CTSA cDNA ORF clone, Homo sapiens(human)

Gene
Clones
gRNAs

Summary

Gene Symbol	CTSA
Entrez Gene ID	5476
Full Name	cathepsin A
Synonyms	GLB2,GSL,NGBE,PPCA,PPGB
General protein information	Preferred Names cathepsin A Names lysosomal protective protein beta-galactosidase 2 beta-galactosidase protective protein carboxypeptidase C carboxypeptidase Y-like kininase carboxypeptidase-L deamidase lysosomal carboxypeptidase A protective protein cathepsin A urinary kininase
Gene Type	protein-coding
Organism	Homo sapiens(human)
Genome	Chromosome: 20 Map Location: 20q13.12
Summary	This gene encodes a member of the peptidase S10 family of serine carboxypeptidases. Alternative splicing results in multiple transcript variants, at least one of which encodes a preproprotein that is proteolytically processed to generate two chains that comprise the heterodimeric active enzyme. This enzyme possesses deamidase, esterase and carboxypeptidase activities and acts as a scaffold in the lysosomal multienzyme complex. Mutations in this gene are associated with galactosialidosis. [provided by RefSeq, Nov 2015].
Disorder MIM:	613111
Disorder Html:	Galactosialidosis, 256540 (3)

mRNA and Protein(s)

mRNA	Protein	Name
NM_000308.2	NP_000299.2	lysosomal protective protein isoform a precursor
NM_001167594.2	NP_001161066.1	lysosomal protective protein isoform c precursor
NM_000308.4	NP_000299.3	lysosomal protective protein isoform a precursor
NM_000308.3	NP_000299.2	lysosomal protective protein isoform a precursor
NM_001127695.1	NP_001121167.1	lysosomal protective protein isoform b precursor
NM_001127695.2	NP_001121167.1	lysosomal protective protein isoform b preproprotein

Pathways from BioSystems

Homologies

Homo sapiens (human)	CTSA	NP_000299.2
	CTSA	XP_001106032.1
Caenorhabditis elegans (roundworm)	F41C3.5	NP_494846.1
Kluyveromyces lactis	KLLA0A09977g	XP_451436.1
Danio rerio (zebrafish)	ctsa	NP_956844.1
Arabidopsis thaliana (thale cress)	scpl21	NP_189169.1
Gallus gallus (chicken)	CTSA	NP_001026662.1
Schizosaccharomyces pombe (fission yeast)	cpy1	NP_594425.1
Oryza sativa (rice)	Os04g0321700	NP_001052464.1
Oryza sativa (rice)	Os12g0257000	NP_001066510.1
Xenopus tropicalis (tropical clawed frog)	ctsa	NP_001039207.1
Bos taurus (cattle)	CTSA	NP_001030403.1
Mus musculus (house mouse)	Ctsa	NP_032932.2
Arabidopsis thaliana (thale cress)	scpl20	NP_193027.5
Pan troglodytes (chimpanzee)	CTSA	XP_001159669.2
Canis lupus familiaris (dog)	CTSA	NP_001103385.1
Rattus norvegicus (Norway rat)	Ctsa	NP_001011959.1
Caenorhabditis elegans (roundworm)	F13D12.6	NP_496507.1
Saccharomyces cerevisiae (baker's yeast)	PRC1	NP_014026.1
Eremothecium gossypii	AGOS_AGL328C	NP_986339.1
Magnaporthe oryzae (rice blast fungus)	MGG_05663	XP_003710561.1
Neurospora crassa	NCU00477	XP_956796.1

Gene Ontology
Bibliography

Related articles in PubMed

Altered mitochondrial expression genes in patients receiving right ventricular apical pacing.
Xu H, Gao J, Wang F
Experimental and molecular pathology100(3)469-75(2016 06)

Lysosomal multienzyme complex: pros and cons of working together.
Bonten EJ, Annunziata I, d'Azzo A
Cellular and molecular life sciences : CMLS71(11)2017-32(2014 Jun)

GeneRIFs: Gene References Into Functions What's a GeneRIF?

