PTS cDNA ORF clone, Homo sapiens(human)

Gene
Clones
gRNAs

Summary

Gene Symbol	PTS
Entrez Gene ID	5805
Full Name	6-pyruvoyltetrahydropterin synthase
Synonyms	PTPS
General protein information	Preferred Names 6-pyruvoyltetrahydropterin synthase Names 6-pyruvoyl tetrahydrobiopterin synthase PTP synthase
Gene Type	protein-coding
Organism	Homo sapiens(human)
Genome	Chromosome: 11 Map Location: 11q23.1
Summary	The enzyme encoded by this gene catalyzes the elimination of inorganic triphosphate from dihydroneopterin triphosphate, which is the second and irreversible step in the biosynthesis of tetrahydrobiopterin from GTP. Tetrahydrobiopterin, also known as BH(4), is an essential cofactor and regulator of various enzyme activities, including enzymes involved in serotonin biosynthesis and NO synthase activity. Mutations in this gene result in hyperphenylalaninemia. [provided by RefSeq, Oct 2008].
Disorder MIM:	612719
Disorder Html:	Hyperphenylalaninemia, BH4-deficient, A, 261640 (3)

mRNA and Protein(s)

mRNA	Protein	Name
NM_000317.3	NP_000308.1	6-pyruvoyl tetrahydrobiopterin synthase
NM_000317.2	NP_000308.1	6-pyruvoyl tetrahydrobiopterin synthase

Pathways from BioSystems

Homologies

Canis lupus familiaris (dog)	PTS	XP_854076.1
Rattus norvegicus (Norway rat)	Pts	NP_058916.1
Gallus gallus (chicken)	PTS	XP_004948194.1
Drosophila melanogaster (fruit fly)	pr	NP_724244.1
Xenopus tropicalis (tropical clawed frog)	LOC100487259	XP_002937697.1
Pan troglodytes (chimpanzee)	PTS	XP_001147929.1
	PTS	XP_001108264.1
Mus musculus (house mouse)	Pts	NP_035350.1
Bos taurus (cattle)	PTS	NP_001107009.1
Caenorhabditis elegans (roundworm)	ptps-1	NP_001040626.1
Danio rerio (zebrafish)	pts	NP_001092237.1
Homo sapiens (human)	PTS	NP_000308.1
Anopheles gambiae (African malaria mosquito)	AgaP_AGAP008730	XP_314842.3

Gene Ontology
Bibliography

Related articles in PubMed

An inter-species protein-protein interaction network across vast evolutionary distance.
Zhong Q, Pevzner SJ, Hao T, Wang Y, Mosca R, Menche J, Taipale M, Ta?an M, Fan C, Yang X, Haley P, Murray RR, Mer F, Gebreab F, Tam S, MacWilliams A, Dricot A, Reichert P, Santhanam B, Ghamsari L, Calderwood MA, Rolland T, Charloteaux B, Lindquist S, Barab?si AL, Hill DE, Aloy P, Cusick ME, Xia Y, Roth FP, Vidal M
Molecular systems biology12(4)865(2016 Apr)

Widespread macromolecular interaction perturbations in human genetic disorders.
Sahni N, Yi S, Taipale M, Fuxman Bass JI, Coulombe-Huntington J, Yang F, Peng J, Weile J, Karras GI, Wang Y, Kov?cs IA, Kamburov A, Krykbaeva I, Lam MH, Tucker G, Khurana V, Sharma A, Liu YY, Yachie N, Zhong Q, Shen Y, Palagi A, San-Miguel A, Fan C, Balcha D, Dricot A, Jordan DM, Walsh JM, Shah AA, Yang X, Stoyanova AK, Leighton A, Calderwood MA, Jacob Y, Cusick ME, Salehi-Ashtiani K, Whitesell LJ, Sunyaev S, Berger B, Barab?si AL, Charloteaux B, Hill DE, Hao T, Roth FP, Xia Y, Walhout AJM, Lindquist S, Vidal M
Cell161(3)647-660(2015 Apr)

Mutation spectrum of and founder effects affecting the PTS gene in East Asian populations.
Chiu YH, Chang YC, Chang YH, Niu DM, Yang YL, Ye J, Jiang J, Okano Y, Lee DH, Pangkanon S, Kuptanon C, Hock NL, Chiong MA, Cavan BV, Hsiao KJ, Liu TT
Journal of human genetics57(2)145-52(2012 Feb)

Next-generation sequencing to generate interactome datasets.
Yu H, Tardivo L, Tam S, Weiner E, Gebreab F, Fan C, Svrzikapa N, Hirozane-Kishikawa T, Rietman E, Yang X, Sahalie J, Salehi-Ashtiani K, Hao T, Cusick ME, Hill DE, Roth FP, Braun P, Vidal M
Nature methods8(6)478-80(2011 Jun)

Tetrahydrobiopterin biosynthesis, regeneration and functions.
Th?ny B, Auerbach G, Blau N
The Biochemical journal347 Pt 11-16(2000 Apr)

GeneRIFs: Gene References Into Functions What's a GeneRIF?

