GIMAP5 cDNA ORF clone, Homo sapiens(human)

Gene
Clones
gRNAs

Summary

Gene Symbol	GIMAP5
Entrez Gene ID	55340
Full Name	GTPase, IMAP family member 5
Synonyms	HIMAP3,IAN-5,IAN4,IAN4L1,IAN5,IMAP3,IROD
General protein information	Preferred Names GTPase, IMAP family member 5 Names GTPase IMAP family member 5 immune associated nucleotide 4 like 1 immune-associated nucleotide-binding protein 5 immunity associated protein 3 immunity-associated nucleotide 5 protein inhibitor of radiation- and OA-induced apoptosis, Irod/Ian5
Gene Type	protein-coding
Organism	Homo sapiens(human)
Genome	Chromosome: 7 Map Location: 7q36.1
Summary	This gene encodes a protein belonging to the GTP-binding superfamily and to the immuno-associated nucleotide (IAN) subfamily of nucleotide-binding proteins. In humans, the IAN subfamily genes are located in a cluster at 7q36.1. This gene encodes an antiapoptotic protein that functions in T-cell survival. Polymorphisms in this gene are associated with systemic lupus erythematosus. Read-through transcription exists between this gene and the neighboring upstream GIMAP1 (GTPase, IMAP family member 1) gene. [provided by RefSeq, Dec 2010].
Disorder MIM:	608086

mRNA and Protein(s)

mRNA	Protein	Name
NM_018384.4	NP_060854.2	GTPase IMAP family member 5

Pathways from BioSystems
Gene Ontology
Bibliography

Related articles in PubMed

Dysregulation of GTPase IMAP family members in hepatocellular cancer.
Huang Z, Zhang W, Gao C, Ji B, Chi X, Zheng W, Wang HL
Molecular medicine reports14(5)4119-4123(2016 Nov)

Central role of gimap5 in maintaining peripheral tolerance and T cell homeostasis in the gut.
Endale M, Aksoylar HI, Hoebe K
Mediators of inflammation2015436017(2015)

Notch protection against apoptosis in T-ALL cells mediated by GIMAP5.
Chadwick N, Zeef L, Portillo V, Boros J, Hoyle S, van Doesburg JC, Buckle AM
Blood cells, molecules & diseases45(3)201-9(2010 Oct)

hIan5: the human ortholog to the rat Ian4/Iddm1/lyp is a new member of the Ian family that is overexpressed in B-cell lymphoid malignancies.
Zenz T, Roessner A, Thomas A, Fr?hling S, D?hner H, Calabretta B, Dah?ron L
Genes and immunity5(2)109-16(2004 Mar)

GeneRIFs: Gene References Into Functions What's a GeneRIF?

These data,demonstrating the downregulation of the mRNA and protein expression levels of GIMAP5 and GIMAP6 in the tumor tissues and blood of patients with HCC, suggested the involvement of GIMAP5 and GIMAP6 in the pathogenesis of HCC, and indicate their possible use as diagnostic markers for HCC.
Title: Dysregulation of GTPase IMAP family members in hepatocellular cancer.

gimap5 has a role in maintaining peripheral tolerance and T cell homeostasis in the gut [review]
Title: Central role of gimap5 in maintaining peripheral tolerance and T cell homeostasis in the gut.

Data indicate that overexpression of GTPase of the immune-associated nucleotide-binding protein 5 (GIMAP5) in HEK (human embryonic kidney)-293 cells resulted in increased Ca2+ accumulation within the mitochondria.
Title: GTPase of the immune-associated nucleotide-binding protein 5 (GIMAP5) regulates calcium influx in T-lymphocytes by promoting mitochondrial calcium accumulation.

Notch signalling protects T-ALL cells from apoptosis by upregulating the expression of GIMAP5.
Title: Notch protection against apoptosis in T-ALL cells mediated by GIMAP5.

Observational study of gene-disease association. (HuGE Navigator)
Title: New genetic associations detected in a host response study to hepatitis B vaccine.

The following GIMAP5 gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the GIMAP5 cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1⁺/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.

