RPN1 cDNA ORF clone, Homo sapiens(human)

Gene
Clones
gRNAs

Summary

Gene Symbol	RPN1
Entrez Gene ID	6184
Full Name	ribophorin I
Synonyms	OST1,RBPH1
General protein information	Preferred Names ribophorin I Names dolichyl-diphosphooligosaccharide--protein glycosyltransferase subunit 1 RPN-I dolichyl-diphosphooligosaccharide-protein glycosyltransferase 67 kDa subunit oligosaccharyltransferase 1 homolog oligosaccharyltransferase complex subunit (non-catalytic) ribophorin-1
Gene Type	protein-coding
Organism	Homo sapiens(human)
Genome	Chromosome: 3 Map Location: 3q21.3
Summary	This gene encodes a type I integral membrane protein found only in the rough endoplasmic reticulum. The encoded protein is part of an N-oligosaccharyl transferase complex that links high mannose oligosaccharides to asparagine residues found in the Asn-X-Ser/Thr consensus motif of nascent polypeptide chains. This protein forms part of the regulatory subunit of the 26S proteasome and may mediate binding of ubiquitin-like domains to this proteasome. [provided by RefSeq, Jul 2008].
Disorder MIM:	180470

mRNA and Protein(s)

mRNA	Protein	Name
NM_002950.4	NP_002941.1	dolichyl-diphosphooligosaccharide--protein glycosyltransferase subunit 1 precursor
NM_002950.3	NP_002941.1	dolichyl-diphosphooligosaccharide--protein glycosyltransferase subunit 1 precursor

Pathways from BioSystems

Homologies

Homo sapiens (human)	RPN1	NP_002941.1
Bos taurus (cattle)	RPN1	NP_001076074.1
Caenorhabditis elegans (roundworm)	ribo-1	NP_501065.2
Pan troglodytes (chimpanzee)	RPN1	XP_516729.2
	RPN1	XP_001097494.1
Rattus norvegicus (Norway rat)	Rpn1	NP_037199.1
Drosophila melanogaster (fruit fly)	CG33303	NP_995680.1
Oryza sativa (rice)	Os05g0301500	NP_001055134.1
Anopheles gambiae (African malaria mosquito)	AgaP_AGAP010174	XP_319348.4
Arabidopsis thaliana (thale cress)	AT1G76400	NP_177766.1
Canis lupus familiaris (dog)	RPN1	XP_848830.1
Mus musculus (house mouse)	Rpn1	NP_598694.3
Xenopus tropicalis (tropical clawed frog)	rpn1	NP_989394.1
Gallus gallus (chicken)	RPN1	XP_414360.4
Danio rerio (zebrafish)	rpn1	NP_922916.1

Gene Ontology
Bibliography

Related articles in PubMed

Association of malectin with ribophorin I is crucial for attenuation of misfolded glycoprotein secretion.
Takeda K, Qin SY, Matsumoto N, Yamamoto K
Biochemical and biophysical research communications454(3)436-40(2014 11)

SILAC-based proteomics of human primary endothelial cell morphogenesis unveils tumor angiogenic markers.
Zanivan S, Maione F, Hein MY, Hern?ndez-Fernaud JR, Ostasiewicz P, Giraudo E, Mann M
Molecular & cellular proteomics : MCP12(12)3599-611(2013 Dec)

Genetic variation associated with circulating monocyte count in the eMERGE Network.
Crosslin DR, McDavid A, Weston N, Zheng X, Hart E, de Andrade M, Kullo IJ, McCarty CA, Doheny KF, Pugh E, Kho A, Hayes MG, Ritchie MD, Saip A, Crawford DC, Crane PK, Newton K, Carrell DS, Gallego CJ, Nalls MA, Li R, Mirel DB, Crenshaw A, Couper DJ, Tanaka T, van Rooij FJ, Chen MH, Smith AV, Zakai NA, Yango Q, Garcia M, Liu Y, Lumley T, Folsom AR, Reiner AP, Felix JF, Dehghan A, Wilson JG, Bis JC, Fox CS, Glazer NL, Cupples LA, Coresh J, Eiriksdottir G, Gudnason V, Bandinelli S, Frayling TM, Chakravarti A, van Duijn CM, Melzer D, Levy D, Boerwinkle E, Singleton AB, Hernandez DG, Longo DL, Witteman JC, Psaty BM, Ferrucci L, Harris TB, O'Donnell CJ, Ganesh SK, , Larson EB, Carlson CS, Jarvik GP,
Human molecular genetics22(10)2119-27(2013 May)

