DOK5 cDNA ORF clone, Homo sapiens(human)

Gene
Clones
gRNAs

Summary

Gene Symbol	DOK5
Entrez Gene ID	55816
Full Name	docking protein 5
Synonyms	C20orf180,IRS-6,IRS6
General protein information	Preferred Names docking protein 5 Names docking protein 5 downstream of tyrosine kinase 5 insulin receptor substrate 6
Gene Type	protein-coding
Organism	Homo sapiens(human)
Genome	Chromosome: 20 Map Location: 20q13.2
Summary	The protein encoded by this gene is a member of the DOK family of membrane proteins, which are adapter proteins involved in signal transduction. The encoded protein interacts with phosphorylated receptor tyrosine kinases to mediate neurite outgrowth and activation of the MAP kinase pathway. Unlike other DOK family proteins, this protein does not interact with RASGAP. This protein is up-regulated in patients with systemic sclerosis and is associated with fibrosis induced by insulin-like growth factor binding protein 5. Alternative splicing of this gene results in multiple transcript variants. [provided by RefSeq, Jun 2014].
Disorder MIM:	608334

mRNA and Protein(s)

mRNA	Protein	Name
NM_001294161.1	NP_001281090.1	docking protein 5 isoform c
NM_001294161.2	NP_001281090.1	docking protein 5 isoform c
XM_024451946.1	XP_024307714.1	docking protein 5 isoform X1
NM_018431.5	NP_060901.2	docking protein 5 isoform a
XM_011528904.1	XP_011527206.1	docking protein 5 isoform X2
NM_177959.3	NP_808874.1	docking protein 5 isoform b
NM_177959.2	NP_808874.1	docking protein 5 isoform b
NM_018431.4	NP_060901.2	docking protein 5 isoform a

Pathways from BioSystems

Homologies

	DOK5	XP_001091477.1
Mus musculus (house mouse)	Dok5	NP_001157158.1
Xenopus tropicalis (tropical clawed frog)	dok5	XP_002935431.1
Pan troglodytes (chimpanzee)	DOK5	XP_001169643.1
Canis lupus familiaris (dog)	DOK5	XP_005635248.1
Homo sapiens (human)	DOK5	NP_060901.2
Rattus norvegicus (Norway rat)	Dok5	NP_001102814.1
Bos taurus (cattle)	DOK5	NP_001069407.1
Gallus gallus (chicken)	DOK5	XP_417502.2

Gene Ontology
Bibliography

Related articles in PubMed

The membrane-associated adaptor protein DOK5 is upregulated in systemic sclerosis and associated with IGFBP-5-induced fibrosis.
Yasuoka H, Yamaguchi Y, Feghali-Bostwick CA
PloS one9(2)e87754(2014)

Dok5 is involved in the signaling pathway of neurotrophin-3 against TrkC-induced apoptosis.
Pan Y, Zhang J, Liu W, Shu P, Yin B, Yuan J, Qiang B, Peng X
Neuroscience letters55346-51(2013 Oct)

Genetic analysis of 16 NMR-lipoprotein fractions in humans, the GOLDN study.
Kraja AT, Borecki IB, Tsai MY, Ordovas JM, Hopkins PN, Lai CQ, Frazier-Wood AC, Straka RJ, Hixson JE, Province MA, Arnett DK
Lipids48(2)155-65(2013 Feb)

A possible mechanism behind autoimmune disorders discovered by genome-wide linkage and association analysis in celiac disease.
?stensson M, Mont?n C, Bacelis J, Gudjonsdottir AH, Adamovic S, Ek J, Ascher H, Pollak E, Arnell H, Browaldh L, Agardh D, Wahlstr?m J, Nilsson S, Torinsson-Naluai ?
PloS one8(8)e70174(2013)

Mapping the structural topology of IRS family cascades through computational biology.
Chakraborty C, Doss CG, Bandyopadhyay S, Sarkar BK, Haneef SA
Cell biochemistry and biophysics67(3)1319-31(2013)

GeneRIFs: Gene References Into Functions What's a GeneRIF?

IGFBP-5 induces its pro-fibrotic effects, at least in part, via DOK5. IGFBP-5 and DOK5 are both increased in systemic sclerosis fibroblasts and tissues and may thus be acting in concert to promote fibrosis.
Title: The membrane-associated adaptor protein DOK5 is upregulated in systemic sclerosis and associated with IGFBP-5-induced fibrosis.

Observational study of gene-disease association. (HuGE Navigator)
Title: A large-scale candidate gene association study of age at menarche and age at natural menopause.

Observational study of gene-disease association. (HuGE Navigator)
Title: Evaluation of DOK5 as a susceptibility gene for type 2 diabetes and obesity in North Indian population.

Although preliminary, these data suggest that DOK5 and perhaps several other genes influence the magnitude of amygdala activation during face processing, particularly in those with BD.
Title: A genome-wide association study of amygdala activation in youths with and without bipolar disorder.

IRS5/DOK4 and IRS6/DOK5 represent two new signaling proteins with potential roles in insulin and IGF-1 action
Title: Two new substrates in insulin signaling, IRS5/DOK4 and IRS6/DOK5.

The following DOK5 gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the DOK5 cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1⁺/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.

