ALX4 cDNA ORF clone, Homo sapiens(human)

Gene
Clones
gRNAs

Summary

Gene Symbol	ALX4
Entrez Gene ID	60529
Full Name	ALX homeobox 4
Synonyms	CRS5,FND2
General protein information	Preferred Names ALX homeobox 4 Names homeobox protein aristaless-like 4 aristaless-like homeobox 4 homeodomain transcription factor ALX4
Gene Type	protein-coding
Organism	Homo sapiens(human)
Genome	Chromosome: 11 Map Location: 11p11.2
Summary	This gene encodes a paired-like homeodomain transcription factor expressed in the mesenchyme of developing bones, limbs, hair, teeth, and mammary tissue. Mutations in this gene cause parietal foramina 2 (PFM2); an autosomal dominant disease characterized by deficient ossification of the parietal bones. Mutations in this gene also cause a form of frontonasal dysplasia with alopecia and hypogonadism; suggesting a role for this gene in craniofacial development, mesenchymal-epithelial communication, and hair follicle development. Deletion of a segment of chromosome 11 containing this gene, del(11)(p11p12), causes Potocki-Shaffer syndrome (PSS); a syndrome characterized by craniofacial anomalies, cognitive disability, multiple exostoses, and genital abnormalities in males. In mouse, this gene has been shown to use dual translation initiation sites located 16 codons apart. [provided by RefSeq, Oct 2009].
Disorder MIM:	605420
Disorder Html:	Parietal foramina 2, 609597 (3); Frontonasal dysplasia 2, 613451 (3); {Craniosynostosis 5, susceptibility to}, 615529 (3)

mRNA and Protein(s)

mRNA	Protein	Name
NM_021926.4	NP_068745.2	homeobox protein aristaless-like 4
NM_021926.3	NP_068745.2	homeobox protein aristaless-like 4

Pathways from BioSystems

Homologies

Mus musculus (house mouse)	Alx4	NP_031468.1
	ALX4	XP_001113643.1
Canis lupus familiaris (dog)	ALX4	XP_850737.1
Homo sapiens (human)	ALX4	NP_068745.2
Rattus norvegicus (Norway rat)	Alx4	NP_001100023.1
Gallus gallus (chicken)	ALX4	NP_989493.1
Danio rerio (zebrafish)	alx4a	XP_001340966.1
Xenopus tropicalis (tropical clawed frog)	alx4	XP_002937332.2
Bos taurus (cattle)	ALX4	NP_001025475.1
Danio rerio (zebrafish)	alx4b	NP_001082826.1
Pan troglodytes (chimpanzee)	ALX4	XP_521895.3

Gene Ontology
Bibliography

Related articles in PubMed

ALX4, an epigenetically down regulated tumor suppressor, inhibits breast cancer progression by interfering Wnt/?-catenin pathway.
Yang J, Han F, Liu W, Chen H, Hao X, Jiang X, Yin L, Huang Y, Cao J, Zhang H, Liu J
Journal of experimental & clinical cancer research : CR36(1)170(2017 Nov)

Overexpression of Aristaless-Like Homeobox-4 Inhibits Proliferation, Invasion, and EMT in Hepatocellular Carcinoma Cells.
Shi Y, Sun X, He X
Oncology research25(1)11-18(2017 Jan)

[Mother and son with enlarged parietal foramina, persistent fetal vein, and ALX4 mutation].
Morita M, Nanba E, Adachi K, Ohno K
No to hattatsu. Brain and development48(3)205-8(2016 May)

HOXB13 and ALX4 induce SLUG expression for the promotion of EMT and cell invasion in ovarian cancer cells.
Yuan H, Kajiyama H, Ito S, Chen D, Shibata K, Hamaguchi M, Kikkawa F, Senga T
Oncotarget6(15)13359-70(2015 May)

Solution NMR structures of homeodomains from human proteins ALX4, ZHX1, and CASP8AP2 contribute to the structural coverage of the Human Cancer Protein Interaction Network.
Xu X, Pulavarti SV, Eletsky A, Huang YJ, Acton TB, Xiao R, Everett JK, Montelione GT, Szyperski T
Journal of structural and functional genomics15(4)201-7(2014 Dec)

GeneRIFs: Gene References Into Functions What's a GeneRIF?

overexpression of ALX4 inhibited the proliferation, invasion, and epithelial-mesenchymal transition (EMT) in HCC cells. ALX4 had an inhibitory effect on the sonic hedgehog (Shh) signaling pathway.
Title: Overexpression of Aristaless-Like Homeobox-4 Inhibits Proliferation, Invasion, and EMT in Hepatocellular Carcinoma Cells.

mother of Case 2 also had a mutation in the ALX4 gene, but no enlarged parietal foramina
Title: [Mother and son with enlarged parietal foramina, persistent fetal vein, and ALX4 mutation].

