PPIC cDNA ORF clone, Homo sapiens(human)

Gene
Clones
gRNAs

Summary

Gene Symbol	PPIC
Entrez Gene ID	5480
Full Name	peptidylprolyl isomerase C
Synonyms	CYPC
General protein information	Preferred Names peptidylprolyl isomerase C Names peptidyl-prolyl cis-trans isomerase C PPIase C cyclophilin C parvulin rotamase C
Gene Type	protein-coding
Organism	Homo sapiens(human)
Genome	Chromosome: 5 Map Location: 5q23.2
Summary	The protein encoded by this gene is a member of the peptidyl-prolyl cis-trans isomerase (PPIase)) family. PPIases catalyze the cis-trans isomerization of proline imidic peptide bonds in oligopeptides and accelerate the folding of proteins. Similar to other PPIases, this protein can bind immunosuppressant cyclosporin A. [provided by RefSeq, Jul 2008].
Disorder MIM:	123842

mRNA and Protein(s)

mRNA	Protein	Name
NM_000943.4	NP_000934.1	peptidyl-prolyl cis-trans isomerase C precursor
NM_000943.5	NP_000934.1	peptidyl-prolyl cis-trans isomerase C precursor

Pathways from BioSystems

Homologies

Pan troglodytes (chimpanzee)	PPIC	XP_003310839.1
Xenopus tropicalis (tropical clawed frog)	ppic	XP_002931773.2
Mus musculus (house mouse)	Ppic	NP_032934.1
Saccharomyces cerevisiae (baker's yeast)	CPR2	NP_011924.1
Homo sapiens (human)	PPIC	NP_000934.1
	PPIC	XP_001093271.1
Arabidopsis thaliana (thale cress)	ROC4	NP_001190159.1
Canis lupus familiaris (dog)	PPIC	XP_005626502.1
Bos taurus (cattle)	PPIC	NP_001070378.1
Rattus norvegicus (Norway rat)	Ppic	NP_001004215.1
Gallus gallus (chicken)	PPIC	XP_001231333.2
Danio rerio (zebrafish)	LOC100333141	XP_002667876.2

Gene Ontology
Bibliography

Related articles in PubMed

PPIC, EMP3 and CHI3L1 Are Novel Prognostic Markers for High Grade Glioma.
Gao YF, Zhu T, Mao CX, Liu ZX, Wang ZB, Mao XY, Li L, Yin JY, Zhou HH, Liu ZQ
International journal of molecular sciences17(11)(2016 Oct)

Cyclophilin C Participates in the US2-Mediated Degradation of Major Histocompatibility Complex Class I Molecules.
Chapman DC, Stocki P, Williams DB
PloS one10(12)e0145458(2015)

Depletion of cyclophilins B and C leads to dysregulation of endoplasmic reticulum redox homeostasis.
Stocki P, Chapman DC, Beach LA, Williams DB
The Journal of biological chemistry289(33)23086-96(2014 Aug)

Structural and biochemical characterization of the human cyclophilin family of peptidyl-prolyl isomerases.
Davis TL, Walker JR, Campagna-Slater V, Finerty PJ, Paramanathan R, Bernstein G, MacKenzie F, Tempel W, Ouyang H, Lee WH, Eisenmesser EZ, Dhe-Paganon S
PLoS biology8(7)e1000439(2010 Jul)

