CLTRN cDNA ORF clone, Homo sapiens(human)

Gene
Clones
gRNAs

Summary

Gene Symbol	CLTRN
Entrez Gene ID	57393
Full Name	collectrin, amino acid transport regulator
Synonyms	NX-17,NX17,TMEM27
General protein information	Preferred Names collectrin, amino acid transport regulator Names collectrin kidney-specific membrane protein transmembrane protein 27
Gene Type	protein-coding
Organism	Homo sapiens(human)
Genome	Chromosome: X Map Location: Xp22.2
Summary	This gene encodes a type 1 transmembrane protein that is important for trafficking amino acid transporters to the apical brush border of proximal tubules. The encoded protein binds to amino acid transporters and regulates their expression on the plasma membrane. It also plays a role in controlling insulin exocytosis by regulating formation of the SNARE (soluble N-ethylmaleimide-sensitive-factor attachment protein receptor) complex in pancreatic beta cells. The extracellular domain of the encoded protein may be cleaved and shed from the plasma membrane specifically in pancreatic beta cells. [provided by RefSeq, Jun 2013].
Disorder MIM:	300631

mRNA and Protein(s)

mRNA	Protein	Name
XM_024452411.1	XP_024308179.1	collectrin isoform X1
NM_020665.6	NP_065716.1	collectrin precursor
XM_017029680.1	XP_016885169.1	collectrin isoform X1
NM_020665.5	NP_065716.1	collectrin precursor
XM_017029681.1	XP_016885170.1	collectrin isoform X2

Pathways from BioSystems

Homologies

Canis lupus familiaris (dog)	TMEM27	XP_854205.1
Bos taurus (cattle)	TMEM27	NP_001069071.1
Rattus norvegicus (Norway rat)	Tmem27	NP_066125.1
Xenopus tropicalis (tropical clawed frog)	tmem27	XP_002938294.2
Homo sapiens (human)	TMEM27	NP_065716.1
	TMEM27	XP_001101718.1
Gallus gallus (chicken)	TMEM27	XP_416821.4
Danio rerio (zebrafish)	si:dkey-194e6.1	NP_001132930.1
Mus musculus (house mouse)	Tmem27	NP_065651.1

Gene Ontology
Bibliography

Related articles in PubMed

Serum collectrin levels in patients with early- and late-onset preeclampsia.
Aslan Cetin B, Aydogan Mathyk B, Cift T, Tuten A, Bulut B, Yilmaz N, Erenel H, Ekmekci H, Gezer A
The journal of maternal-fetal & neonatal medicine : the official journal of the European Association of Perinatal Medicine, the Federation of Asia and Oceania Perinatal Societies, the International Society of Perinatal Obstetricians1-5(2017 Aug)

Lack of TMEM27 expression is associated with postoperative progression of clinically localized conventional renal cell carcinoma.
Javorhazy A, Farkas N, Beothe T, Pusztai C, Szanto A, Kovacs G
Journal of cancer research and clinical oncology142(9)1947-53(2016 Sep)

Tmem27 is upregulated by vitamin D in INS-1 cells and its serum concentrations are low in patients with autoimmune diabetes.
Pepaj M, Gjerlaugsen N, Julien K, Thorsby PM
Scandinavian journal of clinical and laboratory investigation74(4)358-65(2014 Jun)

Multimodal imaging of pancreatic beta cells in vivo by targeting transmembrane protein 27 (TMEM27).
Vats D, Wang H, Esterhazy D, Dikaiou K, Danzer C, Honer M, Stuker F, Matile H, Migliorini C, Fischer E, Ripoll J, Keist R, Krek W, Schibli R, Stoffel M, Rudin M
Diabetologia55(9)2407-16(2012 Sep)

Tmem27 dimerization, deglycosylation, plasma membrane depletion, and the extracellular Phe-Phe motif are negative regulators of cleavage by Bace2.
Esterh?zy D, Akpinar P, Stoffel M
Biological chemistry393(6)473-84(2012 May)

GeneRIFs: Gene References Into Functions What's a GeneRIF?