Our results show that HOXB13/SLUG and ALX4/SLUG axes are novel pathways that promote EMT and invasion of ovarian cancer cells.
Title: HOXB13 and ALX4 induce SLUG expression for the promotion of EMT and cell invasion in ovarian cancer cells.

High-quality solution NMR structures of three homeodomains from human proteins ALX4, ZHX1 and CASP8AP2 were solved.
Title: Solution NMR structures of homeodomains from human proteins ALX4, ZHX1, and CASP8AP2 contribute to the structural coverage of the Human Cancer Protein Interaction Network.

We suggest that all ALX4 heterozygote carriers be examined in detail for possible changes in nasal configuration, to establish a detailed genotype-phenotype correlation, leading the way to more comprehensive genetic counseling.
Title: Mild nasal clefting may be predictive for ALX4 heterozygotes.

The following ALX4 gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the ALX4 cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1⁺/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.

***CloneID	Accession No.	Definition	**Vector	*Turnaround time	Price (USD)
OHu22706	NM_021926.4 Latest version!	Homo sapiens ALX homeobox 4 (ALX4), mRNA.	pcDNA3.1-C-(k)DYK or customized vector	in pcDNA3.1-C-(k)DYK	$159.50-$223.30 $319.00
View Old Accession Versions >>
OHu22706	NM_021926.3	Homo sapiens ALX homeobox 4 (ALX4), mRNA.	pcDNA3.1-C-(k)DYK or customized vector	in pcDNA3.1-C-(k)DYK	$159.50-$223.30 $319.00
Hide Old Accession Versions >>

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** GenScript guarantees 100% sequence accuracy of all synthetic DNA constructs we deliver, but we do not guarantee protein expression in your experimental system. Protein expression is influenced by many factors that may vary between experiments or laboratories. In addition, please pay attention to the signal peptide, propeptide and transit peptide in target ORF, which may affect the choice of vector (N/C terminal tag vector).

***One clone ID might be correlated to multiple accession numbers, which share the same CDS sequence.

Reference Sequences (Refseq)

ALX4 ( NM_021926.4 ) cDNA ORF clone, Homo sapiens(human) -> NP_068745.2 Homo sapiens ALX homeobox 4 (ALX4), mRNA.

Price & Availability↑

CloneID	OHu22706
Clone ID Related Accession (Same CDS sequence)	NM_021926.4 , NM_021926.3
Accession Version	NM_021926.4 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 1236bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-12-29
Organism	Homo sapiens(human)
Product	homeobox protein aristaless-like 4
Comment	Comment: REVIEWED REFSEQ: This record has been curated by NCBI staff. The reference sequence was derived from AC103854.2 and AJ404888.1. This sequence is a reference standard in the RefSeqGene project. On Jul 27, 2018 this sequence version replaced NM_021926.3. Sequence Note: The RefSeq transcript and protein were derived from transcript and genomic sequence to make the sequence consistent with the reference genome assembly. The genomic coordinates used for the transcript record were based on alignments. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: AB058691.1, AJ404888.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA1968968, SAMEA2142680 [ECO:0000348] ##Evidence-Data-END## ##RefSeq-Attributes-START## MANE Ensembl match :: ENST00000652299.1/ ENSP00000498217.1 RefSeq Select criteria :: based on single protein-coding transcript ##RefSeq-Attributes-END##

