DAZ2 cDNA ORF clone, Homo sapiens(human)

Gene
Clones
gRNAs

Summary

Gene Symbol	DAZ2
Entrez Gene ID	57055
Full Name	deleted in azoospermia 2
Synonyms	pDP1678
General protein information	Preferred Names deleted in azoospermia 2 Names deleted in azoospermia protein 2
Gene Type	protein-coding
Organism	Homo sapiens(human)
Genome	Chromosome: Y Map Location: Yq11.223
Summary	This gene is a member of the DAZ gene family and is a candidate for the human Y-chromosomal azoospermia factor (AZF). Its expression is restricted to premeiotic germ cells, particularly in spermatogonia. It encodes an RNA-binding protein that is important for spermatogenesis. Four copies of this gene are found on chromosome Y within palindromic duplications; one pair of genes is part of the P2 palindrome and the second pair is part of the P1 palindrome. Each gene contains a 2.4 kb repeat including a 72-bp exon, called the DAZ repeat; the number of DAZ repeats is variable and there are several variations in the sequence of the DAZ repeat. Each copy of the gene also contains a 10.8 kb region that may be amplified; this region includes five exons that encode an RNA recognition motif (RRM) domain. This gene contains one copy of the 10.8 kb repeat. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Jul 2008].
Disorder MIM:	400026

mRNA and Protein(s)

mRNA	Protein	Name
NM_001005786.2	NP_001005786.2	deleted in azoospermia protein 2 isoform 3
NM_020363.3	NP_065096.2	deleted in azoospermia protein 2 isoform 1
NM_001005785.2	NP_001005785.1	deleted in azoospermia protein 2 isoform 2

Pathways from BioSystems

Homologies

Gallus gallus (chicken)	DAZL	NP_989549.1
Xenopus tropicalis (tropical clawed frog)	dazl	NP_989079.1
Pan troglodytes (chimpanzee)	DAZ2	XP_001138045.3
Danio rerio (zebrafish)	dazl	NP_571599.1
Rattus norvegicus (Norway rat)	Dazl	NP_001102884.1
Homo sapiens (human)	DAZ2	NP_001005785.1
	DAZ2	XP_002803072.1
Mus musculus (house mouse)	Dazl	NP_034151.3

Gene Ontology
Bibliography

Related articles in PubMed

gr/gr-DAZ2-DAZ4-CDY1b deletion is a high-risk factor for male infertility in Tunisian population.
Ghorbel M, Baklouti-Gargouri S, Keskes R, Chakroun N, Sellami A, Fakhfakh F, Ammar-Keskes L
Gene592(1)29-35(2016 Oct)

Impact of partial DAZ1/2 deletion and partial DAZ3/4 deletion on male infertility.
Zhang Y, Li M, Xiao F, Teng R, Zhang C, Lan A, Gu K, Li J, Wang D, Li H, Jiang L, Zeng S, He M, Huang Y, Guo P, Zhang X, Yang X
Gene571(1)9-16(2015 Oct)

Combined deletion of DAZ2 and DAZ4 copies of Y chromosome DAZ gene is associated with male infertility in Tunisian men.
Ghorbel M, Baklouti-Gargouri S, Keskes R, Chakroun N, Sellami A, Fakhfakh F, Ammar-Keskes L
Gene547(2)191-4(2014 Sep)

Association of DAZ1/DAZ2 deletion with spermatogenic impairment and male infertility in the South Chinese population.
Li Q, Qiao D, Song NH, Ding Y, Wang ZJ, Yang J, Wang W, Yin CJ
World journal of urology31(6)1403-9(2013 Dec)

Polymorphic expression of DAZ proteins in the human testis.
Kim B, Lee Y, Kim Y, Lee KH, Chun S, Rhee K, Seo JT, Kim SW, Paick JS
Human reproduction (Oxford, England)24(6)1507-15(2009 Jun)

GeneRIFs: Gene References Into Functions What's a GeneRIF?

study reported a new type of AZFc deletion (gr/gr-DAZ2-DAZ4-CDY1b) and hypothesis that this new deletion is the result of 2 successive events favored by the unstable structure of AZFc region; also demonstrated that this deletion constitutes a relative high-risk factor for male infertility in Tunisian population
Title: gr/gr-DAZ2-DAZ4-CDY1b deletion is a high-risk factor for male infertility in Tunisian population.

Studies indicate that partial RNA-binding proteins DAZ1/2 deletion was associated wih male infertility, but partial RNA-binding proteins DAZ3/4 deletion was not associated with male infertility.
Title: Impact of partial DAZ1/2 deletion and partial DAZ3/4 deletion on male infertility.

