PDXP cDNA ORF clone, Homo sapiens(human)

Gene
Clones
gRNAs

Summary

Gene Symbol	PDXP
Entrez Gene ID	57026
Full Name	pyridoxal phosphatase
Synonyms	CIN,PLP,dJ37E16.5
General protein information	Preferred Names pyridoxal phosphatase Names pyridoxal phosphate phosphatase PLP phosphatase chronophin pyridoxal (pyridoxine, vitamin B6) phosphatase testicular secretory protein Li 36
Gene Type	protein-coding
Organism	Homo sapiens(human)
Genome	Chromosome: 22 Map Location: 22q13.1
Summary	Pyridoxal 5-prime-phosphate (PLP) is the active form of vitamin B6 that acts as a coenzyme in maintaining biochemical homeostasis. The preferred degradation route from PLP to 4-pyridoxic acid involves the dephosphorylation of PLP by PDXP (Jang et al., 2003 [PubMed 14522954]).[supplied by OMIM, Mar 2008].
Disorder MIM:	609246

mRNA and Protein(s)

mRNA	Protein	Name
NM_020315.5	NP_064711.1	pyridoxal phosphate phosphatase
NM_020315.4	NP_064711.1	pyridoxal phosphate phosphatase

Pathways from BioSystems

Homologies

Homo sapiens (human)	PDXP	NP_064711.1
Canis lupus familiaris (dog)	PDXP	XP_003431551.1
Bos taurus (cattle)	PDXP	NP_001030207.1
Mus musculus (house mouse)	Pdxp	NP_064667.2
Gallus gallus (chicken)	LOC771207	XP_003640432.1
Arabidopsis thaliana (thale cress)	AT5G36790	NP_001190428.1
Arabidopsis thaliana (thale cress)	PGLP1	NP_001190427.1
Rattus norvegicus (Norway rat)	Pdxp	NP_001129291.1
Danio rerio (zebrafish)	zgc:194409	NP_001122177.1
Oryza sativa (rice)	Os04g0490800	NP_001053167.1
Pan troglodytes (chimpanzee)	PDXP	XP_003317269.1

Gene Ontology
Bibliography

Related articles in PubMed

Chronophin coordinates cell leading edge dynamics by controlling active cofilin levels.
Delorme-Walker V, Seo JY, Gohla A, Fowler B, Bohl B, DerMardirossian C
Proceedings of the National Academy of Sciences of the United States of America112(37)E5150-9(2015 Sep)

A novel Rac1 GAP splice variant relays poly-Ub accumulation signals to mediate Rac1 inactivation.
Huang TY, Michael S, Xu T, Sarkeshik A, Moresco JJ, Yates JR 3rd, Masliah E, Bokoch GM, DerMardirossian C
Molecular biology of the cell24(3)194-209(2013 Feb)

Genes linked to energy metabolism and immunoregulatory mechanisms are associated with subcutaneous adipose tissue distribution in HIV-infected men.
Irvin MR, Shrestha S, Chen YD, Wiener HW, Haritunians T, Vaughan LK, Tiwari HK, Taylor KD, Scherzer R, Saag MS, Grunfeld C, Rotter JI, Arnett DK
Pharmacogenetics and genomics21(12)798-807(2011 Dec)

Chronophin mediates an ATP-sensing mechanism for cofilin dephosphorylation and neuronal cofilin-actin rod formation.
Huang TY, Minamide LS, Bamburg JR, Bokoch GM
Developmental cell15(5)691-703(2008 Nov)

GeneRIFs: Gene References Into Functions What's a GeneRIF?

Chronophin has a role in coordinating cell leading edge dynamics by controlling active cofilin levels
Title: Chronophin coordinates cell leading edge dynamics by controlling active cofilin levels.

Splicing of SH3BP1 and CIN gene loci produces the novel brain specific splice variant BGIN.
Title: A novel Rac1 GAP splice variant relays poly-Ub accumulation signals to mediate Rac1 inactivation.

