NYX cDNA ORF clone, Homo sapiens(human)

Gene
Clones
gRNAs

Summary

Gene Symbol	NYX
Entrez Gene ID	60506
Full Name	nyctalopin
Synonyms	CLRP,CSNB1,CSNB1A,CSNB4,NBM1
General protein information	Preferred Names nyctalopin Names nyctalopin leucine-rich repeat protein
Gene Type	protein-coding
Organism	Homo sapiens(human)
Genome	Chromosome: X Map Location: Xp11.4
Summary	The product of this gene belongs to the small leucine-rich proteoglycan (SLRP) family of proteins. Defects in this gene are the cause of congenital stationary night blindness type 1 (CSNB1), also called X-linked congenital stationary night blindness (XLCSNB). CSNB1 is a rare inherited retinal disorder characterized by impaired scotopic vision, myopia, hyperopia, nystagmus and reduced visual acuity. The role of other SLRP proteins suggests that mutations in this gene disrupt developing retinal interconnections involving the ON-bipolar cells, leading to the visual losses seen in patients with complete CSNB. [provided by RefSeq, Oct 2008].
Disorder MIM:	300278
Disorder Html:	Night blindness, congenital stationary (complete), 1A, X-linked, 310500 (3)

mRNA and Protein(s)

mRNA	Protein	Name
XM_005272632.2	XP_005272689.1	nyctalopin isoform X1
XM_017029709.1	XP_016885198.1	nyctalopin isoform X1
NM_022567.2	NP_072089.1	nyctalopin precursor

Pathways from BioSystems

Homologies

	SLRN	XP_001087613.1
Danio rerio (zebrafish)	nyx	NP_001071085.1
Canis lupus familiaris (dog)	NYX	XP_005641316.1
Bos taurus (cattle)	NYX	XP_005228361.1
Rattus norvegicus (Norway rat)	Nyx	NP_001094437.1
Homo sapiens (human)	NYX	NP_072089.1
Pan troglodytes (chimpanzee)	NYX	XP_001138632.2
Gallus gallus (chicken)	NYX	XP_004934667.1
Xenopus tropicalis (tropical clawed frog)	nyx	XP_002932845.2
Mus musculus (house mouse)	Nyx	NP_775591.1

Gene Ontology
Bibliography

Related articles in PubMed

Two Novel NYX Gene Mutations in the Chinese Families with X-linked Congenital Stationary Night Blindness.
Dai S, Ying M, Wang K, Wang L, Han R, Hao P, Li N
Scientific reports512679(2015 Aug)

NYX mutations in four families with high myopia with or without CSNB1.
Zhou L, Li T, Song X, Li Y, Li H, Dan H
Molecular vision21213-23(2015)

Genotype and phenotype of 101 dutch patients with congenital stationary night blindness.
Bijveld MM, Florijn RJ, Bergen AA, van den Born LI, Kamermans M, Prick L, Riemslag FC, van Schooneveld MJ, Kappers AM, van Genderen MM
Ophthalmology120(10)2072-81(2013 Oct)

Electroretinographic findings in a patient with congenital stationary night blindness due to a novel NYX mutation.
McAnany JJ, Alexander KR, Kumar NM, Ying H, Anastasakis A, Fishman GA
Ophthalmic genetics34(3)167-73(2013 Sep)

A novel missense mutation in the NYX gene associated with high myopia.
Yip SP, Li CC, Yiu WC, Hung WH, Lam WW, Lai MC, Ng PW, Fung WY, Chu PH, Jiang B, Chan HH, Yap MK
Ophthalmic & physiological optics : the journal of the British College of Ophthalmic Opticians (Optometrists)33(3)346-53(2013 May)

GeneRIFs: Gene References Into Functions What's a GeneRIF?

Two Novel NYX Gene Mutations in the Chinese Families with X-linked Congenital Stationary Night Blindness were described.
Title: Two Novel NYX Gene Mutations in the Chinese Families with X-linked Congenital Stationary Night Blindness.

Four potential pathogenic variations in the NYX gene were found in four families with high myopia with or without CSNB1.
Title: NYX mutations in four families with high myopia with or without CSNB1.

A mutation was identified in NYX in 20 male patients with Congenital Stationary Night Blindness 1.
Title: Genotype and phenotype of 101 dutch patients with congenital stationary night blindness.

Loss of ERG amplitude and apparent ON-pathway dysfunction at high temporal frequencies distinguish this patient with a Trp237Ter NYX mutation from those with other previously reported NYX mutations.
Title: Electroretinographic findings in a patient with congenital stationary night blindness due to a novel NYX mutation.

