RAB6A cDNA ORF clone, Homo sapiens(human)

Gene
Clones
gRNAs

Summary

Gene Symbol	RAB6A
Entrez Gene ID	5870
Full Name	RAB6A, member RAS oncogene family
Synonyms	RAB6
General protein information	Preferred Names RAB6A, member RAS oncogene family Names ras-related protein Rab-6A RAB6, member RAS oncogene family Rab GTPase
Gene Type	protein-coding
Organism	Homo sapiens(human)
Genome	Chromosome: 11 Map Location: 11q13.4
Summary	This gene encodes a member of the RAB family, which belongs to the small GTPase superfamily. GTPases of the RAB family bind to various effectors to regulate the targeting and fusion of transport carriers to acceptor compartments. This protein is located at the Golgi apparatus, which regulates trafficking in both a retrograde (from early endosomes and Golgi to the endoplasmic reticulum) and an anterograde (from the Golgi to the plasma membrane) directions. Myosin II is an effector of this protein in these processes. This protein is also involved in assembly of human cytomegalovirus (HCMV) by interacting with the cellular protein Bicaudal D1, which interacts with the HCMV virion tegument protein, pp150. Multiple alternatively spliced transcript variants encoding different isoforms have been identified. [provided by RefSeq, Aug 2011].
Disorder MIM:	179513

mRNA and Protein(s)

mRNA	Protein	Name
NM_001243718.1	NP_001230647.1	ras-related protein Rab-6A isoform d
NM_001243718.2	NP_001230647.1	ras-related protein Rab-6A isoform d
NM_001243719.1	NP_001230648.1	ras-related protein Rab-6A isoform c
NM_198896.2	NP_942599.1	ras-related protein Rab-6A isoform b
NM_002869.4	NP_002860.2	ras-related protein Rab-6A isoform a
NM_198896.1	NP_942599.1	ras-related protein Rab-6A isoform b
NM_002869.5	NP_002860.2	ras-related protein Rab-6A isoform a

Pathways from BioSystems

Homologies

Caenorhabditis elegans (roundworm)	rab-6.1	NP_498993.1
Arabidopsis thaliana (thale cress)	RAB6A	NP_181989.1
Oryza sativa (rice)	Os07g0496000	NP_001059699.1
Pan troglodytes (chimpanzee)	RAB6A	XP_003313253.2
Mus musculus (house mouse)	Rab6a	NP_001157135.1
Gallus gallus (chicken)	RAB6A	NP_001038105.1
Xenopus tropicalis (tropical clawed frog)	LOC100124772	NP_001096221.1
Homo sapiens (human)	RAB6A	NP_002860.2
	RAB6A	XP_001115437.1
Rattus norvegicus (Norway rat)	Rab6a	NP_445818.1
Danio rerio (zebrafish)	zgc:63637	NP_998530.1

Gene Ontology
Bibliography

Related articles in PubMed

MiR-5100 increases the cisplatin resistance of the lung cancer stem cells by inhibiting the Rab6.
Yang L, Lin Z, Wang Y, Gao S, Li Q, Li C, Xu W, Chen J, Liu T, Song Z, Liu G
Molecular carcinogenesis(2017 Nov)

ARHGEF10 directs the localization of Rab8 to Rab6-positive executive vesicles.
Shibata S, Kawanai T, Hara T, Yamamoto A, Chaya T, Tokuhara Y, Tsuji C, Sakai M, Tachibana T, Inagaki S
Journal of cell science129(19)3620-3634(2016 10)

GORAB Missense Mutations Disrupt RAB6 and ARF5 Binding and Golgi Targeting.
Egerer J, Emmerich D, Fischer-Zirnsak B, Chan WL, Meierhofer D, Tuysuz B, Marschner K, Sauer S, Barr FA, Mundlos S, Kornak U
The Journal of investigative dermatology135(10)2368-2376(2015 Oct)

Reconstitution of the targeting of Rab6A to the Golgi apparatus in semi-intact HeLa cells: A role of BICD2 in stabilizing Rab6A on Golgi membranes and a concerted role of Rab6A/BICD2 interactions in Golgi-to-ER retrograde transport.
Matsuto M, Kano F, Murata M
Biochimica et biophysica acta1853(10 Pt A)2592-609(2015 Oct)

GeneRIFs: Gene References Into Functions What's a GeneRIF?

Ectopic expression of an N-terminal-truncated ARHGEF10 mutant led to the generation of large vesicle-like structures containing both Rab6 and Rab8.
Title: ARHGEF10 directs the localization of Rab8 to Rab6-positive executive vesicles.

GORAB missense mutation disrupt RAB6 protein binding in genetic skin diseases.
Title: GORAB Missense Mutations Disrupt RAB6 and ARF5 Binding and Golgi Targeting.

several analyses of vesicular transport demonstrated that Rab6A and BICD2 play crucial roles in Golgi tubule fusion with the endoplasmic reticulum (ER) in brefeldin A (BFA)-treated cells
Title: Reconstitution of the targeting of Rab6A to the Golgi apparatus in semi-intact HeLa cells: A role of BICD2 in stabilizing Rab6A on Golgi membranes and a concerted role of Rab6A/BICD2 interactions in Golgi-to-ER retrograde transport.

