BDKRB1 cDNA ORF clone, Homo sapiens(human)

Gene
Clones
gRNAs

Summary

Gene Symbol	BDKRB1
Entrez Gene ID	623
Full Name	bradykinin receptor B1
Synonyms	B1BKR,B1R,BDKRB2,BKB1R,BKR1,BRADYB1
General protein information	Preferred Names bradykinin receptor B1 Names B1 bradykinin receptor BK-1 receptor bradykinin B1 receptor bradykinin receptor 1 bradykinin receptor B2
Gene Type	protein-coding
Organism	Homo sapiens(human)
Genome	Chromosome: 14 Map Location: 14q32.2
Summary	Bradykinin, a 9 aa peptide, is generated in pathophysiologic conditions such as inflammation, trauma, burns, shock, and allergy. Two types of G-protein coupled receptors have been found which bind bradykinin and mediate responses to these pathophysiologic conditions. The protein encoded by this gene is one of these receptors and is synthesized de novo following tissue injury. Receptor binding leads to an increase in the cytosolic calcium ion concentration, ultimately resulting in chronic and acute inflammatory responses. Several transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Sep 2011].
Disorder MIM:	600337

mRNA and Protein(s)

mRNA	Protein	Name
NM_000710.3	NP_000701.2	B1 bradykinin receptor
NM_000710.4	NP_000701.2	B1 bradykinin receptor

Pathways from BioSystems

Homologies

Bos taurus (cattle)	BDKRB1	NP_001103469.1
Canis lupus familiaris (dog)	BDKRB1	NP_001014306.1
Pan troglodytes (chimpanzee)	BDKRB1	XP_003314558.1
Mus musculus (house mouse)	Bdkrb1	NP_031565.1
Homo sapiens (human)	BDKRB1	NP_000701.2
Rattus norvegicus (Norway rat)	Bdkrb1	NP_110478.1
Gallus gallus (chicken)	BDKRB1	NP_001074189.1

Gene Ontology
Bibliography

Related articles in PubMed

Bradykinin receptors gene expression in white adipose tissue in nondiabetic patients with coronary artery disease.
Marketou ME, Kochiadakis G, Kontaraki J, Zacharis E, Kanoupakis E, Kallergis E, Mavrakis H, Tsiverdis P, Lempidakis D, Konstantinou J, Fragkiadakis K, Chlouverakis G, Vardas P, Parthenakis F
Coronary artery disease(2018 Jan)

Attenuation of pulmonary ACE2 activity impairs inactivation of des-Arg
Sodhi CP, Wohlford-Lenane C, Yamaguchi Y, Prindle T, Fulton WB, Wang S, McCray PB Jr., Chappell M, Hackam DJ, Jia H
American journal of physiology. Lung cellular and molecular physiology314(1)L17-L31(2018 Jan)

Kinin B1 receptor as a novel, prognostic progression biomarker for carotid atherosclerotic plaques.
Liu T, Liu H, Feng L, Xiao B
Molecular medicine reports16(6)8930-8936(2017 Dec)

Bradykinin system is involved in endometriosis-related pain through endothelin-1 production.
Yoshino O, Yamada-Nomoto K, Kobayashi M, Andoh T, Hongo M, Ono Y, Hasegawa-Idemitsu A, Sakai A, Osuga Y, Saito S
European journal of pain (London, England)(2017 Oct)

GeneRIFs: Gene References Into Functions What's a GeneRIF?

Data show that mRNA and protein of bradykinin type 2 receptors, but not bradykinin type 1 receptors, were abundant in cultured c-Kit+ progenitor cells.
Title: Bradykinin regulates cell growth and migration in cultured human cardiac c-Kit+ progenitor cells.

promotes adhesion of neutrophils to endothelial cells
Title: Kinin B1 receptor regulates interactions between neutrophils and endothelial cells by modulating the levels of Mac-1, LFA-1 and intercellular adhesion molecule-1.

kB1R heterodimerizes with kB2Rs in co-transfected HEK293 cells and natively expressing endothelial cells, resulting in significant internalization and desensitization of the kB1R response in cells pre-treated with kB2R agonist.
Title: Downregulation of kinin B1 receptor function by B2 receptor heterodimerization and signaling.

B1R agonist acts as a functional stimulus for the secretion of KLK1 and KLK6, an event relevant for kinin production and cell invasion, respectively
Title: Bioregulation of kallikrein-related peptidases 6, 10 and 11 by the kinin B? receptor in breast cancer cells.