Deletion of DAZ2 and DAZ4 gene copies is associated with male infertility.
Title: Combined deletion of DAZ2 and DAZ4 copies of Y chromosome DAZ gene is associated with male infertility in Tunisian men.

There appears to be an asociation of DAZ1/DAZ2 deletion with spermatogenic impairment and male infertility in the South Chinese population.
Title: Association of DAZ1/DAZ2 deletion with spermatogenic impairment and male infertility in the South Chinese population.

All four DAZ genes are expressed in the human testis, and their products are highly polymorphic among men
Title: Polymorphic expression of DAZ proteins in the human testis.

The following DAZ2 gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the DAZ2 cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1⁺/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.

***CloneID	Accession No.	Definition	**Vector	*Turnaround time	Price (USD)
OHu32227	NM_001005785.2 Latest version!	Homo sapiens deleted in azoospermia 2 (DAZ2), transcript variant 2, mRNA.	pcDNA3.1-C-(k)DYK or customized vector	in pcDNA3.1-C-(k)DYK	$189.50-$265.30 $379.00
OHu08684	NM_001005786.2 Latest version!	Homo sapiens deleted in azoospermia 2 (DAZ2), transcript variant 3, mRNA.	pcDNA3.1-C-(k)DYK or customized vector	TBD	$216.30 $309.00
OHu22923	NM_020363.3 Latest version!	Homo sapiens deleted in azoospermia 2 (DAZ2), transcript variant 1, mRNA.	pcDNA3.1-C-(k)DYK or customized vector	TBD	$307.30 $439.00

ORF Online Only Promotion

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** You may select a custom vector to replace pcDNA3.1+/C-(K)DYK after clone is added to cart.

** GenScript guarantees 100% sequence accuracy of all synthetic DNA constructs we deliver, but we do not guarantee protein expression in your experimental system. Protein expression is influenced by many factors that may vary between experiments or laboratories. In addition, please pay attention to the signal peptide, propeptide and transit peptide in target ORF, which may affect the choice of vector (N/C terminal tag vector).

***One clone ID might be correlated to multiple accession numbers, which share the same CDS sequence.

Reference Sequences (Refseq)

DAZ2 ( NM_001005785.2 ) cDNA ORF clone, Homo sapiens(human) -> NP_001005785.1 Homo sapiens deleted in azoospermia 2 (DAZ2), transcript variant 2, mRNA.

Price & Availability↑

CloneID	OHu32227
Clone ID Related Accession (Same CDS sequence)	NM_001005785.2
Accession Version	NM_001005785.2 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 1605bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-09-21
Organism	Homo sapiens(human)
Product	deleted in azoospermia protein 2 isoform 2
Comment	Comment: REVIEWED REFSEQ: This record has been curated by NCBI staff. The reference sequence was derived from AK302690.1 and AF414184.1. On Jan 26, 2011 this sequence version replaced NM_001005785.1. Transcript Variant: This variant (2) has multiple differences in the coding region but maintains the reading frame, compared to variant 1. Variant 2 encodes isoform 2 which lacks one DAZ repeat, compared to isoform 1. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: AF414184.1, BC113006.1 [ECO:0000332] RNAseq introns :: mixed/partial sample support SAMEA1968968, SAMEA2148093 [ECO:0000350] ##Evidence-Data-END## COMPLETENESS: complete on the 3' end.

