RPS12 cDNA ORF clone, Homo sapiens(human)

Gene
Clones
gRNAs

Summary

Gene Symbol	RPS12
Entrez Gene ID	6206
Full Name	ribosomal protein S12
Synonyms	S12
General protein information	Preferred Names ribosomal protein S12 Names 40S ribosomal protein S12 small ribosomal subunit protein eS12
Gene Type	protein-coding
Organism	Homo sapiens(human)
Genome	Chromosome: 6 Map Location: 6q23.2
Summary	Ribosomes, the organelles that catalyze protein synthesis, consist of a small 40S subunit and a large 60S subunit. Together these subunits are composed of 4 RNA species and approximately 80 structurally distinct proteins. This gene encodes a ribosomal protein that is a component of the 40S subunit. The protein belongs to the S12E family of ribosomal proteins. It is located in the cytoplasm. Increased expression of this gene in colorectal cancers compared to matched normal colonic mucosa has been observed. As is typical for genes encoding ribosomal proteins, there are multiple processed pseudogenes of this gene dispersed through the genome. [provided by RefSeq, Jul 2008].
Disorder MIM:	603660

mRNA and Protein(s)

mRNA	Protein	Name
NM_001016.3	NP_001007.2	40S ribosomal protein S12
NM_001016.4	NP_001007.2	40S ribosomal protein S12

Pathways from BioSystems

Homologies

Danio rerio (zebrafish)	rps12	NP_956340.1
Saccharomyces cerevisiae (baker's yeast)	RPS12	NP_015014.3
Arabidopsis thaliana (thale cress)	AT2G32060	NP_180766.1
Xenopus tropicalis (tropical clawed frog)	rps12	NP_001008435.1
	LOC706087	XP_001094299.1
	RPS12	XP_002803937.1
Mus musculus (house mouse)	Rps12	NP_035425.2
Rattus norvegicus (Norway rat)	Rps12	NP_113897.2
Eremothecium gossypii	AGOS_ADR412C	NP_984507.1
Neurospora crassa	NCU06432	XP_957323.2
Homo sapiens (human)	RPS12	NP_001007.2
Canis lupus familiaris (dog)	RPS12	XP_849673.1
Schizosaccharomyces pombe (fission yeast)	rps1201	NP_587869.1
Arabidopsis thaliana (thale cress)	AT1G15930	NP_173045.1
Pan troglodytes (chimpanzee)	RPS12	NP_001239438.1
Bos taurus (cattle)	RPS12	NP_001014409.1
Gallus gallus (chicken)	RPS12	NP_001264840.1
Schizosaccharomyces pombe (fission yeast)	rps1202	NP_595206.1
Oryza sativa (rice)	Os07g0229900	NP_001059229.1
Caenorhabditis elegans (roundworm)	rps-12	NP_498221.1
Kluyveromyces lactis	KLLA0F00352g	XP_455095.1
Magnaporthe oryzae (rice blast fungus)	MGG_06480	XP_003717083.1
Oryza sativa (rice)	Os07g0150200	NP_001058899.2

Gene Ontology
Bibliography

Related articles in PubMed

Analysis of rpsL and rrs genes mutations related to streptomycin resistance in Mdr and Xdr clinical isolates of Mycobacterium tuberculosis.
Arjomandzadegan M, Gravand S
Tuberkuloz ve toraks63(4)235-42(2015)

RPS12-specific shRNA inhibits the proliferation, migration of BGC823 gastric cancer cells with S100A4 as a downstream effector.
Chen D, Zhang R, Shen W, Fu H, Liu S, Sun K, Sun X
International journal of oncology42(5)1763-9(2013 May)

Insights into RNA biology from an atlas of mammalian mRNA-binding proteins.
Castello A, Fischer B, Eichelbaum K, Horos R, Beckmann BM, Strein C, Davey NE, Humphreys DT, Preiss T, Steinmetz LM, Krijgsveld J, Hentze MW
Cell149(6)1393-406(2012 Jun)

