PPP1R3C cDNA ORF clone, Homo sapiens(human)

Gene
Clones
gRNAs

Summary

Gene Symbol	PPP1R3C
Entrez Gene ID	5507
Full Name	protein phosphatase 1 regulatory subunit 3C
Synonyms	PPP1R5,PTG
General protein information	Preferred Names protein phosphatase 1 regulatory subunit 3C Names protein phosphatase 1 regulatory subunit 3C PP1 subunit R5 Phosphatase 1, regulatory inhibitor subunit 5 protein phosphatase 1 regulatory subunit 5 protein phosphatase 1, regulatory (inhibitor) subunit 3C protein targeting to glycogen
Gene Type	protein-coding
Organism	Homo sapiens(human)
Genome	Chromosome: 10 Map Location: 10q23.32
Summary	This gene encodes a carbohydrate binding protein that is a subunit of the protein phosphatase 1 (PP1) complex. PP1 catalyzes reversible protein phosphorylation, which is important in a wide range of cellular activities. The encoded protein affects glycogen biosynthesis by activating glycogen synthase and limiting glycogen breakdown by reducing glycogen phosphorylase activity. DNA hypermethylation of this gene has been found in colorectal cancer patients. The encoded protein also interacts with the laforin protein, which is a protein tyrosine phosphatase implicated in Lafora disease. [provided by RefSeq, Sep 2016].
Disorder MIM:	602999

mRNA and Protein(s)

mRNA	Protein	Name
NM_005398.6	NP_005389.1	protein phosphatase 1 regulatory subunit 3C
NM_005398.5	NP_005389.1	protein phosphatase 1 regulatory subunit 3C
NM_005398.7	NP_005389.1	protein phosphatase 1 regulatory subunit 3C

Pathways from BioSystems

Homologies

Canis lupus familiaris (dog)	PPP1R3C	XP_534961.3
Rattus norvegicus (Norway rat)	Ppp1r3c	NP_001012072.1
Pan troglodytes (chimpanzee)	PPP1R3C	XP_507911.2
Gallus gallus (chicken)	PPP1R3C	XP_423102.2
	PPP1R3C	XP_001088532.1
Bos taurus (cattle)	PPP1R3C	NP_001069632.1
Mus musculus (house mouse)	Ppp1r3c	NP_058550.1
Homo sapiens (human)	PPP1R3C	NP_005389.1
Rattus norvegicus (Norway rat)	LOC100910671	XP_006231374.1
Danio rerio (zebrafish)	ppp1r3cb	NP_957128.1
Xenopus tropicalis (tropical clawed frog)	ppp1r3c.1	NP_001106579.1

Gene Ontology
Bibliography

Related articles in PubMed

Architecture of the human interactome defines protein communities and disease networks.
Huttlin EL, Bruckner RJ, Paulo JA, Cannon JR, Ting L, Baltier K, Colby G, Gebreab F, Gygi MP, Parzen H, Szpyt J, Tam S, Zarraga G, Pontano-Vaites L, Swarup S, White AE, Schweppe DK, Rad R, Erickson BK, Obar RA, Guruharsha KG, Li K, Artavanis-Tsakonas S, Gygi SP, Harper JW
Nature545(7655)505-509(2017 05)

Systematic Analysis of Human Protein Phosphatase Interactions and Dynamics.
Yadav L, Tamene F, G??s H, van Drogen A, Katainen R, Aebersold R, Gstaiger M, Varjosalo M
Cell systems4(4)430-444.e5(2017 Apr)

Role of glycogen phosphorylase in liver glycogen metabolism.
Agius L
Molecular aspects of medicine4634-45(2015 Dec)

The effect of high glucose levels on the hypermethylation of protein phosphatase 1 regulatory subunit 3C (PPP1R3C) gene in colorectal cancer.
Lee SK, Moon JW, Lee YW, Lee JO, Kim SJ, Kim N, Kim J, Kim HS, Park SH
Journal of genetics94(1)75-85(2015 Mar)

Aberrant promoter methylation of PPP1R3C and EFHD1 in plasma of colorectal cancer patients.
Takane K, Midorikawa Y, Yagi K, Sakai A, Aburatani H, Takayama T, Kaneda A
Cancer medicine3(5)1235-45(2014 Oct)

GeneRIFs: Gene References Into Functions What's a GeneRIF?