Data suggest that miR-5100 promotes tumor growth by facilitating the G1/S transition and targeting Rab6.
Title: miR-5100 promotes tumor growth in lung cancer by targeting Rab6.

Rab6A binding to KIF1C's motor domain represents an entirely new mode of regulation for a kinesin motor, and likely has important consequences for KIF1C's cellular functions.
Title: Rab6 regulation of the kinesin family KIF1C motor domain contributes to Golgi tethering.

The following RAB6A gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the RAB6A cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1⁺/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.

***CloneID	Accession No.	Definition	**Vector	*Turnaround time	Price (USD)
OHu00242	NM_001243719.1 Latest version!	Homo sapiens RAB6A, member RAS oncogene family (RAB6A), transcript variant 3, mRNA.	pcDNA3.1-C-(k)DYK or customized vector	in pcDNA3.1-C-(k)DYK	$49.50-$69.30 $99.00
OHu02707	NM_198896.2 Latest version!	Homo sapiens RAB6A, member RAS oncogene family (RAB6A), transcript variant 2, mRNA.	pcDNA3.1-C-(k)DYK or customized vector	in pcDNA3.1-C-(k)DYK	$49.50-$69.30 $99.00
OHu17943	NM_002869.5 Latest version!	Homo sapiens RAB6A, member RAS oncogene family (RAB6A), transcript variant 1, mRNA.	pcDNA3.1-C-(k)DYK or customized vector	in pcDNA3.1-C-(k)DYK	$49.50-$69.30 $99.00
OHu10476	NM_001243718.2 Latest version!	Homo sapiens RAB6A, member RAS oncogene family (RAB6A), transcript variant 4, mRNA.	pcDNA3.1-C-(k)DYK or customized vector	7-9	$69.30 $99.00
View Old Accession Versions >>
OHu10476	NM_001243718.1	Homo sapiens RAB6A, member RAS oncogene family (RAB6A), transcript variant 4, mRNA.	pcDNA3.1-C-(k)DYK or customized vector	7-9	$69.30 $99.00
OHu02707	NM_198896.1	Homo sapiens RAB6A, member RAS oncogene family (RAB6A), transcript variant 2, mRNA.	pcDNA3.1-C-(k)DYK or customized vector	in pcDNA3.1-C-(k)DYK	$49.50-$69.30 $99.00
OHu17943	NM_002869.4	Homo sapiens RAB6A, member RAS oncogene family (RAB6A), transcript variant 1, mRNA.	pcDNA3.1-C-(k)DYK or customized vector	in pcDNA3.1-C-(k)DYK	$49.50-$69.30 $99.00
Hide Old Accession Versions >>

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** GenScript guarantees 100% sequence accuracy of all synthetic DNA constructs we deliver, but we do not guarantee protein expression in your experimental system. Protein expression is influenced by many factors that may vary between experiments or laboratories. In addition, please pay attention to the signal peptide, propeptide and transit peptide in target ORF, which may affect the choice of vector (N/C terminal tag vector).

***One clone ID might be correlated to multiple accession numbers, which share the same CDS sequence.

Reference Sequences (Refseq)

RAB6A ( NM_001243719.1 ) cDNA ORF clone, Homo sapiens(human) -> NP_001230648.1 Homo sapiens RAB6A, member RAS oncogene family (RAB6A), transcript variant 3, mRNA.

Price & Availability↑

CloneID	OHu00242
Clone ID Related Accession (Same CDS sequence)	NM_001243719.1
Accession Version	NM_001243719.1 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 528bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-08-04
Organism	Homo sapiens(human)
Product	ras-related protein Rab-6A isoform c
Comment	Comment: REVIEWED REFSEQ: This record has been curated by NCBI staff. The reference sequence was derived from AK301534.1 and AP002993.3. Transcript Variant: This variant (3) has an alternate 5' exon, resulting in a downstream AUG start codon, compared to variant 1. The resulting isoform (c) is shorter at the N-terminus, compared to isoform a. Sequence Note: This RefSeq record was created from transcript and genomic sequence data to make the sequence consistent with the reference genome assembly. The genomic coordinates used for the transcript record were based on transcript alignments. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: AK301534.1, DC425568.1 [ECO:0000332] RNAseq introns :: mixed/partial sample support SAMEA1965299, SAMEA1966682 [ECO:0000350] ##Evidence-Data-END##