A missense mutation (c.529_530GC>AT or p.Ala177Met) was identified in one male subject with high myopia, but not in 200 male emmetropes.
Title: A novel missense mutation in the NYX gene associated with high myopia.

The following NYX gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the NYX cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1⁺/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.

***CloneID	Accession No.	Definition	**Vector	*Turnaround time	Price (USD)
OHu19068	NM_022567.2 Latest version!	Homo sapiens nyctalopin (NYX), mRNA.	pcDNA3.1-C-(k)DYK or customized vector	in pcDNA3.1-C-(k)DYK	$159.50-$223.30 $319.00
OHu19068	XM_005272632.2 Latest version!	Homo sapiens nyctalopin (NYX), transcript variant X1, mRNA.	pcDNA3.1-C-(k)DYK or customized vector	in pcDNA3.1-C-(k)DYK	$159.50-$223.30 $319.00
OHu19068	XM_017029709.1 Latest version!	Homo sapiens nyctalopin (NYX), transcript variant X1, mRNA.	pcDNA3.1-C-(k)DYK or customized vector	in pcDNA3.1-C-(k)DYK	$159.50-$223.30 $319.00

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** You may select a custom vector to replace pcDNA3.1+/C-(K)DYK after clone is added to cart.

** GenScript guarantees 100% sequence accuracy of all synthetic DNA constructs we deliver, but we do not guarantee protein expression in your experimental system. Protein expression is influenced by many factors that may vary between experiments or laboratories. In addition, please pay attention to the signal peptide, propeptide and transit peptide in target ORF, which may affect the choice of vector (N/C terminal tag vector).

***One clone ID might be correlated to multiple accession numbers, which share the same CDS sequence.

Reference Sequences (Refseq)

NYX ( NM_022567.2 ) cDNA ORF clone, Homo sapiens(human) -> NP_072089.1 Homo sapiens nyctalopin (NYX), mRNA.

Price & Availability↑

CloneID	OHu19068
Clone ID Related Accession (Same CDS sequence)	XM_005272632.2 , XM_017029709.1 , NM_022567.2
Accession Version	NM_022567.2 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 1446bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-12-26
Organism	Homo sapiens(human)
Product	nyctalopin precursor
Comment	Comment: REVIEWED REFSEQ: This record has been curated by NCBI staff. The reference sequence was derived from AJ278865.1. This sequence is a reference standard in the RefSeqGene project. On Sep 13, 2008 this sequence version replaced NM_022567.1. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: AJ278865.1, BC112242.1 [ECO:0000332] ##Evidence-Data-END## ##RefSeq-Attributes-START## RefSeq Select criteria :: based on conservation, expression, longest protein ##RefSeq-Attributes-END## COMPLETENESS: complete on the 3' end.