Lack of expression of the TMEM27 in conventional renal cell carcinoma defines a group of patients at high risk for cancer-related death.
Title: Lack of TMEM27 expression is associated with postoperative progression of clinically localized conventional renal cell carcinoma.

Tmem27 is present in human serum and its levels are significantly lower in subjects with autoimmune diabetes as compared to healthy individuals.
Title: Tmem27 is upregulated by vitamin D in INS-1 cells and its serum concentrations are low in patients with autoimmune diabetes.

Tmem27 dimerization is a dynamic process involving Bace2
Title: Tmem27 dimerization, deglycosylation, plasma membrane depletion, and the extracellular Phe-Phe motif are negative regulators of cleavage by Bace2.

Bace2 specifically targets Tmem27 and cleaves its extracellular domain, which is then shed from the plasma membrane of pancreatic beta cells.
Title: Bace2 is a ? cell-enriched protease that regulates pancreatic ? cell function and mass.

Collectrin and ACE2 in renal and intestinal amino acid transport.
Title: Collectrin and ACE2 in renal and intestinal amino acid transport.

The following CLTRN gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the CLTRN cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1⁺/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.

***CloneID	Accession No.	Definition	**Vector	*Turnaround time	Price (USD)
OHu20996	NM_020665.6 Latest version!	Homo sapiens collectrin, amino acid transport regulator (CLTRN), mRNA.	pcDNA3.1-C-(k)DYK or customized vector	in pcDNA3.1-C-(k)DYK	$49.50-$69.30 $99.00
OHu99399	XM_017029680.1 Latest version!	Homo sapiens collectrin, amino acid transport regulator (CLTRN), transcript variant X1, mRNA.	pcDNA3.1-C-(k)DYK or customized vector	7-9	$69.30 $99.00
OHu99399	XM_024452411.1 Latest version!	Homo sapiens collectrin, amino acid transport regulator (CLTRN), transcript variant X2, mRNA.	pcDNA3.1-C-(k)DYK or customized vector	7-9	$69.30 $99.00
OHu99400	XM_017029681.1 Latest version!	Homo sapiens collectrin, amino acid transport regulator (CLTRN), transcript variant X3, mRNA.	pcDNA3.1-C-(k)DYK or customized vector	9-11	$69.30 $99.00
View Old Accession Versions >>
OHu20996	NM_020665.5	Homo sapiens collectrin, amino acid transport regulator (CLTRN), mRNA.	pcDNA3.1-C-(k)DYK or customized vector	in pcDNA3.1-C-(k)DYK	$49.50-$69.30 $99.00
Hide Old Accession Versions >>

ORF Online Only Promotion

Next-day Shipping ORF Clones ( in default vector with tag)
1 Clone	30% OFF
2-4 Clone	40% OFF
5 or more Clone	50% OFF
All Other ORF Clones
30% OFF

*Business Day

** You may select a custom vector to replace pcDNA3.1+/C-(K)DYK after clone is added to cart.

** GenScript guarantees 100% sequence accuracy of all synthetic DNA constructs we deliver, but we do not guarantee protein expression in your experimental system. Protein expression is influenced by many factors that may vary between experiments or laboratories. In addition, please pay attention to the signal peptide, propeptide and transit peptide in target ORF, which may affect the choice of vector (N/C terminal tag vector).

***One clone ID might be correlated to multiple accession numbers, which share the same CDS sequence.

Reference Sequences (Refseq)

CLTRN ( NM_020665.6 ) cDNA ORF clone, Homo sapiens(human) -> NP_065716.1 Homo sapiens collectrin, amino acid transport regulator (CLTRN), mRNA.