The gene signature of OPA1, CTSA, NDUFA1, STK10 and PRDX1 was able to identify patients post-implant with a sensitivity of 91% and a specificity of 86% in discrimination between post-implant group and healthy controls.
Title: Altered mitochondrial expression genes in patients receiving right ventricular apical pacing.

Galactosialidosis is a rare lysosomal storage disease caused by a combined deficiency of GM1 beta-galactosidase (beta-gal) and neuraminidase secondary to a defect of a lysosomal enzyme protective protein/cathepsin A (PPCA) and mutation in CTSA gene.
Title: Chemical chaperone treatment for galactosialidosis: Effect of NOEV on ?-galactosidase activities in fibroblasts.

Case Report: galactosialidosis with novel mutations of CTSA gene diagnosed using placental pathology.
Title: A case of galactosialidosis with novel mutations of the protective protein/cathepsin a gene: diagnosis prompted by trophoblast vacuolization on placental examination.

We identified compound heterozygous mutations in the CTSA gene, responsible for causing galactosialidosis
Title: Clinical utility of whole-exome sequencing in rare diseases: Galactosialidosis.

correct nomenclature of mutations for this gene is discussed; clinical and mutational analyses of 4 cases with rare infantile form of galactosialidosis; identified 3 novel nucleotide changes, 2 resulting in missense mutations and the third, resulting in the p.Gln406* stop codon; complexity of the clinical phenotypes in GS reflects dual functions of PPCA/CTSA
Title: Galactosialidosis: review and analysis of CTSA gene mutations.

The following CTSA gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the CTSA cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1⁺/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.

***CloneID	Accession No.	Definition	**Vector	*Turnaround time	Price (USD)
OHu17877	NM_000308.3 Latest version!	Homo sapiens cathepsin A (CTSA), transcript variant 1, mRNA.	pcDNA3.1-C-(k)DYK or customized vector	in pcDNA3.1-C-(k)DYK	$209.50-$293.30 $419.00
OHu04054	NM_001167594.2 Latest version!	Homo sapiens cathepsin A (CTSA), transcript variant 3, mRNA.	pcDNA3.1-C-(k)DYK or customized vector	7-9	$223.30 $319.00
OHu06757	NM_001127695.2 Latest version!	Homo sapiens cathepsin A (CTSA), transcript variant 2, mRNA.	pcDNA3.1-C-(k)DYK or customized vector	7-9	$223.30 $319.00
OHu06757	NM_000308.4 Latest version!	Homo sapiens cathepsin A (CTSA), transcript variant 1, mRNA.	pcDNA3.1-C-(k)DYK or customized vector	9-11	$223.30 $319.00
View Old Accession Versions >>
OHu17877	NM_000308.2	Homo sapiens cathepsin A (CTSA), transcript variant 1, mRNA.	pcDNA3.1-C-(k)DYK or customized vector	in pcDNA3.1-C-(k)DYK	$209.50-$293.30 $419.00
OHu06757	NM_001127695.1	Homo sapiens cathepsin A (CTSA), transcript variant 2, mRNA.	pcDNA3.1-C-(k)DYK or customized vector	7-9	$223.30 $319.00
Hide Old Accession Versions >>

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***One clone ID might be correlated to multiple accession numbers, which share the same CDS sequence.

Reference Sequences (Refseq)

CTSA ( NM_000308.2 ) cDNA ORF clone, Homo sapiens(human) -> NP_000299.2 Homo sapiens cathepsin A (CTSA), transcript variant 1, mRNA.

