KLHL9 cDNA ORF clone, Homo sapiens(Human)

Gene
Clones
gRNAs

Summary

Gene Symbol	KLHL9
Entrez Gene ID	55958
Full Name	kelch like family member 9
General protein information	Preferred Names kelch like family member 9 Names kelch-like protein 9
Gene Type	protein-coding
Organism	Homo sapiens(Human)
Genome	Chromosome: 9 Map Location: 9p21.3
Summary	This gene encodes a protein that belongs to the kelch repeat-containing family, and contains an N-terminal BTB/POZ domain, a BACK domain and six C-terminal kelch repeats. The encoded protein is a component of a complex with cullin 3-based E3 ligase, which plays a role in mitosis. This protein complex is a cell cycle regulator, and functions in the organization and integrity of the spindle midzone in anaphase and the completion of cytokinesis. The complex is required for the removal of the chromosomal passenger protein aurora B from mitotic chromosomes. [provided by RefSeq, Jul 2016]. COMPLETENESS: complete on the 3' end.
Disorder MIM:	611201

mRNA and Protein(s)

mRNA	Protein	Name
NM_018847.3	NP_061335.1	kelch-like protein 9
NM_018847.4	NP_061335.1	kelch-like protein 9
NM_018847.2	NP_061335.1	kelch-like protein 9

Pathways from BioSystems

Homologies

	KLHL9	XP_002800153.1
Canis lupus familiaris (dog)	LOC100688162	XP_005626732.1
Mus musculus (house mouse)	Klhl9	NP_766459.2
Rattus norvegicus (Norway rat)	Klhl9	NP_001101414.1
Danio rerio (zebrafish)	klhl13	NP_001231683.1
Xenopus tropicalis (tropical clawed frog)	klhl13	NP_001008095.1
Bos taurus (cattle)	KLHL9	NP_001070424.1
Gallus gallus (chicken)	KLHL13	NP_001026287.1
Homo sapiens (human)	KLHL9	NP_061335.1
Pan troglodytes (chimpanzee)	KLHL9	XP_003951451.1

Gene Ontology
Bibliography

Related articles in PubMed

Update on the Kelch-like (KLHL) gene family.
Dhanoa BS, Cogliati T, Satish AG, Bruford EA, Friedman JS
Human genomics713(2013 May)

Associations of 9p21 variants with cutaneous malignant melanoma, nevi, and pigmentation phenotypes in melanoma-prone families with and without CDKN2A mutations.
Yang XR, Liang X, Pfeiffer RM, Wheeler W, Maeder D, Burdette L, Yeager M, Chanock S, Tucker MA, Goldstein AM
Familial cancer9(4)625-33(2010 Dec)

Kelch-like homologue 9 mutation is associated with an early onset autosomal dominant distal myopathy.
Cirak S, von Deimling F, Sachdev S, Errington WJ, Herrmann R, B?nnemann C, Brockmann K, Hinderlich S, Lindner TH, Steinbrecher A, Hoffmann K, Priv? GG, Hannink M, N?rnberg P, Voit T
Brain : a journal of neurology133(Pt 7)2123-35(2010 Jul)

The Cul3-KLHL21 E3 ubiquitin ligase targets aurora B to midzone microtubules in anaphase and is required for cytokinesis.
Maerki S, Olma MH, Staubli T, Steigemann P, Gerlich DW, Quadroni M, Sumara I, Peter M
The Journal of cell biology187(6)791-800(2009 Dec)

A Cul3-based E3 ligase removes Aurora B from mitotic chromosomes, regulating mitotic progression and completion of cytokinesis in human cells.
Sumara I, Quadroni M, Frei C, Olma MH, Sumara G, Ricci R, Peter M
Developmental cell12(6)887-900(2007 Jun)

GeneRIFs: Gene References Into Functions What's a GeneRIF?

Observational study of gene-disease association. (HuGE Navigator)
Title: Associations of 9p21 variants with cutaneous malignant melanoma, nevi, and pigmentation phenotypes in melanoma-prone families with and without CDKN2A mutations.

A unique form of early onset autosomal dominant distal myopathy is associated with a kelch-like homologue 9 mutation and interferes with normal skeletal muscle through a novel pathogenetic mechanism.
Title: Kelch-like homologue 9 mutation is associated with an early onset autosomal dominant distal myopathy.

The following KLHL9 gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the KLHL9 cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1⁺/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.

***CloneID	Accession No.	Definition	**Vector	*Turnaround time	Price (USD)
OHu13310	NM_018847.4 Latest version!	Homo sapiens kelch like family member 9 (KLHL9), mRNA.	pcDNA3.1-C-(k)DYK or customized vector	in pcDNA3.1-C-(k)DYK	$219.50-$307.30 $439.00
View Old Accession Versions >>
OHu13310	NM_018847.3	Homo sapiens kelch like family member 9 (KLHL9), mRNA.	pcDNA3.1-C-(k)DYK or customized vector	in pcDNA3.1-C-(k)DYK	$219.50-$307.30 $439.00
OHu13310	NM_018847.2	Homo sapiens kelch-like family member 9 (KLHL9), mRNA.	pcDNA3.1-C-(k)DYK or customized vector	in pcDNA3.1-C-(k)DYK	$219.50-$307.30 $439.00
Hide Old Accession Versions >>

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***One clone ID might be correlated to multiple accession numbers, which share the same CDS sequence.

