LRRC59 cDNA ORF clone, Homo sapiens(human)

Gene
Clones
gRNAs

Summary

Gene Symbol	LRRC59
Entrez Gene ID	55379
Full Name	leucine rich repeat containing 59
Synonyms	PRO1855,p34
General protein information	Preferred Names leucine rich repeat containing 59 Names leucine-rich repeat-containing protein 59 ribosome-binding protein p34
Gene Type	protein-coding
Organism	Homo sapiens(human)
Genome	Chromosome: 17 Map Location: 17q21.33
Disorder MIM:	614854

mRNA and Protein(s)

mRNA	Protein	Name
NM_018509.3	NP_060979.2	leucine-rich repeat-containing protein 59
NM_018509.4	NP_060979.2	leucine-rich repeat-containing protein 59

Pathways from BioSystems

Homologies

Bos taurus (cattle)	LRRC59	NP_001029750.1
Canis lupus familiaris (dog)	LRRC59	XP_548200.3
Caenorhabditis elegans (roundworm)	F56A8.3	NP_499730.1
Pan troglodytes (chimpanzee)	LRRC59	XP_511877.2
Homo sapiens (human)	LRRC59	NP_060979.2
Mus musculus (house mouse)	Lrrc59	NP_598568.1
Rattus norvegicus (Norway rat)	Lrrc59	NP_001008281.1
Gallus gallus (chicken)	LRRC59	NP_001012588.1
Danio rerio (zebrafish)	lrrc59	NP_998097.1
Xenopus tropicalis (tropical clawed frog)	lrrc59	NP_001001205.1

Gene Ontology
Bibliography

Related articles in PubMed

LRRC59 Regulates Trafficking of Nucleic Acid-Sensing TLRs from the Endoplasmic Reticulum via Association with UNC93B1.
Tatematsu M, Funami K, Ishii N, Seya T, Obuse C, Matsumoto M
Journal of immunology (Baltimore, Md. : 1950)195(10)4933-42(2015 Nov)

Leucine-rich repeat-containing protein 59 mediates nuclear import of cancerous inhibitor of PP2A in prostate cancer cells.
Pallai R, Bhaskar A, Barnett-Bernodat N, Gallo-Ebert C, Pusey M, Nickels JT Jr, Rice LM
Tumour biology : the journal of the International Society for Oncodevelopmental Biology and Medicine36(8)6383-90(2015 Aug)

E-cadherin interactome complexity and robustness resolved by quantitative proteomics.
Guo Z, Neilson LJ, Zhong H, Murray PS, Zanivan S, Zaidel-Bar R
Science signaling7(354)rs7(2014 Dec)

Insights into RNA biology from an atlas of mammalian mRNA-binding proteins.
Castello A, Fischer B, Eichelbaum K, Horos R, Beckmann BM, Strein C, Davey NE, Humphreys DT, Preiss T, Steinmetz LM, Krijgsveld J, Hentze MW
Cell149(6)1393-406(2012 Jun)

GeneRIFs: Gene References Into Functions What's a GeneRIF?

Endosomal localization of endogenous TLR3 was decreased by silencing of LRRC59, suggesting that LRRC59 promotes UNC93B1-mediated translocation of NA-sensing TLRs from the ER upon infection.
Title: LRRC59 Regulates Trafficking of Nucleic Acid-Sensing TLRs from the Endoplasmic Reticulum via Association with UNC93B1.

we provide a novel therapeutic mechanism for inhibiting CIP2A function in cancerous cells via targeting the CIP2A-LRRC59 interaction.
Title: Leucine-rich repeat-containing protein 59 mediates nuclear import of cancerous inhibitor of PP2A in prostate cancer cells.

LRRC59 facilitates transport of cytosolic FGF1 through nuclear pores by interaction with Kpns and movement of LRRC59 along the ER and NE membranes
Title: Nuclear import of exogenous FGF1 requires the ER-protein LRRC59 and the importins Kpn?1 and Kpn?1.

The following LRRC59 gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the LRRC59 cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1⁺/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.

