MRPL16 cDNA ORF clone, Homo sapiens(human)

Gene
Clones
gRNAs

Summary

Gene Symbol	MRPL16
Entrez Gene ID	54948
Full Name	mitochondrial ribosomal protein L16
Synonyms	L16mt,MRP-L16,PNAS-111
General protein information	Preferred Names mitochondrial ribosomal protein L16 Names 39S ribosomal protein L16, mitochondrial mitochondrial large ribosomal subunit protein uL16m
Gene Type	protein-coding
Organism	Homo sapiens(human)
Genome	Chromosome: 11 Map Location: 11q12.1
Summary	Mammalian mitochondrial ribosomal proteins are encoded by nuclear genes and help in protein synthesis within the mitochondrion. Mitochondrial ribosomes (mitoribosomes) consist of a small 28S subunit and a large 39S subunit. They have an estimated 75% protein to rRNA composition compared to prokaryotic ribosomes, where this ratio is reversed. Another difference between mammalian mitoribosomes and prokaryotic ribosomes is that the latter contain a 5S rRNA. Among different species, the proteins comprising the mitoribosome differ greatly in sequence, and sometimes in biochemical properties, which prevents easy recognition by sequence homology. This gene encodes a 39S subunit protein. [provided by RefSeq, Jul 2008].
Disorder MIM:	611829

mRNA and Protein(s)

mRNA	Protein	Name
NM_017840.3	NP_060310.1	39S ribosomal protein L16, mitochondrial
NM_017840.4	NP_060310.1	39S ribosomal protein L16, mitochondrial

Pathways from BioSystems

Homologies

Pan troglodytes (chimpanzee)	MRPL16	XP_508452.2
Rattus norvegicus (Norway rat)	Mrpl16	NP_001009647.1
Danio rerio (zebrafish)	mrpl16	NP_001007765.1
Homo sapiens (human)	MRPL16	NP_060310.1
Drosophila melanogaster (fruit fly)	mRpL16	NP_001259148.1
	MRPL16	XP_001089378.1
Anopheles gambiae (African malaria mosquito)	AgaP_AGAP004985	XP_315089.3
Canis lupus familiaris (dog)	MRPL16	XP_003639835.1
Canis lupus familiaris (dog)	LOC100855841	XP_003640356.2
Bos taurus (cattle)	MRPL16	NP_001029813.1
Xenopus tropicalis (tropical clawed frog)	LOC101731117	XP_004916539.1
Xenopus tropicalis (tropical clawed frog)	mrpl16	NP_001017058.1
Mus musculus (house mouse)	Mrpl16	NP_079882.2
Gallus gallus (chicken)	MRPL16	XP_426396.3
Caenorhabditis elegans (roundworm)	mrpl-16	NP_497965.2

Gene Ontology
Bibliography

Related articles in PubMed

Structures of the human mitochondrial ribosome in native states of assembly.
Brown A, Rathore S, Kimanius D, Aibara S, Bai XC, Rorbach J, Amunts A, Ramakrishnan V
Nature structural & molecular biology24(10)866-869(2017 Oct)

Variability of Gene Expression Identifies Transcriptional Regulators of Early Human Embryonic Development.
Hasegawa Y, Taylor D, Ovchinnikov DA, Wolvetang EJ, de Torrent? L, Mar JC
PLoS genetics11(8)e1005428(2015 Aug)

Structure of the large ribosomal subunit from human mitochondria.
Brown A, Amunts A, Bai XC, Sugimoto Y, Edwards PC, Murshudov G, Scheres SHW, Ramakrishnan V
Science (New York, N.Y.)346(6210)718-722(2014 Nov)

Genetic variants in nuclear-encoded mitochondrial genes influence AIDS progression.
Hendrickson SL, Lautenberger JA, Chinn LW, Malasky M, Sezgin E, Kingsley LA, Goedert JJ, Kirk GD, Gomperts ED, Buchbinder SP, Troyer JL, O'Brien SJ
PloS one5(9)e12862(2010 Sep)

Identification and characterization of over 100 mitochondrial ribosomal protein pseudogenes in the human genome.
Zhang Z, Gerstein M
Genomics81(5)468-80(2003 May)

GeneRIFs: Gene References Into Functions What's a GeneRIF?

Observational study of gene-disease association. (HuGE Navigator)
Title: Genetic variants in nuclear-encoded mitochondrial genes influence AIDS progression.

The following MRPL16 gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the MRPL16 cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1⁺/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.

