TMEM70 cDNA ORF clone, Homo sapiens(human)

Gene
Clones
gRNAs

Summary

Gene Symbol	TMEM70
Entrez Gene ID	54968
Full Name	transmembrane protein 70
Synonyms	MC5DN2
General protein information	Preferred Names transmembrane protein 70 Names transmembrane protein 70, mitochondrial
Gene Type	protein-coding
Organism	Homo sapiens(human)
Genome	Chromosome: 8 Map Location: 8q21.11
Summary	This gene likely encodes a mitochondrial membrane protein. The encoded protein may play a role in biogenesis of mitochondrial ATP synthase. Mutations in this gene have been associated with neonatal mitochondrial encephalocardiomyopathy due to ATP synthase deficiency. Alternatively spliced transcript variants have been described. [provided by RefSeq, Feb 2010].
Disorder MIM:	612418
Disorder Html:	Mitochondrial complex V (ATP synthase) deficiency, nuclear type 2, 614052 (3)

mRNA and Protein(s)

mRNA	Protein	Name
NM_017866.5	NP_060336.3	transmembrane protein 70, mitochondrial isoform a
NM_001040613.2	NP_001035703.1	transmembrane protein 70, mitochondrial isoform b
NM_017866.6	NP_060336.3	transmembrane protein 70, mitochondrial isoform a

Pathways from BioSystems

Homologies

Gallus gallus (chicken)	TMEM70	NP_001012866.1
Mus musculus (house mouse)	Tmem70	NP_080668.1
Bos taurus (cattle)	TMEM70	NP_001092596.1
Rattus norvegicus (Norway rat)	Tmem70	NP_001102728.1
Homo sapiens (human)	TMEM70	NP_060336.3
Drosophila melanogaster (fruit fly)	CG7506	NP_648144.3
Anopheles gambiae (African malaria mosquito)	AgaP_AGAP004903	XP_314994.4
	TMEM70	XP_001086185.1
Canis lupus familiaris (dog)	TMEM70	XP_005638209.1
Danio rerio (zebrafish)	tmem70	XP_002660878.1
Xenopus tropicalis (tropical clawed frog)	tmem70	XP_002937119.1

Gene Ontology
Bibliography

Related articles in PubMed

Dual LQT1 and HCM phenotypes associated with tetrad heterozygous mutations in KCNQ1, MYH7, MYLK2, and TMEM70 genes in a three-generation Chinese family.
Wang L, Zuo L, Hu J, Shao H, Lei C, Qi W, Liu Y, Miao Y, Ma X, Huang CL, Wang B, Zhou X, Zhang Y, Liu L
Europace : European pacing, arrhythmias, and cardiac electrophysiology : journal of the working groups on cardiac pacing, arrhythmias, and cardiac cellular electrophysiology of the European Society of Cardiology18(4)602-9(2016 Apr)

TMEM70 deficiency: long-term outcome of 48 patients.
Magner M, Dvorakova V, Tesarova M, Mazurova S, Hansikova H, Zahorec M, Brennerova K, Bzduch V, Spiegel R, Horovitz Y, Mandel H, Emino?lu FT, Mayr JA, Koch J, Martinelli D, Bertini E, Konstantopoulou V, Smet J, Rahman S, Broomfield A, Stojanovi? V, Dionisi-Vici C, van Coster R, Morava E, Morava-Kozicz E, Sperl W, Zeman J, Honzik T
Journal of inherited metabolic disease38(3)417-26(2015 May)

ATP synthase deficiency due to TMEM70 mutation leads to ultrastructural mitochondrial degeneration and is amenable to treatment.
Braczynski AK, Vlaho S, M?ller K, Wittig I, Blank AE, Tews DS, Drott U, Kleinle S, Abicht A, Horvath R, Plate KH, Stenzel W, Goebel HH, Schulze A, Harter PN, Kieslich M, Mittelbronn M
BioMed research international2015462592(2015)

Mitochondrial membrane assembly of TMEM70 protein.
Kratochv?lov? H, Hejzlarov? K, Vrback? M, Mr??ek T, Karbanov? V, Tesa?ov? M, Gombitov? A, Cmarko D, Wittig I, Zeman J, Hou?t?k J
Mitochondrion151-9(2014 Mar)

Mitochondrial encephalocardio-myopathy with early neonatal onset due to TMEM70 mutation.
Honz?k T, Tesarov? M, Mayr JA, Hans?kov? H, Jesina P, Bodamer O, Koch J, Magner M, Freisinger P, Huemer M, Kostkov? O, van Coster R, Kmoch S, Houst?k J, Sperl W, Zeman J
Archives of disease in childhood95(4)296-301(2010 Apr)

GeneRIFs: Gene References Into Functions What's a GeneRIF?

