Gene Symbol | REST |
Entrez Gene ID | 5978 |
Full Name | RE1 silencing transcription factor |
Synonyms | GINGF5,HGF5,NRSF,WT6,XBR |
General protein information |
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Gene Type | protein-coding |
Organism | Homo sapiens(human) |
Genome | |
Summary | This gene encodes a transcriptional repressor that represses neuronal genes in non-neuronal tissues. It is a member of the Kruppel-type zinc finger transcription factor family. It represses transcription by binding a DNA sequence element called the neuron-restrictive silencer element. The protein is also found in undifferentiated neuronal progenitor cells and it is thought that this repressor may act as a master negative regular of neurogenesis. Alternatively spliced transcript variants have been described [provided by RefSeq, Jul 2010]. |
Disorder MIM: | |
Disorder Html: | {Wilms tumor 6, susceptibility to}, 616806 (3); Fibromatosis, gingival, 5, 617626 (3) |