RPS17 cDNA ORF clone, Homo sapiens(Human)

Gene
Clones
gRNAs

Summary

Gene Symbol	RPS17
Entrez Gene ID	6218
Full Name	ribosomal protein S17
Synonyms	DBA4,RPS17L,RPS17L1,RPS17L2,S17
General protein information	Preferred Names ribosomal protein S17 Names 40S ribosomal protein S17 small ribosomal subunit protein eS17
Gene Type	protein-coding
Organism	Homo sapiens(Human)
Genome	Chromosome: 15 Map Location: 15q25.2
Summary	Ribosomes, the organelles that catalyze protein synthesis, consist of a small 40S subunit and a large 60S subunit. Together these subunits are composed of four RNA species and approximately 80 structurally distinct proteins. This gene encodes a ribosomal protein that is a component of the 40S subunit. The protein belongs to the S17E family of ribosomal proteins and is located in the cytoplasm. Mutations in this gene cause Diamond-Blackfan anemia 4. Alternative splicing of this gene results in multiple transcript variants. As is typical for genes encoding ribosomal proteins, there are multiple processed pseudogenes of this gene dispersed through the genome. [provided by RefSeq, Apr 2014].
Disorder MIM:	180472
Disorder Html:	Diamond-Blackfan anemia 4, 612527 (3)

mRNA and Protein(s)

mRNA	Protein	Name
NM_001021.5	NP_001012.1	40S ribosomal protein S17
NM_001021.6	NP_001012.1	40S ribosomal protein S17
NM_001021.4	NP_001012.1	40S ribosomal protein S17

Pathways from BioSystems

Homologies

Pan troglodytes (chimpanzee)	RPS17	XP_525570.2
	RPS17L	XP_002804971.1
Kluyveromyces lactis	KLLA0B01474g	XP_451596.2
Oryza sativa (rice)	Os10g0411800	NP_001064585.1
Homo sapiens (human)	RPS17	NP_001012.1
Mus musculus (house mouse)	Rps17	NP_033118.1
Saccharomyces cerevisiae (baker's yeast)	RPS17A	NP_013688.1
Schizosaccharomyces pombe (fission yeast)	rps1701	NP_595245.1
Gallus gallus (chicken)	RPS17L	NP_989548.1
Saccharomyces cerevisiae (baker's yeast)	RPS17B	NP_010735.3
Arabidopsis thaliana (thale cress)	AT3G10610	NP_187672.1
Canis lupus familiaris (dog)	RPS17	NP_001003099.1
Eremothecium gossypii	AGOS_AER319W	NP_985175.1
Arabidopsis thaliana (thale cress)	AT5G04800	NP_001031834.1
Oryza sativa (rice)	Os03g0109500	NP_001048708.1
Xenopus tropicalis (tropical clawed frog)	rps17	XP_002938919.1
Bos taurus (cattle)	RPS17	NP_001092680.1
Danio rerio (zebrafish)	zgc:114188	NP_001013473.1
Caenorhabditis elegans (roundworm)	rps-17	NP_491795.1
Schizosaccharomyces pombe (fission yeast)	rps1702	NP_588012.1
Magnaporthe oryzae (rice blast fungus)	MGG_04114	XP_003719717.1
Neurospora crassa	NCU07014	XP_961835.1
Arabidopsis thaliana (thale cress)	AT2G04390	NP_178520.1
Arabidopsis thaliana (thale cress)	AT2G05220	NP_565320.1

Gene Ontology
Bibliography

Related articles in PubMed

Identification and fine mapping of nuclear and nucleolar localization signals within the human ribosomal protein S17.
Kenney SP, Meng XJ
PloS one10(4)e0124396(2015)

Ribosomal protein mutations in Korean patients with Diamond-Blackfan anemia.
Chae H, Park J, Lee S, Kim M, Kim Y, Lee JW, Chung NG, Cho B, Jeong DC, Kim J, Kim JR, Park G
Experimental & molecular medicine46e88(2014 Mar)