Malectin forms a complex with ribophorin I for enhanced association with misfolded glycoproteins.
Qin SY, Hu D, Matsumoto K, Takeda K, Matsumoto N, Yamaguchi Y, Yamamoto K
The Journal of biological chemistry287(45)38080-9(2012 Nov)

GeneRIFs: Gene References Into Functions What's a GeneRIF?

These results clearly demonstrate that the association of malectin with ribophorin I is required to capture misfolded alpha1-antitrypsin and direct them to the degradation pathway.
Title: Association of malectin with ribophorin I is crucial for attenuation of misfolded glycoprotein secretion.

Data indicate that malectin functions by forming a complex with ribophorin I.
Title: Malectin forms a complex with ribophorin I for enhanced association with misfolded glycoproteins.

Observational study of gene-disease association. (HuGE Navigator)
Title: Polymorphisms in mitochondrial genes and prostate cancer risk.

ribophorin I can regulate the delivery of precursor proteins to the OST complex by capturing substrates and presenting them to the catalytic core.
Title: Ribophorin I regulates substrate delivery to the oligosaccharyltransferase core.

The following RPN1 gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the RPN1 cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1⁺/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.

***CloneID	Accession No.	Definition	**Vector	*Turnaround time	Price (USD)
OHu25716	NM_002950.4 Latest version!	Homo sapiens ribophorin I (RPN1), mRNA.	pcDNA3.1-C-(k)DYK or customized vector	in pcDNA3.1-C-(k)DYK	$189.50-$265.30 $379.00
View Old Accession Versions >>
OHu25716	NM_002950.3	Homo sapiens ribophorin I (RPN1), mRNA.	pcDNA3.1-C-(k)DYK or customized vector	in pcDNA3.1-C-(k)DYK	$189.50-$265.30 $379.00
Hide Old Accession Versions >>

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** GenScript guarantees 100% sequence accuracy of all synthetic DNA constructs we deliver, but we do not guarantee protein expression in your experimental system. Protein expression is influenced by many factors that may vary between experiments or laboratories. In addition, please pay attention to the signal peptide, propeptide and transit peptide in target ORF, which may affect the choice of vector (N/C terminal tag vector).

***One clone ID might be correlated to multiple accession numbers, which share the same CDS sequence.

Reference Sequences (Refseq)

RPN1 ( NM_002950.4 ) cDNA ORF clone, Homo sapiens(human) -> NP_002941.1 Homo sapiens ribophorin I (RPN1), mRNA.

Price & Availability↑

CloneID	OHu25716
Clone ID Related Accession (Same CDS sequence)	NM_002950.4 , NM_002950.3
Accession Version	NM_002950.4 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 1824bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-10-23
Organism	Homo sapiens(human)
Product	dolichyl-diphosphooligosaccharide--protein glycosyltransferase subunit 1 precursor
Comment	Comment: REVIEWED REFSEQ: This record has been curated by NCBI staff. The reference sequence was derived from BC010839.1 and AC079945.21. On Nov 22, 2018 this sequence version replaced NM_002950.3. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: SRR5189658.160778.1, BC010839.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA1966682, SAMEA1968968 [ECO:0000348] ##Evidence-Data-END## ##RefSeq-Attributes-START## MANE Ensembl match :: ENST00000296255.8/ ENSP00000296255.3 RefSeq Select criteria :: based on single protein-coding transcript ##RefSeq-Attributes-END## COMPLETENESS: full length.

