IL21 cDNA ORF clone, Homo sapiens(human)

Gene
Clones
gRNAs

Summary

Gene Symbol	IL21
Entrez Gene ID	59067
Full Name	interleukin 21
Synonyms	CVID11,IL-21,Za11
General protein information	Preferred Names interleukin 21 Names interleukin-21 interleukin-21 isoform
Gene Type	protein-coding
Organism	Homo sapiens(human)
Genome	Chromosome: 4 Map Location: 4q27
Summary	This gene encodes a member of the common-gamma chain family of cytokines with immunoregulatory activity. The encoded protein plays a role in both the innate and adaptive immune responses by inducing the differentiation, proliferation and activity of multiple target cells including macrophages, natural killer cells, B cells and cytotoxic T cells. Dysregulation of this gene plays a role in multiple immune-mediated diseases including lupus, psoriasis and chronic inflammatory diseases. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene. [provided by RefSeq, Dec 2011].
Disorder MIM:	605384
Disorder Html:	?Immunodeficiency, common variable, 11, 615767 (3)

mRNA and Protein(s)

mRNA	Protein	Name
NM_021803.4	NP_068575.1	interleukin-21 isoform 1 precursor
NM_001207006.2	NP_001193935.1	interleukin-21 isoform 2 precursor
NM_021803.3	NP_068575.1	interleukin-21 isoform 1 precursor

Pathways from BioSystems

Homologies

Canis lupus familiaris (dog)	IL21	NP_001003347.1
Rattus norvegicus (Norway rat)	Il21	NP_001102413.1
Pan troglodytes (chimpanzee)	IL21	XP_526677.2
Bos taurus (cattle)	IL21	NP_942129.1
	IL21	XP_001103613.1
Homo sapiens (human)	IL21	NP_068575.1
Mus musculus (house mouse)	Il21	NP_068554.1

Gene Ontology
Bibliography

Related articles in PubMed

IL-21 Is Increased in Nasal Polyposis and after Stimulation with Staphylococcus aureus Enterotoxin B.
Calus L, Derycke L, Dullaers M, Van Zele T, De Ruyck N, P?rez-Novo C, Holtappels G, De Vos G, Lambrecht BN, Bachert C, Gevaert P
International archives of allergy and immunology174(3-4)161-169(2017)

GeneRIFs: Gene References Into Functions What's a GeneRIF?

Report efficient retroviral vector transduction of primary human natural killer cells that were stimulated by a combination of IL-2 and engineered K562 cells expressing membrane-bound IL-21 for cancer immunotherapy.
Title: Retroviral gene transfer into primary human NK cells activated by IL-2 and K562 feeder cells expressing membrane-bound IL-21.

These results indicate that significant increased IL-21 expression present within the adenoma/CRC microenvironment might have a potential predicating significance for survival time in patients with CRC.
Title: Increased expression of interleukin-21 along colorectal adenoma-carcinoma sequence and its predicating significance in patients with sporadic colorectal cancer.

IL21 reduction in osteosarcoma patients due to PD-1 and pd-L1 mediated follicular helper T cells suppression.
Title: Evidence of Interleukin 21 Reduction in Osteosarcoma Patients Due to PD-1/PD-L1-Mediated Suppression of Follicular Helper T Cell Functionality.

the elevated level of IL-2+ and IL-21+ T cells and a positive correlation between IL-21+ cells with clinical activity index in ulcerative colitis patients may contribute to the pathogenesis of disease.
Title: Elevated levels of IL-2 and IL-21 produced by CD4+ T cells in inflammatory bowel disease.

IL-21 are important in the pathophysiology of chronic rhinosinusitis with nasal polyposis
Title: IL-21 Is Increased in Nasal Polyposis and after Stimulation with Staphylococcus aureus Enterotoxin B.

The following IL21 gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the IL21 cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1⁺/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.

***CloneID	Accession No.	Definition	**Vector	*Turnaround time	Price (USD)
OHu26496	NM_001207006.2 Latest version!	Homo sapiens interleukin 21 (IL21), transcript variant 2, mRNA.	pcDNA3.1-C-(k)DYK or customized vector	in pcDNA3.1-C-(k)DYK	$49.50-$69.30 $99.00
OHu26552	NM_021803.4 Latest version!	Homo sapiens interleukin 21 (IL21), transcript variant 1, mRNA.	pcDNA3.1-C-(k)DYK or customized vector	in pcDNA3.1-C-(k)DYK	$49.50-$69.30 $99.00
View Old Accession Versions >>
OHu26552	NM_021803.3	Homo sapiens interleukin 21 (IL21), transcript variant 1, mRNA.	pcDNA3.1-C-(k)DYK or customized vector	in pcDNA3.1-C-(k)DYK	$49.50-$69.30 $99.00
Hide Old Accession Versions >>