PPP1R3C, a novel hypermethylated gene in colorectal cancer, may play a critical role in cancer cell growth in association with glucose levels.
Title: The effect of high glucose levels on the hypermethylation of protein phosphatase 1 regulatory subunit 3C (PPP1R3C) gene in colorectal cancer.

detection of methylation of PPP1R3C alone or in combination with EFHD1 in plasma DNA showed high sensitivity and specificity in CRC detection, and may be useful detection method for CRC, especially for early-stage CRCs.
Title: Aberrant promoter methylation of PPP1R3C and EFHD1 in plasma of colorectal cancer patients.

Findings suggest that variations in PTG may condition the course of Lafora disease and establish PTG as a potential target for pharmacogenetic and therapeutic approaches.
Title: A PTG variant contributes to a milder phenotype in Lafora disease.

Results demonstrated that HIF1 promotes glycogen accumulation through regulating PPP1R3C expression under hypoxia, which revealed a novel metabolic adaptation of cells to hypoxia.
Title: Hypoxia-inducible factor 1-mediated regulation of PPP1R3C promotes glycogen accumulation in human MCF-7 cells under hypoxia.

phosphorylation of R5/PTG at Ser-8 by AMPK accelerates its laforin/malin-dependent ubiquitination and subsequent proteasomal degradation, which results in a decrease of its glycogenic activity.
Title: AMP-activated protein kinase phosphorylates R5/PTG, the glycogen targeting subunit of the R5/PTG-protein phosphatase 1 holoenzyme, and accelerates its down-regulation by the laforin-malin complex.

The following PPP1R3C gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the PPP1R3C cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1⁺/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.

***CloneID	Accession No.	Definition	**Vector	*Turnaround time	Price (USD)
OHu55887	NM_005398.7 Latest version!	Homo sapiens protein phosphatase 1 regulatory subunit 3C (PPP1R3C), mRNA.	pcDNA3.1-C-(k)DYK or customized vector	in pcDNA3.1-C-(k)DYK	$154.50-$216.30 $309.00
View Old Accession Versions >>
OHu55887	NM_005398.5	Homo sapiens protein phosphatase 1, regulatory subunit 3C (PPP1R3C), mRNA.	pcDNA3.1-C-(k)DYK or customized vector	in pcDNA3.1-C-(k)DYK	$154.50-$216.30 $309.00
OHu55887	NM_005398.6	Homo sapiens protein phosphatase 1 regulatory subunit 3C (PPP1R3C), mRNA.	pcDNA3.1-C-(k)DYK or customized vector	in pcDNA3.1-C-(k)DYK	$154.50-$216.30 $309.00
Hide Old Accession Versions >>

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** GenScript guarantees 100% sequence accuracy of all synthetic DNA constructs we deliver, but we do not guarantee protein expression in your experimental system. Protein expression is influenced by many factors that may vary between experiments or laboratories. In addition, please pay attention to the signal peptide, propeptide and transit peptide in target ORF, which may affect the choice of vector (N/C terminal tag vector).

***One clone ID might be correlated to multiple accession numbers, which share the same CDS sequence.

Reference Sequences (Refseq)

PPP1R3C ( NM_005398.6 ) cDNA ORF clone, Homo sapiens(human) -> NP_005389.1 Homo sapiens protein phosphatase 1 regulatory subunit 3C (PPP1R3C), mRNA.

Price & Availability↑

CloneID	OHu55887
Clone ID Related Accession (Same CDS sequence)	NM_005398.6 , NM_005398.5 , NM_005398.7
Accession Version	NM_005398.6	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 954bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2017-09-13
Organism	Homo sapiens(human)
Product	protein phosphatase 1 regulatory subunit 3C
Comment	Comment: REVIEWED REFSEQ: This record has been curated by NCBI staff. The reference sequence was derived from BP202053.1, AK313149.1, BC012625.1, AI766011.1 and H14591.1. This sequence is a reference standard in the RefSeqGene project. On Sep 14, 2016 this sequence version replaced NM_005398.5. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: SRR1803614.113482.1, BX537399.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA2145544, SAMEA2155770 [ECO:0000348] ##Evidence-Data-END## COMPLETENESS: complete on the 3' end.

