28
Organism	Homo sapiens(human)
Product	ribonucleoside-diphosphate reductase large subunit isoform 2
Comment	Comment: REVIEWED REFSEQ: This record has been curated by NCBI staff. The reference sequence was derived from AC015689.12, BP229960.1, AK303394.1, X59617.1, BQ775841.1 and CB853003.1. On Dec 22, 2015 this sequence version replaced XM_011520277.1. Transcript Variant: This variant (2) differs in the 5' UTR, lacks a portion of the 5' coding region, and uses a downstream translation start site compared to variant 1. The encoded isoform (2) has a shorter N-terminus compared to isoform 1. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: SRR1803614.215727.1, AK303394.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA1965299, SAMEA1966682 [ECO:0000348] ##Evidence-Data-END## COMPLETENESS: complete on the 3' end.

ATGGAAGACC TCTATAACTA CATAAATCCA CATAATGGCA AACACTCTCC CATGGTGGCC 
AAGTCAACAT TGGATATTGT TCTGGCCAAT AAAGATCGCC TGAATTCTGC TATTATCTAT 
GACCGAGATT TCTCTTACAA TTACTTCGGC TTTAAGACGC TAGAGCGGTC TTATTTGTTG 
AAGATCAATG GAAAAGTGGC TGAAAGACCA CAACATATGT TGATGAGAGT ATCTGTTGGG 
ATCCACAAAG AAGACATTGA TGCAGCAATT GAAACATATA ATCTTCTTTC TGAGAGGTGG 
TTTACTCATG CTTCGCCCAC TCTCTTCAAT GCTGGTACCA ACCGCCCACA ACTTTCTAGC 
TGTTTTCTTC TGAGTATGAA AGATGACAGC ATTGAAGGCA TTTATGACAC TCTAAAGCAA 
TGTGCATTGA TTTCTAAGTC TGCTGGAGGA ATTGGTGTTG CTGTGAGTTG TATTCGGGCT 
ACTGGCAGCT ACATTGCTGG GACTAATGGC AATTCCAATG GCCTTGTACC GATGCTGAGA 
GTATATAACA ACACAGCTCG ATATGTGGAT CAAGGTGGGA ACAAGCGTCC TGGGGCATTT 
GCTATTTACC TGGAGCCTTG GCATTTAGAC ATCTTTGAAT TCCTTGATTT AAAGAAGAAC 
ACAGGAAAGG AAGAGCAGCG TGCCAGAGAT CTTTTCTTTG CTCTTTGGAT TCCGGATCTC 
TTCATGAAAC GAGTGGAGAC TAATCAGGAC TGGTCTTTGA TGTGTCCAAA TGAGTGTCCT 
GGTCTGGATG AGGTTTGGGG AGAGGAATTT GAGAAACTAT ATGCAAGTTA TGAGAAACAA 
GGTCGTGTCC GCAAAGTTGT AAAAGCTCAG CAGCTTTGGT ATGCCATCAT TGAGTCTCAG 
ACGGAAACAG GCACCCCGTA TATGCTCTAC AAAGATTCCT GTAATCGAAA GAGCAACCAG 
CAGAACCTGG GAACCATCAA ATGCAGCAAC CTGTGCACAG AAATAGTGGA GTACACCAGC 