***CloneID	Accession No.	Definition	**Vector	*Turnaround time	Price (USD)
OHu09005	NM_017840.4 Latest version!	Homo sapiens mitochondrial ribosomal protein L16 (MRPL16), mRNA.	pcDNA3.1-C-(k)DYK or customized vector	in pcDNA3.1-C-(k)DYK	$49.50-$69.30 $99.00
View Old Accession Versions >>
OHu09005	NM_017840.3	Homo sapiens mitochondrial ribosomal protein L16 (MRPL16), mRNA.	pcDNA3.1-C-(k)DYK or customized vector	in pcDNA3.1-C-(k)DYK	$49.50-$69.30 $99.00
Hide Old Accession Versions >>

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** GenScript guarantees 100% sequence accuracy of all synthetic DNA constructs we deliver, but we do not guarantee protein expression in your experimental system. Protein expression is influenced by many factors that may vary between experiments or laboratories. In addition, please pay attention to the signal peptide, propeptide and transit peptide in target ORF, which may affect the choice of vector (N/C terminal tag vector).

***One clone ID might be correlated to multiple accession numbers, which share the same CDS sequence.

Reference Sequences (Refseq)

MRPL16 ( NM_017840.3 ) cDNA ORF clone, Homo sapiens(human) -> NP_060310.1 Homo sapiens mitochondrial ribosomal protein L16 (MRPL16), mRNA.

Price & Availability↑

CloneID	OHu09005
Clone ID Related Accession (Same CDS sequence)	NM_017840.3 , NM_017840.4
Accession Version	NM_017840.3	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 756bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2017-10-01
Organism	Homo sapiens(human)
Product	39S ribosomal protein L16, mitochondrial
Comment	Comment: REVIEWED REFSEQ: This record has been curated by NCBI staff. The reference sequence was derived from AA454132.1, AB049642.1 and CA428594.1. On Mar 5, 2008 this sequence version replaced NM_017840.2. ##Evidence-Data-START## Transcript exon combination :: AF183428.1, SRR1163657.189095.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA2142348 [ECO:0000348] ##Evidence-Data-END## ##RefSeq-Attributes-START## gene product(s) localized to mito. :: reported by MitoCarta ##RefSeq-Attributes-END## COMPLETENESS: complete on the 3' end.

ATGTGGAGGC TGCTGGCTCG CGCTAGTGCG CCGCTCCTGC GGGTGCCCTT GTCAGATTCC 
TGGGCACTCC TCCCCGCCAG TGCTGGCGTA AAGACACTGC TCCCAGTACC AAGTTTTGAA 
GATGTTTCCA TTCCTGAAAA ACCCAAGCTT AGATTTATTG AAAGGGCACC ACTTGTGCCA 
AAAGTAAGAA GAGAACCTAA AAATTTAAGT GACATACGGG GACCTTCCAC TGAAGCTACG 
GAGTTTACAG AAGGCAATTT TGCAATCTTG GCATTGGGTG GTGGCTACCT GCATTGGGGC 
CACTTTGAAA TGATGCGCCT GACAATCAAC CGCTCTATGG ACCCCAAGAA CATGTTTGCC 
ATATGGCGAG TACCAGCCCC TTTCAAGCCC ATCACTCGCA AAAGTGTTGG GCATCGCATG 
GGGGGAGGCA AAGGTGCTAT TGACCACTAC GTGACACCTG TGAAGGCTGG CCGCCTTGTT 
GTAGAGATGG GTGGGCGTTG TGAATTTGAA GAAGTGCAAG GTTTCCTTGA CCAGGTTGCC 
CACAAGTTGC CCTTCGCAGC AAAGGCTGTG AGCCGCGGGA CTCTAGAGAA GATGCGAAAA 
GATCAAGAGG AAAGAGAACG TAACAACCAG AACCCCTGGA CATTTGAGCG AATAGCCACT 
GCCAACATGC TGGGCATACG GAAAGTACTG AGCCCATATG ACTTGACCCA CAAGGGGAAA 
TACTGGGGCA AGTTCTACAT GCCCAAACGT GTGTAG

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_060310.1
CDS	215..970
Translation	MWRLLARASAPLLRVPLSDSWALLPASAGVKTLLPVPSFEDVSIPEKPKLRFIERAPLVPKVRREPKNLSDIRGPSTEATEFTEGNFAILALGGGYLHWGHFEMMRLTINRSMDPKNMFAIWRVPAPFKPITRKSVGHRMGGGKGAIDHYVTPVKAGRLVVEMGGRCEFEEVQGFLDQVAHKLPFAAKAVSRGTLEKMRKDQEERERNNQNPWTFERIATANMLGIRKVLSPYDLTHKGKYWGKFYMPKRV

Target ORF information:

RefSeq Version	NM_017840.3
Organism	Homo sapiens(human)
Definition	Homo sapiens mitochondrial ribosomal protein L16 (MRPL16), mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_017840.3

