TNFRSF17 cDNA ORF clone, Homo sapiens(human)

Gene
Clones
gRNAs

Summary

Gene Symbol	TNFRSF17
Entrez Gene ID	608
Full Name	TNF receptor superfamily member 17
Synonyms	BCM,BCMA,CD269,TNFRSF13A
General protein information	Preferred Names TNF receptor superfamily member 17 Names tumor necrosis factor receptor superfamily member 17 B cell maturation antigen B-cell maturation factor B-cell maturation protein
Gene Type	protein-coding
Organism	Homo sapiens(human)
Genome	Chromosome: 16 Map Location: 16p13.13
Summary	The protein encoded by this gene is a member of the TNF-receptor superfamily. This receptor is preferentially expressed in mature B lymphocytes, and may be important for B cell development and autoimmune response. This receptor has been shown to specifically bind to the tumor necrosis factor (ligand) superfamily, member 13b (TNFSF13B/TALL-1/BAFF), and to lead to NF-kappaB and MAPK8/JNK activation. This receptor also binds to various TRAF family members, and thus may transduce signals for cell survival and proliferation. [provided by RefSeq, Jul 2008].
Disorder MIM:	109545

mRNA and Protein(s)

mRNA	Protein	Name
NM_001192.2	NP_001183.2	tumor necrosis factor receptor superfamily member 17
NM_001192.3	NP_001183.2	tumor necrosis factor receptor superfamily member 17

Pathways from BioSystems

Homologies

Mus musculus (house mouse)	Tnfrsf17	NP_035738.1
	TNFRSF17	XP_001106892.1
Canis lupus familiaris (dog)	TNFRSF17	XP_005621587.1
Rattus norvegicus (Norway rat)	Tnfrsf17	NP_001099231.1
Bos taurus (cattle)	TNFRSF17	XP_002698012.2
Homo sapiens (human)	TNFRSF17	NP_001183.2
Pan troglodytes (chimpanzee)	TNFRSF17	XP_523298.2

Gene Ontology
Bibliography

Related articles in PubMed

Soluble TACI and soluble BCMA as biomarkers in primary central nervous system lymphoma.
Thaler FS, Laurent SA, Huber M, Mulazzani M, Dreyling M, K?del U, K?mpfel T, Straube A, Meinl E, von Baumgarten L
Neuro-oncology19(12)1618-1627(2017 Nov)

Serum B-cell maturation antigen: a novel biomarker to predict outcomes for multiple myeloma patients.
Ghermezi M, Li M, Vardanyan S, Harutyunyan NM, Gottlieb J, Berenson A, Spektor TM, Andreu-Vieyra C, Petraki S, Sanchez E, Udd K, Wang CS, Swift RA, Chen H, Berenson JR
Haematologica102(4)785-795(2017 04)

Profile of BAFF and its receptors' expression in lupus nephritis is associated with pathological classes.
Suso JP, Posso-Osorio I, Jim?nez CA, Naranjo-Escobar J, Ospina FE, S?nchez A, Ca?as CA, Tob?n GJ
Lupus961203317739132(2017 Jan)

Selective Binding BAFF/APRIL by the In and Outside Conservative Region of BCMA.
Zheng C, Zhang X, Zhao Z, Hao X, Wei J, Sun J
Protein and peptide letters24(6)489-494(2017)

GeneRIFs: Gene References Into Functions What's a GeneRIF?

We have identified a specific serum protein, BCMA, as a novel independent marker for both monitoring and predicting outcomes for MM patients. We have shown that sBCMA is elevated in MM patients, and can be used to follow their disease status, PFS and OS.
Title: Serum B-cell maturation antigen: a novel biomarker to predict outcomes for multiple myeloma patients.

BCMA has other contributors for ligands binding except DxL motif. The affinity of BCMA for APRIL higher than for BAFF may be caused by the segment outside of the conservative DxL motif. Moreover, the exposition of new binding modes of BCMA2 interacting with APRIL may establish the foundation of designing novel drugs in the future
Title: Selective Binding BAFF/APRIL by the In and Outside Conservative Region of BCMA.