ATGTATGACA GTTTTGACAA CACCTATCAG GCAACAATTG GCATTGACTT TTTATCAAAA 
ACTATGTACT TGGAGGATCG AACAATCAGG CTTCAGCTGT GGGATACTGC GGGTCAGGAA 
CGTTTCCGTA GCCTCATTCC CAGTTACATC CGTGATTCTG CTGCAGCTGT AGTAGTTTAC 
GATATCACAA ATGTTAACTC ATTCCAGCAA ACTACAAAGT GGATTGATGA TGTCAGAACA 
GAAAGAGGAA GTGATGTTAT CATCATGCTA GTAGGAAATA AAACAGATCT TGCTGACAAG 
AGGCAAGTGT CAATTGAGGA GGGAGAGAGG AAAGCCAAAG AGCTGAATGT TATGTTTATT 
GAAACTAGTG CAAAAGCTGG ATACAATGTA AAGCAGCTCT TTCGACGTGT AGCAGCAGCT 
TTGCCGGGAA TGGAAAGCAC ACAGGACAGA AGCAGAGAAG ATATGATTGA CATAAAACTG 
GAAAAGCCTC AGGAGCAACC AGTCAGTGAA GGAGGCTGTT CCTGCTAA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_001230648.1
CDS	76..603
Translation	MYDSFDNTYQATIGIDFLSKTMYLEDRTIRLQLWDTAGQERFRSLIPSYIRDSAAAVVVYDITNVNSFQQTTKWIDDVRTERGSDVIIMLVGNKTDLADKRQVSIEEGERKAKELNVMFIETSAKAGYNVKQLFRRVAAALPGMESTQDRSREDMIDIKLEKPQEQPVSEGGCSC

Target ORF information:

RefSeq Version	NM_001243719.1
Organism	Homo sapiens(human)
Definition	Homo sapiens RAB6A, member RAS oncogene family (RAB6A), transcript variant 3, mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_001243719.1

ORF Insert Sequence:

ATGTATGACA GTTTTGACAA CACCTATCAG GCAACAATTG GCATTGACTT TTTATCAAAA 
ACTATGTACT TGGAGGATCG AACAATCAGG CTTCAGCTGT GGGATACTGC GGGTCAGGAA 
CGTTTCCGTA GCCTCATTCC CAGTTACATC CGTGATTCTG CTGCAGCTGT AGTAGTTTAC 
GATATCACAA ATGTTAACTC ATTCCAGCAA ACTACAAAGT GGATTGATGA TGTCAGAACA 
GAAAGAGGAA GTGATGTTAT CATCATGCTA GTAGGAAATA AAACAGATCT TGCTGACAAG 
AGGCAAGTGT CAATTGAGGA GGGAGAGAGG AAAGCCAAAG AGCTGAATGT TATGTTTATT 
GAAACTAGTG CAAAAGCTGG ATACAATGTA AAGCAGCTCT TTCGACGTGT AGCAGCAGCT 
TTGCCGGGAA TGGAAAGCAC ACAGGACAGA AGCAGAGAAG ATATGATTGA CATAAAACTG 
GAAAAGCCTC AGGAGCAACC AGTCAGTGAA GGAGGCTGTT CCTGCTAA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RAB6A ( NM_198896.2 ) cDNA ORF clone, Homo sapiens(human) -> NP_942599.1 Homo sapiens RAB6A, member RAS oncogene family (RAB6A), transcript variant 2, mRNA.

Price & Availability↑

CloneID	OHu02707
Clone ID Related Accession (Same CDS sequence)	NM_198896.2 , NM_198896.1
Accession Version	NM_198896.2 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 627bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2020-01-03
Organism	Homo sapiens(human)
Product	ras-related protein Rab-6A isoform b
Comment	Comment: REVIEWED REFSEQ: This record has been curated by NCBI staff. The reference sequence was derived from CB989138.1, BI552973.1, BQ422263.1, CB067721.1, BC003617.2 and BU685989.1. On Jun 2, 2019 this sequence version replaced NM_198896.1. Transcript Variant: This variant (2) has an alternate exon with the same size in the coding region, compared to variant 1. The resulting isoform (b, also known as RAB6A) is the same size but has three different aa in an internal segment, compared to isoform a. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: SRR1803617.184230.1, SRR1803616.265743.1 [ECO:0000332] RNAseq introns :: mixed/partial sample support SAMEA1965299, SAMEA1966682 [ECO:0000350] ##Evidence-Data-END## ##RefSeq-Attributes-START## RefSeq Select criteria :: based on conservation, expression, longest protein ##RefSeq-Attributes-END##

ATGTCCACGG GCGGAGACTT CGGGAATCCG CTGAGGAAAT TCAAGCTGGT GTTCCTGGGG 
GAGCAAAGCG TTGGAAAGAC ATCTTTGATC ACCAGATTCA TGTATGACAG TTTTGACAAC 
ACCTATCAGG CAACAATTGG CATTGACTTT TTATCAAAAA CTATGTACTT GGAGGATCGA 
ACAGTACGAT TGCAATTATG GGACACAGCA GGTCAAGAGC GGTTCAGGAG CTTGATTCCT 
AGCTACATTC GTGACTCCAC TGTGGCAGTT GTTGTTTATG ATATCACAAA TGTTAACTCA 
TTCCAGCAAA CTACAAAGTG GATTGATGAT GTCAGAACAG AAAGAGGAAG TGATGTTATC 
ATCATGCTAG TAGGAAATAA AACAGATCTT GCTGACAAGA GGCAAGTGTC AATTGAGGAG 
GGAGAGAGGA AAGCCAAAGA GCTGAATGTT ATGTTTATTG AAACTAGTGC AAAAGCTGGA 
TACAATGTAA AGCAGCTCTT TCGACGTGTA GCAGCAGCTT TGCCGGGAAT GGAAAGCACA 
CAGGACAGAA GCAGAGAAGA TATGATTGAC ATAAAACTGG AAAAGCCTCA GGAGCAACCA 
GTCAGTGAAG GAGGCTGTTC CTGCTAA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_942599.1
CDS	440..1066
Translation	MSTGGDFGNPLRKFKLVFLGEQSVGKTSLITRFMYDSFDNTYQATIGIDFLSKTMYLEDRTVRLQLWDTAGQERFRSLIPSYIRDSTVAVVVYDITNVNSFQQTTKWIDDVRTERGSDVIIMLVGNKTDLADKRQVSIEEGERKAKELNVMFIETSAKAGYNVKQLFRRVAAALPGMESTQDRSREDMIDIKLEKPQEQPVSEGGCSC