Price & Availability↑

CloneID	OHu17877
Clone ID Related Accession (Same CDS sequence)	NM_000308.2 , NM_000308.3
Accession Version	NM_000308.2	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 1497bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2015-03-14
Organism	Homo sapiens(Human)
Product	lysosomal protective protein isoform a precursor
Comment

ATGACTTCCA GTCCCCGGGC GCCTCCTGGA GAGCAAGGAC GCGGGGGAGC AGAGATGATC 
CGAGCCGCGC CGCCGCCGCT GTTCCTGCTG CTGCTGCTGC TGCTGCTGCT AGTGTCCTGG 
GCGTCCCGAG GCGAGGCAGC CCCCGACCAG GACGAGATCC AGCGCCTCCC CGGGCTGGCC 
AAGCAGCCGT CTTTCCGCCA GTACTCCGGC TACCTCAAAG GCTCCGGCTC CAAGCACCTC 
CACTACTGGT TTGTGGAGTC CCAGAAGGAT CCCGAGAACA GCCCTGTGGT GCTTTGGCTC 
AATGGGGGTC CCGGCTGCAG CTCACTAGAT GGGCTCCTCA CAGAGCATGG CCCCTTCCTG 
GTCCAGCCAG ATGGTGTCAC CCTGGAGTAC AACCCCTATT CTTGGAATCT GATTGCCAAT 
GTGTTATACC TGGAGTCCCC AGCTGGGGTG GGCTTCTCCT ACTCCGATGA CAAGTTTTAT 
GCAACTAATG ACACTGAGGT CGCCCAGAGC AATTTTGAGG CCCTTCAAGA TTTCTTCCGC 
CTCTTTCCGG AGTACAAGAA CAACAAACTT TTCCTGACCG GGGAGAGCTA TGCTGGCATC 
TACATCCCCA CCCTGGCCGT GCTGGTCATG CAGGATCCCA GCATGAACCT TCAGGGGCTG 
GCTGTGGGCA ATGGACTCTC CTCCTATGAG CAGAATGACA ACTCCCTGGT CTACTTTGCC 
TACTACCATG GCCTTCTGGG GAACAGGCTT TGGTCTTCTC TCCAGACCCA CTGCTGCTCT 
CAAAACAAGT GTAACTTCTA TGACAACAAA GACCTGGAAT GCGTGACCAA TCTTCAGGAA 
GTGGCCCGCA TCGTGGGCAA CTCTGGCCTC AACATCTACA ATCTCTATGC CCCGTGTGCT 
GGAGGGGTGC CCAGCCATTT TAGGTATGAG AAGGACACTG TTGTGGTCCA GGATTTGGGC 
AACATCTTCA CTCGCCTGCC ACTCAAGCGG ATGTGGCATC AGGCACTGCT GCGCTCAGGG 
GATAAAGTGC GCATGGACCC CCCCTGCACC AACACAACAG CTGCTTCCAC CTACCTCAAC 
AACCCGTACG TGCGGAAGGC CCTCAACATC CCGGAGCAGC TGCCACAATG GGACATGTGC 
AACTTTCTGG TAAACTTACA GTACCGCCGT CTCTACCGAA GCATGAACTC CCAGTATCTG 
AAGCTGCTTA GCTCACAGAA ATACCAGATC CTATTATATA ATGGAGATGT AGACATGGCC 
TGCAATTTCA TGGGGGATGA GTGGTTTGTG GATTCCCTCA ACCAGAAGAT GGAGGTGCAG 
CGCCGGCCCT GGTTAGTGAA GTACGGGGAC AGCGGGGAGC AGATTGCCGG CTTCGTGAAG 
GAGTTCTCCC ACATCGCCTT TCTCACGATC AAGGGCGCCG GCCACATGGT TCCCACCGAC 
AAGCCCCTCG CTGCCTTCAC CATGTTCTCC CGCTTCCTGA ACAAGCAGCC ATACTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq

NP_000299.2

Translation

MTSSPRAPPGEQGRGGAEMIRAAPPPLFLLLLLLLLLVSWASRGEAAPDQDEIQRLPGLAKQPSFRQYSGYLKGSGSKHLHYWFVESQKDPENSPVVLWLNGGPGCSSLDGLLTEHGPFLVQPDGVTLEYNPYSWNLIANVLYLESPAGVGFSYSDDKFYATNDTEVAQSNFEALQDFFRLFPEYKNNKLFLTGESYAGIYIPTLAVLVMQDPSMNLQGLAVGNGLSSYEQNDNSLVYFAYYHGLLGNRLWSSLQTHCCSQNKCNFYDNKDLECVTNLQEVARIVGNSGLNIYNLYAPCAGGVPSHFRYEKDTVVVQDLGNIFTRLPLKRMWHQALLRSGDKVRMDPPCTNTTAASTYLNNPYVRKALNIPEQLPQWDMCNFLVNLQYRRLYRSMNSQYLKLLSSQKYQILLYNGDVDMACNFMGDEWFVDSLNQKMEVQRRPWLVKYGDSGEQIAGFVKEFSHIAFLTIKGAGHMVPTDKPLAAFTMFSRFLNKQPY

Target ORF information:

RefSeq Version	NM_000308.2
Organism	Homo sapiens(Human)
Definition	Homo sapiens cathepsin A (CTSA), transcript variant 1, mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_000308.2

ORF Insert Sequence:

ATGACTTCCA GTCCCCGGGC GCCTCCTGGA GAGCAAGGAC GCGGGGGAGC AGAGATGATC 
CGAGCCGCGC CGCCGCCGCT GTTCCTGCTG CTGCTGCTGC TGCTGCTGCT AGTGTCCTGG 
GCGTCCCGAG GCGAGGCAGC CCCCGACCAG GACGAGATCC AGCGCCTCCC CGGGCTGGCC 
AAGCAGCCGT CTTTCCGCCA GTACTCCGGC TACCTCAAAG GCTCCGGCTC CAAGCACCTC 
CACTACTGGT TTGTGGAGTC CCAGAAGGAT CCCGAGAACA GCCCTGTGGT GCTTTGGCTC 
AATGGGGGTC CCGGCTGCAG CTCACTAGAT GGGCTCCTCA CAGAGCATGG CCCCTTCCTG 
GTCCAGCCAG ATGGTGTCAC CCTGGAGTAC AACCCCTATT CTTGGAATCT GATTGCCAAT 
GTGTTATACC TGGAGTCCCC AGCTGGGGTG GGCTTCTCCT ACTCCGATGA CAAGTTTTAT 
GCAACTAATG ACACTGAGGT CGCCCAGAGC AATTTTGAGG CCCTTCAAGA TTTCTTCCGC 
CTCTTTCCGG AGTACAAGAA CAACAAACTT TTCCTGACCG GGGAGAGCTA TGCTGGCATC 
TACATCCCCA CCCTGGCCGT GCTGGTCATG CAGGATCCCA GCATGAACCT TCAGGGGCTG 
GCTGTGGGCA ATGGACTCTC CTCCTATGAG CAGAATGACA ACTCCCTGGT CTACTTTGCC 
TACTACCATG GCCTTCTGGG GAACAGGCTT TGGTCTTCTC TCCAGACCCA CTGCTGCTCT 
CAAAACAAGT GTAACTTCTA TGACAACAAA GACCTGGAAT GCGTGACCAA TCTTCAGGAA 
GTGGCCCGCA TCGTGGGCAA CTCTGGCCTC AACATCTACA ATCTCTATGC CCCGTGTGCT 
GGAGGGGTGC CCAGCCATTT TAGGTATGAG AAGGACACTG TTGTGGTCCA GGATTTGGGC 
AACATCTTCA CTCGCCTGCC ACTCAAGCGG ATGTGGCATC AGGCACTGCT GCGCTCAGGG 
GATAAAGTGC GCATGGACCC CCCCTGCACC AACACAACAG CTGCTTCCAC CTACCTCAAC 
AACCCGTACG TGCGGAAGGC CCTCAACATC CCGGAGCAGC TGCCACAATG GGACATGTGC 
AACTTTCTGG TAAACTTACA GTACCGCCGT CTCTACCGAA GCATGAACTC CCAGTATCTG 
AAGCTGCTTA GCTCACAGAA ATACCAGATC CTATTATATA ATGGAGATGT AGACATGGCC 
TGCAATTTCA TGGGGGATGA GTGGTTTGTG GATTCCCTCA ACCAGAAGAT GGAGGTGCAG 
CGCCGGCCCT GGTTAGTGAA GTACGGGGAC AGCGGGGAGC AGATTGCCGG CTTCGTGAAG 
GAGTTCTCCC ACATCGCCTT TCTCACGATC AAGGGCGCCG GCCACATGGT TCCCACCGAC 
AAGCCCCTCG CTGCCTTCAC CATGTTCTCC CGCTTCCTGA ACAAGCAGCC ATACTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

