RGS10 cDNA ORF clone, Homo sapiens(human)

Gene
Clones
gRNAs

Summary

Gene Symbol	RGS10
Entrez Gene ID	6001
Full Name	regulator of G protein signaling 10
General protein information	Preferred Names regulator of G protein signaling 10 Names regulator of G-protein signaling 10 regulator of G-protein signalling 10
Gene Type	protein-coding
Organism	Homo sapiens(human)
Genome	Chromosome: 10 Map Location: 10q26.11
Summary	Regulator of G protein signaling (RGS) family members are regulatory molecules that act as GTPase activating proteins (GAPs) for G alpha subunits of heterotrimeric G proteins. RGS proteins are able to deactivate G protein subunits of the Gi alpha, Go alpha and Gq alpha subtypes. They drive G proteins into their inactive GDP-bound forms. Regulator of G protein signaling 10 belongs to this family. All RGS proteins share a conserved 120-amino acid sequence termed the RGS domain. This protein associates specifically with the activated forms of the two related G-protein subunits, G-alphai3 and G-alphaz but fails to interact with the structurally and functionally distinct G-alpha subunits. Regulator of G protein signaling 10 protein is localized in the nucleus. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008].
Disorder MIM:	602856

mRNA and Protein(s)

mRNA	Protein	Name
XM_017016492.1	XP_016871981.1	regulator of G-protein signaling 10 isoform X1
XM_017016493.1	XP_016871982.1	regulator of G-protein signaling 10 isoform X2
NM_001005339.1	NP_001005339.1	regulator of G-protein signaling 10 isoform a
NM_002925.3	NP_002916.1	regulator of G-protein signaling 10 isoform b
NM_001005339.2	NP_001005339.1	regulator of G-protein signaling 10 isoform a

Pathways from BioSystems

Homologies

Canis lupus familiaris (dog)	RGS10	XP_535032.3
Pan troglodytes (chimpanzee)	RGS10	XP_003951820.1
Bos taurus (cattle)	RGS10	NP_001040005.1
Gallus gallus (chicken)	RGS10	XP_421790.3
Homo sapiens (human)	RGS10	NP_001005339.1
	RGS10	XP_001097657.1
Mus musculus (house mouse)	Rgs10	NP_080694.1
Rattus norvegicus (Norway rat)	Rgs10	NP_062210.1
Xenopus tropicalis (tropical clawed frog)	rgs10	NP_001011425.1

Gene Ontology
Bibliography

Related articles in PubMed

Suppression of the GTPase-activating protein RGS10 increases Rheb-GTP and mTOR signaling in ovarian cancer cells.
Altman MK, Alshamrani AA, Jia W, Nguyen HT, Fambrough JM, Tran SK, Patel MB, Hoseinzadeh P, Beedle AM, Murph MM
Cancer letters369(1)175-83(2015 Dec)

Cellular deficiency in the RGS10 protein facilitates chemoresistant ovarian cancer.
Hooks SB, Murph MM
Future medicinal chemistry7(12)1483-9(2015 Aug)

Inhibition of HDAC1 and DNMT1 modulate RGS10 expression and decrease ovarian cancer chemoresistance.
Cacan E, Ali MW, Boyd NH, Hooks SB, Greer SF
PloS one9(1)e87455(2014)

Brain RGS4 and RGS10 protein expression in schizophrenia and depression. Effect of drug treatment.
Rivero G, Gabilondo AM, Garc?a-Sevilla JA, Callado LF, La Harpe R, Morentin B, Meana JJ
Psychopharmacology226(1)177-88(2013 Mar)

GeneRIFs: Gene References Into Functions What's a GeneRIF?

RGS10 could serve in a novel, and previously unknown, role by accelerating the hydrolysis of GTP from Rheb in ovarian cancer cells.
Title: Suppression of the GTPase-activating protein RGS10 increases Rheb-GTP and mTOR signaling in ovarian cancer cells.

RGS10 plays a role in chemoresistance in ovarian cancer. Loss of RGS10 enhances survival among these cells.
Title: Cellular deficiency in the RGS10 protein facilitates chemoresistant ovarian cancer.