***CloneID	Accession No.	Definition	**Vector	*Turnaround time	Price (USD)
OHu28498	NM_177959.3 Latest version!	Homo sapiens docking protein 5 (DOK5), transcript variant 2, mRNA.	pcDNA3.1-C-(k)DYK or customized vector	in pcDNA3.1-C-(k)DYK	$49.50-$69.30 $99.00
OHu28498	XM_011528904.1 Latest version!	Homo sapiens docking protein 5 (DOK5), transcript variant X2, mRNA.	pcDNA3.1-C-(k)DYK or customized vector	in pcDNA3.1-C-(k)DYK	$49.50-$69.30 $99.00
OHu28671	NM_018431.5 Latest version!	Homo sapiens docking protein 5 (DOK5), transcript variant 1, mRNA.	pcDNA3.1-C-(k)DYK or customized vector	7-9	$139.30 $199.00
OHu28672	NM_001294161.2 Latest version!	Homo sapiens docking protein 5 (DOK5), transcript variant 3, mRNA.	pcDNA3.1-C-(k)DYK or customized vector	7-9	$69.30 $99.00
OHu69830	XM_024451946.1 Latest version!	Homo sapiens docking protein 5 (DOK5), transcript variant X1, mRNA.	pcDNA3.1-C-(k)DYK or customized vector	9-11	$139.30 $199.00
View Old Accession Versions >>
OHu28672	NM_001294161.1	Homo sapiens docking protein 5 (DOK5), transcript variant 3, mRNA.	pcDNA3.1-C-(k)DYK or customized vector	7-9	$69.30 $99.00
OHu28498	NM_177959.2	Homo sapiens docking protein 5 (DOK5), transcript variant 2, mRNA.	pcDNA3.1-C-(k)DYK or customized vector	in pcDNA3.1-C-(k)DYK	$49.50-$69.30 $99.00
OHu28671	NM_018431.4	Homo sapiens docking protein 5 (DOK5), transcript variant 1, mRNA.	pcDNA3.1-C-(k)DYK or customized vector	7-9	$139.30 $199.00
Hide Old Accession Versions >>

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***One clone ID might be correlated to multiple accession numbers, which share the same CDS sequence.

Reference Sequences (Refseq)

DOK5 ( NM_177959.3 ) cDNA ORF clone, Homo sapiens(human) -> NP_808874.1 Homo sapiens docking protein 5 (DOK5), transcript variant 2, mRNA.

Price & Availability↑

CloneID	OHu28498
Clone ID Related Accession (Same CDS sequence)	XM_011528904.1 , NM_177959.3 , NM_177959.2
Accession Version	NM_177959.3 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 597bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-08-06
Organism	Homo sapiens(human)
Product	docking protein 5 isoform b
Comment	Comment: REVIEWED REFSEQ: This record has been curated by NCBI staff. The reference sequence was derived from AL162292.20, BC008992.1 and BI916998.1. On May 31, 2019 this sequence version replaced NM_177959.2. Transcript Variant: This variant (2) contains an alternate 5' terminal exon, and it thus differs in its 5' UTR, lacks a portion of the 5' coding region, and initiates translation at a downstream in-frame start codon, compared to variant 1. The encoded isoform (b) is shorter at the N-terminus, compared to isoform a. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: BC008992.1 [ECO:0000332] ##Evidence-Data-END## COMPLETENESS: complete on the 3' end.

ATGGAGTGTG TAGGAACACG GATCAATGAC ATCAGCCTTG GAGAGCCTGA CTTACTGGCC 
ACTGGGGTTG AGAGAGAACA GAGTGAGAGA TTCAATGTGT ATTTGATGCC ATCTCCTAAC 
TTAGATGTAC ATGGCGAATG TGCCTTGCAG ATTACATATG AGTATATCTG TCTTTGGGAC 
GTCCAGAATC CCAGAGTCAA ACTCATCTCT TGGCCGCTAA GCGCCCTGCG GCGGTATGGA 
CGTGATACTA CGTGGTTCAC TTTTGAGGCA GGGAGGATGT GTGAGACTGG TGAAGGGCTG 
TTTATCTTTC AGACCCGAGA CGGGGAGGCC ATCTATCAGA AAGTCCACTC TGCTGCCTTG 
GCCATAGCCG AGCAGCACGA GCGCTTGCTA CAGAGTGTGA AAAACTCGAT GCTCCAGATG 
AAGATGAGTG AGCGGGCCGC CTCGCTGAGC ACCATGGTGC CCCTGCCTCG CAGCGCCTAC 
TGGCAGCACA TCACACGGCA GCACAGCACG GGACAGCTCT ACCGCTTGCA AGATGTTTCC 
AGCCCTCTGA AGCTTCATCG AACAGAGACT TTTCCAGCCT ACAGATCTGA GCACTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_808874.1
CDS	571..1167
Translation	MECVGTRINDISLGEPDLLATGVEREQSERFNVYLMPSPNLDVHGECALQITYEYICLWDVQNPRVKLISWPLSALRRYGRDTTWFTFEAGRMCETGEGLFIFQTRDGEAIYQKVHSAALAIAEQHERLLQSVKNSMLQMKMSERAASLSTMVPLPRSAYWQHITRQHSTGQLYRLQDVSSPLKLHRTETFPAYRSEH

Target ORF information:

RefSeq Version	NM_177959.3
Organism	Homo sapiens(human)
Definition	Homo sapiens docking protein 5 (DOK5), transcript variant 2, mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_177959.3

ORF Insert Sequence:

ATGGAGTGTG TAGGAACACG GATCAATGAC ATCAGCCTTG GAGAGCCTGA CTTACTGGCC 
ACTGGGGTTG AGAGAGAACA GAGTGAGAGA TTCAATGTGT ATTTGATGCC ATCTCCTAAC 
TTAGATGTAC ATGGCGAATG TGCCTTGCAG ATTACATATG AGTATATCTG TCTTTGGGAC 
GTCCAGAATC CCAGAGTCAA ACTCATCTCT TGGCCGCTAA GCGCCCTGCG GCGGTATGGA 
CGTGATACTA CGTGGTTCAC TTTTGAGGCA GGGAGGATGT GTGAGACTGG TGAAGGGCTG 
TTTATCTTTC AGACCCGAGA CGGGGAGGCC ATCTATCAGA AAGTCCACTC TGCTGCCTTG 
GCCATAGCCG AGCAGCACGA GCGCTTGCTA CAGAGTGTGA AAAACTCGAT GCTCCAGATG 
AAGATGAGTG AGCGGGCCGC CTCGCTGAGC ACCATGGTGC CCCTGCCTCG CAGCGCCTAC 
TGGCAGCACA TCACACGGCA GCACAGCACG GGACAGCTCT ACCGCTTGCA AGATGTTTCC 
AGCCCTCTGA AGCTTCATCG AACAGAGACT TTTCCAGCCT ACAGATCTGA GCACTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

DOK5 ( NM_177959.2 ) cDNA ORF clone, Homo sapiens(human) -> NP_808874.1 Homo sapiens docking protein 5 (DOK5), transcript variant 2, mRNA.