ATGGAGGCGC CAGCCGCCGG CTTGTTTCTG CTCCTGTTGC TTGGGACTTG GGCCCCGGCG 
CCGGGCAGCG CCTCCTCCGA GGCACCGCCG CTGATCAATG AGGACGTGAA GCGCACAGTG 
GACCTAAGCA GCCACCTGGC TAAGGTGACG GCCGAGGTGG TCCTGGCGCA CCTGGGCGGC 
GGCTCCACGT CCCGAGCTAC CTCTTTCCTG CTGGCTTTGG AGCCTGAGCT CGAGGCCCGG 
CTGGCGCACC TGGGCGTGCA GGTAAAGGGA GAAGATGAGG AAGAGAACAA TTTGGAAGTA 
CGTGAAACCA AAATTAAGGG TAAAAGTGGG AGATTCTTCA CAGTCAAGCT CCCAGTTGCT 
CTTGATCCTG GGGCCAAGAT TTCAGTCATT GTGGAAACAG TCTACACCCA TGTGCTTCAT 
CCGTATCCAA CCCAGATCAC CCAGTCAGAG AAACAGTTTG TGGTGTTTGA GGGGAACCAT 
TATTTCTACT CTCCCTATCC AACGAAGACA CAAACCATGC GTGTGAAGCT TGCCTCTCGA 
AATGTGGAGA GCTACACCAA GCTGGGGAAC CCCACGCGCT CTGAGGACCT ACTGGATTAT 
GGGCCTTTCA GAGATGTGCC TGCCTATAGT CAGGATACTT TTAAAGTACA TTATGAGAAC 
AACAGCCCTT TCCTGACCAT CACCAGCATG ACCCGAGTCA TTGAAGTCTC TCACTGGGGT 
AATATTGCTG TGGAAGAAAA TGTGGACTTA AAGCACACAG GAGCTGTGCT TAAGGGGCCT 
TTCTCACGCT ATGATTACCA GAGACAGCCA GATAGTGGAA TATCCTCCAT CCGTTCTTTT 
AAGACCATCC TTCCTGCTGC TGCCCAGGAT GTTTATTACC GGGATGAGAT TGGCAATGTT 
TCTACCAGCC ACCTCCTTAT TTTGGATGAC TCTGTAGAGA TGGAAATCCG GCCTCGCTTC 
CCTCTCTTTG GCGGGTGGAA GACCCATTAC ATCGTTGGCT ACAACCTCCC AAGCTATGAG 
TACCTCTATA ATTTGGGTGA CCAGTATGCA CTGAAGATGA GGTTTGTGGA CCATGTGTTT 
GATGAACAAG TGATAGATTC TCTGACTGTG AAGATCATCC TGCCTGAAGG AGCCAAGAAC 
ATTGAAATTG ATAGTCCCTA TGAAATCAGC CGTGCCCCAG ATGAGCTGCA CTACACCTAT 
CTGGACACAT TTGGCCGCCC TGTGATTGTT GCCTACAAGA AAAATCTGGT AGAACAGCAC 
ATTCAGGACA TTGTGGTCCA CTACACGTTC AACAAGGTGC TCATGCTGCA GGAGCCCCTG 
CTGGTGGTGG CGGCCTTCTA CATCCTGTTC TTCACCGTTA TCATCTATGT TCGGCTGGAC 
TTCTCCATCA CCAAGGATCC AGCCGCAGAA GCCAGGATGA AGGTAGCCTG CATCACAGAG 
CAGGTCTTGA CCCTGGTCAA CAAGAGAATA GGCCTTTACC GTCACTTTGA CGAGACCGTC 
AATAGGTACA AGCAATCCCG GGACATCTCC ACCCTCAACA GTGGCAAGAA GAGCCTGGAG 
ACTGAACACA AGGCCTTGAC CAGTGAGATT GCACTGCTGC AGTCCAGGCT GAAGACAGAG 
GGCTCTGATC TGTGCGACAG AGTGAGCGAA ATGCAGAAGC TGGATGCACA GGTCAAGGAG 
CTGGTGCTGA AGTCGGCGGT GGAGGCTGAG CGCCTGGTGG CTGGCAAGCT CAAGAAAGAC 
ACGTACATTG AGAATGAGAA GCTCATCTCA GGAAAGCGCC AGGAGCTGGT CACCAAGATC 
GACCACATCC TGGATGCCCT GTAG

