PSMC3 cDNA ORF clone, Homo sapiens(human)

Gene
Clones
gRNAs

Summary

Gene Symbol	PSMC3
Entrez Gene ID	5702
Full Name	proteasome 26S subunit, ATPase 3
Synonyms	TBP1
General protein information	Preferred Names proteasome 26S subunit, ATPase 3 Names 26S proteasome regulatory subunit 6A 26S protease regulatory subunit 6A 26S proteasome AAA-ATPase subunit RPT5 TBP-1 Tat-binding protein 1 human immunodeficiency virus tat transactivator binding protein-1 proteasome (prosome, macropain) 26S subunit, ATPase, 3 proteasome subunit P50 testicular secretory protein Li 42
Gene Type	protein-coding
Organism	Homo sapiens(human)
Genome	Chromosome: 11 Map Location: 11p11.2
Summary	The 26S proteasome is a multicatalytic proteinase complex with a highly ordered structure composed of 2 complexes, a 20S core and a 19S regulator. The 20S core is composed of 4 rings of 28 non-identical subunits; 2 rings are composed of 7 alpha subunits and 2 rings are composed of 7 beta subunits. The 19S regulator is composed of a base, which contains 6 ATPase subunits and 2 non-ATPase subunits, and a lid, which contains up to 10 non-ATPase subunits. Proteasomes are distributed throughout eukaryotic cells at a high concentration and cleave peptides in an ATP/ubiquitin-dependent process in a non-lysosomal pathway. An essential function of a modified proteasome, the immunoproteasome, is the processing of class I MHC peptides. This gene encodes one of the ATPase subunits, a member of the triple-A family of ATPases that have chaperone-like activity. This subunit may compete with PSMC2 for binding to the HIV tat protein to regulate the interaction between the viral protein and the transcription complex. A pseudogene has been identified on chromosome 9. [provided by RefSeq, Jul 2008].
Disorder MIM:	186852

mRNA and Protein(s)

mRNA	Protein	Name
XM_017018026.1	XP_016873515.1	26S proteasome regulatory subunit 6A isoform X1
NM_002804.4	NP_002795.2	26S proteasome regulatory subunit 6A

Pathways from BioSystems

Homologies

Canis lupus familiaris (dog)	PSMC3	XP_533187.3
Bos taurus (cattle)	PSMC3	NP_001179113.2
Mus musculus (house mouse)	Psmc3	NP_032974.2
Caenorhabditis elegans (roundworm)	rpt-5	NP_491672.1
Eremothecium gossypii	AGOS_AER254W	NP_985111.2
Oryza sativa (rice)	Os06g0173100	NP_001056944.1
Homo sapiens (human)	PSMC3	NP_002795.2
Anopheles gambiae (African malaria mosquito)	AgaP_AGAP000616	XP_310465.3
Arabidopsis thaliana (thale cress)	RPT5A	NP_187204.1
Saccharomyces cerevisiae (baker's yeast)	RPT5	NP_014760.3
Magnaporthe oryzae (rice blast fungus)	MGG_12925	XP_003712713.1
Oryza sativa (rice)	Os02g0803700	NP_001048428.1
Pan troglodytes (chimpanzee)	PSMC3	XP_508413.3
	PSMC3	XP_001106497.1
Rattus norvegicus (Norway rat)	Psmc3	NP_113783.1
Gallus gallus (chicken)	PSMC3	NP_001026361.1
Drosophila melanogaster (fruit fly)	Tbp-1	NP_524464.1
Danio rerio (zebrafish)	psmc3	NP_001002064.1
Kluyveromyces lactis	KLLA0E21209g	XP_454909.1
Schizosaccharomyces pombe (fission yeast)	rpt5	XP_001713083.1
Neurospora crassa	NCU04414	XP_957491.2
Arabidopsis thaliana (thale cress)	RPT5B	NP_172384.1
Xenopus tropicalis (tropical clawed frog)	psmc3	NP_001006786.1

Gene Ontology
Bibliography

Related articles in PubMed

Architecture of the human interactome defines protein communities and disease networks.
Huttlin EL, Bruckner RJ, Paulo JA, Cannon JR, Ting L, Baltier K, Colby G, Gebreab F, Gygi MP, Parzen H, Szpyt J, Tam S, Zarraga G, Pontano-Vaites L, Swarup S, White AE, Schweppe DK, Rad R, Erickson BK, Obar RA, Guruharsha KG, Li K, Artavanis-Tsakonas S, Gygi SP, Harper JW
Nature545(7655)505-509(2017 05)

Protein interaction network of the mammalian Hippo pathway reveals mechanisms of kinase-phosphatase interactions.
Couzens AL, Knight JD, Kean MJ, Teo G, Weiss A, Dunham WH, Lin ZY, Bagshaw RD, Sicheri F, Pawson T, Wrana JL, Choi H, Gingras AC
Science signaling6(302)rs15(2013 Nov)