Inhibition of HDAC1 and DNMT1 modulate RGS10 expression and decrease ovarian cancer chemoresistance.
Title: Inhibition of HDAC1 and DNMT1 modulate RGS10 expression and decrease ovarian cancer chemoresistance.

The results suggest unaltered membrane RGS4 and cytosolic RGS10 proteins levels in schizophrenia and major depression.
Title: Brain RGS4 and RGS10 protein expression in schizophrenia and depression. Effect of drug treatment.

Data show that that SPL/RGS/SHP1 complexes are present in resting platelets where constitutive phosphorylation of SPL(Y398) creates an atypical binding site for SHP-1.
Title: A newly identified complex of spinophilin and the tyrosine phosphatase, SHP-1, modulates platelet activation by regulating G protein-dependent signaling.

The following RGS10 gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the RGS10 cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1⁺/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.

***CloneID	Accession No.	Definition	**Vector	*Turnaround time	Price (USD)
OHu03666	NM_001005339.2 Latest version!	Homo sapiens regulator of G protein signaling 10 (RGS10), transcript variant 1, mRNA.	pcDNA3.1-C-(k)DYK or customized vector	in pcDNA3.1-C-(k)DYK	$49.50-$69.30 $99.00
OHu03170	NM_002925.3 Latest version!	Homo sapiens regulator of G protein signaling 10 (RGS10), transcript variant 2, mRNA.	pcDNA3.1-C-(k)DYK or customized vector	7-9	$69.30 $99.00
OHu91560	XM_017016492.1 Latest version!	Homo sapiens regulator of G-protein signaling 10 (RGS10), transcript variant X1, mRNA.	pcDNA3.1-C-(k)DYK or customized vector	9-11	$69.30 $99.00
OHu91561	XM_017016493.1 Latest version!	Homo sapiens regulator of G-protein signaling 10 (RGS10), transcript variant X2, mRNA.	pcDNA3.1-C-(k)DYK or customized vector	9-11	$69.30 $99.00
View Old Accession Versions >>
OHu03666	NM_001005339.1	Homo sapiens regulator of G protein signaling 10 (RGS10), transcript variant 1, mRNA.	pcDNA3.1-C-(k)DYK or customized vector	in pcDNA3.1-C-(k)DYK	$49.50-$69.30 $99.00
Hide Old Accession Versions >>

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** GenScript guarantees 100% sequence accuracy of all synthetic DNA constructs we deliver, but we do not guarantee protein expression in your experimental system. Protein expression is influenced by many factors that may vary between experiments or laboratories. In addition, please pay attention to the signal peptide, propeptide and transit peptide in target ORF, which may affect the choice of vector (N/C terminal tag vector).

***One clone ID might be correlated to multiple accession numbers, which share the same CDS sequence.

Reference Sequences (Refseq)

RGS10 ( NM_001005339.1 ) cDNA ORF clone, Homo sapiens(human) -> NP_001005339.1 Homo sapiens regulator of G protein signaling 10 (RGS10), transcript variant 1, mRNA.

Price & Availability↑

CloneID	OHu03666
Clone ID Related Accession (Same CDS sequence)	NM_001005339.1 , NM_001005339.2
Accession Version	NM_001005339.1	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 546bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2017-09-30
Organism	Homo sapiens(human)
Product	regulator of G-protein signaling 10 isoform a
Comment	Comment: REVIEWED REFSEQ: This record has been curated by NCBI staff. The reference sequence was derived from CB124184.1, BC009361.2, BF685740.1, BM914660.1, BM782346.1, BG763741.1, AL547312.3, CB112318.1 and AI219612.1. Transcript Variant: This variant (1) represents the longer transcript and encodes the longer isoform (a). Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: SRR1163657.348175.1, SRR1163658.345033.1 [ECO:0000332] RNAseq introns :: mixed/partial sample support SAMEA1965299, SAMEA1966682 [ECO:0000350] ##Evidence-Data-END## COMPLETENESS: complete on the 3' end.

