RARRES3 cDNA ORF clone, Homo sapiens(human)

Gene
Clones
gRNAs

Summary

Gene Symbol	RARRES3
Entrez Gene ID	5920
Full Name	retinoic acid receptor responder 3
Synonyms	HRASLS4,HRSL4,PLA1/2-3,RIG1,TIG3
General protein information	Preferred Names retinoic acid receptor responder 3 Names retinoic acid receptor responder protein 3 HRAS-like suppressor 4 RAR-responsive protein TIG3 retinoic acid receptor responder (tazarotene induced) 3 retinoic acid-inducible gene 1 retinoid-inducible gene 1 protein tazarotene-induced gene 3 protein
Gene Type	protein-coding
Organism	Homo sapiens(human)
Genome	Chromosome: 11 Map Location: 11q12.3
Summary	Retinoids exert biologic effects such as potent growth inhibitory and cell differentiation activities and are used in the treatment of hyperproliferative dermatological diseases. These effects are mediated by specific nuclear receptor proteins that are members of the steroid and thyroid hormone receptor superfamily of transcriptional regulators. RARRES1, RARRES2, and RARRES3 are genes whose expression is upregulated by the synthetic retinoid tazarotene. RARRES3 is thought act as a tumor suppressor or growth regulator. [provided by RefSeq, Jul 2008].
Disorder MIM:	605092

mRNA and Protein(s)

mRNA	Protein	Name
NM_004585.5	NP_004576.2	phospholipase A and acyltransferase 4
NM_004585.4	NP_004576.2	retinoic acid receptor responder protein 3

Pathways from BioSystems

Homologies

Homo sapiens (human)	RARRES3	NP_004576.2
Danio rerio (zebrafish)	zgc:92249	NP_001002623.1
Canis lupus familiaris (dog)	RARRES3	XP_005631639.1
	LOC722189	XP_001118373.1
Danio rerio (zebrafish)	LOC100330001	XP_002664517.1
Pan troglodytes (chimpanzee)	RARRES3	XP_508513.2

Gene Ontology
Bibliography

Related articles in PubMed

Histone methyltransferase G9a promotes liver cancer development by epigenetic silencing of tumor suppressor gene RARRES3.
Wei L, Chiu DK, Tsang FH, Law CT, Cheng CL, Au SL, Lee JM, Wong CC, Ng IO, Wong CM
Journal of hepatology67(4)758-769(2017 Oct)

High expression of TIG3 predicts poor survival in patients with primary glioblastoma.
Wang H, Xu H, Xu T, Tan C, Jiang M, Chen Y, Hu X, Zhou J, Shen J, Qin R, Hu D, Huang Q, Wang M, Wang L, Duan D, Yan Y, Chen J
Tumour biology : the journal of the International Society for Oncodevelopmental Biology and Medicine39(6)1010428317712135(2017 Jun)

RNA virus receptor Rig-I monitors gut microbiota and inhibits colitis-associated colorectal cancer.
Zhu H, Xu WY, Hu Z, Zhang H, Shen Y, Lu S, Wei C, Wang ZG
Journal of experimental & clinical cancer research : CR36(1)2(2017 Jan)

Foot-and-Mouth Disease Virus Viroporin 2B Antagonizes RIG-I-Mediated Antiviral Effects by Inhibition of Its Protein Expression.
Zhu Z, Wang G, Yang F, Cao W, Mao R, Du X, Zhang X, Li C, Li D, Zhang K, Shu H, Liu X, Zheng H
Journal of virology90(24)11106-11121(2016 Dec)

GeneRIFs: Gene References Into Functions What's a GeneRIF?

this study indicated that increased expression of TIG3 in primary glioblastoma is a novel biomarker for predicting poor outcome of patients. We then hypothesize that TIG3 may function in a different pattern in glioblastoma
Title: High expression of TIG3 predicts poor survival in patients with primary glioblastoma.

Study uncovered a novel aspect of Rig-I in monitoring gut microbiota through regulating IgA and IL6-STAT3-dependent Reg3gamma pathway. Besides, Rig-I loss could also promote colorectal cancer progression both in the presence and absence of intestinal bacteria.
Title: RNA virus receptor Rig-I monitors gut microbiota and inhibits colitis-associated colorectal cancer.