Target ORF information:

RefSeq Version	NM_198896.2
Organism	Homo sapiens(human)
Definition	Homo sapiens RAB6A, member RAS oncogene family (RAB6A), transcript variant 2, mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_198896.2

ORF Insert Sequence:

ATGTCCACGG GCGGAGACTT CGGGAATCCG CTGAGGAAAT TCAAGCTGGT GTTCCTGGGG 
GAGCAAAGCG TTGGAAAGAC ATCTTTGATC ACCAGATTCA TGTATGACAG TTTTGACAAC 
ACCTATCAGG CAACAATTGG CATTGACTTT TTATCAAAAA CTATGTACTT GGAGGATCGA 
ACAGTACGAT TGCAATTATG GGACACAGCA GGTCAAGAGC GGTTCAGGAG CTTGATTCCT 
AGCTACATTC GTGACTCCAC TGTGGCAGTT GTTGTTTATG ATATCACAAA TGTTAACTCA 
TTCCAGCAAA CTACAAAGTG GATTGATGAT GTCAGAACAG AAAGAGGAAG TGATGTTATC 
ATCATGCTAG TAGGAAATAA AACAGATCTT GCTGACAAGA GGCAAGTGTC AATTGAGGAG 
GGAGAGAGGA AAGCCAAAGA GCTGAATGTT ATGTTTATTG AAACTAGTGC AAAAGCTGGA 
TACAATGTAA AGCAGCTCTT TCGACGTGTA GCAGCAGCTT TGCCGGGAAT GGAAAGCACA 
CAGGACAGAA GCAGAGAAGA TATGATTGAC ATAAAACTGG AAAAGCCTCA GGAGCAACCA 
GTCAGTGAAG GAGGCTGTTC CTGCTAA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RAB6A ( NM_198896.1 ) cDNA ORF clone, Homo sapiens(human) -> NP_942599.1 Homo sapiens RAB6A, member RAS oncogene family (RAB6A), transcript variant 2, mRNA.

Price & Availability↑

CloneID	OHu02707
Clone ID Related Accession (Same CDS sequence)	NM_198896.2 , NM_198896.1
Accession Version	NM_198896.1	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 627bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-02-15
Organism	Homo sapiens(human)
Product	ras-related protein Rab-6A isoform b
Comment	Comment: REVIEWED REFSEQ: This record has been curated by NCBI staff. The reference sequence was derived from BI545554.1, CB989138.1, BI552973.1, BQ422263.1, CB067721.1, BC003617.2 and BU685989.1. Transcript Variant: This variant (2) has an alternate exon with the same size in the coding region, compared to variant 1. The resulting isoform (b, also known as RAB6A) is the same size but has three different aa in an internal segment, compared to isoform a. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: SRR1660809.42213.1, SRR1803613.283487.1 [ECO:0000332] RNAseq introns :: mixed/partial sample support SAMEA1965299, SAMEA1966682 [ECO:0000350] ##Evidence-Data-END##

ATGTCCACGG GCGGAGACTT CGGGAATCCG CTGAGGAAAT TCAAGCTGGT GTTCCTGGGG 
GAGCAAAGCG TTGGAAAGAC ATCTTTGATC ACCAGATTCA TGTATGACAG TTTTGACAAC 
ACCTATCAGG CAACAATTGG CATTGACTTT TTATCAAAAA CTATGTACTT GGAGGATCGA 
ACAGTACGAT TGCAATTATG GGACACAGCA GGTCAAGAGC GGTTCAGGAG CTTGATTCCT 
AGCTACATTC GTGACTCCAC TGTGGCAGTT GTTGTTTATG ATATCACAAA TGTTAACTCA 
TTCCAGCAAA CTACAAAGTG GATTGATGAT GTCAGAACAG AAAGAGGAAG TGATGTTATC 
ATCATGCTAG TAGGAAATAA AACAGATCTT GCTGACAAGA GGCAAGTGTC AATTGAGGAG 
GGAGAGAGGA AAGCCAAAGA GCTGAATGTT ATGTTTATTG AAACTAGTGC AAAAGCTGGA 
TACAATGTAA AGCAGCTCTT TCGACGTGTA GCAGCAGCTT TGCCGGGAAT GGAAAGCACA 
CAGGACAGAA GCAGAGAAGA TATGATTGAC ATAAAACTGG AAAAGCCTCA GGAGCAACCA 
GTCAGTGAAG GAGGCTGTTC CTGCTAA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_942599.1
CDS	522..1148
Translation	MSTGGDFGNPLRKFKLVFLGEQSVGKTSLITRFMYDSFDNTYQATIGIDFLSKTMYLEDRTVRLQLWDTAGQERFRSLIPSYIRDSTVAVVVYDITNVNSFQQTTKWIDDVRTERGSDVIIMLVGNKTDLADKRQVSIEEGERKAKELNVMFIETSAKAGYNVKQLFRRVAAALPGMESTQDRSREDMIDIKLEKPQEQPVSEGGCSC