Price & Availability↑

CloneID	OHu20996
Clone ID Related Accession (Same CDS sequence)	NM_020665.6 , NM_020665.5
Accession Version	NM_020665.6 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 669bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-08-21
Organism	Homo sapiens(human)
Product	collectrin precursor
Comment	Comment: REVIEWED REFSEQ: This record has been curated by NCBI staff. The reference sequence was derived from BC014317.1 and AI470468.1. This sequence is a reference standard in the RefSeqGene project. On Nov 23, 2018 this sequence version replaced NM_020665.5. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: BC015099.1, SRR5189664.78391.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA2159080 [ECO:0000348] ##Evidence-Data-END## ##RefSeq-Attributes-START## MANE Ensembl match :: ENST00000380342.4/ ENSP00000369699.3 RefSeq Select criteria :: based on conservation, expression, longest protein ##RefSeq-Attributes-END## COMPLETENESS: full length.

ATGTTGTGGC TGCTCTTTTT TCTGGTGACT GCCATTCATG CTGAACTCTG TCAACCAGGT 
GCAGAAAATG CTTTTAAAGT GAGACTTAGT ATCAGAACAG CTCTGGGAGA TAAAGCATAT 
GCCTGGGATA CCAATGAAGA ATACCTCTTC AAAGCGATGG TAGCTTTCTC CATGAGAAAA 
GTTCCCAACA GAGAAGCAAC AGAAATTTCC CATGTCCTAC TTTGCAATGT AACCCAGAGG 
GTATCATTCT GGTTTGTGGT TACAGACCCT TCAAAAAATC ACACCCTTCC TGCTGTTGAG 
GTGCAATCAG CCATAAGAAT GAACAAGAAC CGGATCAACA ATGCCTTCTT TCTAAATGAC 
CAAACTCTGG AATTTTTAAA AATCCCTTCC ACACTTGCAC CACCCATGGA CCCATCTGTG 
CCCATCTGGA TTATTATATT TGGTGTGATA TTTTGCATCA TCATAGTTGC AATTGCACTA 
CTGATTTTAT CAGGGATCTG GCAACGTAGA AGAAAGAACA AAGAACCATC TGAAGTGGAT 
GACGCTGAAG ATAAGTGTGA AAACATGATC ACAATTGAAA ATGGCATCCC CTCTGATCCC 
CTGGACATGA AGGGAGGGCA TATTAATGAT GCCTTCATGA CAGAGGATGA GAGGCTCACC 
CCTCTCTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_065716.1
CDS	31..699
Translation	MLWLLFFLVTAIHAELCQPGAENAFKVRLSIRTALGDKAYAWDTNEEYLFKAMVAFSMRKVPNREATEISHVLLCNVTQRVSFWFVVTDPSKNHTLPAVEVQSAIRMNKNRINNAFFLNDQTLEFLKIPSTLAPPMDPSVPIWIIIFGVIFCIIIVAIALLILSGIWQRRRKNKEPSEVDDAEDKCENMITIENGIPSDPLDMKGGHINDAFMTEDERLTPL

Target ORF information:

RefSeq Version	NM_020665.6
Organism	Homo sapiens(human)
Definition	Homo sapiens collectrin, amino acid transport regulator (CLTRN), mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_020665.6

ORF Insert Sequence:

ATGTTGTGGC TGCTCTTTTT TCTGGTGACT GCCATTCATG CTGAACTCTG TCAACCAGGT 
GCAGAAAATG CTTTTAAAGT GAGACTTAGT ATCAGAACAG CTCTGGGAGA TAAAGCATAT 
GCCTGGGATA CCAATGAAGA ATACCTCTTC AAAGCGATGG TAGCTTTCTC CATGAGAAAA 
GTTCCCAACA GAGAAGCAAC AGAAATTTCC CATGTCCTAC TTTGCAATGT AACCCAGAGG 
GTATCATTCT GGTTTGTGGT TACAGACCCT TCAAAAAATC ACACCCTTCC TGCTGTTGAG 
GTGCAATCAG CCATAAGAAT GAACAAGAAC CGGATCAACA ATGCCTTCTT TCTAAATGAC 
CAAACTCTGG AATTTTTAAA AATCCCTTCC ACACTTGCAC CACCCATGGA CCCATCTGTG 
CCCATCTGGA TTATTATATT TGGTGTGATA TTTTGCATCA TCATAGTTGC AATTGCACTA 
CTGATTTTAT CAGGGATCTG GCAACGTAGA AGAAAGAACA AAGAACCATC TGAAGTGGAT 
GACGCTGAAG ATAAGTGTGA AAACATGATC ACAATTGAAA ATGGCATCCC CTCTGATCCC 
CTGGACATGA AGGGAGGGCA TATTAATGAT GCCTTCATGA CAGAGGATGA GAGGCTCACC 
CCTCTCTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

CLTRN ( NM_020665.5 ) cDNA ORF clone, Homo sapiens(human) -> NP_065716.1 Homo sapiens collectrin, amino acid transport regulator (CLTRN), mRNA.