APJ and B1R can form heterodimers in transfected HEK293 cells and activations of APJ and B1R could up-regulate eNOS phosphorylation
Title: Heterodimerization of human apelin and bradykinin 1 receptors: novel signal transduction characteristics.

The following BDKRB1 gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the BDKRB1 cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1⁺/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.

***CloneID	Accession No.	Definition	**Vector	*Turnaround time	Price (USD)
OHu10232	NM_000710.4 Latest version!	Homo sapiens bradykinin receptor B1 (BDKRB1), mRNA.	pcDNA3.1-C-(k)DYK or customized vector	in pcDNA3.1-C-(k)DYK	$189.50-$265.30 $379.00
View Old Accession Versions >>
OHu10232	NM_000710.3	Homo sapiens bradykinin receptor B1 (BDKRB1), mRNA.	pcDNA3.1-C-(k)DYK or customized vector	in pcDNA3.1-C-(k)DYK	$189.50-$265.30 $379.00
Hide Old Accession Versions >>

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** GenScript guarantees 100% sequence accuracy of all synthetic DNA constructs we deliver, but we do not guarantee protein expression in your experimental system. Protein expression is influenced by many factors that may vary between experiments or laboratories. In addition, please pay attention to the signal peptide, propeptide and transit peptide in target ORF, which may affect the choice of vector (N/C terminal tag vector).

***One clone ID might be correlated to multiple accession numbers, which share the same CDS sequence.

Reference Sequences (Refseq)

BDKRB1 ( NM_000710.3 ) cDNA ORF clone, Homo sapiens(human) -> NP_000701.2 Homo sapiens bradykinin receptor B1 (BDKRB1), mRNA.

Price & Availability↑

CloneID	OHu10232
Clone ID Related Accession (Same CDS sequence)	NM_000710.3 , NM_000710.4
Accession Version	NM_000710.3	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 1062bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2017-10-02
Organism	Homo sapiens(human)
Product	B1 bradykinin receptor
Comment	Comment: REVIEWED REFSEQ: This record has been curated by NCBI staff. The reference sequence was derived from CB130642.1, AL355102.5 and AJ238044.1. On Sep 17, 2011 this sequence version replaced NM_000710.2. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: AJ238044.1, AK291970.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA1966682, SAMEA1968189 [ECO:0000348] ##Evidence-Data-END## COMPLETENESS: full length.

ATGGCATCAT CCTGGCCCCC TCTAGAGCTC CAATCCTCCA ACCAGAGCCA GCTCTTCCCT 
CAAAATGCTA CGGCCTGTGA CAATGCTCCA GAAGCCTGGG ACCTGCTGCA CAGAGTGCTG 
CCAACATTTA TCATCTCCAT CTGTTTCTTC GGCCTCCTAG GGAACCTTTT TGTCCTGTTG 
GTCTTCCTCC TGCCCCGGCG GCAACTGAAC GTGGCAGAAA TCTACCTGGC CAACCTGGCA 
GCCTCTGATC TGGTGTTTGT CTTGGGCTTG CCCTTCTGGG CAGAGAATAT CTGGAACCAG 
TTTAACTGGC CTTTCGGAGC CCTCCTCTGC CGTGTCATCA ACGGGGTCAT CAAGGCCAAT 
TTGTTCATCA GCATCTTCCT GGTGGTGGCC ATCAGCCAGG ACCGCTACCG CGTGCTGGTG 
CACCCTATGG CCAGCCGGAG GCAGCAGCGG CGGAGGCAGG CCCGGGTCAC CTGCGTGCTC 
ATCTGGGTTG TGGGGGGCCT CTTGAGCATC CCCACATTCC TGCTGCGATC CATCCAAGCC 
GTCCCAGATC TGAACATCAC CGCCTGCATC CTGCTCCTCC CCCATGAGGC CTGGCACTTT 
GCAAGGATTG TGGAGTTAAA TATTCTGGGT TTCCTCCTAC CACTGGCTGC GATCGTCTTC 
TTCAACTACC ACATCCTGGC CTCCCTGCGA ACGCGGGAGG AGGTCAGCAG GACAAGGTGC 
GGGGGCCGCA AGGATAGCAA GACCACAGCG CTGATCCTCA CGCTCGTGGT TGCCTTCCTG 
GTCTGCTGGG CCCCTTACCA CTTCTTTGCC TTCCTGGAAT TCTTATTCCA GGTGCAAGCA 
GTCCGAGGCT GCTTTTGGGA GGACTTCATT GACCTGGGCC TGCAATTGGC CAACTTCTTT 
GCCTTCACTA ACAGCTCCCT GAATCCAGTA ATTTATGTCT TTGTGGGCCG GCTCTTCAGG 
ACCAAGGTCT GGGAACTTTA TAAACAATGC ACCCCTAAAA GTCTTGCTCC AATATCTTCA 
TCCCATAGGA AAGAAATCTT CCAACTTTTC TGGCGGAATT AA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_000701.2
CDS	221..1282
Translation	MASSWPPLELQSSNQSQLFPQNATACDNAPEAWDLLHRVLPTFIISICFFGLLGNLFVLLVFLLPRRQLNVAEIYLANLAASDLVFVLGLPFWAENIWNQFNWPFGALLCRVINGVIKANLFISIFLVVAISQDRYRVLVHPMASRRQQRRRQARVTCVLIWVVGGLLSIPTFLLRSIQAVPDLNITACILLLPHEAWHFARIVELNILGFLLPLAAIVFFNYHILASLRTREEVSRTRCGGRKDSKTTALILTLVVAFLVCWAPYHFFAFLEFLFQVQAVRGCFWEDFIDLGLQLANFFAFTNSSLNPVIYVFVGRLFRTKVWELYKQCTPKSLAPISSSHRKEIFQLFWRN