Reference Sequences (Refseq)

KLHL9 ( NM_018847.3 ) cDNA ORF clone, Homo sapiens(Human) -> NP_061335.1 Homo sapiens kelch like family member 9 (KLHL9), mRNA.

Price & Availability↑

CloneID	OHu13310
Clone ID Related Accession (Same CDS sequence)	NM_018847.3 , NM_018847.4 , NM_018847.2
Accession Version	NM_018847.3	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 1854bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2018-06-30
Organism	Homo sapiens(human)
Product	kelch-like protein 9
Comment	Comment: REVIEWED REFSEQ: This record has been curated by NCBI staff. The reference sequence was derived from AL162420.13, DB237245.1, AB037775.1 and BC052776.1. This sequence is a reference standard in the RefSeqGene project. On Jul 20, 2016 this sequence version replaced NM_018847.2. COMPLETENESS: complete on the 3' end.

ATGAAAGTGT CCCTTGGTAA CGGCGAAATG GGCGTCTCTG CCCATTTGCA GCCTTGTAAG 
GCAGGAACCA CACGCTTTTT TACCAGCAAT ACTCACAGTT CGGTGGTATT GCAAGGCTTT 
GATCAGCTTA GAATAGAAGG ATTGCTTTGT GATGTGACCC TGGTACCAGG TGATGGAGAT 
GAAATCTTCC CTGTTCACAG AGCTATGATG GCGTCTGCTA GTGATTATTT CAAAGCCATG 
TTCACAGGTG GAATGAAAGA ACAAGATTTG ATGTGCATTA AGCTTCATGG GGTGAACAAG 
GTTGGTCTGA AGAAAATCAT TGATTTTATT TATACTGCAA AACTTTCTCT TAATATGGAC 
AATCTTCAGG ACACACTTGA AGCTGCTAGC TTTTTACAAA TATTACCCGT TTTGGATTTC 
TGTAAAGTAT TTCTTATATC AGGAGTCTCT TTGGATAACT GTGTTGAGGT TGGACGAATT 
GCTAACACCT ACAATCTTAT AGAAGTGGAT AAATATGTTA ATAATTTCAT CCTGAAGAAC 
TTTCCTGCTT TATTGAGTAC TGGGGAGTTT CTAAAACTCC CTTTTGAACG ACTTGCATTT 
GTGCTTTCCA GTAATAGTCT TAAGCACTGT ACCGAACTTG AACTCTTTAA GGCAGCCTGT 
CGCTGGCTAA GGTTGGAAGA CCCTCGGATG GATTATGCTG CAAAGTTAAT GAAGAATATT 
CGATTTCCAC TGATGACACC ACAGGATCTC ATCAATTACG TGCAGACAGT AGATTTCATG 
AGAACAGACA ATACCTGCGT GAATTTGCTT TTGGAAGCTA GCAATTACCA AATGATGCCA 
TATATGCAGC CAGTGATGCA GTCAGATAGA ACTGCCATTC GATCTGACTC CACTCACTTG 
GTTACATTAG GAGGAGTTTT GAGGCAGCAG CTGGTTGTCA GTAAAGAATT ACGGATGTAT 
GATGAAAGGG CACAAGAATG GAGATCTTTA GCCCCAATGG ATGCTCCCCG TTACCAGCAT 
GGTATTGCTG TCATTGGAAA CTTTCTTTAT GTAGTTGGTG GTCAGAGTAA TTATGATACA 
AAAGGAAAAA CTGCTGTTGA TACAGTTTTC AGATTTGATC CTCGGTATAA TAAATGGATG 
CAGGTTGCAT CATTAAATGA AAAGCGCACA TTCTTTCACT TGAGTGCCCT CAAAGGACAT 
TTGTATGCAG TTGGTGGGCG CAGTGCAGCT GGTGAACTGG CCACAGTAGA ATGTTACAAC 
CCAAGAATGA ATGAGTGGAG CTATGTTGCA AAAATGAGTG AACCCCACTA TGGTCATGCT 
GGAACAGTAT ATGGAGGCTT AATGTATATT TCAGGAGGAA TTACCCATGA CACTTTCCAA 
AATGAGCTCA TGTGTTTTGA CCCAGATACA GATAAATGGA TGCAAAAGGC TCCAATGACT 
ACAGTCAGAG GTCTGCATTG CATGTGTACA GTTGGAGATA AGCTCTATGT CATTGGTGGC 
AATCACTTCA GAGGAACAAG TGATTATGAT GATGTTCTAA GCTGTGAATA CTATTCACCA 
ACCCTTGACC AGTGGACCCC AATTGCCGCC ATGTTAAGAG GCCAAAGTGA TGTTGGAGTT 
GCCGTCTTTG AAAATAAAAT CTATGTTGTT GGTGGATATT CTTGGAATAA TCGTTGTATG 
GTAGAAATTG TCCAGAAATA TGACCCAGAA AAAGATGAGT GGCATAAAGT TTTTGATCTT 
CCAGAGTCAC TTGGTGGCAT TCGAGCCTGT ACACTCACAG TTTTTCCACC TGAAGAAAAC 
CCTGGGTCAC CTTCTAGAGA ATCACCTCTT TCAGCACCTT CAGATCATTC TTAG

