PSMD3 cDNA ORF clone, Homo sapiens(human)

Gene
Clones
gRNAs

Summary

Gene Symbol	PSMD3
Entrez Gene ID	5709
Full Name	proteasome 26S subunit, non-ATPase 3
Synonyms	P58,RPN3,S3,TSTA2
General protein information	Preferred Names proteasome 26S subunit, non-ATPase 3 Names 26S proteasome non-ATPase regulatory subunit 3 26S proteasome regulatory subunit RPN3 26S proteasome regulatory subunit S3 proteasome (prosome, macropain) 26S subunit, non-ATPase, 3 proteasome subunit p58 tissue specific transplantation antigen 2
Gene Type	protein-coding
Organism	Homo sapiens(human)
Genome	Chromosome: 17 Map Location: 17q21.1
Summary	The 26S proteasome is a multicatalytic proteinase complex with a highly ordered structure composed of 2 complexes, a 20S core and a 19S regulator. The 20S core is composed of 4 rings of 28 non-identical subunits; 2 rings are composed of 7 alpha subunits and 2 rings are composed of 7 beta subunits. The 19S regulator is composed of a base, which contains 6 ATPase subunits and 2 non-ATPase subunits, and a lid, which contains up to 10 non-ATPase subunits. Proteasomes are distributed throughout eukaryotic cells at a high concentration and cleave peptides in an ATP/ubiquitin-dependent process in a non-lysosomal pathway. This gene encodes a member of the proteasome subunit S3 family that functions as one of the non-ATPase subunits of the 19S regulator lid. Single nucleotide polymorphisms in this gene are associated with neutrophil count. [provided by RefSeq, Jul 2012].
Disorder MIM:	617676

mRNA and Protein(s)

mRNA	Protein	Name
NM_002809.3	NP_002800.2	26S proteasome non-ATPase regulatory subunit 3
NM_002809.4	NP_002800.2	26S proteasome non-ATPase regulatory subunit 3

Pathways from BioSystems

Homologies

	PSMD3	XP_001094752.1
Bos taurus (cattle)	PSMD3	NP_001039365.1
Mus musculus (house mouse)	Psmd3	NP_033465.1
Rattus norvegicus (Norway rat)	Psmd3	NP_001008282.1
Eremothecium gossypii	AGOS_ABR164W	NP_983112.1
Neurospora crassa	NCU02224	XP_959637.1
Canis lupus familiaris (dog)	PSMD3	XP_548138.2
Anopheles gambiae (African malaria mosquito)	PSMD3_ANOGA	XP_319831.2
Schizosaccharomyces pombe (fission yeast)	rpn3	NP_595282.2
Oryza sativa (rice)	Os08g0550100	NP_001062444.1
Danio rerio (zebrafish)	psmd3	NP_956866.1
Saccharomyces cerevisiae (baker's yeast)	RPN3	NP_010938.1
Homo sapiens (human)	PSMD3	NP_002800.2
Pan troglodytes (chimpanzee)	PSMD3	NP_001233571.1
Drosophila melanogaster (fruit fly)	Rpn3	NP_477300.1
Caenorhabditis elegans (roundworm)	rpn-3	NP_498869.1
Kluyveromyces lactis	KLLA0D10824g	XP_453544.1
Arabidopsis thaliana (thale cress)	AT1G75990	NP_177726.1
Oryza sativa (rice)	Os09g0541900	NP_001063817.1
Gallus gallus (chicken)	PSMD3	NP_001026533.1
Magnaporthe oryzae (rice blast fungus)	MGG_00884	XP_003718082.1
Arabidopsis thaliana (thale cress)	EMB2719	NP_173447.1
Xenopus tropicalis (tropical clawed frog)	psmd3	XP_002940423.2