***CloneID	Accession No.	Definition	**Vector	*Turnaround time	Price (USD)	Select
OHu15428	NM_018384.4 Latest version!	Homo sapiens GTPase, IMAP family member 5 (GIMAP5), mRNA.	pcDNA3.1-C-(k)DYK or customized vector	in pcDNA3.1-C-(k)DYK	$154.50-$216.30 $309.00

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** GenScript guarantees 100% sequence accuracy of all synthetic DNA constructs we deliver, but we do not guarantee protein expression in your experimental system. Protein expression is influenced by many factors that may vary between experiments or laboratories. In addition, please pay attention to the signal peptide, propeptide and transit peptide in target ORF, which may affect the choice of vector (N/C terminal tag vector).

***One clone ID might be correlated to multiple accession numbers, which share the same CDS sequence.

Reference Sequences (Refseq)

GIMAP5 ( NM_018384.4 ) cDNA ORF clone, Homo sapiens(human) -> NP_060854.2 Homo sapiens GTPase, IMAP family member 5 (GIMAP5), mRNA.

Price & Availability↑

CloneID	OHu15428
Clone ID Related Accession (Same CDS sequence)	NM_018384.4
Accession Version	NM_018384.4 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 924bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-12-27
Organism	Homo sapiens(human)
Product	GTPase IMAP family member 5
Comment	Comment: REVIEWED REFSEQ: This record has been curated by NCBI staff. The reference sequence was derived from AV762634.1, AC006479.2 and CA431916.1. On Dec 9, 2010 this sequence version replaced NM_018384.3. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: AV762634.1, SRR1803616.172570.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA1965299, SAMEA1966682 [ECO:0000348] ##Evidence-Data-END## ##RefSeq-Attributes-START## RefSeq Select criteria :: based on single protein-coding transcript ##RefSeq-Attributes-END## COMPLETENESS: complete on the 3' end.

ATGGGAGGAT TCCAGAGGGG CAAATATGGA ACTATGGCTG AAGGTAGATC AGAAGATAAC 
TTGTCTGCAA CACCACCGGC ATTGAGGATT ATCCTAGTGG GCAAAACAGG CTGCGGGAAA 
AGTGCCACAG GGAACAGCAT CCTTGGCCAG CCCGTGTTTG AGTCCAAGCT GAGGGCCCAG 
TCAGTGACCA GGACGTGCCA GGTGAAAACA GGAACATGGA ACGGGAGGAA AGTCCTGGTG 
GTTGACACGC CCTCCATCTT TGAGTCACAG GCCGATACCC AAGAGCTGTA CAAGAACATC 
GGGGACTGCT ACCTGCTCTC TGCCCCGGGG CCCCACGTCC TGCTTCTGGT GATCCAGCTG 
GGGCGTTTCA CTGCTCAGGA CACAGTGGCC ATCAGGAAGG TGAAAGAGGT CTTTGGGACA 
GGGGCCATGA GACATGTGGT CATCCTCTTC ACCCACAAAG AGGACTTAGG GGGCCAGGCC 
CTGGATGACT ATGTAGCAAA CACGGACAAC TGCAGCCTGA AAGACCTGGT GCGGGAGTGT 
GAGAGAAGGT ACTGTGCCTT CAACAACTGG GGCTCTGTGG AGGAGCAGAG GCAGCAGCAG 
GCAGAGCTCC TGGCTGTGAT TGAGAGGCTG GGGAGGGAGC GAGAGGGCTC CTTCCACAGC 
AATGACCTCT TCTTGGATGC CCAGCTGCTC CAAAGAACTG GAGCTGGGGC CTGCCAGGAA 
GACTACAGGC AGTACCAGGC CAAAGTGGAA TGGCAGGTGG AGAAGCACAA GCAAGAGCTG 
AGGGAGAACG AGAGTAACTG GGCATACAAG GCGCTCCTCA GAGTCAAACA CTTGATGCTT 
TTGCATTATG AGATTTTTGT TTTTCTATTG TTGTGCAGCA TACTTTTTTT CATTATTTTT 
CTGTTCATCT TTCATTACAT TTAA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_060854.2
CDS	368..1291
Translation	MGGFQRGKYGTMAEGRSEDNLSATPPALRIILVGKTGCGKSATGNSILGQPVFESKLRAQSVTRTCQVKTGTWNGRKVLVVDTPSIFESQADTQELYKNIGDCYLLSAPGPHVLLLVIQLGRFTAQDTVAIRKVKEVFGTGAMRHVVILFTHKEDLGGQALDDYVANTDNCSLKDLVRECERRYCAFNNWGSVEEQRQQQAELLAVIERLGREREGSFHSNDLFLDAQLLQRTGAGACQEDYRQYQAKVEWQVEKHKQELRENESNWAYKALLRVKHLMLLHYEIFVFLLLCSILFFIIFLFIFHYI