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_061335.1
CDS	574..2427
Translation	MKVSLGNGEMGVSAHLQPCKAGTTRFFTSNTHSSVVLQGFDQLRIEGLLCDVTLVPGDGDEIFPVHRAMMASASDYFKAMFTGGMKEQDLMCIKLHGVNKVGLKKIIDFIYTAKLSLNMDNLQDTLEAASFLQILPVLDFCKVFLISGVSLDNCVEVGRIANTYNLIEVDKYVNNFILKNFPALLSTGEFLKLPFERLAFVLSSNSLKHCTELELFKAACRWLRLEDPRMDYAAKLMKNIRFPLMTPQDLINYVQTVDFMRTDNTCVNLLLEASNYQMMPYMQPVMQSDRTAIRSDSTHLVTLGGVLRQQLVVSKELRMYDERAQEWRSLAPMDAPRYQHGIAVIGNFLYVVGGQSNYDTKGKTAVDTVFRFDPRYNKWMQVASLNEKRTFFHLSALKGHLYAVGGRSAAGELATVECYNPRMNEWSYVAKMSEPHYGHAGTVYGGLMYISGGITHDTFQNELMCFDPDTDKWMQKAPMTTVRGLHCMCTVGDKLYVIGGNHFRGTSDYDDVLSCEYYSPTLDQWTPIAAMLRGQSDVGVAVFENKIYVVGGYSWNNRCMVEIVQKYDPEKDEWHKVFDLPESLGGIRACTLTVFPPEENPGSPSRESPLSAPSDHS

Target ORF information:

RefSeq Version	NM_018847.3
Organism	Homo sapiens(human)
Definition	Homo sapiens kelch like family member 9 (KLHL9), mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_018847.3

ORF Insert Sequence:

ATGAAAGTGT CCCTTGGTAA CGGCGAAATG GGCGTCTCTG CCCATTTGCA GCCTTGTAAG 
GCAGGAACCA CACGCTTTTT TACCAGCAAT ACTCACAGTT CGGTGGTATT GCAAGGCTTT 
GATCAGCTTA GAATAGAAGG ATTGCTTTGT GATGTGACCC TGGTACCAGG TGATGGAGAT 
GAAATCTTCC CTGTTCACAG AGCTATGATG GCGTCTGCTA GTGATTATTT CAAAGCCATG 
TTCACAGGTG GAATGAAAGA ACAAGATTTG ATGTGCATTA AGCTTCATGG GGTGAACAAG 
GTTGGTCTGA AGAAAATCAT TGATTTTATT TATACTGCAA AACTTTCTCT TAATATGGAC 
AATCTTCAGG ACACACTTGA AGCTGCTAGC TTTTTACAAA TATTACCCGT TTTGGATTTC 
TGTAAAGTAT TTCTTATATC AGGAGTCTCT TTGGATAACT GTGTTGAGGT TGGACGAATT 
GCTAACACCT ACAATCTTAT AGAAGTGGAT AAATATGTTA ATAATTTCAT CCTGAAGAAC 
TTTCCTGCTT TATTGAGTAC TGGGGAGTTT CTAAAACTCC CTTTTGAACG ACTTGCATTT 
GTGCTTTCCA GTAATAGTCT TAAGCACTGT ACCGAACTTG AACTCTTTAA GGCAGCCTGT 
CGCTGGCTAA GGTTGGAAGA CCCTCGGATG GATTATGCTG CAAAGTTAAT GAAGAATATT 
CGATTTCCAC TGATGACACC ACAGGATCTC ATCAATTACG TGCAGACAGT AGATTTCATG 
AGAACAGACA ATACCTGCGT GAATTTGCTT TTGGAAGCTA GCAATTACCA AATGATGCCA 
TATATGCAGC CAGTGATGCA GTCAGATAGA ACTGCCATTC GATCTGACTC CACTCACTTG 
GTTACATTAG GAGGAGTTTT GAGGCAGCAG CTGGTTGTCA GTAAAGAATT ACGGATGTAT 
GATGAAAGGG CACAAGAATG GAGATCTTTA GCCCCAATGG ATGCTCCCCG TTACCAGCAT 
GGTATTGCTG TCATTGGAAA CTTTCTTTAT GTAGTTGGTG GTCAGAGTAA TTATGATACA 
AAAGGAAAAA CTGCTGTTGA TACAGTTTTC AGATTTGATC CTCGGTATAA TAAATGGATG 
CAGGTTGCAT CATTAAATGA AAAGCGCACA TTCTTTCACT TGAGTGCCCT CAAAGGACAT 
TTGTATGCAG TTGGTGGGCG CAGTGCAGCT GGTGAACTGG CCACAGTAGA ATGTTACAAC 
CCAAGAATGA ATGAGTGGAG CTATGTTGCA AAAATGAGTG AACCCCACTA TGGTCATGCT 
GGAACAGTAT ATGGAGGCTT AATGTATATT TCAGGAGGAA TTACCCATGA CACTTTCCAA 
AATGAGCTCA TGTGTTTTGA CCCAGATACA GATAAATGGA TGCAAAAGGC TCCAATGACT 
ACAGTCAGAG GTCTGCATTG CATGTGTACA GTTGGAGATA AGCTCTATGT CATTGGTGGC 
AATCACTTCA GAGGAACAAG TGATTATGAT GATGTTCTAA GCTGTGAATA CTATTCACCA 
ACCCTTGACC AGTGGACCCC AATTGCCGCC ATGTTAAGAG GCCAAAGTGA TGTTGGAGTT 
GCCGTCTTTG AAAATAAAAT CTATGTTGTT GGTGGATATT CTTGGAATAA TCGTTGTATG 
GTAGAAATTG TCCAGAAATA TGACCCAGAA AAAGATGAGT GGCATAAAGT TTTTGATCTT 
CCAGAGTCAC TTGGTGGCAT TCGAGCCTGT ACACTCACAG TTTTTCCACC TGAAGAAAAC 
CCTGGGTCAC CTTCTAGAGA ATCACCTCTT TCAGCACCTT CAGATCATTC TTAG