Study demonstrates the ATP-sensitive interaction of the cofilin phosphatase chronophin (CIN) with the chaperone hsp90 to form a biosensor that mediates cofilin/actin rod formation.
Title: Chronophin mediates an ATP-sensing mechanism for cofilin dephosphorylation and neuronal cofilin-actin rod formation.

Results suggest that the transduction of the PEP-1-PLPP fusion protein can be one mode of PLP level regulation, and to replenish this enzyme in the various neurological disorders related to vitamin B(6).
Title: Human brain pyridoxal-5'-phosphate phosphatase (PLPP):protein transduction of PEP-1-PLPP into PC12 cells.

analysis of brain pyridoxal-5'-phosphate phosphatase
Title: Human brain pyridoxal-5'-phosphate phosphatase: production and characterization of monoclonal antibodies.

The following PDXP gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the PDXP cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1⁺/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.

***CloneID	Accession No.	Definition	**Vector	*Turnaround time	Price (USD)
OHu30342	NM_020315.5 Latest version!	Homo sapiens pyridoxal phosphatase (PDXP), mRNA.	pcDNA3.1-C-(k)DYK or customized vector	in pcDNA3.1-C-(k)DYK	$154.50-$216.30 $309.00
View Old Accession Versions >>
OHu30342	NM_020315.4	Homo sapiens pyridoxal phosphatase (PDXP), mRNA.	pcDNA3.1-C-(k)DYK or customized vector	in pcDNA3.1-C-(k)DYK	$154.50-$216.30 $309.00
Hide Old Accession Versions >>

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** GenScript guarantees 100% sequence accuracy of all synthetic DNA constructs we deliver, but we do not guarantee protein expression in your experimental system. Protein expression is influenced by many factors that may vary between experiments or laboratories. In addition, please pay attention to the signal peptide, propeptide and transit peptide in target ORF, which may affect the choice of vector (N/C terminal tag vector).

***One clone ID might be correlated to multiple accession numbers, which share the same CDS sequence.

Reference Sequences (Refseq)

PDXP ( NM_020315.5 ) cDNA ORF clone, Homo sapiens(human) -> NP_064711.1 Homo sapiens pyridoxal phosphatase (PDXP), mRNA.

Price & Availability↑

CloneID	OHu30342
Clone ID Related Accession (Same CDS sequence)	NM_020315.5 , NM_020315.4
Accession Version	NM_020315.5 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 891bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-11-16
Organism	Homo sapiens(human)
Product	pyridoxal phosphate phosphatase
Comment	Comment: VALIDATED REFSEQ: This record has undergone validation or preliminary review. The reference sequence was derived from Z83844.5 and BC064922.1. On Nov 22, 2018 this sequence version replaced NM_020315.4. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: BC064922.1, SRR1163655.298190.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA1965299, SAMEA1966682 [ECO:0000348] ##Evidence-Data-END## ##RefSeq-Attributes-START## MANE Ensembl match :: ENST00000215904.7/ ENSP00000215904.6 RefSeq Select criteria :: based on single protein-coding transcript ##RefSeq-Attributes-END## COMPLETENESS: full length.

