RPS4X cDNA ORF clone, Homo sapiens(human)

Gene
Clones
gRNAs

Summary

Gene Symbol	RPS4X
Entrez Gene ID	6191
Full Name	ribosomal protein S4, X-linked
Synonyms	CCG2,DXS306,RPS4,S4,SCAR,SCR10
General protein information	Preferred Names ribosomal protein S4, X-linked Names 40S ribosomal protein S4, X isoform cell cycle gene 2 ribosomal protein S4X isoform single copy abundant mRNA protein single-copy abundant mRNA small ribosomal subunit protein eS4
Gene Type	protein-coding
Organism	Homo sapiens(human)
Genome	Chromosome: X Map Location: Xq13.1
Summary	Cytoplasmic ribosomes, organelles that catalyze protein synthesis, consist of a small 40S subunit and a large 60S subunit. Together these subunits are composed of 4 RNA species and approximately 80 structurally distinct proteins. This gene encodes ribosomal protein S4, a component of the 40S subunit. Ribosomal protein S4 is the only ribosomal protein known to be encoded by more than one gene, namely this gene and ribosomal protein S4, Y-linked (RPS4Y). The 2 isoforms encoded by these genes are not identical, but are functionally equivalent. Ribosomal protein S4 belongs to the S4E family of ribosomal proteins. This gene is not subject to X-inactivation. It has been suggested that haploinsufficiency of the ribosomal protein S4 genes plays a role in Turner syndrome; however, this hypothesis is controversial. As is typical for genes encoding ribosomal proteins, there are multiple processed pseudogenes of this gene dispersed through the genome. [provided by RefSeq, Jul 2008].
Disorder MIM:	312760

mRNA and Protein(s)

mRNA	Protein	Name
NM_001007.5	NP_000998.1	40S ribosomal protein S4, X isoform
NM_001007.4	NP_000998.1	40S ribosomal protein S4, X isoform X isoform

Pathways from BioSystems

Homologies

Homo sapiens (human)	RPS4X	NP_000998.1
Bos taurus (cattle)	RPS4X	NP_001030522.1
Drosophila melanogaster (fruit fly)	RpS4	NP_729871.1
Schizosaccharomyces pombe (fission yeast)	rps403	NP_594174.1
Arabidopsis thaliana (thale cress)	AT2G17360	NP_565414.1
Oryza sativa (rice)	Os02g0105900	NP_001045624.1
Saccharomyces cerevisiae (baker's yeast)	RPS4B	NP_012073.1
Schizosaccharomyces pombe (fission yeast)	rps401	NP_596350.1
Magnaporthe oryzae (rice blast fungus)	MGG_02747	XP_003721009.1
Arabidopsis thaliana (thale cress)	AT5G58420	NP_200650.1
Pan troglodytes (chimpanzee)	RPS4X	XP_001139217.1
	LOC702514	XP_002805101.1
Caenorhabditis elegans (roundworm)	rps-4	NP_501103.1
Kluyveromyces lactis	KLLA0B03652g	XP_451697.1
Eremothecium gossypii	AGOS_ADL391C	NP_983705.1
Xenopus tropicalis (tropical clawed frog)	rps4x	NP_988912.1
Canis lupus familiaris (dog)	LOC102154781	XP_005620343.1
Gallus gallus (chicken)	RPS4X	NP_990439.1
Anopheles gambiae (African malaria mosquito)	AgaP_AGAP006871	XP_308886.4
Saccharomyces cerevisiae (baker's yeast)	RPS4A	NP_012679.3
Schizosaccharomyces pombe (fission yeast)	rps402	NP_595677.1
Neurospora crassa	NCU02181	XP_964251.2
Oryza sativa (rice)	Os01g0358400	NP_001043015.1
Oryza sativa (rice)	Os05g0368300	NP_001055342.1
Danio rerio (zebrafish)	rps4x	NP_001005589.1
Arabidopsis thaliana (thale cress)	AT5G07090	NP_568179.1

Gene Ontology
Bibliography

Related articles in PubMed

Low level of the X-linked ribosomal protein S4 in human urothelial carcinomas is associated with a poor prognosis.
Paquet ?R, Hovington H, Brisson H, Lacombe C, Larue H, T?tu B, Lacombe L, Fradet Y, Lebel M
Biomarkers in medicine9(3)187-97(2015)

