RAB22A cDNA ORF clone, Homo sapiens(human)

Gene
Clones
gRNAs

Summary

Gene Symbol	RAB22A
Entrez Gene ID	57403
Full Name	RAB22A, member RAS oncogene family
General protein information	Preferred Names RAB22A, member RAS oncogene family Names ras-related protein Rab-22A GTP-binding protein RAB22A rab-22
Gene Type	protein-coding
Organism	Homo sapiens(human)
Genome	Chromosome: 20 Map Location: 20q13.32
Summary	The protein encoded by this gene is a member of the RAB family of small GTPases. The GTP-bound form of the encoded protein has been shown to interact with early-endosomal antigen 1, and may be involved in the trafficking of and interaction between endosomal compartments. [provided by RefSeq, Jul 2008].
Disorder MIM:	612966

mRNA and Protein(s)

mRNA	Protein	Name
NM_020673.2	NP_065724.1	ras-related protein Rab-22A
NM_020673.3	NP_065724.1	ras-related protein Rab-22A

Pathways from BioSystems

Homologies

Homo sapiens (human)	RAB22A	NP_065724.1
Canis lupus familiaris (dog)	RAB22A	NP_001003208.1
Pan troglodytes (chimpanzee)	RAB22A	XP_001135766.3
	RAB22A	XP_001087750.2
Bos taurus (cattle)	RAB22A	NP_001092635.1
Gallus gallus (chicken)	RAB22A	NP_001026038.1
Mus musculus (house mouse)	Rab22a	NP_077756.2
Rattus norvegicus (Norway rat)	Rab22a	NP_001102436.1
Danio rerio (zebrafish)	rab22a	NP_991282.2

Gene Ontology
Bibliography

Related articles in PubMed

Rab22a enhances CD147 recycling and is required for lung cancer cell migration and invasion.
Zhou Y, Wu B, Li JH, Nan G, Jiang JL, Chen ZN
Experimental cell research357(1)9-16(2017 08)

RAB22A overexpression promotes the tumor growth of melanoma.
Su F, Chen Y, Zhu S, Li F, Zhao S, Wu L, Chen X, Su J
Oncotarget7(44)71744-71753(2016 Nov)

The Rab3A-22A Chimera Prevents Sperm Exocytosis by Stabilizing Open Fusion Pores.
Quevedo MF, Lucchesi O, Bustos MA, Pocognoni CA, De la Iglesia PX, Tomes CN
The Journal of biological chemistry291(44)23101-23111(2016 10)

GeneRIFs: Gene References Into Functions What's a GeneRIF?

that Rab22a enhances recycling of CD147, which is required for lung cancer cell migration and invasion
Title: Rab22a enhances CD147 recycling and is required for lung cancer cell migration and invasion.

Rab3A-22A blocks exocytosis at a stage downstream intra-acrosomal calcium release.
Title: The Rab3A-22A Chimera Prevents Sperm Exocytosis by Stabilizing Open Fusion Pores.

the HOTAIR lncRNA positively regulated the protein expression of Rab22a through competition for miR-373 binding. the positive regulation between HOTAIR and Rab22a may be partially attributed to the ceRNA regulatory network via miR-373, indicating a potential therapeutic target for ovarian cancer.
Title: LncRNA HOTAIR controls the expression of Rab22a by sponging miR-373 in ovarian cancer.

RAB22A role in epithelial-mesenchymal transition of melanoma cells
Title: MiR-211 is epigenetically regulated by DNMT1 mediated methylation and inhibits EMT of melanoma cells by targeting RAB22A.

miR-204 suppressed renal cell carcinoma proliferation and invasion by directly targeting the RAB22A gene.
Title: MiR-204 inhibits the proliferation and invasion of renal cell carcinoma by inhibiting RAB22A expression.

The following RAB22A gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the RAB22A cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1⁺/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.

***CloneID	Accession No.	Definition	**Vector	*Turnaround time	Price (USD)
OHu11577	NM_020673.3 Latest version!	Homo sapiens RAB22A, member RAS oncogene family (RAB22A), mRNA.	pcDNA3.1-C-(k)DYK or customized vector	in pcDNA3.1-C-(k)DYK	$49.50-$69.30 $99.00
View Old Accession Versions >>
OHu11577	NM_020673.2	Homo sapiens RAB22A, member RAS oncogene family (RAB22A), mRNA.	pcDNA3.1-C-(k)DYK or customized vector	in pcDNA3.1-C-(k)DYK	$49.50-$69.30 $99.00
Hide Old Accession Versions >>

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** GenScript guarantees 100% sequence accuracy of all synthetic DNA constructs we deliver, but we do not guarantee protein expression in your experimental system. Protein expression is influenced by many factors that may vary between experiments or laboratories. In addition, please pay attention to the signal peptide, propeptide and transit peptide in target ORF, which may affect the choice of vector (N/C terminal tag vector).

***One clone ID might be correlated to multiple accession numbers, which share the same CDS sequence.

Reference Sequences (Refseq)

RAB22A ( NM_020673.2 ) cDNA ORF clone, Homo sapiens(human) -> NP_065724.1 Homo sapiens RAB22A, member RAS oncogene family (RAB22A), mRNA.