Price & Availability↑

CloneID	OHu28498
Clone ID Related Accession (Same CDS sequence)	XM_011528904.1 , NM_177959.3 , NM_177959.2
Accession Version	NM_177959.2	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 597bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-01-11
Organism	Homo sapiens(human)
Product	docking protein 5 isoform b
Comment	Comment: REVIEWED REFSEQ: This record has been curated by NCBI staff. The reference sequence was derived from BC008992.1 and BI916998.1. On or before Jun 25, 2014 this sequence version replaced XM_005260451.1, NM_177959.1. Transcript Variant: This variant (2) contains an alternate 5' terminal exon, and it thus differs in its 5' UTR, lacks a portion of the 5' coding region, and initiates translation at a downstream in-frame start codon, compared to variant 1. The encoded isoform (b) is shorter at the N-terminus, compared to isoform a. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: BC008992.1 [ECO:0000332] ##Evidence-Data-END## COMPLETENESS: complete on the 3' end.

ATGGAGTGTG TAGGAACACG GATCAATGAC ATCAGCCTTG GAGAGCCTGA CTTACTGGCC 
ACTGGGGTTG AGAGAGAACA GAGTGAGAGA TTCAATGTGT ATTTGATGCC ATCTCCTAAC 
TTAGATGTAC ATGGCGAATG TGCCTTGCAG ATTACATATG AGTATATCTG TCTTTGGGAC 
GTCCAGAATC CCAGAGTCAA ACTCATCTCT TGGCCGCTAA GCGCCCTGCG GCGGTATGGA 
CGTGATACTA CGTGGTTCAC TTTTGAGGCA GGGAGGATGT GTGAGACTGG TGAAGGGCTG 
TTTATCTTTC AGACCCGAGA CGGGGAGGCC ATCTATCAGA AAGTCCACTC TGCTGCCTTG 
GCCATAGCCG AGCAGCACGA GCGCTTGCTA CAGAGTGTGA AAAACTCGAT GCTCCAGATG 
AAGATGAGTG AGCGGGCCGC CTCGCTGAGC ACCATGGTGC CCCTGCCTCG CAGCGCCTAC 
TGGCAGCACA TCACACGGCA GCACAGCACG GGACAGCTCT ACCGCTTGCA AGATGTTTCC 
AGCCCTCTGA AGCTTCATCG AACAGAGACT TTTCCAGCCT ACAGATCTGA GCACTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_808874.1
CDS	446..1042
Translation	MECVGTRINDISLGEPDLLATGVEREQSERFNVYLMPSPNLDVHGECALQITYEYICLWDVQNPRVKLISWPLSALRRYGRDTTWFTFEAGRMCETGEGLFIFQTRDGEAIYQKVHSAALAIAEQHERLLQSVKNSMLQMKMSERAASLSTMVPLPRSAYWQHITRQHSTGQLYRLQDVSSPLKLHRTETFPAYRSEH

Target ORF information:

RefSeq Version	NM_177959.2
Organism	Homo sapiens(human)
Definition	Homo sapiens docking protein 5 (DOK5), transcript variant 2, mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_177959.2

ORF Insert Sequence:

ATGGAGTGTG TAGGAACACG GATCAATGAC ATCAGCCTTG GAGAGCCTGA CTTACTGGCC 
ACTGGGGTTG AGAGAGAACA GAGTGAGAGA TTCAATGTGT ATTTGATGCC ATCTCCTAAC 
TTAGATGTAC ATGGCGAATG TGCCTTGCAG ATTACATATG AGTATATCTG TCTTTGGGAC 
GTCCAGAATC CCAGAGTCAA ACTCATCTCT TGGCCGCTAA GCGCCCTGCG GCGGTATGGA 
CGTGATACTA CGTGGTTCAC TTTTGAGGCA GGGAGGATGT GTGAGACTGG TGAAGGGCTG 
TTTATCTTTC AGACCCGAGA CGGGGAGGCC ATCTATCAGA AAGTCCACTC TGCTGCCTTG 
GCCATAGCCG AGCAGCACGA GCGCTTGCTA CAGAGTGTGA AAAACTCGAT GCTCCAGATG 
AAGATGAGTG AGCGGGCCGC CTCGCTGAGC ACCATGGTGC CCCTGCCTCG CAGCGCCTAC 
TGGCAGCACA TCACACGGCA GCACAGCACG GGACAGCTCT ACCGCTTGCA AGATGTTTCC 
AGCCCTCTGA AGCTTCATCG AACAGAGACT TTTCCAGCCT ACAGATCTGA GCACTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

DOK5 ( XM_011528904.1 ) cDNA ORF clone, Homo sapiens(human) -> XP_011527206.1 Homo sapiens docking protein 5 (DOK5), transcript variant X2, mRNA.

Price & Availability↑

CloneID	OHu28498
Clone ID Related Accession (Same CDS sequence)	XM_011528904.1 , NM_177959.3 , NM_177959.2
Accession Version	XM_011528904.1 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 597bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-12-05
Organism	Homo sapiens(human)
Product	docking protein 5 isoform X2
Comment	Comment: MODEL REFSEQ: This record is predicted by automated computational analysis. This record is derived from a genomic sequence (NC_000020.11) annotated using gene prediction method: Gnomon, supported by EST evidence. Also see: Documentation of NCBI's Annotation Process ##Genome-Annotation-Data-START## Annotation Provider :: NCBI Annotation Status :: Updated annotation Annotation Name :: Homo sapiens Updated Annotation Release 109.20191205 Annotation Version :: 109.20191205 Annotation Pipeline :: NCBI eukaryotic genome annotation pipeline Annotation Software Version :: 8.3 Annotation Method :: Best-placed RefSeq; propagated RefSeq model Features Annotated :: Gene; mRNA; CDS; ncRNA ##Genome-Annotation-Data-END##