Host factors that interact with the pestivirus N-terminal protease, Npro, are components of the ribonucleoprotein complex.
Jefferson M, Donaszi-Ivanov A, Pollen S, Dalmay T, Saalbach G, Powell PP
Journal of virology88(18)10340-53(2014 Sep)

In vitro selection of the 3'-untranslated regions of the human liver mRNA that bind to the HCV nonstructural protein 5B.
Yuhashi K, Ohnishi S, Kodama T, Koike K, Kanamori H
Virology450-45113-23(2014 Feb)

SILAC-based proteomics of human primary endothelial cell morphogenesis unveils tumor angiogenic markers.
Zanivan S, Maione F, Hein MY, Hern?ndez-Fernaud JR, Ostasiewicz P, Giraudo E, Mann M
Molecular & cellular proteomics : MCP12(12)3599-611(2013 Dec)

Low expression of the X-linked ribosomal protein S4 in human serous epithelial ovarian cancer is associated with a poor prognosis.
Tsofack SP, Meunier L, Sanchez L, Madore J, Provencher D, Mes-Masson AM, Lebel M
BMC cancer13303(2013 Jun)

GeneRIFs: Gene References Into Functions What's a GeneRIF?

Low RPS4X expression is associated with poor disease-specific and recurrence-free survival in bladder cancer
Title: Low level of the X-linked ribosomal protein S4 in human urothelial carcinomas is associated with a poor prognosis.

The 3'-UTR of liver mRNA of galectin-1 and RPS4X bind to the HCV NS5B.
Title: In vitro selection of the 3'-untranslated regions of the human liver mRNA that bind to the HCV nonstructural protein 5B.

levels of RPS4X could be a good indicator for resistance to platinum-based therapy and a prognostic marker for ovarian cancer
Title: Low expression of the X-linked ribosomal protein S4 in human serous epithelial ovarian cancer is associated with a poor prognosis.

The following RPS4X gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the RPS4X cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1⁺/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.

***CloneID	Accession No.	Definition	**Vector	*Turnaround time	Price (USD)
OHu22939	NM_001007.5 Latest version!	Homo sapiens ribosomal protein S4 X-linked (RPS4X), mRNA.	pcDNA3.1-C-(k)DYK or customized vector	in pcDNA3.1-C-(k)DYK	$49.50-$69.30 $99.00
View Old Accession Versions >>
OHu22939	NM_001007.4	Homo sapiens ribosomal protein S4, X-linked (RPS4X), mRNA.	pcDNA3.1-C-(k)DYK or customized vector	in pcDNA3.1-C-(k)DYK	$49.50-$69.30 $99.00
Hide Old Accession Versions >>

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** GenScript guarantees 100% sequence accuracy of all synthetic DNA constructs we deliver, but we do not guarantee protein expression in your experimental system. Protein expression is influenced by many factors that may vary between experiments or laboratories. In addition, please pay attention to the signal peptide, propeptide and transit peptide in target ORF, which may affect the choice of vector (N/C terminal tag vector).

***One clone ID might be correlated to multiple accession numbers, which share the same CDS sequence.

Reference Sequences (Refseq)

RPS4X ( NM_001007.5 ) cDNA ORF clone, Homo sapiens(human) -> NP_000998.1 Homo sapiens ribosomal protein S4 X-linked (RPS4X), mRNA.

Price & Availability↑

CloneID	OHu22939
Clone ID Related Accession (Same CDS sequence)	NM_001007.5 , NM_001007.4
Accession Version	NM_001007.5 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 792bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-10-24
Organism	Homo sapiens(human)
Product	40S ribosomal protein S4, X isoform
Comment	Comment: REVIEWED REFSEQ: This record has been curated by NCBI staff in collaboration with Francesco Amaldi. The reference sequence was derived from AL135749.3. This sequence is a reference standard in the RefSeqGene project. On Nov 23, 2018 this sequence version replaced NM_001007.4. Sequence Note: The RefSeq transcript and protein were derived from genomic sequence to make the sequence consistent with the reference genome assembly. The genomic coordinates used for the transcript record were based on alignments. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: SRR1163658.43996.1, SRR5189658.132986.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA2142348, SAMEA2151358 [ECO:0000348] ##Evidence-Data-END## ##RefSeq-Attributes-START## MANE Ensembl match :: ENST00000316084.10/ ENSP00000362744.4 RefSeq Select criteria :: based on single protein-coding transcript ##RefSeq-Attributes-END## COMPLETENESS: full length.