Chinese family with dual LQT1 and HCM phenotypes associated with tetrad heterozygous mutations in KCNQ1, MYH7, MYLK2, and TMEM70 mutations.
Title: Dual LQT1 and HCM phenotypes associated with tetrad heterozygous mutations in KCNQ1, MYH7, MYLK2, and TMEM70 genes in a three-generation Chinese family.

TMEM70 deficiency is a panethnic, multisystemic disease with variable outcome depending mainly on adequate management of hyperammonaemic crises in the neonatal period and early childhood.
Title: TMEM70 deficiency: long-term outcome of 48 patients.

In summary, TMEM70 mutations can cause distinct ultrastructural mitochondrial degeneration and almost complete deficiency of ATP synthase but are still amenable to treatment.
Title: ATP synthase deficiency due to TMEM70 mutation leads to ultrastructural mitochondrial degeneration and is amenable to treatment.

These data indicate that the biological function of TMEM70 in the ATP synthase biogenesis may be mediated through interaction with other protein(s).
Title: Mitochondrial membrane assembly of TMEM70 protein.

Pulmonary hypertension has rarely been reported in mitochondrial disorders and, so far, it has been described in association with TMEM70 deficiency only in one patient
Title: Persistent pulmonary arterial hypertension in the newborn (PPHN): a frequent manifestation of TMEM70 defective patients.

The following TMEM70 gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the TMEM70 cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1⁺/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.

***CloneID	Accession No.	Definition	**Vector	*Turnaround time	Price (USD)
OHu17902	NM_001040613.2 Latest version!	Homo sapiens transmembrane protein 70 (TMEM70), transcript variant 2, mRNA.	pcDNA3.1-C-(k)DYK or customized vector	in pcDNA3.1-C-(k)DYK	$49.50-$69.30 $99.00
OHu32317	NM_017866.6 Latest version!	Homo sapiens transmembrane protein 70 (TMEM70), transcript variant 1, mRNA.	pcDNA3.1-C-(k)DYK or customized vector	in pcDNA3.1-C-(k)DYK	$49.50-$69.30 $99.00
View Old Accession Versions >>
OHu32317	NM_017866.5	Homo sapiens transmembrane protein 70 (TMEM70), transcript variant 1, mRNA.	pcDNA3.1-C-(k)DYK or customized vector	in pcDNA3.1-C-(k)DYK	$49.50-$69.30 $99.00
Hide Old Accession Versions >>

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** GenScript guarantees 100% sequence accuracy of all synthetic DNA constructs we deliver, but we do not guarantee protein expression in your experimental system. Protein expression is influenced by many factors that may vary between experiments or laboratories. In addition, please pay attention to the signal peptide, propeptide and transit peptide in target ORF, which may affect the choice of vector (N/C terminal tag vector).

***One clone ID might be correlated to multiple accession numbers, which share the same CDS sequence.

Reference Sequences (Refseq)

TMEM70 ( NM_001040613.2 ) cDNA ORF clone, Homo sapiens(human) -> NP_001035703.1 Homo sapiens transmembrane protein 70 (TMEM70), transcript variant 2, mRNA.

Price & Availability↑

CloneID	OHu17902
Clone ID Related Accession (Same CDS sequence)	NM_001040613.2
Accession Version	NM_001040613.2 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 324bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2018-06-23
Organism	Homo sapiens(human)
Product	transmembrane protein 70, mitochondrial isoform b
Comment	Comment: REVIEWED REFSEQ: This record has been curated by NCBI staff. The reference sequence was derived from DB483583.1, BF439499.1, BC002748.2 and BM984431.1. This sequence is a reference standard in the RefSeqGene project. On Feb 20, 2010 this sequence version replaced NM_001040613.1. Transcript Variant: This variant (2) uses an alternate splice site in the 3' coding region, which results in a frameshift, compared to variant 1. It encodes isoform b, which has a shorter and distinct C-terminus, compared to isoform a. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: SRR1660803.151458.1, AI800622.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA1966682, SAMEA1968189 [ECO:0000348] ##Evidence-Data-END## ##RefSeq-Attributes-START## gene product(s) localized to mito. :: PMID: 16582907; reported by MitoCarta ##RefSeq-Attributes-END## COMPLETENESS: complete on the 3' end.