ATGTCTGCTG CAAATCCTGA GACTCCAAAC TCAACCATCT CCAGAGAGGC CAGCACCCAG 
TCTTCATCAG CTGCAGCTAG CCAAGGCTGG GTGTTACCAG AAGGCAAAAT CGTGCCAAAC 
ACTGTTTTTG TTGGTGGAAT TGATGCTAGG ATGGATGAAA CTGAGATTGG AAGCTGCTTT 
GGTAGATACG GTTCAGTGAA AGAAGTGAAG ATAATCACGA ATCGAACTGG TGTGTCCAAA 
GGCTATGGAT TTGTTTCGTT TGTTAATGAC GTGGATGTCC AGAAGATAGT AGGATCACAG 
ATACATTTCC ATGGTAAAAA GCTGAAGCTG GGCCCTGCAA TCAGGAAACA AAAGTTATGT 
GCTCGTCATG TGCAGCCACG TCCTTTGGTA GTTAATCCTC CTCCTCCACC ACAGTTTCAG 
AACGTCTGGC GGAATCCAAA CACTGAAACC TACCTGCAGC CCCAAATCAC GCCGAATCCT 
GTAACTCAGC ACGTTCAGGC TTATTCTGCT TATCCACATT CACCAGGTCA GGTCATCACT 
GGATGTCAGT TGCTTGTATA TAATTATCAG GAATATCCTA CTTATCCCGA TTCAGCATTT 
CAGGTCACCA CTGGATATCA GTTGCCTGTA TATAATTATC AGCCATTTCC TGCTTATCCA 
AGATCACCAT TTCAGGTCAC TGCTGGATAT CAGTTGCCTG TATATAATTA TCAGGCATTT 
CCTGCTTATC CAAATTCACC ATTTCAAGTC GCCACTGGAT ATCAGTTCCC TGTATACAAT 
TATCAGCCAT TTCCTGCTTA TCCAAGTTCA CCATTTCAGG TCACTGCTGG ATATCAGTTG 
CCTGTATATA ATTATCAGGC ATTTCCTGCT TATCCAAATT CACCATTTCA AGTCGCCACT 
GGATATCAGT TCCCTGTATA CAATTATCAG GCATTTCCTG CTTATCCAAA TTCACCAGTT 
CAGGTCACCA CTGGATATCA GTTGCCTGTA TACAATTATC AGGCATTTCC TGCTTATCCA 
AGTTCACCAT TTCAGGTCAC CACTGGATAT CAGTTGCCTG TATATAATTA TCAGGCATTT 
CCTGCTTATC CAAGTTCACC ATTTCAGGTC ACCACTGGAT ATCAGTTGCC TGTATATAAT 
TATCAGGCAT TTCCTGCTTA TCCAAGTTCA CCATTTCAGG TCACCACTGG ATATCAGTTG 
CCTGTATATA ATTATCAGGC ATTTCCTGCT TATCCAAGTT CACCATTTCA GGTCACCACT 
GGATATCAGT TGCCTGTATA TAATTATCAG GCATTTCCTG CTTATCCAAG TTCACCATTT 
CAGGTCACCA CTGGATATCA GTTGCCTGTA TATAATTATC AGGCATTTCC TGCTTATCCA 
AGTTCACCAT TTCAGGTCAC CACTGGATAT CAGTTGCCTG TATATAATTA TCAGGCATTT 
CCTGCTTATC CAAATTCAGC AGTTCAGGTC ACCACTGGAT ATCAGTTCCA TGTATACAAT 
TACCAGATGC CACCGCAGTG CCCTGTTGGG GAGCAAAGGA GAAATCTGTG GACCGAAGCA 
TACAAATGGT GGTATCTTGT CTGTTTAATC CAGAGAAGAG ACTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_001005785.1
CDS	285..1889
Translation	MSAANPETPNSTISREASTQSSSAAASQGWVLPEGKIVPNTVFVGGIDARMDETEIGSCFGRYGSVKEVKIITNRTGVSKGYGFVSFVNDVDVQKIVGSQIHFHGKKLKLGPAIRKQKLCARHVQPRPLVVNPPPPPQFQNVWRNPNTETYLQPQITPNPVTQHVQAYSAYPHSPGQVITGCQLLVYNYQEYPTYPDSAFQVTTGYQLPVYNYQPFPAYPRSPFQVTAGYQLPVYNYQAFPAYPNSPFQVATGYQFPVYNYQPFPAYPSSPFQVTAGYQLPVYNYQAFPAYPNSPFQVATGYQFPVYNYQAFPAYPNSPVQVTTGYQLPVYNYQAFPAYPSSPFQVTTGYQLPVYNYQAFPAYPSSPFQVTTGYQLPVYNYQAFPAYPSSPFQVTTGYQLPVYNYQAFPAYPSSPFQVTTGYQLPVYNYQAFPAYPSSPFQVTTGYQLPVYNYQAFPAYPSSPFQVTTGYQLPVYNYQAFPAYPNSAVQVTTGYQFHVYNYQMPPQCPVGEQRRNLWTEAYKWWYLVCLIQRRD

Target ORF information:

RefSeq Version	NM_001005785.2
Organism	Homo sapiens(human)
Definition	Homo sapiens deleted in azoospermia 2 (DAZ2), transcript variant 2, mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_001005785.2

ORF Insert Sequence:

ATGTCTGCTG CAAATCCTGA GACTCCAAAC TCAACCATCT CCAGAGAGGC CAGCACCCAG 
TCTTCATCAG CTGCAGCTAG CCAAGGCTGG GTGTTACCAG AAGGCAAAAT CGTGCCAAAC 
ACTGTTTTTG TTGGTGGAAT TGATGCTAGG ATGGATGAAA CTGAGATTGG AAGCTGCTTT 
GGTAGATACG GTTCAGTGAA AGAAGTGAAG ATAATCACGA ATCGAACTGG TGTGTCCAAA 
GGCTATGGAT TTGTTTCGTT TGTTAATGAC GTGGATGTCC AGAAGATAGT AGGATCACAG 
ATACATTTCC ATGGTAAAAA GCTGAAGCTG GGCCCTGCAA TCAGGAAACA AAAGTTATGT 
GCTCGTCATG TGCAGCCACG TCCTTTGGTA GTTAATCCTC CTCCTCCACC ACAGTTTCAG 
AACGTCTGGC GGAATCCAAA CACTGAAACC TACCTGCAGC CCCAAATCAC GCCGAATCCT 
GTAACTCAGC ACGTTCAGGC TTATTCTGCT TATCCACATT CACCAGGTCA GGTCATCACT 
GGATGTCAGT TGCTTGTATA TAATTATCAG GAATATCCTA CTTATCCCGA TTCAGCATTT 
CAGGTCACCA CTGGATATCA GTTGCCTGTA TATAATTATC AGCCATTTCC TGCTTATCCA 
AGATCACCAT TTCAGGTCAC TGCTGGATAT CAGTTGCCTG TATATAATTA TCAGGCATTT 
CCTGCTTATC CAAATTCACC ATTTCAAGTC GCCACTGGAT ATCAGTTCCC TGTATACAAT 
TATCAGCCAT TTCCTGCTTA TCCAAGTTCA CCATTTCAGG TCACTGCTGG ATATCAGTTG 
CCTGTATATA ATTATCAGGC ATTTCCTGCT TATCCAAATT CACCATTTCA AGTCGCCACT 
GGATATCAGT TCCCTGTATA CAATTATCAG GCATTTCCTG CTTATCCAAA TTCACCAGTT 
CAGGTCACCA CTGGATATCA GTTGCCTGTA TACAATTATC AGGCATTTCC TGCTTATCCA 
AGTTCACCAT TTCAGGTCAC CACTGGATAT CAGTTGCCTG TATATAATTA TCAGGCATTT 
CCTGCTTATC CAAGTTCACC ATTTCAGGTC ACCACTGGAT ATCAGTTGCC TGTATATAAT 
TATCAGGCAT TTCCTGCTTA TCCAAGTTCA CCATTTCAGG TCACCACTGG ATATCAGTTG 
CCTGTATATA ATTATCAGGC ATTTCCTGCT TATCCAAGTT CACCATTTCA GGTCACCACT 
GGATATCAGT TGCCTGTATA TAATTATCAG GCATTTCCTG CTTATCCAAG TTCACCATTT 
CAGGTCACCA CTGGATATCA GTTGCCTGTA TATAATTATC AGGCATTTCC TGCTTATCCA 
AGTTCACCAT TTCAGGTCAC CACTGGATAT CAGTTGCCTG TATATAATTA TCAGGCATTT 
CCTGCTTATC CAAATTCAGC AGTTCAGGTC ACCACTGGAT ATCAGTTCCA TGTATACAAT 
TACCAGATGC CACCGCAGTG CCCTGTTGGG GAGCAAAGGA GAAATCTGTG GACCGAAGCA 
TACAAATGGT GGTATCTTGT CTGTTTAATC CAGAGAAGAG ACTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

DAZ2 ( NM_001005786.2 ) cDNA ORF clone, Homo sapiens(human) -> NP_001005786.2 Homo sapiens deleted in azoospermia 2 (DAZ2), transcript variant 3, mRNA.

Price & Availability↑

CloneID	OHu08684
Clone ID Related Accession (Same CDS sequence)	NM_001005786.2
Accession Version	NM_001005786.2 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 1101bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-09-21
Organism	Homo sapiens(human)
Product	deleted in azoospermia protein 2 isoform 3
Comment	Comment: REVIEWED REFSEQ: This record has been curated by NCBI staff. The reference sequence was derived from AK302690.1, U21663.1, AC053490.2 and AF414184.1. On or before Aug 31, 2013 this sequence version replaced XM_005262601.1, NM_001005786.1. Transcript Variant: This variant (3) lacks several in-frame exons in the coding region, compared to variant 1. Variant 3 encodes isoform 3 which lacks eight DAZ repeats, compared to isoform 1. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: U21663.1 [ECO:0000332] RNAseq introns :: mixed/partial sample support SAMEA1968968, SAMEA2148093 [ECO:0000350] ##Evidence-Data-END## COMPLETENESS: complete on the 3' end.