SILAC-based proteomics of human primary endothelial cell morphogenesis unveils tumor angiogenic markers.
Zanivan S, Maione F, Hein MY, Hern?ndez-Fernaud JR, Ostasiewicz P, Giraudo E, Mann M
Molecular & cellular proteomics : MCP12(12)3599-611(2013 Dec)

The mRNA-bound proteome and its global occupancy profile on protein-coding transcripts.
Baltz AG, Munschauer M, Schwanh?usser B, Vasile A, Murakawa Y, Schueler M, Youngs N, Penfold-Brown D, Drew K, Milek M, Wyler E, Bonneau R, Selbach M, Dieterich C, Landthaler M
Molecular cell46(5)674-90(2012 Jun)

GeneRIFs: Gene References Into Functions What's a GeneRIF?

Nuclear and nucleolar localization signals within the human ribosomal protein S17 have been mapped.
Title: Identification and fine mapping of nuclear and nucleolar localization signals within the human ribosomal protein S17.

Human S17 insertion was a major factor for hepatitis E virus in cell culture adaptation.
Title: Adaptation of a genotype 3 hepatitis E virus to efficient growth in cell culture depends on an inserted human gene segment acquired by recombination.

Data show 1 proband with an RPL5 deletion, 1 patient with an RPL35A deletion, 3 with RPS17 deletions, and 1 with an RPS19 deletion.
Title: Extensive gene deletions in Japanese patients with Diamond-Blackfan anemia.

Studies identified deletions at known Diamond-Blackfan anemia (DBA)-related ribosomal protein gene loci in 17% (9 of 51) of patients without an identifiable mutation, including RPS19, RPS17, RPS26, and RPL35A.
Title: Ribosomal protein gene deletions in Diamond-Blackfan anemia.

Observational study of gene-disease association. (HuGE Navigator)
Title: Mutations in the ribosomal protein genes in Japanese patients with Diamond-Blackfan anemia.

The following RPS17 gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the RPS17 cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1⁺/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.

***CloneID	Accession No.	Definition	**Vector	*Turnaround time	Price (USD)
OHu23517	NM_001021.6 Latest version!	Homo sapiens ribosomal protein S17 (RPS17), transcript variant 1, mRNA.	pcDNA3.1-C-(k)DYK or customized vector	in pcDNA3.1-C-(k)DYK	$49.50-$69.30 $99.00
View Old Accession Versions >>
OHu23517	NM_001021.5	Homo sapiens ribosomal protein S17 (RPS17), transcript variant 1, mRNA.	pcDNA3.1-C-(k)DYK or customized vector	in pcDNA3.1-C-(k)DYK	$49.50-$69.30 $99.00
OHu23517	NM_001021.4	Homo sapiens ribosomal protein S17 (RPS17), transcript variant 1, mRNA.	pcDNA3.1-C-(k)DYK or customized vector	in pcDNA3.1-C-(k)DYK	$49.50-$69.30 $99.00
Hide Old Accession Versions >>

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** GenScript guarantees 100% sequence accuracy of all synthetic DNA constructs we deliver, but we do not guarantee protein expression in your experimental system. Protein expression is influenced by many factors that may vary between experiments or laboratories. In addition, please pay attention to the signal peptide, propeptide and transit peptide in target ORF, which may affect the choice of vector (N/C terminal tag vector).

***One clone ID might be correlated to multiple accession numbers, which share the same CDS sequence.

Reference Sequences (Refseq)

RPS17 ( NM_001021.5 ) cDNA ORF clone, Homo sapiens(Human) -> NP_001012.1 Homo sapiens ribosomal protein S17 (RPS17), transcript variant 1, mRNA.