Target ORF information:

RefSeq Version	NM_000710.3
Organism	Homo sapiens(human)
Definition	Homo sapiens bradykinin receptor B1 (BDKRB1), mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_000710.3

ORF Insert Sequence:

ATGGCATCAT CCTGGCCCCC TCTAGAGCTC CAATCCTCCA ACCAGAGCCA GCTCTTCCCT 
CAAAATGCTA CGGCCTGTGA CAATGCTCCA GAAGCCTGGG ACCTGCTGCA CAGAGTGCTG 
CCAACATTTA TCATCTCCAT CTGTTTCTTC GGCCTCCTAG GGAACCTTTT TGTCCTGTTG 
GTCTTCCTCC TGCCCCGGCG GCAACTGAAC GTGGCAGAAA TCTACCTGGC CAACCTGGCA 
GCCTCTGATC TGGTGTTTGT CTTGGGCTTG CCCTTCTGGG CAGAGAATAT CTGGAACCAG 
TTTAACTGGC CTTTCGGAGC CCTCCTCTGC CGTGTCATCA ACGGGGTCAT CAAGGCCAAT 
TTGTTCATCA GCATCTTCCT GGTGGTGGCC ATCAGCCAGG ACCGCTACCG CGTGCTGGTG 
CACCCTATGG CCAGCCGGAG GCAGCAGCGG CGGAGGCAGG CCCGGGTCAC CTGCGTGCTC 
ATCTGGGTTG TGGGGGGCCT CTTGAGCATC CCCACATTCC TGCTGCGATC CATCCAAGCC 
GTCCCAGATC TGAACATCAC CGCCTGCATC CTGCTCCTCC CCCATGAGGC CTGGCACTTT 
GCAAGGATTG TGGAGTTAAA TATTCTGGGT TTCCTCCTAC CACTGGCTGC GATCGTCTTC 
TTCAACTACC ACATCCTGGC CTCCCTGCGA ACGCGGGAGG AGGTCAGCAG GACAAGGTGC 
GGGGGCCGCA AGGATAGCAA GACCACAGCG CTGATCCTCA CGCTCGTGGT TGCCTTCCTG 
GTCTGCTGGG CCCCTTACCA CTTCTTTGCC TTCCTGGAAT TCTTATTCCA GGTGCAAGCA 
GTCCGAGGCT GCTTTTGGGA GGACTTCATT GACCTGGGCC TGCAATTGGC CAACTTCTTT 
GCCTTCACTA ACAGCTCCCT GAATCCAGTA ATTTATGTCT TTGTGGGCCG GCTCTTCAGG 
ACCAAGGTCT GGGAACTTTA TAAACAATGC ACCCCTAAAA GTCTTGCTCC AATATCTTCA 
TCCCATAGGA AAGAAATCTT CCAACTTTTC TGGCGGAATT AA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

BDKRB1 ( NM_000710.4 ) cDNA ORF clone, Homo sapiens(human) -> NP_000701.2 Homo sapiens bradykinin receptor B1 (BDKRB1), mRNA.