ORF Insert Sequence:

ATGTGGAGGC TGCTGGCTCG CGCTAGTGCG CCGCTCCTGC GGGTGCCCTT GTCAGATTCC 
TGGGCACTCC TCCCCGCCAG TGCTGGCGTA AAGACACTGC TCCCAGTACC AAGTTTTGAA 
GATGTTTCCA TTCCTGAAAA ACCCAAGCTT AGATTTATTG AAAGGGCACC ACTTGTGCCA 
AAAGTAAGAA GAGAACCTAA AAATTTAAGT GACATACGGG GACCTTCCAC TGAAGCTACG 
GAGTTTACAG AAGGCAATTT TGCAATCTTG GCATTGGGTG GTGGCTACCT GCATTGGGGC 
CACTTTGAAA TGATGCGCCT GACAATCAAC CGCTCTATGG ACCCCAAGAA CATGTTTGCC 
ATATGGCGAG TACCAGCCCC TTTCAAGCCC ATCACTCGCA AAAGTGTTGG GCATCGCATG 
GGGGGAGGCA AAGGTGCTAT TGACCACTAC GTGACACCTG TGAAGGCTGG CCGCCTTGTT 
GTAGAGATGG GTGGGCGTTG TGAATTTGAA GAAGTGCAAG GTTTCCTTGA CCAGGTTGCC 
CACAAGTTGC CCTTCGCAGC AAAGGCTGTG AGCCGCGGGA CTCTAGAGAA GATGCGAAAA 
GATCAAGAGG AAAGAGAACG TAACAACCAG AACCCCTGGA CATTTGAGCG AATAGCCACT 
GCCAACATGC TGGGCATACG GAAAGTACTG AGCCCATATG ACTTGACCCA CAAGGGGAAA 
TACTGGGGCA AGTTCTACAT GCCCAAACGT GTGTAG

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

MRPL16 ( NM_017840.4 ) cDNA ORF clone, Homo sapiens(human) -> NP_060310.1 Homo sapiens mitochondrial ribosomal protein L16 (MRPL16), mRNA.

Price & Availability↑

CloneID	OHu09005
Clone ID Related Accession (Same CDS sequence)	NM_017840.3 , NM_017840.4
Accession Version	NM_017840.4 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 756bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-09-25
Organism	Homo sapiens(human)
Product	39S ribosomal protein L16, mitochondrial
Comment	Comment: REVIEWED REFSEQ: This record has been curated by NCBI staff. The reference sequence was derived from AA454132.1 and AB049642.1. On Nov 22, 2018 this sequence version replaced NM_017840.3. ##Evidence-Data-START## Transcript exon combination :: AF183428.1, SRR5189667.360977.1 [ECO:0000332] RNAseq introns :: mixed/partial sample support SAMEA1965299, SAMEA1966682 [ECO:0000350] ##Evidence-Data-END## ##RefSeq-Attributes-START## gene product(s) localized to mito. :: reported by MitoCarta MANE Ensembl match :: ENST00000300151.5/ ENSP00000300151.4 RefSeq Select criteria :: based on single protein-coding transcript ##RefSeq-Attributes-END## COMPLETENESS: full length.

ATGTGGAGGC TGCTGGCTCG CGCTAGTGCG CCGCTCCTGC GGGTGCCCTT GTCAGATTCC 
TGGGCACTCC TCCCCGCCAG TGCTGGCGTA AAGACACTGC TCCCAGTACC AAGTTTTGAA 
GATGTTTCCA TTCCTGAAAA ACCCAAGCTT AGATTTATTG AAAGGGCACC ACTTGTGCCA 
AAAGTAAGAA GAGAACCTAA AAATTTAAGT GACATACGGG GACCTTCCAC TGAAGCTACG 
GAGTTTACAG AAGGCAATTT TGCAATCTTG GCATTGGGTG GTGGCTACCT GCATTGGGGC 
CACTTTGAAA TGATGCGCCT GACAATCAAC CGCTCTATGG ACCCCAAGAA CATGTTTGCC 
ATATGGCGAG TACCAGCCCC TTTCAAGCCC ATCACTCGCA AAAGTGTTGG GCATCGCATG 
GGGGGAGGCA AAGGTGCTAT TGACCACTAC GTGACACCTG TGAAGGCTGG CCGCCTTGTT 
GTAGAGATGG GTGGGCGTTG TGAATTTGAA GAAGTGCAAG GTTTCCTTGA CCAGGTTGCC 
CACAAGTTGC CCTTCGCAGC AAAGGCTGTG AGCCGCGGGA CTCTAGAGAA GATGCGAAAA 
GATCAAGAGG AAAGAGAACG TAACAACCAG AACCCCTGGA CATTTGAGCG AATAGCCACT 
GCCAACATGC TGGGCATACG GAAAGTACTG AGCCCATATG ACTTGACCCA CAAGGGGAAA 
TACTGGGGCA AGTTCTACAT GCCCAAACGT GTGTAG