ATGGAGTGTG TAGGAACACG GATCAATGAC ATCAGCCTTG GAGAGCCTGA CTTACTGGCC 
ACTGGGGTTG AGAGAGAACA GAGTGAGAGA TTCAATGTGT ATTTGATGCC ATCTCCTAAC 
TTAGATGTAC ATGGCGAATG TGCCTTGCAG ATTACATATG AGTATATCTG TCTTTGGGAC 
GTCCAGAATC CCAGAGTCAA ACTCATCTCT TGGCCGCTAA GCGCCCTGCG GCGGTATGGA 
CGTGATACTA CGTGGTTCAC TTTTGAGGCA GGGAGGATGT GTGAGACTGG TGAAGGGCTG 
TTTATCTTTC AGACCCGAGA CGGGGAGGCC ATCTATCAGA AAGTCCACTC TGCTGCCTTG 
GCCATAGCCG AGCAGCACGA GCGCTTGCTA CAGAGTGTGA AAAACTCGAT GCTCCAGATG 
AAGATGAGTG AGCGGGCCGC CTCGCTGAGC ACCATGGTGC CCCTGCCTCG CAGCGCCTAC 
TGGCAGCACA TCACACGGCA GCACAGCACG GGACAGCTCT ACCGCTTGCA AGATGTTTCC 
AGCCCTCTGA AGCTTCATCG AACAGAGACT TTTCCAGCCT ACAGATCTGA GCACTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	XP_011527206.1
CDS	429..1025
Translation	MECVGTRINDISLGEPDLLATGVEREQSERFNVYLMPSPNLDVHGECALQITYEYICLWDVQNPRVKLISWPLSALRRYGRDTTWFTFEAGRMCETGEGLFIFQTRDGEAIYQKVHSAALAIAEQHERLLQSVKNSMLQMKMSERAASLSTMVPLPRSAYWQHITRQHSTGQLYRLQDVSSPLKLHRTETFPAYRSEH

Target ORF information:

RefSeq Version	XM_011528904.1
Organism	Homo sapiens(human)
Definition	Homo sapiens docking protein 5 (DOK5), transcript variant X2, mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

XM_011528904.1

ORF Insert Sequence:

ATGGAGTGTG TAGGAACACG GATCAATGAC ATCAGCCTTG GAGAGCCTGA CTTACTGGCC 
ACTGGGGTTG AGAGAGAACA GAGTGAGAGA TTCAATGTGT ATTTGATGCC ATCTCCTAAC 
TTAGATGTAC ATGGCGAATG TGCCTTGCAG ATTACATATG AGTATATCTG TCTTTGGGAC 
GTCCAGAATC CCAGAGTCAA ACTCATCTCT TGGCCGCTAA GCGCCCTGCG GCGGTATGGA 
CGTGATACTA CGTGGTTCAC TTTTGAGGCA GGGAGGATGT GTGAGACTGG TGAAGGGCTG 
TTTATCTTTC AGACCCGAGA CGGGGAGGCC ATCTATCAGA AAGTCCACTC TGCTGCCTTG 
GCCATAGCCG AGCAGCACGA GCGCTTGCTA CAGAGTGTGA AAAACTCGAT GCTCCAGATG 
AAGATGAGTG AGCGGGCCGC CTCGCTGAGC ACCATGGTGC CCCTGCCTCG CAGCGCCTAC 
TGGCAGCACA TCACACGGCA GCACAGCACG GGACAGCTCT ACCGCTTGCA AGATGTTTCC 
AGCCCTCTGA AGCTTCATCG AACAGAGACT TTTCCAGCCT ACAGATCTGA GCACTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

DOK5 ( NM_018431.5 ) cDNA ORF clone, Homo sapiens(human) -> NP_060901.2 Homo sapiens docking protein 5 (DOK5), transcript variant 1, mRNA.

Price & Availability↑

CloneID	OHu28671
Clone ID Related Accession (Same CDS sequence)	NM_018431.5 , NM_018431.4
Accession Version	NM_018431.5 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 921bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2020-01-01
Organism	Homo sapiens(human)
Product	docking protein 5 isoform a
Comment	Comment: REVIEWED REFSEQ: This record has been curated by NCBI staff. The reference sequence was derived from DA161365.1, AF466368.1, AF132732.1 and CN427887.1. On May 17, 2019 this sequence version replaced NM_018431.4. Transcript Variant: This variant (1) represents the longest transcript and encodes the longest isoform (a). Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: SRR7410570.679472.1, SRR7410570.679471.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA1968540, SAMEA2142853 [ECO:0000348] ##Evidence-Data-END## ##RefSeq-Attributes-START## MANE Ensembl match :: ENST00000262593.10/ ENSP00000262593.5 RefSeq Select criteria :: based on conservation, expression, longest protein ##RefSeq-Attributes-END## COMPLETENESS: complete on the 3' end.

ATGGCTTCCA ATTTTAATGA CATAGTGAAG CAAGGGTACG TGAGGATCCG GAGCAGACGC 
CTCGGGATTT ATCAGCGATG CTGGTTAGTA TTCAAGAAAG CTTCAAGCAA AGGTCCAAAA 
AGACTGGAGA AATTTTCTGA TGAACGTGCT GCATATTTCA GGTGTTATCA TAAGGTTACA 
GAACTCAATA ATGTGAAGAA CGTAGCTCGA TTGCCAAAAA GCACCAAGAA ACATGCCATA 
GGGATTTATT TCAATGACGA TACCTCCAAG ACTTTTGCTT GCGAATCAGA TCTTGAGGCT 
GATGAGTGGT GCAAAGTACT CCAGATGGAG TGTGTAGGAA CACGGATCAA TGACATCAGC 
CTTGGAGAGC CTGACTTACT GGCCACTGGG GTTGAGAGAG AACAGAGTGA GAGATTCAAT 
GTGTATTTGA TGCCATCTCC TAACTTAGAT GTACATGGCG AATGTGCCTT GCAGATTACA 
TATGAGTATA TCTGTCTTTG GGACGTCCAG AATCCCAGAG TCAAACTCAT CTCTTGGCCG 
CTAAGCGCCC TGCGGCGGTA TGGACGTGAT ACTACGTGGT TCACTTTTGA GGCAGGGAGG 
ATGTGTGAGA CTGGTGAAGG GCTGTTTATC TTTCAGACCC GAGACGGGGA GGCCATCTAT 
CAGAAAGTCC ACTCTGCTGC CTTGGCCATA GCCGAGCAGC ACGAGCGCTT GCTACAGAGT 
GTGAAAAACT CGATGCTCCA GATGAAGATG AGTGAGCGGG CCGCCTCGCT GAGCACCATG 
GTGCCCCTGC CTCGCAGCGC CTACTGGCAG CACATCACAC GGCAGCACAG CACGGGACAG 
CTCTACCGCT TGCAAGATGT TTCCAGCCCT CTGAAGCTTC ATCGAACAGA GACTTTTCCA 
GCCTACAGAT CTGAGCACTG A