Price & Availability↑

CloneID	OHu20996
Clone ID Related Accession (Same CDS sequence)	NM_020665.6 , NM_020665.5
Accession Version	NM_020665.5	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 669bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2017-12-12
Organism	Homo sapiens(human)
Product	collectrin precursor
Comment	Comment: REVIEWED REFSEQ: This record has been curated by NCBI staff. The reference sequence was derived from BC014317.1 and AI470468.1. This sequence is a reference standard in the RefSeqGene project. On Jun 27, 2013 this sequence version replaced NM_020665.4. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: BC014317.1, AF229179.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA2159080 [ECO:0000348] ##Evidence-Data-END## COMPLETENESS: complete on the 3' end.

ATGTTGTGGC TGCTCTTTTT TCTGGTGACT GCCATTCATG CTGAACTCTG TCAACCAGGT 
GCAGAAAATG CTTTTAAAGT GAGACTTAGT ATCAGAACAG CTCTGGGAGA TAAAGCATAT 
GCCTGGGATA CCAATGAAGA ATACCTCTTC AAAGCGATGG TAGCTTTCTC CATGAGAAAA 
GTTCCCAACA GAGAAGCAAC AGAAATTTCC CATGTCCTAC TTTGCAATGT AACCCAGAGG 
GTATCATTCT GGTTTGTGGT TACAGACCCT TCAAAAAATC ACACCCTTCC TGCTGTTGAG 
GTGCAATCAG CCATAAGAAT GAACAAGAAC CGGATCAACA ATGCCTTCTT TCTAAATGAC 
CAAACTCTGG AATTTTTAAA AATCCCTTCC ACACTTGCAC CACCCATGGA CCCATCTGTG 
CCCATCTGGA TTATTATATT TGGTGTGATA TTTTGCATCA TCATAGTTGC AATTGCACTA 
CTGATTTTAT CAGGGATCTG GCAACGTAGA AGAAAGAACA AAGAACCATC TGAAGTGGAT 
GACGCTGAAG ATAAGTGTGA AAACATGATC ACAATTGAAA ATGGCATCCC CTCTGATCCC 
CTGGACATGA AGGGAGGGCA TATTAATGAT GCCTTCATGA CAGAGGATGA GAGGCTCACC 
CCTCTCTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_065716.1
CDS	257..925
Translation	MLWLLFFLVTAIHAELCQPGAENAFKVRLSIRTALGDKAYAWDTNEEYLFKAMVAFSMRKVPNREATEISHVLLCNVTQRVSFWFVVTDPSKNHTLPAVEVQSAIRMNKNRINNAFFLNDQTLEFLKIPSTLAPPMDPSVPIWIIIFGVIFCIIIVAIALLILSGIWQRRRKNKEPSEVDDAEDKCENMITIENGIPSDPLDMKGGHINDAFMTEDERLTPL

Target ORF information:

RefSeq Version	NM_020665.5
Organism	Homo sapiens(human)
Definition	Homo sapiens collectrin, amino acid transport regulator (CLTRN), mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_020665.5

ORF Insert Sequence:

ATGTTGTGGC TGCTCTTTTT TCTGGTGACT GCCATTCATG CTGAACTCTG TCAACCAGGT 
GCAGAAAATG CTTTTAAAGT GAGACTTAGT ATCAGAACAG CTCTGGGAGA TAAAGCATAT 
GCCTGGGATA CCAATGAAGA ATACCTCTTC AAAGCGATGG TAGCTTTCTC CATGAGAAAA 
GTTCCCAACA GAGAAGCAAC AGAAATTTCC CATGTCCTAC TTTGCAATGT AACCCAGAGG 
GTATCATTCT GGTTTGTGGT TACAGACCCT TCAAAAAATC ACACCCTTCC TGCTGTTGAG 
GTGCAATCAG CCATAAGAAT GAACAAGAAC CGGATCAACA ATGCCTTCTT TCTAAATGAC 
CAAACTCTGG AATTTTTAAA AATCCCTTCC ACACTTGCAC CACCCATGGA CCCATCTGTG 
CCCATCTGGA TTATTATATT TGGTGTGATA TTTTGCATCA TCATAGTTGC AATTGCACTA 
CTGATTTTAT CAGGGATCTG GCAACGTAGA AGAAAGAACA AAGAACCATC TGAAGTGGAT 
GACGCTGAAG ATAAGTGTGA AAACATGATC ACAATTGAAA ATGGCATCCC CTCTGATCCC 
CTGGACATGA AGGGAGGGCA TATTAATGAT GCCTTCATGA CAGAGGATGA GAGGCTCACC 
CCTCTCTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

CLTRN ( XM_024452411.1 ) cDNA ORF clone, Homo sapiens(human) -> XP_024308179.1 Homo sapiens collectrin, amino acid transport regulator (CLTRN), transcript variant X2, mRNA.

Price & Availability↑

CloneID	OHu99399
Clone ID Related Accession (Same CDS sequence)	XM_024452411.1 , XM_017029680.1
Accession Version	XM_024452411.1 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 513bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-12-05
Organism	Homo sapiens(human)
Product	collectrin isoform X1
Comment	Comment: MODEL REFSEQ: This record is predicted by automated computational analysis. This record is derived from a genomic sequence (NC_000023.11) annotated using gene prediction method: Gnomon, supported by EST evidence. Also see: Documentation of NCBI's Annotation Process ##Genome-Annotation-Data-START## Annotation Provider :: NCBI Annotation Status :: Updated annotation Annotation Name :: Homo sapiens Updated Annotation Release 109.20191205 Annotation Version :: 109.20191205 Annotation Pipeline :: NCBI eukaryotic genome annotation pipeline Annotation Software Version :: 8.3 Annotation Method :: Best-placed RefSeq; propagated RefSeq model Features Annotated :: Gene; mRNA; CDS; ncRNA ##Genome-Annotation-Data-END##

ATGGTAGCTT TCTCCATGAG AAAAGTTCCC AACAGAGAAG CAACAGAAAT TTCCCATGTC 
CTACTTTGCA ATGTAACCCA GAGGGTATCA TTCTGGTTTG TGGTTACAGA CCCTTCAAAA 
AATCACACCC TTCCTGCTGT TGAGGTGCAA TCAGCCATAA GAATGAACAA GAACCGGATC 
AACAATGCCT TCTTTCTAAA TGACCAAACT CTGGAATTTT TAAAAATCCC TTCCACACTT 
GCACCACCCA TGGACCCATC TGTGCCCATC TGGATTATTA TATTTGGTGT GATATTTTGC 
ATCATCATAG TTGCAATTGC ACTACTGATT TTATCAGGGA TCTGGCAACG TAGAAGAAAG 
AACAAAGAAC CATCTGAAGT GGATGACGCT GAAGATAAGT GTGAAAACAT GATCACAATT 
GAAAATGGCA TCCCCTCTGA TCCCCTGGAC ATGAAGGGAG GGCATATTAA TGATGCCTTC 
ATGACAGAGG ATGAGAGGCT CACCCCTCTC TGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	XP_024308179.1
CDS	195..707
Translation	MVAFSMRKVPNREATEISHVLLCNVTQRVSFWFVVTDPSKNHTLPAVEVQSAIRMNKNRINNAFFLNDQTLEFLKIPSTLAPPMDPSVPIWIIIFGVIFCIIIVAIALLILSGIWQRRRKNKEPSEVDDAEDKCENMITIENGIPSDPLDMKGGHINDAFMTEDERLTPL