Gene Ontology
Bibliography

Related articles in PubMed

Mutations in proteasome-related genes are associated with thyroid hemiagenesis.
Budny B, Szczepanek-Parulska E, Zemojtel T, Szaflarski W, Rydzanicz M, Wesoly J, Handschuh L, Wolinski K, Piatek K, Niedziela M, Ziemnicka K, Figlerowicz M, Zabel M, Ruchala M
Endocrine56(2)279-285(2017 May)

Polymorphisms and haplotypes of the chromosome locus 17q12-17q21.1 contribute to adult asthma susceptibility in Slovenian patients.
?avbi M, Koro?ec P, Fle?ar M, ?krgat Kristan S, Marc Malovrh M, Rijavec M
Human immunology77(6)527-34(2016 Jun)

Widespread macromolecular interaction perturbations in human genetic disorders.
Sahni N, Yi S, Taipale M, Fuxman Bass JI, Coulombe-Huntington J, Yang F, Peng J, Weile J, Karras GI, Wang Y, Kov?cs IA, Kamburov A, Krykbaeva I, Lam MH, Tucker G, Khurana V, Sharma A, Liu YY, Yachie N, Zhong Q, Shen Y, Palagi A, San-Miguel A, Fan C, Balcha D, Dricot A, Jordan DM, Walsh JM, Shah AA, Yang X, Stoyanova AK, Leighton A, Calderwood MA, Jacob Y, Cusick ME, Salehi-Ashtiani K, Whitesell LJ, Sunyaev S, Berger B, Barab?si AL, Charloteaux B, Hill DE, Hao T, Roth FP, Xia Y, Walhout AJM, Lindquist S, Vidal M
Cell161(3)647-660(2015 Apr)

Phospho-tyrosine dependent protein-protein interaction network.
Grossmann A, Benlasfer N, Birth P, Hegele A, Wachsmuth F, Apelt L, Stelzl U
Molecular systems biology11(3)794(2015 Mar)

Identification of Novel Proteins Co-Purifying with Cockayne Syndrome Group B (CSB) Reveals Potential Roles for CSB in RNA Metabolism and Chromatin Dynamics.
Nicolai S, Filippi S, Caputo M, Cipak L, Gregan J, Ammerer G, Frontini M, Willems D, Prantera G, Balajee AS, Proietti-De-Santis L
PloS one10(6)e0128558(2015)

GeneRIFs: Gene References Into Functions What's a GeneRIF?

In thyroid hemiagenesis, genomic examinations revealed the presence of four recurrent defects (three deletions and one duplication) affecting highly conservative proteasome genes PSMA1, PSMA3, and PSMD3.
Title: Mutations in proteasome-related genes are associated with thyroid hemiagenesis.

this study shows that haplotypes consisting of single nucleotide polymorphisms harboring PSMD3, CSF3 and MED24 genes are associated with asthma in Slovenian patients
Title: Polymorphisms and haplotypes of the chromosome locus 17q12-17q21.1 contribute to adult asthma susceptibility in Slovenian patients.

A strong association between genetic variant rs2305482 in PSMD3 on chromosome 17 and IFN-induced neutropenia.
Title: Genome-wide association study identifies a PSMD3 variant associated with neutropenia in interferon-based therapy for chronic hepatitis C.

HNF1A gene was associated with C-reactive protein, and the region including PSMD3 and CSF3 genes was associated with white blood cell count.
Title: Genetic associations with C-reactive protein level and white blood cell count in the KARE study.

Our study suggests that PSMD3 variants are associated with insulin resistance in populations of different ancestries and that these relationships may also be modified by dietary factors.
Title: Genetic variants at PSMD3 interact with dietary fat and carbohydrate to modulate insulin resistance.

The following PSMD3 gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the PSMD3 cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1⁺/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.

