PI4K2A cDNA ORF clone, Homo sapiens(human)

PI-273, a Substrate-Competitive, Specific Small-Molecule Inhibitor of PI4KII?, Inhibits the Growth of Breast Cancer Cells.
Li J, Gao Z, Zhao D, Zhang L, Qiao X, Zhao Y, Ding H, Zhang P, Lu J, Liu J, Jiang H, Luo C, Chen C
Cancer research77(22)6253-6266(2017 Nov)

Phosphatidylinositol 4-kinase II? negatively regulates invadopodia formation and suppresses an invasive cellular phenotype.
Alli-Balogun GO, Gewinner CA, Jacobs R, Kriston-Vizi J, Waugh MG, Minogue S
Molecular biology of the cell27(25)4033-4042(2016 Dec)

Type II PI4-kinases control Weibel-Palade body biogenesis and von Willebrand factor structure in human endothelial cells.
Lopes da Silva M, O'Connor MN, Kriston-Vizi J, White IJ, Al-Shawi R, Simons JP, M?ssinger J, Haucke V, Cutler DF
Journal of cell science129(10)2096-105(2016 05)

PI-273 is the first substrate-competitive, subtype-specific inhibitor of PI4KIIalpha, the use of which will facilitate evaluations of PI4KIIalpha as a cancer therapeutic target.
Title: PI-273, a Substrate-Competitive, Specific Small-Molecule Inhibitor of PI4KII?, Inhibits the Growth of Breast Cancer Cells.

Mining oncogenomic databases revealed that loss of the PI4K2B allele and underexpression of PI4KIIbeta mRNA are associated with human cancers. This finding supports the cell data and suggests that PI4KIIbeta may be a clinically significant suppressor of invasion.
Title: Phosphatidylinositol 4-kinase II? negatively regulates invadopodia formation and suppresses an invasive cellular phenotype.

RNA interference of the type II phosphatidylinositol 4-kinases PI4KIIa and PI4KIIa in primary human endothelial cells leads to formation of an increased proportion of short WPB with perturbed packing of VWF, as exemplified by increased exposure of antibody-binding sites.
Title: Type II PI4-kinases control Weibel-Palade body biogenesis and von Willebrand factor structure in human endothelial cells.

PtdIns4KIIalpha regulates receptor sorting at early endosomes through a PtdIns(4)P-dependent pathway and contributes substrate for the synthesis of endosomal PtdIns(4,5)P2.
Title: PtdIns4KII? generates endosomal PtdIns(4)P and is required for receptor sorting at early endosomes.

Here two crystal structures are presented: the structure of human PIK42A and the structure of PIK42B containing a nucleoside analogue.
Title: The high-resolution crystal structure of phosphatidylinositol 4-kinase II? and the crystal structure of phosphatidylinositol 4-kinase II? containing a nucleoside analogue provide a structural basis for isoform-specific inhibitor design.