ATGTCTGCTG CAAATCCTGA GACTCCAAAC TCAACCATCT CCAGAGAGGC CAGCACCCAG 
TCTTCATCAG CTGCAGCTAG CCAAGGCTGG GTGTTACCAG AAGGCAAAAT CGTGCCAAAC 
ACTGTTTTTG TTGGTGGAAT TGATGCTAGG ATGGATGAAA CTGAGATTGG AAGCTGCTTT 
GGTAGATACG GTTCAGTGAA AGAAGTGAAG ATAATCACGA ATCGAACTGG TGTGTCCAAA 
GGCTATGGAT TTGTTTCGTT TGTTAATGAC GTGGATGTCC AGAAGATAGT AGGATCACAG 
ATACATTTCC ATGGTAAAAA GCTGAAGCTG GGCCCTGCAA TCAGGAAACA AAAGTTATGT 
GCTCGTCATG TGCAGCCACG TCCTTTGGTA GTTAATCCTC CTCCTCCACC ACAGTTTCAG 
AACGTCTGGC GGAATCCAAA CACTGAAACC TACCTGCAGC CCCAAATCAC GCCGAATCCT 
GTAACTCAGC ACGTTCAGGC TTATTCTGCT TATCCACATT CACCAGGTCA GGTCATCACT 
GGATGTCAGT TGCTTGTATA TAATTATCAG GAATATCCTA CTTATCCCGA TTCAGCATTT 
CAGGTCACCA CTGGATATCA GTTGCCTGTA TATAATTATC AGCCATTTCC TGCTTATCCA 
AGTTCACCAT TTCAGGTCAC TGCTGGATAT CAGTTGCCTG TATATAATTA TCAGGCATTT 
CCTGCTTATC CAAGTTCACC ATTTCAGGTC ACCACTGGAT ATCAGTTGCC TGTATATAAT 
TATCAGGCAT TTCCTGCTTA TCCAAGTTCA CCATTTCAGG TCACCACTGG ATATCAGTTG 
CCTGTATATA ATTATCAGGC ATTTCCTGCT TATCCAAGTT CACCATTTCA GGTCACCACT 
GGATATCAGT TGCCTGTATA TAATTATCAG GCATTTCCTG CTTATCCAAA TTCAGCAGTT 
CAGGTCACCA CTGGATATCA GTTCCATGTA TACAATTACC AGATGCCACC GCAGTGCCCT 
GTTGGGGAGC AAAGGAGAAA TCTGTGGACC GAAGCATACA AATGGTGGTA TCTTGTCTGT 
TTAATCCAGA GAAGAGACTG A

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_001005786.2
CDS	285..1385
Translation	MSAANPETPNSTISREASTQSSSAAASQGWVLPEGKIVPNTVFVGGIDARMDETEIGSCFGRYGSVKEVKIITNRTGVSKGYGFVSFVNDVDVQKIVGSQIHFHGKKLKLGPAIRKQKLCARHVQPRPLVVNPPPPPQFQNVWRNPNTETYLQPQITPNPVTQHVQAYSAYPHSPGQVITGCQLLVYNYQEYPTYPDSAFQVTTGYQLPVYNYQPFPAYPSSPFQVTAGYQLPVYNYQAFPAYPSSPFQVTTGYQLPVYNYQAFPAYPSSPFQVTTGYQLPVYNYQAFPAYPSSPFQVTTGYQLPVYNYQAFPAYPNSAVQVTTGYQFHVYNYQMPPQCPVGEQRRNLWTEAYKWWYLVCLIQRRD

Target ORF information:

RefSeq Version	NM_001005786.2
Organism	Homo sapiens(human)
Definition	Homo sapiens deleted in azoospermia 2 (DAZ2), transcript variant 3, mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_001005786.2

ORF Insert Sequence:

ATGTCTGCTG CAAATCCTGA GACTCCAAAC TCAACCATCT CCAGAGAGGC CAGCACCCAG 
TCTTCATCAG CTGCAGCTAG CCAAGGCTGG GTGTTACCAG AAGGCAAAAT CGTGCCAAAC 
ACTGTTTTTG TTGGTGGAAT TGATGCTAGG ATGGATGAAA CTGAGATTGG AAGCTGCTTT 
GGTAGATACG GTTCAGTGAA AGAAGTGAAG ATAATCACGA ATCGAACTGG TGTGTCCAAA 
GGCTATGGAT TTGTTTCGTT TGTTAATGAC GTGGATGTCC AGAAGATAGT AGGATCACAG 
ATACATTTCC ATGGTAAAAA GCTGAAGCTG GGCCCTGCAA TCAGGAAACA AAAGTTATGT 
GCTCGTCATG TGCAGCCACG TCCTTTGGTA GTTAATCCTC CTCCTCCACC ACAGTTTCAG 
AACGTCTGGC GGAATCCAAA CACTGAAACC TACCTGCAGC CCCAAATCAC GCCGAATCCT 
GTAACTCAGC ACGTTCAGGC TTATTCTGCT TATCCACATT CACCAGGTCA GGTCATCACT 
GGATGTCAGT TGCTTGTATA TAATTATCAG GAATATCCTA CTTATCCCGA TTCAGCATTT 
CAGGTCACCA CTGGATATCA GTTGCCTGTA TATAATTATC AGCCATTTCC TGCTTATCCA 
AGTTCACCAT TTCAGGTCAC TGCTGGATAT CAGTTGCCTG TATATAATTA TCAGGCATTT 
CCTGCTTATC CAAGTTCACC ATTTCAGGTC ACCACTGGAT ATCAGTTGCC TGTATATAAT 
TATCAGGCAT TTCCTGCTTA TCCAAGTTCA CCATTTCAGG TCACCACTGG ATATCAGTTG 
CCTGTATATA ATTATCAGGC ATTTCCTGCT TATCCAAGTT CACCATTTCA GGTCACCACT 
GGATATCAGT TGCCTGTATA TAATTATCAG GCATTTCCTG CTTATCCAAA TTCAGCAGTT 
CAGGTCACCA CTGGATATCA GTTCCATGTA TACAATTACC AGATGCCACC GCAGTGCCCT 
GTTGGGGAGC AAAGGAGAAA TCTGTGGACC GAAGCATACA AATGGTGGTA TCTTGTCTGT 
TTAATCCAGA GAAGAGACTG A

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

DAZ2 ( NM_020363.3 ) cDNA ORF clone, Homo sapiens(human) -> NP_065096.2 Homo sapiens deleted in azoospermia 2 (DAZ2), transcript variant 1, mRNA.

Price & Availability↑

CloneID	OHu22923
Clone ID Related Accession (Same CDS sequence)	NM_020363.3
Accession Version	NM_020363.3 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 1677bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-09-21
Organism	Homo sapiens(human)
Product	deleted in azoospermia protein 2 isoform 1
Comment	Comment: REVIEWED REFSEQ: This record has been curated by NCBI staff. The reference sequence was derived from AK302690.1, AF248480.1 and AC006983.4. This sequence is a reference standard in the RefSeqGene project. On Jan 26, 2011 this sequence version replaced NM_020363.2. Transcript Variant: This variant (1) represents the longest transcript. Variant 1 encodes isoform 1 which includes 15 DAZ repeats. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: AF248480.1 [ECO:0000332] RNAseq introns :: mixed/partial sample support SAMEA1968968, SAMEA2148093 [ECO:0000350] ##Evidence-Data-END## ##RefSeq-Attributes-START## RefSeq Select criteria :: based on conservation, expression, longest protein ##RefSeq-Attributes-END## COMPLETENESS: complete on the 3' end.