The expression levels of serum BAFF and the three receptors (TACI, BCMA and BAFF-R) in non-Hodgkin lymphoma patients were significantly higher than in healthy controls.
Title: The Correlation Between Non-Hodgkin Lymphoma and Expression Levels of B-Cell Activating Factor and Its Receptors.

New molecular mechanisms of in vivo Multiple Myeloma (MM) growth and immunosuppression critically dependent on BCMA and APRIL in the Bone marrow microenvironment, further supporting targeting this prominent pathway in MM.
Title: APRIL and BCMA promote human multiple myeloma growth and immunosuppression in the bone marrow microenvironment.

results suggest that Akt and JNK pathways are involved in the regulation of B-cell maturation antigen (BCMA)
Title: Binding of B-cell maturation antigen to B-cell activating factor induces survival of multiple myeloma cells by activating Akt and JNK signaling pathways.

The following TNFRSF17 gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the TNFRSF17 cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1⁺/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.

***CloneID	Accession No.	Definition	**Vector	*Turnaround time	Price (USD)
OHu17157	NM_001192.3 Latest version!	Homo sapiens TNF receptor superfamily member 17 (TNFRSF17), mRNA.	pcDNA3.1-C-(k)DYK or customized vector	in pcDNA3.1-C-(k)DYK	$49.50-$69.30 $99.00
View Old Accession Versions >>
OHu17157	NM_001192.2	Homo sapiens TNF receptor superfamily member 17 (TNFRSF17), mRNA.	pcDNA3.1-C-(k)DYK or customized vector	in pcDNA3.1-C-(k)DYK	$49.50-$69.30 $99.00
Hide Old Accession Versions >>

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** You may select a custom vector to replace pcDNA3.1+/C-(K)DYK after clone is added to cart.

** GenScript guarantees 100% sequence accuracy of all synthetic DNA constructs we deliver, but we do not guarantee protein expression in your experimental system. Protein expression is influenced by many factors that may vary between experiments or laboratories. In addition, please pay attention to the signal peptide, propeptide and transit peptide in target ORF, which may affect the choice of vector (N/C terminal tag vector).

***One clone ID might be correlated to multiple accession numbers, which share the same CDS sequence.

Reference Sequences (Refseq)

TNFRSF17 ( NM_001192.2 ) cDNA ORF clone, Homo sapiens(human) -> NP_001183.2 Homo sapiens TNF receptor superfamily member 17 (TNFRSF17), mRNA.

Price & Availability↑

CloneID	OHu17157
Clone ID Related Accession (Same CDS sequence)	NM_001192.2 , NM_001192.3
Accession Version	NM_001192.2	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 555bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2017-10-23
Organism	Homo sapiens(human)
Product	tumor necrosis factor receptor superfamily member 17
Comment	Comment: REVIEWED REFSEQ: This record has been curated by NCBI staff. The reference sequence was derived from Z29575.1. On Sep 20, 2002 this sequence version replaced NM_001192.1. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: Z29575.1, SRR1163657.456418.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA1965299, SAMEA1966682 [ECO:0000348] ##Evidence-Data-END## COMPLETENESS: complete on the 3' end.

ATGTTGCAGA TGGCTGGGCA GTGCTCCCAA AATGAATATT TTGACAGTTT GTTGCATGCT 
TGCATACCTT GTCAACTTCG ATGTTCTTCT AATACTCCTC CTCTAACATG TCAGCGTTAT 
TGTAATGCAA GTGTGACCAA TTCAGTGAAA GGAACGAATG CGATTCTCTG GACCTGTTTG 
GGACTGAGCT TAATAATTTC TTTGGCAGTT TTCGTGCTAA TGTTTTTGCT AAGGAAGATA 
AACTCTGAAC CATTAAAGGA CGAGTTTAAA AACACAGGAT CAGGTCTCCT GGGCATGGCT 
AACATTGACC TGGAAAAGAG CAGGACTGGT GATGAAATTA TTCTTCCGAG AGGCCTCGAG 
TACACGGTGG AAGAATGCAC CTGTGAAGAC TGCATCAAGA GCAAACCGAA GGTCGACTCT 
GACCATTGCT TTCCACTCCC AGCTATGGAG GAAGGCGCAA CCATTCTTGT CACCACGAAA 
ACGAATGACT ATTGCAAGAG CCTGCCAGCT GCTTTGAGTG CTACGGAGAT AGAGAAATCA 
ATTTCTGCTA GGTAA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_001183.2
CDS	219..773
Translation	MLQMAGQCSQNEYFDSLLHACIPCQLRCSSNTPPLTCQRYCNASVTNSVKGTNAILWTCLGLSLIISLAVFVLMFLLRKINSEPLKDEFKNTGSGLLGMANIDLEKSRTGDEIILPRGLEYTVEECTCEDCIKSKPKVDSDHCFPLPAMEEGATILVTTKTNDYCKSLPAALSATEIEKSISAR