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_002941.1
CDS	19..1842
Translation	MEAPAAGLFLLLLLGTWAPAPGSASSEAPPLINEDVKRTVDLSSHLAKVTAEVVLAHLGGGSTSRATSFLLALEPELEARLAHLGVQVKGEDEEENNLEVRETKIKGKSGRFFTVKLPVALDPGAKISVIVETVYTHVLHPYPTQITQSEKQFVVFEGNHYFYSPYPTKTQTMRVKLASRNVESYTKLGNPTRSEDLLDYGPFRDVPAYSQDTFKVHYENNSPFLTITSMTRVIEVSHWGNIAVEENVDLKHTGAVLKGPFSRYDYQRQPDSGISSIRSFKTILPAAAQDVYYRDEIGNVSTSHLLILDDSVEMEIRPRFPLFGGWKTHYIVGYNLPSYEYLYNLGDQYALKMRFVDHVFDEQVIDSLTVKIILPEGAKNIEIDSPYEISRAPDELHYTYLDTFGRPVIVAYKKNLVEQHIQDIVVHYTFNKVLMLQEPLLVVAAFYILFFTVIIYVRLDFSITKDPAAEARMKVACITEQVLTLVNKRIGLYRHFDETVNRYKQSRDISTLNSGKKSLETEHKALTSEIALLQSRLKTEGSDLCDRVSEMQKLDAQVKELVLKSAVEAERLVAGKLKKDTYIENEKLISGKRQELVTKIDHILDAL

Target ORF information:

RefSeq Version	NM_002950.4
Organism	Homo sapiens(human)
Definition	Homo sapiens ribophorin I (RPN1), mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_002950.4

ORF Insert Sequence:

ATGGAGGCGC CAGCCGCCGG CTTGTTTCTG CTCCTGTTGC TTGGGACTTG GGCCCCGGCG 
CCGGGCAGCG CCTCCTCCGA GGCACCGCCG CTGATCAATG AGGACGTGAA GCGCACAGTG 
GACCTAAGCA GCCACCTGGC TAAGGTGACG GCCGAGGTGG TCCTGGCGCA CCTGGGCGGC 
GGCTCCACGT CCCGAGCTAC CTCTTTCCTG CTGGCTTTGG AGCCTGAGCT CGAGGCCCGG 
CTGGCGCACC TGGGCGTGCA GGTAAAGGGA GAAGATGAGG AAGAGAACAA TTTGGAAGTA 
CGTGAAACCA AAATTAAGGG TAAAAGTGGG AGATTCTTCA CAGTCAAGCT CCCAGTTGCT 
CTTGATCCTG GGGCCAAGAT TTCAGTCATT GTGGAAACAG TCTACACCCA TGTGCTTCAT 
CCGTATCCAA CCCAGATCAC CCAGTCAGAG AAACAGTTTG TGGTGTTTGA GGGGAACCAT 
TATTTCTACT CTCCCTATCC AACGAAGACA CAAACCATGC GTGTGAAGCT TGCCTCTCGA 
AATGTGGAGA GCTACACCAA GCTGGGGAAC CCCACGCGCT CTGAGGACCT ACTGGATTAT 
GGGCCTTTCA GAGATGTGCC TGCCTATAGT CAGGATACTT TTAAAGTACA TTATGAGAAC 
AACAGCCCTT TCCTGACCAT CACCAGCATG ACCCGAGTCA TTGAAGTCTC TCACTGGGGT 
AATATTGCTG TGGAAGAAAA TGTGGACTTA AAGCACACAG GAGCTGTGCT TAAGGGGCCT 
TTCTCACGCT ATGATTACCA GAGACAGCCA GATAGTGGAA TATCCTCCAT CCGTTCTTTT 
AAGACCATCC TTCCTGCTGC TGCCCAGGAT GTTTATTACC GGGATGAGAT TGGCAATGTT 
TCTACCAGCC ACCTCCTTAT TTTGGATGAC TCTGTAGAGA TGGAAATCCG GCCTCGCTTC 
CCTCTCTTTG GCGGGTGGAA GACCCATTAC ATCGTTGGCT ACAACCTCCC AAGCTATGAG 
TACCTCTATA ATTTGGGTGA CCAGTATGCA CTGAAGATGA GGTTTGTGGA CCATGTGTTT 
GATGAACAAG TGATAGATTC TCTGACTGTG AAGATCATCC TGCCTGAAGG AGCCAAGAAC 
ATTGAAATTG ATAGTCCCTA TGAAATCAGC CGTGCCCCAG ATGAGCTGCA CTACACCTAT 
CTGGACACAT TTGGCCGCCC TGTGATTGTT GCCTACAAGA AAAATCTGGT AGAACAGCAC 
ATTCAGGACA TTGTGGTCCA CTACACGTTC AACAAGGTGC TCATGCTGCA GGAGCCCCTG 
CTGGTGGTGG CGGCCTTCTA CATCCTGTTC TTCACCGTTA TCATCTATGT TCGGCTGGAC 
TTCTCCATCA CCAAGGATCC AGCCGCAGAA GCCAGGATGA AGGTAGCCTG CATCACAGAG 
CAGGTCTTGA CCCTGGTCAA CAAGAGAATA GGCCTTTACC GTCACTTTGA CGAGACCGTC 
AATAGGTACA AGCAATCCCG GGACATCTCC ACCCTCAACA GTGGCAAGAA GAGCCTGGAG 
ACTGAACACA AGGCCTTGAC CAGTGAGATT GCACTGCTGC AGTCCAGGCT GAAGACAGAG 
GGCTCTGATC TGTGCGACAG AGTGAGCGAA ATGCAGAAGC TGGATGCACA GGTCAAGGAG 
CTGGTGCTGA AGTCGGCGGT GGAGGCTGAG CGCCTGGTGG CTGGCAAGCT CAAGAAAGAC 
ACGTACATTG AGAATGAGAA GCTCATCTCA GGAAAGCGCC AGGAGCTGGT CACCAAGATC 
GACCACATCC TGGATGCCCT GTAG

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RPN1 ( NM_002950.3 ) cDNA ORF clone, Homo sapiens(human) -> NP_002941.1 Homo sapiens ribophorin I (RPN1), mRNA.

Price & Availability↑

CloneID	OHu25716
Clone ID Related Accession (Same CDS sequence)	NM_002950.4 , NM_002950.3
Accession Version	NM_002950.3	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 1824bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2017-09-24
Organism	Homo sapiens(human)
Product	dolichyl-diphosphooligosaccharide--protein glycosyltransferase subunit 1 precursor
Comment	Comment: REVIEWED REFSEQ: This record has been curated by NCBI staff. The reference sequence was derived from BG720812.1, BC010839.1 and AC079945.21. On Apr 19, 2005 this sequence version replaced NM_002950.2. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: BC010839.1, AK223595.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA1966682, SAMEA1968968 [ECO:0000348] ##Evidence-Data-END## COMPLETENESS: complete on the 3' end.