ATGGCTCGTG GTCCCAAGAA GCATCTGAAG CGGGTGGCAG CTCCAAAGCA TTGGATGCTG 
GATAAATTGA CCGGTGTGTT TGCTCCTCGT CCATCCACCG GTCCCCACAA GTTGAGAGAG 
TGTCTCCCCC TCATCATTTT CCTGAGGAAC AGACTTAAGT ATGCCCTGAC AGGAGATGAA 
GTAAAGAAGA TTTGCATGCA GCGGTTCATT AAAATCGATG GCAAGGTCCG AACTGATATA 
ACCTACCCTG CTGGATTCAT GGATGTCATC AGCATTGACA AGACGGGAGA GAATTTCCGT 
CTGATCTATG ACACCAAGGG TCGCTTTGCT GTACATCGTA TTACACCTGA GGAGGCCAAG 
TACAAGTTGT GCAAAGTGAG AAAGATCTTT GTGGGCACAA AAGGAATCCC TCATCTGGTG 
ACTCATGATG CCCGCACCAT CCGCTACCCC GATCCCCTCA TCAAGGTGAA TGATACCATT 
CAGATTGATT TGGAGACTGG CAAGATTACT GATTTCATCA AGTTCGACAC TGGTAACCTG 
TGTATGGTGA CTGGAGGTGC TAACCTAGGA AGAATTGGTG TGATCACCAA CAGAGAGAGG 
CACCCTGGAT CTTTTGACGT GGTTCACGTG AAAGATGCCA ATGGCAACAG CTTTGCCACT 
CGACTTTCCA ACATTTTTGT TATTGGCAAG GGCAACAAAC CATGGATTTC TCTTCCCCGA 
GGAAAGGGTA TCCGCCTCAC CATTGCTGAA GAGAGAGACA AAAGACTGGC GGCCAAACAG 
AGCAGTGGGT GA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_000998.1
CDS	54..845
Translation	MARGPKKHLKRVAAPKHWMLDKLTGVFAPRPSTGPHKLRECLPLIIFLRNRLKYALTGDEVKKICMQRFIKIDGKVRTDITYPAGFMDVISIDKTGENFRLIYDTKGRFAVHRITPEEAKYKLCKVRKIFVGTKGIPHLVTHDARTIRYPDPLIKVNDTIQIDLETGKITDFIKFDTGNLCMVTGGANLGRIGVITNRERHPGSFDVVHVKDANGNSFATRLSNIFVIGKGNKPWISLPRGKGIRLTIAEERDKRLAAKQSSG

Target ORF information:

RefSeq Version	NM_001007.5
Organism	Homo sapiens(human)
Definition	Homo sapiens ribosomal protein S4 X-linked (RPS4X), mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_001007.5

ORF Insert Sequence:

ATGGCTCGTG GTCCCAAGAA GCATCTGAAG CGGGTGGCAG CTCCAAAGCA TTGGATGCTG 
GATAAATTGA CCGGTGTGTT TGCTCCTCGT CCATCCACCG GTCCCCACAA GTTGAGAGAG 
TGTCTCCCCC TCATCATTTT CCTGAGGAAC AGACTTAAGT ATGCCCTGAC AGGAGATGAA 
GTAAAGAAGA TTTGCATGCA GCGGTTCATT AAAATCGATG GCAAGGTCCG AACTGATATA 
ACCTACCCTG CTGGATTCAT GGATGTCATC AGCATTGACA AGACGGGAGA GAATTTCCGT 
CTGATCTATG ACACCAAGGG TCGCTTTGCT GTACATCGTA TTACACCTGA GGAGGCCAAG 
TACAAGTTGT GCAAAGTGAG AAAGATCTTT GTGGGCACAA AAGGAATCCC TCATCTGGTG 
ACTCATGATG CCCGCACCAT CCGCTACCCC GATCCCCTCA TCAAGGTGAA TGATACCATT 
CAGATTGATT TGGAGACTGG CAAGATTACT GATTTCATCA AGTTCGACAC TGGTAACCTG 
TGTATGGTGA CTGGAGGTGC TAACCTAGGA AGAATTGGTG TGATCACCAA CAGAGAGAGG 
CACCCTGGAT CTTTTGACGT GGTTCACGTG AAAGATGCCA ATGGCAACAG CTTTGCCACT 
CGACTTTCCA ACATTTTTGT TATTGGCAAG GGCAACAAAC CATGGATTTC TCTTCCCCGA 
GGAAAGGGTA TCCGCCTCAC CATTGCTGAA GAGAGAGACA AAAGACTGGC GGCCAAACAG 
AGCAGTGGGT GA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RPS4X ( NM_001007.4 ) cDNA ORF clone, Homo sapiens(human) -> NP_000998.1 Homo sapiens ribosomal protein S4, X-linked (RPS4X), mRNA.

Price & Availability↑

CloneID	OHu22939
Clone ID Related Accession (Same CDS sequence)	NM_001007.5 , NM_001007.4
Accession Version	NM_001007.4	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 792bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2017-10-01
Organism	Homo sapiens(human)
Product	40S ribosomal protein S4, X isoform X isoform
Comment	Comment: REVIEWED REFSEQ: This record has been curated by NCBI staff in collaboration with Francesco Amaldi. The reference sequence was derived from AL135749.3. This sequence is a reference standard in the RefSeqGene project. On Aug 16, 2007 this sequence version replaced NM_001007.3. Sequence Note: The RefSeq transcript and protein were derived from genomic sequence to make the sequence consistent with the reference genome assembly. The genomic coordinates used for the transcript record were based on alignments. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: SRR1163658.184919.1, SRR1163655.490605.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA2142348, SAMEA2151358 [ECO:0000348] ##Evidence-Data-END## COMPLETENESS: full length.

ATGGCTCGTG GTCCCAAGAA GCATCTGAAG CGGGTGGCAG CTCCAAAGCA TTGGATGCTG 
GATAAATTGA CCGGTGTGTT TGCTCCTCGT CCATCCACCG GTCCCCACAA GTTGAGAGAG 
TGTCTCCCCC TCATCATTTT CCTGAGGAAC AGACTTAAGT ATGCCCTGAC AGGAGATGAA 
GTAAAGAAGA TTTGCATGCA GCGGTTCATT AAAATCGATG GCAAGGTCCG AACTGATATA 
ACCTACCCTG CTGGATTCAT GGATGTCATC AGCATTGACA AGACGGGAGA GAATTTCCGT 
CTGATCTATG ACACCAAGGG TCGCTTTGCT GTACATCGTA TTACACCTGA GGAGGCCAAG 
TACAAGTTGT GCAAAGTGAG AAAGATCTTT GTGGGCACAA AAGGAATCCC TCATCTGGTG 
ACTCATGATG CCCGCACCAT CCGCTACCCC GATCCCCTCA TCAAGGTGAA TGATACCATT 
CAGATTGATT TGGAGACTGG CAAGATTACT GATTTCATCA AGTTCGACAC TGGTAACCTG 
TGTATGGTGA CTGGAGGTGC TAACCTAGGA AGAATTGGTG TGATCACCAA CAGAGAGAGG 
CACCCTGGAT CTTTTGACGT GGTTCACGTG AAAGATGCCA ATGGCAACAG CTTTGCCACT 
CGACTTTCCA ACATTTTTGT TATTGGCAAG GGCAACAAAC CATGGATTTC TCTTCCCCGA 
GGAAAGGGTA TCCGCCTCAC CATTGCTGAA GAGAGAGACA AAAGACTGGC GGCCAAACAG 
AGCAGTGGGT GA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_000998.1
CDS	97..888
Translation	MARGPKKHLKRVAAPKHWMLDKLTGVFAPRPSTGPHKLRECLPLIIFLRNRLKYALTGDEVKKICMQRFIKIDGKVRTDITYPAGFMDVISIDKTGENFRLIYDTKGRFAVHRITPEEAKYKLCKVRKIFVGTKGIPHLVTHDARTIRYPDPLIKVNDTIQIDLETGKITDFIKFDTGNLCMVTGGANLGRIGVITNRERHPGSFDVVHVKDANGNSFATRLSNIFVIGKGNKPWISLPRGKGIRLTIAEERDKRLAAKQSSG

