LANCL2 cDNA ORF clone, Homo sapiens(human)

G-protein coupling and nuclear translocation of the human abscisic acid receptor LANCL2.
Fresia C, Vigliarolo T, Guida L, Booz V, Bruzzone S, Sturla L, Di Bona M, Pesce M, Usai C, De Flora A, Zocchi E
Scientific reports626658(2016 May)

Lanthionine synthetase C-like protein 2 (LanCL2) is a novel regulator of Akt.
Zeng M, van der Donk WA, Chen J
Molecular biology of the cell25(24)3954-61(2014 Dec)

Binding of abscisic acid to human LANCL2.
Sturla L, Fresia C, Guida L, Grozio A, Vigliarolo T, Mannino E, Millo E, Bagnasco L, Bruzzone S, De Flora A, Zocchi E
Biochemical and biophysical research communications415(2)390-5(2011 Nov)

Proteomic characterization of the human sperm nucleus.
de Mateo S, Castillo J, Estanyol JM, Ballesc? JL, Oliva R
Proteomics11(13)2714-26(2011 Jul)

Data indicate that lanthionine synthetase C-like 2 (LanCL2) depletion sensitizes cells to apoptosis through down-regulating serine/threonine protein kinase Akt phosphorylation.
Title: Lanthionine synthetase C-like protein 2 (LanCL2) is a novel regulator of Akt.

human recombinant LANCL2 binds abscisic acid (ABA) directly and provide the first demonstration of ABA binding to a mammalian ABA receptor.
Title: Binding of abscisic acid to human LANCL2.

Molecular docking studies predict that ABA and other PPAR gamma agonists (e.g., rosiglitazone and pioglitazone) share a binding site on the surface of LANCL2.
Title: Molecular modeling of lanthionine synthetase component C-like protein 2: a potential target for the discovery of novel type 2 diabetes prophylactics and therapeutics.

Data show that lanthionine synthetase C-like protein (LANCL2) is required for abscisic acid binding on human granulocyte membranes and that LANCL2 is necessary for transduction of the ABA signal into granulocytes and rat insulinoma cells.
Title: LANCL2 is necessary for abscisic acid binding and signaling in human granulocytes and in rat insulinoma cells.

Using shotgun mass spectrometry, we found this protein differentially expressed in the dorsolateral prefrontal cortex from patients with schizophrenia.
Title: Prefrontal cortex shotgun proteome analysis reveals altered calcium homeostasis and immune system imbalance in schizophrenia.