***CloneID	Accession No.	Definition	**Vector	*Turnaround time	Price (USD)
OHu02814	NM_018509.4 Latest version!	Homo sapiens leucine rich repeat containing 59 (LRRC59), mRNA.	pcDNA3.1-C-(k)DYK or customized vector	in pcDNA3.1-C-(k)DYK	$154.50-$216.30 $309.00
View Old Accession Versions >>
OHu02814	NM_018509.3	Homo sapiens leucine rich repeat containing 59 (LRRC59), mRNA.	pcDNA3.1-C-(k)DYK or customized vector	in pcDNA3.1-C-(k)DYK	$154.50-$216.30 $309.00
Hide Old Accession Versions >>

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** GenScript guarantees 100% sequence accuracy of all synthetic DNA constructs we deliver, but we do not guarantee protein expression in your experimental system. Protein expression is influenced by many factors that may vary between experiments or laboratories. In addition, please pay attention to the signal peptide, propeptide and transit peptide in target ORF, which may affect the choice of vector (N/C terminal tag vector).

***One clone ID might be correlated to multiple accession numbers, which share the same CDS sequence.

Reference Sequences (Refseq)

LRRC59 ( NM_018509.3 ) cDNA ORF clone, Homo sapiens(human) -> NP_060979.2 Homo sapiens leucine rich repeat containing 59 (LRRC59), mRNA.

Price & Availability↑

CloneID	OHu02814
Clone ID Related Accession (Same CDS sequence)	NM_018509.3 , NM_018509.4
Accession Version	NM_018509.3	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 924bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2017-10-01
Organism	Homo sapiens(human)
Product	leucine-rich repeat-containing protein 59
Comment	Comment: VALIDATED REFSEQ: This record has undergone validation or preliminary review. The reference sequence was derived from DA782636.1, BC017168.1, AF119857.1 and BM664133.1. On May 21, 2010 this sequence version replaced NM_018509.2. ##Evidence-Data-START## Transcript exon combination :: AK025328.1, SRR1660809.204451.1 [ECO:0000332] RNAseq introns :: mixed/partial sample support SAMEA1965299, SAMEA1966682 [ECO:0000350] ##Evidence-Data-END## COMPLETENESS: complete on the 3' end.

ATGACCAAGG CCGGTAGCAA GGGCGGGAAC CTCCGCGACA AGCTGGACGG CAACGAACTG 
GACCTGAGCC TCAGCGACCT GAATGAGGTC CCGGTGAAGG AGCTGGCTGC CCTTCCAAAG 
GCCACCATCC TGGATCTGTC TTGTAATAAA CTGACTACTC TACCGTCGGA TTTCTGTGGC 
CTCACACACC TGGTGAAGCT AGACCTGAGT AAGAACAAGC TGCAGCAGCT GCCAGCAGAC 
TTTGGCCGTC TGGTCAACCT CCAGCACCTG GATCTCCTCA ACAACAAGCT GGTCACCTTG 
CCTGTCAGCT TTGCTCAGCT CAAGAACCTG AAGTGGTTGG ACCTGAAGGA TAACCCCCTG 
GATCCTGTCC TGGCCAAGGT GGCAGGTGAC TGCTTGGATG AGAAGCAGTG TAAGCAGTGT 
GCAAACAAGG TGTTACAGCA CATGAAGGCC GTGCAGGCAG ATCAGGAGCG GGAGAGGCAG 
CGGCGGCTGG AAGTAGAACG TGAGGCAGAG AAGAAGCGTG AGGCTAAGCA GCGAGCTAAG 
GAAGCTCAGG AGCGGGAACT GCGGAAGCGG GAGAAGGCGG AAGAGAAGGA GCGCCGGAGA 
AAGGAGTATG ATGCCCTCAA AGCAGCCAAG CGGGAGCAGG AGAAGAAACC TAAGAAGGAA 
GCAAATCAGG CCCCGAAATC TAAGTCTGGC TCCCGTCCCC GCAAGCCACC ACCCCGGAAG 
CACACTCGTT CCTGGGCTGT GCTGAAGCTG CTGCTGCTGC TGCTGCTATT TGGTGTGGCG 
GGAGGGCTGG TTGCTTGTCG GGTGACAGAG CTGCAGCAGC AGCCCCTCTG CACCAGCGTG 
AACACCATCT ATGACAATGC GGTCCAGGGT CTACGCCGCC ATGAGATCCT CCAGTGGGTC 
CTCCAGACCG ACTCTCAGCA GTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_060979.2
CDS	237..1160
Translation	MTKAGSKGGNLRDKLDGNELDLSLSDLNEVPVKELAALPKATILDLSCNKLTTLPSDFCGLTHLVKLDLSKNKLQQLPADFGRLVNLQHLDLLNNKLVTLPVSFAQLKNLKWLDLKDNPLDPVLAKVAGDCLDEKQCKQCANKVLQHMKAVQADQERERQRRLEVEREAEKKREAKQRAKEAQERELRKREKAEEKERRRKEYDALKAAKREQEKKPKKEANQAPKSKSGSRPRKPPPRKHTRSWAVLKLLLLLLLFGVAGGLVACRVTELQQQPLCTSVNTIYDNAVQGLRRHEILQWVLQTDSQQ