ORF Online Only Promotion

Next-day Shipping ORF Clones ( in default vector with tag)
1 Clone	30% OFF
2-4 Clone	40% OFF
5 or more Clone	50% OFF
All Other ORF Clones
30% OFF

*Business Day

** You may select a custom vector to replace pcDNA3.1+/C-(K)DYK after clone is added to cart.

** GenScript guarantees 100% sequence accuracy of all synthetic DNA constructs we deliver, but we do not guarantee protein expression in your experimental system. Protein expression is influenced by many factors that may vary between experiments or laboratories. In addition, please pay attention to the signal peptide, propeptide and transit peptide in target ORF, which may affect the choice of vector (N/C terminal tag vector).

***One clone ID might be correlated to multiple accession numbers, which share the same CDS sequence.

Reference Sequences (Refseq)

IL21 ( NM_001207006.2 ) cDNA ORF clone, Homo sapiens(human) -> NP_001193935.1 Homo sapiens interleukin 21 (IL21), transcript variant 2, mRNA.

Price & Availability↑

CloneID	OHu26496
Clone ID Related Accession (Same CDS sequence)	NM_001207006.2
Accession Version	NM_001207006.2 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 462bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-12-27
Organism	Homo sapiens(human)
Product	interleukin-21 isoform 2 precursor
Comment	Comment: REVIEWED REFSEQ: This record has been curated by NCBI staff. The reference sequence was derived from AF254069.1, DQ645417.1, CD559613.2 and BC069124.1. On Dec 23, 2011 this sequence version replaced NM_001207006.1. Transcript Variant: This variant (2) retains an intron compared to variant 1. The resulting isoform (2) has a shorter and distinct C-terminus compared to isoform 1. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: DQ645417.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA1965299, SAMEA1966682 [ECO:0000348] ##Evidence-Data-END##

ATGAGATCCA GTCCTGGCAA CATGGAGAGG ATTGTCATCT GTCTGATGGT CATCTTCTTG 
GGGACACTGG TCCACAAATC AAGCTCCCAA GGTCAAGATC GCCACATGAT TAGAATGCGT 
CAACTTATAG ATATTGTTGA TCAGCTGAAA AATTATGTGA ATGACTTGGT CCCTGAATTT 
CTGCCAGCTC CAGAAGATGT AGAGACAAAC TGTGAGTGGT CAGCTTTTTC CTGCTTTCAG 
AAGGCCCAAC TAAAGTCAGC AAATACAGGA AACAATGAAA GGATAATCAA TGTATCAATT 
AAAAAGCTGA AGAGGAAACC ACCTTCCACA AATGCAGGGA GAAGACAGAA ACACAGACTA 
ACATGCCCTT CATGTGATTC TTATGAGAAA AAACCACCCA AAGAATTCCT AGAAAGATTC 
AAATCACTTC TCCAAAAGGT ATCTACCTTA AGTTTCATTT GA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_001193935.1
CDS	47..508
Translation	MRSSPGNMERIVICLMVIFLGTLVHKSSSQGQDRHMIRMRQLIDIVDQLKNYVNDLVPEFLPAPEDVETNCEWSAFSCFQKAQLKSANTGNNERIINVSIKKLKRKPPSTNAGRRQKHRLTCPSCDSYEKKPPKEFLERFKSLLQKVSTLSFI

Target ORF information:

RefSeq Version	NM_001207006.2
Organism	Homo sapiens(human)
Definition	Homo sapiens interleukin 21 (IL21), transcript variant 2, mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_001207006.2

ORF Insert Sequence:

ATGAGATCCA GTCCTGGCAA CATGGAGAGG ATTGTCATCT GTCTGATGGT CATCTTCTTG 
GGGACACTGG TCCACAAATC AAGCTCCCAA GGTCAAGATC GCCACATGAT TAGAATGCGT 
CAACTTATAG ATATTGTTGA TCAGCTGAAA AATTATGTGA ATGACTTGGT CCCTGAATTT 
CTGCCAGCTC CAGAAGATGT AGAGACAAAC TGTGAGTGGT CAGCTTTTTC CTGCTTTCAG 
AAGGCCCAAC TAAAGTCAGC AAATACAGGA AACAATGAAA GGATAATCAA TGTATCAATT 
AAAAAGCTGA AGAGGAAACC ACCTTCCACA AATGCAGGGA GAAGACAGAA ACACAGACTA 
ACATGCCCTT CATGTGATTC TTATGAGAAA AAACCACCCA AAGAATTCCT AGAAAGATTC 
AAATCACTTC TCCAAAAGGT ATCTACCTTA AGTTTCATTT GA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

IL21 ( NM_021803.4 ) cDNA ORF clone, Homo sapiens(human) -> NP_068575.1 Homo sapiens interleukin 21 (IL21), transcript variant 1, mRNA.