Genome-wide meta-analysis identifies 11 new loci for anthropometric traits and provides insights into genetic architecture.
Berndt SI, Gustafsson S, M?gi R, Ganna A, Wheeler E, Feitosa MF, Justice AE, Monda KL, Croteau-Chonka DC, Day FR, Esko T, Fall T, Ferreira T, Gentilini D, Jackson AU, Luan J, Randall JC, Vedantam S, Willer CJ, Winkler TW, Wood AR, Workalemahu T, Hu YJ, Lee SH, Liang L, Lin DY, Min JL, Neale BM, Thorleifsson G, Yang J, Albrecht E, Amin N, Bragg-Gresham JL, Cadby G, den Heijer M, Eklund N, Fischer K, Goel A, Hottenga JJ, Huffman JE, Jarick I, Johansson ?, Johnson T, Kanoni S, Kleber ME, K?nig IR, Kristiansson K, Kutalik Z, Lamina C, Lecoeur C, Li G, Mangino M, McArdle WL, Medina-Gomez C, M?ller-Nurasyid M, Ngwa JS, Nolte IM, Paternoster L, Pechlivanis S, Perola M, Peters MJ, Preuss M, Rose LM, Shi J, Shungin D, Smith AV, Strawbridge RJ, Surakka I, Teumer A, Trip MD, Tyrer J, Van Vliet-Ostaptchouk JV, Vandenput L, Waite LL, Zhao JH, Absher D, Asselbergs FW, Atalay M, Attwood AP, Balmforth AJ, Basart H, Beilby J, Bonnycastle LL, Brambilla P, Bruinenberg M, Campbell H, Chasman DI, Chines PS, Collins FS, Connell JM, Cookson WO, de Faire U, de Vegt F, Dei M, Dimitriou M, Edkins S, Estrada K, Evans DM, Farrall M, Ferrario MM, Ferri?res J, Franke L, Frau F, Gejman PV, Grallert H, Gr?nberg H, Gudnason V, Hall AS, Hall P, Hartikainen AL, Hayward C, Heard-Costa NL, Heath AC, Hebebrand J, Homuth G, Hu FB, Hunt SE, Hypp?nen E, Iribarren C, Jacobs KB, Jansson JO, Jula A, K?h?nen M, Kathiresan S, Kee F, Khaw KT, Kivim?ki M, Koenig W, Kraja AT, Kumari M, Kuulasmaa K, Kuusisto J, Laitinen JH, Lakka TA, Langenberg C, Launer LJ, Lind L, Lindstr?m J, Liu J, Liuzzi A, Lokki ML, Lorentzon M, Madden PA, Magnusson PK, Manunta P, Marek D, M?rz W, Mateo Leach I, McKnight B, Medland SE, Mihailov E, Milani L, Montgomery GW, Mooser V, M?hleisen TW, Munroe PB, Musk AW, Narisu N, Navis G, Nicholson G, Nohr EA, Ong KK, Oostra BA, Palmer CN, Palotie A, Peden JF, Pedersen N, Peters A, Polasek O, Pouta A, Pramstaller PP, Prokopenko I, P?tter C, Radhakrishnan A, Raitakari O, Rendon A, Rivadeneira F, Rudan I, Saaristo TE, Sambrook JG, Sanders AR, Sanna S, Saramies J, Schipf S, Schreiber S, Schunkert H, Shin SY, Signorini S, Sinisalo J, Skrobek B, Soranzo N, Stan??kov? A, Stark K, Stephens JC, Stirrups K, Stolk RP, Stumvoll M, Swift AJ, Theodoraki EV, Thorand B, Tregouet DA, Tremoli E, Van der Klauw MM, van Meurs JB, Vermeulen SH, Viikari J, Virtamo J, Vitart V, Waeber G, Wang Z, Wid?n E, Wild SH, Willemsen G, Winkelmann BR, Witteman JC, Wolffenbuttel BH, Wong A, Wright AF, Zillikens MC, Amouyel P, Boehm BO, Boerwinkle E, Boomsma DI, Caulfield MJ, Chanock SJ, Cupples LA, Cusi D, Dedoussis GV, Erdmann J, Eriksson JG, Franks PW, Froguel P, Gieger C, Gyllensten U, Hamsten A, Harris TB, Hengstenberg C, Hicks AA, Hingorani A, Hinney A, Hofman A, Hovingh KG, Hveem K, Illig T, Jarvelin MR, J?ckel KH, Keinanen-Kiukaanniemi SM, Kiemeney LA, Kuh D, Laakso M, Lehtim?ki T, Levinson DF, Martin NG, Metspalu A, Morris AD, Nieminen MS, Nj?lstad I, Ohlsson C, Oldehinkel AJ, Ouwehand WH, Palmer LJ, Penninx B, Power C, Province MA, Psaty BM, Qi L, Rauramaa R, Ridker PM, Ripatti S, Salomaa V, Samani NJ, Snieder H, S?rensen TI, Spector TD, Stefansson K, T?njes A, Tuomilehto J, Uitterlinden AG, Uusitupa M, van der Harst P, Vollenweider P, Wallaschofski H, Wareham NJ, Watkins H, Wichmann HE, Wilson JF, Abecasis GR, Assimes TL, Barroso I, Boehnke M, Borecki IB, Deloukas P, Fox CS, Frayling T, Groop LC, Haritunian T, Heid IM, Hunter D, Kaplan RC, Karpe F, Moffatt MF, Mohlke KL, O'Connell JR, Pawitan Y, Schadt EE, Schlessinger D, Steinthorsdottir V, Strachan DP, Thorsteinsdottir U, van Duijn CM, Visscher PM, Di Blasio AM, Hirschhorn JN, Lindgren CM, Morris AP, Meyre D, Scherag A, McCarthy MI, Speliotes EK, North KE, Loos RJ, Ingelsson E
Nature genetics45(5)501-12(2013 May)