ATGCTGTTTC TGGCGTTGGG CAGCCCGTGG GCGGTCGAAC TGCCTCTCTG CGGAAGGAGG 
ACTGCATTGT GTGCGGCCGC CGCGCTCCGA GGTCCCCGGG CCTCTGTCTC CCGGGCGTCC 
TCCAGCAGCG GGCCTTCGGG GCCGGTAGCC GGCTGGAGTA CGGGGCCTTC GGGAGCCGCG 
CGCCTTCTCC GGCGTCCGGG TCGAGCGCAG ATCCCTGTTT ATTGGGAAGG ATATGTTCGA 
TTCTTAAATA CGCCATCTGA CAAATCAGAA GATGGAAGGC TAATTTATAC TGGCAATATG 
GCCCGAGCAG TGTTTGGTAA GTAA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_001035703.1
CDS	141..464
Translation	MLFLALGSPWAVELPLCGRRTALCAAAALRGPRASVSRASSSSGPSGPVAGWSTGPSGAARLLRRPGRAQIPVYWEGYVRFLNTPSDKSEDGRLIYTGNMARAVFGK

Target ORF information:

RefSeq Version	NM_001040613.2
Organism	Homo sapiens(human)
Definition	Homo sapiens transmembrane protein 70 (TMEM70), transcript variant 2, mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_001040613.2

ORF Insert Sequence:

ATGCTGTTTC TGGCGTTGGG CAGCCCGTGG GCGGTCGAAC TGCCTCTCTG CGGAAGGAGG 
ACTGCATTGT GTGCGGCCGC CGCGCTCCGA GGTCCCCGGG CCTCTGTCTC CCGGGCGTCC 
TCCAGCAGCG GGCCTTCGGG GCCGGTAGCC GGCTGGAGTA CGGGGCCTTC GGGAGCCGCG 
CGCCTTCTCC GGCGTCCGGG TCGAGCGCAG ATCCCTGTTT ATTGGGAAGG ATATGTTCGA 
TTCTTAAATA CGCCATCTGA CAAATCAGAA GATGGAAGGC TAATTTATAC TGGCAATATG 
GCCCGAGCAG TGTTTGGTAA GTAA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

TMEM70 ( NM_017866.5 ) cDNA ORF clone, Homo sapiens(human) -> NP_060336.3 Homo sapiens transmembrane protein 70 (TMEM70), transcript variant 1, mRNA.

Price & Availability↑

CloneID	OHu32317
Clone ID Related Accession (Same CDS sequence)	NM_017866.5 , NM_017866.6
Accession Version	NM_017866.5	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 783bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2017-10-01
Organism	Homo sapiens(human)
Product	transmembrane protein 70, mitochondrial isoform a
Comment	Comment: REVIEWED REFSEQ: This record has been curated by NCBI staff. The reference sequence was derived from DB483583.1, BC002748.2 and BM984431.1. On Feb 20, 2010 this sequence version replaced NM_017866.4. Transcript Variant: This variant (1) represents the shortest transcript and encodes the longer isoform (a). Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: BC002748.2, SRR1660805.162630.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA1965299, SAMEA1966682 [ECO:0000348] ##Evidence-Data-END## ##RefSeq-Attributes-START## gene product(s) localized to mito. :: PMID: 16582907; reported by MitoCarta ##RefSeq-Attributes-END## COMPLETENESS: complete on the 3' end.