ATGGCGCGCT GCGAGAGGCT GCGCGGAGCG GCCCTGCGCG ACGTGCTGGG CCGGGCGCAG 
GGGGTCCTGT TCGACTGTGA CGGGGTGCTG TGGAACGGCG AGCGCGCCGT GCCGGGCGCC 
CCGGAGCTGC TGGAGCGGCT GGCGCGGGCC GGCAAGGCGG CTCTGTTTGT GAGCAACAAC 
AGCCGGCGCG CGCGGCCCGA GCTGGCCCTG CGCTTCGCGC GCCTCGGCTT CGGGGGGCTG 
CGCGCCGAGC AGCTCTTCAG CTCCGCGCTG TGCGCCGCGC GCCTGCTGCG CCAGCGCCTG 
CCCGGGCCTC CGGACGCGCC GGGCGCCGTG TTCGTGCTGG GCGGCGAGGG GCTGCGCGCC 
GAGCTGCGCG CCGCGGGGCT GCGCCTGGCC GGGGACCCGA GCGCGGGGGA CGGCGCGGCC 
CCGCGCGTGC GCGCCGTGCT TGTGGGCTAC GACGAGCACT TCTCCTTCGC CAAGCTGAGG 
GAGGCGTGCG CGCACCTGCG CGACCCCGAG TGCCTACTCG TGGCCACCGA CCGTGACCCA 
TGGCACCCGC TGAGCGACGG CAGCCGGACC CCTGGCACCG GGAGCCTGGC CGCTGCAGTG 
GAGACAGCCT CGGGACGCCA GGCCCTGGTG GTGGGCAAGC CCAGCCCCTA CATGTTCGAG 
TGCATCACGG AGAACTTCAG CATCGACCCC GCACGCACGC TTATGGTGGG TGACCGCCTG 
GAGACCGACA TCCTCTTTGG CCACCGCTGC GGCATGACCA CTGTGCTCAC GCTCACAGGA 
GTCTCCCGCC TAGAAGAGGC CCAGGCCTAC CTAGCGGCCG GCCAGCACGA CCTCGTGCCC 
CATTACTATG TGGAGAGCAT CGCAGACTTG ACAGAGGGGT TGGAGGACTG A

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_064711.1
CDS	61..951
Translation	MARCERLRGAALRDVLGRAQGVLFDCDGVLWNGERAVPGAPELLERLARAGKAALFVSNNSRRARPELALRFARLGFGGLRAEQLFSSALCAARLLRQRLPGPPDAPGAVFVLGGEGLRAELRAAGLRLAGDPSAGDGAAPRVRAVLVGYDEHFSFAKLREACAHLRDPECLLVATDRDPWHPLSDGSRTPGTGSLAAAVETASGRQALVVGKPSPYMFECITENFSIDPARTLMVGDRLETDILFGHRCGMTTVLTLTGVSRLEEAQAYLAAGQHDLVPHYYVESIADLTEGLED

Target ORF information:

RefSeq Version	NM_020315.5
Organism	Homo sapiens(human)
Definition	Homo sapiens pyridoxal phosphatase (PDXP), mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_020315.5

ORF Insert Sequence:

ATGGCGCGCT GCGAGAGGCT GCGCGGAGCG GCCCTGCGCG ACGTGCTGGG CCGGGCGCAG 
GGGGTCCTGT TCGACTGTGA CGGGGTGCTG TGGAACGGCG AGCGCGCCGT GCCGGGCGCC 
CCGGAGCTGC TGGAGCGGCT GGCGCGGGCC GGCAAGGCGG CTCTGTTTGT GAGCAACAAC 
AGCCGGCGCG CGCGGCCCGA GCTGGCCCTG CGCTTCGCGC GCCTCGGCTT CGGGGGGCTG 
CGCGCCGAGC AGCTCTTCAG CTCCGCGCTG TGCGCCGCGC GCCTGCTGCG CCAGCGCCTG 
CCCGGGCCTC CGGACGCGCC GGGCGCCGTG TTCGTGCTGG GCGGCGAGGG GCTGCGCGCC 
GAGCTGCGCG CCGCGGGGCT GCGCCTGGCC GGGGACCCGA GCGCGGGGGA CGGCGCGGCC 
CCGCGCGTGC GCGCCGTGCT TGTGGGCTAC GACGAGCACT TCTCCTTCGC CAAGCTGAGG 
GAGGCGTGCG CGCACCTGCG CGACCCCGAG TGCCTACTCG TGGCCACCGA CCGTGACCCA 
TGGCACCCGC TGAGCGACGG CAGCCGGACC CCTGGCACCG GGAGCCTGGC CGCTGCAGTG 
GAGACAGCCT CGGGACGCCA GGCCCTGGTG GTGGGCAAGC CCAGCCCCTA CATGTTCGAG 
TGCATCACGG AGAACTTCAG CATCGACCCC GCACGCACGC TTATGGTGGG TGACCGCCTG 
GAGACCGACA TCCTCTTTGG CCACCGCTGC GGCATGACCA CTGTGCTCAC GCTCACAGGA 
GTCTCCCGCC TAGAAGAGGC CCAGGCCTAC CTAGCGGCCG GCCAGCACGA CCTCGTGCCC 
CATTACTATG TGGAGAGCAT CGCAGACTTG ACAGAGGGGT TGGAGGACTG A

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

PDXP ( NM_020315.4 ) cDNA ORF clone, Homo sapiens(human) -> NP_064711.1 Homo sapiens pyridoxal phosphatase (PDXP), mRNA.