Discovery and fine mapping of serum protein loci through transethnic meta-analysis.
Franceschini N, van Rooij FJ, Prins BP, Feitosa MF, Karakas M, Eckfeldt JH, Folsom AR, Kopp J, Vaez A, Andrews JS, Baumert J, Boraska V, Broer L, Hayward C, Ngwa JS, Okada Y, Polasek O, Westra HJ, Wang YA, Del Greco M F, Glazer NL, Kapur K, Kema IP, Lopez LM, Schillert A, Smith AV, Winkler CA, Zgaga L, , Bandinelli S, Bergmann S, Boban M, Bochud M, Chen YD, Davies G, Dehghan A, Ding J, Doering A, Durda JP, Ferrucci L, Franco OH, Franke L, Gunjaca G, Hofman A, Hsu FC, Kolcic I, Kraja A, Kubo M, Lackner KJ, Launer L, Loehr LR, Li G, Meisinger C, Nakamura Y, Schwienbacher C, Starr JM, Takahashi A, Torlak V, Uitterlinden AG, Vitart V, Waldenberger M, Wild PS, Kirin M, Zeller T, Zemunik T, Zhang Q, Ziegler A, Blankenberg S, Boerwinkle E, Borecki IB, Campbell H, Deary IJ, Frayling TM, Gieger C, Harris TB, Hicks AA, Koenig W, O' Donnell CJ, Fox CS, Pramstaller PP, Psaty BM, Reiner AP, Rotter JI, Rudan I, Snieder H, Tanaka T, van Duijn CM, Vollenweider P, Waeber G, Wilson JF, Witteman JC, Wolffenbuttel BH, Wright AF, Wu Q, Liu Y, Jenny NS, North KE, Felix JF, Alizadeh BZ, Cupples LA, Perry JR, Morris AP
American journal of human genetics91(4)744-53(2012 Oct)

GeneRIFs: Gene References Into Functions What's a GeneRIF?

These data suggest the existence of a negative feedback loop involving Akt/PKB that might act as a sensor to modulate TBP-1 levels in proliferating cells.
Title: A regulatory mechanism involving TBP-1/Tat-Binding Protein 1 and Akt/PKB in the control of cell proliferation.

19S ATPase S6b (S6'/TBP1) binds CIITApIV in an S6a-dependent fashion and has effects similar to S6a on CIITApIV histone acetylation.
Title: The 19S ATPase S6a (S6'/TBP1) regulates the transcription initiation of class II transactivator.

findings suggest that a component of 19S regulatory particles directly binds AR and might participate in AR-mediated transcriptional activation in cooperation with TBPIP.
Title: Tat-binding protein-1 (TBP-1), an ATPase of 19S regulatory particles of the 26S proteasome, enhances androgen receptor function in cooperation with TBP-1-interacting protein/Hop2.

The stabilization effect exerted by TBP-1 requires an intact N-terminal 39 amino acids in ARF and occurs independently from N-terminal ubiquitination of the protein.
Title: TBP-1 protects the human oncosuppressor p14ARF from proteasomal degradation.

Heplipin induced KG-1 cell apoptosis is related with Wntl3 and ATPase3.
Title: [Identification of heplipin inducing apoptosis-related genes in KG-1 human leukemia cells by differential display RT-PCR].

The following PSMC3 gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the PSMC3 cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1⁺/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.

***CloneID	Accession No.	Definition	**Vector	*Turnaround time	Price (USD)	Select
OHu17410	NM_002804.4 Latest version!	Homo sapiens proteasome 26S subunit, ATPase 3 (PSMC3), mRNA.	pcDNA3.1-C-(k)DYK or customized vector	in pcDNA3.1-C-(k)DYK	$189.50-$265.30 $379.00
OHu92378	XM_017018026.1 Latest version!	Homo sapiens proteasome 26S subunit, ATPase 3 (PSMC3), transcript variant X1, mRNA.	pcDNA3.1-C-(k)DYK or customized vector	9-11	$223.30 $319.00

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** GenScript guarantees 100% sequence accuracy of all synthetic DNA constructs we deliver, but we do not guarantee protein expression in your experimental system. Protein expression is influenced by many factors that may vary between experiments or laboratories. In addition, please pay attention to the signal peptide, propeptide and transit peptide in target ORF, which may affect the choice of vector (N/C terminal tag vector).

***One clone ID might be correlated to multiple accession numbers, which share the same CDS sequence.

Reference Sequences (Refseq)

PSMC3 ( NM_002804.4 ) cDNA ORF clone, Homo sapiens(human) -> NP_002795.2 Homo sapiens proteasome 26S subunit, ATPase 3 (PSMC3), mRNA.