ATGTTCAACC GCGCCGTGAG CCGGCTGAGC AGGAAGCGGC CGCCGTCAGA CATCCACGAC 
AGCGATGGCA GTTCCAGCAG CAGCCACCAG AGCCTCAAGA GCACAGCCAA ATGGGCGGCA 
TCCCTGGAGA ATCTGCTGGA AGACCCAGAA GGCGTGAAAA GATTTAGGGA ATTTTTAAAA 
AAGGAATTCA GTGAAGAAAA TGTTTTGTTT TGGCTAGCAT GTGAAGATTT TAAGAAAATG 
CAAGATAAGA CGCAGATGCA GGAAAAGGCA AAGGAGATCT ACATGACCTT TCTGTCCAGC 
AAGGCCTCAT CACAGGTCAA CGTGGAGGGG CAGTCTCGGC TCAACGAGAA GATCCTGGAA 
GAACCGCACC CTCTGATGTT CCAGAAACTC CAGGACCAGA TCTTTAATCT CATGAAGTAC 
GACAGCTACA GCCGCTTCTT AAAGTCTGAC TTGTTTTTAA AACACAAGCG AACCGAGGAA 
GAGGAAGAAG ATTTGCCTGA TGCTCAAACT GCAGCTAAAA GAGCTTCCAG AATTTATAAC 
ACATGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_001005339.1
CDS	73..618
Translation	MFNRAVSRLSRKRPPSDIHDSDGSSSSSHQSLKSTAKWAASLENLLEDPEGVKRFREFLKKEFSEENVLFWLACEDFKKMQDKTQMQEKAKEIYMTFLSSKASSQVNVEGQSRLNEKILEEPHPLMFQKLQDQIFNLMKYDSYSRFLKSDLFLKHKRTEEEEEDLPDAQTAAKRASRIYNT

Target ORF information:

RefSeq Version	NM_001005339.1
Organism	Homo sapiens(human)
Definition	Homo sapiens regulator of G protein signaling 10 (RGS10), transcript variant 1, mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_001005339.1

ORF Insert Sequence:

ATGTTCAACC GCGCCGTGAG CCGGCTGAGC AGGAAGCGGC CGCCGTCAGA CATCCACGAC 
AGCGATGGCA GTTCCAGCAG CAGCCACCAG AGCCTCAAGA GCACAGCCAA ATGGGCGGCA 
TCCCTGGAGA ATCTGCTGGA AGACCCAGAA GGCGTGAAAA GATTTAGGGA ATTTTTAAAA 
AAGGAATTCA GTGAAGAAAA TGTTTTGTTT TGGCTAGCAT GTGAAGATTT TAAGAAAATG 
CAAGATAAGA CGCAGATGCA GGAAAAGGCA AAGGAGATCT ACATGACCTT TCTGTCCAGC 
AAGGCCTCAT CACAGGTCAA CGTGGAGGGG CAGTCTCGGC TCAACGAGAA GATCCTGGAA 
GAACCGCACC CTCTGATGTT CCAGAAACTC CAGGACCAGA TCTTTAATCT CATGAAGTAC 
GACAGCTACA GCCGCTTCTT AAAGTCTGAC TTGTTTTTAA AACACAAGCG AACCGAGGAA 
GAGGAAGAAG ATTTGCCTGA TGCTCAAACT GCAGCTAAAA GAGCTTCCAG AATTTATAAC 
ACATGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RGS10 ( NM_001005339.2 ) cDNA ORF clone, Homo sapiens(human) -> NP_001005339.1 Homo sapiens regulator of G protein signaling 10 (RGS10), transcript variant 1, mRNA.

Price & Availability↑

CloneID	OHu03666
Clone ID Related Accession (Same CDS sequence)	NM_001005339.1 , NM_001005339.2
Accession Version	NM_001005339.2 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 546bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-10-23
Organism	Homo sapiens(human)
Product	regulator of G-protein signaling 10 isoform a
Comment	Comment: REVIEWED REFSEQ: This record has been curated by NCBI staff. The reference sequence was derived from AC012468.10, CB124184.1, BC009361.2, BF685740.1, BM914660.1, BM782346.1, BG763741.1, AL547312.3, CB112318.1, AI219612.1 and AL355273.30. On Nov 22, 2018 this sequence version replaced NM_001005339.1. Transcript Variant: This variant (1) represents the longer transcript and encodes the longer isoform (a). Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: SRR1163655.501958.1, SRR5189661.1739.1 [ECO:0000332] RNAseq introns :: mixed/partial sample support SAMEA1965299, SAMEA1966682 [ECO:0000350] ##Evidence-Data-END## ##RefSeq-Attributes-START## MANE Ensembl match :: ENST00000369103.3/ ENSP00000358099.2 RefSeq Select criteria :: based on conservation, expression, longest protein ##RefSeq-Attributes-END## COMPLETENESS: full length.