Price & Availability↑

CloneID	OHu26552
Clone ID Related Accession (Same CDS sequence)	NM_021803.4 , NM_021803.3
Accession Version	NM_021803.4 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 489bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-12-26
Organism	Homo sapiens(human)
Product	interleukin-21 isoform 1 precursor
Comment	Comment: REVIEWED REFSEQ: This record has been curated by NCBI staff. The reference sequence was derived from AC053545.5, AF254069.1, BC069124.1 and LC133256.1. This sequence is a reference standard in the RefSeqGene project. On Jul 31, 2018 this sequence version replaced NM_021803.3. Transcript Variant: This variant (1) encodes the longer isoform (1). Sequence Note: This RefSeq record was created from transcript and genomic sequence data to make the sequence consistent with the reference genome assembly. The genomic coordinates used for the transcript record were based on transcript alignments. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: LC133256.1, BC069124.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA1965299, SAMEA1966682 [ECO:0000348] ##Evidence-Data-END## ##RefSeq-Attributes-START## MANE Ensembl match :: ENST00000648588.1/ ENSP00000497915.1 RefSeq Select criteria :: based on manual assertion, conservation, expression, longest protein ##RefSeq-Attributes-END##

ATGAGATCCA GTCCTGGCAA CATGGAGAGG ATTGTCATCT GTCTGATGGT CATCTTCTTG 
GGGACACTGG TCCACAAATC AAGCTCCCAA GGTCAAGATC GCCACATGAT TAGAATGCGT 
CAACTTATAG ATATTGTTGA TCAGCTGAAA AATTATGTGA ATGACTTGGT CCCTGAATTT 
CTGCCAGCTC CAGAAGATGT AGAGACAAAC TGTGAGTGGT CAGCTTTTTC CTGCTTTCAG 
AAGGCCCAAC TAAAGTCAGC AAATACAGGA AACAATGAAA GGATAATCAA TGTATCAATT 
AAAAAGCTGA AGAGGAAACC ACCTTCCACA AATGCAGGGA GAAGACAGAA ACACAGACTA 
ACATGCCCTT CATGTGATTC TTATGAGAAA AAACCACCCA AAGAATTCCT AGAAAGATTC 
AAATCACTTC TCCAAAAGAT GATTCATCAG CATCTGTCCT CTAGAACACA CGGAAGTGAA 
GATTCCTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_068575.1
CDS	56..544
Translation	MRSSPGNMERIVICLMVIFLGTLVHKSSSQGQDRHMIRMRQLIDIVDQLKNYVNDLVPEFLPAPEDVETNCEWSAFSCFQKAQLKSANTGNNERIINVSIKKLKRKPPSTNAGRRQKHRLTCPSCDSYEKKPPKEFLERFKSLLQKMIHQHLSSRTHGSEDS

Target ORF information:

RefSeq Version	NM_021803.4
Organism	Homo sapiens(human)
Definition	Homo sapiens interleukin 21 (IL21), transcript variant 1, mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_021803.4

ORF Insert Sequence:

ATGAGATCCA GTCCTGGCAA CATGGAGAGG ATTGTCATCT GTCTGATGGT CATCTTCTTG 
GGGACACTGG TCCACAAATC AAGCTCCCAA GGTCAAGATC GCCACATGAT TAGAATGCGT 
CAACTTATAG ATATTGTTGA TCAGCTGAAA AATTATGTGA ATGACTTGGT CCCTGAATTT 
CTGCCAGCTC CAGAAGATGT AGAGACAAAC TGTGAGTGGT CAGCTTTTTC CTGCTTTCAG 
AAGGCCCAAC TAAAGTCAGC AAATACAGGA AACAATGAAA GGATAATCAA TGTATCAATT 
AAAAAGCTGA AGAGGAAACC ACCTTCCACA AATGCAGGGA GAAGACAGAA ACACAGACTA 
ACATGCCCTT CATGTGATTC TTATGAGAAA AAACCACCCA AAGAATTCCT AGAAAGATTC 
AAATCACTTC TCCAAAAGAT GATTCATCAG CATCTGTCCT CTAGAACACA CGGAAGTGAA 
GATTCCTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

IL21 ( NM_021803.3 ) cDNA ORF clone, Homo sapiens(human) -> NP_068575.1 Homo sapiens interleukin 21 (IL21), transcript variant 1, mRNA.