A total of 43 mutations were identified in the PTS gene in a screen of East Asian populations, comprising 22 previously reported mutations and 21 new discovered mutations.
Title: Mutation spectrum of and founder effects affecting the PTS gene in East Asian populations.

Observational study of gene-disease association. (HuGE Navigator)
Title: Genetic variants in nuclear-encoded mitochondrial genes influence AIDS progression.

Severe neurological impairment from BH4 deficiency could be prevented by newborn screening for hyperphenylalaninemia (HPA) and proper metabolic management.
Title: Novel mutation affecting the pterin-binding site of PTS gene and review of PTS mutations in Thai patients with 6-pyruvoyltetrahydropterin synthase deficiency.

Observational study of gene-disease association and gene-gene interaction. (HuGE Navigator)
Title: Examination of tetrahydrobiopterin pathway genes in autism.

Observational study of gene-disease association, gene-environment interaction, and pharmacogenomic / toxicogenomic. (HuGE Navigator)
Title: Exhaustive analysis of BH4 and dopamine biosynthesis genes in patients with Dopa-responsive dystonia.

The following PTS gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the PTS cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1⁺/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.

***CloneID	Accession No.	Definition	**Vector	*Turnaround time	Price (USD)
OHu19651	NM_000317.3 Latest version!	Homo sapiens 6-pyruvoyltetrahydropterin synthase (PTS), mRNA.	pcDNA3.1-C-(k)DYK or customized vector	in pcDNA3.1-C-(k)DYK	$49.50-$69.30 $99.00
View Old Accession Versions >>
OHu19651	NM_000317.2	Homo sapiens 6-pyruvoyltetrahydropterin synthase (PTS), mRNA.	pcDNA3.1-C-(k)DYK or customized vector	in pcDNA3.1-C-(k)DYK	$49.50-$69.30 $99.00
Hide Old Accession Versions >>

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** You may select a custom vector to replace pcDNA3.1+/C-(K)DYK after clone is added to cart.

** GenScript guarantees 100% sequence accuracy of all synthetic DNA constructs we deliver, but we do not guarantee protein expression in your experimental system. Protein expression is influenced by many factors that may vary between experiments or laboratories. In addition, please pay attention to the signal peptide, propeptide and transit peptide in target ORF, which may affect the choice of vector (N/C terminal tag vector).

***One clone ID might be correlated to multiple accession numbers, which share the same CDS sequence.

Reference Sequences (Refseq)

PTS ( NM_000317.3 ) cDNA ORF clone, Homo sapiens(human) -> NP_000308.1 Homo sapiens 6-pyruvoyltetrahydropterin synthase (PTS), mRNA.

Price & Availability↑

CloneID	OHu19651
Clone ID Related Accession (Same CDS sequence)	NM_000317.3 , NM_000317.2
Accession Version	NM_000317.3 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 438bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-08-21
Organism	Homo sapiens(human)
Product	6-pyruvoyl tetrahydrobiopterin synthase
Comment	Comment: REVIEWED REFSEQ: This record has been curated by NCBI staff. The reference sequence was derived from BC009686.1, AP002884.5 and CF529329.1. This sequence is a reference standard in the RefSeqGene project. On Nov 23, 2018 this sequence version replaced NM_000317.2. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: BG505490.1, SRR5189652.109963.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA1965299, SAMEA1966682 [ECO:0000348] ##Evidence-Data-END## ##RefSeq-Attributes-START## MANE Ensembl match :: ENST00000280362.8/ ENSP00000280362.3 RefSeq Select criteria :: based on single protein-coding transcript ##RefSeq-Attributes-END## COMPLETENESS: full length.