ATGTTCAACC GCGCCGTGAG CCGGCTGAGC AGGAAGCGGC CGCCGTCAGA CATCCACGAC 
AGCGATGGCA GTTCCAGCAG CAGCCACCAG AGCCTCAAGA GCACAGCCAA ATGGGCGGCA 
TCCCTGGAGA ATCTGCTGGA AGACCCAGAA GGCGTGAAAA GATTTAGGGA ATTTTTAAAA 
AAGGAATTCA GTGAAGAAAA TGTTTTGTTT TGGCTAGCAT GTGAAGATTT TAAGAAAATG 
CAAGATAAGA CGCAGATGCA GGAAAAGGCA AAGGAGATCT ACATGACCTT TCTGTCCAGC 
AAGGCCTCAT CACAGGTCAA CGTGGAGGGG CAGTCTCGGC TCAACGAGAA GATCCTGGAA 
GAACCGCACC CTCTGATGTT CCAGAAACTC CAGGACCAGA TCTTTAATCT CATGAAGTAC 
GACAGCTACA GCCGCTTCTT AAAGTCTGAC TTGTTTTTAA AACACAAGCG AACCGAGGAA 
GAGGAAGAAG ATTTGCCTGA TGCTCAAACT GCAGCTAAAA GAGCTTCCAG AATTTATAAC 
ACATGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_001005339.1
CDS	82..627
Translation	MFNRAVSRLSRKRPPSDIHDSDGSSSSSHQSLKSTAKWAASLENLLEDPEGVKRFREFLKKEFSEENVLFWLACEDFKKMQDKTQMQEKAKEIYMTFLSSKASSQVNVEGQSRLNEKILEEPHPLMFQKLQDQIFNLMKYDSYSRFLKSDLFLKHKRTEEEEEDLPDAQTAAKRASRIYNT

Target ORF information:

RefSeq Version	NM_001005339.2
Organism	Homo sapiens(human)
Definition	Homo sapiens regulator of G protein signaling 10 (RGS10), transcript variant 1, mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_001005339.2

ORF Insert Sequence:

ATGTTCAACC GCGCCGTGAG CCGGCTGAGC AGGAAGCGGC CGCCGTCAGA CATCCACGAC 
AGCGATGGCA GTTCCAGCAG CAGCCACCAG AGCCTCAAGA GCACAGCCAA ATGGGCGGCA 
TCCCTGGAGA ATCTGCTGGA AGACCCAGAA GGCGTGAAAA GATTTAGGGA ATTTTTAAAA 
AAGGAATTCA GTGAAGAAAA TGTTTTGTTT TGGCTAGCAT GTGAAGATTT TAAGAAAATG 
CAAGATAAGA CGCAGATGCA GGAAAAGGCA AAGGAGATCT ACATGACCTT TCTGTCCAGC 
AAGGCCTCAT CACAGGTCAA CGTGGAGGGG CAGTCTCGGC TCAACGAGAA GATCCTGGAA 
GAACCGCACC CTCTGATGTT CCAGAAACTC CAGGACCAGA TCTTTAATCT CATGAAGTAC 
GACAGCTACA GCCGCTTCTT AAAGTCTGAC TTGTTTTTAA AACACAAGCG AACCGAGGAA 
GAGGAAGAAG ATTTGCCTGA TGCTCAAACT GCAGCTAAAA GAGCTTCCAG AATTTATAAC 
ACATGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RGS10 ( NM_002925.3 ) cDNA ORF clone, Homo sapiens(human) -> NP_002916.1 Homo sapiens regulator of G protein signaling 10 (RGS10), transcript variant 2, mRNA.