CTSA ( NM_000308.3 ) cDNA ORF clone, Homo sapiens(human) -> NP_000299.2 Homo sapiens cathepsin A (CTSA), transcript variant 1, mRNA.

Price & Availability↑

CloneID	OHu17877
Clone ID Related Accession (Same CDS sequence)	NM_000308.2 , NM_000308.3
Accession Version	NM_000308.3 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 1497bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-06-03
Organism	Homo sapiens(human)
Product	lysosomal protective protein isoform a precursor
Comment	Comment: REVIEWED REFSEQ: This record has been curated by NCBI staff. The reference sequence was derived from AK172808.1, AL008726.3, DA029446.1 and BC093009.1. This sequence is a reference standard in the RefSeqGene project. On Nov 13, 2015 this sequence version replaced NM_000308.2. Transcript Variant: This variant (1) encodes the longest isoform (a). This isoform (a) may undergo proteolytic processing similar to isoform (b). Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: BC093009.1, SRR1803612.21877.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA1965299, SAMEA1966682 [ECO:0000348] ##Evidence-Data-END## ##RefSeq-Attributes-START## RefSeq Select criteria :: based on manual assertion, conservation, expression, longest protein ##RefSeq-Attributes-END## COMPLETENESS: complete on the 3' end.

ATGACTTCCA GTCCCCGGGC GCCTCCTGGA GAGCAAGGAC GCGGGGGAGC AGAGATGATC 
CGAGCCGCGC CGCCGCCGCT GTTCCTGCTG CTGCTGCTGC TGCTGCTGCT AGTGTCCTGG 
GCGTCCCGAG GCGAGGCAGC CCCCGACCAG GACGAGATCC AGCGCCTCCC CGGGCTGGCC 
AAGCAGCCGT CTTTCCGCCA GTACTCCGGC TACCTCAAAG GCTCCGGCTC CAAGCACCTC 
CACTACTGGT TTGTGGAGTC CCAGAAGGAT CCCGAGAACA GCCCTGTGGT GCTTTGGCTC 
AATGGGGGTC CCGGCTGCAG CTCACTAGAT GGGCTCCTCA CAGAGCATGG CCCCTTCCTG 
GTCCAGCCAG ATGGTGTCAC CCTGGAGTAC AACCCCTATT CTTGGAATCT GATTGCCAAT 
GTGTTATACC TGGAGTCCCC AGCTGGGGTG GGCTTCTCCT ACTCCGATGA CAAGTTTTAT 
GCAACTAATG ACACTGAGGT CGCCCAGAGC AATTTTGAGG CCCTTCAAGA TTTCTTCCGC 