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

KLHL9 ( NM_018847.4 ) cDNA ORF clone, Homo sapiens(Human) -> NP_061335.1 Homo sapiens kelch like family member 9 (KLHL9), mRNA.

Price & Availability↑

CloneID	OHu13310
Clone ID Related Accession (Same CDS sequence)	NM_018847.3 , NM_018847.4 , NM_018847.2
Accession Version	NM_018847.4 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 1854bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-10-25
Organism	Homo sapiens(human)
Product	kelch-like protein 9
Comment	Comment: REVIEWED REFSEQ: This record has been curated by NCBI staff. The reference sequence was derived from DB237245.1, AB037775.1, BC052776.1 and AL162420.13. This sequence is a reference standard in the RefSeqGene project. On May 17, 2019 this sequence version replaced NM_018847.3. ##Evidence-Data-START## Transcript is intronless :: SRR1803614.109379.1, SRR1803616.49521.1 [ECO:0000345] ##Evidence-Data-END## ##RefSeq-Attributes-START## MANE Ensembl match :: ENST00000359039.5/ ENSP00000351933.4 RefSeq Select criteria :: based on single protein-coding transcript ##RefSeq-Attributes-END## COMPLETENESS: complete on the 3' end.

ATGAAAGTGT CCCTTGGTAA CGGCGAAATG GGCGTCTCTG CCCATTTGCA GCCTTGTAAG 
GCAGGAACCA CACGCTTTTT TACCAGCAAT ACTCACAGTT CGGTGGTATT GCAAGGCTTT 
GATCAGCTTA GAATAGAAGG ATTGCTTTGT GATGTGACCC TGGTACCAGG TGATGGAGAT 
GAAATCTTCC CTGTTCACAG AGCTATGATG GCGTCTGCTA GTGATTATTT CAAAGCCATG 
TTCACAGGTG GAATGAAAGA ACAAGATTTG ATGTGCATTA AGCTTCATGG GGTGAACAAG 
GTTGGTCTGA AGAAAATCAT TGATTTTATT TATACTGCAA AACTTTCTCT TAATATGGAC 
AATCTTCAGG ACACACTTGA AGCTGCTAGC TTTTTACAAA TATTACCCGT TTTGGATTTC 
TGTAAAGTAT TTCTTATATC AGGAGTCTCT TTGGATAACT GTGTTGAGGT TGGACGAATT 
GCTAACACCT ACAATCTTAT AGAAGTGGAT AAATATGTTA ATAATTTCAT CCTGAAGAAC 
TTTCCTGCTT TATTGAGTAC TGGGGAGTTT CTAAAACTCC CTTTTGAACG ACTTGCATTT 
GTGCTTTCCA GTAATAGTCT TAAGCACTGT ACCGAACTTG AACTCTTTAA GGCAGCCTGT 
CGCTGGCTAA GGTTGGAAGA CCCTCGGATG GATTATGCTG CAAAGTTAAT GAAGAATATT 
CGATTTCCAC TGATGACACC ACAGGATCTC ATCAATTACG TGCAGACAGT AGATTTCATG 
AGAACAGACA ATACCTGCGT GAATTTGCTT TTGGAAGCTA GCAATTACCA AATGATGCCA 
TATATGCAGC CAGTGATGCA GTCAGATAGA ACTGCCATTC GATCTGACTC CACTCACTTG 
GTTACATTAG GAGGAGTTTT GAGGCAGCAG CTGGTTGTCA GTAAAGAATT ACGGATGTAT 
GATGAAAGGG CACAAGAATG GAGATCTTTA GCCCCAATGG ATGCTCCCCG TTACCAGCAT 
GGTATTGCTG TCATTGGAAA CTTTCTTTAT GTAGTTGGTG GTCAGAGTAA TTATGATACA 
AAAGGAAAAA CTGCTGTTGA TACAGTTTTC AGATTTGATC CTCGGTATAA TAAATGGATG 
CAGGTTGCAT CATTAAATGA AAAGCGCACA TTCTTTCACT TGAGTGCCCT CAAAGGACAT 
TTGTATGCAG TTGGTGGGCG CAGTGCAGCT GGTGAACTGG CCACAGTAGA ATGTTACAAC 
CCAAGAATGA ATGAGTGGAG CTATGTTGCA AAAATGAGTG AACCCCACTA TGGTCATGCT 
GGAACAGTAT ATGGAGGCTT AATGTATATT TCAGGAGGAA TTACCCATGA CACTTTCCAA 
AATGAGCTCA TGTGTTTTGA CCCAGATACA GATAAATGGA TGCAAAAGGC TCCAATGACT 
ACAGTCAGAG GTCTGCATTG CATGTGTACA GTTGGAGATA AGCTCTATGT CATTGGTGGC 
AATCACTTCA GAGGAACAAG TGATTATGAT GATGTTCTAA GCTGTGAATA CTATTCACCA 
ACCCTTGACC AGTGGACCCC AATTGCCGCC ATGTTAAGAG GCCAAAGTGA TGTTGGAGTT 
GCCGTCTTTG AAAATAAAAT CTATGTTGTT GGTGGATATT CTTGGAATAA TCGTTGTATG 
GTAGAAATTG TCCAGAAATA TGACCCAGAA AAAGATGAGT GGCATAAAGT TTTTGATCTT 
CCAGAGTCAC TTGGTGGCAT TCGAGCCTGT ACACTCACAG TTTTTCCACC TGAAGAAAAC 
CCTGGGTCAC CTTCTAGAGA ATCACCTCTT TCAGCACCTT CAGATCATTC TTAG