ATGAAAGGCC GAGGGATGTT GGTCCTGCTT CTGCATGCGG TGGTCCTCGG CCTGCCCAGC 
GCCTGGGCCG TGGGGGCCTG CGCCCGCGCT TGTCCCGCCG CCTGCGCCTG CAGCACCGTG 
GAGCGCGGCT GCTCGGTGCG CTGCGACCGC GCGGGCCTCC TGCGGGTGCC GGCCGAGCTC 
CCGTGCGAGG CGGTCTCCAT CGACCTGGAC CGGAACGGCC TGCGCTTCCT GGGCGAGCGA 
GCCTTCGGCA CGCTGCCGTC CTTGCGCCGC CTGTCGCTGC GCCACAACAA CCTGTCCTTC 
ATCACGCCCG GCGCCTTCAA GGGCCTGCCG CGCCTGGCTG AGCTGCGCCT GGCGCACAAC 
GGCGACCTGC GCTACCTGCA CGCGCGCACC TTCGCGGCGC TCAGCCGCCT GCGCCGCCTA 
GACCTAGCAG CCTGCCGCCT CTTCAGCGTG CCCGAGCGCC TCCTGGCCGA ACTGCCGGCC 
CTGCGCGAAC TCGCCGCCTT CGACAACCTG TTCCGCCGCG TGCCGGGCGC GCTGCGCGGC 
CTGGCCAACC TGACGCACGC GCACCTGGAG CGCGGCCGCA TCGAGGCGGT GGCCTCCAGC 
TCGCTGCAGG GCCTGCGCCG CCTGCGCTCG CTCAGCCTGC AGGCCAACCG CGTCCGTGCC 
GTGCACGCTG GCGCCTTCGG GGACTGTGGC GTCCTGGAGC ATCTGCTGCT CAACGACAAC 
CTGCTGGCCG AGCTCCCGGC CGACGCCTTC CGCGGCCTGC GGCGCCTGCG CACGCTCAAC 
CTGGGTGGCA ACGCGCTGGA CCGCGTGGCG CGCGCCTGGT TCGCTGACCT GGCCGAGCTC 
GAGCTGCTCT ACCTGGACCG CAACAGCATC GCCTTCGTGG AGGAGGGCGC CTTCCAGAAC 
CTCTCGGGTC TCCTCGCGCT GCACCTCAAC GGCAACCGCC TCACCGTGCT CGCCTGGGTC 
GCCTTCCAGC CCGGCTTCTT CCTGGGCCGC CTCTTCCTCT TCCGCAACCC GTGGTGCTGC 
GACTGCCGTC TGGAGTGGCT GAGGGACTGG ATGGAGGGCT CCGGACGTGT CACCGACGTG 
CCGTGCGCCT CCCCGGGCTC CGTGGCCGGC CTGGACCTCA GCCAGGTGAC CTTCGGGCGC 
TCCTCCGATG GCCTCTGTGT GGACCCCGAG GAGCTGAACC TCACCACGTC CAGTCCAGGC 
CCGTCCCCAG AACCAGCGGC CACCACCGTG AGCAGGTTCA GCAGCCTCCT CTCCAAGCTG 
CTGGCCCCGA GGGTCCCGGT GGAGGAGGCG GCCAACACCA CTGGGGGGCT GGCCAACGCC 
TCCCTGTCCG ACAGCCTCTC CTCCCGTGGG GTGGGAGGCG CGGGCCGGCA GCCCTGGTTT 
CTCCTCGCCT CTTGTCTCCT GCCCAGCGTG GCCCAGCACG TGGTGTTTGG CCTGCAGATG 
GACTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_072089.1
CDS	431..1876
Translation	MKGRGMLVLLLHAVVLGLPSAWAVGACARACPAACACSTVERGCSVRCDRAGLLRVPAELPCEAVSIDLDRNGLRFLGERAFGTLPSLRRLSLRHNNLSFITPGAFKGLPRLAELRLAHNGDLRYLHARTFAALSRLRRLDLAACRLFSVPERLLAELPALRELAAFDNLFRRVPGALRGLANLTHAHLERGRIEAVASSSLQGLRRLRSLSLQANRVRAVHAGAFGDCGVLEHLLLNDNLLAELPADAFRGLRRLRTLNLGGNALDRVARAWFADLAELELLYLDRNSIAFVEEGAFQNLSGLLALHLNGNRLTVLAWVAFQPGFFLGRLFLFRNPWCCDCRLEWLRDWMEGSGRVTDVPCASPGSVAGLDLSQVTFGRSSDGLCVDPEELNLTTSSPGPSPEPAATTVSRFSSLLSKLLAPRVPVEEAANTTGGLANASLSDSLSSRGVGGAGRQPWFLLASCLLPSVAQHVVFGLQMD

Target ORF information:

RefSeq Version	NM_022567.2
Organism	Homo sapiens(human)
Definition	Homo sapiens nyctalopin (NYX), mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_022567.2

ORF Insert Sequence:

ATGAAAGGCC GAGGGATGTT GGTCCTGCTT CTGCATGCGG TGGTCCTCGG CCTGCCCAGC 
GCCTGGGCCG TGGGGGCCTG CGCCCGCGCT TGTCCCGCCG CCTGCGCCTG CAGCACCGTG 
GAGCGCGGCT GCTCGGTGCG CTGCGACCGC GCGGGCCTCC TGCGGGTGCC GGCCGAGCTC 
CCGTGCGAGG CGGTCTCCAT CGACCTGGAC CGGAACGGCC TGCGCTTCCT GGGCGAGCGA 
GCCTTCGGCA CGCTGCCGTC CTTGCGCCGC CTGTCGCTGC GCCACAACAA CCTGTCCTTC 
ATCACGCCCG GCGCCTTCAA GGGCCTGCCG CGCCTGGCTG AGCTGCGCCT GGCGCACAAC 
GGCGACCTGC GCTACCTGCA CGCGCGCACC TTCGCGGCGC TCAGCCGCCT GCGCCGCCTA 
GACCTAGCAG CCTGCCGCCT CTTCAGCGTG CCCGAGCGCC TCCTGGCCGA ACTGCCGGCC 
CTGCGCGAAC TCGCCGCCTT CGACAACCTG TTCCGCCGCG TGCCGGGCGC GCTGCGCGGC 
CTGGCCAACC TGACGCACGC GCACCTGGAG CGCGGCCGCA TCGAGGCGGT GGCCTCCAGC 
TCGCTGCAGG GCCTGCGCCG CCTGCGCTCG CTCAGCCTGC AGGCCAACCG CGTCCGTGCC 
GTGCACGCTG GCGCCTTCGG GGACTGTGGC GTCCTGGAGC ATCTGCTGCT CAACGACAAC 
CTGCTGGCCG AGCTCCCGGC CGACGCCTTC CGCGGCCTGC GGCGCCTGCG CACGCTCAAC 
CTGGGTGGCA ACGCGCTGGA CCGCGTGGCG CGCGCCTGGT TCGCTGACCT GGCCGAGCTC 
GAGCTGCTCT ACCTGGACCG CAACAGCATC GCCTTCGTGG AGGAGGGCGC CTTCCAGAAC 
CTCTCGGGTC TCCTCGCGCT GCACCTCAAC GGCAACCGCC TCACCGTGCT CGCCTGGGTC 
GCCTTCCAGC CCGGCTTCTT CCTGGGCCGC CTCTTCCTCT TCCGCAACCC GTGGTGCTGC 
GACTGCCGTC TGGAGTGGCT GAGGGACTGG ATGGAGGGCT CCGGACGTGT CACCGACGTG 
CCGTGCGCCT CCCCGGGCTC CGTGGCCGGC CTGGACCTCA GCCAGGTGAC CTTCGGGCGC 
TCCTCCGATG GCCTCTGTGT GGACCCCGAG GAGCTGAACC TCACCACGTC CAGTCCAGGC 
CCGTCCCCAG AACCAGCGGC CACCACCGTG AGCAGGTTCA GCAGCCTCCT CTCCAAGCTG 
CTGGCCCCGA GGGTCCCGGT GGAGGAGGCG GCCAACACCA CTGGGGGGCT GGCCAACGCC 
TCCCTGTCCG ACAGCCTCTC CTCCCGTGGG GTGGGAGGCG CGGGCCGGCA GCCCTGGTTT 
CTCCTCGCCT CTTGTCTCCT GCCCAGCGTG GCCCAGCACG TGGTGTTTGG CCTGCAGATG 
GACTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

NYX ( XM_005272632.2 ) cDNA ORF clone, Homo sapiens(human) -> XP_005272689.1 Homo sapiens nyctalopin (NYX), transcript variant X1, mRNA.

Price & Availability↑

CloneID	OHu19068
Clone ID Related Accession (Same CDS sequence)	XM_005272632.2 , XM_017029709.1 , NM_022567.2
Accession Version	XM_005272632.2 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 1446bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2015-03-11
Organism	Homo sapiens(Human)
Product	nyctalopin isoform X1
Comment

ATGAAAGGCC GAGGGATGTT GGTCCTGCTT CTGCATGCGG TGGTCCTCGG CCTGCCCAGC 
GCCTGGGCCG TGGGGGCCTG CGCCCGCGCT TGTCCCGCCG CCTGCGCCTG CAGCACCGTG 
GAGCGCGGCT GCTCGGTGCG CTGCGACCGC GCGGGCCTCC TGCGGGTGCC GGCCGAGCTC 
CCGTGCGAGG CGGTCTCCAT CGACCTGGAC CGGAACGGCC TGCGCTTCCT GGGCGAGCGA 
GCCTTCGGCA CGCTGCCGTC CTTGCGCCGC CTGTCGCTGC GCCACAACAA CCTGTCCTTC 
ATCACGCCCG GCGCCTTCAA GGGCCTGCCG CGCCTGGCTG AGCTGCGCCT GGCGCACAAC 
GGCGACCTGC GCTACCTGCA CGCGCGCACC TTCGCGGCGC TCAGCCGCCT GCGCCGCCTA 
GACCTAGCAG CCTGCCGCCT CTTCAGCGTG CCCGAGCGCC TCCTGGCCGA ACTGCCGGCC 
CTGCGCGAAC TCGCCGCCTT CGACAACCTG TTCCGCCGCG TGCCGGGCGC GCTGCGCGGC 
CTGGCCAACC TGACGCACGC GCACCTGGAG CGCGGCCGCA TCGAGGCGGT GGCCTCCAGC 
TCGCTGCAGG GCCTGCGCCG CCTGCGCTCG CTCAGCCTGC AGGCCAACCG CGTCCGTGCC 
GTGCACGCTG GCGCCTTCGG GGACTGTGGC GTCCTGGAGC ATCTGCTGCT CAACGACAAC 
CTGCTGGCCG AGCTCCCGGC CGACGCCTTC CGCGGCCTGC GGCGCCTGCG CACGCTCAAC 
CTGGGTGGCA ACGCGCTGGA CCGCGTGGCG CGCGCCTGGT TCGCTGACCT GGCCGAGCTC 
GAGCTGCTCT ACCTGGACCG CAACAGCATC GCCTTCGTGG AGGAGGGCGC CTTCCAGAAC 
CTCTCGGGTC TCCTCGCGCT GCACCTCAAC GGCAACCGCC TCACCGTGCT CGCCTGGGTC 
GCCTTCCAGC CCGGCTTCTT CCTGGGCCGC CTCTTCCTCT TCCGCAACCC GTGGTGCTGC 
GACTGCCGTC TGGAGTGGCT GAGGGACTGG ATGGAGGGCT CCGGACGTGT CACCGACGTG 
CCGTGCGCCT CCCCGGGCTC CGTGGCCGGC CTGGACCTCA GCCAGGTGAC CTTCGGGCGC 
TCCTCCGATG GCCTCTGTGT GGACCCCGAG GAGCTGAACC TCACCACGTC CAGTCCAGGC 
CCGTCCCCAG AACCAGCGGC CACCACCGTG AGCAGGTTCA GCAGCCTCCT CTCCAAGCTG 
CTGGCCCCGA GGGTCCCGGT GGAGGAGGCG GCCAACACCA CTGGGGGGCT GGCCAACGCC 
TCCCTGTCCG ACAGCCTCTC CTCCCGTGGG GTGGGAGGCG CGGGCCGGCA GCCCTGGTTT 
CTCCTCGCCT CTTGTCTCCT GCCCAGCGTG GCCCAGCACG TGGTGTTTGG CCTGCAGATG 
GACTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq

XP_005272689.1

Translation

MKGRGMLVLLLHAVVLGLPSAWAVGACARACPAACACSTVERGCSVRCDRAGLLRVPAELPCEAVSIDLDRNGLRFLGERAFGTLPSLRRLSLRHNNLSFITPGAFKGLPRLAELRLAHNGDLRYLHARTFAALSRLRRLDLAACRLFSVPERLLAELPALRELAAFDNLFRRVPGALRGLANLTHAHLERGRIEAVASSSLQGLRRLRSLSLQANRVRAVHAGAFGDCGVLEHLLLNDNLLAELPADAFRGLRRLRTLNLGGNALDRVARAWFADLAELELLYLDRNSIAFVEEGAFQNLSGLLALHLNGNRLTVLAWVAFQPGFFLGRLFLFRNPWCCDCRLEWLRDWMEGSGRVTDVPCASPGSVAGLDLSQVTFGRSSDGLCVDPEELNLTTSSPGPSPEPAATTVSRFSSLLSKLLAPRVPVEEAANTTGGLANASLSDSLSSRGVGGAGRQPWFLLASCLLPSVAQHVVFGLQMD

Target ORF information:

RefSeq Version	XM_005272632.2
Organism	Homo sapiens(Human)
Definition	Homo sapiens nyctalopin (NYX), transcript variant X1, mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

XM_005272632.2

ORF Insert Sequence:

ATGAAAGGCC GAGGGATGTT GGTCCTGCTT CTGCATGCGG TGGTCCTCGG CCTGCCCAGC 
GCCTGGGCCG TGGGGGCCTG CGCCCGCGCT TGTCCCGCCG CCTGCGCCTG CAGCACCGTG 
GAGCGCGGCT GCTCGGTGCG CTGCGACCGC GCGGGCCTCC TGCGGGTGCC GGCCGAGCTC 
CCGTGCGAGG CGGTCTCCAT CGACCTGGAC CGGAACGGCC TGCGCTTCCT GGGCGAGCGA 
GCCTTCGGCA CGCTGCCGTC CTTGCGCCGC CTGTCGCTGC GCCACAACAA CCTGTCCTTC 
ATCACGCCCG GCGCCTTCAA GGGCCTGCCG CGCCTGGCTG AGCTGCGCCT GGCGCACAAC 
GGCGACCTGC GCTACCTGCA CGCGCGCACC TTCGCGGCGC TCAGCCGCCT GCGCCGCCTA 
GACCTAGCAG CCTGCCGCCT CTTCAGCGTG CCCGAGCGCC TCCTGGCCGA ACTGCCGGCC 
CTGCGCGAAC TCGCCGCCTT CGACAACCTG TTCCGCCGCG TGCCGGGCGC GCTGCGCGGC 
CTGGCCAACC TGACGCACGC GCACCTGGAG CGCGGCCGCA TCGAGGCGGT GGCCTCCAGC 
TCGCTGCAGG GCCTGCGCCG CCTGCGCTCG CTCAGCCTGC AGGCCAACCG CGTCCGTGCC 
GTGCACGCTG GCGCCTTCGG GGACTGTGGC GTCCTGGAGC ATCTGCTGCT CAACGACAAC 
CTGCTGGCCG AGCTCCCGGC CGACGCCTTC CGCGGCCTGC GGCGCCTGCG CACGCTCAAC 
CTGGGTGGCA ACGCGCTGGA CCGCGTGGCG CGCGCCTGGT TCGCTGACCT GGCCGAGCTC 
GAGCTGCTCT ACCTGGACCG CAACAGCATC GCCTTCGTGG AGGAGGGCGC CTTCCAGAAC 
CTCTCGGGTC TCCTCGCGCT GCACCTCAAC GGCAACCGCC TCACCGTGCT CGCCTGGGTC 
GCCTTCCAGC CCGGCTTCTT CCTGGGCCGC CTCTTCCTCT TCCGCAACCC GTGGTGCTGC 
GACTGCCGTC TGGAGTGGCT GAGGGACTGG ATGGAGGGCT CCGGACGTGT CACCGACGTG 
CCGTGCGCCT CCCCGGGCTC CGTGGCCGGC CTGGACCTCA GCCAGGTGAC CTTCGGGCGC 
TCCTCCGATG GCCTCTGTGT GGACCCCGAG GAGCTGAACC TCACCACGTC CAGTCCAGGC 
CCGTCCCCAG AACCAGCGGC CACCACCGTG AGCAGGTTCA GCAGCCTCCT CTCCAAGCTG 
CTGGCCCCGA GGGTCCCGGT GGAGGAGGCG GCCAACACCA CTGGGGGGCT GGCCAACGCC 
TCCCTGTCCG ACAGCCTCTC CTCCCGTGGG GTGGGAGGCG CGGGCCGGCA GCCCTGGTTT 
CTCCTCGCCT CTTGTCTCCT GCCCAGCGTG GCCCAGCACG TGGTGTTTGG CCTGCAGATG 
GACTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

NYX ( XM_017029709.1 ) cDNA ORF clone, Homo sapiens(human) -> XP_016885198.1 Homo sapiens nyctalopin (NYX), transcript variant X1, mRNA.

Price & Availability↑

CloneID	OHu19068
Clone ID Related Accession (Same CDS sequence)	XM_005272632.2 , XM_017029709.1 , NM_022567.2
Accession Version	XM_017029709.1 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 1446bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-12-05
Organism	Homo sapiens(human)
Product	nyctalopin isoform X1
Comment	Comment: MODEL REFSEQ: This record is predicted by automated computational analysis. This record is derived from a genomic sequence (NC_000023.11) annotated using gene prediction method: Gnomon, supported by mRNA evidence. Also see: Documentation of NCBI's Annotation Process ##Genome-Annotation-Data-START## Annotation Provider :: NCBI Annotation Status :: Updated annotation Annotation Name :: Homo sapiens Updated Annotation Release 109.20191205 Annotation Version :: 109.20191205 Annotation Pipeline :: NCBI eukaryotic genome annotation pipeline Annotation Software Version :: 8.3 Annotation Method :: Best-placed RefSeq; propagated RefSeq model Features Annotated :: Gene; mRNA; CDS; ncRNA ##Genome-Annotation-Data-END##