CTCTTTCCGG AGTACAAGAA CAACAAACTT TTCCTGACCG GGGAGAGCTA TGCTGGCATC 
TACATCCCCA CCCTGGCCGT GCTGGTCATG CAGGATCCCA GCATGAACCT TCAGGGGCTG 
GCTGTGGGCA ATGGACTCTC CTCCTATGAG CAGAATGACA ACTCCCTGGT CTACTTTGCC 
TACTACCATG GCCTTCTGGG GAACAGGCTT TGGTCTTCTC TCCAGACCCA CTGCTGCTCT 
CAAAACAAGT GTAACTTCTA TGACAACAAA GACCTGGAAT GCGTGACCAA TCTTCAGGAA 
GTGGCCCGCA TCGTGGGCAA CTCTGGCCTC AACATCTACA ATCTCTATGC CCCGTGTGCT 
GGAGGGGTGC CCAGCCATTT TAGGTATGAG AAGGACACTG TTGTGGTCCA GGATTTGGGC 
AACATCTTCA CTCGCCTGCC ACTCAAGCGG ATGTGGCATC AGGCACTGCT GCGCTCAGGG 
GATAAAGTGC GCATGGACCC CCCCTGCACC AACACAACAG CTGCTTCCAC CTACCTCAAC 
AACCCGTACG TGCGGAAGGC CCTCAACATC CCGGAGCAGC TGCCACAATG GGACATGTGC 
AACTTTCTGG TAAACTTACA GTACCGCCGT CTCTACCGAA GCATGAACTC CCAGTATCTG 
AAGCTGCTTA GCTCACAGAA ATACCAGATC CTATTATATA ATGGAGATGT AGACATGGCC 
TGCAATTTCA TGGGGGATGA GTGGTTTGTG GATTCCCTCA ACCAGAAGAT GGAGGTGCAG 
CGCCGGCCCT GGTTAGTGAA GTACGGGGAC AGCGGGGAGC AGATTGCCGG CTTCGTGAAG 
GAGTTCTCCC ACATCGCCTT TCTCACGATC AAGGGCGCCG GCCACATGGT TCCCACCGAC 
AAGCCCCTCG CTGCCTTCAC CATGTTCTCC CGCTTCCTGA ACAAGCAGCC ATACTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_000299.2
CDS	1183..2679
Translation	MTSSPRAPPGEQGRGGAEMIRAAPPPLFLLLLLLLLLVSWASRGEAAPDQDEIQRLPGLAKQPSFRQYSGYLKGSGSKHLHYWFVESQKDPENSPVVLWLNGGPGCSSLDGLLTEHGPFLVQPDGVTLEYNPYSWNLIANVLYLESPAGVGFSYSDDKFYATNDTEVAQSNFEALQDFFRLFPEYKNNKLFLTGESYAGIYIPTLAVLVMQDPSMNLQGLAVGNGLSSYEQNDNSLVYFAYYHGLLGNRLWSSLQTHCCSQNKCNFYDNKDLECVTNLQEVARIVGNSGLNIYNLYAPCAGGVPSHFRYEKDTVVVQDLGNIFTRLPLKRMWHQALLRSGDKVRMDPPCTNTTAASTYLNNPYVRKALNIPEQLPQWDMCNFLVNLQYRRLYRSMNSQYLKLLSSQKYQILLYNGDVDMACNFMGDEWFVDSLNQKMEVQRRPWLVKYGDSGEQIAGFVKEFSHIAFLTIKGAGHMVPTDKPLAAFTMFSRFLNKQPY

Target ORF information:

RefSeq Version	NM_000308.3
Organism	Homo sapiens(human)
Definition	Homo sapiens cathepsin A (CTSA), transcript variant 1, mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_000308.3

ORF Insert Sequence:

ATGACTTCCA GTCCCCGGGC GCCTCCTGGA GAGCAAGGAC GCGGGGGAGC AGAGATGATC 
CGAGCCGCGC CGCCGCCGCT GTTCCTGCTG CTGCTGCTGC TGCTGCTGCT AGTGTCCTGG 
GCGTCCCGAG GCGAGGCAGC CCCCGACCAG GACGAGATCC AGCGCCTCCC CGGGCTGGCC 
AAGCAGCCGT CTTTCCGCCA GTACTCCGGC TACCTCAAAG GCTCCGGCTC CAAGCACCTC 
CACTACTGGT TTGTGGAGTC CCAGAAGGAT CCCGAGAACA GCCCTGTGGT GCTTTGGCTC 
AATGGGGGTC CCGGCTGCAG CTCACTAGAT GGGCTCCTCA CAGAGCATGG CCCCTTCCTG 
GTCCAGCCAG ATGGTGTCAC CCTGGAGTAC AACCCCTATT CTTGGAATCT GATTGCCAAT 
GTGTTATACC TGGAGTCCCC AGCTGGGGTG GGCTTCTCCT ACTCCGATGA CAAGTTTTAT 
GCAACTAATG ACACTGAGGT CGCCCAGAGC AATTTTGAGG CCCTTCAAGA TTTCTTCCGC 
CTCTTTCCGG AGTACAAGAA CAACAAACTT TTCCTGACCG GGGAGAGCTA TGCTGGCATC 
TACATCCCCA CCCTGGCCGT GCTGGTCATG CAGGATCCCA GCATGAACCT TCAGGGGCTG 
GCTGTGGGCA ATGGACTCTC CTCCTATGAG CAGAATGACA ACTCCCTGGT CTACTTTGCC 
TACTACCATG GCCTTCTGGG GAACAGGCTT TGGTCTTCTC TCCAGACCCA CTGCTGCTCT 
CAAAACAAGT GTAACTTCTA TGACAACAAA GACCTGGAAT GCGTGACCAA TCTTCAGGAA 
GTGGCCCGCA TCGTGGGCAA CTCTGGCCTC AACATCTACA ATCTCTATGC CCCGTGTGCT 
GGAGGGGTGC CCAGCCATTT TAGGTATGAG AAGGACACTG TTGTGGTCCA GGATTTGGGC 
AACATCTTCA CTCGCCTGCC ACTCAAGCGG ATGTGGCATC AGGCACTGCT GCGCTCAGGG 
GATAAAGTGC GCATGGACCC CCCCTGCACC AACACAACAG CTGCTTCCAC CTACCTCAAC 
AACCCGTACG TGCGGAAGGC CCTCAACATC CCGGAGCAGC TGCCACAATG GGACATGTGC 
AACTTTCTGG TAAACTTACA GTACCGCCGT CTCTACCGAA GCATGAACTC CCAGTATCTG 
AAGCTGCTTA GCTCACAGAA ATACCAGATC CTATTATATA ATGGAGATGT AGACATGGCC 
TGCAATTTCA TGGGGGATGA GTGGTTTGTG GATTCCCTCA ACCAGAAGAT GGAGGTGCAG 
CGCCGGCCCT GGTTAGTGAA GTACGGGGAC AGCGGGGAGC AGATTGCCGG CTTCGTGAAG 
GAGTTCTCCC ACATCGCCTT TCTCACGATC AAGGGCGCCG GCCACATGGT TCCCACCGAC 
AAGCCCCTCG CTGCCTTCAC CATGTTCTCC CGCTTCCTGA ACAAGCAGCC ATACTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

CTSA ( NM_001167594.2 ) cDNA ORF clone, Homo sapiens(human) -> NP_001161066.1 Homo sapiens cathepsin A (CTSA), transcript variant 3, mRNA.

Price & Availability↑

CloneID	OHu04054
Clone ID Related Accession (Same CDS sequence)	NM_001167594.2
Accession Version	NM_001167594.2 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 1446bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-06-03
Organism	Homo sapiens(human)
Product	lysosomal protective protein isoform c precursor
Comment	Comment: REVIEWED REFSEQ: This record has been curated by NCBI staff. The reference sequence was derived from AK172808.1, AL008726.3, DA029446.1, AK304536.1, BC000597.2 and BC093009.1. On Nov 13, 2015 this sequence version replaced NM_001167594.1. Transcript Variant: This variant (3) lacks an alternate in-frame exon in the 5' coding region compared to variant 1. The encoded isoform (c) is shorter than isoform a. This isoform may undergo proteolytic processing similar to isoform b. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: SRR1803616.10047.1, SRR1660803.134968.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA1965299, SAMEA1968189 [ECO:0000348] ##Evidence-Data-END## COMPLETENESS: complete on the 3' end.