Target ORF information:

RefSeq Version	XM_024452411.1
Organism	Homo sapiens(human)
Definition	Homo sapiens collectrin, amino acid transport regulator (CLTRN), transcript variant X2, mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

XM_024452411.1

ORF Insert Sequence:

ATGGTAGCTT TCTCCATGAG AAAAGTTCCC AACAGAGAAG CAACAGAAAT TTCCCATGTC 
CTACTTTGCA ATGTAACCCA GAGGGTATCA TTCTGGTTTG TGGTTACAGA CCCTTCAAAA 
AATCACACCC TTCCTGCTGT TGAGGTGCAA TCAGCCATAA GAATGAACAA GAACCGGATC 
AACAATGCCT TCTTTCTAAA TGACCAAACT CTGGAATTTT TAAAAATCCC TTCCACACTT 
GCACCACCCA TGGACCCATC TGTGCCCATC TGGATTATTA TATTTGGTGT GATATTTTGC 
ATCATCATAG TTGCAATTGC ACTACTGATT TTATCAGGGA TCTGGCAACG TAGAAGAAAG 
AACAAAGAAC CATCTGAAGT GGATGACGCT GAAGATAAGT GTGAAAACAT GATCACAATT 
GAAAATGGCA TCCCCTCTGA TCCCCTGGAC ATGAAGGGAG GGCATATTAA TGATGCCTTC 
ATGACAGAGG ATGAGAGGCT CACCCCTCTC TGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

CLTRN ( XM_017029680.1 ) cDNA ORF clone, Homo sapiens(human) -> XP_016885169.1 Homo sapiens collectrin, amino acid transport regulator (CLTRN), transcript variant X1, mRNA.

Price & Availability↑

CloneID	OHu99399
Clone ID Related Accession (Same CDS sequence)	XM_024452411.1 , XM_017029680.1
Accession Version	XM_017029680.1 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 513bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-12-05
Organism	Homo sapiens(human)
Product	collectrin isoform X1
Comment	Comment: MODEL REFSEQ: This record is predicted by automated computational analysis. This record is derived from a genomic sequence (NC_000023.11) annotated using gene prediction method: Gnomon, supported by EST evidence. Also see: Documentation of NCBI's Annotation Process ##Genome-Annotation-Data-START## Annotation Provider :: NCBI Annotation Status :: Updated annotation Annotation Name :: Homo sapiens Updated Annotation Release 109.20191205 Annotation Version :: 109.20191205 Annotation Pipeline :: NCBI eukaryotic genome annotation pipeline Annotation Software Version :: 8.3 Annotation Method :: Best-placed RefSeq; propagated RefSeq model Features Annotated :: Gene; mRNA; CDS; ncRNA ##Genome-Annotation-Data-END##

ATGGTAGCTT TCTCCATGAG AAAAGTTCCC AACAGAGAAG CAACAGAAAT TTCCCATGTC 
CTACTTTGCA ATGTAACCCA GAGGGTATCA TTCTGGTTTG TGGTTACAGA CCCTTCAAAA 
AATCACACCC TTCCTGCTGT TGAGGTGCAA TCAGCCATAA GAATGAACAA GAACCGGATC 
AACAATGCCT TCTTTCTAAA TGACCAAACT CTGGAATTTT TAAAAATCCC TTCCACACTT 
GCACCACCCA TGGACCCATC TGTGCCCATC TGGATTATTA TATTTGGTGT GATATTTTGC 
ATCATCATAG TTGCAATTGC ACTACTGATT TTATCAGGGA TCTGGCAACG TAGAAGAAAG 
AACAAAGAAC CATCTGAAGT GGATGACGCT GAAGATAAGT GTGAAAACAT GATCACAATT 
GAAAATGGCA TCCCCTCTGA TCCCCTGGAC ATGAAGGGAG GGCATATTAA TGATGCCTTC 
ATGACAGAGG ATGAGAGGCT CACCCCTCTC TGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	XP_016885169.1
CDS	281..793
Translation	MVAFSMRKVPNREATEISHVLLCNVTQRVSFWFVVTDPSKNHTLPAVEVQSAIRMNKNRINNAFFLNDQTLEFLKIPSTLAPPMDPSVPIWIIIFGVIFCIIIVAIALLILSGIWQRRRKNKEPSEVDDAEDKCENMITIENGIPSDPLDMKGGHINDAFMTEDERLTPL