Genetic variants associated with cardiac structure and function: a meta-analysis and replication of genome-wide association data.
Vasan RS, Glazer NL, Felix JF, Lieb W, Wild PS, Felix SB, Watzinger N, Larson MG, Smith NL, Dehghan A, Grosshennig A, Schillert A, Teumer A, Schmidt R, Kathiresan S, Lumley T, Aulchenko YS, K?nig IR, Zeller T, Homuth G, Struchalin M, Aragam J, Bis JC, Rivadeneira F, Erdmann J, Schnabel RB, D?rr M, Zweiker R, Lind L, Rodeheffer RJ, Greiser KH, Levy D, Haritunians T, Deckers JW, Stritzke J, Lackner KJ, V?lker U, Ingelsson E, Kullo I, Haerting J, O'Donnell CJ, Heckbert SR, Stricker BH, Ziegler A, Reffelmann T, Redfield MM, Werdan K, Mitchell GF, Rice K, Arnett DK, Hofman A, Gottdiener JS, Uitterlinden AG, Meitinger T, Blettner M, Friedrich N, Wang TJ, Psaty BM, van Duijn CM, Wichmann HE, Munzel TF, Kroemer HK, Benjamin EJ, Rotter JI, Witteman JC, Schunkert H, Schmidt H, V?lzke H, Blankenberg S
JAMA302(2)168-78(2009 Jul)

GeneRIFs: Gene References Into Functions What's a GeneRIF?

Independent validation with glioma patients tissue (n = 70) and normal brain tissue (n = 19) found PPIC, EMP3 and CHI3L1 were up-regulated in glioma tissue. Survival value validation showed that the three genes correlated with patient survival by Kaplan-Meir analysis, including grades, age and therapy.
Title: PPIC, EMP3 and CHI3L1 Are Novel Prognostic Markers for High Grade Glioma.

Cyclophilin C participates in cytomegalovirus US2 protein-mediated degradation of major histocompatibility complex class I molecules.
Title: Cyclophilin C Participates in the US2-Mediated Degradation of Major Histocompatibility Complex Class I Molecules.

These findings establish cyclophilin C as an ER cyclophilin, demonstrate the novel involvement of cyclophilins B and C in ER redox homeostasis
Title: Depletion of cyclophilins B and C leads to dysregulation of endoplasmic reticulum redox homeostasis.

The following PPIC gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the PPIC cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1⁺/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.

***CloneID	Accession No.	Definition	**Vector	*Turnaround time	Price (USD)
OHu02712	NM_000943.5 Latest version!	Homo sapiens peptidylprolyl isomerase C (PPIC), mRNA.	pcDNA3.1-C-(k)DYK or customized vector	in pcDNA3.1-C-(k)DYK	$49.50-$69.30 $99.00
View Old Accession Versions >>
OHu02712	NM_000943.4	Homo sapiens peptidylprolyl isomerase C (PPIC), mRNA.	pcDNA3.1-C-(k)DYK or customized vector	in pcDNA3.1-C-(k)DYK	$49.50-$69.30 $99.00
Hide Old Accession Versions >>

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** GenScript guarantees 100% sequence accuracy of all synthetic DNA constructs we deliver, but we do not guarantee protein expression in your experimental system. Protein expression is influenced by many factors that may vary between experiments or laboratories. In addition, please pay attention to the signal peptide, propeptide and transit peptide in target ORF, which may affect the choice of vector (N/C terminal tag vector).

***One clone ID might be correlated to multiple accession numbers, which share the same CDS sequence.

Reference Sequences (Refseq)

PPIC ( NM_000943.4 ) cDNA ORF clone, Homo sapiens(human) -> NP_000934.1 Homo sapiens peptidylprolyl isomerase C (PPIC), mRNA.

Price & Availability↑

CloneID	OHu02712
Clone ID Related Accession (Same CDS sequence)	NM_000943.4 , NM_000943.5
Accession Version	NM_000943.4	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 639bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2018-06-22
Organism	Homo sapiens(human)
Product	peptidyl-prolyl cis-trans isomerase C precursor
Comment	Comment: REVIEWED REFSEQ: This record has been curated by NCBI staff. The reference sequence was derived from BG721394.1, CB963241.1, BU075157.1 and BX472017.1. On Mar 15, 2004 this sequence version replaced NM_000943.3. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: ERR279869.1702.1, SRR1660807.257740.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA2153307 [ECO:0000348] ##Evidence-Data-END## COMPLETENESS: complete on the 3' end.