AAAGATGAGG TTGCTGTTTG TAATTTGGCT TCCCTGGCCC TGAATATGTA TGTCACATCA 
GAACACACAT ACGACTTTAA GAAGTTGGCT GAAGTCACTA AAGTCGTTGT CCGAAACTTG 
AATAAAATTA TTGATATAAA CTACTATCCT GTACCAGAGG CATGCCTATC AAATAAACGC 
CATCGCCCCA TTGGAATTGG GGTACAAGGT CTGGCAGATG CTTTTATCCT GATGAGATAC 
CCTTTTGAGA GTGCAGAAGC CCAGTTACTG AATAAGCAGA TCTTTGAAAC TATTTATTAT 
GGTGCTCTGG AAGCCAGCTG TGACCTTGCC AAGGAGCAGG GCCCATACGA AACCTATGAG 
GGCTCTCCAG TTAGCAAAGG AATTCTTCAG TATGATATGT GGAATGTTAC TCCTACAGAC 
CTATGGGACT GGAAGGTTCT CAAGGAGAAG ATTGCAAAGT ATGGTATAAG AAACAGTTTA 
CTTATTGCCC CGATGCCTAC AGCTTCCACT GCTCAGATCC TGGGGAATAA TGAGTCCATT 
GAACCTTACA CCAGCAACAT CTATACTCGC AGAGTCTTGT CAGGAGAATT TCAGATTGTA 
AATCCTCACT TATTGAAAGA TCTTACCGAG CGGGGCCTAT GGCATGAAGA GATGAAAAAC 
CAGATTATTG CATGCAATGG CTCTATTCAG AGCATACCAG AAATTCCTGA TGACCTGAAG 
CAACTTTATA AAACTGTGTG GGAAATCTCT CAGAAAACTG TTCTCAAGAT GGCAGCTGAG 
AGAGGTGCTT TCATTGATCA AAGCCAATCT TTGAACATCC ACATTGCTGA GCCTAACTAT 
GGCAAACTCA CTAGTATGCA CTTCTACGGC TGGAAGCAGG GTTTGAAGAC TGGGATGTAT 
TATTTAAGGA CAAGACCAGC GGCTAATCCA ATCCAGTTCA CTCTAAATAA GGAGAAGCTA 
AAAGATAAAG AAAAGGTATC AAAAGAGGAA GAAGAGAAGG AGAGGAACAC AGCAGCCATG 
GTGTGCTCTT TGGAGAATAG AGATGAATGT CTGATGTGTG GATCCTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_001304993.1
CDS	442..2529
Translation	MEDLYNYINPHNGKHSPMVAKSTLDIVLANKDRLNSAIIYDRDFSYNYFGFKTLERSYLLKINGKVAERPQHMLMRVSVGIHKEDIDAAIETYNLLSERWFTHASPTLFNAGTNRPQLSSCFLLSMKDDSIEGIYDTLKQCALISKSAGGIGVAVSCIRATGSYIAGTNGNSNGLVPMLRVYNNTARYVDQGGNKRPGAFAIYLEPWHLDIFEFLDLKKNTGKEEQRARDLFFALWIPDLFMKRVETNQDWSLMCPNECPGLDEVWGEEFEKLYASYEKQGRVRKVVKAQQLWYAIIESQTETGTPYMLYKDSCNRKSNQQNLGTIKCSNLCTEIVEYTSKDEVAVCNLASLALNMYVTSEHTYDFKKLAEVTKVVVRNLNKIIDINYYPVPEACLSNKRHRPIGIGVQGLADAFILMRYPFESAEAQLLNKQIFETIYYGALEASCDLAKEQGPYETYEGSPVSKGILQYDMWNVTPTDLWDWKVLKEKIAKYGIRNSLLIAPMPTASTAQILGNNESIEPYTSNIYTRRVLSGEFQIVNPHLLKDLTERGLWHEEMKNQIIACNGSIQSIPEIPDDLKQLYKTVWEISQKTVLKMAAERGAFIDQSQSLNIHIAEPNYGKLTSMHFYGWKQGLKTGMYYLRTRPAANPIQFTLNKEKLKDKEKVSKEEEEKERNTAAMVCSLENRDECLMCGS