Target ORF information:

RefSeq Version	NM_198896.1
Organism	Homo sapiens(human)
Definition	Homo sapiens RAB6A, member RAS oncogene family (RAB6A), transcript variant 2, mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_198896.1

ORF Insert Sequence:

ATGTCCACGG GCGGAGACTT CGGGAATCCG CTGAGGAAAT TCAAGCTGGT GTTCCTGGGG 
GAGCAAAGCG TTGGAAAGAC ATCTTTGATC ACCAGATTCA TGTATGACAG TTTTGACAAC 
ACCTATCAGG CAACAATTGG CATTGACTTT TTATCAAAAA CTATGTACTT GGAGGATCGA 
ACAGTACGAT TGCAATTATG GGACACAGCA GGTCAAGAGC GGTTCAGGAG CTTGATTCCT 
AGCTACATTC GTGACTCCAC TGTGGCAGTT GTTGTTTATG ATATCACAAA TGTTAACTCA 
TTCCAGCAAA CTACAAAGTG GATTGATGAT GTCAGAACAG AAAGAGGAAG TGATGTTATC 
ATCATGCTAG TAGGAAATAA AACAGATCTT GCTGACAAGA GGCAAGTGTC AATTGAGGAG 
GGAGAGAGGA AAGCCAAAGA GCTGAATGTT ATGTTTATTG AAACTAGTGC AAAAGCTGGA 
TACAATGTAA AGCAGCTCTT TCGACGTGTA GCAGCAGCTT TGCCGGGAAT GGAAAGCACA 
CAGGACAGAA GCAGAGAAGA TATGATTGAC ATAAAACTGG AAAAGCCTCA GGAGCAACCA 
GTCAGTGAAG GAGGCTGTTC CTGCTAA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RAB6A ( NM_002869.4 ) cDNA ORF clone, Homo sapiens(human) -> NP_002860.2 Homo sapiens RAB6A, member RAS oncogene family (RAB6A), transcript variant 1, mRNA.

Price & Availability↑

CloneID	OHu17943
Clone ID Related Accession (Same CDS sequence)	NM_002869.4 , NM_002869.5
Accession Version	NM_002869.4	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 627bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-02-15
Organism	Homo sapiens(human)
Product	ras-related protein Rab-6A isoform a
Comment	Comment: REVIEWED REFSEQ: This record has been curated by NCBI staff. The reference sequence was derived from BI545554.1, CB989138.1, BC003617.2, CB067721.1 and BU685989.1. This sequence is a reference standard in the RefSeqGene project. On Dec 4, 2003 this sequence version replaced NM_002869.3. Transcript Variant: This variant (1) encodes isoform a, also known as RAB6A' or RAB6C. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: SRR1660807.155035.1, SRR1660809.183212.1 [ECO:0000332] RNAseq introns :: mixed/partial sample support SAMEA1965299, SAMEA1966682 [ECO:0000350] ##Evidence-Data-END##

ATGTCCACGG GCGGAGACTT CGGGAATCCG CTGAGGAAAT TCAAGCTGGT GTTCCTGGGG 
GAGCAAAGCG TTGGAAAGAC ATCTTTGATC ACCAGATTCA TGTATGACAG TTTTGACAAC 
ACCTATCAGG CAACAATTGG CATTGACTTT TTATCAAAAA CTATGTACTT GGAGGATCGA 
ACAATCAGGC TTCAGCTGTG GGATACTGCG GGTCAGGAAC GTTTCCGTAG CCTCATTCCC 
AGTTACATCC GTGATTCTGC TGCAGCTGTA GTAGTTTACG ATATCACAAA TGTTAACTCA 
TTCCAGCAAA CTACAAAGTG GATTGATGAT GTCAGAACAG AAAGAGGAAG TGATGTTATC 
ATCATGCTAG TAGGAAATAA AACAGATCTT GCTGACAAGA GGCAAGTGTC AATTGAGGAG 
GGAGAGAGGA AAGCCAAAGA GCTGAATGTT ATGTTTATTG AAACTAGTGC AAAAGCTGGA 
TACAATGTAA AGCAGCTCTT TCGACGTGTA GCAGCAGCTT TGCCGGGAAT GGAAAGCACA 
CAGGACAGAA GCAGAGAAGA TATGATTGAC ATAAAACTGG AAAAGCCTCA GGAGCAACCA 
GTCAGTGAAG GAGGCTGTTC CTGCTAA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_002860.2
CDS	522..1148
Translation	MSTGGDFGNPLRKFKLVFLGEQSVGKTSLITRFMYDSFDNTYQATIGIDFLSKTMYLEDRTIRLQLWDTAGQERFRSLIPSYIRDSAAAVVVYDITNVNSFQQTTKWIDDVRTERGSDVIIMLVGNKTDLADKRQVSIEEGERKAKELNVMFIETSAKAGYNVKQLFRRVAAALPGMESTQDRSREDMIDIKLEKPQEQPVSEGGCSC