Price & Availability↑

CloneID	OHu17410
Clone ID Related Accession (Same CDS sequence)	NM_002804.4
Accession Version	NM_002804.4 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 1320bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-12-24
Organism	Homo sapiens(human)
Product	26S proteasome regulatory subunit 6A
Comment	Comment: REVIEWED REFSEQ: This record has been curated by NCBI staff. The reference sequence was derived from BP284685.1 and BC008713.2. On Mar 22, 2007 this sequence version replaced NM_002804.3. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: HM005582.1, SRR1163655.308870.1 [ECO:0000332] RNAseq introns :: mixed/partial sample support SAMEA1965299, SAMEA1966682 [ECO:0000350] ##Evidence-Data-END## ##RefSeq-Attributes-START## RefSeq Select criteria :: based on conservation, expression ##RefSeq-Attributes-END## COMPLETENESS: complete on the 3' end.

ATGAATCTGC TGCCGAATAT TGAGAGTCCA GTGACTCGGC AGGAGAAGAT GGCGACCGTG 
TGGGATGAGG CCGAGCAAGA TGGAATTGGG GAGGAGGTGC TCAAGATGTC CACGGAGGAG 
ATCATCCAGC GCACACGGCT GCTGGACAGT GAGATCAAGA TCATGAAGAG TGAAGTGTTG 
AGAGTCACCC ATGAGCTCCA AGCCATGAAG GACAAGATAA AAGAGAACAG TGAGAAAATC 
AAAGTGAACA AGACCCTGCC GTACCTTGTC TCCAACGTCA TCGAGCTCCT GGATGTTGAT 
CCTAATGACC AAGAGGAGGA TGGTGCCAAT ATTGACCTGG ACTCCCAGAG GAAGGGCAAG 
TGTGCTGTGA TCAAAACCTC TACACGACAG ACGTACTTCC TTCCTGTGAT TGGGTTGGTG 
GATGCTGAAA AGCTAAAGCC AGGAGACCTG GTGGGTGTGA ACAAAGACTC CTATCTGATC 
CTGGAGACGC TGCCCACAGA GTATGACTCG CGGGTGAAGG CCATGGAGGT AGACGAGAGG 
CCCACGGAGC AATACAGTGA CATTGGGGGT TTGGACAAGC AGATCCAGGA GCTGGTGGAG 
GCCATTGTCT TGCCAATGAA CCACAAGGAG AAGTTTGAGA ACTTGGGGAT CCAACCTCCA 
AAAGGGGTGC TGATGTATGG GCCCCCAGGG ACGGGGAAGA CCCTCCTGGC CCGGGCCTGT 
GCCGCACAGA CTAAGGCCAC CTTCCTAAAG CTGGCTGGCC CCCAGCTGGT GCAGATGTTC 
ATTGGAGATG GTGCCAAGCT AGTCCGGGAT GCCTTTGCCC TGGCCAAGGA GAAAGCGCCC 
TCTATCATCT TCATTGATGA GTTGGATGCC ATCGGCACCA AGCGCTTTGA CAGTGAGAAG 
GCTGGGGACC GGGAGGTGCA GAGGACAATG CTGGAGCTTC TGAACCAGCT GGATGGCTTC 
CAGCCCAACA CCCAAGTTAA GGTAATTGCA GCCACAAACA GGGTGGACAT CCTGGACCCC 
GCCCTCCTCC GCTCGGGCCG CCTTGACCGC AAGATAGAGT TCCCGATGCC CAATGAGGAG 
GCCCGGGCCA GAATCATGCA GATCCACTCC CGAAAGATGA ATGTCAGTCC TGACGTGAAC 
TACGAGGAGC TGGCCCGCTG CACAGATGAC TTCAATGGGG CCCAGTGCAA GGCTGTGTGT 
GTGGAGGCGG GCATGATCGC ACTGCGCAGG GGTGCCACGG AGCTCACCCA CGAGGACTAC 
ATGGAAGGCA TCCTGGAGGT GCAGGCCAAG AAGAAAGCCA ACCTACAATA CTACGCCTAG

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_002795.2
CDS	195..1514
Translation	MNLLPNIESPVTRQEKMATVWDEAEQDGIGEEVLKMSTEEIIQRTRLLDSEIKIMKSEVLRVTHELQAMKDKIKENSEKIKVNKTLPYLVSNVIELLDVDPNDQEEDGANIDLDSQRKGKCAVIKTSTRQTYFLPVIGLVDAEKLKPGDLVGVNKDSYLILETLPTEYDSRVKAMEVDERPTEQYSDIGGLDKQIQELVEAIVLPMNHKEKFENLGIQPPKGVLMYGPPGTGKTLLARACAAQTKATFLKLAGPQLVQMFIGDGAKLVRDAFALAKEKAPSIIFIDELDAIGTKRFDSEKAGDREVQRTMLELLNQLDGFQPNTQVKVIAATNRVDILDPALLRSGRLDRKIEFPMPNEEARARIMQIHSRKMNVSPDVNYEELARCTDDFNGAQCKAVCVEAGMIALRRGATELTHEDYMEGILEVQAKKKANLQYYA

Target ORF information:

RefSeq Version	NM_002804.4
Organism	Homo sapiens(human)
Definition	Homo sapiens proteasome 26S subunit, ATPase 3 (PSMC3), mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_002804.4

ORF Insert Sequence:

ATGAATCTGC TGCCGAATAT TGAGAGTCCA GTGACTCGGC AGGAGAAGAT GGCGACCGTG 
TGGGATGAGG CCGAGCAAGA TGGAATTGGG GAGGAGGTGC TCAAGATGTC CACGGAGGAG 
ATCATCCAGC GCACACGGCT GCTGGACAGT GAGATCAAGA TCATGAAGAG TGAAGTGTTG 
AGAGTCACCC ATGAGCTCCA AGCCATGAAG GACAAGATAA AAGAGAACAG TGAGAAAATC 
AAAGTGAACA AGACCCTGCC GTACCTTGTC TCCAACGTCA TCGAGCTCCT GGATGTTGAT 
CCTAATGACC AAGAGGAGGA TGGTGCCAAT ATTGACCTGG ACTCCCAGAG GAAGGGCAAG 
TGTGCTGTGA TCAAAACCTC TACACGACAG ACGTACTTCC TTCCTGTGAT TGGGTTGGTG 
GATGCTGAAA AGCTAAAGCC AGGAGACCTG GTGGGTGTGA ACAAAGACTC CTATCTGATC 
CTGGAGACGC TGCCCACAGA GTATGACTCG CGGGTGAAGG CCATGGAGGT AGACGAGAGG 
CCCACGGAGC AATACAGTGA CATTGGGGGT TTGGACAAGC AGATCCAGGA GCTGGTGGAG 
GCCATTGTCT TGCCAATGAA CCACAAGGAG AAGTTTGAGA ACTTGGGGAT CCAACCTCCA 
AAAGGGGTGC TGATGTATGG GCCCCCAGGG ACGGGGAAGA CCCTCCTGGC CCGGGCCTGT 
GCCGCACAGA CTAAGGCCAC CTTCCTAAAG CTGGCTGGCC CCCAGCTGGT GCAGATGTTC 
ATTGGAGATG GTGCCAAGCT AGTCCGGGAT GCCTTTGCCC TGGCCAAGGA GAAAGCGCCC 
TCTATCATCT TCATTGATGA GTTGGATGCC ATCGGCACCA AGCGCTTTGA CAGTGAGAAG 
GCTGGGGACC GGGAGGTGCA GAGGACAATG CTGGAGCTTC TGAACCAGCT GGATGGCTTC 
CAGCCCAACA CCCAAGTTAA GGTAATTGCA GCCACAAACA GGGTGGACAT CCTGGACCCC 
GCCCTCCTCC GCTCGGGCCG CCTTGACCGC AAGATAGAGT TCCCGATGCC CAATGAGGAG 
GCCCGGGCCA GAATCATGCA GATCCACTCC CGAAAGATGA ATGTCAGTCC TGACGTGAAC 
TACGAGGAGC TGGCCCGCTG CACAGATGAC TTCAATGGGG CCCAGTGCAA GGCTGTGTGT 
GTGGAGGCGG GCATGATCGC ACTGCGCAGG GGTGCCACGG AGCTCACCCA CGAGGACTAC 
ATGGAAGGCA TCCTGGAGGT GCAGGCCAAG AAGAAAGCCA ACCTACAATA CTACGCCTAG

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

PSMC3 ( XM_017018026.1 ) cDNA ORF clone, Homo sapiens(human) -> XP_016873515.1 Homo sapiens proteasome 26S subunit, ATPase 3 (PSMC3), transcript variant X1, mRNA.

Price & Availability↑

CloneID	OHu92378
Clone ID Related Accession (Same CDS sequence)	XM_017018026.1
Accession Version	XM_017018026.1 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 1386bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-12-05
Organism	Homo sapiens(human)
Product	26S proteasome regulatory subunit 6A isoform X1
Comment	Comment: MODEL REFSEQ: This record is predicted by automated computational analysis. This record is derived from a genomic sequence (NC_000011.10) annotated using gene prediction method: Gnomon, supported by EST evidence. Also see: Documentation of NCBI's Annotation Process ##Genome-Annotation-Data-START## Annotation Provider :: NCBI Annotation Status :: Updated annotation Annotation Name :: Homo sapiens Updated Annotation Release 109.20191205 Annotation Version :: 109.20191205 Annotation Pipeline :: NCBI eukaryotic genome annotation pipeline Annotation Software Version :: 8.3 Annotation Method :: Best-placed RefSeq; propagated RefSeq model Features Annotated :: Gene; mRNA; CDS; ncRNA ##Genome-Annotation-Data-END##