The mRNA-bound proteome and its global occupancy profile on protein-coding transcripts.
Baltz AG, Munschauer M, Schwanh?usser B, Vasile A, Murakawa Y, Schueler M, Youngs N, Penfold-Brown D, Drew K, Milek M, Wyler E, Bonneau R, Selbach M, Dieterich C, Landthaler M
Molecular cell46(5)674-90(2012 Jun)

A genome-wide association study for diabetic nephropathy genes in African Americans.
McDonough CW, Palmer ND, Hicks PJ, Roh BH, An SS, Cooke JN, Hester JM, Wing MR, Bostrom MA, Rudock ME, Lewis JP, Talbert ME, Blevins RA, Lu L, Ng MC, Sale MM, Divers J, Langefeld CD, Freedman BI, Bowden DW
Kidney international79(5)563-72(2011 Mar)

GeneRIFs: Gene References Into Functions What's a GeneRIF?

Streptomycin resistance is mainly related to mutation at codons 43 and 88 "rpsL" gene and to a lesser extent "rrs" that are the greatest cause of drug resistance to streptomycin.
Title: Analysis of rpsL and rrs genes mutations related to streptomycin resistance in Mdr and Xdr clinical isolates of Mycobacterium tuberculosis.

Our findings provide the first demonstration that RPS12 plays important roles in regulating the proliferation and migration of gastric cancer cells. S100A4 can mediate the effects of RPS12 as a downstream effector
Title: RPS12-specific shRNA inhibits the proliferation, migration of BGC823 gastric cancer cells with S100A4 as a downstream effector.

may be early molecular diagnostic marker for cervical squamous cell carcinoma
Title: Identification of molecular markers for the early detection of human squamous cell carcinoma of the uterine cervix.

The following RPS12 gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the RPS12 cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1⁺/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.

***CloneID	Accession No.	Definition	**Vector	*Turnaround time	Price (USD)
OHu30883	NM_001016.4 Latest version!	Homo sapiens ribosomal protein S12 (RPS12), mRNA.	pcDNA3.1-C-(k)DYK or customized vector	in pcDNA3.1-C-(k)DYK	$49.50-$69.30 $99.00
View Old Accession Versions >>
OHu30883	NM_001016.3	Homo sapiens ribosomal protein S12 (RPS12), mRNA.	pcDNA3.1-C-(k)DYK or customized vector	in pcDNA3.1-C-(k)DYK	$49.50-$69.30 $99.00
Hide Old Accession Versions >>

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** You may select a custom vector to replace pcDNA3.1+/C-(K)DYK after clone is added to cart.

** GenScript guarantees 100% sequence accuracy of all synthetic DNA constructs we deliver, but we do not guarantee protein expression in your experimental system. Protein expression is influenced by many factors that may vary between experiments or laboratories. In addition, please pay attention to the signal peptide, propeptide and transit peptide in target ORF, which may affect the choice of vector (N/C terminal tag vector).

***One clone ID might be correlated to multiple accession numbers, which share the same CDS sequence.

Reference Sequences (Refseq)

RPS12 ( NM_001016.3 ) cDNA ORF clone, Homo sapiens(human) -> NP_001007.2 Homo sapiens ribosomal protein S12 (RPS12), mRNA.

Price & Availability↑

CloneID	OHu30883
Clone ID Related Accession (Same CDS sequence)	NM_001016.3 , NM_001016.4
Accession Version	NM_001016.3	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 399bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2017-09-30
Organism	Homo sapiens(human)
Product	40S ribosomal protein S12
Comment	Comment: REVIEWED REFSEQ: This record has been curated by NCBI staff in collaboration with Francesco Amaldi. The reference sequence was derived from BQ276878.1 and BC095424.1. On Jul 26, 2005 this sequence version replaced NM_001016.2. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: BJ990964.1, BP272947.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA1965299, SAMEA1966682 [ECO:0000348] ##Evidence-Data-END## COMPLETENESS: full length.

