NOP10 cDNA ORF clone, Homo sapiens(human)

Gene
Clones
gRNAs

Summary

Gene Symbol	NOP10
Entrez Gene ID	55505
Full Name	NOP10 ribonucleoprotein
Synonyms	DKCB1,NOLA3,NOP10P
General protein information	Preferred Names NOP10 ribonucleoprotein Names H/ACA ribonucleoprotein complex subunit 3 NOP10 ribonucleoprotein homolog homolog of yeast Nop10p nucleolar protein 10 nucleolar protein family A member 3 nucleolar protein family A, member 3 (H/ACA small nucleolar RNPs) snoRNP protein NOP10
Gene Type	protein-coding
Organism	Homo sapiens(human)
Genome	Chromosome: 15 Map Location: 15q14
Summary	This gene is a member of the H/ACA snoRNPs (small nucleolar ribonucleoproteins) gene family. snoRNPs are involved in various aspects of rRNA processing and modification and have been classified into two families: C/D and H/ACA. The H/ACA snoRNPs also include the DKC1, NOLA1 and NOLA2 proteins. These four H/ACA snoRNP proteins localize to the dense fibrillar components of nucleoli and to coiled (Cajal) bodies in the nucleus. Both 18S rRNA production and rRNA pseudouridylation are impaired if any one of the four proteins is depleted. The four H/ACA snoRNP proteins are also components of the telomerase complex. This gene encodes a protein related to Saccharomyces cerevisiae Nop10p. [provided by RefSeq, Jul 2008].
Disorder MIM:	606471
Disorder Html:	Dyskeratosis congenita, autosomal recessive 1, 224230 (3)

mRNA and Protein(s)

mRNA	Protein	Name
NM_018648.3	NP_061118.1	H/ACA ribonucleoprotein complex subunit 3
NM_018648.4	NP_061118.1	H/ACA ribonucleoprotein complex subunit 3

Pathways from BioSystems

Homologies

Mus musculus (house mouse)	Nop10	NP_079679.1
Anopheles gambiae (African malaria mosquito)	AgaP_AGAP005149	XP_314037.2
Pan troglodytes (chimpanzee)	NOP10	XP_001165824.1
Canis lupus familiaris (dog)	NOP10	XP_849017.2
Bos taurus (cattle)	NOP10	NP_001107993.1
Homo sapiens (human)	NOP10	NP_061118.1
Danio rerio (zebrafish)	nop10	NP_001003868.1
Drosophila melanogaster (fruit fly)	CG7637	NP_610610.1
Rattus norvegicus (Norway rat)	Nop10	NP_001119572.1
Xenopus tropicalis (tropical clawed frog)	nop10	NP_001016163.1

Gene Ontology
Bibliography

Related articles in PubMed

Widespread macromolecular interaction perturbations in human genetic disorders.
Sahni N, Yi S, Taipale M, Fuxman Bass JI, Coulombe-Huntington J, Yang F, Peng J, Weile J, Karras GI, Wang Y, Kov?cs IA, Kamburov A, Krykbaeva I, Lam MH, Tucker G, Khurana V, Sharma A, Liu YY, Yachie N, Zhong Q, Shen Y, Palagi A, San-Miguel A, Fan C, Balcha D, Dricot A, Jordan DM, Walsh JM, Shah AA, Yang X, Stoyanova AK, Leighton A, Calderwood MA, Jacob Y, Cusick ME, Salehi-Ashtiani K, Whitesell LJ, Sunyaev S, Berger B, Barab?si AL, Charloteaux B, Hill DE, Hao T, Roth FP, Xia Y, Walhout AJM, Lindquist S, Vidal M
Cell161(3)647-660(2015 Apr)

Proteostatic control of telomerase function through TRiC-mediated folding of TCAB1.
Freund A, Zhong FL, Venteicher AS, Meng Z, Veenstra TD, Frydman J, Artandi SE
Cell159(6)1389-403(2014 Dec)

Detection of mutations in TERT, the genes for telomerase reverse transcriptase, in Indian patients of aplastic anaemia: a pilot study.
Mehta S, Krishnamohan M, Gulati S, Sharmat N, Vashishtha P, Singh I
The Journal of the Association of Physicians of India62(10)13-7(2014 Oct)

GeneRIFs: Gene References Into Functions What's a GeneRIF?