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_061335.1
CDS	546..2399
Translation	MKVSLGNGEMGVSAHLQPCKAGTTRFFTSNTHSSVVLQGFDQLRIEGLLCDVTLVPGDGDEIFPVHRAMMASASDYFKAMFTGGMKEQDLMCIKLHGVNKVGLKKIIDFIYTAKLSLNMDNLQDTLEAASFLQILPVLDFCKVFLISGVSLDNCVEVGRIANTYNLIEVDKYVNNFILKNFPALLSTGEFLKLPFERLAFVLSSNSLKHCTELELFKAACRWLRLEDPRMDYAAKLMKNIRFPLMTPQDLINYVQTVDFMRTDNTCVNLLLEASNYQMMPYMQPVMQSDRTAIRSDSTHLVTLGGVLRQQLVVSKELRMYDERAQEWRSLAPMDAPRYQHGIAVIGNFLYVVGGQSNYDTKGKTAVDTVFRFDPRYNKWMQVASLNEKRTFFHLSALKGHLYAVGGRSAAGELATVECYNPRMNEWSYVAKMSEPHYGHAGTVYGGLMYISGGITHDTFQNELMCFDPDTDKWMQKAPMTTVRGLHCMCTVGDKLYVIGGNHFRGTSDYDDVLSCEYYSPTLDQWTPIAAMLRGQSDVGVAVFENKIYVVGGYSWNNRCMVEIVQKYDPEKDEWHKVFDLPESLGGIRACTLTVFPPEENPGSPSRESPLSAPSDHS

Target ORF information:

RefSeq Version	NM_018847.4
Organism	Homo sapiens(human)
Definition	Homo sapiens kelch like family member 9 (KLHL9), mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_018847.4

ORF Insert Sequence:

ATGAAAGTGT CCCTTGGTAA CGGCGAAATG GGCGTCTCTG CCCATTTGCA GCCTTGTAAG 
GCAGGAACCA CACGCTTTTT TACCAGCAAT ACTCACAGTT CGGTGGTATT GCAAGGCTTT 
GATCAGCTTA GAATAGAAGG ATTGCTTTGT GATGTGACCC TGGTACCAGG TGATGGAGAT 
GAAATCTTCC CTGTTCACAG AGCTATGATG GCGTCTGCTA GTGATTATTT CAAAGCCATG 
TTCACAGGTG GAATGAAAGA ACAAGATTTG ATGTGCATTA AGCTTCATGG GGTGAACAAG 
GTTGGTCTGA AGAAAATCAT TGATTTTATT TATACTGCAA AACTTTCTCT TAATATGGAC 
AATCTTCAGG ACACACTTGA AGCTGCTAGC TTTTTACAAA TATTACCCGT TTTGGATTTC 
TGTAAAGTAT TTCTTATATC AGGAGTCTCT TTGGATAACT GTGTTGAGGT TGGACGAATT 
GCTAACACCT ACAATCTTAT AGAAGTGGAT AAATATGTTA ATAATTTCAT CCTGAAGAAC 
TTTCCTGCTT TATTGAGTAC TGGGGAGTTT CTAAAACTCC CTTTTGAACG ACTTGCATTT 
GTGCTTTCCA GTAATAGTCT TAAGCACTGT ACCGAACTTG AACTCTTTAA GGCAGCCTGT 
CGCTGGCTAA GGTTGGAAGA CCCTCGGATG GATTATGCTG CAAAGTTAAT GAAGAATATT 
CGATTTCCAC TGATGACACC ACAGGATCTC ATCAATTACG TGCAGACAGT AGATTTCATG 
AGAACAGACA ATACCTGCGT GAATTTGCTT TTGGAAGCTA GCAATTACCA AATGATGCCA 
TATATGCAGC CAGTGATGCA GTCAGATAGA ACTGCCATTC GATCTGACTC CACTCACTTG 
GTTACATTAG GAGGAGTTTT GAGGCAGCAG CTGGTTGTCA GTAAAGAATT ACGGATGTAT 
GATGAAAGGG CACAAGAATG GAGATCTTTA GCCCCAATGG ATGCTCCCCG TTACCAGCAT 
GGTATTGCTG TCATTGGAAA CTTTCTTTAT GTAGTTGGTG GTCAGAGTAA TTATGATACA 
AAAGGAAAAA CTGCTGTTGA TACAGTTTTC AGATTTGATC CTCGGTATAA TAAATGGATG 
CAGGTTGCAT CATTAAATGA AAAGCGCACA TTCTTTCACT TGAGTGCCCT CAAAGGACAT 
TTGTATGCAG TTGGTGGGCG CAGTGCAGCT GGTGAACTGG CCACAGTAGA ATGTTACAAC 
CCAAGAATGA ATGAGTGGAG CTATGTTGCA AAAATGAGTG AACCCCACTA TGGTCATGCT 
GGAACAGTAT ATGGAGGCTT AATGTATATT TCAGGAGGAA TTACCCATGA CACTTTCCAA 
AATGAGCTCA TGTGTTTTGA CCCAGATACA GATAAATGGA TGCAAAAGGC TCCAATGACT 
ACAGTCAGAG GTCTGCATTG CATGTGTACA GTTGGAGATA AGCTCTATGT CATTGGTGGC 
AATCACTTCA GAGGAACAAG TGATTATGAT GATGTTCTAA GCTGTGAATA CTATTCACCA 
ACCCTTGACC AGTGGACCCC AATTGCCGCC ATGTTAAGAG GCCAAAGTGA TGTTGGAGTT 
GCCGTCTTTG AAAATAAAAT CTATGTTGTT GGTGGATATT CTTGGAATAA TCGTTGTATG 
GTAGAAATTG TCCAGAAATA TGACCCAGAA AAAGATGAGT GGCATAAAGT TTTTGATCTT 
CCAGAGTCAC TTGGTGGCAT TCGAGCCTGT ACACTCACAG TTTTTCCACC TGAAGAAAAC 
CCTGGGTCAC CTTCTAGAGA ATCACCTCTT TCAGCACCTT CAGATCATTC TTAG

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

KLHL9 ( NM_018847.2 ) cDNA ORF clone, Homo sapiens(Human) -> NP_061335.1 Homo sapiens kelch-like family member 9 (KLHL9), mRNA.

Price & Availability↑

CloneID	OHu13310
Clone ID Related Accession (Same CDS sequence)	NM_018847.3 , NM_018847.4 , NM_018847.2
Accession Version	NM_018847.2	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 1854bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2014-03-22
Organism	Homo sapiens(Human)
Product	kelch-like protein 9
Comment