Price & Availability↑

CloneID	OHu10232
Clone ID Related Accession (Same CDS sequence)	NM_000710.3 , NM_000710.4
Accession Version	NM_000710.4 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 1062bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-12-29
Organism	Homo sapiens(human)
Product	B1 bradykinin receptor
Comment	Comment: REVIEWED REFSEQ: This record has been curated by NCBI staff. The reference sequence was derived from CB130642.1, AL355102.5 and AJ238044.1. On Nov 22, 2018 this sequence version replaced NM_000710.3. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: AJ238044.1, SRR5189658.207297.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA1966682, SAMEA1968189 [ECO:0000348] ##Evidence-Data-END## ##RefSeq-Attributes-START## MANE Ensembl match :: ENST00000216629.11/ ENSP00000216629.6 RefSeq Select criteria :: based on single protein-coding transcript ##RefSeq-Attributes-END## COMPLETENESS: full length.

ATGGCATCAT CCTGGCCCCC TCTAGAGCTC CAATCCTCCA ACCAGAGCCA GCTCTTCCCT 
CAAAATGCTA CGGCCTGTGA CAATGCTCCA GAAGCCTGGG ACCTGCTGCA CAGAGTGCTG 
CCAACATTTA TCATCTCCAT CTGTTTCTTC GGCCTCCTAG GGAACCTTTT TGTCCTGTTG 
GTCTTCCTCC TGCCCCGGCG GCAACTGAAC GTGGCAGAAA TCTACCTGGC CAACCTGGCA 
GCCTCTGATC TGGTGTTTGT CTTGGGCTTG CCCTTCTGGG CAGAGAATAT CTGGAACCAG 
TTTAACTGGC CTTTCGGAGC CCTCCTCTGC CGTGTCATCA ACGGGGTCAT CAAGGCCAAT 
TTGTTCATCA GCATCTTCCT GGTGGTGGCC ATCAGCCAGG ACCGCTACCG CGTGCTGGTG 
CACCCTATGG CCAGCCGGAG GCAGCAGCGG CGGAGGCAGG CCCGGGTCAC CTGCGTGCTC 
ATCTGGGTTG TGGGGGGCCT CTTGAGCATC CCCACATTCC TGCTGCGATC CATCCAAGCC 
GTCCCAGATC TGAACATCAC CGCCTGCATC CTGCTCCTCC CCCATGAGGC CTGGCACTTT 
GCAAGGATTG TGGAGTTAAA TATTCTGGGT TTCCTCCTAC CACTGGCTGC GATCGTCTTC 
TTCAACTACC ACATCCTGGC CTCCCTGCGA ACGCGGGAGG AGGTCAGCAG GACAAGGTGC 
GGGGGCCGCA AGGATAGCAA GACCACAGCG CTGATCCTCA CGCTCGTGGT TGCCTTCCTG 
GTCTGCTGGG CCCCTTACCA CTTCTTTGCC TTCCTGGAAT TCTTATTCCA GGTGCAAGCA 
GTCCGAGGCT GCTTTTGGGA GGACTTCATT GACCTGGGCC TGCAATTGGC CAACTTCTTT 
GCCTTCACTA ACAGCTCCCT GAATCCAGTA ATTTATGTCT TTGTGGGCCG GCTCTTCAGG 
ACCAAGGTCT GGGAACTTTA TAAACAATGC ACCCCTAAAA GTCTTGCTCC AATATCTTCA 
TCCCATAGGA AAGAAATCTT CCAACTTTTC TGGCGGAATT AA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_000701.2
CDS	221..1282
Translation	MASSWPPLELQSSNQSQLFPQNATACDNAPEAWDLLHRVLPTFIISICFFGLLGNLFVLLVFLLPRRQLNVAEIYLANLAASDLVFVLGLPFWAENIWNQFNWPFGALLCRVINGVIKANLFISIFLVVAISQDRYRVLVHPMASRRQQRRRQARVTCVLIWVVGGLLSIPTFLLRSIQAVPDLNITACILLLPHEAWHFARIVELNILGFLLPLAAIVFFNYHILASLRTREEVSRTRCGGRKDSKTTALILTLVVAFLVCWAPYHFFAFLEFLFQVQAVRGCFWEDFIDLGLQLANFFAFTNSSLNPVIYVFVGRLFRTKVWELYKQCTPKSLAPISSSHRKEIFQLFWRN

Target ORF information:

RefSeq Version	NM_000710.4
Organism	Homo sapiens(human)
Definition	Homo sapiens bradykinin receptor B1 (BDKRB1), mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_000710.4

ORF Insert Sequence:

ATGGCATCAT CCTGGCCCCC TCTAGAGCTC CAATCCTCCA ACCAGAGCCA GCTCTTCCCT 
CAAAATGCTA CGGCCTGTGA CAATGCTCCA GAAGCCTGGG ACCTGCTGCA CAGAGTGCTG 
CCAACATTTA TCATCTCCAT CTGTTTCTTC GGCCTCCTAG GGAACCTTTT TGTCCTGTTG 
GTCTTCCTCC TGCCCCGGCG GCAACTGAAC GTGGCAGAAA TCTACCTGGC CAACCTGGCA 
GCCTCTGATC TGGTGTTTGT CTTGGGCTTG CCCTTCTGGG CAGAGAATAT CTGGAACCAG 
TTTAACTGGC CTTTCGGAGC CCTCCTCTGC CGTGTCATCA ACGGGGTCAT CAAGGCCAAT 
TTGTTCATCA GCATCTTCCT GGTGGTGGCC ATCAGCCAGG ACCGCTACCG CGTGCTGGTG 
CACCCTATGG CCAGCCGGAG GCAGCAGCGG CGGAGGCAGG CCCGGGTCAC CTGCGTGCTC 
ATCTGGGTTG TGGGGGGCCT CTTGAGCATC CCCACATTCC TGCTGCGATC CATCCAAGCC 
GTCCCAGATC TGAACATCAC CGCCTGCATC CTGCTCCTCC CCCATGAGGC CTGGCACTTT 
GCAAGGATTG TGGAGTTAAA TATTCTGGGT TTCCTCCTAC CACTGGCTGC GATCGTCTTC 
TTCAACTACC ACATCCTGGC CTCCCTGCGA ACGCGGGAGG AGGTCAGCAG GACAAGGTGC 
GGGGGCCGCA AGGATAGCAA GACCACAGCG CTGATCCTCA CGCTCGTGGT TGCCTTCCTG 
GTCTGCTGGG CCCCTTACCA CTTCTTTGCC TTCCTGGAAT TCTTATTCCA GGTGCAAGCA 
GTCCGAGGCT GCTTTTGGGA GGACTTCATT GACCTGGGCC TGCAATTGGC CAACTTCTTT 
GCCTTCACTA ACAGCTCCCT GAATCCAGTA ATTTATGTCT TTGTGGGCCG GCTCTTCAGG 
ACCAAGGTCT GGGAACTTTA TAAACAATGC ACCCCTAAAA GTCTTGCTCC AATATCTTCA 
TCCCATAGGA AAGAAATCTT CCAACTTTTC TGGCGGAATT AA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

PubMed

Bradykinin receptors gene expression in white adipose tissue in nondiabetic patients with coronary artery disease.
Coronary artery disease(2018 Jan)
Marketou ME,Kochiadakis G,Kontaraki J,Zacharis E,Kanoupakis E,Kallergis E,Mavrakis H,Tsiverdis P,Lempidakis D,Konstantinou J,Fragkiadakis K,Chlouverakis G,Vardas P,Parthenakis F

Attenuation of pulmonary ACE2 activity impairs inactivation of des-Arg
American journal of physiology. Lung cellular and molecular physiology314(1)L17-L31(2018 Jan)
Sodhi CP,Wohlford-Lenane C,Yamaguchi Y,Prindle T,Fulton WB,Wang S,McCray PB Jr.,Chappell M,Hackam DJ,Jia H

Kinin B1 receptor as a novel, prognostic progression biomarker for carotid atherosclerotic plaques.
Molecular medicine reports16(6)8930-8936(2017 Dec)
Liu T,Liu H,Feng L,Xiao B

Bradykinin system is involved in endometriosis-related pain through endothelin-1 production.
European journal of pain (London, England)(2017 Oct)
Yoshino O,Yamada-Nomoto K,Kobayashi M,Andoh T,Hongo M,Ono Y,Hasegawa-Idemitsu A,Sakai A,Osuga Y,Saito S

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BDKRB1 cDNA ORF clone, Homo sapiens(human)

Gene

Clones

gRNAs

Related articles in PubMed

Target ORF information:

Target ORF information:

ORF Insert Sequence:

Target ORF information:

Target ORF information:

ORF Insert Sequence:

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