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_060901.2
CDS	355..1275
Translation	MASNFNDIVKQGYVRIRSRRLGIYQRCWLVFKKASSKGPKRLEKFSDERAAYFRCYHKVTELNNVKNVARLPKSTKKHAIGIYFNDDTSKTFACESDLEADEWCKVLQMECVGTRINDISLGEPDLLATGVEREQSERFNVYLMPSPNLDVHGECALQITYEYICLWDVQNPRVKLISWPLSALRRYGRDTTWFTFEAGRMCETGEGLFIFQTRDGEAIYQKVHSAALAIAEQHERLLQSVKNSMLQMKMSERAASLSTMVPLPRSAYWQHITRQHSTGQLYRLQDVSSPLKLHRTETFPAYRSEH

Target ORF information:

RefSeq Version	NM_018431.5
Organism	Homo sapiens(human)
Definition	Homo sapiens docking protein 5 (DOK5), transcript variant 1, mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_018431.5

ORF Insert Sequence:

ATGGCTTCCA ATTTTAATGA CATAGTGAAG CAAGGGTACG TGAGGATCCG GAGCAGACGC 
CTCGGGATTT ATCAGCGATG CTGGTTAGTA TTCAAGAAAG CTTCAAGCAA AGGTCCAAAA 
AGACTGGAGA AATTTTCTGA TGAACGTGCT GCATATTTCA GGTGTTATCA TAAGGTTACA 
GAACTCAATA ATGTGAAGAA CGTAGCTCGA TTGCCAAAAA GCACCAAGAA ACATGCCATA 
GGGATTTATT TCAATGACGA TACCTCCAAG ACTTTTGCTT GCGAATCAGA TCTTGAGGCT 
GATGAGTGGT GCAAAGTACT CCAGATGGAG TGTGTAGGAA CACGGATCAA TGACATCAGC 
CTTGGAGAGC CTGACTTACT GGCCACTGGG GTTGAGAGAG AACAGAGTGA GAGATTCAAT 
GTGTATTTGA TGCCATCTCC TAACTTAGAT GTACATGGCG AATGTGCCTT GCAGATTACA 
TATGAGTATA TCTGTCTTTG GGACGTCCAG AATCCCAGAG TCAAACTCAT CTCTTGGCCG 
CTAAGCGCCC TGCGGCGGTA TGGACGTGAT ACTACGTGGT TCACTTTTGA GGCAGGGAGG 
ATGTGTGAGA CTGGTGAAGG GCTGTTTATC TTTCAGACCC GAGACGGGGA GGCCATCTAT 
CAGAAAGTCC ACTCTGCTGC CTTGGCCATA GCCGAGCAGC ACGAGCGCTT GCTACAGAGT 
GTGAAAAACT CGATGCTCCA GATGAAGATG AGTGAGCGGG CCGCCTCGCT GAGCACCATG 
GTGCCCCTGC CTCGCAGCGC CTACTGGCAG CACATCACAC GGCAGCACAG CACGGGACAG 
CTCTACCGCT TGCAAGATGT TTCCAGCCCT CTGAAGCTTC ATCGAACAGA GACTTTTCCA 
GCCTACAGAT CTGAGCACTG A

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

DOK5 ( NM_018431.4 ) cDNA ORF clone, Homo sapiens(human) -> NP_060901.2 Homo sapiens docking protein 5 (DOK5), transcript variant 1, mRNA.

Price & Availability↑

CloneID	OHu28671
Clone ID Related Accession (Same CDS sequence)	NM_018431.5 , NM_018431.4
Accession Version	NM_018431.4	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 921bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-01-11
Organism	Homo sapiens(human)
Product	docking protein 5 isoform a
Comment	Comment: REVIEWED REFSEQ: This record has been curated by NCBI staff. The reference sequence was derived from DA161365.1, AF466368.1, AF132732.1 and CN427887.1. On Jun 26, 2014 this sequence version replaced NM_018431.3. Transcript Variant: This variant (1) represents the longest transcript and encodes the longest isoform (a). Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: SRR1660803.93495.1, SRR1803616.269721.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA1968540, SAMEA2142853 [ECO:0000348] ##Evidence-Data-END## COMPLETENESS: complete on the 3' end.

ATGGCTTCCA ATTTTAATGA CATAGTGAAG CAAGGGTACG TGAGGATCCG GAGCAGACGC 
CTCGGGATTT ATCAGCGATG CTGGTTAGTA TTCAAGAAAG CTTCAAGCAA AGGTCCAAAA 
AGACTGGAGA AATTTTCTGA TGAACGTGCT GCATATTTCA GGTGTTATCA TAAGGTTACA 
GAACTCAATA ATGTGAAGAA CGTAGCTCGA TTGCCAAAAA GCACCAAGAA ACATGCCATA 
GGGATTTATT TCAATGACGA TACCTCCAAG ACTTTTGCTT GCGAATCAGA TCTTGAGGCT 
GATGAGTGGT GCAAAGTACT CCAGATGGAG TGTGTAGGAA CACGGATCAA TGACATCAGC 
CTTGGAGAGC CTGACTTACT GGCCACTGGG GTTGAGAGAG AACAGAGTGA GAGATTCAAT 
GTGTATTTGA TGCCATCTCC TAACTTAGAT GTACATGGCG AATGTGCCTT GCAGATTACA 
TATGAGTATA TCTGTCTTTG GGACGTCCAG AATCCCAGAG TCAAACTCAT CTCTTGGCCG 
CTAAGCGCCC TGCGGCGGTA TGGACGTGAT ACTACGTGGT TCACTTTTGA GGCAGGGAGG 
ATGTGTGAGA CTGGTGAAGG GCTGTTTATC TTTCAGACCC GAGACGGGGA GGCCATCTAT 
CAGAAAGTCC ACTCTGCTGC CTTGGCCATA GCCGAGCAGC ACGAGCGCTT GCTACAGAGT 
GTGAAAAACT CGATGCTCCA GATGAAGATG AGTGAGCGGG CCGCCTCGCT GAGCACCATG 
GTGCCCCTGC CTCGCAGCGC CTACTGGCAG CACATCACAC GGCAGCACAG CACGGGACAG 
CTCTACCGCT TGCAAGATGT TTCCAGCCCT CTGAAGCTTC ATCGAACAGA GACTTTTCCA 
GCCTACAGAT CTGAGCACTG A