Target ORF information:

RefSeq Version	NM_001318064.1
Organism	Homo sapiens(human)
Definition	Homo sapiens ribonucleotide reductase catalytic subunit M1 (RRM1), transcript variant 2, mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_001318064.1

ORF Insert Sequence:

ATGGAAGACC TCTATAACTA CATAAATCCA CATAATGGCA AACACTCTCC CATGGTGGCC 
AAGTCAACAT TGGATATTGT TCTGGCCAAT AAAGATCGCC TGAATTCTGC TATTATCTAT 
GACCGAGATT TCTCTTACAA TTACTTCGGC TTTAAGACGC TAGAGCGGTC TTATTTGTTG 
AAGATCAATG GAAAAGTGGC TGAAAGACCA CAACATATGT TGATGAGAGT ATCTGTTGGG 
ATCCACAAAG AAGACATTGA TGCAGCAATT GAAACATATA ATCTTCTTTC TGAGAGGTGG 
TTTACTCATG CTTCGCCCAC TCTCTTCAAT GCTGGTACCA ACCGCCCACA ACTTTCTAGC 
TGTTTTCTTC TGAGTATGAA AGATGACAGC ATTGAAGGCA TTTATGACAC TCTAAAGCAA 
TGTGCATTGA TTTCTAAGTC TGCTGGAGGA ATTGGTGTTG CTGTGAGTTG TATTCGGGCT 
ACTGGCAGCT ACATTGCTGG GACTAATGGC AATTCCAATG GCCTTGTACC GATGCTGAGA 
GTATATAACA ACACAGCTCG ATATGTGGAT CAAGGTGGGA ACAAGCGTCC TGGGGCATTT 
GCTATTTACC TGGAGCCTTG GCATTTAGAC ATCTTTGAAT TCCTTGATTT AAAGAAGAAC 
ACAGGAAAGG AAGAGCAGCG TGCCAGAGAT CTTTTCTTTG CTCTTTGGAT TCCGGATCTC 
TTCATGAAAC GAGTGGAGAC TAATCAGGAC TGGTCTTTGA TGTGTCCAAA TGAGTGTCCT 
GGTCTGGATG AGGTTTGGGG AGAGGAATTT GAGAAACTAT ATGCAAGTTA TGAGAAACAA 
GGTCGTGTCC GCAAAGTTGT AAAAGCTCAG CAGCTTTGGT ATGCCATCAT TGAGTCTCAG 
ACGGAAACAG GCACCCCGTA TATGCTCTAC AAAGATTCCT GTAATCGAAA GAGCAACCAG 
CAGAACCTGG GAACCATCAA ATGCAGCAAC CTGTGCACAG AAATAGTGGA GTACACCAGC 
AAAGATGAGG TTGCTGTTTG TAATTTGGCT TCCCTGGCCC TGAATATGTA TGTCACATCA 
GAACACACAT ACGACTTTAA GAAGTTGGCT GAAGTCACTA AAGTCGTTGT CCGAAACTTG 
AATAAAATTA TTGATATAAA CTACTATCCT GTACCAGAGG CATGCCTATC AAATAAACGC 
CATCGCCCCA TTGGAATTGG GGTACAAGGT CTGGCAGATG CTTTTATCCT GATGAGATAC 
CCTTTTGAGA GTGCAGAAGC CCAGTTACTG AATAAGCAGA TCTTTGAAAC TATTTATTAT 
GGTGCTCTGG AAGCCAGCTG TGACCTTGCC AAGGAGCAGG GCCCATACGA AACCTATGAG 
GGCTCTCCAG TTAGCAAAGG AATTCTTCAG TATGATATGT GGAATGTTAC TCCTACAGAC 
CTATGGGACT GGAAGGTTCT CAAGGAGAAG ATTGCAAAGT ATGGTATAAG AAACAGTTTA 
CTTATTGCCC CGATGCCTAC AGCTTCCACT GCTCAGATCC TGGGGAATAA TGAGTCCATT 
GAACCTTACA CCAGCAACAT CTATACTCGC AGAGTCTTGT CAGGAGAATT TCAGATTGTA 
AATCCTCACT TATTGAAAGA TCTTACCGAG CGGGGCCTAT GGCATGAAGA GATGAAAAAC 
CAGATTATTG CATGCAATGG CTCTATTCAG AGCATACCAG AAATTCCTGA TGACCTGAAG 
CAACTTTATA AAACTGTGTG GGAAATCTCT CAGAAAACTG TTCTCAAGAT GGCAGCTGAG 
AGAGGTGCTT TCATTGATCA AAGCCAATCT TTGAACATCC ACATTGCTGA GCCTAACTAT 
GGCAAACTCA CTAGTATGCA CTTCTACGGC TGGAAGCAGG GTTTGAAGAC TGGGATGTAT 
TATTTAAGGA CAAGACCAGC GGCTAATCCA ATCCAGTTCA CTCTAAATAA GGAGAAGCTA 
AAAGATAAAG AAAAGGTATC AAAAGAGGAA GAAGAGAAGG AGAGGAACAC AGCAGCCATG 
GTGTGCTCTT TGGAGAATAG AGATGAATGT CTGATGTGTG GATCCTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RRM1 ( NM_001330193.1 ) cDNA ORF clone, Homo sapiens(human) -> NP_001317122.1 Homo sapiens ribonucleotide reductase catalytic subunit M1 (RRM1), transcript variant 4, mRNA.