ATGTCTGCTG CAAATCCTGA GACTCCAAAC TCAACCATCT CCAGAGAGGC CAGCACCCAG 
TCTTCATCAG CTGCAGCTAG CCAAGGCTGG GTGTTACCAG AAGGCAAAAT CGTGCCAAAC 
ACTGTTTTTG TTGGTGGAAT TGATGCTAGG ATGGATGAAA CTGAGATTGG AAGCTGCTTT 
GGTAGATACG GTTCAGTGAA AGAAGTGAAG ATAATCACGA ATCGAACTGG TGTGTCCAAA 
GGCTATGGAT TTGTTTCGTT TGTTAATGAC GTGGATGTCC AGAAGATAGT AGGATCACAG 
ATACATTTCC ATGGTAAAAA GCTGAAGCTG GGCCCTGCAA TCAGGAAACA AAAGTTATGT 
GCTCGTCATG TGCAGCCACG TCCTTTGGTA GTTAATCCTC CTCCTCCACC ACAGTTTCAG 
AACGTCTGGC GGAATCCAAA CACTGAAACC TACCTGCAGC CCCAAATCAC GCCGAATCCT 
GTAACTCAGC ACGTTCAGGC TTATTCTGCT TATCCACATT CACCAGGTCA GGTCATCACT 
GGATGTCAGT TGCTTGTATA TAATTATCAG GAATATCCTA CTTATCCCGA TTCAGCATTT 
CAGGTCACCA CTGGATATCA GTTGCCTGTA TATAATTATC AGCCATTTCC TGCTTATCCA 
AGATCACCAT TTCAGGTCAC TGCTGGATAT CAGTTGCCTG TATATAATTA TCAGGCATTT 
CCTGCTTATC CAAATTCACC ATTTCAAGTC GCCACTGGAT ATCAGTTCCC TGTATACAAT 
TATCAGCCAT TTCCTGCTTA TCCAAGTTCA CCATTTCAGG TCACTGCTGG ATATCAGTTG 
CCTGTATATA ATTATCAGGC ATTTCCTGCT TATCCAAATT CACCATTTCA AGTCGCCACT 
GGATATCAGT TCCCTGTATA CAATTATCAG GCATTTCCTG CTTATCCAAA TTCACCAGTT 
CAGGTCACCA CTGGATATCA GTTGCCTGTA TACAATTATC AGGCATTTCC TGCTTATCCA 
AATTCACCAG TTCAGGTCAC CACTGGATAT CAGTTGCCTG TATACAATTA TCAGGCATTT 
CCTGCTTATC CAAGTTCACC ATTTCAGGTC ACCACTGGAT ATCAGTTGCC TGTATATAAT 
TATCAGGCAT TTCCTGCTTA TCCAAGTTCA CCATTTCAGG TCACCACTGG ATATCAGTTG 
CCTGTATATA ATTATCAGGC ATTTCCTGCT TATCCAAGTT CACCATTTCA GGTCACCACT 
GGATATCAGT TGCCTGTATA TAATTATCAG GCATTTCCTG CTTATCCAAG TTCACCATTT 
CAGGTCACCA CTGGATATCA GTTGCCTGTA TATAATTATC AGGCATTTCC TGCTTATCCA 
AGTTCACCAT TTCAGGTCAC CACTGGATAT CAGTTGCCTG TATATAATTA TCAGGCATTT 
CCTGCTTATC CAAGTTCACC ATTTCAGGTC ACCACTGGAT ATCAGTTGCC TGTATATAAT 
TATCAGGCAT TTCCTGCTTA TCCAAATTCA GCAGTTCAGG TCACCACTGG ATATCAGTTC 
CATGTATACA ATTACCAGAT GCCACCGCAG TGCCCTGTTG GGGAGCAAAG GAGAAATCTG 
TGGACCGAAG CATACAAATG GTGGTATCTT GTCTGTTTAA TCCAGAGAAG AGACTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_065096.2
CDS	285..1961
Translation	MSAANPETPNSTISREASTQSSSAAASQGWVLPEGKIVPNTVFVGGIDARMDETEIGSCFGRYGSVKEVKIITNRTGVSKGYGFVSFVNDVDVQKIVGSQIHFHGKKLKLGPAIRKQKLCARHVQPRPLVVNPPPPPQFQNVWRNPNTETYLQPQITPNPVTQHVQAYSAYPHSPGQVITGCQLLVYNYQEYPTYPDSAFQVTTGYQLPVYNYQPFPAYPRSPFQVTAGYQLPVYNYQAFPAYPNSPFQVATGYQFPVYNYQPFPAYPSSPFQVTAGYQLPVYNYQAFPAYPNSPFQVATGYQFPVYNYQAFPAYPNSPVQVTTGYQLPVYNYQAFPAYPNSPVQVTTGYQLPVYNYQAFPAYPSSPFQVTTGYQLPVYNYQAFPAYPSSPFQVTTGYQLPVYNYQAFPAYPSSPFQVTTGYQLPVYNYQAFPAYPSSPFQVTTGYQLPVYNYQAFPAYPSSPFQVTTGYQLPVYNYQAFPAYPSSPFQVTTGYQLPVYNYQAFPAYPNSAVQVTTGYQFHVYNYQMPPQCPVGEQRRNLWTEAYKWWYLVCLIQRRD

Target ORF information:

RefSeq Version	NM_020363.3
Organism	Homo sapiens(human)
Definition	Homo sapiens deleted in azoospermia 2 (DAZ2), transcript variant 1, mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_020363.3

ORF Insert Sequence:

ATGTCTGCTG CAAATCCTGA GACTCCAAAC TCAACCATCT CCAGAGAGGC CAGCACCCAG 
TCTTCATCAG CTGCAGCTAG CCAAGGCTGG GTGTTACCAG AAGGCAAAAT CGTGCCAAAC 
ACTGTTTTTG TTGGTGGAAT TGATGCTAGG ATGGATGAAA CTGAGATTGG AAGCTGCTTT 
GGTAGATACG GTTCAGTGAA AGAAGTGAAG ATAATCACGA ATCGAACTGG TGTGTCCAAA 
GGCTATGGAT TTGTTTCGTT TGTTAATGAC GTGGATGTCC AGAAGATAGT AGGATCACAG 
ATACATTTCC ATGGTAAAAA GCTGAAGCTG GGCCCTGCAA TCAGGAAACA AAAGTTATGT 
GCTCGTCATG TGCAGCCACG TCCTTTGGTA GTTAATCCTC CTCCTCCACC ACAGTTTCAG 
AACGTCTGGC GGAATCCAAA CACTGAAACC TACCTGCAGC CCCAAATCAC GCCGAATCCT 
GTAACTCAGC ACGTTCAGGC TTATTCTGCT TATCCACATT CACCAGGTCA GGTCATCACT 
GGATGTCAGT TGCTTGTATA TAATTATCAG GAATATCCTA CTTATCCCGA TTCAGCATTT 
CAGGTCACCA CTGGATATCA GTTGCCTGTA TATAATTATC AGCCATTTCC TGCTTATCCA 
AGATCACCAT TTCAGGTCAC TGCTGGATAT CAGTTGCCTG TATATAATTA TCAGGCATTT 
CCTGCTTATC CAAATTCACC ATTTCAAGTC GCCACTGGAT ATCAGTTCCC TGTATACAAT 
TATCAGCCAT TTCCTGCTTA TCCAAGTTCA CCATTTCAGG TCACTGCTGG ATATCAGTTG 
CCTGTATATA ATTATCAGGC ATTTCCTGCT TATCCAAATT CACCATTTCA AGTCGCCACT 
GGATATCAGT TCCCTGTATA CAATTATCAG GCATTTCCTG CTTATCCAAA TTCACCAGTT 
CAGGTCACCA CTGGATATCA GTTGCCTGTA TACAATTATC AGGCATTTCC TGCTTATCCA 
AATTCACCAG TTCAGGTCAC CACTGGATAT CAGTTGCCTG TATACAATTA TCAGGCATTT 
CCTGCTTATC CAAGTTCACC ATTTCAGGTC ACCACTGGAT ATCAGTTGCC TGTATATAAT 
TATCAGGCAT TTCCTGCTTA TCCAAGTTCA CCATTTCAGG TCACCACTGG ATATCAGTTG 
CCTGTATATA ATTATCAGGC ATTTCCTGCT TATCCAAGTT CACCATTTCA GGTCACCACT 
GGATATCAGT TGCCTGTATA TAATTATCAG GCATTTCCTG CTTATCCAAG TTCACCATTT 
CAGGTCACCA CTGGATATCA GTTGCCTGTA TATAATTATC AGGCATTTCC TGCTTATCCA 
AGTTCACCAT TTCAGGTCAC CACTGGATAT CAGTTGCCTG TATATAATTA TCAGGCATTT 
CCTGCTTATC CAAGTTCACC ATTTCAGGTC ACCACTGGAT ATCAGTTGCC TGTATATAAT 
TATCAGGCAT TTCCTGCTTA TCCAAATTCA GCAGTTCAGG TCACCACTGG ATATCAGTTC 
CATGTATACA ATTACCAGAT GCCACCGCAG TGCCCTGTTG GGGAGCAAAG GAGAAATCTG 
TGGACCGAAG CATACAAATG GTGGTATCTT GTCTGTTTAA TCCAGAGAAG AGACTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

PubMed

gr/gr-DAZ2-DAZ4-CDY1b deletion is a high-risk factor for male infertility in Tunisian population.
Gene592(1)29-35(2016 Oct)
Ghorbel M,Baklouti-Gargouri S,Keskes R,Chakroun N,Sellami A,Fakhfakh F,Ammar-Keskes L

Impact of partial DAZ1/2 deletion and partial DAZ3/4 deletion on male infertility.
Gene571(1)9-16(2015 Oct)
Zhang Y,Li M,Xiao F,Teng R,Zhang C,Lan A,Gu K,Li J,Wang D,Li H,Jiang L,Zeng S,He M,Huang Y,Guo P,Zhang X,Yang X

Combined deletion of DAZ2 and DAZ4 copies of Y chromosome DAZ gene is associated with male infertility in Tunisian men.
Gene547(2)191-4(2014 Sep)
Ghorbel M,Baklouti-Gargouri S,Keskes R,Chakroun N,Sellami A,Fakhfakh F,Ammar-Keskes L

Association of DAZ1/DAZ2 deletion with spermatogenic impairment and male infertility in the South Chinese population.
World journal of urology31(6)1403-9(2013 Dec)
Li Q,Qiao D,Song NH,Ding Y,Wang ZJ,Yang J,Wang W,Yin CJ

Polymorphic expression of DAZ proteins in the human testis.
Human reproduction (Oxford, England)24(6)1507-15(2009 Jun)
Kim B,Lee Y,Kim Y,Lee KH,Chun S,Rhee K,Seo JT,Kim SW,Paick JS

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DAZ2 cDNA ORF clone, Homo sapiens(human)

Gene

Clones

gRNAs

Related articles in PubMed

Target ORF information:

Target ORF information:

ORF Insert Sequence:

Target ORF information:

Target ORF information:

ORF Insert Sequence:

Target ORF information:

Target ORF information:

ORF Insert Sequence:

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