Target ORF information:

RefSeq Version	NM_002869.4
Organism	Homo sapiens(human)
Definition	Homo sapiens RAB6A, member RAS oncogene family (RAB6A), transcript variant 1, mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_002869.4

ORF Insert Sequence:

ATGTCCACGG GCGGAGACTT CGGGAATCCG CTGAGGAAAT TCAAGCTGGT GTTCCTGGGG 
GAGCAAAGCG TTGGAAAGAC ATCTTTGATC ACCAGATTCA TGTATGACAG TTTTGACAAC 
ACCTATCAGG CAACAATTGG CATTGACTTT TTATCAAAAA CTATGTACTT GGAGGATCGA 
ACAATCAGGC TTCAGCTGTG GGATACTGCG GGTCAGGAAC GTTTCCGTAG CCTCATTCCC 
AGTTACATCC GTGATTCTGC TGCAGCTGTA GTAGTTTACG ATATCACAAA TGTTAACTCA 
TTCCAGCAAA CTACAAAGTG GATTGATGAT GTCAGAACAG AAAGAGGAAG TGATGTTATC 
ATCATGCTAG TAGGAAATAA AACAGATCTT GCTGACAAGA GGCAAGTGTC AATTGAGGAG 
GGAGAGAGGA AAGCCAAAGA GCTGAATGTT ATGTTTATTG AAACTAGTGC AAAAGCTGGA 
TACAATGTAA AGCAGCTCTT TCGACGTGTA GCAGCAGCTT TGCCGGGAAT GGAAAGCACA 
CAGGACAGAA GCAGAGAAGA TATGATTGAC ATAAAACTGG AAAAGCCTCA GGAGCAACCA 
GTCAGTGAAG GAGGCTGTTC CTGCTAA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RAB6A ( NM_002869.5 ) cDNA ORF clone, Homo sapiens(human) -> NP_002860.2 Homo sapiens RAB6A, member RAS oncogene family (RAB6A), transcript variant 1, mRNA.

Price & Availability↑

CloneID	OHu17943
Clone ID Related Accession (Same CDS sequence)	NM_002869.4 , NM_002869.5
Accession Version	NM_002869.5 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 627bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2020-01-03
Organism	Homo sapiens(human)
Product	ras-related protein Rab-6A isoform a
Comment	Comment: REVIEWED REFSEQ: This record has been curated by NCBI staff. The reference sequence was derived from CB989138.1, BC003617.2, CB067721.1 and BU685989.1. This sequence is a reference standard in the RefSeqGene project. On Jun 2, 2019 this sequence version replaced NM_002869.4. Transcript Variant: This variant (1) encodes isoform a, also known as RAB6A' or RAB6C. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: SRR1660805.140416.1, SRR1660805.229333.1 [ECO:0000332] RNAseq introns :: mixed/partial sample support SAMEA1965299, SAMEA1966682 [ECO:0000350] ##Evidence-Data-END##

ATGTCCACGG GCGGAGACTT CGGGAATCCG CTGAGGAAAT TCAAGCTGGT GTTCCTGGGG 
GAGCAAAGCG TTGGAAAGAC ATCTTTGATC ACCAGATTCA TGTATGACAG TTTTGACAAC 
ACCTATCAGG CAACAATTGG CATTGACTTT TTATCAAAAA CTATGTACTT GGAGGATCGA 
ACAATCAGGC TTCAGCTGTG GGATACTGCG GGTCAGGAAC GTTTCCGTAG CCTCATTCCC 
AGTTACATCC GTGATTCTGC TGCAGCTGTA GTAGTTTACG ATATCACAAA TGTTAACTCA 
TTCCAGCAAA CTACAAAGTG GATTGATGAT GTCAGAACAG AAAGAGGAAG TGATGTTATC 
ATCATGCTAG TAGGAAATAA AACAGATCTT GCTGACAAGA GGCAAGTGTC AATTGAGGAG 
GGAGAGAGGA AAGCCAAAGA GCTGAATGTT ATGTTTATTG AAACTAGTGC AAAAGCTGGA 
TACAATGTAA AGCAGCTCTT TCGACGTGTA GCAGCAGCTT TGCCGGGAAT GGAAAGCACA 
CAGGACAGAA GCAGAGAAGA TATGATTGAC ATAAAACTGG AAAAGCCTCA GGAGCAACCA 
GTCAGTGAAG GAGGCTGTTC CTGCTAA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_002860.2
CDS	440..1066
Translation	MSTGGDFGNPLRKFKLVFLGEQSVGKTSLITRFMYDSFDNTYQATIGIDFLSKTMYLEDRTIRLQLWDTAGQERFRSLIPSYIRDSAAAVVVYDITNVNSFQQTTKWIDDVRTERGSDVIIMLVGNKTDLADKRQVSIEEGERKAKELNVMFIETSAKAGYNVKQLFRRVAAALPGMESTQDRSREDMIDIKLEKPQEQPVSEGGCSC

Target ORF information:

RefSeq Version	NM_002869.5
Organism	Homo sapiens(human)
Definition	Homo sapiens RAB6A, member RAS oncogene family (RAB6A), transcript variant 1, mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_002869.5