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CloneID	OHu60336
Clone ID Related Accession (Same CDS sequence)	NM_001330193.1
Accession Version	NM_001330193.1 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 1713bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-12-28
Organism	Homo sapiens(human)
Product	ribonucleoside-diphosphate reductase large subunit isoform 4
Comment	Comment: REVIEWED REFSEQ: This record has been curated by NCBI staff. The reference sequence was derived from AK311593.1, AC015689.12, BM464333.1 and BF681281.1. On Aug 20, 2016 this sequence version replaced XM_011520278.1. Transcript Variant: This variant (4) contains an alternate exon in the 5' UTR, lacks a portion of the 5' coding region, and initiates translation at a downstream start codon compared to variant 1. The encoded isoform (4) has a shorter N-terminus than isoform 1. Sequence Note: This RefSeq record was created from transcript and genomic sequence data to make the sequence consistent with the reference genome assembly. The genomic coordinates used for the transcript record were based on transcript alignments. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: SRR5189667.202659.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA1968968, SAMEA2148093 [ECO:0000348] ##Evidence-Data-END## COMPLETENESS: complete on the 3' end.

ATGAAAGATG ACAGCATTGA AGGCATTTAT GACACTCTAA AGCAATGTGC ATTGATTTCT 
AAGTCTGCTG GAGGAATTGG TGTTGCTGTG AGTTGTATTC GGGCTACTGG CAGCTACATT 
GCTGGGACTA ATGGCAATTC CAATGGCCTT GTACCGATGC TGAGAGTATA TAACAACACA 
GCTCGATATG TGGATCAAGG TGGGAACAAG CGTCCTGGGG CATTTGCTAT TTACCTGGAG 
CCTTGGCATT TAGACATCTT TGAATTCCTT GATTTAAAGA AGAACACAGG AAAGGAAGAG 
CAGCGTGCCA GAGATCTTTT CTTTGCTCTT TGGATTCCGG ATCTCTTCAT GAAACGAGTG 
GAGACTAATC AGGACTGGTC TTTGATGTGT CCAAATGAGT GTCCTGGTCT GGATGAGGTT 
TGGGGAGAGG AATTTGAGAA ACTATATGCA AGTTATGAGA AACAAGGTCG TGTCCGCAAA 
GTTGTAAAAG CTCAGCAGCT TTGGTATGCC ATCATTGAGT CTCAGACGGA AACAGGCACC 