Indian aplastic anemia patients did not have NOP10 mutations.
Title: Detection of mutations in TERT, the genes for telomerase reverse transcriptase, in Indian patients of aplastic anaemia: a pilot study.

Effects of dyskeratosis congenita mutations in NOP10 on assembly of H/ACA pre-RNPs
Title: Effects of dyskeratosis congenita mutations in dyskerin, NHP2 and NOP10 on assembly of H/ACA pre-RNPs.

NOP10 has a role in the telomerase complex and telomere maintenance, and in autosomal recessive dyskeratosis congenita
Title: Genetic heterogeneity in autosomal recessive dyskeratosis congenita with one subtype due to mutations in the telomerase-associated protein NOP10.

Observational study of gene-disease association. (HuGE Navigator)
Title: Mutations in TERT, the gene for telomerase reverse transcriptase, in aplastic anemia.

The following NOP10 gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the NOP10 cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1⁺/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.

***CloneID	Accession No.	Definition	**Vector	*Turnaround time	Price (USD)
OHu19474	NM_018648.4 Latest version!	Homo sapiens NOP10 ribonucleoprotein (NOP10), mRNA.	pcDNA3.1-C-(k)DYK or customized vector	in pcDNA3.1-C-(k)DYK	$49.50-$69.30 $99.00
View Old Accession Versions >>
OHu19474	NM_018648.3	Homo sapiens NOP10 ribonucleoprotein (NOP10), mRNA.	pcDNA3.1-C-(k)DYK or customized vector	in pcDNA3.1-C-(k)DYK	$49.50-$69.30 $99.00
Hide Old Accession Versions >>

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** You may select a custom vector to replace pcDNA3.1+/C-(K)DYK after clone is added to cart.

** GenScript guarantees 100% sequence accuracy of all synthetic DNA constructs we deliver, but we do not guarantee protein expression in your experimental system. Protein expression is influenced by many factors that may vary between experiments or laboratories. In addition, please pay attention to the signal peptide, propeptide and transit peptide in target ORF, which may affect the choice of vector (N/C terminal tag vector).

***One clone ID might be correlated to multiple accession numbers, which share the same CDS sequence.

Reference Sequences (Refseq)

NOP10 ( NM_018648.3 ) cDNA ORF clone, Homo sapiens(human) -> NP_061118.1 Homo sapiens NOP10 ribonucleoprotein (NOP10), mRNA.

Price & Availability↑

CloneID	OHu19474
Clone ID Related Accession (Same CDS sequence)	NM_018648.3 , NM_018648.4
Accession Version	NM_018648.3	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 195bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-06-07
Organism	Homo sapiens(human)
Product	H/ACA ribonucleoprotein complex subunit 3
Comment	Comment: REVIEWED REFSEQ: This record has been curated by NCBI staff. The reference sequence was derived from BQ218536.1 and BM554889.1. This sequence is a reference standard in the RefSeqGene project. On Oct 18, 2005 this sequence version replaced NM_018648.2. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: BU955288.1, AB043104.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA1968189, SAMEA1968540 [ECO:0000348] ##Evidence-Data-END## ##RefSeq-Attributes-START## RefSeq Select criteria :: based on single protein-coding transcript ##RefSeq-Attributes-END## COMPLETENESS: complete on the 3' end.

ATGTTTCTCC AGTATTACCT CAACGAGCAG GGAGATCGAG TCTATACGCT GAAGAAATTT 
GACCCGATGG GACAACAGAC CTGCTCAGCC CATCCTGCTC GGTTCTCCCC AGATGACAAA 
TACTCTCGAC ACCGAATCAC CATCAAGAAA CGCTTCAAGG TGCTCATGAC CCAGCAACCG 
CGCCCTGTCC TCTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_061118.1
CDS	89..283
Translation	MFLQYYLNEQGDRVYTLKKFDPMGQQTCSAHPARFSPDDKYSRHRITIKKRFKVLMTQQPRPVL

Target ORF information:

RefSeq Version	NM_018648.3
Organism	Homo sapiens(human)
Definition	Homo sapiens NOP10 ribonucleoprotein (NOP10), mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_018648.3

ORF Insert Sequence:

ATGTTTCTCC AGTATTACCT CAACGAGCAG GGAGATCGAG TCTATACGCT GAAGAAATTT 
GACCCGATGG GACAACAGAC CTGCTCAGCC CATCCTGCTC GGTTCTCCCC AGATGACAAA 
TACTCTCGAC ACCGAATCAC CATCAAGAAA CGCTTCAAGG TGCTCATGAC CCAGCAACCG 
CGCCCTGTCC TCTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

NOP10 ( NM_018648.4 ) cDNA ORF clone, Homo sapiens(human) -> NP_061118.1 Homo sapiens NOP10 ribonucleoprotein (NOP10), mRNA.