ORF Insert Sequence:

ATGTCCACGG GCGGAGACTT CGGGAATCCG CTGAGGAAAT TCAAGCTGGT GTTCCTGGGG 
GAGCAAAGCG TTGGAAAGAC ATCTTTGATC ACCAGATTCA TGTATGACAG TTTTGACAAC 
ACCTATCAGG CAACAATTGG CATTGACTTT TTATCAAAAA CTATGTACTT GGAGGATCGA 
ACAATCAGGC TTCAGCTGTG GGATACTGCG GGTCAGGAAC GTTTCCGTAG CCTCATTCCC 
AGTTACATCC GTGATTCTGC TGCAGCTGTA GTAGTTTACG ATATCACAAA TGTTAACTCA 
TTCCAGCAAA CTACAAAGTG GATTGATGAT GTCAGAACAG AAAGAGGAAG TGATGTTATC 
ATCATGCTAG TAGGAAATAA AACAGATCTT GCTGACAAGA GGCAAGTGTC AATTGAGGAG 
GGAGAGAGGA AAGCCAAAGA GCTGAATGTT ATGTTTATTG AAACTAGTGC AAAAGCTGGA 
TACAATGTAA AGCAGCTCTT TCGACGTGTA GCAGCAGCTT TGCCGGGAAT GGAAAGCACA 
CAGGACAGAA GCAGAGAAGA TATGATTGAC ATAAAACTGG AAAAGCCTCA GGAGCAACCA 
GTCAGTGAAG GAGGCTGTTC CTGCTAA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RAB6A ( NM_001243718.1 ) cDNA ORF clone, Homo sapiens(human) -> NP_001230647.1 Homo sapiens RAB6A, member RAS oncogene family (RAB6A), transcript variant 4, mRNA.

Price & Availability↑

CloneID	OHu10476
Clone ID Related Accession (Same CDS sequence)	NM_001243718.1 , NM_001243718.2
Accession Version	NM_001243718.1	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 315bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-02-22
Organism	Homo sapiens(human)
Product	ras-related protein Rab-6A isoform d
Comment	Comment: REVIEWED REFSEQ: This record has been curated by NCBI staff. The reference sequence was derived from BI545554.1, AK223551.1, DQ437503.1 and AP002993.3. Transcript Variant: This variant (4) lacks two consecutive exons in the coding region, and the reading frame is not affected, compared to variant 1. The resulting isoform (d) lacks an internal segment, compared to isoform a. Sequence Note: This RefSeq record was created from transcript and genomic sequence data to make the sequence consistent with the reference genome assembly. The genomic coordinates used for the transcript record were based on transcript alignments. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: SRR1660809.112572.1, SRR1660805.247431.1 [ECO:0000332] RNAseq introns :: mixed/partial sample support SAMEA1965299, SAMEA1966682 [ECO:0000350] ##Evidence-Data-END##

ATGTCCACGG GCGGAGACTT CGGGAATCCG CTGAGGAAAT TCAAGCTGGT GTTCCTGGGG 
GAGCAAAGCG TTGGAAAGAC ATCTTTGATC ACCAGATTCA TGTATGACAG TTTTGACAAC 
ACCTATCAGG CAACAATTGG CATTGACTTT TTATCAAAAA CTATGTACTT GGAGGATCGA 
ACACTCTTTC GACGTGTAGC AGCAGCTTTG CCGGGAATGG AAAGCACACA GGACAGAAGC 
AGAGAAGATA TGATTGACAT AAAACTGGAA AAGCCTCAGG AGCAACCAGT CAGTGAAGGA 
GGCTGTTCCT GCTAA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_001230647.1
CDS	522..836
Translation	MSTGGDFGNPLRKFKLVFLGEQSVGKTSLITRFMYDSFDNTYQATIGIDFLSKTMYLEDRTLFRRVAAALPGMESTQDRSREDMIDIKLEKPQEQPVSEGGCSC

Target ORF information:

RefSeq Version	NM_001243718.1
Organism	Homo sapiens(human)
Definition	Homo sapiens RAB6A, member RAS oncogene family (RAB6A), transcript variant 4, mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_001243718.1

ORF Insert Sequence:

ATGTCCACGG GCGGAGACTT CGGGAATCCG CTGAGGAAAT TCAAGCTGGT GTTCCTGGGG 
GAGCAAAGCG TTGGAAAGAC ATCTTTGATC ACCAGATTCA TGTATGACAG TTTTGACAAC 
ACCTATCAGG CAACAATTGG CATTGACTTT TTATCAAAAA CTATGTACTT GGAGGATCGA 
ACACTCTTTC GACGTGTAGC AGCAGCTTTG CCGGGAATGG AAAGCACACA GGACAGAAGC 
AGAGAAGATA TGATTGACAT AAAACTGGAA AAGCCTCAGG AGCAACCAGT CAGTGAAGGA 
GGCTGTTCCT GCTAA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RAB6A ( NM_001243718.2 ) cDNA ORF clone, Homo sapiens(human) -> NP_001230647.1 Homo sapiens RAB6A, member RAS oncogene family (RAB6A), transcript variant 4, mRNA.