Price & Availability↑

CloneID	OHu11577
Clone ID Related Accession (Same CDS sequence)	NM_020673.2 , NM_020673.3
Accession Version	NM_020673.2	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 585bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2017-11-25
Organism	Homo sapiens(human)
Product	ras-related protein Rab-22A
Comment	Comment: REVIEWED REFSEQ: This record has been curated by NCBI staff. The reference sequence was derived from DB452461.1, BC015710.1, AL035455.30 and BC042545.1. On Sep 11, 2003 this sequence version replaced NM_020673.1. Sequence Note: This RefSeq record was created from transcript and genomic sequence data to make the sequence consistent with the reference genome assembly. The genomic coordinates used for the transcript record were based on transcript alignments. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: AK091180.1, AJ276210.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA1965299, SAMEA1966682 [ECO:0000348] ##Evidence-Data-END## COMPLETENESS: complete on the 3' end.

ATGGCGCTGA GGGAGCTCAA AGTGTGTCTG CTCGGGGATA CAGGTGTAGG TAAATCGAGT 
ATTGTGTGGC GGTTTGTGGA AGACAGTTTT GATCCAAACA TCAACCCAAC AATAGGGGCA 
TCTTTTATGA CCAAGACTGT CCAGTACCAA AATGAGCTAC ATAAATTCCT AATCTGGGAT 
ACAGCTGGAC AAGAACGATT TCGTGCCTTA GCACCAATGT ACTATCGAGG GTCGGCTGCA 
GCTATAATCG TTTATGATAT CACAAAAGAA GAGACATTTT CAACATTAAA GAATTGGGTG 
AAAGAGCTTC GACAGCATGG CCCACCTAAT ATTGTAGTTG CCATTGCAGG AAATAAATGT 
GATCTTATCG ATGTAAGAGA AGTCATGGAG AGAGATGCAA AGGACTACGC CGACTCTATT 
CATGCAATTT TTGTAGAGAC CAGCGCAAAA AACGCGATAA ACATAAATGA ACTCTTTATA 
GAAATTAGTC GAAGAATTCC ATCCACTGAC GCCAACCTGC CATCTGGCGG TAAGGGCTTC 
AAACTCCGAA GACAGCCTTC AGAGCCAAAG CGGAGCTGCT GCTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_065724.1
CDS	263..847
Translation	MALRELKVCLLGDTGVGKSSIVWRFVEDSFDPNINPTIGASFMTKTVQYQNELHKFLIWDTAGQERFRALAPMYYRGSAAAIIVYDITKEETFSTLKNWVKELRQHGPPNIVVAIAGNKCDLIDVREVMERDAKDYADSIHAIFVETSAKNAININELFIEISRRIPSTDANLPSGGKGFKLRRQPSEPKRSCC

Target ORF information:

RefSeq Version	NM_020673.2
Organism	Homo sapiens(human)
Definition	Homo sapiens RAB22A, member RAS oncogene family (RAB22A), mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_020673.2

ORF Insert Sequence:

ATGGCGCTGA GGGAGCTCAA AGTGTGTCTG CTCGGGGATA CAGGTGTAGG TAAATCGAGT 
ATTGTGTGGC GGTTTGTGGA AGACAGTTTT GATCCAAACA TCAACCCAAC AATAGGGGCA 
TCTTTTATGA CCAAGACTGT CCAGTACCAA AATGAGCTAC ATAAATTCCT AATCTGGGAT 
ACAGCTGGAC AAGAACGATT TCGTGCCTTA GCACCAATGT ACTATCGAGG GTCGGCTGCA 
GCTATAATCG TTTATGATAT CACAAAAGAA GAGACATTTT CAACATTAAA GAATTGGGTG 
AAAGAGCTTC GACAGCATGG CCCACCTAAT ATTGTAGTTG CCATTGCAGG AAATAAATGT 
GATCTTATCG ATGTAAGAGA AGTCATGGAG AGAGATGCAA AGGACTACGC CGACTCTATT 
CATGCAATTT TTGTAGAGAC CAGCGCAAAA AACGCGATAA ACATAAATGA ACTCTTTATA 
GAAATTAGTC GAAGAATTCC ATCCACTGAC GCCAACCTGC CATCTGGCGG TAAGGGCTTC 
AAACTCCGAA GACAGCCTTC AGAGCCAAAG CGGAGCTGCT GCTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RAB22A ( NM_020673.3 ) cDNA ORF clone, Homo sapiens(human) -> NP_065724.1 Homo sapiens RAB22A, member RAS oncogene family (RAB22A), mRNA.