***CloneID	Accession No.	Definition	**Vector	*Turnaround time	Price (USD)
OHu09589	NM_002809.4 Latest version!	Homo sapiens proteasome 26S subunit, non-ATPase 3 (PSMD3), mRNA.	pcDNA3.1-C-(k)DYK or customized vector	in pcDNA3.1-C-(k)DYK	$189.50-$265.30 $379.00
View Old Accession Versions >>
OHu09589	NM_002809.3	Homo sapiens proteasome 26S subunit, non-ATPase 3 (PSMD3), mRNA.	pcDNA3.1-C-(k)DYK or customized vector	in pcDNA3.1-C-(k)DYK	$189.50-$265.30 $379.00
Hide Old Accession Versions >>

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***One clone ID might be correlated to multiple accession numbers, which share the same CDS sequence.

Reference Sequences (Refseq)

PSMD3 ( NM_002809.3 ) cDNA ORF clone, Homo sapiens(human) -> NP_002800.2 Homo sapiens proteasome 26S subunit, non-ATPase 3 (PSMD3), mRNA.

Price & Availability↑

CloneID	OHu09589
Clone ID Related Accession (Same CDS sequence)	NM_002809.3 , NM_002809.4
Accession Version	NM_002809.3	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 1605bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2017-10-02
Organism	Homo sapiens(human)
Product	26S proteasome non-ATPase regulatory subunit 3
Comment	Comment: REVIEWED REFSEQ: This record has been curated by NCBI staff. The reference sequence was derived from HY034626.1, D67025.1 and AA143716.1. On Jul 11, 2012 this sequence version replaced NM_002809.2. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: BC012302.1, SRR1163658.110380.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA1965299, SAMEA1966682 [ECO:0000348] ##Evidence-Data-END## COMPLETENESS: complete on the 3' end.