ATGAATGCTG AGACTTGCGT CTCTTACTGC GAGTCGCCGG CCGCTGCCAT GGACGCCTAC 
TACAGCCCGG TGTCGCAGAG TCGGGAGGGC TCGTCGCCTT TTAGGGCATT TCCCGGAGGC 
GACAAGTTCG GCACAACTTT CCTGTCGGCC GCCGCCAAAG CACAGGGATT CGGGGACGCC 
AAGAGCCGGG CCCGTTACGG CGCTGGGCAG CAGGACCTGG CGACACCCCT GGAGAGTGGA 
GCTGGGGCGC GGGGCTCCTT TAACAAGTTC CAGCCCCAGC CGTCGACCCC GCAGCCCCAG 
CCGCCGCCGC AGCCGCAGCC GCAGCAGCAG CAGCCGCAGC CCCAGCCGCC CGCGCAACCG 
CATCTTTACT TGCAGCGAGG CGCCTGCAAG ACGCCCCCGG ACGGCAGCCT CAAACTCCAG 
GAAGGCAGCA GCGGCCACAG CGCGGCCTTG CAGGTTCCCT GCTACGCTAA AGAGAGCTCC 
CTGGGTGAGC CAGAGTTACC CCCTGACTCT GACACTGTGG GGATGGACAG CAGCTACCTG 
AGTGTCAAGG AGGCTGGGGT GAAGGGGCCC CAGGACCGGG CCAGCTCAGA CCTCCCCAGC 
CCATTGGAGA AGGCCGACTC AGAGAGCAAC AAGGGCAAGA AGCGGCGGAA CCGGACCACC 
TTCACCAGCT ACCAGCTGGA GGAGCTGGAG AAGGTCTTCC AGAAGACCCA CTACCCAGAC 
GTGTATGCGC GGGAACAGCT GGCCATGAGG ACAGACCTCA CTGAGGCCCG CGTGCAGGTC 
TGGTTCCAGA ACCGAAGGGC CAAGTGGAGG AAGCGGGAGC GTTTTGGGCA GATGCAGCAG 
GTTCGAACCC ACTTCTCCAC TGCATATGAG CTGCCCCTCC TCACCCGAGC TGAGAACTAC 
GCCCAGATTC AGAACCCGTC CTGGCTCGGC AACAACGGGG CTGCCTCACC AGTGCCAGCC 
TGCGTGGTCC CCTGCGACCC GGTGCCTGCC TGCATGTCCC CTCATGCCCA CCCCCCTGGC 
TCTGGGGCCA GCAGCGTCAC CGACTTCCTG AGTGTGTCTG GGGCTGGCAG TCACGTGGGC 
CAGACGCACA TGGGCAGCCT GTTTGGAGCA GCCAGCCTCA GCCCAGGCCT CAATGGCTAC 
GAGCTCAACG GCGAGCCGGA CCGCAAGACC TCGAGCATCG CGGCCCTCCG CATGAAGGCC 
AAGGAGCACA GTGCGGCCAT TTCCTGGGCC ACATGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_068745.2
CDS	78..1313
Translation	MNAETCVSYCESPAAAMDAYYSPVSQSREGSSPFRAFPGGDKFGTTFLSAAAKAQGFGDAKSRARYGAGQQDLATPLESGAGARGSFNKFQPQPSTPQPQPPPQPQPQQQQPQPQPPAQPHLYLQRGACKTPPDGSLKLQEGSSGHSAALQVPCYAKESSLGEPELPPDSDTVGMDSSYLSVKEAGVKGPQDRASSDLPSPLEKADSESNKGKKRRNRTTFTSYQLEELEKVFQKTHYPDVYAREQLAMRTDLTEARVQVWFQNRRAKWRKRERFGQMQQVRTHFSTAYELPLLTRAENYAQIQNPSWLGNNGAASPVPACVVPCDPVPACMSPHAHPPGSGASSVTDFLSVSGAGSHVGQTHMGSLFGAASLSPGLNGYELNGEPDRKTSSIAALRMKAKEHSAAISWAT

Target ORF information:

RefSeq Version	NM_021926.4
Organism	Homo sapiens(human)
Definition	Homo sapiens ALX homeobox 4 (ALX4), mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_021926.4

ORF Insert Sequence:

ATGAATGCTG AGACTTGCGT CTCTTACTGC GAGTCGCCGG CCGCTGCCAT GGACGCCTAC 
TACAGCCCGG TGTCGCAGAG TCGGGAGGGC TCGTCGCCTT TTAGGGCATT TCCCGGAGGC 
GACAAGTTCG GCACAACTTT CCTGTCGGCC GCCGCCAAAG CACAGGGATT CGGGGACGCC 
AAGAGCCGGG CCCGTTACGG CGCTGGGCAG CAGGACCTGG CGACACCCCT GGAGAGTGGA 
GCTGGGGCGC GGGGCTCCTT TAACAAGTTC CAGCCCCAGC CGTCGACCCC GCAGCCCCAG 
CCGCCGCCGC AGCCGCAGCC GCAGCAGCAG CAGCCGCAGC CCCAGCCGCC CGCGCAACCG 
CATCTTTACT TGCAGCGAGG CGCCTGCAAG ACGCCCCCGG ACGGCAGCCT CAAACTCCAG 
GAAGGCAGCA GCGGCCACAG CGCGGCCTTG CAGGTTCCCT GCTACGCTAA AGAGAGCTCC 
CTGGGTGAGC CAGAGTTACC CCCTGACTCT GACACTGTGG GGATGGACAG CAGCTACCTG 
AGTGTCAAGG AGGCTGGGGT GAAGGGGCCC CAGGACCGGG CCAGCTCAGA CCTCCCCAGC 
CCATTGGAGA AGGCCGACTC AGAGAGCAAC AAGGGCAAGA AGCGGCGGAA CCGGACCACC 
TTCACCAGCT ACCAGCTGGA GGAGCTGGAG AAGGTCTTCC AGAAGACCCA CTACCCAGAC 
GTGTATGCGC GGGAACAGCT GGCCATGAGG ACAGACCTCA CTGAGGCCCG CGTGCAGGTC 
TGGTTCCAGA ACCGAAGGGC CAAGTGGAGG AAGCGGGAGC GTTTTGGGCA GATGCAGCAG 
GTTCGAACCC ACTTCTCCAC TGCATATGAG CTGCCCCTCC TCACCCGAGC TGAGAACTAC 
GCCCAGATTC AGAACCCGTC CTGGCTCGGC AACAACGGGG CTGCCTCACC AGTGCCAGCC 
TGCGTGGTCC CCTGCGACCC GGTGCCTGCC TGCATGTCCC CTCATGCCCA CCCCCCTGGC 
TCTGGGGCCA GCAGCGTCAC CGACTTCCTG AGTGTGTCTG GGGCTGGCAG TCACGTGGGC 
CAGACGCACA TGGGCAGCCT GTTTGGAGCA GCCAGCCTCA GCCCAGGCCT CAATGGCTAC 
GAGCTCAACG GCGAGCCGGA CCGCAAGACC TCGAGCATCG CGGCCCTCCG CATGAAGGCC 
AAGGAGCACA GTGCGGCCAT TTCCTGGGCC ACATGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

ALX4 ( NM_021926.3 ) cDNA ORF clone, Homo sapiens(human) -> NP_068745.2 Homo sapiens ALX homeobox 4 (ALX4), mRNA.

Price & Availability↑

CloneID	OHu22706
Clone ID Related Accession (Same CDS sequence)	NM_021926.4 , NM_021926.3
Accession Version	NM_021926.3	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 1236bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2017-10-01
Organism	Homo sapiens(human)
Product	homeobox protein aristaless-like 4
Comment	Comment: REVIEWED REFSEQ: This record has been curated by NCBI staff. The reference sequence was derived from AF294629.1, AB058691.1 and AC103854.2. This sequence is a reference standard in the RefSeqGene project. On Oct 10, 2009 this sequence version replaced NM_021926.2. Sequence Note: The RefSeq transcript and protein were derived from transcript and genomic sequence to make the sequence consistent with the reference genome assembly. The genomic coordinates used for the transcript record were based on alignments. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: AF294629.1, AB058691.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA1968968, SAMEA2142680 [ECO:0000348] ##Evidence-Data-END##