ATGAGCTGCA CCAGAATGAT CCAGGTTTTA GATCCACGTC CTTTGACAAG TTCGGTCATG 
CCCGTGGATG TGGCCATGAG GCTTTGCTTG GCACATTCAC CACCTGTGAA GAGTTTCCTG 
GGCCCGTACG ATGAATTTCA ACGACGACAT TTTGTGAATA AATTAAAGCC CCTGAAATCA 
TGTCTCAATA TAAAACACAA AGCCAAATCA CAGAATGACT GGAAGTGCTC ACACAACCAA 
GCCAAGAAGC GCGTTGTGTT TGCTGACTCC AAGGGCCTCT CTCTCACTGC GATCCATGTC 
TTCTCCGACC TCCCAGAAGA ACCAGCGTGG GATCTGCAGT TTGATCTCTT GGACCTTAAT 
GATATCTCCT CTGCCTTAAA ACACCACGAG GAGAAAAACT TGATTTTAGA TTTCCCTCAG 
CCTTCAACCG ATTACTTAAG TTTCCGGAGC CACTTTCAGA AGAACTTTGT CTGTCTGGAG 
AACTGCTCGT TGCAAGAGCG AACAGTGACA GGGACTGTTA AAGTCAAAAA TGTGAGTTTT 
GAGAAGAAAG TTCAGATCCG TATCACTTTC GATTCTTGGA AAAACTACAC TGACGTAGAC 
TGTGTCTATA TGAAAAATGT GTATGGTGGC ACAGATAGTG ATACCTTCTC ATTTGCCATT 
GACTTACCCC CTGTCATTCC AACTGAGCAG AAAATTGAGT TCTGCATTTC TTACCATGCT 
AATGGGCAAG TCTTTTGGGA CAACAATGAT GGTCAGAATT ATAGAATTGT TCATGTTCAA 
TGGAAGCCTG ATGGGGTGCA GACACAGATG GCACCCCAGG ACTGTGCATT CCACCAGACG 
TCTCCTAAGA CAGAGTTAGA GTCAACAATC TTTGGCAGTC CGAGGCTGGC TAGTGGGCTC 
TTCCCAGAGT GGCAGAGCTG GGGGAGAATG GAGAACTTGG CCTCTTATCG ATGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_005389.1
CDS	133..1086
Translation	MSCTRMIQVLDPRPLTSSVMPVDVAMRLCLAHSPPVKSFLGPYDEFQRRHFVNKLKPLKSCLNIKHKAKSQNDWKCSHNQAKKRVVFADSKGLSLTAIHVFSDLPEEPAWDLQFDLLDLNDISSALKHHEEKNLILDFPQPSTDYLSFRSHFQKNFVCLENCSLQERTVTGTVKVKNVSFEKKVQIRITFDSWKNYTDVDCVYMKNVYGGTDSDTFSFAIDLPPVIPTEQKIEFCISYHANGQVFWDNNDGQNYRIVHVQWKPDGVQTQMAPQDCAFHQTSPKTELESTIFGSPRLASGLFPEWQSWGRMENLASYR

Target ORF information:

RefSeq Version	NM_005398.6
Organism	Homo sapiens(human)
Definition	Homo sapiens protein phosphatase 1 regulatory subunit 3C (PPP1R3C), mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_005398.6

ORF Insert Sequence:

ATGAGCTGCA CCAGAATGAT CCAGGTTTTA GATCCACGTC CTTTGACAAG TTCGGTCATG 
CCCGTGGATG TGGCCATGAG GCTTTGCTTG GCACATTCAC CACCTGTGAA GAGTTTCCTG 
GGCCCGTACG ATGAATTTCA ACGACGACAT TTTGTGAATA AATTAAAGCC CCTGAAATCA 
TGTCTCAATA TAAAACACAA AGCCAAATCA CAGAATGACT GGAAGTGCTC ACACAACCAA 
GCCAAGAAGC GCGTTGTGTT TGCTGACTCC AAGGGCCTCT CTCTCACTGC GATCCATGTC 
TTCTCCGACC TCCCAGAAGA ACCAGCGTGG GATCTGCAGT TTGATCTCTT GGACCTTAAT 
GATATCTCCT CTGCCTTAAA ACACCACGAG GAGAAAAACT TGATTTTAGA TTTCCCTCAG 
CCTTCAACCG ATTACTTAAG TTTCCGGAGC CACTTTCAGA AGAACTTTGT CTGTCTGGAG 
AACTGCTCGT TGCAAGAGCG AACAGTGACA GGGACTGTTA AAGTCAAAAA TGTGAGTTTT 
GAGAAGAAAG TTCAGATCCG TATCACTTTC GATTCTTGGA AAAACTACAC TGACGTAGAC 
TGTGTCTATA TGAAAAATGT GTATGGTGGC ACAGATAGTG ATACCTTCTC ATTTGCCATT 
GACTTACCCC CTGTCATTCC AACTGAGCAG AAAATTGAGT TCTGCATTTC TTACCATGCT 
AATGGGCAAG TCTTTTGGGA CAACAATGAT GGTCAGAATT ATAGAATTGT TCATGTTCAA 
TGGAAGCCTG ATGGGGTGCA GACACAGATG GCACCCCAGG ACTGTGCATT CCACCAGACG 
TCTCCTAAGA CAGAGTTAGA GTCAACAATC TTTGGCAGTC CGAGGCTGGC TAGTGGGCTC 
TTCCCAGAGT GGCAGAGCTG GGGGAGAATG GAGAACTTGG CCTCTTATCG ATGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

PPP1R3C ( NM_005398.5 ) cDNA ORF clone, Homo sapiens(human) -> NP_005389.1 Homo sapiens protein phosphatase 1, regulatory subunit 3C (PPP1R3C), mRNA.

Price & Availability↑

CloneID	OHu55887
Clone ID Related Accession (Same CDS sequence)	NM_005398.6 , NM_005398.5 , NM_005398.7
Accession Version	NM_005398.5	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 954bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2015-03-14
Organism	Homo sapiens(Human)
Product	protein phosphatase 1 regulatory subunit 3C
Comment

ATGAGCTGCA CCAGAATGAT CCAGGTTTTA GATCCACGTC CTTTGACAAG TTCGGTCATG 
CCCGTGGATG TGGCCATGAG GCTTTGCTTG GCACATTCAC CACCTGTGAA GAGTTTCCTG 
GGCCCGTACG ATGAATTTCA ACGACGACAT TTTGTGAATA AATTAAAGCC CCTGAAATCA 
TGTCTCAATA TAAAACACAA AGCCAAATCA CAGAATGACT GGAAGTGCTC ACACAACCAA 
GCCAAGAAGC GCGTTGTGTT TGCTGACTCC AAGGGCCTCT CTCTCACTGC GATCCATGTC 
TTCTCCGACC TCCCAGAAGA ACCAGCGTGG GATCTGCAGT TTGATCTCTT GGACCTTAAT 
GATATCTCCT CTGCCTTAAA ACACCACGAG GAGAAAAACT TGATTTTAGA TTTCCCTCAG 
CCTTCAACCG ATTACTTAAG TTTCCGGAGC CACTTTCAGA AGAACTTTGT CTGTCTGGAG 
AACTGCTCGT TGCAAGAGCG AACAGTGACA GGGACTGTTA AAGTCAAAAA TGTGAGTTTT 
GAGAAGAAAG TTCAGATCCG TATCACTTTC GATTCTTGGA AAAACTACAC TGACGTAGAC 
TGTGTCTATA TGAAAAATGT GTATGGTGGC ACAGATAGTG ATACCTTCTC ATTTGCCATT 
GACTTACCCC CTGTCATTCC AACTGAGCAG AAAATTGAGT TCTGCATTTC TTACCATGCT 
AATGGGCAAG TCTTTTGGGA CAACAATGAT GGTCAGAATT ATAGAATTGT TCATGTTCAA 
TGGAAGCCTG ATGGGGTGCA GACACAGATG GCACCCCAGG ACTGTGCATT CCACCAGACG 
TCTCCTAAGA CAGAGTTAGA GTCAACAATC TTTGGCAGTC CGAGGCTGGC TAGTGGGCTC 
TTCCCAGAGT GGCAGAGCTG GGGGAGAATG GAGAACTTGG CCTCTTATCG ATGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_005389.1
Translation	MSCTRMIQVLDPRPLTSSVMPVDVAMRLCLAHSPPVKSFLGPYDEFQRRHFVNKLKPLKSCLNIKHKAKSQNDWKCSHNQAKKRVVFADSKGLSLTAIHVFSDLPEEPAWDLQFDLLDLNDISSALKHHEEKNLILDFPQPSTDYLSFRSHFQKNFVCLENCSLQERTVTGTVKVKNVSFEKKVQIRITFDSWKNYTDVDCVYMKNVYGGTDSDTFSFAIDLPPVIPTEQKIEFCISYHANGQVFWDNNDGQNYRIVHVQWKPDGVQTQMAPQDCAFHQTSPKTELESTIFGSPRLASGLFPEWQSWGRMENLASYR