ATGGCCGAGG AAGGCATTGC TGCTGGAGGT GTAATGGACG TTAATACTGC TTTACAAGAG 
GTTCTGAAGA CTGCCCTCAT CCACGATGGC CTAGCACGTG GAATTCGCGA AGCTGCCAAA 
GCCTTAGACA AGCGCCAAGC CCATCTTTGT GTGCTTGCAT CCAACTGTGA TGAGCCTATG 
TATGTCAAGT TGGTGGAGGC CCTTTGTGCT GAACACCAAA TCAACCTAAT TAAGGTTGAT 
GACAACAAGA AACTAGGAGA ATGGGTAGGC CTTTGTAAAA TTGACAGAGA GGGGAAACCC 
CGTAAAGTGG TTGGTTGCAG TTGTGTAGTA GTTAAGGACT ATGGCAAGGA GTCTCAGGCC 
AAGGATGTCA TTGAAGAGTA TTTCAAATGC AAGAAATGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_001007.2
CDS	83..481
Translation	MAEEGIAAGGVMDVNTALQEVLKTALIHDGLARGIREAAKALDKRQAHLCVLASNCDEPMYVKLVEALCAEHQINLIKVDDNKKLGEWVGLCKIDREGKPRKVVGCSCVVVKDYGKESQAKDVIEEYFKCKK

Target ORF information:

RefSeq Version	NM_001016.3
Organism	Homo sapiens(human)
Definition	Homo sapiens ribosomal protein S12 (RPS12), mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_001016.3

ORF Insert Sequence:

ATGGCCGAGG AAGGCATTGC TGCTGGAGGT GTAATGGACG TTAATACTGC TTTACAAGAG 
GTTCTGAAGA CTGCCCTCAT CCACGATGGC CTAGCACGTG GAATTCGCGA AGCTGCCAAA 
GCCTTAGACA AGCGCCAAGC CCATCTTTGT GTGCTTGCAT CCAACTGTGA TGAGCCTATG 
TATGTCAAGT TGGTGGAGGC CCTTTGTGCT GAACACCAAA TCAACCTAAT TAAGGTTGAT 
GACAACAAGA AACTAGGAGA ATGGGTAGGC CTTTGTAAAA TTGACAGAGA GGGGAAACCC 
CGTAAAGTGG TTGGTTGCAG TTGTGTAGTA GTTAAGGACT ATGGCAAGGA GTCTCAGGCC 
AAGGATGTCA TTGAAGAGTA TTTCAAATGC AAGAAATGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RPS12 ( NM_001016.4 ) cDNA ORF clone, Homo sapiens(human) -> NP_001007.2 Homo sapiens ribosomal protein S12 (RPS12), mRNA.

Price & Availability↑

CloneID	OHu30883
Clone ID Related Accession (Same CDS sequence)	NM_001016.3 , NM_001016.4
Accession Version	NM_001016.4 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 399bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-12-29
Organism	Homo sapiens(human)
Product	40S ribosomal protein S12
Comment	Comment: REVIEWED REFSEQ: This record has been curated by NCBI staff in collaboration with Francesco Amaldi. The reference sequence was derived from BQ276878.1 and BC095424.1. On Nov 22, 2018 this sequence version replaced NM_001016.3. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: BJ990964.1, BM742041.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA1965299, SAMEA1966682 [ECO:0000348] ##Evidence-Data-END## ##RefSeq-Attributes-START## MANE Ensembl match :: ENST00000230050.4/ ENSP00000230050.3 RefSeq Select criteria :: based on single protein-coding transcript ##RefSeq-Attributes-END## COMPLETENESS: full length.