ATGAGCACGG AAGGTGGTGG CCGTCGCTGC CAGGCACAAG TGTCCCGCCG CATCTCCTTC 
AGCGCGAGCC ACCGATTGTA CAGTAAATTT CTAAGTGATG AAGAAAACTT GAAACTGTTT 
GGGAAATGCA ACAATCCAAA TGGCCATGGG CACAATTATA AAGTTGTGGT GACAGTACAT 
GGAGAGATTG ACCCTGCTAC GGGAATGGTT ATGAATCTGG CTGATCTCAA AAAATATATG 
GAGGAGGCGA TTATGCAGCC CCTTGATCAT AAGAATCTGG ATATGGATGT GCCATACTTT 
GCAGATGTGG TGAGCACGAC TGAAAATGTA GCTGTTTATA TCTGGGACAA CCTCCAGAAA 
GTTCTTCCTG TAGGAGTTCT TTATAAAGTA AAAGTATACG AAACTGACAA TAATATTGTG 
GTTTATAAAG GAGAATAG

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_000308.1
CDS	17..454
Translation	MSTEGGGRRCQAQVSRRISFSASHRLYSKFLSDEENLKLFGKCNNPNGHGHNYKVVVTVHGEIDPATGMVMNLADLKKYMEEAIMQPLDHKNLDMDVPYFADVVSTTENVAVYIWDNLQKVLPVGVLYKVKVYETDNNIVVYKGE

Target ORF information:

RefSeq Version	NM_000317.3
Organism	Homo sapiens(human)
Definition	Homo sapiens 6-pyruvoyltetrahydropterin synthase (PTS), mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_000317.3

ORF Insert Sequence:

ATGAGCACGG AAGGTGGTGG CCGTCGCTGC CAGGCACAAG TGTCCCGCCG CATCTCCTTC 
AGCGCGAGCC ACCGATTGTA CAGTAAATTT CTAAGTGATG AAGAAAACTT GAAACTGTTT 
GGGAAATGCA ACAATCCAAA TGGCCATGGG CACAATTATA AAGTTGTGGT GACAGTACAT 
GGAGAGATTG ACCCTGCTAC GGGAATGGTT ATGAATCTGG CTGATCTCAA AAAATATATG 
GAGGAGGCGA TTATGCAGCC CCTTGATCAT AAGAATCTGG ATATGGATGT GCCATACTTT 
GCAGATGTGG TGAGCACGAC TGAAAATGTA GCTGTTTATA TCTGGGACAA CCTCCAGAAA 
GTTCTTCCTG TAGGAGTTCT TTATAAAGTA AAAGTATACG AAACTGACAA TAATATTGTG 
GTTTATAAAG GAGAATAG

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

PTS ( NM_000317.2 ) cDNA ORF clone, Homo sapiens(human) -> NP_000308.1 Homo sapiens 6-pyruvoyltetrahydropterin synthase (PTS), mRNA.

Price & Availability↑

CloneID	OHu19651
Clone ID Related Accession (Same CDS sequence)	NM_000317.3 , NM_000317.2
Accession Version	NM_000317.2	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 438bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2017-12-26
Organism	Homo sapiens(human)
Product	6-pyruvoyl tetrahydrobiopterin synthase
Comment	Comment: REVIEWED REFSEQ: This record has been curated by NCBI staff. The reference sequence was derived from AP002884.5, BC009686.1 and CF529329.1. This sequence is a reference standard in the RefSeqGene project. On Jan 12, 2008 this sequence version replaced NM_000317.1. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: BG505490.1, SRR1163657.479679.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA1965299, SAMEA1966682 [ECO:0000348] ##Evidence-Data-END## COMPLETENESS: complete on the 3' end.

ATGAGCACGG AAGGTGGTGG CCGTCGCTGC CAGGCACAAG TGTCCCGCCG CATCTCCTTC 
AGCGCGAGCC ACCGATTGTA CAGTAAATTT CTAAGTGATG AAGAAAACTT GAAACTGTTT 
GGGAAATGCA ACAATCCAAA TGGCCATGGG CACAATTATA AAGTTGTGGT GACAGTACAT 
GGAGAGATTG ACCCTGCTAC GGGAATGGTT ATGAATCTGG CTGATCTCAA AAAATATATG 
GAGGAGGCGA TTATGCAGCC CCTTGATCAT AAGAATCTGG ATATGGATGT GCCATACTTT 
GCAGATGTGG TGAGCACGAC TGAAAATGTA GCTGTTTATA TCTGGGACAA CCTCCAGAAA 
GTTCTTCCTG TAGGAGTTCT TTATAAAGTA AAAGTATACG AAACTGACAA TAATATTGTG 
GTTTATAAAG GAGAATAG