Target ORF information:

RefSeq Version	NM_001007.4
Organism	Homo sapiens(human)
Definition	Homo sapiens ribosomal protein S4, X-linked (RPS4X), mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_001007.4

ORF Insert Sequence:

ATGGCTCGTG GTCCCAAGAA GCATCTGAAG CGGGTGGCAG CTCCAAAGCA TTGGATGCTG 
GATAAATTGA CCGGTGTGTT TGCTCCTCGT CCATCCACCG GTCCCCACAA GTTGAGAGAG 
TGTCTCCCCC TCATCATTTT CCTGAGGAAC AGACTTAAGT ATGCCCTGAC AGGAGATGAA 
GTAAAGAAGA TTTGCATGCA GCGGTTCATT AAAATCGATG GCAAGGTCCG AACTGATATA 
ACCTACCCTG CTGGATTCAT GGATGTCATC AGCATTGACA AGACGGGAGA GAATTTCCGT 
CTGATCTATG ACACCAAGGG TCGCTTTGCT GTACATCGTA TTACACCTGA GGAGGCCAAG 
TACAAGTTGT GCAAAGTGAG AAAGATCTTT GTGGGCACAA AAGGAATCCC TCATCTGGTG 
ACTCATGATG CCCGCACCAT CCGCTACCCC GATCCCCTCA TCAAGGTGAA TGATACCATT 
CAGATTGATT TGGAGACTGG CAAGATTACT GATTTCATCA AGTTCGACAC TGGTAACCTG 
TGTATGGTGA CTGGAGGTGC TAACCTAGGA AGAATTGGTG TGATCACCAA CAGAGAGAGG 
CACCCTGGAT CTTTTGACGT GGTTCACGTG AAAGATGCCA ATGGCAACAG CTTTGCCACT 
CGACTTTCCA ACATTTTTGT TATTGGCAAG GGCAACAAAC CATGGATTTC TCTTCCCCGA 
GGAAAGGGTA TCCGCCTCAC CATTGCTGAA GAGAGAGACA AAAGACTGGC GGCCAAACAG 
AGCAGTGGGT GA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

PubMed

Low level of the X-linked ribosomal protein S4 in human urothelial carcinomas is associated with a poor prognosis.
Biomarkers in medicine9(3)187-97(2015)
Paquet ?R,Hovington H,Brisson H,Lacombe C,Larue H,T?tu B,Lacombe L,Fradet Y,Lebel M

Host factors that interact with the pestivirus N-terminal protease, Npro, are components of the ribonucleoprotein complex.
Journal of virology88(18)10340-53(2014 Sep)
Jefferson M,Donaszi-Ivanov A,Pollen S,Dalmay T,Saalbach G,Powell PP

In vitro selection of the 3'-untranslated regions of the human liver mRNA that bind to the HCV nonstructural protein 5B.
Virology450-45113-23(2014 Feb)
Yuhashi K,Ohnishi S,Kodama T,Koike K,Kanamori H

SILAC-based proteomics of human primary endothelial cell morphogenesis unveils tumor angiogenic markers.
Molecular & cellular proteomics : MCP12(12)3599-611(2013 Dec)
Zanivan S,Maione F,Hein MY,Hern?ndez-Fernaud JR,Ostasiewicz P,Giraudo E,Mann M

Low expression of the X-linked ribosomal protein S4 in human serous epithelial ovarian cancer is associated with a poor prognosis.
BMC cancer13303(2013 Jun)
Tsofack SP,Meunier L,Sanchez L,Madore J,Provencher D,Mes-Masson AM,Lebel M

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RPS4X cDNA ORF clone, Homo sapiens(human)

Gene

Clones

gRNAs

Related articles in PubMed

Target ORF information:

Target ORF information:

ORF Insert Sequence:

Target ORF information:

Target ORF information:

ORF Insert Sequence:

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