ATGAATCTGC TGCCGAATAT TGAGAGTCCA GTGACTCGGC AGGAGAAGAT GGCGACCGTG 
TGGGATGAGG CCGAGCAAGA TGGAATTGGG GAGGAGGTGC TCAAGATGTC CACGGAGGAG 
ATCATCCAGC GCACACGGCT GCTGGACAGT GAGATCAAGA TCATGAAGAG TGAAGTGTTG 
AGAGTCACCC ATGAGCTCCA AGCCATGAAG GACAAGATAA AAGAGAACAG TGAGAAAATC 
AAAGTGAACA AGACCCTGCC GTACCTTGTC TCCAACGTCA TCGAGCTCCT GGATGTTGAT 
CCTAATGACC AAGAGGAGGA TGGTGCCAAT ATTGACCTGG ACTCCCAGAG GAAGGGCAAG 
TGTGCTGTGA TCAAAACCTC TACACGACAG ACGTACTTCC TTCCTGTGAT TGGGTTGGTG 
GATGCTGAAA AGCTAAAGCC AGGAGACCTG GTGGGTGTGA ACAAAGACTC CTATCTGATC 
CTGGAGACGC TGCCCACAGA GTATGACTCG CGGGTGAAGG CCATGGAGGT AGACGAGAGG 
CCCACGGAGC AATACAGTGA CATTGGGGGT TTGGACAAGC AGATCCAGGA GCTGGTGGAG 
GCCATTGTCT TGCCAATGAA CCACAAGGAG AAGTTTGAGA ACTTGGGGAT CCAACCTCCA 
AAAGGGGTGC TGATGTATGG GCCCCCAGGG ACGGGGAAGA CCCTCCTGGC CCGGGCCTGT 
GCCGCACAGA CTAAGGCCAC CTTCCTAAAG CTGGCTGGCC CCCAGCTGGT GCAGATGTTC 
ATTGGAGATG GTGCCAAGCT AGTCCGGGAT GCCTTTGCCC TGGCCAAGGA GAAAGCGCCC 
TCTATCATCT TCATTGATGA GTTGGATGCC ATCGGCACCA AGCGCTTTGA CAGTGAGAAG 
GCTGGGGACC GGGAGGTGCA GAGGACAATG CTGGAGCTTC TGAACCAGCT GGATGGCTTC 
CAGCCCAACA CCCAAGTTAA GGTAATTGCA GCCACAAACA GGGTGGACAT CCTGGACCCC 
GCCCTCCTCC GCTCGGGCCG CCTTGACCGC AAGATAGAGT TCCCGATGCC CAATGAGGAG 
GCCCGGGCCA GAATCATGCA GATCCACTCC CGAAAGATGA ATGTCAGTCC TGACGTGAAC 
TACGAGGAGC TGGCCCGCTG CACAGATGAC TTCAATGGGG CCCAGTGCAA GGCTGTGTGT 
GTGGAGGCGG TGAGTGGTCA GCTGGGGTGG GTGCGTTGCT TTGTGCCTTC TTGCCCCCTC 
CCTGGACAGG ATGGGGGCAT TTGGCTGGTG GAGACGGCTG AGGGAAGAGG CCTGAGCCTC 
AGGGAGCCAG GGAAGGCATT CAGGCGTTCA GACCTAGACT CTGTTTGTCC CGGCTGTAGG 
GCATGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	XP_016873515.1
CDS	195..1580
Translation	MNLLPNIESPVTRQEKMATVWDEAEQDGIGEEVLKMSTEEIIQRTRLLDSEIKIMKSEVLRVTHELQAMKDKIKENSEKIKVNKTLPYLVSNVIELLDVDPNDQEEDGANIDLDSQRKGKCAVIKTSTRQTYFLPVIGLVDAEKLKPGDLVGVNKDSYLILETLPTEYDSRVKAMEVDERPTEQYSDIGGLDKQIQELVEAIVLPMNHKEKFENLGIQPPKGVLMYGPPGTGKTLLARACAAQTKATFLKLAGPQLVQMFIGDGAKLVRDAFALAKEKAPSIIFIDELDAIGTKRFDSEKAGDREVQRTMLELLNQLDGFQPNTQVKVIAATNRVDILDPALLRSGRLDRKIEFPMPNEEARARIMQIHSRKMNVSPDVNYEELARCTDDFNGAQCKAVCVEAVSGQLGWVRCFVPSCPLPGQDGGIWLVETAEGRGLSLREPGKAFRRSDLDSVCPGCRA

Target ORF information:

RefSeq Version	XM_017018026.1
Organism	Homo sapiens(human)
Definition	Homo sapiens proteasome 26S subunit, ATPase 3 (PSMC3), transcript variant X1, mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

XM_017018026.1

ORF Insert Sequence:

ATGAATCTGC TGCCGAATAT TGAGAGTCCA GTGACTCGGC AGGAGAAGAT GGCGACCGTG 
TGGGATGAGG CCGAGCAAGA TGGAATTGGG GAGGAGGTGC TCAAGATGTC CACGGAGGAG 
ATCATCCAGC GCACACGGCT GCTGGACAGT GAGATCAAGA TCATGAAGAG TGAAGTGTTG 
AGAGTCACCC ATGAGCTCCA AGCCATGAAG GACAAGATAA AAGAGAACAG TGAGAAAATC 
AAAGTGAACA AGACCCTGCC GTACCTTGTC TCCAACGTCA TCGAGCTCCT GGATGTTGAT 
CCTAATGACC AAGAGGAGGA TGGTGCCAAT ATTGACCTGG ACTCCCAGAG GAAGGGCAAG 
TGTGCTGTGA TCAAAACCTC TACACGACAG ACGTACTTCC TTCCTGTGAT TGGGTTGGTG 
GATGCTGAAA AGCTAAAGCC AGGAGACCTG GTGGGTGTGA ACAAAGACTC CTATCTGATC 
CTGGAGACGC TGCCCACAGA GTATGACTCG CGGGTGAAGG CCATGGAGGT AGACGAGAGG 
CCCACGGAGC AATACAGTGA CATTGGGGGT TTGGACAAGC AGATCCAGGA GCTGGTGGAG 
GCCATTGTCT TGCCAATGAA CCACAAGGAG AAGTTTGAGA ACTTGGGGAT CCAACCTCCA 
AAAGGGGTGC TGATGTATGG GCCCCCAGGG ACGGGGAAGA CCCTCCTGGC CCGGGCCTGT 
GCCGCACAGA CTAAGGCCAC CTTCCTAAAG CTGGCTGGCC CCCAGCTGGT GCAGATGTTC 
ATTGGAGATG GTGCCAAGCT AGTCCGGGAT GCCTTTGCCC TGGCCAAGGA GAAAGCGCCC 
TCTATCATCT TCATTGATGA GTTGGATGCC ATCGGCACCA AGCGCTTTGA CAGTGAGAAG 
GCTGGGGACC GGGAGGTGCA GAGGACAATG CTGGAGCTTC TGAACCAGCT GGATGGCTTC 
CAGCCCAACA CCCAAGTTAA GGTAATTGCA GCCACAAACA GGGTGGACAT CCTGGACCCC 
GCCCTCCTCC GCTCGGGCCG CCTTGACCGC AAGATAGAGT TCCCGATGCC CAATGAGGAG 
GCCCGGGCCA GAATCATGCA GATCCACTCC CGAAAGATGA ATGTCAGTCC TGACGTGAAC 
TACGAGGAGC TGGCCCGCTG CACAGATGAC TTCAATGGGG CCCAGTGCAA GGCTGTGTGT 
GTGGAGGCGG TGAGTGGTCA GCTGGGGTGG GTGCGTTGCT TTGTGCCTTC TTGCCCCCTC 
CCTGGACAGG ATGGGGGCAT TTGGCTGGTG GAGACGGCTG AGGGAAGAGG CCTGAGCCTC 
AGGGAGCCAG GGAAGGCATT CAGGCGTTCA GACCTAGACT CTGTTTGTCC CGGCTGTAGG 
GCATGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