ATGAAGCAGG AGGGCTCGGC GCGGCGCCGC GGCGCGGACA AGGCGAAACC GCCGCCCGGC 
GGAGGAGAAC AAGAACCCCC ACCGCCGCCG GCCCCCCAGG ATGTGGAGAT GAAAGAGGAG 
GCAGCGACGG GTGGCGGGTC GACGGGGGAG GCAGACGGCA AGACGGCGGC GGCAGCGGCT 
GAGCACTCCC AGCGAGAGCT GGACACAGTC ACCTTGGAGG ACATCAAGGA GCACGTGAAA 
CAGCTAGAGA AAGCGGTTTC AGGCAAGGAG CCGAGATTCG TGCTGCGGGC CCTGCGGATG 
CTGCCTTCCA CATCACGCCG CCTCAACCAC TATGTTCTGT ATAAGGCTGT GCAGGGCTTC 
TTCACTTCAA ATAATGCCAC TCGAGACTTT TTGCTCCCCT TCCTGGAAGA GCCCATGGAC 
ACAGAGGCTG ATTTACAGTT CCGTCCCCGC ACGGGAAAAG CTGCGTCGAC ACCCCTCCTG 
CCTGAAGTGG AAGCCTATCT CCAACTCCTC GTGGTCATCT TCATGATGAA CAGCAAGCGC 
TACAAAGAGG CACAGAAGAT CTCTGATGAT CTGATGCAGA AGATCAGTAC TCAGAACCGC 
CGGGCCCTAG ACCTTGTAGC CGCAAAGTGT TACTATTATC ACGCCCGGGT CTATGAGTTC 
CTGGACAAGC TGGATGTGGT GCGCAGCTTC TTGCATGCTC GGCTCCGGAC AGCTACGCTT 
CGGCATGACG CAGACGGGCA GGCCACCCTG TTGAACCTCC TGCTGCGGAA TTACCTACAC 
TACAGCTTGT ACGACCAGGC TGAGAAGCTG GTGTCCAAGT CTGTGTTCCC AGAGCAGGCC 
AACAACAATG AGTGGGCCAG GTACCTCTAC TACACAGGGC GAATCAAAGC CATCCAGCTG 
GAGTACTCAG AGGCCCGGAG AACGATGACC AACGCCCTTC GCAAGGCCCC TCAGCACACA 
GCTGTCGGCT TCAAACAGAC GGTGCACAAG CTTCTCATCG TGGTGGAGCT GTTGCTGGGG 
GAGATCCCTG ACCGGCTGCA GTTCCGCCAG CCCTCCCTCA AGCGCTCACT CATGCCCTAT 
TTCCTTCTGA CTCAAGCTGT CAGGACAGGA AACCTAGCCA AGTTCAACCA GGTCCTGGAT 
CAGTTTGGGG AGAAGTTTCA AGCAGATGGG ACCTACACCC TAATTATCCG GCTGCGGCAC 
AACGTGATTA AGACAGGTGT ACGCATGATC AGCCTCTCCT ATTCCCGAAT CTCCTTGGCT 
GACATCGCCC AGAAGCTGCA GTTGGATAGC CCCGAAGATG CAGAGTTCAT TGTTGCCAAG 
GCCATCCGGG ATGGTGTCAT TGAGGCCAGC ATCAACCACG AGAAGGGCTA TGTCCAATCC 
AAGGAGATGA TTGACATCTA TTCCACCCGA GAGCCCCAGC TAGCCTTCCA CCAGCGCATC 
TCCTTCTGCC TAGATATCCA CAACATGTCT GTCAAGGCCA TGAGGTTTCC TCCCAAATCG 
TACAACAAGG ACTTGGAGTC TGCAGAGGAA CGGCGTGAGC GAGAACAGCA GGACTTGGAG 
TTTGCCAAGG AGATGGCAGA AGATGATGAT GACAGCTTCC CTTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_002800.2
CDS	204..1808
Translation	MKQEGSARRRGADKAKPPPGGGEQEPPPPPAPQDVEMKEEAATGGGSTGEADGKTAAAAAEHSQRELDTVTLEDIKEHVKQLEKAVSGKEPRFVLRALRMLPSTSRRLNHYVLYKAVQGFFTSNNATRDFLLPFLEEPMDTEADLQFRPRTGKAASTPLLPEVEAYLQLLVVIFMMNSKRYKEAQKISDDLMQKISTQNRRALDLVAAKCYYYHARVYEFLDKLDVVRSFLHARLRTATLRHDADGQATLLNLLLRNYLHYSLYDQAEKLVSKSVFPEQANNNEWARYLYYTGRIKAIQLEYSEARRTMTNALRKAPQHTAVGFKQTVHKLLIVVELLLGEIPDRLQFRQPSLKRSLMPYFLLTQAVRTGNLAKFNQVLDQFGEKFQADGTYTLIIRLRHNVIKTGVRMISLSYSRISLADIAQKLQLDSPEDAEFIVAKAIRDGVIEASINHEKGYVQSKEMIDIYSTREPQLAFHQRISFCLDIHNMSVKAMRFPPKSYNKDLESAEERREREQQDLEFAKEMAEDDDDSFP

Target ORF information:

RefSeq Version	NM_002809.3
Organism	Homo sapiens(human)
Definition	Homo sapiens proteasome 26S subunit, non-ATPase 3 (PSMD3), mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_002809.3

ORF Insert Sequence:

ATGAAGCAGG AGGGCTCGGC GCGGCGCCGC GGCGCGGACA AGGCGAAACC GCCGCCCGGC 
GGAGGAGAAC AAGAACCCCC ACCGCCGCCG GCCCCCCAGG ATGTGGAGAT GAAAGAGGAG 
GCAGCGACGG GTGGCGGGTC GACGGGGGAG GCAGACGGCA AGACGGCGGC GGCAGCGGCT 
GAGCACTCCC AGCGAGAGCT GGACACAGTC ACCTTGGAGG ACATCAAGGA GCACGTGAAA 
CAGCTAGAGA AAGCGGTTTC AGGCAAGGAG CCGAGATTCG TGCTGCGGGC CCTGCGGATG 
CTGCCTTCCA CATCACGCCG CCTCAACCAC TATGTTCTGT ATAAGGCTGT GCAGGGCTTC 
TTCACTTCAA ATAATGCCAC TCGAGACTTT TTGCTCCCCT TCCTGGAAGA GCCCATGGAC 
ACAGAGGCTG ATTTACAGTT CCGTCCCCGC ACGGGAAAAG CTGCGTCGAC ACCCCTCCTG 
CCTGAAGTGG AAGCCTATCT CCAACTCCTC GTGGTCATCT TCATGATGAA CAGCAAGCGC 
TACAAAGAGG CACAGAAGAT CTCTGATGAT CTGATGCAGA AGATCAGTAC TCAGAACCGC 
CGGGCCCTAG ACCTTGTAGC CGCAAAGTGT TACTATTATC ACGCCCGGGT CTATGAGTTC 
CTGGACAAGC TGGATGTGGT GCGCAGCTTC TTGCATGCTC GGCTCCGGAC AGCTACGCTT 
CGGCATGACG CAGACGGGCA GGCCACCCTG TTGAACCTCC TGCTGCGGAA TTACCTACAC 
TACAGCTTGT ACGACCAGGC TGAGAAGCTG GTGTCCAAGT CTGTGTTCCC AGAGCAGGCC 
AACAACAATG AGTGGGCCAG GTACCTCTAC TACACAGGGC GAATCAAAGC CATCCAGCTG 
GAGTACTCAG AGGCCCGGAG AACGATGACC AACGCCCTTC GCAAGGCCCC TCAGCACACA 
GCTGTCGGCT TCAAACAGAC GGTGCACAAG CTTCTCATCG TGGTGGAGCT GTTGCTGGGG 
GAGATCCCTG ACCGGCTGCA GTTCCGCCAG CCCTCCCTCA AGCGCTCACT CATGCCCTAT 
TTCCTTCTGA CTCAAGCTGT CAGGACAGGA AACCTAGCCA AGTTCAACCA GGTCCTGGAT 
CAGTTTGGGG AGAAGTTTCA AGCAGATGGG ACCTACACCC TAATTATCCG GCTGCGGCAC 
AACGTGATTA AGACAGGTGT ACGCATGATC AGCCTCTCCT ATTCCCGAAT CTCCTTGGCT 
GACATCGCCC AGAAGCTGCA GTTGGATAGC CCCGAAGATG CAGAGTTCAT TGTTGCCAAG 
GCCATCCGGG ATGGTGTCAT TGAGGCCAGC ATCAACCACG AGAAGGGCTA TGTCCAATCC 
AAGGAGATGA TTGACATCTA TTCCACCCGA GAGCCCCAGC TAGCCTTCCA CCAGCGCATC 
TCCTTCTGCC TAGATATCCA CAACATGTCT GTCAAGGCCA TGAGGTTTCC TCCCAAATCG 
TACAACAAGG ACTTGGAGTC TGCAGAGGAA CGGCGTGAGC GAGAACAGCA GGACTTGGAG 
TTTGCCAAGG AGATGGCAGA AGATGATGAT GACAGCTTCC CTTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

PSMD3 ( NM_002809.4 ) cDNA ORF clone, Homo sapiens(human) -> NP_002800.2 Homo sapiens proteasome 26S subunit, non-ATPase 3 (PSMD3), mRNA.

Price & Availability↑

CloneID	OHu09589
Clone ID Related Accession (Same CDS sequence)	NM_002809.3 , NM_002809.4
Accession Version	NM_002809.4 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 1605bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-10-09
Organism	Homo sapiens(human)
Product	26S proteasome non-ATPase regulatory subunit 3
Comment	Comment: REVIEWED REFSEQ: This record has been curated by NCBI staff. The reference sequence was derived from HY034626.1, D67025.1 and AA143716.1. On Nov 22, 2018 this sequence version replaced NM_002809.3. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: AK054611.1, SRR3476690.333839.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA1965299, SAMEA1966682 [ECO:0000348] ##Evidence-Data-END## ##RefSeq-Attributes-START## MANE Ensembl match :: ENST00000264639.9/ ENSP00000264639.4 RefSeq Select criteria :: based on single protein-coding transcript ##RefSeq-Attributes-END## COMPLETENESS: full length.