Price & Availability↑

CloneID	OHu23517
Clone ID Related Accession (Same CDS sequence)	NM_001021.5 , NM_001021.6 , NM_001021.4
Accession Version	NM_001021.5	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 408bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2017-12-27
Organism	Homo sapiens(human)
Product	40S ribosomal protein S17
Comment	Comment: REVIEWED REFSEQ: This record has been curated by NCBI staff in collaboration with Francesco Amaldi. The reference sequence was derived from AC245033.2, BC062715.1 and BE905890.1. This sequence is a reference standard in the RefSeqGene project. On Aug 31, 2017 this sequence version replaced NM_001021.4. Transcript Variant: This variant (1) encodes the supported protein. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: CD246863.1, BC062715.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA1966682, SAMEA1968189 [ECO:0000348] ##Evidence-Data-END## COMPLETENESS: complete on the 3' end.

ATGGGCCGCG TTCGCACCAA AACCGTGAAG AAGGCGGCCC GGGTCATCAT AGAAAAGTAC 
TACACGCGCC TGGGCAACGA CTTCCACACG AACAAGCGCG TGTGCGAGGA GATCGCCATT 
ATCCCCAGCA AAAAGCTCCG CAACAAGATA GCAGGTTATG TCACGCATCT GATGAAGCGA 
ATTCAGAGAG GCCCAGTAAG AGGTATCTCC ATCAAGCTGC AGGAGGAGGA GAGAGAAAGG 
AGAGACAATT ATGTTCCTGA GGTCTCAGCC TTGGATCAGG AGATTATTGA AGTAGATCCT 
GACACTAAGG AAATGCTGAA GCTTTTGGAC TTCGGCAGTC TGTCCAACCT TCAGGTCACT 
CAGCCTACAG TTGGGATGAA TTTCAAAACG CCTCGGGGAC CTGTTTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_001012.1
CDS	137..544
Translation	MGRVRTKTVKKAARVIIEKYYTRLGNDFHTNKRVCEEIAIIPSKKLRNKIAGYVTHLMKRIQRGPVRGISIKLQEEERERRDNYVPEVSALDQEIIEVDPDTKEMLKLLDFGSLSNLQVTQPTVGMNFKTPRGPV

Target ORF information:

RefSeq Version	NM_001021.5
Organism	Homo sapiens(human)
Definition	Homo sapiens ribosomal protein S17 (RPS17), transcript variant 1, mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_001021.5

ORF Insert Sequence:

ATGGGCCGCG TTCGCACCAA AACCGTGAAG AAGGCGGCCC GGGTCATCAT AGAAAAGTAC 
TACACGCGCC TGGGCAACGA CTTCCACACG AACAAGCGCG TGTGCGAGGA GATCGCCATT 
ATCCCCAGCA AAAAGCTCCG CAACAAGATA GCAGGTTATG TCACGCATCT GATGAAGCGA 
ATTCAGAGAG GCCCAGTAAG AGGTATCTCC ATCAAGCTGC AGGAGGAGGA GAGAGAAAGG 
AGAGACAATT ATGTTCCTGA GGTCTCAGCC TTGGATCAGG AGATTATTGA AGTAGATCCT 
GACACTAAGG AAATGCTGAA GCTTTTGGAC TTCGGCAGTC TGTCCAACCT TCAGGTCACT 
CAGCCTACAG TTGGGATGAA TTTCAAAACG CCTCGGGGAC CTGTTTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RPS17 ( NM_001021.6 ) cDNA ORF clone, Homo sapiens(Human) -> NP_001012.1 Homo sapiens ribosomal protein S17 (RPS17), transcript variant 1, mRNA.

Price & Availability↑

CloneID	OHu23517
Clone ID Related Accession (Same CDS sequence)	NM_001021.5 , NM_001021.6 , NM_001021.4
Accession Version	NM_001021.6 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 408bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-09-14
Organism	Homo sapiens(human)
Product	40S ribosomal protein S17
Comment	Comment: REVIEWED REFSEQ: This record has been curated by NCBI staff in collaboration with Francesco Amaldi. The reference sequence was derived from BC062715.1 and BE905890.1. This sequence is a reference standard in the RefSeqGene project. On May 8, 2018 this sequence version replaced NM_001021.5. Transcript Variant: This variant (1) encodes the supported protein. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: CD246863.1, BE902183.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA1966682, SAMEA1968189 [ECO:0000348] ##Evidence-Data-END## ##RefSeq-Attributes-START## MANE Ensembl match :: ENST00000647841.1/ ENSP00000498019.1 RefSeq Select criteria :: based on single protein-coding transcript ##RefSeq-Attributes-END## COMPLETENESS: complete on the 3' end.