Target ORF information:

RefSeq Version	NM_001192.2
Organism	Homo sapiens(human)
Definition	Homo sapiens TNF receptor superfamily member 17 (TNFRSF17), mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_001192.2

ORF Insert Sequence:

ATGTTGCAGA TGGCTGGGCA GTGCTCCCAA AATGAATATT TTGACAGTTT GTTGCATGCT 
TGCATACCTT GTCAACTTCG ATGTTCTTCT AATACTCCTC CTCTAACATG TCAGCGTTAT 
TGTAATGCAA GTGTGACCAA TTCAGTGAAA GGAACGAATG CGATTCTCTG GACCTGTTTG 
GGACTGAGCT TAATAATTTC TTTGGCAGTT TTCGTGCTAA TGTTTTTGCT AAGGAAGATA 
AACTCTGAAC CATTAAAGGA CGAGTTTAAA AACACAGGAT CAGGTCTCCT GGGCATGGCT 
AACATTGACC TGGAAAAGAG CAGGACTGGT GATGAAATTA TTCTTCCGAG AGGCCTCGAG 
TACACGGTGG AAGAATGCAC CTGTGAAGAC TGCATCAAGA GCAAACCGAA GGTCGACTCT 
GACCATTGCT TTCCACTCCC AGCTATGGAG GAAGGCGCAA CCATTCTTGT CACCACGAAA 
ACGAATGACT ATTGCAAGAG CCTGCCAGCT GCTTTGAGTG CTACGGAGAT AGAGAAATCA 
ATTTCTGCTA GGTAA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

TNFRSF17 ( NM_001192.3 ) cDNA ORF clone, Homo sapiens(human) -> NP_001183.2 Homo sapiens TNF receptor superfamily member 17 (TNFRSF17), mRNA.

Price & Availability↑

CloneID	OHu17157
Clone ID Related Accession (Same CDS sequence)	NM_001192.2 , NM_001192.3
Accession Version	NM_001192.3 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 555bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-05-20
Organism	Homo sapiens(human)
Product	tumor necrosis factor receptor superfamily member 17
Comment	Comment: REVIEWED REFSEQ: This record has been curated by NCBI staff. The reference sequence was derived from AC007216.2. On Nov 26, 2018 this sequence version replaced NM_001192.2. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: SRR1163658.304475.1, BC058291.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA1965299, SAMEA1966682 [ECO:0000348] ##Evidence-Data-END## ##RefSeq-Attributes-START## MANE Ensembl match :: ENST00000053243.6/ ENSP00000053243.1 RefSeq Select criteria :: based on single protein-coding transcript ##RefSeq-Attributes-END## COMPLETENESS: full length.