ATGCTGTTTC TGGCGTTGGG CAGCCCGTGG GCGGTCGAAC TGCCTCTCTG CGGAAGGAGG 
ACTGCATTGT GTGCGGCCGC CGCGCTCCGA GGTCCCCGGG CCTCTGTCTC CCGGGCGTCC 
TCCAGCAGCG GGCCTTCGGG GCCGGTAGCC GGCTGGAGTA CGGGGCCTTC GGGAGCCGCG 
CGCCTTCTCC GGCGTCCGGG TCGAGCGCAG ATCCCTGTTT ATTGGGAAGG ATATGTTCGA 
TTCTTAAATA CGCCATCTGA CAAATCAGAA GATGGAAGGC TAATTTATAC TGGCAATATG 
GCCCGAGCAG TGTTTGGTGT GAAATGTTTC TCTTATTCTA CGAGTCTGAT TGGCCTTACA 
TTTCTGCCAT ACATTTTTAC ACAAAATAAT GCTATTTCTG AAAGTGTGCC TCTGCCTATT 
CAAATCATAT TCTATGGCAT CATGGGAAGC TTTACGGTGA TCACCCCAGT GCTGCTTCAC 
TTTATTACAA AAGGCTATGT CATTCGATTG TACCATGAGG CCACAACAGA CACTTATAAA 
GCCATTACCT ACAATGCTAT GCTTGCAGAA ACGAGTACAG TGTTTCACCA GAATGATGTG 
AAGATTCCAG ATGCTAAACA TGTATTTACC ACATTTTATG CTAAAACAAA ATCACTGTTA 
GTTAATCCAG TGCTCTTTCC AAACCGTGAA GACTATATCC ATCTAATGGG TTATGACAAA 
GAAGAATTTA TTTTGTATAT GGAAGAAACC AGTGAAGAGA AACGGCATAA AGATGACAAA 
TGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_060336.3
CDS	141..923
Translation	MLFLALGSPWAVELPLCGRRTALCAAAALRGPRASVSRASSSSGPSGPVAGWSTGPSGAARLLRRPGRAQIPVYWEGYVRFLNTPSDKSEDGRLIYTGNMARAVFGVKCFSYSTSLIGLTFLPYIFTQNNAISESVPLPIQIIFYGIMGSFTVITPVLLHFITKGYVIRLYHEATTDTYKAITYNAMLAETSTVFHQNDVKIPDAKHVFTTFYAKTKSLLVNPVLFPNREDYIHLMGYDKEEFILYMEETSEEKRHKDDK

Target ORF information:

RefSeq Version	NM_017866.5
Organism	Homo sapiens(human)
Definition	Homo sapiens transmembrane protein 70 (TMEM70), transcript variant 1, mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_017866.5

ORF Insert Sequence:

ATGCTGTTTC TGGCGTTGGG CAGCCCGTGG GCGGTCGAAC TGCCTCTCTG CGGAAGGAGG 
ACTGCATTGT GTGCGGCCGC CGCGCTCCGA GGTCCCCGGG CCTCTGTCTC CCGGGCGTCC 
TCCAGCAGCG GGCCTTCGGG GCCGGTAGCC GGCTGGAGTA CGGGGCCTTC GGGAGCCGCG 
CGCCTTCTCC GGCGTCCGGG TCGAGCGCAG ATCCCTGTTT ATTGGGAAGG ATATGTTCGA 
TTCTTAAATA CGCCATCTGA CAAATCAGAA GATGGAAGGC TAATTTATAC TGGCAATATG 
GCCCGAGCAG TGTTTGGTGT GAAATGTTTC TCTTATTCTA CGAGTCTGAT TGGCCTTACA 
TTTCTGCCAT ACATTTTTAC ACAAAATAAT GCTATTTCTG AAAGTGTGCC TCTGCCTATT 
CAAATCATAT TCTATGGCAT CATGGGAAGC TTTACGGTGA TCACCCCAGT GCTGCTTCAC 
TTTATTACAA AAGGCTATGT CATTCGATTG TACCATGAGG CCACAACAGA CACTTATAAA 
GCCATTACCT ACAATGCTAT GCTTGCAGAA ACGAGTACAG TGTTTCACCA GAATGATGTG 
AAGATTCCAG ATGCTAAACA TGTATTTACC ACATTTTATG CTAAAACAAA ATCACTGTTA 
GTTAATCCAG TGCTCTTTCC AAACCGTGAA GACTATATCC ATCTAATGGG TTATGACAAA 
GAAGAATTTA TTTTGTATAT GGAAGAAACC AGTGAAGAGA AACGGCATAA AGATGACAAA 
TGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

TMEM70 ( NM_017866.6 ) cDNA ORF clone, Homo sapiens(human) -> NP_060336.3 Homo sapiens transmembrane protein 70 (TMEM70), transcript variant 1, mRNA.