ATGGGCCGCG TTCGCACCAA AACCGTGAAG AAGGCGGCCC GGGTCATCAT AGAAAAGTAC 
TACACGCGCC TGGGCAACGA CTTCCACACG AACAAGCGCG TGTGCGAGGA GATCGCCATT 
ATCCCCAGCA AAAAGCTCCG CAACAAGATA GCAGGTTATG TCACGCATCT GATGAAGCGA 
ATTCAGAGAG GCCCAGTAAG AGGTATCTCC ATCAAGCTGC AGGAGGAGGA GAGAGAAAGG 
AGAGACAATT ATGTTCCTGA GGTCTCAGCC TTGGATCAGG AGATTATTGA AGTAGATCCT 
GACACTAAGG AAATGCTGAA GCTTTTGGAC TTCGGCAGTC TGTCCAACCT TCAGGTCACT 
CAGCCTACAG TTGGGATGAA TTTCAAAACG CCTCGGGGAC CTGTTTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_001012.1
CDS	30..437
Translation	MGRVRTKTVKKAARVIIEKYYTRLGNDFHTNKRVCEEIAIIPSKKLRNKIAGYVTHLMKRIQRGPVRGISIKLQEEERERRDNYVPEVSALDQEIIEVDPDTKEMLKLLDFGSLSNLQVTQPTVGMNFKTPRGPV

Target ORF information:

RefSeq Version	NM_001021.6
Organism	Homo sapiens(human)
Definition	Homo sapiens ribosomal protein S17 (RPS17), transcript variant 1, mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_001021.6

ORF Insert Sequence:

ATGGGCCGCG TTCGCACCAA AACCGTGAAG AAGGCGGCCC GGGTCATCAT AGAAAAGTAC 
TACACGCGCC TGGGCAACGA CTTCCACACG AACAAGCGCG TGTGCGAGGA GATCGCCATT 
ATCCCCAGCA AAAAGCTCCG CAACAAGATA GCAGGTTATG TCACGCATCT GATGAAGCGA 
ATTCAGAGAG GCCCAGTAAG AGGTATCTCC ATCAAGCTGC AGGAGGAGGA GAGAGAAAGG 
AGAGACAATT ATGTTCCTGA GGTCTCAGCC TTGGATCAGG AGATTATTGA AGTAGATCCT 
GACACTAAGG AAATGCTGAA GCTTTTGGAC TTCGGCAGTC TGTCCAACCT TCAGGTCACT 
CAGCCTACAG TTGGGATGAA TTTCAAAACG CCTCGGGGAC CTGTTTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RPS17 ( NM_001021.4 ) cDNA ORF clone, Homo sapiens(Human) -> NP_001012.1 Homo sapiens ribosomal protein S17 (RPS17), transcript variant 1, mRNA.

Price & Availability↑

CloneID	OHu23517
Clone ID Related Accession (Same CDS sequence)	NM_001021.5 , NM_001021.6 , NM_001021.4
Accession Version	NM_001021.4	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 408bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2017-03-26
Organism	Homo sapiens(Human)
Product	40S ribosomal protein S17
Comment	REVIEWED REFSEQ: This record has been curated by NCBI staff in collaboration with Francesco Amaldi. The reference sequence was derived from BM017772.1, BC062715.1 and BE905890.1. This sequence is a reference standard in the RefSeqGene project. On Apr 8, 2014 this sequence version replaced NM_001021.3. Transcript Variant: This variant (1) encodes the supported protein. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: BI085304.1, BC062715.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA1966682, SAMEA1968189 [ECO:0000348] ##Evidence-Data-END## COMPLETENESS: complete on the 3' end.