PubMed

Architecture of the human interactome defines protein communities and disease networks.
Nature545(7655)505-509(2017 05)
Huttlin EL,Bruckner RJ,Paulo JA,Cannon JR,Ting L,Baltier K,Colby G,Gebreab F,Gygi MP,Parzen H,Szpyt J,Tam S,Zarraga G,Pontano-Vaites L,Swarup S,White AE,Schweppe DK,Rad R,Erickson BK,Obar RA,Guruharsha KG,Li K,Artavanis-Tsakonas S,Gygi SP,Harper JW

Protein interaction network of the mammalian Hippo pathway reveals mechanisms of kinase-phosphatase interactions.
Science signaling6(302)rs15(2013 Nov)
Couzens AL,Knight JD,Kean MJ,Teo G,Weiss A,Dunham WH,Lin ZY,Bagshaw RD,Sicheri F,Pawson T,Wrana JL,Choi H,Gingras AC

Genome-wide meta-analysis identifies 11 new loci for anthropometric traits and provides insights into genetic architecture.
Nature genetics45(5)501-12(2013 May)
Berndt SI,Gustafsson S,M?gi R,Ganna A,Wheeler E,Feitosa MF,Justice AE,Monda KL,Croteau-Chonka DC,Day FR,Esko T,Fall T,Ferreira T,Gentilini D,Jackson AU,Luan J,Randall JC,Vedantam S,Willer CJ,Winkler TW,Wood AR,Workalemahu T,Hu YJ,Lee SH,Liang L,Lin DY,Min JL,Neale BM,Thorleifsson G,Yang J,Albrecht E,Amin N,Bragg-Gresham JL,Cadby G,den Heijer M,Eklund N,Fischer K,Goel A,Hottenga JJ,Huffman JE,Jarick I,Johansson ?,Johnson T,Kanoni S,Kleber ME,K?nig IR,Kristiansson K,Kutalik Z,Lamina C,Lecoeur C,Li G,Mangino M,McArdle WL,Medina-Gomez C,M?ller-Nurasyid M,Ngwa JS,Nolte IM,Paternoster L,Pechlivanis S,Perola M,Peters MJ,Preuss M,Rose LM,Shi J,Shungin D,Smith AV,Strawbridge RJ,Surakka I,Teumer A,Trip MD,Tyrer J,Van Vliet-Ostaptchouk JV,Vandenput L,Waite LL,Zhao JH,Absher D,Asselbergs FW,Atalay M,Attwood AP,Balmforth AJ,Basart H,Beilby J,Bonnycastle LL,Brambilla P,Bruinenberg M,Campbell H,Chasman DI,Chines PS,Collins FS,Connell JM,Cookson WO,de Faire U,de Vegt F,Dei M,Dimitriou M,Edkins S,Estrada K,Evans DM,Farrall M,Ferrario MM,Ferri?res J,Franke L,Frau F,Gejman PV,Grallert H,Gr?nberg H,Gudnason V,Hall AS,Hall P,Hartikainen AL,Hayward C,Heard-Costa NL,Heath AC,Hebebrand J,Homuth G,Hu FB,Hunt SE,Hypp?nen E,Iribarren C,Jacobs KB,Jansson JO,Jula A,K?h?nen M,Kathiresan S,Kee F,Khaw KT,Kivim?ki M,Koenig W,Kraja AT,Kumari M,Kuulasmaa K,Kuusisto J,Laitinen JH,Lakka TA,Langenberg C,Launer LJ,Lind L,Lindstr?m J,Liu J,Liuzzi A,Lokki ML,Lorentzon M,Madden PA,Magnusson PK,Manunta P,Marek D,M?rz W,Mateo Leach I,McKnight B,Medland SE,Mihailov E,Milani L,Montgomery GW,Mooser V,M?hleisen TW,Munroe PB,Musk AW,Narisu N,Navis G,Nicholson G,Nohr EA,Ong KK,Oostra BA,Palmer CN,Palotie A,Peden JF,Pedersen N,Peters A,Polasek O,Pouta A,Pramstaller PP,Prokopenko I,P?tter C,Radhakrishnan A,Raitakari O,Rendon A,Rivadeneira F,Rudan I,Saaristo TE,Sambrook JG,Sanders AR,Sanna S,Saramies J,Schipf S,Schreiber S,Schunkert H,Shin SY,Signorini S,Sinisalo J,Skrobek B,Soranzo N,Stan??kov? A,Stark K,Stephens JC,Stirrups K,Stolk RP,Stumvoll M,Swift AJ,Theodoraki