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_060901.2
CDS	476..1396
Translation	MASNFNDIVKQGYVRIRSRRLGIYQRCWLVFKKASSKGPKRLEKFSDERAAYFRCYHKVTELNNVKNVARLPKSTKKHAIGIYFNDDTSKTFACESDLEADEWCKVLQMECVGTRINDISLGEPDLLATGVEREQSERFNVYLMPSPNLDVHGECALQITYEYICLWDVQNPRVKLISWPLSALRRYGRDTTWFTFEAGRMCETGEGLFIFQTRDGEAIYQKVHSAALAIAEQHERLLQSVKNSMLQMKMSERAASLSTMVPLPRSAYWQHITRQHSTGQLYRLQDVSSPLKLHRTETFPAYRSEH

Target ORF information:

RefSeq Version	NM_018431.4
Organism	Homo sapiens(human)
Definition	Homo sapiens docking protein 5 (DOK5), transcript variant 1, mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_018431.4

ORF Insert Sequence:

ATGGCTTCCA ATTTTAATGA CATAGTGAAG CAAGGGTACG TGAGGATCCG GAGCAGACGC 
CTCGGGATTT ATCAGCGATG CTGGTTAGTA TTCAAGAAAG CTTCAAGCAA AGGTCCAAAA 
AGACTGGAGA AATTTTCTGA TGAACGTGCT GCATATTTCA GGTGTTATCA TAAGGTTACA 
GAACTCAATA ATGTGAAGAA CGTAGCTCGA TTGCCAAAAA GCACCAAGAA ACATGCCATA 
GGGATTTATT TCAATGACGA TACCTCCAAG ACTTTTGCTT GCGAATCAGA TCTTGAGGCT 
GATGAGTGGT GCAAAGTACT CCAGATGGAG TGTGTAGGAA CACGGATCAA TGACATCAGC 
CTTGGAGAGC CTGACTTACT GGCCACTGGG GTTGAGAGAG AACAGAGTGA GAGATTCAAT 
GTGTATTTGA TGCCATCTCC TAACTTAGAT GTACATGGCG AATGTGCCTT GCAGATTACA 
TATGAGTATA TCTGTCTTTG GGACGTCCAG AATCCCAGAG TCAAACTCAT CTCTTGGCCG 
CTAAGCGCCC TGCGGCGGTA TGGACGTGAT ACTACGTGGT TCACTTTTGA GGCAGGGAGG 
ATGTGTGAGA CTGGTGAAGG GCTGTTTATC TTTCAGACCC GAGACGGGGA GGCCATCTAT 
CAGAAAGTCC ACTCTGCTGC CTTGGCCATA GCCGAGCAGC ACGAGCGCTT GCTACAGAGT 
GTGAAAAACT CGATGCTCCA GATGAAGATG AGTGAGCGGG CCGCCTCGCT GAGCACCATG 
GTGCCCCTGC CTCGCAGCGC CTACTGGCAG CACATCACAC GGCAGCACAG CACGGGACAG 
CTCTACCGCT TGCAAGATGT TTCCAGCCCT CTGAAGCTTC ATCGAACAGA GACTTTTCCA 
GCCTACAGAT CTGAGCACTG A

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

DOK5 ( NM_001294161.1 ) cDNA ORF clone, Homo sapiens(human) -> NP_001281090.1 Homo sapiens docking protein 5 (DOK5), transcript variant 3, mRNA.

Price & Availability↑

CloneID	OHu28672
Clone ID Related Accession (Same CDS sequence)	NM_001294161.1 , NM_001294161.2
Accession Version	NM_001294161.1	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 237bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-01-11
Organism	Homo sapiens(human)
Product	docking protein 5 isoform c
Comment	Comment: REVIEWED REFSEQ: This record has been curated by NCBI staff. The reference sequence was derived from DA161365.1, AI822030.1 and BG212868.1. Transcript Variant: This variant (3) shares the same 5' terminal exon, and lacks the remaining exons but contains an alternate 3' terminal exon, and it thus differs in its 3' coding region and 3' UTR, compared to variant 1. The encoded isoform (c) has a distinct C-terminus and is significantly shorter than isoform a. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: AI822030.1, AI792918.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA1968189, SAMEA2142670 [ECO:0000348] ##Evidence-Data-END## COMPLETENESS: complete on the 3' end.