Target ORF information:

RefSeq Version	NM_018509.3
Organism	Homo sapiens(human)
Definition	Homo sapiens leucine rich repeat containing 59 (LRRC59), mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_018509.3

ORF Insert Sequence:

ATGACCAAGG CCGGTAGCAA GGGCGGGAAC CTCCGCGACA AGCTGGACGG CAACGAACTG 
GACCTGAGCC TCAGCGACCT GAATGAGGTC CCGGTGAAGG AGCTGGCTGC CCTTCCAAAG 
GCCACCATCC TGGATCTGTC TTGTAATAAA CTGACTACTC TACCGTCGGA TTTCTGTGGC 
CTCACACACC TGGTGAAGCT AGACCTGAGT AAGAACAAGC TGCAGCAGCT GCCAGCAGAC 
TTTGGCCGTC TGGTCAACCT CCAGCACCTG GATCTCCTCA ACAACAAGCT GGTCACCTTG 
CCTGTCAGCT TTGCTCAGCT CAAGAACCTG AAGTGGTTGG ACCTGAAGGA TAACCCCCTG 
GATCCTGTCC TGGCCAAGGT GGCAGGTGAC TGCTTGGATG AGAAGCAGTG TAAGCAGTGT 
GCAAACAAGG TGTTACAGCA CATGAAGGCC GTGCAGGCAG ATCAGGAGCG GGAGAGGCAG 
CGGCGGCTGG AAGTAGAACG TGAGGCAGAG AAGAAGCGTG AGGCTAAGCA GCGAGCTAAG 
GAAGCTCAGG AGCGGGAACT GCGGAAGCGG GAGAAGGCGG AAGAGAAGGA GCGCCGGAGA 
AAGGAGTATG ATGCCCTCAA AGCAGCCAAG CGGGAGCAGG AGAAGAAACC TAAGAAGGAA 
GCAAATCAGG CCCCGAAATC TAAGTCTGGC TCCCGTCCCC GCAAGCCACC ACCCCGGAAG 
CACACTCGTT CCTGGGCTGT GCTGAAGCTG CTGCTGCTGC TGCTGCTATT TGGTGTGGCG 
GGAGGGCTGG TTGCTTGTCG GGTGACAGAG CTGCAGCAGC AGCCCCTCTG CACCAGCGTG 
AACACCATCT ATGACAATGC GGTCCAGGGT CTACGCCGCC ATGAGATCCT CCAGTGGGTC 
CTCCAGACCG ACTCTCAGCA GTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

LRRC59 ( NM_018509.4 ) cDNA ORF clone, Homo sapiens(human) -> NP_060979.2 Homo sapiens leucine rich repeat containing 59 (LRRC59), mRNA.