Target ORF information:

RefSeq Version	NM_005398.5
Organism	Homo sapiens(Human)
Definition	Homo sapiens protein phosphatase 1, regulatory subunit 3C (PPP1R3C), mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_005398.5

ORF Insert Sequence:

ATGAGCTGCA CCAGAATGAT CCAGGTTTTA GATCCACGTC CTTTGACAAG TTCGGTCATG 
CCCGTGGATG TGGCCATGAG GCTTTGCTTG GCACATTCAC CACCTGTGAA GAGTTTCCTG 
GGCCCGTACG ATGAATTTCA ACGACGACAT TTTGTGAATA AATTAAAGCC CCTGAAATCA 
TGTCTCAATA TAAAACACAA AGCCAAATCA CAGAATGACT GGAAGTGCTC ACACAACCAA 
GCCAAGAAGC GCGTTGTGTT TGCTGACTCC AAGGGCCTCT CTCTCACTGC GATCCATGTC 
TTCTCCGACC TCCCAGAAGA ACCAGCGTGG GATCTGCAGT TTGATCTCTT GGACCTTAAT 
GATATCTCCT CTGCCTTAAA ACACCACGAG GAGAAAAACT TGATTTTAGA TTTCCCTCAG 
CCTTCAACCG ATTACTTAAG TTTCCGGAGC CACTTTCAGA AGAACTTTGT CTGTCTGGAG 
AACTGCTCGT TGCAAGAGCG AACAGTGACA GGGACTGTTA AAGTCAAAAA TGTGAGTTTT 
GAGAAGAAAG TTCAGATCCG TATCACTTTC GATTCTTGGA AAAACTACAC TGACGTAGAC 
TGTGTCTATA TGAAAAATGT GTATGGTGGC ACAGATAGTG ATACCTTCTC ATTTGCCATT 
GACTTACCCC CTGTCATTCC AACTGAGCAG AAAATTGAGT TCTGCATTTC TTACCATGCT 
AATGGGCAAG TCTTTTGGGA CAACAATGAT GGTCAGAATT ATAGAATTGT TCATGTTCAA 
TGGAAGCCTG ATGGGGTGCA GACACAGATG GCACCCCAGG ACTGTGCATT CCACCAGACG 
TCTCCTAAGA CAGAGTTAGA GTCAACAATC TTTGGCAGTC CGAGGCTGGC TAGTGGGCTC 
TTCCCAGAGT GGCAGAGCTG GGGGAGAATG GAGAACTTGG CCTCTTATCG ATGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

PPP1R3C ( NM_005398.7 ) cDNA ORF clone, Homo sapiens(human) -> NP_005389.1 Homo sapiens protein phosphatase 1 regulatory subunit 3C (PPP1R3C), mRNA.