Price & Availability↑

CloneID	OHu30342
Clone ID Related Accession (Same CDS sequence)	NM_020315.5 , NM_020315.4
Accession Version	NM_020315.4	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 891bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2017-12-26
Organism	Homo sapiens(human)
Product	pyridoxal phosphate phosphatase
Comment	Comment: VALIDATED REFSEQ: This record has undergone validation or preliminary review. The reference sequence was derived from BC064922.1. On Jan 27, 2006 this sequence version replaced NM_020315.3. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: BC064922.1, HM005576.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA1965299, SAMEA1966682 [ECO:0000348] ##Evidence-Data-END## COMPLETENESS: complete on the 3' end.

ATGGCGCGCT GCGAGAGGCT GCGCGGAGCG GCCCTGCGCG ACGTGCTGGG CCGGGCGCAG 
GGGGTCCTGT TCGACTGTGA CGGGGTGCTG TGGAACGGCG AGCGCGCCGT GCCGGGCGCC 
CCGGAGCTGC TGGAGCGGCT GGCGCGGGCC GGCAAGGCGG CTCTGTTTGT GAGCAACAAC 
AGCCGGCGCG CGCGGCCCGA GCTGGCCCTG CGCTTCGCGC GCCTCGGCTT CGGGGGGCTG 
CGCGCCGAGC AGCTCTTCAG CTCCGCGCTG TGCGCCGCGC GCCTGCTGCG CCAGCGCCTG 
CCCGGGCCTC CGGACGCGCC GGGCGCCGTG TTCGTGCTGG GCGGCGAGGG GCTGCGCGCC 
GAGCTGCGCG CCGCGGGGCT GCGCCTGGCC GGGGACCCGA GCGCGGGGGA CGGCGCGGCC 
CCGCGCGTGC GCGCCGTGCT TGTGGGCTAC GACGAGCACT TCTCCTTCGC CAAGCTGAGG 
GAGGCGTGCG CGCACCTGCG CGACCCCGAG TGCCTACTCG TGGCCACCGA CCGTGACCCA 
TGGCACCCGC TGAGCGACGG CAGCCGGACC CCTGGCACCG GGAGCCTGGC CGCTGCAGTG 
GAGACAGCCT CGGGACGCCA GGCCCTGGTG GTGGGCAAGC CCAGCCCCTA CATGTTCGAG 
TGCATCACGG AGAACTTCAG CATCGACCCC GCACGCACGC TTATGGTGGG TGACCGCCTG 
GAGACCGACA TCCTCTTTGG CCACCGCTGC GGCATGACCA CTGTGCTCAC GCTCACAGGA 
GTCTCCCGCC TAGAAGAGGC CCAGGCCTAC CTAGCGGCCG GCCAGCACGA CCTCGTGCCC 
CATTACTATG TGGAGAGCAT CGCAGACTTG ACAGAGGGGT TGGAGGACTG A

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_064711.1
CDS	54..944
Translation	MARCERLRGAALRDVLGRAQGVLFDCDGVLWNGERAVPGAPELLERLARAGKAALFVSNNSRRARPELALRFARLGFGGLRAEQLFSSALCAARLLRQRLPGPPDAPGAVFVLGGEGLRAELRAAGLRLAGDPSAGDGAAPRVRAVLVGYDEHFSFAKLREACAHLRDPECLLVATDRDPWHPLSDGSRTPGTGSLAAAVETASGRQALVVGKPSPYMFECITENFSIDPARTLMVGDRLETDILFGHRCGMTTVLTLTGVSRLEEAQAYLAAGQHDLVPHYYVESIADLTEGLED