Target ORF information:

RefSeq Version	XM_017029680.1
Organism	Homo sapiens(human)
Definition	Homo sapiens collectrin, amino acid transport regulator (CLTRN), transcript variant X1, mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

XM_017029680.1

ORF Insert Sequence:

ATGGTAGCTT TCTCCATGAG AAAAGTTCCC AACAGAGAAG CAACAGAAAT TTCCCATGTC 
CTACTTTGCA ATGTAACCCA GAGGGTATCA TTCTGGTTTG TGGTTACAGA CCCTTCAAAA 
AATCACACCC TTCCTGCTGT TGAGGTGCAA TCAGCCATAA GAATGAACAA GAACCGGATC 
AACAATGCCT TCTTTCTAAA TGACCAAACT CTGGAATTTT TAAAAATCCC TTCCACACTT 
GCACCACCCA TGGACCCATC TGTGCCCATC TGGATTATTA TATTTGGTGT GATATTTTGC 
ATCATCATAG TTGCAATTGC ACTACTGATT TTATCAGGGA TCTGGCAACG TAGAAGAAAG 
AACAAAGAAC CATCTGAAGT GGATGACGCT GAAGATAAGT GTGAAAACAT GATCACAATT 
GAAAATGGCA TCCCCTCTGA TCCCCTGGAC ATGAAGGGAG GGCATATTAA TGATGCCTTC 
ATGACAGAGG ATGAGAGGCT CACCCCTCTC TGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

CLTRN ( XM_017029681.1 ) cDNA ORF clone, Homo sapiens(human) -> XP_016885170.1 Homo sapiens collectrin, amino acid transport regulator (CLTRN), transcript variant X3, mRNA.

Price & Availability↑

CloneID	OHu99400
Clone ID Related Accession (Same CDS sequence)	XM_017029681.1
Accession Version	XM_017029681.1 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 360bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-12-05
Organism	Homo sapiens(human)
Product	collectrin isoform X2
Comment	Comment: MODEL REFSEQ: This record is predicted by automated computational analysis. This record is derived from a genomic sequence (NC_000023.11) annotated using gene prediction method: Gnomon, supported by EST evidence. Also see: Documentation of NCBI's Annotation Process ##Genome-Annotation-Data-START## Annotation Provider :: NCBI Annotation Status :: Updated annotation Annotation Name :: Homo sapiens Updated Annotation Release 109.20191205 Annotation Version :: 109.20191205 Annotation Pipeline :: NCBI eukaryotic genome annotation pipeline Annotation Software Version :: 8.3 Annotation Method :: Best-placed RefSeq; propagated RefSeq model Features Annotated :: Gene; mRNA; CDS; ncRNA ##Genome-Annotation-Data-END##

ATGTTGTGGC TGCTCTTTTT TCTGGTGACT GCCATTCATG CTGAACTCTG TCAACCAGGT 
GCAGAAAATG CTTTTAAAGT GAGACTTAGT ATCAGAACAG CTCTGGGAGA TAAAGCATAT 
GCCTGGGATA CCAATGAAGA ATACCTCTTC AAAGCGATGG TAGCTTTCTC CATGAGAAAA 
GTTCCCAACA GAGAAGCAAC AGAAAAGAAC AAAGAACCAT CTGAAGTGGA TGACGCTGAA 
GATAAGTGTG AAAACATGAT CACAATTGAA AATGGCATCC CCTCTGATCC CCTGGACATG 
AAGGGAGGGC ATATTAATGA TGCCTTCATG ACAGAGGATG AGAGGCTCAC CCCTCTCTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	XP_016885170.1
CDS	532..891
Translation	MLWLLFFLVTAIHAELCQPGAENAFKVRLSIRTALGDKAYAWDTNEEYLFKAMVAFSMRKVPNREATEKNKEPSEVDDAEDKCENMITIENGIPSDPLDMKGGHINDAFMTEDERLTPL