ATGAAGCAGG AGGGCTCGGC GCGGCGCCGC GGCGCGGACA AGGCGAAACC GCCGCCCGGC 
GGAGGAGAAC AAGAACCCCC ACCGCCGCCG GCCCCCCAGG ATGTGGAGAT GAAAGAGGAG 
GCAGCGACGG GTGGCGGGTC GACGGGGGAG GCAGACGGCA AGACGGCGGC GGCAGCGGCT 
GAGCACTCCC AGCGAGAGCT GGACACAGTC ACCTTGGAGG ACATCAAGGA GCACGTGAAA 
CAGCTAGAGA AAGCGGTTTC AGGCAAGGAG CCGAGATTCG TGCTGCGGGC CCTGCGGATG 
CTGCCTTCCA CATCACGCCG CCTCAACCAC TATGTTCTGT ATAAGGCTGT GCAGGGCTTC 
TTCACTTCAA ATAATGCCAC TCGAGACTTT TTGCTCCCCT TCCTGGAAGA GCCCATGGAC 
ACAGAGGCTG ATTTACAGTT CCGTCCCCGC ACGGGAAAAG CTGCGTCGAC ACCCCTCCTG 
CCTGAAGTGG AAGCCTATCT CCAACTCCTC GTGGTCATCT TCATGATGAA CAGCAAGCGC 
TACAAAGAGG CACAGAAGAT CTCTGATGAT CTGATGCAGA AGATCAGTAC TCAGAACCGC 
CGGGCCCTAG ACCTTGTAGC CGCAAAGTGT TACTATTATC ACGCCCGGGT CTATGAGTTC 
CTGGACAAGC TGGATGTGGT GCGCAGCTTC TTGCATGCTC GGCTCCGGAC AGCTACGCTT 
CGGCATGACG CAGACGGGCA GGCCACCCTG TTGAACCTCC TGCTGCGGAA TTACCTACAC 
TACAGCTTGT ACGACCAGGC TGAGAAGCTG GTGTCCAAGT CTGTGTTCCC AGAGCAGGCC 
AACAACAATG AGTGGGCCAG GTACCTCTAC TACACAGGGC GAATCAAAGC CATCCAGCTG 
GAGTACTCAG AGGCCCGGAG AACGATGACC AACGCCCTTC GCAAGGCCCC TCAGCACACA 
GCTGTCGGCT TCAAACAGAC GGTGCACAAG CTTCTCATCG TGGTGGAGCT GTTGCTGGGG 
GAGATCCCTG ACCGGCTGCA GTTCCGCCAG CCCTCCCTCA AGCGCTCACT CATGCCCTAT 
TTCCTTCTGA CTCAAGCTGT CAGGACAGGA AACCTAGCCA AGTTCAACCA GGTCCTGGAT 
CAGTTTGGGG AGAAGTTTCA AGCAGATGGG ACCTACACCC TAATTATCCG GCTGCGGCAC 
AACGTGATTA AGACAGGTGT ACGCATGATC AGCCTCTCCT ATTCCCGAAT CTCCTTGGCT 
GACATCGCCC AGAAGCTGCA GTTGGATAGC CCCGAAGATG CAGAGTTCAT TGTTGCCAAG 
GCCATCCGGG ATGGTGTCAT TGAGGCCAGC ATCAACCACG AGAAGGGCTA TGTCCAATCC 
AAGGAGATGA TTGACATCTA TTCCACCCGA GAGCCCCAGC TAGCCTTCCA CCAGCGCATC 
TCCTTCTGCC TAGATATCCA CAACATGTCT GTCAAGGCCA TGAGGTTTCC TCCCAAATCG 
TACAACAAGG ACTTGGAGTC TGCAGAGGAA CGGCGTGAGC GAGAACAGCA GGACTTGGAG 
TTTGCCAAGG AGATGGCAGA AGATGATGAT GACAGCTTCC CTTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_002800.2
CDS	165..1769
Translation	MKQEGSARRRGADKAKPPPGGGEQEPPPPPAPQDVEMKEEAATGGGSTGEADGKTAAAAAEHSQRELDTVTLEDIKEHVKQLEKAVSGKEPRFVLRALRMLPSTSRRLNHYVLYKAVQGFFTSNNATRDFLLPFLEEPMDTEADLQFRPRTGKAASTPLLPEVEAYLQLLVVIFMMNSKRYKEAQKISDDLMQKISTQNRRALDLVAAKCYYYHARVYEFLDKLDVVRSFLHARLRTATLRHDADGQATLLNLLLRNYLHYSLYDQAEKLVSKSVFPEQANNNEWARYLYYTGRIKAIQLEYSEARRTMTNALRKAPQHTAVGFKQTVHKLLIVVELLLGEIPDRLQFRQPSLKRSLMPYFLLTQAVRTGNLAKFNQVLDQFGEKFQADGTYTLIIRLRHNVIKTGVRMISLSYSRISLADIAQKLQLDSPEDAEFIVAKAIRDGVIEASINHEKGYVQSKEMIDIYSTREPQLAFHQRISFCLDIHNMSVKAMRFPPKSYNKDLESAEERREREQQDLEFAKEMAEDDDDSFP