ATGGGCCCGG GTCCTCGGCT GCTGCTACCT CTCGTGCTTT GCGTGGGGCT CGGCGCACTT 
GTGTTTTCTT CGGGGGCCGA GGGCTTCCGC AAGCGAGGCC CCTCGGTGAC GGCCAAGGTC 
TTCTTTGATG TGAGGATTGG AGACAAAGAT GTTGGCAGAA TTGTGATTGG CCTCTTTGGA 
AAAGTTGTGC CCAAGACAGT GGAAAATTTT GTTGCTCTAG CAACAGGAGA GAAAGGATAT 
GGATATAAAG GAAGCAAGTT TCATCGTGTC ATCAAGGATT TCATGATTCA AGGAGGTGAC 
ATCACCACTG GAGATGGCAC TGGGGGTGTG AGCATCTATG GTGAGACATT TCCAGATGAG 
AACTTCAAGC TGAAGCACTA TGGCATTGGG TGGGTCAGCA TGGCCAACGC TGGGCCTGAC 
ACCAATGGCT CTCAGTTCTT TATCACCTTG ACCAAGCCCA CCTGGTTGGA CGGCAAACAT 
GTGGTGTTTG GAAAAGTCAT TGATGGGATG ACAGTGGTGC ACTCCATAGA GCTCCAAGCA 
ACTGATGGGC ATGACCGTCC ACTCACCAAC TGCTCGATCA TCAACAGTGG CAAGATAGAC 
GTGAAAACGC CTTTTGTGGT TGAGATCGCT GATTGGTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_000934.1
CDS	106..744
Translation	MGPGPRLLLPLVLCVGLGALVFSSGAEGFRKRGPSVTAKVFFDVRIGDKDVGRIVIGLFGKVVPKTVENFVALATGEKGYGYKGSKFHRVIKDFMIQGGDITTGDGTGGVSIYGETFPDENFKLKHYGIGWVSMANAGPDTNGSQFFITLTKPTWLDGKHVVFGKVIDGMTVVHSIELQATDGHDRPLTNCSIINSGKIDVKTPFVVEIADW

Target ORF information:

RefSeq Version	NM_000943.4
Organism	Homo sapiens(human)
Definition	Homo sapiens peptidylprolyl isomerase C (PPIC), mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_000943.4

ORF Insert Sequence:

ATGGGCCCGG GTCCTCGGCT GCTGCTACCT CTCGTGCTTT GCGTGGGGCT CGGCGCACTT 
GTGTTTTCTT CGGGGGCCGA GGGCTTCCGC AAGCGAGGCC CCTCGGTGAC GGCCAAGGTC 
TTCTTTGATG TGAGGATTGG AGACAAAGAT GTTGGCAGAA TTGTGATTGG CCTCTTTGGA 
AAAGTTGTGC CCAAGACAGT GGAAAATTTT GTTGCTCTAG CAACAGGAGA GAAAGGATAT 
GGATATAAAG GAAGCAAGTT TCATCGTGTC ATCAAGGATT TCATGATTCA AGGAGGTGAC 
ATCACCACTG GAGATGGCAC TGGGGGTGTG AGCATCTATG GTGAGACATT TCCAGATGAG 
AACTTCAAGC TGAAGCACTA TGGCATTGGG TGGGTCAGCA TGGCCAACGC TGGGCCTGAC 
ACCAATGGCT CTCAGTTCTT TATCACCTTG ACCAAGCCCA CCTGGTTGGA CGGCAAACAT 
GTGGTGTTTG GAAAAGTCAT TGATGGGATG ACAGTGGTGC ACTCCATAGA GCTCCAAGCA 
ACTGATGGGC ATGACCGTCC ACTCACCAAC TGCTCGATCA TCAACAGTGG CAAGATAGAC 
GTGAAAACGC CTTTTGTGGT TGAGATCGCT GATTGGTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

PPIC ( NM_000943.5 ) cDNA ORF clone, Homo sapiens(human) -> NP_000934.1 Homo sapiens peptidylprolyl isomerase C (PPIC), mRNA.