CCGTATATGC TCTACAAAGA TTCCTGTAAT CGAAAGAGCA ACCAGCAGAA CCTGGGAACC 
ATCAAATGCA GCAACCTGTG CACAGAAATA GTGGAGTACA CCAGCAAAGA TGAGGTTGCT 
GTTTGTAATT TGGCTTCCCT GGCCCTGAAT ATGTATGTCA CATCAGAACA CACATACGAC 
TTTAAGAAGT TGGCTGAAGT CACTAAAGTC GTTGTCCGAA ACTTGAATAA AATTATTGAT 
ATAAACTACT ATCCTGTACC AGAGGCATGC CTATCAAATA AACGCCATCG CCCCATTGGA 
ATTGGGGTAC AAGGTCTGGC AGATGCTTTT ATCCTGATGA GATACCCTTT TGAGAGTGCA 
GAAGCCCAGT TACTGAATAA GCAGATCTTT GAAACTATTT ATTATGGTGC TCTGGAAGCC 
AGCTGTGACC TTGCCAAGGA GCAGGGCCCA TACGAAACCT ATGAGGGCTC TCCAGTTAGC 
AAAGGAATTC TTCAGTATGA TATGTGGAAT GTTACTCCTA CAGACCTATG GGACTGGAAG 
GTTCTCAAGG AGAAGATTGC AAAGTATGGT ATAAGAAACA GTTTACTTAT TGCCCCGATG 
CCTACAGCTT CCACTGCTCA GATCCTGGGG AATAATGAGT CCATTGAACC TTACACCAGC 
AACATCTATA CTCGCAGAGT CTTGTCAGGA GAATTTCAGA TTGTAAATCC TCACTTATTG 
AAAGATCTTA CCGAGCGGGG CCTATGGCAT GAAGAGATGA AAAACCAGAT TATTGCATGC 
AATGGCTCTA TTCAGAGCAT ACCAGAAATT CCTGATGACC TGAAGCAACT TTATAAAACT 
GTGTGGGAAA TCTCTCAGAA AACTGTTCTC AAGATGGCAG CTGAGAGAGG TGCTTTCATT 
GATCAAAGCC AATCTTTGAA CATCCACATT GCTGAGCCTA ACTATGGCAA ACTCACTAGT 
ATGCACTTCT ACGGCTGGAA GCAGGGTTTG AAGACTGGGA TGTATTATTT AAGGACAAGA 
CCAGCGGCTA ATCCAATCCA GTTCACTCTA AATAAGGAGA AGCTAAAAGA TAAAGAAAAG 
GTATCAAAAG AGGAAGAAGA GAAGGAGAGG AACACAGCAG CCATGGTGTG CTCTTTGGAG 
AATAGAGATG AATGTCTGAT GTGTGGATCC TGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_001317122.1
CDS	300..2012
Translation	MKDDSIEGIYDTLKQCALISKSAGGIGVAVSCIRATGSYIAGTNGNSNGLVPMLRVYNNTARYVDQGGNKRPGAFAIYLEPWHLDIFEFLDLKKNTGKEEQRARDLFFALWIPDLFMKRVETNQDWSLMCPNECPGLDEVWGEEFEKLYASYEKQGRVRKVVKAQQLWYAIIESQTETGTPYMLYKDSCNRKSNQQNLGTIKCSNLCTEIVEYTSKDEVAVCNLASLALNMYVTSEHTYDFKKLAEVTKVVVRNLNKIIDINYYPVPEACLSNKRHRPIGIGVQGLADAFILMRYPFESAEAQLLNKQIFETIYYGALEASCDLAKEQGPYETYEGSPVSKGILQYDMWNVTPTDLWDWKVLKEKIAKYGIRNSLLIAPMPTASTAQILGNNESIEPYTSNIYTRRVLSGEFQIVNPHLLKDLTERGLWHEEMKNQIIACNGSIQSIPEIPDDLKQLYKTVWEISQKTVLKMAAERGAFIDQSQSLNIHIAEPNYGKLTSMHFYGWKQGLKTGMYYLRTRPAANPIQFTLNKEKLKDKEKVSKEEEEKERNTAAMVCSLENRDECLMCGS