ATGGAGGCGC CAGCCGCCGG CTTGTTTCTG CTCCTGTTGC TTGGGACTTG GGCCCCGGCG 
CCGGGCAGCG CCTCCTCCGA GGCACCGCCG CTGATCAATG AGGACGTGAA GCGCACAGTG 
GACCTAAGCA GCCACCTGGC TAAGGTGACG GCCGAGGTGG TCCTGGCGCA CCTGGGCGGC 
GGCTCCACGT CCCGAGCTAC CTCTTTCCTG CTGGCTTTGG AGCCTGAGCT CGAGGCCCGG 
CTGGCGCACC TGGGCGTGCA GGTAAAGGGA GAAGATGAGG AAGAGAACAA TTTGGAAGTA 
CGTGAAACCA AAATTAAGGG TAAAAGTGGG AGATTCTTCA CAGTCAAGCT CCCAGTTGCT 
CTTGATCCTG GGGCCAAGAT TTCAGTCATT GTGGAAACAG TCTACACCCA TGTGCTTCAT 
CCGTATCCAA CCCAGATCAC CCAGTCAGAG AAACAGTTTG TGGTGTTTGA GGGGAACCAT 
TATTTCTACT CTCCCTATCC AACGAAGACA CAAACCATGC GTGTGAAGCT TGCCTCTCGA 
AATGTGGAGA GCTACACCAA GCTGGGGAAC CCCACGCGCT CTGAGGACCT ACTGGATTAT 
GGGCCTTTCA GAGATGTGCC TGCCTATAGT CAGGATACTT TTAAAGTACA TTATGAGAAC 
AACAGCCCTT TCCTGACCAT CACCAGCATG ACCCGAGTCA TTGAAGTCTC TCACTGGGGT 
AATATTGCTG TGGAAGAAAA TGTGGACTTA AAGCACACAG GAGCTGTGCT TAAGGGGCCT 
TTCTCACGCT ATGATTACCA GAGACAGCCA GATAGTGGAA TATCCTCCAT CCGTTCTTTT 
AAGACCATCC TTCCTGCTGC TGCCCAGGAT GTTTATTACC GGGATGAGAT TGGCAATGTT 
TCTACCAGCC ACCTCCTTAT TTTGGATGAC TCTGTAGAGA TGGAAATCCG GCCTCGCTTC 
CCTCTCTTTG GCGGGTGGAA GACCCATTAC ATCGTTGGCT ACAACCTCCC AAGCTATGAG 
TACCTCTATA ATTTGGGTGA CCAGTATGCA CTGAAGATGA GGTTTGTGGA CCATGTGTTT 
GATGAACAAG TGATAGATTC TCTGACTGTG AAGATCATCC TGCCTGAAGG AGCCAAGAAC 
ATTGAAATTG ATAGTCCCTA TGAAATCAGC CGTGCCCCAG ATGAGCTGCA CTACACCTAT 
CTGGACACAT TTGGCCGCCC TGTGATTGTT GCCTACAAGA AAAATCTGGT AGAACAGCAC 
ATTCAGGACA TTGTGGTCCA CTACACGTTC AACAAGGTGC TCATGCTGCA GGAGCCCCTG 
CTGGTGGTGG CGGCCTTCTA CATCCTGTTC TTCACCGTTA TCATCTATGT TCGGCTGGAC 
TTCTCCATCA CCAAGGATCC AGCCGCAGAA GCCAGGATGA AGGTAGCCTG CATCACAGAG 
CAGGTCTTGA CCCTGGTCAA CAAGAGAATA GGCCTTTACC GTCACTTTGA CGAGACCGTC 
AATAGGTACA AGCAATCCCG GGACATCTCC ACCCTCAACA GTGGCAAGAA GAGCCTGGAG 
ACTGAACACA AGGCCTTGAC CAGTGAGATT GCACTGCTGC AGTCCAGGCT GAAGACAGAG 
GGCTCTGATC TGTGCGACAG AGTGAGCGAA ATGCAGAAGC TGGATGCACA GGTCAAGGAG 
CTGGTGCTGA AGTCGGCGGT GGAGGCTGAG CGCCTGGTGG CTGGCAAGCT CAAGAAAGAC 
ACGTACATTG AGAATGAGAA GCTCATCTCA GGAAAGCGCC AGGAGCTGGT CACCAAGATC 
GACCACATCC TGGATGCCCT GTAG