ATGTTGCAGA TGGCTGGGCA GTGCTCCCAA AATGAATATT TTGACAGTTT GTTGCATGCT 
TGCATACCTT GTCAACTTCG ATGTTCTTCT AATACTCCTC CTCTAACATG TCAGCGTTAT 
TGTAATGCAA GTGTGACCAA TTCAGTGAAA GGAACGAATG CGATTCTCTG GACCTGTTTG 
GGACTGAGCT TAATAATTTC TTTGGCAGTT TTCGTGCTAA TGTTTTTGCT AAGGAAGATA 
AACTCTGAAC CATTAAAGGA CGAGTTTAAA AACACAGGAT CAGGTCTCCT GGGCATGGCT 
AACATTGACC TGGAAAAGAG CAGGACTGGT GATGAAATTA TTCTTCCGAG AGGCCTCGAG 
TACACGGTGG AAGAATGCAC CTGTGAAGAC TGCATCAAGA GCAAACCGAA GGTCGACTCT 
GACCATTGCT TTCCACTCCC AGCTATGGAG GAAGGCGCAA CCATTCTTGT CACCACGAAA 
ACGAATGACT ATTGCAAGAG CCTGCCAGCT GCTTTGAGTG CTACGGAGAT AGAGAAATCA 
ATTTCTGCTA GGTAA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_001183.2
CDS	116..670
Translation	MLQMAGQCSQNEYFDSLLHACIPCQLRCSSNTPPLTCQRYCNASVTNSVKGTNAILWTCLGLSLIISLAVFVLMFLLRKINSEPLKDEFKNTGSGLLGMANIDLEKSRTGDEIILPRGLEYTVEECTCEDCIKSKPKVDSDHCFPLPAMEEGATILVTTKTNDYCKSLPAALSATEIEKSISAR

Target ORF information:

RefSeq Version	NM_001192.3
Organism	Homo sapiens(human)
Definition	Homo sapiens TNF receptor superfamily member 17 (TNFRSF17), mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_001192.3

ORF Insert Sequence:

ATGTTGCAGA TGGCTGGGCA GTGCTCCCAA AATGAATATT TTGACAGTTT GTTGCATGCT 
TGCATACCTT GTCAACTTCG ATGTTCTTCT AATACTCCTC CTCTAACATG TCAGCGTTAT 
TGTAATGCAA GTGTGACCAA TTCAGTGAAA GGAACGAATG CGATTCTCTG GACCTGTTTG 
GGACTGAGCT TAATAATTTC TTTGGCAGTT TTCGTGCTAA TGTTTTTGCT AAGGAAGATA 
AACTCTGAAC CATTAAAGGA CGAGTTTAAA AACACAGGAT CAGGTCTCCT GGGCATGGCT 
AACATTGACC TGGAAAAGAG CAGGACTGGT GATGAAATTA TTCTTCCGAG AGGCCTCGAG 
TACACGGTGG AAGAATGCAC CTGTGAAGAC TGCATCAAGA GCAAACCGAA GGTCGACTCT 
GACCATTGCT TTCCACTCCC AGCTATGGAG GAAGGCGCAA CCATTCTTGT CACCACGAAA 
ACGAATGACT ATTGCAAGAG CCTGCCAGCT GCTTTGAGTG CTACGGAGAT AGAGAAATCA 
ATTTCTGCTA GGTAA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

PubMed

Soluble TACI and soluble BCMA as biomarkers in primary central nervous system lymphoma.
Neuro-oncology19(12)1618-1627(2017 Nov)
Thaler FS,Laurent SA,Huber M,Mulazzani M,Dreyling M,K?del U,K?mpfel T,Straube A,Meinl E,von Baumgarten L

Serum B-cell maturation antigen: a novel biomarker to predict outcomes for multiple myeloma patients.
Haematologica102(4)785-795(2017 04)
Ghermezi M,Li M,Vardanyan S,Harutyunyan NM,Gottlieb J,Berenson A,Spektor TM,Andreu-Vieyra C,Petraki S,Sanchez E,Udd K,Wang CS,Swift RA,Chen H,Berenson JR

Profile of BAFF and its receptors' expression in lupus nephritis is associated with pathological classes.
Lupus961203317739132(2017 Jan)
Suso JP,Posso-Osorio I,Jim?nez CA,Naranjo-Escobar J,Ospina FE,S?nchez A,Ca?as CA,Tob?n GJ

Selective Binding BAFF/APRIL by the In and Outside Conservative Region of BCMA.
Protein and peptide letters24(6)489-494(2017)
Zheng C,Zhang X,Zhao Z,Hao X,Wei J,Sun J

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TNFRSF17 cDNA ORF clone, Homo sapiens(human)

Gene

Clones

gRNAs

Related articles in PubMed

Target ORF information:

Target ORF information:

ORF Insert Sequence:

Target ORF information:

Target ORF information:

ORF Insert Sequence:

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