Target ORF information:

RefSeq Version	NM_001330193.1
Organism	Homo sapiens(human)
Definition	Homo sapiens ribonucleotide reductase catalytic subunit M1 (RRM1), transcript variant 4, mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_001330193.1

ORF Insert Sequence:

ATGAAAGATG ACAGCATTGA AGGCATTTAT GACACTCTAA AGCAATGTGC ATTGATTTCT 
AAGTCTGCTG GAGGAATTGG TGTTGCTGTG AGTTGTATTC GGGCTACTGG CAGCTACATT 
GCTGGGACTA ATGGCAATTC CAATGGCCTT GTACCGATGC TGAGAGTATA TAACAACACA 
GCTCGATATG TGGATCAAGG TGGGAACAAG CGTCCTGGGG CATTTGCTAT TTACCTGGAG 
CCTTGGCATT TAGACATCTT TGAATTCCTT GATTTAAAGA AGAACACAGG AAAGGAAGAG 
CAGCGTGCCA GAGATCTTTT CTTTGCTCTT TGGATTCCGG ATCTCTTCAT GAAACGAGTG 
GAGACTAATC AGGACTGGTC TTTGATGTGT CCAAATGAGT GTCCTGGTCT GGATGAGGTT 
TGGGGAGAGG AATTTGAGAA ACTATATGCA AGTTATGAGA AACAAGGTCG TGTCCGCAAA 
GTTGTAAAAG CTCAGCAGCT TTGGTATGCC ATCATTGAGT CTCAGACGGA AACAGGCACC 
CCGTATATGC TCTACAAAGA TTCCTGTAAT CGAAAGAGCA ACCAGCAGAA CCTGGGAACC 
ATCAAATGCA GCAACCTGTG CACAGAAATA GTGGAGTACA CCAGCAAAGA TGAGGTTGCT 
GTTTGTAATT TGGCTTCCCT GGCCCTGAAT ATGTATGTCA CATCAGAACA CACATACGAC 
TTTAAGAAGT TGGCTGAAGT CACTAAAGTC GTTGTCCGAA ACTTGAATAA AATTATTGAT 
ATAAACTACT ATCCTGTACC AGAGGCATGC CTATCAAATA AACGCCATCG CCCCATTGGA 
ATTGGGGTAC AAGGTCTGGC AGATGCTTTT ATCCTGATGA GATACCCTTT TGAGAGTGCA 
GAAGCCCAGT TACTGAATAA GCAGATCTTT GAAACTATTT ATTATGGTGC TCTGGAAGCC 
AGCTGTGACC TTGCCAAGGA GCAGGGCCCA TACGAAACCT ATGAGGGCTC TCCAGTTAGC 
AAAGGAATTC TTCAGTATGA TATGTGGAAT GTTACTCCTA CAGACCTATG GGACTGGAAG 
GTTCTCAAGG AGAAGATTGC AAAGTATGGT ATAAGAAACA GTTTACTTAT TGCCCCGATG 
CCTACAGCTT CCACTGCTCA GATCCTGGGG AATAATGAGT CCATTGAACC TTACACCAGC 
AACATCTATA CTCGCAGAGT CTTGTCAGGA GAATTTCAGA TTGTAAATCC TCACTTATTG 
AAAGATCTTA CCGAGCGGGG CCTATGGCAT GAAGAGATGA AAAACCAGAT TATTGCATGC 
AATGGCTCTA TTCAGAGCAT ACCAGAAATT CCTGATGACC TGAAGCAACT TTATAAAACT 
GTGTGGGAAA TCTCTCAGAA AACTGTTCTC AAGATGGCAG CTGAGAGAGG TGCTTTCATT 
GATCAAAGCC AATCTTTGAA CATCCACATT GCTGAGCCTA ACTATGGCAA ACTCACTAGT 
ATGCACTTCT ACGGCTGGAA GCAGGGTTTG AAGACTGGGA TGTATTATTT AAGGACAAGA 
CCAGCGGCTA ATCCAATCCA GTTCACTCTA AATAAGGAGA AGCTAAAAGA TAAAGAAAAG 
GTATCAAAAG AGGAAGAAGA GAAGGAGAGG AACACAGCAG CCATGGTGTG CTCTTTGGAG 
AATAGAGATG AATGTCTGAT GTGTGGATCC TGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RRM1 ( NM_001318065.1 ) cDNA ORF clone, Homo sapiens(human) -> NP_001304994.1 Homo sapiens ribonucleotide reductase catalytic subunit M1 (RRM1), transcript variant 3, mRNA.

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CloneID	OHu60337
Clone ID Related Accession (Same CDS sequence)	NM_001318065.1
Accession Version	NM_001318065.1 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 1365bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-12-28
Organism	Homo sapiens(human)
Product	ribonucleoside-diphosphate reductase large subunit isoform 3
Comment	Comment: REVIEWED REFSEQ: This record has been curated by NCBI staff. The reference sequence was derived from AK311593.1, AC015689.12, AK301922.1, BQ775841.1, BC006498.2 and CB853003.1. On Dec 22, 2015 this sequence version replaced XM_011520279.1. Transcript Variant: This variant (3) represents use of an alternate promoter and therefore differs in the 5' UTR and 5' coding region, and uses a downstream translation start site compared to variant 1. The encoded isoform (3) has a shorter N-terminus compared to isoform 1. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: AK301922.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA1968968, SAMEA2148093 [ECO:0000348] ##Evidence-Data-END## COMPLETENESS: complete on the 3' end.