Price & Availability↑

CloneID	OHu03170
Clone ID Related Accession (Same CDS sequence)	NM_002925.3
Accession Version	NM_002925.3 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 504bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-10-18
Organism	Homo sapiens(human)
Product	regulator of G-protein signaling 10 isoform b
Comment	Comment: REVIEWED REFSEQ: This record has been curated by NCBI staff. The reference sequence was derived from AV707839.1, BC009361.2, BF685740.1, BM914660.1 and AI219612.1. On Sep 27, 2004 this sequence version replaced NM_002925.2. Transcript Variant: This variant (2) differs in the 5' UTR and coding region compared to variant 1. The resulting isoform (b) is shorter and has a distinct N-terminus compared to isoform a. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: AL547312.3, BI818503.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA2155984 [ECO:0000348] ##Evidence-Data-END## COMPLETENESS: complete on the 3' end.

ATGGAACACA TCCACGACAG CGATGGCAGT TCCAGCAGCA GCCACCAGAG CCTCAAGAGC 
ACAGCCAAAT GGGCGGCATC CCTGGAGAAT CTGCTGGAAG ACCCAGAAGG CGTGAAAAGA 
TTTAGGGAAT TTTTAAAAAA GGAATTCAGT GAAGAAAATG TTTTGTTTTG GCTAGCATGT 
GAAGATTTTA AGAAAATGCA AGATAAGACG CAGATGCAGG AAAAGGCAAA GGAGATCTAC 
ATGACCTTTC TGTCCAGCAA GGCCTCATCA CAGGTCAACG TGGAGGGGCA GTCTCGGCTC 
AACGAGAAGA TCCTGGAAGA ACCGCACCCT CTGATGTTCC AGAAACTCCA GGACCAGATC 
TTTAATCTCA TGAAGTACGA CAGCTACAGC CGCTTCTTAA AGTCTGACTT GTTTTTAAAA 
CACAAGCGAA CCGAGGAAGA GGAAGAAGAT TTGCCTGATG CTCAAACTGC AGCTAAAAGA 
GCTTCCAGAA TTTATAACAC ATGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_002916.1
CDS	64..567
Translation	MEHIHDSDGSSSSSHQSLKSTAKWAASLENLLEDPEGVKRFREFLKKEFSEENVLFWLACEDFKKMQDKTQMQEKAKEIYMTFLSSKASSQVNVEGQSRLNEKILEEPHPLMFQKLQDQIFNLMKYDSYSRFLKSDLFLKHKRTEEEEEDLPDAQTAAKRASRIYNT

Target ORF information:

RefSeq Version	NM_002925.3
Organism	Homo sapiens(human)
Definition	Homo sapiens regulator of G protein signaling 10 (RGS10), transcript variant 2, mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_002925.3

ORF Insert Sequence:

ATGGAACACA TCCACGACAG CGATGGCAGT TCCAGCAGCA GCCACCAGAG CCTCAAGAGC 
ACAGCCAAAT GGGCGGCATC CCTGGAGAAT CTGCTGGAAG ACCCAGAAGG CGTGAAAAGA 
TTTAGGGAAT TTTTAAAAAA GGAATTCAGT GAAGAAAATG TTTTGTTTTG GCTAGCATGT 
GAAGATTTTA AGAAAATGCA AGATAAGACG CAGATGCAGG AAAAGGCAAA GGAGATCTAC 
ATGACCTTTC TGTCCAGCAA GGCCTCATCA CAGGTCAACG TGGAGGGGCA GTCTCGGCTC 
AACGAGAAGA TCCTGGAAGA ACCGCACCCT CTGATGTTCC AGAAACTCCA GGACCAGATC 
TTTAATCTCA TGAAGTACGA CAGCTACAGC CGCTTCTTAA AGTCTGACTT GTTTTTAAAA 
CACAAGCGAA CCGAGGAAGA GGAAGAAGAT TTGCCTGATG CTCAAACTGC AGCTAAAAGA 
GCTTCCAGAA TTTATAACAC ATGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RGS10 ( XM_017016492.1 ) cDNA ORF clone, Homo sapiens(human) -> XP_016871981.1 Homo sapiens regulator of G-protein signaling 10 (RGS10), transcript variant X1, mRNA.