Foot-and-mouth disease virus Viroporin 2B antagonizes RIG-I-mediated antiviral effects by inhibition of its protein expression.
Title: Foot-and-Mouth Disease Virus Viroporin 2B Antagonizes RIG-I-Mediated Antiviral Effects by Inhibition of Its Protein Expression.

this review describes antiviral activities of RIG-I against influenza viruses (standing on three legs)
Title: Standing on three legs: antiviral activities of RIG-I against influenza viruses.

a novel mechanism of pattern recognition receptor modulation by HCV and suggests a biological function of the HCV alternate reading frame in the modulation of host innate immunity
Title: Hepatitis C Virus Frameshift/Alternate Reading Frame Protein Suppresses Interferon Responses Mediated by Pattern Recognition Receptor Retinoic-Acid-Inducible Gene-I.

The following RARRES3 gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the RARRES3 cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1⁺/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.

***CloneID	Accession No.	Definition	**Vector	*Turnaround time	Price (USD)
OHu15562	NM_004585.5 Latest version!	Homo sapiens phospholipase A and acyltransferase 4 (PLAAT4), mRNA.	pcDNA3.1-C-(k)DYK or customized vector	in pcDNA3.1-C-(k)DYK	$49.50-$69.30 $99.00
View Old Accession Versions >>
OHu15562	NM_004585.4	Homo sapiens retinoic acid receptor responder 3 (RARRES3), mRNA.	pcDNA3.1-C-(k)DYK or customized vector	in pcDNA3.1-C-(k)DYK	$49.50-$69.30 $99.00
Hide Old Accession Versions >>

ORF Online Only Promotion

Next-day Shipping ORF Clones ( in default vector with tag)
1 Clone	30% OFF
2-4 Clone	40% OFF
5 or more Clone	50% OFF
All Other ORF Clones
30% OFF

*Business Day

** You may select a custom vector to replace pcDNA3.1+/C-(K)DYK after clone is added to cart.

** GenScript guarantees 100% sequence accuracy of all synthetic DNA constructs we deliver, but we do not guarantee protein expression in your experimental system. Protein expression is influenced by many factors that may vary between experiments or laboratories. In addition, please pay attention to the signal peptide, propeptide and transit peptide in target ORF, which may affect the choice of vector (N/C terminal tag vector).

***One clone ID might be correlated to multiple accession numbers, which share the same CDS sequence.

Reference Sequences (Refseq)

RARRES3 ( NM_004585.5 ) cDNA ORF clone, Homo sapiens(human) -> NP_004576.2 Homo sapiens phospholipase A and acyltransferase 4 (PLAAT4), mRNA.

Price & Availability↑

CloneID	OHu15562
Clone ID Related Accession (Same CDS sequence)	NM_004585.5 , NM_004585.4
Accession Version	NM_004585.5 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 495bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-09-26
Organism	Homo sapiens(human)
Product	phospholipase A and acyltransferase 4
Comment	Comment: VALIDATED REFSEQ: This record has undergone validation or preliminary review. The reference sequence was derived from DA973023.1, BC009678.1 and KF455398.1. On Nov 23, 2018 this sequence version replaced NM_004585.4. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: AF092922.1, BU598144.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA1965299, SAMEA1966682 [ECO:0000348] ##Evidence-Data-END## ##RefSeq-Attributes-START## MANE Ensembl match :: ENST00000255688.8/ ENSP00000255688.3 RefSeq Select criteria :: based on single protein-coding transcript ##RefSeq-Attributes-END## COMPLETENESS: full length.