Target ORF information:

RefSeq Version	XM_017029681.1
Organism	Homo sapiens(human)
Definition	Homo sapiens collectrin, amino acid transport regulator (CLTRN), transcript variant X3, mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

XM_017029681.1

ORF Insert Sequence:

ATGTTGTGGC TGCTCTTTTT TCTGGTGACT GCCATTCATG CTGAACTCTG TCAACCAGGT 
GCAGAAAATG CTTTTAAAGT GAGACTTAGT ATCAGAACAG CTCTGGGAGA TAAAGCATAT 
GCCTGGGATA CCAATGAAGA ATACCTCTTC AAAGCGATGG TAGCTTTCTC CATGAGAAAA 
GTTCCCAACA GAGAAGCAAC AGAAAAGAAC AAAGAACCAT CTGAAGTGGA TGACGCTGAA 
GATAAGTGTG AAAACATGAT CACAATTGAA AATGGCATCC CCTCTGATCC CCTGGACATG 
AAGGGAGGGC ATATTAATGA TGCCTTCATG ACAGAGGATG AGAGGCTCAC CCCTCTCTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

PubMed

Serum collectrin levels in patients with early- and late-onset preeclampsia.
The journal of maternal-fetal & neonatal medicine : the official journal of the European Association of Perinatal Medicine, the Federation of Asia and Oceania Perinatal Societies, the International Society of Perinatal Obstetricians1-5(2017 Aug)
Aslan Cetin B,Aydogan Mathyk B,Cift T,Tuten A,Bulut B,Yilmaz N,Erenel H,Ekmekci H,Gezer A

Lack of TMEM27 expression is associated with postoperative progression of clinically localized conventional renal cell carcinoma.
Journal of cancer research and clinical oncology142(9)1947-53(2016 Sep)
Javorhazy A,Farkas N,Beothe T,Pusztai C,Szanto A,Kovacs G

Tmem27 is upregulated by vitamin D in INS-1 cells and its serum concentrations are low in patients with autoimmune diabetes.
Scandinavian journal of clinical and laboratory investigation74(4)358-65(2014 Jun)
Pepaj M,Gjerlaugsen N,Julien K,Thorsby PM

Multimodal imaging of pancreatic beta cells in vivo by targeting transmembrane protein 27 (TMEM27).
Diabetologia55(9)2407-16(2012 Sep)
Vats D,Wang H,Esterhazy D,Dikaiou K,Danzer C,Honer M,Stuker F,Matile H,Migliorini C,Fischer E,Ripoll J,Keist R,Krek W,Schibli R,Stoffel M,Rudin M

Tmem27 dimerization, deglycosylation, plasma membrane depletion, and the extracellular Phe-Phe motif are negative regulators of cleavage by Bace2.
Biological chemistry393(6)473-84(2012 May)
Esterh?zy D,Akpinar P,Stoffel M

- Most Popular Services
  - 人工遺伝子合成& DNA合成-納期保証
- Services & Products

見積依頼

Eメール

japanmarket@genscript.com

電話

03-6811-6572

FAX

03-6811-6573
050-3174-7589(受注専用)

オンラインフォーム

オンライン注文

CLTRN cDNA ORF clone, Homo sapiens(human)

Gene

Clones

gRNAs

Related articles in PubMed

Target ORF information:

Target ORF information:

ORF Insert Sequence:

Target ORF information:

Target ORF information:

ORF Insert Sequence:

Target ORF information:

Target ORF information:

ORF Insert Sequence:

Target ORF information:

Target ORF information:

ORF Insert Sequence:

Target ORF information:

Target ORF information:

ORF Insert Sequence:

Most Popular Services

Services & Products

見積依頼

Eメール

電話

FAX

オンラインフォーム

サポート

会社情報

サポート

会社情報