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_002941.1
CDS	77..1900
Translation	MEAPAAGLFLLLLLGTWAPAPGSASSEAPPLINEDVKRTVDLSSHLAKVTAEVVLAHLGGGSTSRATSFLLALEPELEARLAHLGVQVKGEDEEENNLEVRETKIKGKSGRFFTVKLPVALDPGAKISVIVETVYTHVLHPYPTQITQSEKQFVVFEGNHYFYSPYPTKTQTMRVKLASRNVESYTKLGNPTRSEDLLDYGPFRDVPAYSQDTFKVHYENNSPFLTITSMTRVIEVSHWGNIAVEENVDLKHTGAVLKGPFSRYDYQRQPDSGISSIRSFKTILPAAAQDVYYRDEIGNVSTSHLLILDDSVEMEIRPRFPLFGGWKTHYIVGYNLPSYEYLYNLGDQYALKMRFVDHVFDEQVIDSLTVKIILPEGAKNIEIDSPYEISRAPDELHYTYLDTFGRPVIVAYKKNLVEQHIQDIVVHYTFNKVLMLQEPLLVVAAFYILFFTVIIYVRLDFSITKDPAAEARMKVACITEQVLTLVNKRIGLYRHFDETVNRYKQSRDISTLNSGKKSLETEHKALTSEIALLQSRLKTEGSDLCDRVSEMQKLDAQVKELVLKSAVEAERLVAGKLKKDTYIENEKLISGKRQELVTKIDHILDAL

Target ORF information:

RefSeq Version	NM_002950.3
Organism	Homo sapiens(human)
Definition	Homo sapiens ribophorin I (RPN1), mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_002950.3

ORF Insert Sequence:

ATGGAGGCGC CAGCCGCCGG CTTGTTTCTG CTCCTGTTGC TTGGGACTTG GGCCCCGGCG 
CCGGGCAGCG CCTCCTCCGA GGCACCGCCG CTGATCAATG AGGACGTGAA GCGCACAGTG 
GACCTAAGCA GCCACCTGGC TAAGGTGACG GCCGAGGTGG TCCTGGCGCA CCTGGGCGGC 
GGCTCCACGT CCCGAGCTAC CTCTTTCCTG CTGGCTTTGG AGCCTGAGCT CGAGGCCCGG 
CTGGCGCACC TGGGCGTGCA GGTAAAGGGA GAAGATGAGG AAGAGAACAA TTTGGAAGTA 
CGTGAAACCA AAATTAAGGG TAAAAGTGGG AGATTCTTCA CAGTCAAGCT CCCAGTTGCT 
CTTGATCCTG GGGCCAAGAT TTCAGTCATT GTGGAAACAG TCTACACCCA TGTGCTTCAT 
CCGTATCCAA CCCAGATCAC CCAGTCAGAG AAACAGTTTG TGGTGTTTGA GGGGAACCAT 
TATTTCTACT CTCCCTATCC AACGAAGACA CAAACCATGC GTGTGAAGCT TGCCTCTCGA 
AATGTGGAGA GCTACACCAA GCTGGGGAAC CCCACGCGCT CTGAGGACCT ACTGGATTAT 
GGGCCTTTCA GAGATGTGCC TGCCTATAGT CAGGATACTT TTAAAGTACA TTATGAGAAC 
AACAGCCCTT TCCTGACCAT CACCAGCATG ACCCGAGTCA TTGAAGTCTC TCACTGGGGT 
AATATTGCTG TGGAAGAAAA TGTGGACTTA AAGCACACAG GAGCTGTGCT TAAGGGGCCT 
TTCTCACGCT ATGATTACCA GAGACAGCCA GATAGTGGAA TATCCTCCAT CCGTTCTTTT 
AAGACCATCC TTCCTGCTGC TGCCCAGGAT GTTTATTACC GGGATGAGAT TGGCAATGTT 
TCTACCAGCC ACCTCCTTAT TTTGGATGAC TCTGTAGAGA TGGAAATCCG GCCTCGCTTC 
CCTCTCTTTG GCGGGTGGAA GACCCATTAC ATCGTTGGCT ACAACCTCCC AAGCTATGAG 
TACCTCTATA ATTTGGGTGA CCAGTATGCA CTGAAGATGA GGTTTGTGGA CCATGTGTTT 
GATGAACAAG TGATAGATTC TCTGACTGTG AAGATCATCC TGCCTGAAGG AGCCAAGAAC 
ATTGAAATTG ATAGTCCCTA TGAAATCAGC CGTGCCCCAG ATGAGCTGCA CTACACCTAT 
CTGGACACAT TTGGCCGCCC TGTGATTGTT GCCTACAAGA AAAATCTGGT AGAACAGCAC 
ATTCAGGACA TTGTGGTCCA CTACACGTTC AACAAGGTGC TCATGCTGCA GGAGCCCCTG 
CTGGTGGTGG CGGCCTTCTA CATCCTGTTC TTCACCGTTA TCATCTATGT TCGGCTGGAC 
TTCTCCATCA CCAAGGATCC AGCCGCAGAA GCCAGGATGA AGGTAGCCTG CATCACAGAG 
CAGGTCTTGA CCCTGGTCAA CAAGAGAATA GGCCTTTACC GTCACTTTGA CGAGACCGTC 
AATAGGTACA AGCAATCCCG GGACATCTCC ACCCTCAACA GTGGCAAGAA GAGCCTGGAG 
ACTGAACACA AGGCCTTGAC CAGTGAGATT GCACTGCTGC AGTCCAGGCT GAAGACAGAG 
GGCTCTGATC TGTGCGACAG AGTGAGCGAA ATGCAGAAGC TGGATGCACA GGTCAAGGAG 
CTGGTGCTGA AGTCGGCGGT GGAGGCTGAG CGCCTGGTGG CTGGCAAGCT CAAGAAAGAC 
ACGTACATTG AGAATGAGAA GCTCATCTCA GGAAAGCGCC AGGAGCTGGT CACCAAGATC 
GACCACATCC TGGATGCCCT GTAG