Target ORF information:

RefSeq Version	NM_020315.4
Organism	Homo sapiens(human)
Definition	Homo sapiens pyridoxal phosphatase (PDXP), mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_020315.4

ORF Insert Sequence:

ATGGCGCGCT GCGAGAGGCT GCGCGGAGCG GCCCTGCGCG ACGTGCTGGG CCGGGCGCAG 
GGGGTCCTGT TCGACTGTGA CGGGGTGCTG TGGAACGGCG AGCGCGCCGT GCCGGGCGCC 
CCGGAGCTGC TGGAGCGGCT GGCGCGGGCC GGCAAGGCGG CTCTGTTTGT GAGCAACAAC 
AGCCGGCGCG CGCGGCCCGA GCTGGCCCTG CGCTTCGCGC GCCTCGGCTT CGGGGGGCTG 
CGCGCCGAGC AGCTCTTCAG CTCCGCGCTG TGCGCCGCGC GCCTGCTGCG CCAGCGCCTG 
CCCGGGCCTC CGGACGCGCC GGGCGCCGTG TTCGTGCTGG GCGGCGAGGG GCTGCGCGCC 
GAGCTGCGCG CCGCGGGGCT GCGCCTGGCC GGGGACCCGA GCGCGGGGGA CGGCGCGGCC 
CCGCGCGTGC GCGCCGTGCT TGTGGGCTAC GACGAGCACT TCTCCTTCGC CAAGCTGAGG 
GAGGCGTGCG CGCACCTGCG CGACCCCGAG TGCCTACTCG TGGCCACCGA CCGTGACCCA 
TGGCACCCGC TGAGCGACGG CAGCCGGACC CCTGGCACCG GGAGCCTGGC CGCTGCAGTG 
GAGACAGCCT CGGGACGCCA GGCCCTGGTG GTGGGCAAGC CCAGCCCCTA CATGTTCGAG 
TGCATCACGG AGAACTTCAG CATCGACCCC GCACGCACGC TTATGGTGGG TGACCGCCTG 
GAGACCGACA TCCTCTTTGG CCACCGCTGC GGCATGACCA CTGTGCTCAC GCTCACAGGA 
GTCTCCCGCC TAGAAGAGGC CCAGGCCTAC CTAGCGGCCG GCCAGCACGA CCTCGTGCCC 
CATTACTATG TGGAGAGCAT CGCAGACTTG ACAGAGGGGT TGGAGGACTG A

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

PubMed

Chronophin coordinates cell leading edge dynamics by controlling active cofilin levels.
Proceedings of the National Academy of Sciences of the United States of America112(37)E5150-9(2015 Sep)
Delorme-Walker V,Seo JY,Gohla A,Fowler B,Bohl B,DerMardirossian C

A novel Rac1 GAP splice variant relays poly-Ub accumulation signals to mediate Rac1 inactivation.
Molecular biology of the cell24(3)194-209(2013 Feb)
Huang TY,Michael S,Xu T,Sarkeshik A,Moresco JJ,Yates JR 3rd,Masliah E,Bokoch GM,DerMardirossian C

Genes linked to energy metabolism and immunoregulatory mechanisms are associated with subcutaneous adipose tissue distribution in HIV-infected men.
Pharmacogenetics and genomics21(12)798-807(2011 Dec)
Irvin MR,Shrestha S,Chen YD,Wiener HW,Haritunians T,Vaughan LK,Tiwari HK,Taylor KD,Scherzer R,Saag MS,Grunfeld C,Rotter JI,Arnett DK

Chronophin mediates an ATP-sensing mechanism for cofilin dephosphorylation and neuronal cofilin-actin rod formation.
Developmental cell15(5)691-703(2008 Nov)
Huang TY,Minamide LS,Bamburg JR,Bokoch GM

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PDXP cDNA ORF clone, Homo sapiens(human)

Gene

Clones

gRNAs

Related articles in PubMed

Target ORF information:

Target ORF information:

ORF Insert Sequence:

Target ORF information:

Target ORF information:

ORF Insert Sequence:

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