Target ORF information:

RefSeq Version	NM_002809.4
Organism	Homo sapiens(human)
Definition	Homo sapiens proteasome 26S subunit, non-ATPase 3 (PSMD3), mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_002809.4

ORF Insert Sequence:

ATGAAGCAGG AGGGCTCGGC GCGGCGCCGC GGCGCGGACA AGGCGAAACC GCCGCCCGGC 
GGAGGAGAAC AAGAACCCCC ACCGCCGCCG GCCCCCCAGG ATGTGGAGAT GAAAGAGGAG 
GCAGCGACGG GTGGCGGGTC GACGGGGGAG GCAGACGGCA AGACGGCGGC GGCAGCGGCT 
GAGCACTCCC AGCGAGAGCT GGACACAGTC ACCTTGGAGG ACATCAAGGA GCACGTGAAA 
CAGCTAGAGA AAGCGGTTTC AGGCAAGGAG CCGAGATTCG TGCTGCGGGC CCTGCGGATG 
CTGCCTTCCA CATCACGCCG CCTCAACCAC TATGTTCTGT ATAAGGCTGT GCAGGGCTTC 
TTCACTTCAA ATAATGCCAC TCGAGACTTT TTGCTCCCCT TCCTGGAAGA GCCCATGGAC 
ACAGAGGCTG ATTTACAGTT CCGTCCCCGC ACGGGAAAAG CTGCGTCGAC ACCCCTCCTG 
CCTGAAGTGG AAGCCTATCT CCAACTCCTC GTGGTCATCT TCATGATGAA CAGCAAGCGC 
TACAAAGAGG CACAGAAGAT CTCTGATGAT CTGATGCAGA AGATCAGTAC TCAGAACCGC 
CGGGCCCTAG ACCTTGTAGC CGCAAAGTGT TACTATTATC ACGCCCGGGT CTATGAGTTC 
CTGGACAAGC TGGATGTGGT GCGCAGCTTC TTGCATGCTC GGCTCCGGAC AGCTACGCTT 
CGGCATGACG CAGACGGGCA GGCCACCCTG TTGAACCTCC TGCTGCGGAA TTACCTACAC 
TACAGCTTGT ACGACCAGGC TGAGAAGCTG GTGTCCAAGT CTGTGTTCCC AGAGCAGGCC 
AACAACAATG AGTGGGCCAG GTACCTCTAC TACACAGGGC GAATCAAAGC CATCCAGCTG 
GAGTACTCAG AGGCCCGGAG AACGATGACC AACGCCCTTC GCAAGGCCCC TCAGCACACA 
GCTGTCGGCT TCAAACAGAC GGTGCACAAG CTTCTCATCG TGGTGGAGCT GTTGCTGGGG 
GAGATCCCTG ACCGGCTGCA GTTCCGCCAG CCCTCCCTCA AGCGCTCACT CATGCCCTAT 
TTCCTTCTGA CTCAAGCTGT CAGGACAGGA AACCTAGCCA AGTTCAACCA GGTCCTGGAT 
CAGTTTGGGG AGAAGTTTCA AGCAGATGGG ACCTACACCC TAATTATCCG GCTGCGGCAC 
AACGTGATTA AGACAGGTGT ACGCATGATC AGCCTCTCCT ATTCCCGAAT CTCCTTGGCT 
GACATCGCCC AGAAGCTGCA GTTGGATAGC CCCGAAGATG CAGAGTTCAT TGTTGCCAAG 
GCCATCCGGG ATGGTGTCAT TGAGGCCAGC ATCAACCACG AGAAGGGCTA TGTCCAATCC 
AAGGAGATGA TTGACATCTA TTCCACCCGA GAGCCCCAGC TAGCCTTCCA CCAGCGCATC 
TCCTTCTGCC TAGATATCCA CAACATGTCT GTCAAGGCCA TGAGGTTTCC TCCCAAATCG 
TACAACAAGG ACTTGGAGTC TGCAGAGGAA CGGCGTGAGC GAGAACAGCA GGACTTGGAG 
TTTGCCAAGG AGATGGCAGA AGATGATGAT GACAGCTTCC CTTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