ATGGCCGAGG AAGGCATTGC TGCTGGAGGT GTAATGGACG TTAATACTGC TTTACAAGAG 
GTTCTGAAGA CTGCCCTCAT CCACGATGGC CTAGCACGTG GAATTCGCGA AGCTGCCAAA 
GCCTTAGACA AGCGCCAAGC CCATCTTTGT GTGCTTGCAT CCAACTGTGA TGAGCCTATG 
TATGTCAAGT TGGTGGAGGC CCTTTGTGCT GAACACCAAA TCAACCTAAT TAAGGTTGAT 
GACAACAAGA AACTAGGAGA ATGGGTAGGC CTTTGTAAAA TTGACAGAGA GGGGAAACCC 
CGTAAAGTGG TTGGTTGCAG TTGTGTAGTA GTTAAGGACT ATGGCAAGGA GTCTCAGGCC 
AAGGATGTCA TTGAAGAGTA TTTCAAATGC AAGAAATGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_001007.2
CDS	83..481
Translation	MAEEGIAAGGVMDVNTALQEVLKTALIHDGLARGIREAAKALDKRQAHLCVLASNCDEPMYVKLVEALCAEHQINLIKVDDNKKLGEWVGLCKIDREGKPRKVVGCSCVVVKDYGKESQAKDVIEEYFKCKK

Target ORF information:

RefSeq Version	NM_001016.4
Organism	Homo sapiens(human)
Definition	Homo sapiens ribosomal protein S12 (RPS12), mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_001016.4

ORF Insert Sequence:

ATGGCCGAGG AAGGCATTGC TGCTGGAGGT GTAATGGACG TTAATACTGC TTTACAAGAG 
GTTCTGAAGA CTGCCCTCAT CCACGATGGC CTAGCACGTG GAATTCGCGA AGCTGCCAAA 
GCCTTAGACA AGCGCCAAGC CCATCTTTGT GTGCTTGCAT CCAACTGTGA TGAGCCTATG 
TATGTCAAGT TGGTGGAGGC CCTTTGTGCT GAACACCAAA TCAACCTAAT TAAGGTTGAT 
GACAACAAGA AACTAGGAGA ATGGGTAGGC CTTTGTAAAA TTGACAGAGA GGGGAAACCC 
CGTAAAGTGG TTGGTTGCAG TTGTGTAGTA GTTAAGGACT ATGGCAAGGA GTCTCAGGCC 
AAGGATGTCA TTGAAGAGTA TTTCAAATGC AAGAAATGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

PubMed

Analysis of rpsL and rrs genes mutations related to streptomycin resistance in Mdr and Xdr clinical isolates of Mycobacterium tuberculosis.
Tuberkuloz ve toraks63(4)235-42(2015)
Arjomandzadegan M,Gravand S

RPS12-specific shRNA inhibits the proliferation, migration of BGC823 gastric cancer cells with S100A4 as a downstream effector.
International journal of oncology42(5)1763-9(2013 May)
Chen D,Zhang R,Shen W,Fu H,Liu S,Sun K,Sun X

Insights into RNA biology from an atlas of mammalian mRNA-binding proteins.
Cell149(6)1393-406(2012 Jun)
Castello A,Fischer B,Eichelbaum K,Horos R,Beckmann BM,Strein C,Davey NE,Humphreys DT,Preiss T,Steinmetz LM,Krijgsveld J,Hentze MW

The mRNA-bound proteome and its global occupancy profile on protein-coding transcripts.
Molecular cell46(5)674-90(2012 Jun)
Baltz AG,Munschauer M,Schwanh?usser B,Vasile A,Murakawa Y,Schueler M,Youngs N,Penfold-Brown D,Drew K,Milek M,Wyler E,Bonneau R,Selbach M,Dieterich C,Landthaler M

A genome-wide association study for diabetic nephropathy genes in African Americans.
Kidney international79(5)563-72(2011 Mar)
McDonough CW,Palmer ND,Hicks PJ,Roh BH,An SS,Cooke JN,Hester JM,Wing MR,Bostrom MA,Rudock ME,Lewis JP,Talbert ME,Blevins RA,Lu L,Ng MC,Sale MM,Divers J,Langefeld CD,Freedman BI,Bowden DW

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RPS12 cDNA ORF clone, Homo sapiens(human)

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gRNAs

Related articles in PubMed

Target ORF information:

Target ORF information:

ORF Insert Sequence:

Target ORF information:

Target ORF information:

ORF Insert Sequence:

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