Target ORF information:

RefSeq Version	NM_018384.4
Organism	Homo sapiens(human)
Definition	Homo sapiens GTPase, IMAP family member 5 (GIMAP5), mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_018384.4

ORF Insert Sequence:

ATGGGAGGAT TCCAGAGGGG CAAATATGGA ACTATGGCTG AAGGTAGATC AGAAGATAAC 
TTGTCTGCAA CACCACCGGC ATTGAGGATT ATCCTAGTGG GCAAAACAGG CTGCGGGAAA 
AGTGCCACAG GGAACAGCAT CCTTGGCCAG CCCGTGTTTG AGTCCAAGCT GAGGGCCCAG 
TCAGTGACCA GGACGTGCCA GGTGAAAACA GGAACATGGA ACGGGAGGAA AGTCCTGGTG 
GTTGACACGC CCTCCATCTT TGAGTCACAG GCCGATACCC AAGAGCTGTA CAAGAACATC 
GGGGACTGCT ACCTGCTCTC TGCCCCGGGG CCCCACGTCC TGCTTCTGGT GATCCAGCTG 
GGGCGTTTCA CTGCTCAGGA CACAGTGGCC ATCAGGAAGG TGAAAGAGGT CTTTGGGACA 
GGGGCCATGA GACATGTGGT CATCCTCTTC ACCCACAAAG AGGACTTAGG GGGCCAGGCC 
CTGGATGACT ATGTAGCAAA CACGGACAAC TGCAGCCTGA AAGACCTGGT GCGGGAGTGT 
GAGAGAAGGT ACTGTGCCTT CAACAACTGG GGCTCTGTGG AGGAGCAGAG GCAGCAGCAG 
GCAGAGCTCC TGGCTGTGAT TGAGAGGCTG GGGAGGGAGC GAGAGGGCTC CTTCCACAGC 
AATGACCTCT TCTTGGATGC CCAGCTGCTC CAAAGAACTG GAGCTGGGGC CTGCCAGGAA 
GACTACAGGC AGTACCAGGC CAAAGTGGAA TGGCAGGTGG AGAAGCACAA GCAAGAGCTG 
AGGGAGAACG AGAGTAACTG GGCATACAAG GCGCTCCTCA GAGTCAAACA CTTGATGCTT 
TTGCATTATG AGATTTTTGT TTTTCTATTG TTGTGCAGCA TACTTTTTTT CATTATTTTT 
CTGTTCATCT TTCATTACAT TTAA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

PubMed

Dysregulation of GTPase IMAP family members in hepatocellular cancer.
Molecular medicine reports14(5)4119-4123(2016 Nov)
Huang Z,Zhang W,Gao C,Ji B,Chi X,Zheng W,Wang HL

Central role of gimap5 in maintaining peripheral tolerance and T cell homeostasis in the gut.
Mediators of inflammation2015436017(2015)
Endale M,Aksoylar HI,Hoebe K

Notch protection against apoptosis in T-ALL cells mediated by GIMAP5.
Blood cells, molecules & diseases45(3)201-9(2010 Oct)
Chadwick N,Zeef L,Portillo V,Boros J,Hoyle S,van Doesburg JC,Buckle AM

hIan5: the human ortholog to the rat Ian4/Iddm1/lyp is a new member of the Ian family that is overexpressed in B-cell lymphoid malignancies.
Genes and immunity5(2)109-16(2004 Mar)
Zenz T,Roessner A,Thomas A,Fr?hling S,D?hner H,Calabretta B,Dah?ron L

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GIMAP5 cDNA ORF clone, Homo sapiens(human)

Gene

Clones

gRNAs

Related articles in PubMed

Target ORF information:

Target ORF information:

ORF Insert Sequence:

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