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_000308.1
CDS	80..517
Translation	MSTEGGGRRCQAQVSRRISFSASHRLYSKFLSDEENLKLFGKCNNPNGHGHNYKVVVTVHGEIDPATGMVMNLADLKKYMEEAIMQPLDHKNLDMDVPYFADVVSTTENVAVYIWDNLQKVLPVGVLYKVKVYETDNNIVVYKGE

Target ORF information:

RefSeq Version	NM_000317.2
Organism	Homo sapiens(human)
Definition	Homo sapiens 6-pyruvoyltetrahydropterin synthase (PTS), mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_000317.2

ORF Insert Sequence:

ATGAGCACGG AAGGTGGTGG CCGTCGCTGC CAGGCACAAG TGTCCCGCCG CATCTCCTTC 
AGCGCGAGCC ACCGATTGTA CAGTAAATTT CTAAGTGATG AAGAAAACTT GAAACTGTTT 
GGGAAATGCA ACAATCCAAA TGGCCATGGG CACAATTATA AAGTTGTGGT GACAGTACAT 
GGAGAGATTG ACCCTGCTAC GGGAATGGTT ATGAATCTGG CTGATCTCAA AAAATATATG 
GAGGAGGCGA TTATGCAGCC CCTTGATCAT AAGAATCTGG ATATGGATGT GCCATACTTT 
GCAGATGTGG TGAGCACGAC TGAAAATGTA GCTGTTTATA TCTGGGACAA CCTCCAGAAA 
GTTCTTCCTG TAGGAGTTCT TTATAAAGTA AAAGTATACG AAACTGACAA TAATATTGTG 
GTTTATAAAG GAGAATAG

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

PubMed

An inter-species protein-protein interaction network across vast evolutionary distance.
Molecular systems biology12(4)865(2016 Apr)
Zhong Q,Pevzner SJ,Hao T,Wang Y,Mosca R,Menche J,Taipale M,Ta?an M,Fan C,Yang X,Haley P,Murray RR,Mer F,Gebreab F,Tam S,MacWilliams A,Dricot A,Reichert P,Santhanam B,Ghamsari L,Calderwood MA,Rolland T,Charloteaux B,Lindquist S,Barab?si AL,Hill DE,Aloy P,Cusick ME,Xia Y,Roth FP,Vidal M

Widespread macromolecular interaction perturbations in human genetic disorders.
Cell161(3)647-660(2015 Apr)
Sahni N,Yi S,Taipale M,Fuxman Bass JI,Coulombe-Huntington J,Yang F,Peng J,Weile J,Karras GI,Wang Y,Kov?cs IA,Kamburov A,Krykbaeva I,Lam MH,Tucker G,Khurana V,Sharma A,Liu YY,Yachie N,Zhong Q,Shen Y,Palagi A,San-Miguel A,Fan C,Balcha D,Dricot A,Jordan DM,Walsh JM,Shah AA,Yang X,Stoyanova AK,Leighton A,Calderwood MA,Jacob Y,Cusick ME,Salehi-Ashtiani K,Whitesell LJ,Sunyaev S,Berger B,Barab?si AL,Charloteaux B,Hill DE,Hao T,Roth FP,Xia Y,Walhout AJM,Lindquist S,Vidal M

Mutation spectrum of and founder effects affecting the PTS gene in East Asian populations.
Journal of human genetics57(2)145-52(2012 Feb)
Chiu YH,Chang YC,Chang YH,Niu DM,Yang YL,Ye J,Jiang J,Okano Y,Lee DH,Pangkanon S,Kuptanon C,Hock NL,Chiong MA,Cavan BV,Hsiao KJ,Liu TT

Next-generation sequencing to generate interactome datasets.
Nature methods8(6)478-80(2011 Jun)
Yu H,Tardivo L,Tam S,Weiner E,Gebreab F,Fan C,Svrzikapa N,Hirozane-Kishikawa T,Rietman E,Yang X,Sahalie J,Salehi-Ashtiani K,Hao T,Cusick ME,Hill DE,Roth FP,Braun P,Vidal M

Tetrahydrobiopterin biosynthesis, regeneration and functions.
The Biochemical journal347 Pt 11-16(2000 Apr)
Th?ny B,Auerbach G,Blau N

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PTS cDNA ORF clone, Homo sapiens(human)

Gene

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gRNAs

Related articles in PubMed

Target ORF information:

Target ORF information:

ORF Insert Sequence:

Target ORF information:

Target ORF information:

ORF Insert Sequence:

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