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

PubMed

Association of malectin with ribophorin I is crucial for attenuation of misfolded glycoprotein secretion.
Biochemical and biophysical research communications454(3)436-40(2014 11)
Takeda K,Qin SY,Matsumoto N,Yamamoto K

SILAC-based proteomics of human primary endothelial cell morphogenesis unveils tumor angiogenic markers.
Molecular & cellular proteomics : MCP12(12)3599-611(2013 Dec)
Zanivan S,Maione F,Hein MY,Hern?ndez-Fernaud JR,Ostasiewicz P,Giraudo E,Mann M

Genetic variation associated with circulating monocyte count in the eMERGE Network.
Human molecular genetics22(10)2119-27(2013 May)
Crosslin DR,McDavid A,Weston N,Zheng X,Hart E,de Andrade M,Kullo IJ,McCarty CA,Doheny KF,Pugh E,Kho A,Hayes MG,Ritchie MD,Saip A,Crawford DC,Crane PK,Newton K,Carrell DS,Gallego CJ,Nalls MA,Li R,Mirel DB,Crenshaw A,Couper DJ,Tanaka T,van Rooij FJ,Chen MH,Smith AV,Zakai NA,Yango Q,Garcia M,Liu Y,Lumley T,Folsom AR,Reiner AP,Felix JF,Dehghan A,Wilson JG,Bis JC,Fox CS,Glazer NL,Cupples LA,Coresh J,Eiriksdottir G,Gudnason V,Bandinelli S,Frayling TM,Chakravarti A,van Duijn CM,Melzer D,Levy D,Boerwinkle E,Singleton AB,Hernandez DG,Longo DL,Witteman JC,Psaty BM,Ferrucci L,Harris TB,O'Donnell CJ,Ganesh SK,,Larson EB,Carlson CS,Jarvik GP,

Malectin forms a complex with ribophorin I for enhanced association with misfolded glycoproteins.
The Journal of biological chemistry287(45)38080-9(2012 Nov)
Qin SY,Hu D,Matsumoto K,Takeda K,Matsumoto N,Yamaguchi Y,Yamamoto K

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RPN1 cDNA ORF clone, Homo sapiens(human)

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