ATGAAACGAG TGGAGACTAA TCAGGACTGG TCTTTGATGT GTCCAAATGA GTGTCCTGGT 
CTGGATGAGG TTTGGGGAGA GGAATTTGAG AAACTATATG CAAGTTATGA GAAACAAGGT 
CGTGTCCGCA AAGTTGTAAA AGCTCAGCAG CTTTGGTATG CCATCATTGA GTCTCAGACG 
GAAACAGGCA CCCCGTATAT GCTCTACAAA GATTCCTGTA ATCGAAAGAG CAACCAGCAG 
AACCTGGGAA CCATCAAATG CAGCAACCTG TGCACAGAAA TAGTGGAGTA CACCAGCAAA 
GATGAGGTTG CTGTTTGTAA TTTGGCTTCC CTGGCCCTGA ATATGTATGT CACATCAGAA 
CACACATACG ACTTTAAGAA GTTGGCTGAA GTCACTAAAG TCGTTGTCCG AAACTTGAAT 
AAAATTATTG ATATAAACTA CTATCCTGTA CCAGAGGCAT GCCTATCAAA TAAACGCCAT 
CGCCCCATTG GAATTGGGGT ACAAGGTCTG GCAGATGCTT TTATCCTGAT GAGATACCCT 
TTTGAGAGTG CAGAAGCCCA GTTACTGAAT AAGCAGATCT TTGAAACTAT TTATTATGGT 
GCTCTGGAAG CCAGCTGTGA CCTTGCCAAG GAGCAGGGCC CATACGAAAC CTATGAGGGC 
TCTCCAGTTA GCAAAGGAAT TCTTCAGTAT GATATGTGGA ATGTTACTCC TACAGACCTA 
TGGGACTGGA AGGTTCTCAA GGAGAAGATT GCAAAGTATG GTATAAGAAA CAGTTTACTT 
ATTGCCCCGA TGCCTACAGC TTCCACTGCT CAGATCCTGG GGAATAATGA GTCCATTGAA 
CCTTACACCA GCAACATCTA TACTCGCAGA GTCTTGTCAG GAGAATTTCA GATTGTAAAT 
CCTCACTTAT TGAAAGATCT TACCGAGCGG GGCCTATGGC ATGAAGAGAT GAAAAACCAG 
ATTATTGCAT GCAATGGCTC TATTCAGAGC ATACCAGAAA TTCCTGATGA CCTGAAGCAA 
CTTTATAAAA CTGTGTGGGA AATCTCTCAG AAAACTGTTC TCAAGATGGC AGCTGAGAGA 
GGTGCTTTCA TTGATCAAAG CCAATCTTTG AACATCCACA TTGCTGAGCC TAACTATGGC 
AAACTCACTA GTATGCACTT CTACGGCTGG AAGCAGGGTT TGAAGACTGG GATGTATTAT 
TTAAGGACAA GACCAGCGGC TAATCCAATC CAGTTCACTC TAAATAAGGA GAAGCTAAAA 
GATAAAGAAA AGGTATCAAA AGAGGAAGAA GAGAAGGAGA GGAACACAGC AGCCATGGTG 
TGCTCTTTGG AGAATAGAGA TGAATGTCTG ATGTGTGGAT CCTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_001304994.1
CDS	690..2054
Translation	MKRVETNQDWSLMCPNECPGLDEVWGEEFEKLYASYEKQGRVRKVVKAQQLWYAIIESQTETGTPYMLYKDSCNRKSNQQNLGTIKCSNLCTEIVEYTSKDEVAVCNLASLALNMYVTSEHTYDFKKLAEVTKVVVRNLNKIIDINYYPVPEACLSNKRHRPIGIGVQGLADAFILMRYPFESAEAQLLNKQIFETIYYGALEASCDLAKEQGPYETYEGSPVSKGILQYDMWNVTPTDLWDWKVLKEKIAKYGIRNSLLIAPMPTASTAQILGNNESIEPYTSNIYTRRVLSGEFQIVNPHLLKDLTERGLWHEEMKNQIIACNGSIQSIPEIPDDLKQLYKTVWEISQKTVLKMAAERGAFIDQSQSLNIHIAEPNYGKLTSMHFYGWKQGLKTGMYYLRTRPAANPIQFTLNKEKLKDKEKVSKEEEEKERNTAAMVCSLENRDECLMCGS

Target ORF information:

RefSeq Version	NM_001318065.1
Organism	Homo sapiens(human)
Definition	Homo sapiens ribonucleotide reductase catalytic subunit M1 (RRM1), transcript variant 3, mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_001318065.1

ORF Insert Sequence:

ATGAAACGAG TGGAGACTAA TCAGGACTGG TCTTTGATGT GTCCAAATGA GTGTCCTGGT 
CTGGATGAGG TTTGGGGAGA GGAATTTGAG AAACTATATG CAAGTTATGA GAAACAAGGT 
CGTGTCCGCA AAGTTGTAAA AGCTCAGCAG CTTTGGTATG CCATCATTGA GTCTCAGACG 
GAAACAGGCA CCCCGTATAT GCTCTACAAA GATTCCTGTA ATCGAAAGAG CAACCAGCAG 
AACCTGGGAA CCATCAAATG CAGCAACCTG TGCACAGAAA TAGTGGAGTA CACCAGCAAA 
GATGAGGTTG CTGTTTGTAA TTTGGCTTCC CTGGCCCTGA ATATGTATGT CACATCAGAA 
CACACATACG ACTTTAAGAA GTTGGCTGAA GTCACTAAAG TCGTTGTCCG AAACTTGAAT 
AAAATTATTG ATATAAACTA CTATCCTGTA CCAGAGGCAT GCCTATCAAA TAAACGCCAT 
CGCCCCATTG GAATTGGGGT ACAAGGTCTG GCAGATGCTT TTATCCTGAT GAGATACCCT 
TTTGAGAGTG CAGAAGCCCA GTTACTGAAT AAGCAGATCT TTGAAACTAT TTATTATGGT 
GCTCTGGAAG CCAGCTGTGA CCTTGCCAAG GAGCAGGGCC CATACGAAAC CTATGAGGGC 
TCTCCAGTTA GCAAAGGAAT TCTTCAGTAT GATATGTGGA ATGTTACTCC TACAGACCTA 
TGGGACTGGA AGGTTCTCAA GGAGAAGATT GCAAAGTATG GTATAAGAAA CAGTTTACTT 
ATTGCCCCGA TGCCTACAGC TTCCACTGCT CAGATCCTGG GGAATAATGA GTCCATTGAA 
CCTTACACCA GCAACATCTA TACTCGCAGA GTCTTGTCAG GAGAATTTCA GATTGTAAAT 
CCTCACTTAT TGAAAGATCT TACCGAGCGG GGCCTATGGC ATGAAGAGAT GAAAAACCAG 
ATTATTGCAT GCAATGGCTC TATTCAGAGC ATACCAGAAA TTCCTGATGA CCTGAAGCAA 
CTTTATAAAA CTGTGTGGGA AATCTCTCAG AAAACTGTTC TCAAGATGGC AGCTGAGAGA 
GGTGCTTTCA TTGATCAAAG CCAATCTTTG AACATCCACA TTGCTGAGCC TAACTATGGC 
AAACTCACTA GTATGCACTT CTACGGCTGG AAGCAGGGTT TGAAGACTGG GATGTATTAT 
TTAAGGACAA GACCAGCGGC TAATCCAATC CAGTTCACTC TAAATAAGGA GAAGCTAAAA 
GATAAAGAAA AGGTATCAAA AGAGGAAGAA GAGAAGGAGA GGAACACAGC AGCCATGGTG 
TGCTCTTTGG AGAATAGAGA TGAATGTCTG ATGTGTGGAT CCTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

PubMed

Effect of ribonucleotide reductase M1 expression on overall survival in patients with pancreatic cancer receiving gemcitabine chemotherapy: A literature-based meta-analysis.
Journal of clinical pharmacy and therapeutics(2017 Dec)
Han QL,Zhou YH,Lyu Y,Yan H,Dai GH

Clinical pharmacology and clinical trials of ribonucleotide reductase inhibitors: is it a viable cancer therapy?
Journal of cancer research and clinical oncology143(8)1499-1529(2017 Aug)
Mannargudi MB,Deb S

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RRM1 cDNA ORF clone, Homo sapiens(human)

Gene

Clones

gRNAs

Related articles in PubMed

Target ORF information:

Target ORF information:

ORF Insert Sequence:

Target ORF information:

Target ORF information:

ORF Insert Sequence:

Target ORF information:

Target ORF information:

ORF Insert Sequence:

Target ORF information:

Target ORF information:

ORF Insert Sequence:

Target ORF information:

Target ORF information:

ORF Insert Sequence:

Target ORF information:

Target ORF information:

ORF Insert Sequence:

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