ATGAATGCTG AGACTTGCGT CTCTTACTGC GAGTCGCCGG CCGCTGCCAT GGACGCCTAC 
TACAGCCCGG TGTCGCAGAG TCGGGAGGGC TCGTCGCCTT TTAGGGCATT TCCCGGAGGC 
GACAAGTTCG GCACAACTTT CCTGTCGGCC GCCGCCAAAG CACAGGGATT CGGGGACGCC 
AAGAGCCGGG CCCGTTACGG CGCTGGGCAG CAGGACCTGG CGACACCCCT GGAGAGTGGA 
GCTGGGGCGC GGGGCTCCTT TAACAAGTTC CAGCCCCAGC CGTCGACCCC GCAGCCCCAG 
CCGCCGCCGC AGCCGCAGCC GCAGCAGCAG CAGCCGCAGC CCCAGCCGCC CGCGCAACCG 
CATCTTTACT TGCAGCGAGG CGCCTGCAAG ACGCCCCCGG ACGGCAGCCT CAAACTCCAG 
GAAGGCAGCA GCGGCCACAG CGCGGCCTTG CAGGTTCCCT GCTACGCTAA AGAGAGCTCC 
CTGGGTGAGC CAGAGTTACC CCCTGACTCT GACACTGTGG GGATGGACAG CAGCTACCTG 
AGTGTCAAGG AGGCTGGGGT GAAGGGGCCC CAGGACCGGG CCAGCTCAGA CCTCCCCAGC 
CCATTGGAGA AGGCCGACTC AGAGAGCAAC AAGGGCAAGA AGCGGCGGAA CCGGACCACC 
TTCACCAGCT ACCAGCTGGA GGAGCTGGAG AAGGTCTTCC AGAAGACCCA CTACCCAGAC 
GTGTATGCGC GGGAACAGCT GGCCATGAGG ACAGACCTCA CTGAGGCCCG CGTGCAGGTC 
TGGTTCCAGA ACCGAAGGGC CAAGTGGAGG AAGCGGGAGC GTTTTGGGCA GATGCAGCAG 
GTTCGAACCC ACTTCTCCAC TGCATATGAG CTGCCCCTCC TCACCCGAGC TGAGAACTAC 
GCCCAGATTC AGAACCCGTC CTGGCTCGGC AACAACGGGG CTGCCTCACC AGTGCCAGCC 
TGCGTGGTCC CCTGCGACCC GGTGCCTGCC TGCATGTCCC CTCATGCCCA CCCCCCTGGC 
TCTGGGGCCA GCAGCGTCAC CGACTTCCTG AGTGTGTCTG GGGCTGGCAG TCACGTGGGC 
CAGACGCACA TGGGCAGCCT GTTTGGAGCA GCCAGCCTCA GCCCAGGCCT CAATGGCTAC 
GAGCTCAACG GCGAGCCGGA CCGCAAGACC TCGAGCATCG CGGCCCTCCG CATGAAGGCC 
AAGGAGCACA GTGCGGCCAT TTCCTGGGCC ACATGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_068745.2
CDS	105..1340
Translation	MNAETCVSYCESPAAAMDAYYSPVSQSREGSSPFRAFPGGDKFGTTFLSAAAKAQGFGDAKSRARYGAGQQDLATPLESGAGARGSFNKFQPQPSTPQPQPPPQPQPQQQQPQPQPPAQPHLYLQRGACKTPPDGSLKLQEGSSGHSAALQVPCYAKESSLGEPELPPDSDTVGMDSSYLSVKEAGVKGPQDRASSDLPSPLEKADSESNKGKKRRNRTTFTSYQLEELEKVFQKTHYPDVYAREQLAMRTDLTEARVQVWFQNRRAKWRKRERFGQMQQVRTHFSTAYELPLLTRAENYAQIQNPSWLGNNGAASPVPACVVPCDPVPACMSPHAHPPGSGASSVTDFLSVSGAGSHVGQTHMGSLFGAASLSPGLNGYELNGEPDRKTSSIAALRMKAKEHSAAISWAT

Target ORF information:

RefSeq Version	NM_021926.3
Organism	Homo sapiens(human)
Definition	Homo sapiens ALX homeobox 4 (ALX4), mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_021926.3

ORF Insert Sequence:

ATGAATGCTG AGACTTGCGT CTCTTACTGC GAGTCGCCGG CCGCTGCCAT GGACGCCTAC 
TACAGCCCGG TGTCGCAGAG TCGGGAGGGC TCGTCGCCTT TTAGGGCATT TCCCGGAGGC 
GACAAGTTCG GCACAACTTT CCTGTCGGCC GCCGCCAAAG CACAGGGATT CGGGGACGCC 
AAGAGCCGGG CCCGTTACGG CGCTGGGCAG CAGGACCTGG CGACACCCCT GGAGAGTGGA 
GCTGGGGCGC GGGGCTCCTT TAACAAGTTC CAGCCCCAGC CGTCGACCCC GCAGCCCCAG 
CCGCCGCCGC AGCCGCAGCC GCAGCAGCAG CAGCCGCAGC CCCAGCCGCC CGCGCAACCG 
CATCTTTACT TGCAGCGAGG CGCCTGCAAG ACGCCCCCGG ACGGCAGCCT CAAACTCCAG 
GAAGGCAGCA GCGGCCACAG CGCGGCCTTG CAGGTTCCCT GCTACGCTAA AGAGAGCTCC 
CTGGGTGAGC CAGAGTTACC CCCTGACTCT GACACTGTGG GGATGGACAG CAGCTACCTG 
AGTGTCAAGG AGGCTGGGGT GAAGGGGCCC CAGGACCGGG CCAGCTCAGA CCTCCCCAGC 
CCATTGGAGA AGGCCGACTC AGAGAGCAAC AAGGGCAAGA AGCGGCGGAA CCGGACCACC 
TTCACCAGCT ACCAGCTGGA GGAGCTGGAG AAGGTCTTCC AGAAGACCCA CTACCCAGAC 
GTGTATGCGC GGGAACAGCT GGCCATGAGG ACAGACCTCA CTGAGGCCCG CGTGCAGGTC 
TGGTTCCAGA ACCGAAGGGC CAAGTGGAGG AAGCGGGAGC GTTTTGGGCA GATGCAGCAG 
GTTCGAACCC ACTTCTCCAC TGCATATGAG CTGCCCCTCC TCACCCGAGC TGAGAACTAC 
GCCCAGATTC AGAACCCGTC CTGGCTCGGC AACAACGGGG CTGCCTCACC AGTGCCAGCC 
TGCGTGGTCC CCTGCGACCC GGTGCCTGCC TGCATGTCCC CTCATGCCCA CCCCCCTGGC 
TCTGGGGCCA GCAGCGTCAC CGACTTCCTG AGTGTGTCTG GGGCTGGCAG TCACGTGGGC 
CAGACGCACA TGGGCAGCCT GTTTGGAGCA GCCAGCCTCA GCCCAGGCCT CAATGGCTAC 
GAGCTCAACG GCGAGCCGGA CCGCAAGACC TCGAGCATCG CGGCCCTCCG CATGAAGGCC 
AAGGAGCACA GTGCGGCCAT TTCCTGGGCC ACATGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

PubMed

ALX4, an epigenetically down regulated tumor suppressor, inhibits breast cancer progression by interfering Wnt/?-catenin pathway.
Journal of experimental & clinical cancer research : CR36(1)170(2017 Nov)
Yang J,Han F,Liu W,Chen H,Hao X,Jiang X,Yin L,Huang Y,Cao J,Zhang H,Liu J

Overexpression of Aristaless-Like Homeobox-4 Inhibits Proliferation, Invasion, and EMT in Hepatocellular Carcinoma Cells.
Oncology research25(1)11-18(2017 Jan)
Shi Y,Sun X,He X

[Mother and son with enlarged parietal foramina, persistent fetal vein, and ALX4 mutation].
No to hattatsu. Brain and development48(3)205-8(2016 May)
Morita M,Nanba E,Adachi K,Ohno K

HOXB13 and ALX4 induce SLUG expression for the promotion of EMT and cell invasion in ovarian cancer cells.
Oncotarget6(15)13359-70(2015 May)
Yuan H,Kajiyama H,Ito S,Chen D,Shibata K,Hamaguchi M,Kikkawa F,Senga T

Solution NMR structures of homeodomains from human proteins ALX4, ZHX1, and CASP8AP2 contribute to the structural coverage of the Human Cancer Protein Interaction Network.
Journal of structural and functional genomics15(4)201-7(2014 Dec)
Xu X,Pulavarti SV,Eletsky A,Huang YJ,Acton TB,Xiao R,Everett JK,Montelione GT,Szyperski T

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ALX4 cDNA ORF clone, Homo sapiens(human)

Gene

Clones

gRNAs

Related articles in PubMed

Target ORF information:

Target ORF information:

ORF Insert Sequence:

Target ORF information:

Target ORF information:

ORF Insert Sequence:

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