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_060310.1
CDS	121..876
Translation	MWRLLARASAPLLRVPLSDSWALLPASAGVKTLLPVPSFEDVSIPEKPKLRFIERAPLVPKVRREPKNLSDIRGPSTEATEFTEGNFAILALGGGYLHWGHFEMMRLTINRSMDPKNMFAIWRVPAPFKPITRKSVGHRMGGGKGAIDHYVTPVKAGRLVVEMGGRCEFEEVQGFLDQVAHKLPFAAKAVSRGTLEKMRKDQEERERNNQNPWTFERIATANMLGIRKVLSPYDLTHKGKYWGKFYMPKRV

Target ORF information:

RefSeq Version	NM_017840.4
Organism	Homo sapiens(human)
Definition	Homo sapiens mitochondrial ribosomal protein L16 (MRPL16), mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_017840.4

ORF Insert Sequence:

ATGTGGAGGC TGCTGGCTCG CGCTAGTGCG CCGCTCCTGC GGGTGCCCTT GTCAGATTCC 
TGGGCACTCC TCCCCGCCAG TGCTGGCGTA AAGACACTGC TCCCAGTACC AAGTTTTGAA 
GATGTTTCCA TTCCTGAAAA ACCCAAGCTT AGATTTATTG AAAGGGCACC ACTTGTGCCA 
AAAGTAAGAA GAGAACCTAA AAATTTAAGT GACATACGGG GACCTTCCAC TGAAGCTACG 
GAGTTTACAG AAGGCAATTT TGCAATCTTG GCATTGGGTG GTGGCTACCT GCATTGGGGC 
CACTTTGAAA TGATGCGCCT GACAATCAAC CGCTCTATGG ACCCCAAGAA CATGTTTGCC 
ATATGGCGAG TACCAGCCCC TTTCAAGCCC ATCACTCGCA AAAGTGTTGG GCATCGCATG 
GGGGGAGGCA AAGGTGCTAT TGACCACTAC GTGACACCTG TGAAGGCTGG CCGCCTTGTT 
GTAGAGATGG GTGGGCGTTG TGAATTTGAA GAAGTGCAAG GTTTCCTTGA CCAGGTTGCC 
CACAAGTTGC CCTTCGCAGC AAAGGCTGTG AGCCGCGGGA CTCTAGAGAA GATGCGAAAA 
GATCAAGAGG AAAGAGAACG TAACAACCAG AACCCCTGGA CATTTGAGCG AATAGCCACT 
GCCAACATGC TGGGCATACG GAAAGTACTG AGCCCATATG ACTTGACCCA CAAGGGGAAA 
TACTGGGGCA AGTTCTACAT GCCCAAACGT GTGTAG

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

PubMed

Structures of the human mitochondrial ribosome in native states of assembly.
Nature structural & molecular biology24(10)866-869(2017 Oct)
Brown A,Rathore S,Kimanius D,Aibara S,Bai XC,Rorbach J,Amunts A,Ramakrishnan V

Variability of Gene Expression Identifies Transcriptional Regulators of Early Human Embryonic Development.
PLoS genetics11(8)e1005428(2015 Aug)
Hasegawa Y,Taylor D,Ovchinnikov DA,Wolvetang EJ,de Torrent? L,Mar JC

Structure of the large ribosomal subunit from human mitochondria.
Science (New York, N.Y.)346(6210)718-722(2014 Nov)
Brown A,Amunts A,Bai XC,Sugimoto Y,Edwards PC,Murshudov G,Scheres SHW,Ramakrishnan V

Genetic variants in nuclear-encoded mitochondrial genes influence AIDS progression.
PloS one5(9)e12862(2010 Sep)
Hendrickson SL,Lautenberger JA,Chinn LW,Malasky M,Sezgin E,Kingsley LA,Goedert JJ,Kirk GD,Gomperts ED,Buchbinder SP,Troyer JL,O'Brien SJ

Identification and characterization of over 100 mitochondrial ribosomal protein pseudogenes in the human genome.
Genomics81(5)468-80(2003 May)
Zhang Z,Gerstein M

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MRPL16 cDNA ORF clone, Homo sapiens(human)

Gene

Clones

gRNAs

Related articles in PubMed

Target ORF information:

Target ORF information:

ORF Insert Sequence:

Target ORF information:

Target ORF information:

ORF Insert Sequence:

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