EV,Thorand B,Tregouet DA,Tremoli E,Van der Klauw MM,van Meurs JB,Vermeulen SH,Viikari J,Virtamo J,Vitart V,Waeber G,Wang Z,Wid?n E,Wild SH,Willemsen G,Winkelmann BR,Witteman JC,Wolffenbuttel BH,Wong A,Wright AF,Zillikens MC,Amouyel P,Boehm BO,Boerwinkle E,Boomsma DI,Caulfield MJ,Chanock SJ,Cupples LA,Cusi D,Dedoussis GV,Erdmann J,Eriksson JG,Franks PW,Froguel P,Gieger C,Gyllensten U,Hamsten A,Harris TB,Hengstenberg C,Hicks AA,Hingorani A,Hinney A,Hofman A,Hovingh KG,Hveem K,Illig T,Jarvelin MR,J?ckel KH,Keinanen-Kiukaanniemi SM,Kiemeney LA,Kuh D,Laakso M,Lehtim?ki T,Levinson DF,Martin NG,Metspalu A,Morris AD,Nieminen MS,Nj?lstad I,Ohlsson C,Oldehinkel AJ,Ouwehand WH,Palmer LJ,Penninx B,Power C,Province MA,Psaty BM,Qi L,Rauramaa R,Ridker PM,Ripatti S,Salomaa V,Samani NJ,Snieder H,S?rensen TI,Spector TD,Stefansson K,T?njes A,Tuomilehto J,Uitterlinden AG,Uusitupa M,van der Harst P,Vollenweider P,Wallaschofski H,Wareham NJ,Watkins H,Wichmann HE,Wilson JF,Abecasis GR,Assimes TL,Barroso I,Boehnke M,Borecki IB,Deloukas P,Fox CS,Frayling T,Groop LC,Haritunian T,Heid IM,Hunter D,Kaplan RC,Karpe F,Moffatt MF,Mohlke KL,O'Connell JR,Pawitan Y,Schadt EE,Schlessinger D,Steinthorsdottir V,Strachan DP,Thorsteinsdottir U,van Duijn CM,Visscher PM,Di Blasio AM,Hirschhorn JN,Lindgren CM,Morris AP,Meyre D,Scherag A,McCarthy MI,Speliotes EK,North KE,Loos RJ,Ingelsson E

Discovery and fine mapping of serum protein loci through transethnic meta-analysis.
American journal of human genetics91(4)744-53(2012 Oct)
Franceschini N,van Rooij FJ,Prins BP,Feitosa MF,Karakas M,Eckfeldt JH,Folsom AR,Kopp J,Vaez A,Andrews JS,Baumert J,Boraska V,Broer L,Hayward C,Ngwa JS,Okada Y,Polasek O,Westra HJ,Wang YA,Del Greco M F,Glazer NL,Kapur K,Kema IP,Lopez LM,Schillert A,Smith AV,Winkler CA,Zgaga L,,Bandinelli S,Bergmann S,Boban M,Bochud M,Chen YD,Davies G,Dehghan A,Ding J,Doering A,Durda JP,Ferrucci L,Franco OH,Franke L,Gunjaca G,Hofman A,Hsu FC,Kolcic I,Kraja A,Kubo M,Lackner KJ,Launer L,Loehr LR,Li G,Meisinger C,Nakamura Y,Schwienbacher C,Starr JM,Takahashi A,Torlak V,Uitterlinden AG,Vitart V,Waldenberger M,Wild PS,Kirin M,Zeller T,Zemunik T,Zhang Q,Ziegler A,Blankenberg S,Boerwinkle E,Borecki IB,Campbell H,Deary IJ,Frayling TM,Gieger C,Harris TB,Hicks AA,Koenig W,O' Donnell CJ,Fox CS,Pramstaller PP,Psaty BM,Reiner AP,Rotter JI,Rudan I,Snieder H,Tanaka T,van Duijn CM,Vollenweider P,Waeber G,Wilson JF,Witteman JC,Wolffenbuttel BH,Wright AF,Wu Q,Liu Y,Jenny NS,North KE,Felix JF,Alizadeh BZ,Cupples LA,Perry JR,Morris AP

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PSMC3 cDNA ORF clone, Homo sapiens(human)

Gene

Clones

gRNAs

Related articles in PubMed

Target ORF information:

Target ORF information:

ORF Insert Sequence:

Target ORF information:

Target ORF information:

ORF Insert Sequence:

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