Price & Availability↑

CloneID	OHu32317
Clone ID Related Accession (Same CDS sequence)	NM_017866.5 , NM_017866.6
Accession Version	NM_017866.6 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 783bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-05-01
Organism	Homo sapiens(human)
Product	transmembrane protein 70, mitochondrial isoform a
Comment	Comment: REVIEWED REFSEQ: This record has been curated by NCBI staff. The reference sequence was derived from DB483583.1, BC002748.2 and BM984431.1. On Nov 23, 2018 this sequence version replaced NM_017866.5. Transcript Variant: This variant (1) represents the shortest transcript and encodes the longer isoform (a). Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: SRR3476690.1029391.1, SRR1660805.162630.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA1965299, SAMEA1966682 [ECO:0000348] ##Evidence-Data-END## ##RefSeq-Attributes-START## gene product(s) localized to mito. :: PMID: 16582907; reported by MitoCarta MANE Ensembl match :: ENST00000312184.6/ ENSP00000312599.5 RefSeq Select criteria :: based on conservation, expression, longest protein ##RefSeq-Attributes-END## COMPLETENESS: full length.

ATGCTGTTTC TGGCGTTGGG CAGCCCGTGG GCGGTCGAAC TGCCTCTCTG CGGAAGGAGG 
ACTGCATTGT GTGCGGCCGC CGCGCTCCGA GGTCCCCGGG CCTCTGTCTC CCGGGCGTCC 
TCCAGCAGCG GGCCTTCGGG GCCGGTAGCC GGCTGGAGTA CGGGGCCTTC GGGAGCCGCG 
CGCCTTCTCC GGCGTCCGGG TCGAGCGCAG ATCCCTGTTT ATTGGGAAGG ATATGTTCGA 
TTCTTAAATA CGCCATCTGA CAAATCAGAA GATGGAAGGC TAATTTATAC TGGCAATATG 
GCCCGAGCAG TGTTTGGTGT GAAATGTTTC TCTTATTCTA CGAGTCTGAT TGGCCTTACA 
TTTCTGCCAT ACATTTTTAC ACAAAATAAT GCTATTTCTG AAAGTGTGCC TCTGCCTATT 
CAAATCATAT TCTATGGCAT CATGGGAAGC TTTACGGTGA TCACCCCAGT GCTGCTTCAC 
TTTATTACAA AAGGCTATGT CATTCGATTG TACCATGAGG CCACAACAGA CACTTATAAA 
GCCATTACCT ACAATGCTAT GCTTGCAGAA ACGAGTACAG TGTTTCACCA GAATGATGTG 
AAGATTCCAG ATGCTAAACA TGTATTTACC ACATTTTATG CTAAAACAAA ATCACTGTTA 
GTTAATCCAG TGCTCTTTCC AAACCGTGAA GACTATATCC ATCTAATGGG TTATGACAAA 
GAAGAATTTA TTTTGTATAT GGAAGAAACC AGTGAAGAGA AACGGCATAA AGATGACAAA 
TGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_060336.3
CDS	88..870
Translation	MLFLALGSPWAVELPLCGRRTALCAAAALRGPRASVSRASSSSGPSGPVAGWSTGPSGAARLLRRPGRAQIPVYWEGYVRFLNTPSDKSEDGRLIYTGNMARAVFGVKCFSYSTSLIGLTFLPYIFTQNNAISESVPLPIQIIFYGIMGSFTVITPVLLHFITKGYVIRLYHEATTDTYKAITYNAMLAETSTVFHQNDVKIPDAKHVFTTFYAKTKSLLVNPVLFPNREDYIHLMGYDKEEFILYMEETSEEKRHKDDK

Target ORF information:

RefSeq Version	NM_017866.6
Organism	Homo sapiens(human)
Definition	Homo sapiens transmembrane protein 70 (TMEM70), transcript variant 1, mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_017866.6

ORF Insert Sequence:

ATGCTGTTTC TGGCGTTGGG CAGCCCGTGG GCGGTCGAAC TGCCTCTCTG CGGAAGGAGG 
ACTGCATTGT GTGCGGCCGC CGCGCTCCGA GGTCCCCGGG CCTCTGTCTC CCGGGCGTCC 
TCCAGCAGCG GGCCTTCGGG GCCGGTAGCC GGCTGGAGTA CGGGGCCTTC GGGAGCCGCG 
CGCCTTCTCC GGCGTCCGGG TCGAGCGCAG ATCCCTGTTT ATTGGGAAGG ATATGTTCGA 
TTCTTAAATA CGCCATCTGA CAAATCAGAA GATGGAAGGC TAATTTATAC TGGCAATATG 
GCCCGAGCAG TGTTTGGTGT GAAATGTTTC TCTTATTCTA CGAGTCTGAT TGGCCTTACA 
TTTCTGCCAT ACATTTTTAC ACAAAATAAT GCTATTTCTG AAAGTGTGCC TCTGCCTATT 
CAAATCATAT TCTATGGCAT CATGGGAAGC TTTACGGTGA TCACCCCAGT GCTGCTTCAC 
TTTATTACAA AAGGCTATGT CATTCGATTG TACCATGAGG CCACAACAGA CACTTATAAA 
GCCATTACCT ACAATGCTAT GCTTGCAGAA ACGAGTACAG TGTTTCACCA GAATGATGTG 
AAGATTCCAG ATGCTAAACA TGTATTTACC ACATTTTATG CTAAAACAAA ATCACTGTTA 
GTTAATCCAG TGCTCTTTCC AAACCGTGAA GACTATATCC ATCTAATGGG TTATGACAAA 
GAAGAATTTA TTTTGTATAT GGAAGAAACC AGTGAAGAGA AACGGCATAA AGATGACAAA 
TGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

PubMed

Dual LQT1 and HCM phenotypes associated with tetrad heterozygous mutations in KCNQ1, MYH7, MYLK2, and TMEM70 genes in a three-generation Chinese family.
Europace : European pacing, arrhythmias, and cardiac electrophysiology : journal of the working groups on cardiac pacing, arrhythmias, and cardiac cellular electrophysiology of the European Society of Cardiology18(4)602-9(2016 Apr)
Wang L,Zuo L,Hu J,Shao H,Lei C,Qi W,Liu Y,Miao Y,Ma X,Huang CL,Wang B,Zhou X,Zhang Y,Liu L

TMEM70 deficiency: long-term outcome of 48 patients.
Journal of inherited metabolic disease38(3)417-26(2015 May)
Magner M,Dvorakova V,Tesarova M,Mazurova S,Hansikova H,Zahorec M,Brennerova K,Bzduch V,Spiegel R,Horovitz Y,Mandel H,Emino?lu FT,Mayr JA,Koch J,Martinelli D,Bertini E,Konstantopoulou V,Smet J,Rahman S,Broomfield A,Stojanovi? V,Dionisi-Vici C,van Coster R,Morava E,Morava-Kozicz E,Sperl W,Zeman J,Honzik T

ATP synthase deficiency due to TMEM70 mutation leads to ultrastructural mitochondrial degeneration and is amenable to treatment.
BioMed research international2015462592(2015)
Braczynski AK,Vlaho S,M?ller K,Wittig I,Blank AE,Tews DS,Drott U,Kleinle S,Abicht A,Horvath R,Plate KH,Stenzel W,Goebel HH,Schulze A,Harter PN,Kieslich M,Mittelbronn M

Mitochondrial membrane assembly of TMEM70 protein.
Mitochondrion151-9(2014 Mar)
Kratochv?lov? H,Hejzlarov? K,Vrback? M,Mr??ek T,Karbanov? V,Tesa?ov? M,Gombitov? A,Cmarko D,Wittig I,Zeman J,Hou?t?k J

Mitochondrial encephalocardio-myopathy with early neonatal onset due to TMEM70 mutation.
Archives of disease in childhood95(4)296-301(2010 Apr)
Honz?k T,Tesarov? M,Mayr JA,Hans?kov? H,Jesina P,Bodamer O,Koch J,Magner M,Freisinger P,Huemer M,Kostkov? O,van Coster R,Kmoch S,Houst?k J,Sperl W,Zeman J

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TMEM70 cDNA ORF clone, Homo sapiens(human)

Gene

Clones

gRNAs

Related articles in PubMed

Target ORF information:

Target ORF information:

ORF Insert Sequence:

Target ORF information:

Target ORF information:

ORF Insert Sequence:

Target ORF information:

Target ORF information:

ORF Insert Sequence:

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Services & Products

見積依頼

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電話

FAX

オンラインフォーム