Price & Availability↑

CloneID	OHu19474
Clone ID Related Accession (Same CDS sequence)	NM_018648.3 , NM_018648.4
Accession Version	NM_018648.4 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 195bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-12-19
Organism	Homo sapiens(human)
Product	H/ACA ribonucleoprotein complex subunit 3
Comment	Comment: REVIEWED REFSEQ: This record has been curated by NCBI staff. The reference sequence was derived from BQ218536.1 and BM554889.1. On Dec 4, 2019 this sequence version replaced NM_018648.3. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: CF129182.1, BU541623.1 [ECO:0000332] ##Evidence-Data-END## ##RefSeq-Attributes-START## RefSeq Select criteria :: based on single protein-coding transcript ##RefSeq-Attributes-END## COMPLETENESS: complete on the 3' end.

ATGTTTCTCC AGTATTACCT CAACGAGCAG GGAGATCGAG TCTATACGCT GAAGAAATTT 
GACCCGATGG GACAACAGAC CTGCTCAGCC CATCCTGCTC GGTTCTCCCC AGATGACAAA 
TACTCTCGAC ACCGAATCAC CATCAAGAAA CGCTTCAAGG TGCTCATGAC CCAGCAACCG 
CGCCCTGTCC TCTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_061118.1
CDS	64..258
Translation	MFLQYYLNEQGDRVYTLKKFDPMGQQTCSAHPARFSPDDKYSRHRITIKKRFKVLMTQQPRPVL

Target ORF information:

RefSeq Version	NM_018648.4
Organism	Homo sapiens(human)
Definition	Homo sapiens NOP10 ribonucleoprotein (NOP10), mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_018648.4

ORF Insert Sequence:

ATGTTTCTCC AGTATTACCT CAACGAGCAG GGAGATCGAG TCTATACGCT GAAGAAATTT 
GACCCGATGG GACAACAGAC CTGCTCAGCC CATCCTGCTC GGTTCTCCCC AGATGACAAA 
TACTCTCGAC ACCGAATCAC CATCAAGAAA CGCTTCAAGG TGCTCATGAC CCAGCAACCG 
CGCCCTGTCC TCTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

PubMed

Widespread macromolecular interaction perturbations in human genetic disorders.
Cell161(3)647-660(2015 Apr)
Sahni N,Yi S,Taipale M,Fuxman Bass JI,Coulombe-Huntington J,Yang F,Peng J,Weile J,Karras GI,Wang Y,Kov?cs IA,Kamburov A,Krykbaeva I,Lam MH,Tucker G,Khurana V,Sharma A,Liu YY,Yachie N,Zhong Q,Shen Y,Palagi A,San-Miguel A,Fan C,Balcha D,Dricot A,Jordan DM,Walsh JM,Shah AA,Yang X,Stoyanova AK,Leighton A,Calderwood MA,Jacob Y,Cusick ME,Salehi-Ashtiani K,Whitesell LJ,Sunyaev S,Berger B,Barab?si AL,Charloteaux B,Hill DE,Hao T,Roth FP,Xia Y,Walhout AJM,Lindquist S,Vidal M

Proteostatic control of telomerase function through TRiC-mediated folding of TCAB1.
Cell159(6)1389-403(2014 Dec)
Freund A,Zhong FL,Venteicher AS,Meng Z,Veenstra TD,Frydman J,Artandi SE

Detection of mutations in TERT, the genes for telomerase reverse transcriptase, in Indian patients of aplastic anaemia: a pilot study.
The Journal of the Association of Physicians of India62(10)13-7(2014 Oct)
Mehta S,Krishnamohan M,Gulati S,Sharmat N,Vashishtha P,Singh I

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NOP10 cDNA ORF clone, Homo sapiens(human)

Gene

Clones

gRNAs

Related articles in PubMed

Target ORF information:

Target ORF information:

ORF Insert Sequence:

Target ORF information:

Target ORF information:

ORF Insert Sequence:

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