ATGAAAGTGT CCCTTGGTAA CGGCGAAATG GGCGTCTCTG CCCATTTGCA GCCTTGTAAG 
GCAGGAACCA CACGCTTTTT TACCAGCAAT ACTCACAGTT CGGTGGTATT GCAAGGCTTT 
GATCAGCTTA GAATAGAAGG ATTGCTTTGT GATGTGACCC TGGTACCAGG TGATGGAGAT 
GAAATCTTCC CTGTTCACAG AGCTATGATG GCGTCTGCTA GTGATTATTT CAAAGCCATG 
TTCACAGGTG GAATGAAAGA ACAAGATTTG ATGTGCATTA AGCTTCATGG GGTGAACAAG 
GTTGGTCTGA AGAAAATCAT TGATTTTATT TATACTGCAA AACTTTCTCT TAATATGGAC 
AATCTTCAGG ACACACTTGA AGCTGCTAGC TTTTTACAAA TATTACCCGT TTTGGATTTC 
TGTAAAGTAT TTCTTATATC AGGAGTCTCT TTGGATAACT GTGTTGAGGT TGGACGAATT 
GCTAACACCT ACAATCTTAT AGAAGTGGAT AAATATGTTA ATAATTTCAT CCTGAAGAAC 
TTTCCTGCTT TATTGAGTAC TGGGGAGTTT CTAAAACTCC CTTTTGAACG ACTTGCATTT 
GTGCTTTCCA GTAATAGTCT TAAGCACTGT ACCGAACTTG AACTCTTTAA GGCAGCCTGT 
CGCTGGCTAA GGTTGGAAGA CCCTCGGATG GATTATGCTG CAAAGTTAAT GAAGAATATT 
CGATTTCCAC TGATGACACC ACAGGATCTC ATCAATTACG TGCAGACAGT AGATTTCATG 
AGAACAGACA ATACCTGCGT GAATTTGCTT TTGGAAGCTA GCAATTACCA AATGATGCCA 
TATATGCAGC CAGTGATGCA GTCAGATAGA ACTGCCATTC GATCTGACTC CACTCACTTG 
GTTACATTAG GAGGAGTTTT GAGGCAGCAG CTGGTTGTCA GTAAAGAATT ACGGATGTAT 
GATGAAAGGG CACAAGAATG GAGATCTTTA GCCCCAATGG ATGCTCCCCG TTACCAGCAT 
GGTATTGCTG TCATTGGAAA CTTTCTTTAT GTAGTTGGTG GTCAGAGTAA TTATGATACA 
AAAGGAAAAA CTGCTGTTGA TACAGTTTTC AGATTTGATC CTCGGTATAA TAAATGGATG 
CAGGTTGCAT CATTAAATGA AAAGCGCACA TTCTTTCACT TGAGTGCCCT CAAAGGACAT 
TTGTATGCAG TTGGTGGGCG CAGTGCAGCT GGTGAACTGG CCACAGTAGA ATGTTACAAC 
CCAAGAATGA ATGAGTGGAG CTATGTTGCA AAAATGAGTG AACCCCACTA TGGTCATGCT 
GGAACAGTAT ATGGAGGCTT AATGTATATT TCAGGAGGAA TTACCCATGA CACTTTCCAA 
AATGAGCTCA TGTGTTTTGA CCCAGATACA GATAAATGGA TGCAAAAGGC TCCAATGACT 
ACAGTCAGAG GTCTGCATTG CATGTGTACA GTTGGAGATA AGCTCTATGT CATTGGTGGC 
AATCACTTCA GAGGAACAAG TGATTATGAT GATGTTCTAA GCTGTGAATA CTATTCACCA 
ACCCTTGACC AGTGGACCCC AATTGCCGCC ATGTTAAGAG GCCAAAGTGA TGTTGGAGTT 
GCCGTCTTTG AAAATAAAAT CTATGTTGTT GGTGGATATT CTTGGAATAA TCGTTGTATG 
GTAGAAATTG TCCAGAAATA TGACCCAGAA AAAGATGAGT GGCATAAAGT TTTTGATCTT 
CCAGAGTCAC TTGGTGGCAT TCGAGCCTGT ACACTCACAG TTTTTCCACC TGAAGAAAAC 
CCTGGGTCAC CTTCTAGAGA ATCACCTCTT TCAGCACCTT CAGATCATTC TTAG

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq

NP_061335.1

Translation

MKVSLGNGEMGVSAHLQPCKAGTTRFFTSNTHSSVVLQGFDQLRIEGLLCDVTLVPGDGDEIFPVHRAMMASASDYFKAMFTGGMKEQDLMCIKLHGVNKVGLKKIIDFIYTAKLSLNMDNLQDTLEAASFLQILPVLDFCKVFLISGVSLDNCVEVGRIANTYNLIEVDKYVNNFILKNFPALLSTGEFLKLPFERLAFVLSSNSLKHCTELELFKAACRWLRLEDPRMDYAAKLMKNIRFPLMTPQDLINYVQTVDFMRTDNTCVNLLLEASNYQMMPYMQPVMQSDRTAIRSDSTHLVTLGGVLRQQLVVSKELRMYDERAQEWRSLAPMDAPRYQHGIAVIGNFLYVVGGQSNYDTKGKTAVDTVFRFDPRYNKWMQVASLNEKRTFFHLSALKGHLYAVGGRSAAGELATVECYNPRMNEWSYVAKMSEPHYGHAGTVYGGLMYISGGITHDTFQNELMCFDPDTDKWMQKAPMTTVRGLHCMCTVGDKLYVIGGNHFRGTSDYDDVLSCEYYSPTLDQWTPIAAMLRGQSDVGVAVFENKIYVVGGYSWNNRCMVEIVQKYDPEKDEWHKVFDLPESLGGIRACTLTVFPPEENPGSPSRESPLSAPSDHS

Target ORF information:

RefSeq Version	NM_018847.2
Organism	Homo sapiens(Human)
Definition	Homo sapiens kelch-like family member 9 (KLHL9), mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_018847.2

ORF Insert Sequence:

ATGAAAGTGT CCCTTGGTAA CGGCGAAATG GGCGTCTCTG CCCATTTGCA GCCTTGTAAG 
GCAGGAACCA CACGCTTTTT TACCAGCAAT ACTCACAGTT CGGTGGTATT GCAAGGCTTT 
GATCAGCTTA GAATAGAAGG ATTGCTTTGT GATGTGACCC TGGTACCAGG TGATGGAGAT 
GAAATCTTCC CTGTTCACAG AGCTATGATG GCGTCTGCTA GTGATTATTT CAAAGCCATG 
TTCACAGGTG GAATGAAAGA ACAAGATTTG ATGTGCATTA AGCTTCATGG GGTGAACAAG 
GTTGGTCTGA AGAAAATCAT TGATTTTATT TATACTGCAA AACTTTCTCT TAATATGGAC 
AATCTTCAGG ACACACTTGA AGCTGCTAGC TTTTTACAAA TATTACCCGT TTTGGATTTC 
TGTAAAGTAT TTCTTATATC AGGAGTCTCT TTGGATAACT GTGTTGAGGT TGGACGAATT 
GCTAACACCT ACAATCTTAT AGAAGTGGAT AAATATGTTA ATAATTTCAT CCTGAAGAAC 
TTTCCTGCTT TATTGAGTAC TGGGGAGTTT CTAAAACTCC CTTTTGAACG ACTTGCATTT 
GTGCTTTCCA GTAATAGTCT TAAGCACTGT ACCGAACTTG AACTCTTTAA GGCAGCCTGT 
CGCTGGCTAA GGTTGGAAGA CCCTCGGATG GATTATGCTG CAAAGTTAAT GAAGAATATT 
CGATTTCCAC TGATGACACC ACAGGATCTC ATCAATTACG TGCAGACAGT AGATTTCATG 
AGAACAGACA ATACCTGCGT GAATTTGCTT TTGGAAGCTA GCAATTACCA AATGATGCCA 
TATATGCAGC CAGTGATGCA GTCAGATAGA ACTGCCATTC GATCTGACTC CACTCACTTG 
GTTACATTAG GAGGAGTTTT GAGGCAGCAG CTGGTTGTCA GTAAAGAATT ACGGATGTAT 
GATGAAAGGG CACAAGAATG GAGATCTTTA GCCCCAATGG ATGCTCCCCG TTACCAGCAT 
GGTATTGCTG TCATTGGAAA CTTTCTTTAT GTAGTTGGTG GTCAGAGTAA TTATGATACA 
AAAGGAAAAA CTGCTGTTGA TACAGTTTTC AGATTTGATC CTCGGTATAA TAAATGGATG 
CAGGTTGCAT CATTAAATGA AAAGCGCACA TTCTTTCACT TGAGTGCCCT CAAAGGACAT 
TTGTATGCAG TTGGTGGGCG CAGTGCAGCT GGTGAACTGG CCACAGTAGA ATGTTACAAC 
CCAAGAATGA ATGAGTGGAG CTATGTTGCA AAAATGAGTG AACCCCACTA TGGTCATGCT 
GGAACAGTAT ATGGAGGCTT AATGTATATT TCAGGAGGAA TTACCCATGA CACTTTCCAA 
AATGAGCTCA TGTGTTTTGA CCCAGATACA GATAAATGGA TGCAAAAGGC TCCAATGACT 
ACAGTCAGAG GTCTGCATTG CATGTGTACA GTTGGAGATA AGCTCTATGT CATTGGTGGC 
AATCACTTCA GAGGAACAAG TGATTATGAT GATGTTCTAA GCTGTGAATA CTATTCACCA 
ACCCTTGACC AGTGGACCCC AATTGCCGCC ATGTTAAGAG GCCAAAGTGA TGTTGGAGTT 
GCCGTCTTTG AAAATAAAAT CTATGTTGTT GGTGGATATT CTTGGAATAA TCGTTGTATG 
GTAGAAATTG TCCAGAAATA TGACCCAGAA AAAGATGAGT GGCATAAAGT TTTTGATCTT 
CCAGAGTCAC TTGGTGGCAT TCGAGCCTGT ACACTCACAG TTTTTCCACC TGAAGAAAAC 
CCTGGGTCAC CTTCTAGAGA ATCACCTCTT TCAGCACCTT CAGATCATTC TTAG

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

PubMed

Update on the Kelch-like (KLHL) gene family.
Human genomics713(2013 May)
Dhanoa BS,Cogliati T,Satish AG,Bruford EA,Friedman JS

Associations of 9p21 variants with cutaneous malignant melanoma, nevi, and pigmentation phenotypes in melanoma-prone families with and without CDKN2A mutations.
Familial cancer9(4)625-33(2010 Dec)
Yang XR,Liang X,Pfeiffer RM,Wheeler W,Maeder D,Burdette L,Yeager M,Chanock S,Tucker MA,Goldstein AM

Kelch-like homologue 9 mutation is associated with an early onset autosomal dominant distal myopathy.
Brain : a journal of neurology133(Pt 7)2123-35(2010 Jul)
Cirak S,von Deimling F,Sachdev S,Errington WJ,Herrmann R,B?nnemann C,Brockmann K,Hinderlich S,Lindner TH,Steinbrecher A,Hoffmann K,Priv? GG,Hannink M,N?rnberg P,Voit T

The Cul3-KLHL21 E3 ubiquitin ligase targets aurora B to midzone microtubules in anaphase and is required for cytokinesis.
The Journal of cell biology187(6)791-800(2009 Dec)
Maerki S,Olma MH,Staubli T,Steigemann P,Gerlich DW,Quadroni M,Sumara I,Peter M

A Cul3-based E3 ligase removes Aurora B from mitotic chromosomes, regulating mitotic progression and completion of cytokinesis in human cells.
Developmental cell12(6)887-900(2007 Jun)
Sumara I,Quadroni M,Frei C,Olma MH,Sumara G,Ricci R,Peter M

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KLHL9 cDNA ORF clone, Homo sapiens(Human)

Gene

Clones

gRNAs

Related articles in PubMed

Target ORF information:

Target ORF information:

ORF Insert Sequence:

Target ORF information:

Target ORF information:

ORF Insert Sequence:

Target ORF information:

Target ORF information:

ORF Insert Sequence:

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