ATGGCTTCCA ATTTTAATGA CATAGTGAAG CAAGGGTACG TGAGGATCCG GAGCAGACGC 
CTCGGGGTGC TGATCCTGAG AGCCCTCCGC AGTGAACACC CTGCATGCAG ATCTCCTTCT 
TGGAACCTGT TCCTGGAAAA CCCAGTCTCC AGCAACCTGA TATGTAACTG CAAATCTGCA 
ACTCTAGACC AACCTTCTAA AGAGGGATTT AAGACCTTTT TCAAGAATCT GGCTTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_001281090.1
CDS	476..712
Translation	MASNFNDIVKQGYVRIRSRRLGVLILRALRSEHPACRSPSWNLFLENPVSSNLICNCKSATLDQPSKEGFKTFFKNLA

Target ORF information:

RefSeq Version	NM_001294161.1
Organism	Homo sapiens(human)
Definition	Homo sapiens docking protein 5 (DOK5), transcript variant 3, mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_001294161.1

ORF Insert Sequence:

ATGGCTTCCA ATTTTAATGA CATAGTGAAG CAAGGGTACG TGAGGATCCG GAGCAGACGC 
CTCGGGGTGC TGATCCTGAG AGCCCTCCGC AGTGAACACC CTGCATGCAG ATCTCCTTCT 
TGGAACCTGT TCCTGGAAAA CCCAGTCTCC AGCAACCTGA TATGTAACTG CAAATCTGCA 
ACTCTAGACC AACCTTCTAA AGAGGGATTT AAGACCTTTT TCAAGAATCT GGCTTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

DOK5 ( NM_001294161.2 ) cDNA ORF clone, Homo sapiens(human) -> NP_001281090.1 Homo sapiens docking protein 5 (DOK5), transcript variant 3, mRNA.

Price & Availability↑

CloneID	OHu28672
Clone ID Related Accession (Same CDS sequence)	NM_001294161.1 , NM_001294161.2
Accession Version	NM_001294161.2 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 237bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-08-06
Organism	Homo sapiens(human)
Product	docking protein 5 isoform c
Comment	Comment: REVIEWED REFSEQ: This record has been curated by NCBI staff. The reference sequence was derived from DA161365.1, AI822030.1 and BG212868.1. On May 31, 2019 this sequence version replaced NM_001294161.1. Transcript Variant: This variant (3) shares the same 5' terminal exon, and lacks the remaining exons but contains an alternate 3' terminal exon, and it thus differs in its 3' coding region and 3' UTR, compared to variant 1. The encoded isoform (c) has a distinct C-terminus and is significantly shorter than isoform a. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: DRR138525.737298.1, AI822030.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA1968189, SAMEA2142670 [ECO:0000348] ##Evidence-Data-END## COMPLETENESS: complete on the 3' end.

ATGGCTTCCA ATTTTAATGA CATAGTGAAG CAAGGGTACG TGAGGATCCG GAGCAGACGC 
CTCGGGGTGC TGATCCTGAG AGCCCTCCGC AGTGAACACC CTGCATGCAG ATCTCCTTCT 
TGGAACCTGT TCCTGGAAAA CCCAGTCTCC AGCAACCTGA TATGTAACTG CAAATCTGCA 
ACTCTAGACC AACCTTCTAA AGAGGGATTT AAGACCTTTT TCAAGAATCT GGCTTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_001281090.1
CDS	355..591
Translation	MASNFNDIVKQGYVRIRSRRLGVLILRALRSEHPACRSPSWNLFLENPVSSNLICNCKSATLDQPSKEGFKTFFKNLA

Target ORF information:

RefSeq Version	NM_001294161.2
Organism	Homo sapiens(human)
Definition	Homo sapiens docking protein 5 (DOK5), transcript variant 3, mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_001294161.2

ORF Insert Sequence:

ATGGCTTCCA ATTTTAATGA CATAGTGAAG CAAGGGTACG TGAGGATCCG GAGCAGACGC 
CTCGGGGTGC TGATCCTGAG AGCCCTCCGC AGTGAACACC CTGCATGCAG ATCTCCTTCT 
TGGAACCTGT TCCTGGAAAA CCCAGTCTCC AGCAACCTGA TATGTAACTG CAAATCTGCA 
ACTCTAGACC AACCTTCTAA AGAGGGATTT AAGACCTTTT TCAAGAATCT GGCTTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

DOK5 ( XM_024451946.1 ) cDNA ORF clone, Homo sapiens(human) -> XP_024307714.1 Homo sapiens docking protein 5 (DOK5), transcript variant X1, mRNA.

Price & Availability↑

CloneID	OHu69830
Clone ID Related Accession (Same CDS sequence)	XM_024451946.1
Accession Version	XM_024451946.1 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 885bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-12-05
Organism	Homo sapiens(human)
Product	docking protein 5 isoform X1
Comment	Comment: MODEL REFSEQ: This record is predicted by automated computational analysis. This record is derived from a genomic sequence (NC_000020.11) annotated using gene prediction method: Gnomon, supported by EST evidence. Also see: Documentation of NCBI's Annotation Process ##Genome-Annotation-Data-START## Annotation Provider :: NCBI Annotation Status :: Updated annotation Annotation Name :: Homo sapiens Updated Annotation Release 109.20191205 Annotation Version :: 109.20191205 Annotation Pipeline :: NCBI eukaryotic genome annotation pipeline Annotation Software Version :: 8.3 Annotation Method :: Best-placed RefSeq; propagated RefSeq model Features Annotated :: Gene; mRNA; CDS; ncRNA ##Genome-Annotation-Data-END##