Price & Availability↑

CloneID	OHu91560
Clone ID Related Accession (Same CDS sequence)	XM_017016492.1
Accession Version	XM_017016492.1 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 360bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2016-06-05
Organism	Homo sapiens(human)
Product	regulator of G-protein signaling 10 isoform X1
Comment	Comment: MODEL REFSEQ: This record is predicted by automated computational analysis. This record is derived from a genomic sequence (NC_000010.11) annotated using gene prediction method: Gnomon, supported by EST evidence. Also see: Documentation of NCBI's Annotation Process ##Genome-Annotation-Data-START## Annotation Provider :: NCBI Annotation Status :: Full annotation Annotation Version :: Homo sapiens Annotation Release 108 Annotation Pipeline :: NCBI eukaryotic genome annotation pipeline Annotation Software Version :: 7.0 Annotation Method :: Best-placed RefSeq; Gnomon Features Annotated :: Gene; mRNA; CDS; ncRNA ##Genome-Annotation-Data-END##

ATGGAACACA TCCACGACAG CGATGGCAGT TCCAGCAGCA GCCACCAGAG CCTCAAGAGC 
ACAGCCAAAT GGGCGGCATC CCTGGAGAAT CTGCTGGAAG ACCCAGAAGG CGTGAAAAGA 
TTTAGGGAAT TTTTAAAAAA GGAATTCAGT GAAGAAAATG TTTTGTTTTG GCTAGCATGT 
GAAGATTTTA AGAAAATGCA AGATAAGACG CAGATCTTTA ATCTCATGAA GTACGACAGC 
TACAGCCGCT TCTTAAAGTC TGACTTGTTT TTAAAACACA AGCGAACCGA GGAAGAGGAA 
GAAGATTTGC CTGATGCTCA AACTGCAGCT AAAAGAGCTT CCAGAATTTA TAACACATGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	XP_016871981.1
CDS	112..471
Translation	MEHIHDSDGSSSSSHQSLKSTAKWAASLENLLEDPEGVKRFREFLKKEFSEENVLFWLACEDFKKMQDKTQIFNLMKYDSYSRFLKSDLFLKHKRTEEEEEDLPDAQTAAKRASRIYNT

Target ORF information:

RefSeq Version	XM_017016492.1
Organism	Homo sapiens(human)
Definition	Homo sapiens regulator of G-protein signaling 10 (RGS10), transcript variant X1, mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

XM_017016492.1

ORF Insert Sequence:

ATGGAACACA TCCACGACAG CGATGGCAGT TCCAGCAGCA GCCACCAGAG CCTCAAGAGC 
ACAGCCAAAT GGGCGGCATC CCTGGAGAAT CTGCTGGAAG ACCCAGAAGG CGTGAAAAGA 
TTTAGGGAAT TTTTAAAAAA GGAATTCAGT GAAGAAAATG TTTTGTTTTG GCTAGCATGT 
GAAGATTTTA AGAAAATGCA AGATAAGACG CAGATCTTTA ATCTCATGAA GTACGACAGC 
TACAGCCGCT TCTTAAAGTC TGACTTGTTT TTAAAACACA AGCGAACCGA GGAAGAGGAA 
GAAGATTTGC CTGATGCTCA AACTGCAGCT AAAAGAGCTT CCAGAATTTA TAACACATGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RGS10 ( XM_017016493.1 ) cDNA ORF clone, Homo sapiens(human) -> XP_016871982.1 Homo sapiens regulator of G-protein signaling 10 (RGS10), transcript variant X2, mRNA.

Price & Availability↑

CloneID	OHu91561
Clone ID Related Accession (Same CDS sequence)	XM_017016493.1
Accession Version	XM_017016493.1 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 402bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2016-06-05
Organism	Homo sapiens(human)
Product	regulator of G-protein signaling 10 isoform X2
Comment	Comment: MODEL REFSEQ: This record is predicted by automated computational analysis. This record is derived from a genomic sequence (NC_000010.11) annotated using gene prediction method: Gnomon, supported by EST evidence. Also see: Documentation of NCBI's Annotation Process ##Genome-Annotation-Data-START## Annotation Provider :: NCBI Annotation Status :: Full annotation Annotation Version :: Homo sapiens Annotation Release 108 Annotation Pipeline :: NCBI eukaryotic genome annotation pipeline Annotation Software Version :: 7.0 Annotation Method :: Best-placed RefSeq; Gnomon Features Annotated :: Gene; mRNA; CDS; ncRNA ##Genome-Annotation-Data-END##