ATGGCTTCGC CACACCAAGA GCCCAAACCT GGAGACCTGA TTGAGATTTT CCGCCTTGGC 
TATGAGCACT GGGCCCTGTA TATAGGAGAT GGCTACGTGA TCCATCTGGC TCCTCCAAGT 
GAGTACCCCG GGGCTGGCTC CTCCAGTGTC TTCTCAGTCC TGAGCAACAG TGCAGAGGTG 
AAACGGGAGC GCCTGGAAGA TGTGGTGGGA GGCTGTTGCT ATCGGGTCAA CAACAGCTTG 
GACCATGAGT ACCAACCACG GCCCGTGGAG GTGATCATCA GTTCTGCGAA GGAGATGGTT 
GGTCAGAAGA TGAAGTACAG TATTGTGAGC AGGAACTGTG AGCACTTTGT CACCCAGCTG 
AGATATGGCA AGTCCCGCTG TAAACAGGTG GAAAAGGCCA AGGTTGAAGT CGGTGTGGCC 
ACGGCGCTTG GAATCCTGGT TGTTGCTGGA TGCTCTTTTG CGATTAGGAG ATACCAAAAA 
AAAGCGACAG CCTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_004576.2
CDS	62..556
Translation	MASPHQEPKPGDLIEIFRLGYEHWALYIGDGYVIHLAPPSEYPGAGSSSVFSVLSNSAEVKRERLEDVVGGCCYRVNNSLDHEYQPRPVEVIISSAKEMVGQKMKYSIVSRNCEHFVTQLRYGKSRCKQVEKAKVEVGVATALGILVVAGCSFAIRRYQKKATA

Target ORF information:

RefSeq Version	NM_004585.5
Organism	Homo sapiens(human)
Definition	Homo sapiens phospholipase A and acyltransferase 4 (PLAAT4), mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_004585.5

ORF Insert Sequence:

ATGGCTTCGC CACACCAAGA GCCCAAACCT GGAGACCTGA TTGAGATTTT CCGCCTTGGC 
TATGAGCACT GGGCCCTGTA TATAGGAGAT GGCTACGTGA TCCATCTGGC TCCTCCAAGT 
GAGTACCCCG GGGCTGGCTC CTCCAGTGTC TTCTCAGTCC TGAGCAACAG TGCAGAGGTG 
AAACGGGAGC GCCTGGAAGA TGTGGTGGGA GGCTGTTGCT ATCGGGTCAA CAACAGCTTG 
GACCATGAGT ACCAACCACG GCCCGTGGAG GTGATCATCA GTTCTGCGAA GGAGATGGTT 
GGTCAGAAGA TGAAGTACAG TATTGTGAGC AGGAACTGTG AGCACTTTGT CACCCAGCTG 
AGATATGGCA AGTCCCGCTG TAAACAGGTG GAAAAGGCCA AGGTTGAAGT CGGTGTGGCC 
ACGGCGCTTG GAATCCTGGT TGTTGCTGGA TGCTCTTTTG CGATTAGGAG ATACCAAAAA 
AAAGCGACAG CCTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RARRES3 ( NM_004585.4 ) cDNA ORF clone, Homo sapiens(human) -> NP_004576.2 Homo sapiens retinoic acid receptor responder 3 (RARRES3), mRNA.

Price & Availability↑

CloneID	OHu15562
Clone ID Related Accession (Same CDS sequence)	NM_004585.5 , NM_004585.4
Accession Version	NM_004585.4	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 495bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2017-12-28
Organism	Homo sapiens(human)
Product	retinoic acid receptor responder protein 3
Comment	Comment: VALIDATED REFSEQ: This record has undergone validation or preliminary review. The reference sequence was derived from DA973023.1, BC009678.1 and KF455398.1. On Jan 17, 2014 this sequence version replaced NM_004585.3. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: AF092922.1, SRR1163657.290896.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA1965299, SAMEA1966682 [ECO:0000348] ##Evidence-Data-END## COMPLETENESS: complete on the 3' end.

ATGGCTTCGC CACACCAAGA GCCCAAACCT GGAGACCTGA TTGAGATTTT CCGCCTTGGC 
TATGAGCACT GGGCCCTGTA TATAGGAGAT GGCTACGTGA TCCATCTGGC TCCTCCAAGT 
GAGTACCCCG GGGCTGGCTC CTCCAGTGTC TTCTCAGTCC TGAGCAACAG TGCAGAGGTG 
AAACGGGAGC GCCTGGAAGA TGTGGTGGGA GGCTGTTGCT ATCGGGTCAA CAACAGCTTG 
GACCATGAGT ACCAACCACG GCCCGTGGAG GTGATCATCA GTTCTGCGAA GGAGATGGTT 
GGTCAGAAGA TGAAGTACAG TATTGTGAGC AGGAACTGTG AGCACTTTGT CACCCAGCTG 
AGATATGGCA AGTCCCGCTG TAAACAGGTG GAAAAGGCCA AGGTTGAAGT CGGTGTGGCC 
ACGGCGCTTG GAATCCTGGT TGTTGCTGGA TGCTCTTTTG CGATTAGGAG ATACCAAAAA 
AAAGCGACAG CCTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_004576.2
CDS	69..563
Translation	MASPHQEPKPGDLIEIFRLGYEHWALYIGDGYVIHLAPPSEYPGAGSSSVFSVLSNSAEVKRERLEDVVGGCCYRVNNSLDHEYQPRPVEVIISSAKEMVGQKMKYSIVSRNCEHFVTQLRYGKSRCKQVEKAKVEVGVATALGILVVAGCSFAIRRYQKKATA