ATGGGCCGCG TTCGCACCAA AACCGTGAAG AAGGCGGCCC GGGTCATCAT AGAAAAGTAC 
TACACGCGCC TGGGCAACGA CTTCCACACG AACAAGCGCG TGTGCGAGGA GATCGCCATT 
ATCCCCAGCA AAAAGCTCCG CAACAAGATA GCAGGTTATG TCACGCATCT GATGAAGCGA 
ATTCAGAGAG GCCCAGTAAG AGGTATCTCC ATCAAGCTGC AGGAGGAGGA GAGAGAAAGG 
AGAGACAATT ATGTTCCTGA GGTCTCAGCC TTGGATCAGG AGATTATTGA AGTAGATCCT 
GACACTAAGG AAATGCTGAA GCTTTTGGAC TTCGGCAGTC TGTCCAACCT TCAGGTCACT 
CAGCCTACAG TTGGGATGAA TTTCAAAACG CCTCGGGGAC CTGTTTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_001012.1
CDS	117..524
Translation	MGRVRTKTVKKAARVIIEKYYTRLGNDFHTNKRVCEEIAIIPSKKLRNKIAGYVTHLMKRIQRGPVRGISIKLQEEERERRDNYVPEVSALDQEIIEVDPDTKEMLKLLDFGSLSNLQVTQPTVGMNFKTPRGPV

Target ORF information:

RefSeq Version	NM_001021.4
Organism	Homo sapiens(Human)
Definition	Homo sapiens ribosomal protein S17 (RPS17), transcript variant 1, mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_001021.4

ORF Insert Sequence:

ATGGGCCGCG TTCGCACCAA AACCGTGAAG AAGGCGGCCC GGGTCATCAT AGAAAAGTAC 
TACACGCGCC TGGGCAACGA CTTCCACACG AACAAGCGCG TGTGCGAGGA GATCGCCATT 
ATCCCCAGCA AAAAGCTCCG CAACAAGATA GCAGGTTATG TCACGCATCT GATGAAGCGA 
ATTCAGAGAG GCCCAGTAAG AGGTATCTCC ATCAAGCTGC AGGAGGAGGA GAGAGAAAGG 
AGAGACAATT ATGTTCCTGA GGTCTCAGCC TTGGATCAGG AGATTATTGA AGTAGATCCT 
GACACTAAGG AAATGCTGAA GCTTTTGGAC TTCGGCAGTC TGTCCAACCT TCAGGTCACT 
CAGCCTACAG TTGGGATGAA TTTCAAAACG CCTCGGGGAC CTGTTTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

PubMed

Identification and fine mapping of nuclear and nucleolar localization signals within the human ribosomal protein S17.
PloS one10(4)e0124396(2015)
Kenney SP,Meng XJ

Ribosomal protein mutations in Korean patients with Diamond-Blackfan anemia.
Experimental & molecular medicine46e88(2014 Mar)
Chae H,Park J,Lee S,Kim M,Kim Y,Lee JW,Chung NG,Cho B,Jeong DC,Kim J,Kim JR,Park G

SILAC-based proteomics of human primary endothelial cell morphogenesis unveils tumor angiogenic markers.
Molecular & cellular proteomics : MCP12(12)3599-611(2013 Dec)
Zanivan S,Maione F,Hein MY,Hern?ndez-Fernaud JR,Ostasiewicz P,Giraudo E,Mann M

The mRNA-bound proteome and its global occupancy profile on protein-coding transcripts.
Molecular cell46(5)674-90(2012 Jun)
Baltz AG,Munschauer M,Schwanh?usser B,Vasile A,Murakawa Y,Schueler M,Youngs N,Penfold-Brown D,Drew K,Milek M,Wyler E,Bonneau R,Selbach M,Dieterich C,Landthaler M

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RPS17 cDNA ORF clone, Homo sapiens(Human)

Gene

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gRNAs

Related articles in PubMed

Target ORF information:

Target ORF information:

ORF Insert Sequence:

Target ORF information:

Target ORF information:

ORF Insert Sequence:

Target ORF information:

Target ORF information:

ORF Insert Sequence:

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