Price & Availability↑

CloneID	OHu02814
Clone ID Related Accession (Same CDS sequence)	NM_018509.3 , NM_018509.4
Accession Version	NM_018509.4 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 924bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-05-06
Organism	Homo sapiens(human)
Product	leucine-rich repeat-containing protein 59
Comment	Comment: VALIDATED REFSEQ: This record has undergone validation or preliminary review. The reference sequence was derived from DA782636.1, BC017168.1 and AF119857.1. On Nov 23, 2018 this sequence version replaced NM_018509.3. ##Evidence-Data-START## Transcript exon combination :: AK025328.1, SRR3476690.623316.1 [ECO:0000332] RNAseq introns :: mixed/partial sample support SAMEA1965299, SAMEA1966682 [ECO:0000350] ##Evidence-Data-END## ##RefSeq-Attributes-START## MANE Ensembl match :: ENST00000225972.8/ ENSP00000225972.7 RefSeq Select criteria :: based on single protein-coding transcript ##RefSeq-Attributes-END## COMPLETENESS: full length.

ATGACCAAGG CCGGTAGCAA GGGCGGGAAC CTCCGCGACA AGCTGGACGG CAACGAACTG 
GACCTGAGCC TCAGCGACCT GAATGAGGTC CCGGTGAAGG AGCTGGCTGC CCTTCCAAAG 
GCCACCATCC TGGATCTGTC TTGTAATAAA CTGACTACTC TACCGTCGGA TTTCTGTGGC 
CTCACACACC TGGTGAAGCT AGACCTGAGT AAGAACAAGC TGCAGCAGCT GCCAGCAGAC 
TTTGGCCGTC TGGTCAACCT CCAGCACCTG GATCTCCTCA ACAACAAGCT GGTCACCTTG 
CCTGTCAGCT TTGCTCAGCT CAAGAACCTG AAGTGGTTGG ACCTGAAGGA TAACCCCCTG 
GATCCTGTCC TGGCCAAGGT GGCAGGTGAC TGCTTGGATG AGAAGCAGTG TAAGCAGTGT 
GCAAACAAGG TGTTACAGCA CATGAAGGCC GTGCAGGCAG ATCAGGAGCG GGAGAGGCAG 
CGGCGGCTGG AAGTAGAACG TGAGGCAGAG AAGAAGCGTG AGGCTAAGCA GCGAGCTAAG 
GAAGCTCAGG AGCGGGAACT GCGGAAGCGG GAGAAGGCGG AAGAGAAGGA GCGCCGGAGA 
AAGGAGTATG ATGCCCTCAA AGCAGCCAAG CGGGAGCAGG AGAAGAAACC TAAGAAGGAA 
GCAAATCAGG CCCCGAAATC TAAGTCTGGC TCCCGTCCCC GCAAGCCACC ACCCCGGAAG 
CACACTCGTT CCTGGGCTGT GCTGAAGCTG CTGCTGCTGC TGCTGCTATT TGGTGTGGCG 
GGAGGGCTGG TTGCTTGTCG GGTGACAGAG CTGCAGCAGC AGCCCCTCTG CACCAGCGTG 
AACACCATCT ATGACAATGC GGTCCAGGGT CTACGCCGCC ATGAGATCCT CCAGTGGGTC 
CTCCAGACCG ACTCTCAGCA GTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_060979.2
CDS	207..1130
Translation	MTKAGSKGGNLRDKLDGNELDLSLSDLNEVPVKELAALPKATILDLSCNKLTTLPSDFCGLTHLVKLDLSKNKLQQLPADFGRLVNLQHLDLLNNKLVTLPVSFAQLKNLKWLDLKDNPLDPVLAKVAGDCLDEKQCKQCANKVLQHMKAVQADQERERQRRLEVEREAEKKREAKQRAKEAQERELRKREKAEEKERRRKEYDALKAAKREQEKKPKKEANQAPKSKSGSRPRKPPPRKHTRSWAVLKLLLLLLLFGVAGGLVACRVTELQQQPLCTSVNTIYDNAVQGLRRHEILQWVLQTDSQQ

Target ORF information:

RefSeq Version	NM_018509.4
Organism	Homo sapiens(human)
Definition	Homo sapiens leucine rich repeat containing 59 (LRRC59), mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_018509.4

ORF Insert Sequence:

ATGACCAAGG CCGGTAGCAA GGGCGGGAAC CTCCGCGACA AGCTGGACGG CAACGAACTG 
GACCTGAGCC TCAGCGACCT GAATGAGGTC CCGGTGAAGG AGCTGGCTGC CCTTCCAAAG 
GCCACCATCC TGGATCTGTC TTGTAATAAA CTGACTACTC TACCGTCGGA TTTCTGTGGC 
CTCACACACC TGGTGAAGCT AGACCTGAGT AAGAACAAGC TGCAGCAGCT GCCAGCAGAC 
TTTGGCCGTC TGGTCAACCT CCAGCACCTG GATCTCCTCA ACAACAAGCT GGTCACCTTG 
CCTGTCAGCT TTGCTCAGCT CAAGAACCTG AAGTGGTTGG ACCTGAAGGA TAACCCCCTG 
GATCCTGTCC TGGCCAAGGT GGCAGGTGAC TGCTTGGATG AGAAGCAGTG TAAGCAGTGT 
GCAAACAAGG TGTTACAGCA CATGAAGGCC GTGCAGGCAG ATCAGGAGCG GGAGAGGCAG 
CGGCGGCTGG AAGTAGAACG TGAGGCAGAG AAGAAGCGTG AGGCTAAGCA GCGAGCTAAG 
GAAGCTCAGG AGCGGGAACT GCGGAAGCGG GAGAAGGCGG AAGAGAAGGA GCGCCGGAGA 
AAGGAGTATG ATGCCCTCAA AGCAGCCAAG CGGGAGCAGG AGAAGAAACC TAAGAAGGAA 
GCAAATCAGG CCCCGAAATC TAAGTCTGGC TCCCGTCCCC GCAAGCCACC ACCCCGGAAG 
CACACTCGTT CCTGGGCTGT GCTGAAGCTG CTGCTGCTGC TGCTGCTATT TGGTGTGGCG 
GGAGGGCTGG TTGCTTGTCG GGTGACAGAG CTGCAGCAGC AGCCCCTCTG CACCAGCGTG 
AACACCATCT ATGACAATGC GGTCCAGGGT CTACGCCGCC ATGAGATCCT CCAGTGGGTC 
CTCCAGACCG ACTCTCAGCA GTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

PubMed

LRRC59 Regulates Trafficking of Nucleic Acid-Sensing TLRs from the Endoplasmic Reticulum via Association with UNC93B1.
Journal of immunology (Baltimore, Md. : 1950)195(10)4933-42(2015 Nov)
Tatematsu M,Funami K,Ishii N,Seya T,Obuse C,Matsumoto M

Leucine-rich repeat-containing protein 59 mediates nuclear import of cancerous inhibitor of PP2A in prostate cancer cells.
Tumour biology : the journal of the International Society for Oncodevelopmental Biology and Medicine36(8)6383-90(2015 Aug)
Pallai R,Bhaskar A,Barnett-Bernodat N,Gallo-Ebert C,Pusey M,Nickels JT Jr,Rice LM

E-cadherin interactome complexity and robustness resolved by quantitative proteomics.
Science signaling7(354)rs7(2014 Dec)
Guo Z,Neilson LJ,Zhong H,Murray PS,Zanivan S,Zaidel-Bar R

Insights into RNA biology from an atlas of mammalian mRNA-binding proteins.
Cell149(6)1393-406(2012 Jun)
Castello A,Fischer B,Eichelbaum K,Horos R,Beckmann BM,Strein C,Davey NE,Humphreys DT,Preiss T,Steinmetz LM,Krijgsveld J,Hentze MW

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LRRC59 cDNA ORF clone, Homo sapiens(human)

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Related articles in PubMed

Target ORF information:

Target ORF information:

ORF Insert Sequence:

Target ORF information:

Target ORF information:

ORF Insert Sequence:

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