Price & Availability↑

CloneID	OHu02712
Clone ID Related Accession (Same CDS sequence)	NM_000943.4 , NM_000943.5
Accession Version	NM_000943.5 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 639bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-10-20
Organism	Homo sapiens(human)
Product	peptidyl-prolyl cis-trans isomerase C precursor
Comment	Comment: REVIEWED REFSEQ: This record has been curated by NCBI staff. The reference sequence was derived from CB963241.1, BG721394.1, BU075157.1, BX472017.1 and AC022116.5. On May 17, 2019 this sequence version replaced NM_000943.4. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: AK290321.1, SRR5189655.21337.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA2153307 [ECO:0000348] ##Evidence-Data-END## ##RefSeq-Attributes-START## MANE Ensembl match :: ENST00000306442.5/ ENSP00000303057.4 RefSeq Select criteria :: based on single protein-coding transcript ##RefSeq-Attributes-END## COMPLETENESS: complete on the 3' end.

ATGGGCCCGG GTCCTCGGCT GCTGCTACCT CTCGTGCTTT GCGTGGGGCT CGGCGCACTT 
GTGTTTTCTT CGGGGGCCGA GGGCTTCCGC AAGCGAGGCC CCTCGGTGAC GGCCAAGGTC 
TTCTTTGATG TGAGGATTGG AGACAAAGAT GTTGGCAGAA TTGTGATTGG CCTCTTTGGA 
AAAGTTGTGC CCAAGACAGT GGAAAATTTT GTTGCTCTAG CAACAGGAGA GAAAGGATAT 
GGATATAAAG GAAGCAAGTT TCATCGTGTC ATCAAGGATT TCATGATTCA AGGAGGTGAC 
ATCACCACTG GAGATGGCAC TGGGGGTGTG AGCATCTATG GTGAGACATT TCCAGATGAG 
AACTTCAAGC TGAAGCACTA TGGCATTGGG TGGGTCAGCA TGGCCAACGC TGGGCCTGAC 
ACCAATGGCT CTCAGTTCTT TATCACCTTG ACCAAGCCCA CCTGGTTGGA CGGCAAACAT 
GTGGTGTTTG GAAAAGTCAT TGATGGGATG ACAGTGGTGC ACTCCATAGA GCTCCAAGCA 
ACTGATGGGC ATGACCGTCC ACTCACCAAC TGCTCGATCA TCAACAGTGG CAAGATAGAC 
GTGAAAACGC CTTTTGTGGT TGAGATCGCT GATTGGTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_000934.1
CDS	101..739
Translation	MGPGPRLLLPLVLCVGLGALVFSSGAEGFRKRGPSVTAKVFFDVRIGDKDVGRIVIGLFGKVVPKTVENFVALATGEKGYGYKGSKFHRVIKDFMIQGGDITTGDGTGGVSIYGETFPDENFKLKHYGIGWVSMANAGPDTNGSQFFITLTKPTWLDGKHVVFGKVIDGMTVVHSIELQATDGHDRPLTNCSIINSGKIDVKTPFVVEIADW

Target ORF information:

RefSeq Version	NM_000943.5
Organism	Homo sapiens(human)
Definition	Homo sapiens peptidylprolyl isomerase C (PPIC), mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_000943.5

ORF Insert Sequence:

ATGGGCCCGG GTCCTCGGCT GCTGCTACCT CTCGTGCTTT GCGTGGGGCT CGGCGCACTT 
GTGTTTTCTT CGGGGGCCGA GGGCTTCCGC AAGCGAGGCC CCTCGGTGAC GGCCAAGGTC 
TTCTTTGATG TGAGGATTGG AGACAAAGAT GTTGGCAGAA TTGTGATTGG CCTCTTTGGA 
AAAGTTGTGC CCAAGACAGT GGAAAATTTT GTTGCTCTAG CAACAGGAGA GAAAGGATAT 
GGATATAAAG GAAGCAAGTT TCATCGTGTC ATCAAGGATT TCATGATTCA AGGAGGTGAC 
ATCACCACTG GAGATGGCAC TGGGGGTGTG AGCATCTATG GTGAGACATT TCCAGATGAG 
AACTTCAAGC TGAAGCACTA TGGCATTGGG TGGGTCAGCA TGGCCAACGC TGGGCCTGAC 
ACCAATGGCT CTCAGTTCTT TATCACCTTG ACCAAGCCCA CCTGGTTGGA CGGCAAACAT 
GTGGTGTTTG GAAAAGTCAT TGATGGGATG ACAGTGGTGC ACTCCATAGA GCTCCAAGCA 
ACTGATGGGC ATGACCGTCC ACTCACCAAC TGCTCGATCA TCAACAGTGG CAAGATAGAC 
GTGAAAACGC CTTTTGTGGT TGAGATCGCT GATTGGTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

PubMed

PPIC, EMP3 and CHI3L1 Are Novel Prognostic Markers for High Grade Glioma.
International journal of molecular sciences17(11)(2016 Oct)
Gao YF,Zhu T,Mao CX,Liu ZX,Wang ZB,Mao XY,Li L,Yin JY,Zhou HH,Liu ZQ

Cyclophilin C Participates in the US2-Mediated Degradation of Major Histocompatibility Complex Class I Molecules.
PloS one10(12)e0145458(2015)
Chapman DC,Stocki P,Williams DB

Depletion of cyclophilins B and C leads to dysregulation of endoplasmic reticulum redox homeostasis.
The Journal of biological chemistry289(33)23086-96(2014 Aug)
Stocki P,Chapman DC,Beach LA,Williams DB

Structural and biochemical characterization of the human cyclophilin family of peptidyl-prolyl isomerases.
PLoS biology8(7)e1000439(2010 Jul)
Davis TL,Walker JR,Campagna-Slater V,Finerty PJ,Paramanathan R,Bernstein G,MacKenzie F,Tempel W,Ouyang H,Lee WH,Eisenmesser EZ,Dhe-Paganon S

Genetic variants associated with cardiac structure and function: a meta-analysis and replication of genome-wide association data.
JAMA302(2)168-78(2009 Jul)
Vasan RS,Glazer NL,Felix JF,Lieb W,Wild PS,Felix SB,Watzinger N,Larson MG,Smith NL,Dehghan A,Grosshennig A,Schillert A,Teumer A,Schmidt R,Kathiresan S,Lumley T,Aulchenko YS,K?nig IR,Zeller T,Homuth G,Struchalin M,Aragam J,Bis JC,Rivadeneira F,Erdmann J,Schnabel RB,D?rr M,Zweiker R,Lind L,Rodeheffer RJ,Greiser KH,Levy D,Haritunians T,Deckers JW,Stritzke J,Lackner KJ,V?lker U,Ingelsson E,Kullo I,Haerting J,O'Donnell CJ,Heckbert SR,Stricker BH,Ziegler A,Reffelmann T,Redfield MM,Werdan K,Mitchell GF,Rice K,Arnett DK,Hofman A,Gottdiener JS,Uitterlinden AG,Meitinger T,Blettner M,Friedrich N,Wang TJ,Psaty BM,van Duijn CM,Wichmann HE,Munzel TF,Kroemer HK,Benjamin EJ,Rotter JI,Witteman JC,Schunkert H,Schmidt H,V?lzke H,Blankenberg S

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PPIC cDNA ORF clone, Homo sapiens(human)

Gene

Clones

gRNAs

Related articles in PubMed

Target ORF information:

Target ORF information:

ORF Insert Sequence:

Target ORF information:

Target ORF information:

ORF Insert Sequence:

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