ATGCTGGACC AAACAGTGAG AATCACTGAG ATTTATCAGC GATGCTGGTT AGTATTCAAG 
AAAGCTTCAA GCAAAGGTCC AAAAAGACTG GAGAAATTTT CTGATGAACG TGCTGCATAT 
TTCAGGTGTT ATCATAAGGT TACAGAACTC AATAATGTGA AGAACGTAGC TCGATTGCCA 
AAAAGCACCA AGAAACATGC CATAGGGATT TATTTCAATG ACGATACCTC CAAGACTTTT 
GCTTGCGAAT CAGATCTTGA GGCTGATGAG TGGTGCAAAG TACTCCAGAT GGAGTGTGTA 
GGAACACGGA TCAATGACAT CAGCCTTGGA GAGCCTGACT TACTGGCCAC TGGGGTTGAG 
AGAGAACAGA GTGAGAGATT CAATGTGTAT TTGATGCCAT CTCCTAACTT AGATGTACAT 
GGCGAATGTG CCTTGCAGAT TACATATGAG TATATCTGTC TTTGGGACGT CCAGAATCCC 
AGAGTCAAAC TCATCTCTTG GCCGCTAAGC GCCCTGCGGC GGTATGGACG TGATACTACG 
TGGTTCACTT TTGAGGCAGG GAGGATGTGT GAGACTGGTG AAGGGCTGTT TATCTTTCAG 
ACCCGAGACG GGGAGGCCAT CTATCAGAAA GTCCACTCTG CTGCCTTGGC CATAGCCGAG 
CAGCACGAGC GCTTGCTACA GAGTGTGAAA AACTCGATGC TCCAGATGAA GATGAGTGAG 
CGGGCCGCCT CGCTGAGCAC CATGGTGCCC CTGCCTCGCA GCGCCTACTG GCAGCACATC 
ACACGGCAGC ACAGCACGGG ACAGCTCTAC CGCTTGCAAG ATGTTTCCAG CCCTCTGAAG 
CTTCATCGAA CAGAGACTTT TCCAGCCTAC AGATCTGAGC ACTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	XP_024307714.1
CDS	312..1196
Translation	MLDQTVRITEIYQRCWLVFKKASSKGPKRLEKFSDERAAYFRCYHKVTELNNVKNVARLPKSTKKHAIGIYFNDDTSKTFACESDLEADEWCKVLQMECVGTRINDISLGEPDLLATGVEREQSERFNVYLMPSPNLDVHGECALQITYEYICLWDVQNPRVKLISWPLSALRRYGRDTTWFTFEAGRMCETGEGLFIFQTRDGEAIYQKVHSAALAIAEQHERLLQSVKNSMLQMKMSERAASLSTMVPLPRSAYWQHITRQHSTGQLYRLQDVSSPLKLHRTETFPAYRSEH

Target ORF information:

RefSeq Version	XM_024451946.1
Organism	Homo sapiens(human)
Definition	Homo sapiens docking protein 5 (DOK5), transcript variant X1, mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

XM_024451946.1

ORF Insert Sequence:

ATGCTGGACC AAACAGTGAG AATCACTGAG ATTTATCAGC GATGCTGGTT AGTATTCAAG 
AAAGCTTCAA GCAAAGGTCC AAAAAGACTG GAGAAATTTT CTGATGAACG TGCTGCATAT 
TTCAGGTGTT ATCATAAGGT TACAGAACTC AATAATGTGA AGAACGTAGC TCGATTGCCA 
AAAAGCACCA AGAAACATGC CATAGGGATT TATTTCAATG ACGATACCTC CAAGACTTTT 
GCTTGCGAAT CAGATCTTGA GGCTGATGAG TGGTGCAAAG TACTCCAGAT GGAGTGTGTA 
GGAACACGGA TCAATGACAT CAGCCTTGGA GAGCCTGACT TACTGGCCAC TGGGGTTGAG 
AGAGAACAGA GTGAGAGATT CAATGTGTAT TTGATGCCAT CTCCTAACTT AGATGTACAT 
GGCGAATGTG CCTTGCAGAT TACATATGAG TATATCTGTC TTTGGGACGT CCAGAATCCC 
AGAGTCAAAC TCATCTCTTG GCCGCTAAGC GCCCTGCGGC GGTATGGACG TGATACTACG 
TGGTTCACTT TTGAGGCAGG GAGGATGTGT GAGACTGGTG AAGGGCTGTT TATCTTTCAG 
ACCCGAGACG GGGAGGCCAT CTATCAGAAA GTCCACTCTG CTGCCTTGGC CATAGCCGAG 
CAGCACGAGC GCTTGCTACA GAGTGTGAAA AACTCGATGC TCCAGATGAA GATGAGTGAG 
CGGGCCGCCT CGCTGAGCAC CATGGTGCCC CTGCCTCGCA GCGCCTACTG GCAGCACATC 
ACACGGCAGC ACAGCACGGG ACAGCTCTAC CGCTTGCAAG ATGTTTCCAG CCCTCTGAAG 
CTTCATCGAA CAGAGACTTT TCCAGCCTAC AGATCTGAGC ACTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

PubMed

The membrane-associated adaptor protein DOK5 is upregulated in systemic sclerosis and associated with IGFBP-5-induced fibrosis.
PloS one9(2)e87754(2014)
Yasuoka H,Yamaguchi Y,Feghali-Bostwick CA

Dok5 is involved in the signaling pathway of neurotrophin-3 against TrkC-induced apoptosis.
Neuroscience letters55346-51(2013 Oct)
Pan Y,Zhang J,Liu W,Shu P,Yin B,Yuan J,Qiang B,Peng X

Genetic analysis of 16 NMR-lipoprotein fractions in humans, the GOLDN study.
Lipids48(2)155-65(2013 Feb)
Kraja AT,Borecki IB,Tsai MY,Ordovas JM,Hopkins PN,Lai CQ,Frazier-Wood AC,Straka RJ,Hixson JE,Province MA,Arnett DK

A possible mechanism behind autoimmune disorders discovered by genome-wide linkage and association analysis in celiac disease.
PloS one8(8)e70174(2013)
?stensson M,Mont?n C,Bacelis J,Gudjonsdottir AH,Adamovic S,Ek J,Ascher H,Pollak E,Arnell H,Browaldh L,Agardh D,Wahlstr?m J,Nilsson S,Torinsson-Naluai ?

Mapping the structural topology of IRS family cascades through computational biology.
Cell biochemistry and biophysics67(3)1319-31(2013)
Chakraborty C,Doss CG,Bandyopadhyay S,Sarkar BK,Haneef SA

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DOK5 cDNA ORF clone, Homo sapiens(human)

Gene

Clones

gRNAs

Related articles in PubMed

Target ORF information:

Target ORF information:

ORF Insert Sequence:

Target ORF information:

Target ORF information:

ORF Insert Sequence:

Target ORF information:

Target ORF information:

ORF Insert Sequence:

Target ORF information:

Target ORF information:

ORF Insert Sequence:

Target ORF information:

Target ORF information:

ORF Insert Sequence:

Target ORF information:

Target ORF information:

ORF Insert Sequence:

Target ORF information:

Target ORF information:

ORF Insert Sequence:

Target ORF information:

Target ORF information:

ORF Insert Sequence:

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