Price & Availability↑

CloneID	OHu26552
Clone ID Related Accession (Same CDS sequence)	NM_021803.4 , NM_021803.3
Accession Version	NM_021803.3	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 489bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2017-12-31
Organism	Homo sapiens(human)
Product	interleukin-21 isoform 1 precursor
Comment	Comment: REVIEWED REFSEQ: This record has been curated by NCBI staff. The reference sequence was derived from AF254069.1 and BC069124.1. This sequence is a reference standard in the RefSeqGene project. On Dec 23, 2011 this sequence version replaced NM_021803.2. Transcript Variant: This variant (1) encodes the longer isoform (1). Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: AF254069.1, CD559609.2 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA1965299, SAMEA1966682 [ECO:0000348] ##Evidence-Data-END##

ATGAGATCCA GTCCTGGCAA CATGGAGAGG ATTGTCATCT GTCTGATGGT CATCTTCTTG 
GGGACACTGG TCCACAAATC AAGCTCCCAA GGTCAAGATC GCCACATGAT TAGAATGCGT 
CAACTTATAG ATATTGTTGA TCAGCTGAAA AATTATGTGA ATGACTTGGT CCCTGAATTT 
CTGCCAGCTC CAGAAGATGT AGAGACAAAC TGTGAGTGGT CAGCTTTTTC CTGCTTTCAG 
AAGGCCCAAC TAAAGTCAGC AAATACAGGA AACAATGAAA GGATAATCAA TGTATCAATT 
AAAAAGCTGA AGAGGAAACC ACCTTCCACA AATGCAGGGA GAAGACAGAA ACACAGACTA 
ACATGCCCTT CATGTGATTC TTATGAGAAA AAACCACCCA AAGAATTCCT AGAAAGATTC 
AAATCACTTC TCCAAAAGAT GATTCATCAG CATCTGTCCT CTAGAACACA CGGAAGTGAA 
GATTCCTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_068575.1
CDS	47..535
Translation	MRSSPGNMERIVICLMVIFLGTLVHKSSSQGQDRHMIRMRQLIDIVDQLKNYVNDLVPEFLPAPEDVETNCEWSAFSCFQKAQLKSANTGNNERIINVSIKKLKRKPPSTNAGRRQKHRLTCPSCDSYEKKPPKEFLERFKSLLQKMIHQHLSSRTHGSEDS

Target ORF information:

RefSeq Version	NM_021803.3
Organism	Homo sapiens(human)
Definition	Homo sapiens interleukin 21 (IL21), transcript variant 1, mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_021803.3

ORF Insert Sequence:

ATGAGATCCA GTCCTGGCAA CATGGAGAGG ATTGTCATCT GTCTGATGGT CATCTTCTTG 
GGGACACTGG TCCACAAATC AAGCTCCCAA GGTCAAGATC GCCACATGAT TAGAATGCGT 
CAACTTATAG ATATTGTTGA TCAGCTGAAA AATTATGTGA ATGACTTGGT CCCTGAATTT 
CTGCCAGCTC CAGAAGATGT AGAGACAAAC TGTGAGTGGT CAGCTTTTTC CTGCTTTCAG 
AAGGCCCAAC TAAAGTCAGC AAATACAGGA AACAATGAAA GGATAATCAA TGTATCAATT 
AAAAAGCTGA AGAGGAAACC ACCTTCCACA AATGCAGGGA GAAGACAGAA ACACAGACTA 
ACATGCCCTT CATGTGATTC TTATGAGAAA AAACCACCCA AAGAATTCCT AGAAAGATTC 
AAATCACTTC TCCAAAAGAT GATTCATCAG CATCTGTCCT CTAGAACACA CGGAAGTGAA 
GATTCCTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

PubMed

IL-21 Is Increased in Nasal Polyposis and after Stimulation with Staphylococcus aureus Enterotoxin B.
International archives of allergy and immunology174(3-4)161-169(2017)
Calus L,Derycke L,Dullaers M,Van Zele T,De Ruyck N,P?rez-Novo C,Holtappels G,De Vos G,Lambrecht BN,Bachert C,Gevaert P

- Most Popular Services
  - 人工遺伝子合成& DNA合成-納期保証
- Services & Products

見積依頼

Eメール

japanmarket@genscript.com

電話

03-6811-6572

FAX

03-6811-6573
050-3174-7589(受注専用)

オンラインフォーム

オンライン注文

IL21 cDNA ORF clone, Homo sapiens(human)

Gene

Clones

gRNAs

Related articles in PubMed

Target ORF information:

Target ORF information:

ORF Insert Sequence:

Target ORF information:

Target ORF information:

ORF Insert Sequence:

Target ORF information:

Target ORF information:

ORF Insert Sequence:

Most Popular Services

Services & Products

見積依頼

Eメール

電話

FAX

オンラインフォーム

サポート

会社情報

サポート

会社情報