ATGTTCAACC GCGCCGTGAG CCGGCTGAGC AGGAAGCGGC CGCCGTCAGA CATCCACGAC 
AGCGATGGCA GTTCCAGCAG CAGCCACCAG AGCCTCAAGA GCACAGCCAA ATGGGCGGCA 
TCCCTGGAGA ATCTGCTGGA AGACCCAGAA GGCGTGAAAA GATTTAGGGA ATTTTTAAAA 
AAGGAATTCA GTGAAGAAAA TGTTTTGTTT TGGCTAGCAT GTGAAGATTT TAAGAAAATG 
CAAGATAAGA CGCAGATCTT TAATCTCATG AAGTACGACA GCTACAGCCG CTTCTTAAAG 
TCTGACTTGT TTTTAAAACA CAAGCGAACC GAGGAAGAGG AAGAAGATTT GCCTGATGCT 
CAAACTGCAG CTAAAAGAGC TTCCAGAATT TATAACACAT GA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	XP_016871982.1
CDS	115..516
Translation	MFNRAVSRLSRKRPPSDIHDSDGSSSSSHQSLKSTAKWAASLENLLEDPEGVKRFREFLKKEFSEENVLFWLACEDFKKMQDKTQIFNLMKYDSYSRFLKSDLFLKHKRTEEEEEDLPDAQTAAKRASRIYNT

Target ORF information:

RefSeq Version	XM_017016493.1
Organism	Homo sapiens(human)
Definition	Homo sapiens regulator of G-protein signaling 10 (RGS10), transcript variant X2, mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

XM_017016493.1

ORF Insert Sequence:

ATGTTCAACC GCGCCGTGAG CCGGCTGAGC AGGAAGCGGC CGCCGTCAGA CATCCACGAC 
AGCGATGGCA GTTCCAGCAG CAGCCACCAG AGCCTCAAGA GCACAGCCAA ATGGGCGGCA 
TCCCTGGAGA ATCTGCTGGA AGACCCAGAA GGCGTGAAAA GATTTAGGGA ATTTTTAAAA 
AAGGAATTCA GTGAAGAAAA TGTTTTGTTT TGGCTAGCAT GTGAAGATTT TAAGAAAATG 
CAAGATAAGA CGCAGATCTT TAATCTCATG AAGTACGACA GCTACAGCCG CTTCTTAAAG 
TCTGACTTGT TTTTAAAACA CAAGCGAACC GAGGAAGAGG AAGAAGATTT GCCTGATGCT 
CAAACTGCAG CTAAAAGAGC TTCCAGAATT TATAACACAT GA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

PubMed

Suppression of the GTPase-activating protein RGS10 increases Rheb-GTP and mTOR signaling in ovarian cancer cells.
Cancer letters369(1)175-83(2015 Dec)
Altman MK,Alshamrani AA,Jia W,Nguyen HT,Fambrough JM,Tran SK,Patel MB,Hoseinzadeh P,Beedle AM,Murph MM

Cellular deficiency in the RGS10 protein facilitates chemoresistant ovarian cancer.
Future medicinal chemistry7(12)1483-9(2015 Aug)
Hooks SB,Murph MM

Inhibition of HDAC1 and DNMT1 modulate RGS10 expression and decrease ovarian cancer chemoresistance.
PloS one9(1)e87455(2014)
Cacan E,Ali MW,Boyd NH,Hooks SB,Greer SF

Brain RGS4 and RGS10 protein expression in schizophrenia and depression. Effect of drug treatment.
Psychopharmacology226(1)177-88(2013 Mar)
Rivero G,Gabilondo AM,Garc?a-Sevilla JA,Callado LF,La Harpe R,Morentin B,Meana JJ

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RGS10 cDNA ORF clone, Homo sapiens(human)

Gene

Clones

gRNAs

Related articles in PubMed

Target ORF information:

Target ORF information:

ORF Insert Sequence:

Target ORF information:

Target ORF information:

ORF Insert Sequence:

Target ORF information:

Target ORF information:

ORF Insert Sequence:

Target ORF information:

Target ORF information:

ORF Insert Sequence:

Target ORF information:

Target ORF information:

ORF Insert Sequence:

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