PubMed

Mutations in proteasome-related genes are associated with thyroid hemiagenesis.
Endocrine56(2)279-285(2017 May)
Budny B,Szczepanek-Parulska E,Zemojtel T,Szaflarski W,Rydzanicz M,Wesoly J,Handschuh L,Wolinski K,Piatek K,Niedziela M,Ziemnicka K,Figlerowicz M,Zabel M,Ruchala M

Polymorphisms and haplotypes of the chromosome locus 17q12-17q21.1 contribute to adult asthma susceptibility in Slovenian patients.
Human immunology77(6)527-34(2016 Jun)
?avbi M,Koro?ec P,Fle?ar M,?krgat Kristan S,Marc Malovrh M,Rijavec M

Widespread macromolecular interaction perturbations in human genetic disorders.
Cell161(3)647-660(2015 Apr)
Sahni N,Yi S,Taipale M,Fuxman Bass JI,Coulombe-Huntington J,Yang F,Peng J,Weile J,Karras GI,Wang Y,Kov?cs IA,Kamburov A,Krykbaeva I,Lam MH,Tucker G,Khurana V,Sharma A,Liu YY,Yachie N,Zhong Q,Shen Y,Palagi A,San-Miguel A,Fan C,Balcha D,Dricot A,Jordan DM,Walsh JM,Shah AA,Yang X,Stoyanova AK,Leighton A,Calderwood MA,Jacob Y,Cusick ME,Salehi-Ashtiani K,Whitesell LJ,Sunyaev S,Berger B,Barab?si AL,Charloteaux B,Hill DE,Hao T,Roth FP,Xia Y,Walhout AJM,Lindquist S,Vidal M

Phospho-tyrosine dependent protein-protein interaction network.
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Identification of Novel Proteins Co-Purifying with Cockayne Syndrome Group B (CSB) Reveals Potential Roles for CSB in RNA Metabolism and Chromatin Dynamics.
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PSMD3 cDNA ORF clone, Homo sapiens(human)

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