Price & Availability↑

CloneID	OHu10476
Clone ID Related Accession (Same CDS sequence)	NM_001243718.1 , NM_001243718.2
Accession Version	NM_001243718.2 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 315bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2020-01-03
Organism	Homo sapiens(human)
Product	ras-related protein Rab-6A isoform d
Comment	Comment: REVIEWED REFSEQ: This record has been curated by NCBI staff. The reference sequence was derived from BI545554.1, AK223551.1, DQ437503.1 and AP002993.3. On Jun 2, 2019 this sequence version replaced NM_001243718.1. Transcript Variant: This variant (4) lacks two consecutive exons in the coding region, and the reading frame is not affected, compared to variant 1. The resulting isoform (d) lacks an internal segment, compared to isoform a. Sequence Note: This RefSeq record was created from transcript and genomic sequence data to make the sequence consistent with the reference genome assembly. The genomic coordinates used for the transcript record were based on transcript alignments. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: SRR1803616.222998.1, SRR1660805.247431.1 [ECO:0000332] RNAseq introns :: mixed/partial sample support SAMEA1965299, SAMEA1966682 [ECO:0000350] ##Evidence-Data-END##

ATGTCCACGG GCGGAGACTT CGGGAATCCG CTGAGGAAAT TCAAGCTGGT GTTCCTGGGG 
GAGCAAAGCG TTGGAAAGAC ATCTTTGATC ACCAGATTCA TGTATGACAG TTTTGACAAC 
ACCTATCAGG CAACAATTGG CATTGACTTT TTATCAAAAA CTATGTACTT GGAGGATCGA 
ACACTCTTTC GACGTGTAGC AGCAGCTTTG CCGGGAATGG AAAGCACACA GGACAGAAGC 
AGAGAAGATA TGATTGACAT AAAACTGGAA AAGCCTCAGG AGCAACCAGT CAGTGAAGGA 
GGCTGTTCCT GCTAA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_001230647.1
CDS	440..754
Translation	MSTGGDFGNPLRKFKLVFLGEQSVGKTSLITRFMYDSFDNTYQATIGIDFLSKTMYLEDRTLFRRVAAALPGMESTQDRSREDMIDIKLEKPQEQPVSEGGCSC

Target ORF information:

RefSeq Version	NM_001243718.2
Organism	Homo sapiens(human)
Definition	Homo sapiens RAB6A, member RAS oncogene family (RAB6A), transcript variant 4, mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_001243718.2

ORF Insert Sequence:

ATGTCCACGG GCGGAGACTT CGGGAATCCG CTGAGGAAAT TCAAGCTGGT GTTCCTGGGG 
GAGCAAAGCG TTGGAAAGAC ATCTTTGATC ACCAGATTCA TGTATGACAG TTTTGACAAC 
ACCTATCAGG CAACAATTGG CATTGACTTT TTATCAAAAA CTATGTACTT GGAGGATCGA 
ACACTCTTTC GACGTGTAGC AGCAGCTTTG CCGGGAATGG AAAGCACACA GGACAGAAGC 
AGAGAAGATA TGATTGACAT AAAACTGGAA AAGCCTCAGG AGCAACCAGT CAGTGAAGGA 
GGCTGTTCCT GCTAA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

PubMed

MiR-5100 increases the cisplatin resistance of the lung cancer stem cells by inhibiting the Rab6.
Molecular carcinogenesis(2017 Nov)
Yang L,Lin Z,Wang Y,Gao S,Li Q,Li C,Xu W,Chen J,Liu T,Song Z,Liu G

ARHGEF10 directs the localization of Rab8 to Rab6-positive executive vesicles.
Journal of cell science129(19)3620-3634(2016 10)
Shibata S,Kawanai T,Hara T,Yamamoto A,Chaya T,Tokuhara Y,Tsuji C,Sakai M,Tachibana T,Inagaki S

GORAB Missense Mutations Disrupt RAB6 and ARF5 Binding and Golgi Targeting.
The Journal of investigative dermatology135(10)2368-2376(2015 Oct)
Egerer J,Emmerich D,Fischer-Zirnsak B,Chan WL,Meierhofer D,Tuysuz B,Marschner K,Sauer S,Barr FA,Mundlos S,Kornak U

Reconstitution of the targeting of Rab6A to the Golgi apparatus in semi-intact HeLa cells: A role of BICD2 in stabilizing Rab6A on Golgi membranes and a concerted role of Rab6A/BICD2 interactions in Golgi-to-ER retrograde transport.
Biochimica et biophysica acta1853(10 Pt A)2592-609(2015 Oct)
Matsuto M,Kano F,Murata M

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RAB6A cDNA ORF clone, Homo sapiens(human)

Gene

Clones

gRNAs

Related articles in PubMed

Target ORF information:

Target ORF information:

ORF Insert Sequence:

Target ORF information:

Target ORF information:

ORF Insert Sequence:

Target ORF information:

Target ORF information:

ORF Insert Sequence:

Target ORF information:

Target ORF information:

ORF Insert Sequence:

Target ORF information:

Target ORF information:

ORF Insert Sequence:

Target ORF information:

Target ORF information:

ORF Insert Sequence:

Target ORF information:

Target ORF information:

ORF Insert Sequence:

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