Price & Availability↑

CloneID	OHu55887
Clone ID Related Accession (Same CDS sequence)	NM_005398.6 , NM_005398.5 , NM_005398.7
Accession Version	NM_005398.7 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 954bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2020-01-01
Organism	Homo sapiens(human)
Product	protein phosphatase 1 regulatory subunit 3C
Comment	Comment: REVIEWED REFSEQ: This record has been curated by NCBI staff. The reference sequence was derived from BP202053.1, AK313149.1, BC012625.1, AI766011.1 and H14591.1. This sequence is a reference standard in the RefSeqGene project. On Nov 23, 2018 this sequence version replaced NM_005398.6. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: BX537399.1, SRR1660807.165536.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA2145544, SAMEA2155770 [ECO:0000348] ##Evidence-Data-END## ##RefSeq-Attributes-START## MANE Ensembl match :: ENST00000238994.6/ ENSP00000238994.5 RefSeq Select criteria :: based on single protein-coding transcript ##RefSeq-Attributes-END## COMPLETENESS: full length.

ATGAGCTGCA CCAGAATGAT CCAGGTTTTA GATCCACGTC CTTTGACAAG TTCGGTCATG 
CCCGTGGATG TGGCCATGAG GCTTTGCTTG GCACATTCAC CACCTGTGAA GAGTTTCCTG 
GGCCCGTACG ATGAATTTCA ACGACGACAT TTTGTGAATA AATTAAAGCC CCTGAAATCA 
TGTCTCAATA TAAAACACAA AGCCAAATCA CAGAATGACT GGAAGTGCTC ACACAACCAA 
GCCAAGAAGC GCGTTGTGTT TGCTGACTCC AAGGGCCTCT CTCTCACTGC GATCCATGTC 
TTCTCCGACC TCCCAGAAGA ACCAGCGTGG GATCTGCAGT TTGATCTCTT GGACCTTAAT 
GATATCTCCT CTGCCTTAAA ACACCACGAG GAGAAAAACT TGATTTTAGA TTTCCCTCAG 
CCTTCAACCG ATTACTTAAG TTTCCGGAGC CACTTTCAGA AGAACTTTGT CTGTCTGGAG 
AACTGCTCGT TGCAAGAGCG AACAGTGACA GGGACTGTTA AAGTCAAAAA TGTGAGTTTT 
GAGAAGAAAG TTCAGATCCG TATCACTTTC GATTCTTGGA AAAACTACAC TGACGTAGAC 
TGTGTCTATA TGAAAAATGT GTATGGTGGC ACAGATAGTG ATACCTTCTC ATTTGCCATT 
GACTTACCCC CTGTCATTCC AACTGAGCAG AAAATTGAGT TCTGCATTTC TTACCATGCT 
AATGGGCAAG TCTTTTGGGA CAACAATGAT GGTCAGAATT ATAGAATTGT TCATGTTCAA 
TGGAAGCCTG ATGGGGTGCA GACACAGATG GCACCCCAGG ACTGTGCATT CCACCAGACG 
TCTCCTAAGA CAGAGTTAGA GTCAACAATC TTTGGCAGTC CGAGGCTGGC TAGTGGGCTC 
TTCCCAGAGT GGCAGAGCTG GGGGAGAATG GAGAACTTGG CCTCTTATCG ATGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_005389.1
CDS	103..1056
Translation	MSCTRMIQVLDPRPLTSSVMPVDVAMRLCLAHSPPVKSFLGPYDEFQRRHFVNKLKPLKSCLNIKHKAKSQNDWKCSHNQAKKRVVFADSKGLSLTAIHVFSDLPEEPAWDLQFDLLDLNDISSALKHHEEKNLILDFPQPSTDYLSFRSHFQKNFVCLENCSLQERTVTGTVKVKNVSFEKKVQIRITFDSWKNYTDVDCVYMKNVYGGTDSDTFSFAIDLPPVIPTEQKIEFCISYHANGQVFWDNNDGQNYRIVHVQWKPDGVQTQMAPQDCAFHQTSPKTELESTIFGSPRLASGLFPEWQSWGRMENLASYR

Target ORF information:

RefSeq Version	NM_005398.7
Organism	Homo sapiens(human)
Definition	Homo sapiens protein phosphatase 1 regulatory subunit 3C (PPP1R3C), mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_005398.7

ORF Insert Sequence:

ATGAGCTGCA CCAGAATGAT CCAGGTTTTA GATCCACGTC CTTTGACAAG TTCGGTCATG 
CCCGTGGATG TGGCCATGAG GCTTTGCTTG GCACATTCAC CACCTGTGAA GAGTTTCCTG 
GGCCCGTACG ATGAATTTCA ACGACGACAT TTTGTGAATA AATTAAAGCC CCTGAAATCA 
TGTCTCAATA TAAAACACAA AGCCAAATCA CAGAATGACT GGAAGTGCTC ACACAACCAA 
GCCAAGAAGC GCGTTGTGTT TGCTGACTCC AAGGGCCTCT CTCTCACTGC GATCCATGTC 
TTCTCCGACC TCCCAGAAGA ACCAGCGTGG GATCTGCAGT TTGATCTCTT GGACCTTAAT 
GATATCTCCT CTGCCTTAAA ACACCACGAG GAGAAAAACT TGATTTTAGA TTTCCCTCAG 
CCTTCAACCG ATTACTTAAG TTTCCGGAGC CACTTTCAGA AGAACTTTGT CTGTCTGGAG 
AACTGCTCGT TGCAAGAGCG AACAGTGACA GGGACTGTTA AAGTCAAAAA TGTGAGTTTT 
GAGAAGAAAG TTCAGATCCG TATCACTTTC GATTCTTGGA AAAACTACAC TGACGTAGAC 
TGTGTCTATA TGAAAAATGT GTATGGTGGC ACAGATAGTG ATACCTTCTC ATTTGCCATT 
GACTTACCCC CTGTCATTCC AACTGAGCAG AAAATTGAGT TCTGCATTTC TTACCATGCT 
AATGGGCAAG TCTTTTGGGA CAACAATGAT GGTCAGAATT ATAGAATTGT TCATGTTCAA 
TGGAAGCCTG ATGGGGTGCA GACACAGATG GCACCCCAGG ACTGTGCATT CCACCAGACG 
TCTCCTAAGA CAGAGTTAGA GTCAACAATC TTTGGCAGTC CGAGGCTGGC TAGTGGGCTC 
TTCCCAGAGT GGCAGAGCTG GGGGAGAATG GAGAACTTGG CCTCTTATCG ATGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

PubMed

Architecture of the human interactome defines protein communities and disease networks.
Nature545(7655)505-509(2017 05)
Huttlin EL,Bruckner RJ,Paulo JA,Cannon JR,Ting L,Baltier K,Colby G,Gebreab F,Gygi MP,Parzen H,Szpyt J,Tam S,Zarraga G,Pontano-Vaites L,Swarup S,White AE,Schweppe DK,Rad R,Erickson BK,Obar RA,Guruharsha KG,Li K,Artavanis-Tsakonas S,Gygi SP,Harper JW

Systematic Analysis of Human Protein Phosphatase Interactions and Dynamics.
Cell systems4(4)430-444.e5(2017 Apr)
Yadav L,Tamene F,G??s H,van Drogen A,Katainen R,Aebersold R,Gstaiger M,Varjosalo M

Role of glycogen phosphorylase in liver glycogen metabolism.
Molecular aspects of medicine4634-45(2015 Dec)
Agius L

The effect of high glucose levels on the hypermethylation of protein phosphatase 1 regulatory subunit 3C (PPP1R3C) gene in colorectal cancer.
Journal of genetics94(1)75-85(2015 Mar)
Lee SK,Moon JW,Lee YW,Lee JO,Kim SJ,Kim N,Kim J,Kim HS,Park SH

Aberrant promoter methylation of PPP1R3C and EFHD1 in plasma of colorectal cancer patients.
Cancer medicine3(5)1235-45(2014 Oct)
Takane K,Midorikawa Y,Yagi K,Sakai A,Aburatani H,Takayama T,Kaneda A

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PPP1R3C cDNA ORF clone, Homo sapiens(human)

Gene

Clones

gRNAs

Related articles in PubMed

Target ORF information:

Target ORF information:

ORF Insert Sequence:

Target ORF information:

Target ORF information:

ORF Insert Sequence:

Target ORF information:

Target ORF information:

ORF Insert Sequence:

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