ATGAAAGGCC GAGGGATGTT GGTCCTGCTT CTGCATGCGG TGGTCCTCGG CCTGCCCAGC 
GCCTGGGCCG TGGGGGCCTG CGCCCGCGCT TGTCCCGCCG CCTGCGCCTG CAGCACCGTG 
GAGCGCGGCT GCTCGGTGCG CTGCGACCGC GCGGGCCTCC TGCGGGTGCC GGCCGAGCTC 
CCGTGCGAGG CGGTCTCCAT CGACCTGGAC CGGAACGGCC TGCGCTTCCT GGGCGAGCGA 
GCCTTCGGCA CGCTGCCGTC CTTGCGCCGC CTGTCGCTGC GCCACAACAA CCTGTCCTTC 
ATCACGCCCG GCGCCTTCAA GGGCCTGCCG CGCCTGGCTG AGCTGCGCCT GGCGCACAAC 
GGCGACCTGC GCTACCTGCA CGCGCGCACC TTCGCGGCGC TCAGCCGCCT GCGCCGCCTA 
GACCTAGCAG CCTGCCGCCT CTTCAGCGTG CCCGAGCGCC TCCTGGCCGA ACTGCCGGCC 
CTGCGCGAAC TCGCCGCCTT CGACAACCTG TTCCGCCGCG TGCCGGGCGC GCTGCGCGGC 
CTGGCCAACC TGACGCACGC GCACCTGGAG CGCGGCCGCA TCGAGGCGGT GGCCTCCAGC 
TCGCTGCAGG GCCTGCGCCG CCTGCGCTCG CTCAGCCTGC AGGCCAACCG CGTCCGTGCC 
GTGCACGCTG GCGCCTTCGG GGACTGTGGC GTCCTGGAGC ATCTGCTGCT CAACGACAAC 
CTGCTGGCCG AGCTCCCGGC CGACGCCTTC CGCGGCCTGC GGCGCCTGCG CACGCTCAAC 
CTGGGTGGCA ACGCGCTGGA CCGCGTGGCG CGCGCCTGGT TCGCTGACCT GGCCGAGCTC 
GAGCTGCTCT ACCTGGACCG CAACAGCATC GCCTTCGTGG AGGAGGGCGC CTTCCAGAAC 
CTCTCGGGTC TCCTCGCGCT GCACCTCAAC GGCAACCGCC TCACCGTGCT CGCCTGGGTC 
GCCTTCCAGC CCGGCTTCTT CCTGGGCCGC CTCTTCCTCT TCCGCAACCC GTGGTGCTGC 
GACTGCCGTC TGGAGTGGCT GAGGGACTGG ATGGAGGGCT CCGGACGTGT CACCGACGTG 
CCGTGCGCCT CCCCGGGCTC CGTGGCCGGC CTGGACCTCA GCCAGGTGAC CTTCGGGCGC 
TCCTCCGATG GCCTCTGTGT GGACCCCGAG GAGCTGAACC TCACCACGTC CAGTCCAGGC 
CCGTCCCCAG AACCAGCGGC CACCACCGTG AGCAGGTTCA GCAGCCTCCT CTCCAAGCTG 
CTGGCCCCGA GGGTCCCGGT GGAGGAGGCG GCCAACACCA CTGGGGGGCT GGCCAACGCC 
TCCCTGTCCG ACAGCCTCTC CTCCCGTGGG GTGGGAGGCG CGGGCCGGCA GCCCTGGTTT 
CTCCTCGCCT CTTGTCTCCT GCCCAGCGTG GCCCAGCACG TGGTGTTTGG CCTGCAGATG 
GACTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	XP_016885198.1
CDS	99..1544
Translation	MKGRGMLVLLLHAVVLGLPSAWAVGACARACPAACACSTVERGCSVRCDRAGLLRVPAELPCEAVSIDLDRNGLRFLGERAFGTLPSLRRLSLRHNNLSFITPGAFKGLPRLAELRLAHNGDLRYLHARTFAALSRLRRLDLAACRLFSVPERLLAELPALRELAAFDNLFRRVPGALRGLANLTHAHLERGRIEAVASSSLQGLRRLRSLSLQANRVRAVHAGAFGDCGVLEHLLLNDNLLAELPADAFRGLRRLRTLNLGGNALDRVARAWFADLAELELLYLDRNSIAFVEEGAFQNLSGLLALHLNGNRLTVLAWVAFQPGFFLGRLFLFRNPWCCDCRLEWLRDWMEGSGRVTDVPCASPGSVAGLDLSQVTFGRSSDGLCVDPEELNLTTSSPGPSPEPAATTVSRFSSLLSKLLAPRVPVEEAANTTGGLANASLSDSLSSRGVGGAGRQPWFLLASCLLPSVAQHVVFGLQMD

Target ORF information:

RefSeq Version	XM_017029709.1
Organism	Homo sapiens(human)
Definition	Homo sapiens nyctalopin (NYX), transcript variant X1, mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

XM_017029709.1

ORF Insert Sequence:

ATGAAAGGCC GAGGGATGTT GGTCCTGCTT CTGCATGCGG TGGTCCTCGG CCTGCCCAGC 
GCCTGGGCCG TGGGGGCCTG CGCCCGCGCT TGTCCCGCCG CCTGCGCCTG CAGCACCGTG 
GAGCGCGGCT GCTCGGTGCG CTGCGACCGC GCGGGCCTCC TGCGGGTGCC GGCCGAGCTC 
CCGTGCGAGG CGGTCTCCAT CGACCTGGAC CGGAACGGCC TGCGCTTCCT GGGCGAGCGA 
GCCTTCGGCA CGCTGCCGTC CTTGCGCCGC CTGTCGCTGC GCCACAACAA CCTGTCCTTC 
ATCACGCCCG GCGCCTTCAA GGGCCTGCCG CGCCTGGCTG AGCTGCGCCT GGCGCACAAC 
GGCGACCTGC GCTACCTGCA CGCGCGCACC TTCGCGGCGC TCAGCCGCCT GCGCCGCCTA 
GACCTAGCAG CCTGCCGCCT CTTCAGCGTG CCCGAGCGCC TCCTGGCCGA ACTGCCGGCC 
CTGCGCGAAC TCGCCGCCTT CGACAACCTG TTCCGCCGCG TGCCGGGCGC GCTGCGCGGC 
CTGGCCAACC TGACGCACGC GCACCTGGAG CGCGGCCGCA TCGAGGCGGT GGCCTCCAGC 
TCGCTGCAGG GCCTGCGCCG CCTGCGCTCG CTCAGCCTGC AGGCCAACCG CGTCCGTGCC 
GTGCACGCTG GCGCCTTCGG GGACTGTGGC GTCCTGGAGC ATCTGCTGCT CAACGACAAC 
CTGCTGGCCG AGCTCCCGGC CGACGCCTTC CGCGGCCTGC GGCGCCTGCG CACGCTCAAC 
CTGGGTGGCA ACGCGCTGGA CCGCGTGGCG CGCGCCTGGT TCGCTGACCT GGCCGAGCTC 
GAGCTGCTCT ACCTGGACCG CAACAGCATC GCCTTCGTGG AGGAGGGCGC CTTCCAGAAC 
CTCTCGGGTC TCCTCGCGCT GCACCTCAAC GGCAACCGCC TCACCGTGCT CGCCTGGGTC 
GCCTTCCAGC CCGGCTTCTT CCTGGGCCGC CTCTTCCTCT TCCGCAACCC GTGGTGCTGC 
GACTGCCGTC TGGAGTGGCT GAGGGACTGG ATGGAGGGCT CCGGACGTGT CACCGACGTG 
CCGTGCGCCT CCCCGGGCTC CGTGGCCGGC CTGGACCTCA GCCAGGTGAC CTTCGGGCGC 
TCCTCCGATG GCCTCTGTGT GGACCCCGAG GAGCTGAACC TCACCACGTC CAGTCCAGGC 
CCGTCCCCAG AACCAGCGGC CACCACCGTG AGCAGGTTCA GCAGCCTCCT CTCCAAGCTG 
CTGGCCCCGA GGGTCCCGGT GGAGGAGGCG GCCAACACCA CTGGGGGGCT GGCCAACGCC 
TCCCTGTCCG ACAGCCTCTC CTCCCGTGGG GTGGGAGGCG CGGGCCGGCA GCCCTGGTTT 
CTCCTCGCCT CTTGTCTCCT GCCCAGCGTG GCCCAGCACG TGGTGTTTGG CCTGCAGATG 
GACTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

PubMed

Two Novel NYX Gene Mutations in the Chinese Families with X-linked Congenital Stationary Night Blindness.
Scientific reports512679(2015 Aug)
Dai S,Ying M,Wang K,Wang L,Han R,Hao P,Li N

NYX mutations in four families with high myopia with or without CSNB1.
Molecular vision21213-23(2015)
Zhou L,Li T,Song X,Li Y,Li H,Dan H

Genotype and phenotype of 101 dutch patients with congenital stationary night blindness.
Ophthalmology120(10)2072-81(2013 Oct)
Bijveld MM,Florijn RJ,Bergen AA,van den Born LI,Kamermans M,Prick L,Riemslag FC,van Schooneveld MJ,Kappers AM,van Genderen MM

Electroretinographic findings in a patient with congenital stationary night blindness due to a novel NYX mutation.
Ophthalmic genetics34(3)167-73(2013 Sep)
McAnany JJ,Alexander KR,Kumar NM,Ying H,Anastasakis A,Fishman GA

A novel missense mutation in the NYX gene associated with high myopia.
Ophthalmic & physiological optics : the journal of the British College of Ophthalmic Opticians (Optometrists)33(3)346-53(2013 May)
Yip SP,Li CC,Yiu WC,Hung WH,Lam WW,Lai MC,Ng PW,Fung WY,Chu PH,Jiang B,Chan HH,Yap MK

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NYX cDNA ORF clone, Homo sapiens(human)

Gene

Clones

gRNAs

Related articles in PubMed

Target ORF information:

Target ORF information:

ORF Insert Sequence:

Target ORF information:

Target ORF information:

ORF Insert Sequence:

Target ORF information:

Target ORF information:

ORF Insert Sequence:

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