Target ORF information:

RefSeq Version	NM_004585.4
Organism	Homo sapiens(human)
Definition	Homo sapiens retinoic acid receptor responder 3 (RARRES3), mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_004585.4

ORF Insert Sequence:

ATGGCTTCGC CACACCAAGA GCCCAAACCT GGAGACCTGA TTGAGATTTT CCGCCTTGGC 
TATGAGCACT GGGCCCTGTA TATAGGAGAT GGCTACGTGA TCCATCTGGC TCCTCCAAGT 
GAGTACCCCG GGGCTGGCTC CTCCAGTGTC TTCTCAGTCC TGAGCAACAG TGCAGAGGTG 
AAACGGGAGC GCCTGGAAGA TGTGGTGGGA GGCTGTTGCT ATCGGGTCAA CAACAGCTTG 
GACCATGAGT ACCAACCACG GCCCGTGGAG GTGATCATCA GTTCTGCGAA GGAGATGGTT 
GGTCAGAAGA TGAAGTACAG TATTGTGAGC AGGAACTGTG AGCACTTTGT CACCCAGCTG 
AGATATGGCA AGTCCCGCTG TAAACAGGTG GAAAAGGCCA AGGTTGAAGT CGGTGTGGCC 
ACGGCGCTTG GAATCCTGGT TGTTGCTGGA TGCTCTTTTG CGATTAGGAG ATACCAAAAA 
AAAGCGACAG CCTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

PubMed

Histone methyltransferase G9a promotes liver cancer development by epigenetic silencing of tumor suppressor gene RARRES3.
Journal of hepatology67(4)758-769(2017 Oct)
Wei L,Chiu DK,Tsang FH,Law CT,Cheng CL,Au SL,Lee JM,Wong CC,Ng IO,Wong CM

High expression of TIG3 predicts poor survival in patients with primary glioblastoma.
Tumour biology : the journal of the International Society for Oncodevelopmental Biology and Medicine39(6)1010428317712135(2017 Jun)
Wang H,Xu H,Xu T,Tan C,Jiang M,Chen Y,Hu X,Zhou J,Shen J,Qin R,Hu D,Huang Q,Wang M,Wang L,Duan D,Yan Y,Chen J

RNA virus receptor Rig-I monitors gut microbiota and inhibits colitis-associated colorectal cancer.
Journal of experimental & clinical cancer research : CR36(1)2(2017 Jan)
Zhu H,Xu WY,Hu Z,Zhang H,Shen Y,Lu S,Wei C,Wang ZG

Foot-and-Mouth Disease Virus Viroporin 2B Antagonizes RIG-I-Mediated Antiviral Effects by Inhibition of Its Protein Expression.
Journal of virology90(24)11106-11121(2016 Dec)
Zhu Z,Wang G,Yang F,Cao W,Mao R,Du X,Zhang X,Li C,Li D,Zhang K,Shu H,Liu X,Zheng H

- Most Popular Services
  - 人工遺伝子合成& DNA合成-納期保証
- Services & Products

見積依頼

Eメール

japanmarket@genscript.com

電話

03-6811-6572

FAX

03-6811-6573
050-3174-7589(受注専用)

オンラインフォーム

オンライン注文

RARRES3 cDNA ORF clone, Homo sapiens(human)

Gene

Clones

gRNAs

Related articles in PubMed

Target ORF information:

Target ORF information:

ORF Insert Sequence:

Target ORF information:

Target ORF information:

ORF Insert Sequence:

Most Popular Services

Services & Products

見積依頼

Eメール

電話

FAX

オンラインフォーム

サポート

会社情報

サポート

会社情報