Price & Availability↑

CloneID	OHu11577
Clone ID Related Accession (Same CDS sequence)	NM_020673.2 , NM_020673.3
Accession Version	NM_020673.3 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 585bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-07-22
Organism	Homo sapiens(human)
Product	ras-related protein Rab-22A
Comment	Comment: REVIEWED REFSEQ: This record has been curated by NCBI staff. The reference sequence was derived from DB452461.1, BC015710.1, AL035455.30 and BC042545.1. On Nov 22, 2018 this sequence version replaced NM_020673.2. Sequence Note: This RefSeq record was created from transcript and genomic sequence data to make the sequence consistent with the reference genome assembly. The genomic coordinates used for the transcript record were based on transcript alignments. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: AK091180.1, AJ276210.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA1965299, SAMEA1966682 [ECO:0000348] ##Evidence-Data-END## ##RefSeq-Attributes-START## MANE Ensembl match :: ENST00000244040.4/ ENSP00000244040.3 RefSeq Select criteria :: based on single protein-coding transcript ##RefSeq-Attributes-END## COMPLETENESS: full length.

ATGGCGCTGA GGGAGCTCAA AGTGTGTCTG CTCGGGGATA CAGGTGTAGG TAAATCGAGT 
ATTGTGTGGC GGTTTGTGGA AGACAGTTTT GATCCAAACA TCAACCCAAC AATAGGGGCA 
TCTTTTATGA CCAAGACTGT CCAGTACCAA AATGAGCTAC ATAAATTCCT AATCTGGGAT 
ACAGCTGGAC AAGAACGATT TCGTGCCTTA GCACCAATGT ACTATCGAGG GTCGGCTGCA 
GCTATAATCG TTTATGATAT CACAAAAGAA GAGACATTTT CAACATTAAA GAATTGGGTG 
AAAGAGCTTC GACAGCATGG CCCACCTAAT ATTGTAGTTG CCATTGCAGG AAATAAATGT 
GATCTTATCG ATGTAAGAGA AGTCATGGAG AGAGATGCAA AGGACTACGC CGACTCTATT 
CATGCAATTT TTGTAGAGAC CAGCGCAAAA AACGCGATAA ACATAAATGA ACTCTTTATA 
GAAATTAGTC GAAGAATTCC ATCCACTGAC GCCAACCTGC CATCTGGCGG TAAGGGCTTC 
AAACTCCGAA GACAGCCTTC AGAGCCAAAG CGGAGCTGCT GCTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_065724.1
CDS	263..847
Translation	MALRELKVCLLGDTGVGKSSIVWRFVEDSFDPNINPTIGASFMTKTVQYQNELHKFLIWDTAGQERFRALAPMYYRGSAAAIIVYDITKEETFSTLKNWVKELRQHGPPNIVVAIAGNKCDLIDVREVMERDAKDYADSIHAIFVETSAKNAININELFIEISRRIPSTDANLPSGGKGFKLRRQPSEPKRSCC

Target ORF information:

RefSeq Version	NM_020673.3
Organism	Homo sapiens(human)
Definition	Homo sapiens RAB22A, member RAS oncogene family (RAB22A), mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_020673.3

ORF Insert Sequence:

ATGGCGCTGA GGGAGCTCAA AGTGTGTCTG CTCGGGGATA CAGGTGTAGG TAAATCGAGT 
ATTGTGTGGC GGTTTGTGGA AGACAGTTTT GATCCAAACA TCAACCCAAC AATAGGGGCA 
TCTTTTATGA CCAAGACTGT CCAGTACCAA AATGAGCTAC ATAAATTCCT AATCTGGGAT 
ACAGCTGGAC AAGAACGATT TCGTGCCTTA GCACCAATGT ACTATCGAGG GTCGGCTGCA 
GCTATAATCG TTTATGATAT CACAAAAGAA GAGACATTTT CAACATTAAA GAATTGGGTG 
AAAGAGCTTC GACAGCATGG CCCACCTAAT ATTGTAGTTG CCATTGCAGG AAATAAATGT 
GATCTTATCG ATGTAAGAGA AGTCATGGAG AGAGATGCAA AGGACTACGC CGACTCTATT 
CATGCAATTT TTGTAGAGAC CAGCGCAAAA AACGCGATAA ACATAAATGA ACTCTTTATA 
GAAATTAGTC GAAGAATTCC ATCCACTGAC GCCAACCTGC CATCTGGCGG TAAGGGCTTC 
AAACTCCGAA GACAGCCTTC AGAGCCAAAG CGGAGCTGCT GCTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

PubMed

Rab22a enhances CD147 recycling and is required for lung cancer cell migration and invasion.
Experimental cell research357(1)9-16(2017 08)
Zhou Y,Wu B,Li JH,Nan G,Jiang JL,Chen ZN

RAB22A overexpression promotes the tumor growth of melanoma.
Oncotarget7(44)71744-71753(2016 Nov)
Su F,Chen Y,Zhu S,Li F,Zhao S,Wu L,Chen X,Su J

The Rab3A-22A Chimera Prevents Sperm Exocytosis by Stabilizing Open Fusion Pores.
The Journal of biological chemistry291(44)23101-23111(2016 10)
Quevedo MF,Lucchesi O,Bustos MA,Pocognoni CA,De la Iglesia PX,Tomes CN

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RAB22A cDNA ORF clone, Homo sapiens(human)

Gene

Clones

gRNAs

Related articles in PubMed

Target ORF information:

Target ORF information:

ORF Insert Sequence:

Target ORF information:

Target ORF information:

ORF Insert Sequence:

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