ATGACTTCCA GTCCCCGGGC GCCTCCTGGA GAGCAAGGAC GCGGGGGAGC AGAGATGATC 
CGAGCCGCGC CGCCGCCGCT GTTCCTGCTG CTGCTGCTGC TGCTGCTGCT AGTGTCCTGG 
GCGTCCCGAG GCGAGGCAGC CCCCGACCAG GACGAGATCC AGCGCCTCCC CGGGCTGGCC 
AAGCAGCCGT CTTTCCGCCA GTACTCCGGC TACCTCAAAG GCTCCGGCTC CAAGCACCTC 
CACTACTGGT TTGTGGAGTC CCAGAAGGAT CCCGAGAACA GCCCTGTGGT GCTTTGGCTC 
AATGGGGGTC CCGGCTGCAG CTCACTAGAT GGGCTCCTCA CAGAGCATGG CCCCTTCCTG 
ATTGCCAATG TGTTATACCT GGAGTCCCCA GCTGGGGTGG GCTTCTCCTA CTCCGATGAC 
AAGTTTTATG CAACTAATGA CACTGAGGTC GCCCAGAGCA ATTTTGAGGC CCTTCAAGAT 
TTCTTCCGCC TCTTTCCGGA GTACAAGAAC AACAAACTTT TCCTGACCGG GGAGAGCTAT 
GCTGGCATCT ACATCCCCAC CCTGGCCGTG CTGGTCATGC AGGATCCCAG CATGAACCTT 
CAGGGGCTGG CTGTGGGCAA TGGACTCTCC TCCTATGAGC AGAATGACAA CTCCCTGGTC 
TACTTTGCCT ACTACCATGG CCTTCTGGGG AACAGGCTTT GGTCTTCTCT CCAGACCCAC 
TGCTGCTCTC AAAACAAGTG TAACTTCTAT GACAACAAAG ACCTGGAATG CGTGACCAAT 
CTTCAGGAAG TGGCCCGCAT CGTGGGCAAC TCTGGCCTCA ACATCTACAA TCTCTATGCC 
CCGTGTGCTG GAGGGGTGCC CAGCCATTTT AGGTATGAGA AGGACACTGT TGTGGTCCAG 
GATTTGGGCA ACATCTTCAC TCGCCTGCCA CTCAAGCGGA TGTGGCATCA GGCACTGCTG 
CGCTCAGGGG ATAAAGTGCG CATGGACCCC CCCTGCACCA ACACAACAGC TGCTTCCACC 
TACCTCAACA ACCCGTACGT GCGGAAGGCC CTCAACATCC CGGAGCAGCT GCCACAATGG 
GACATGTGCA ACTTTCTGGT AAACTTACAG TACCGCCGTC TCTACCGAAG CATGAACTCC 
CAGTATCTGA AGCTGCTTAG CTCACAGAAA TACCAGATCC TATTATATAA TGGAGATGTA 
GACATGGCCT GCAATTTCAT GGGGGATGAG TGGTTTGTGG ATTCCCTCAA CCAGAAGATG 
GAGGTGCAGC GCCGGCCCTG GTTAGTGAAG TACGGGGACA GCGGGGAGCA GATTGCCGGC 
TTCGTGAAGG AGTTCTCCCA CATCGCCTTT CTCACGATCA AGGGCGCCGG CCACATGGTT 
CCCACCGACA AGCCCCTCGC TGCCTTCACC ATGTTCTCCC GCTTCCTGAA CAAGCAGCCA 
TACTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_001161066.1
CDS	1183..2628
Translation	MTSSPRAPPGEQGRGGAEMIRAAPPPLFLLLLLLLLLVSWASRGEAAPDQDEIQRLPGLAKQPSFRQYSGYLKGSGSKHLHYWFVESQKDPENSPVVLWLNGGPGCSSLDGLLTEHGPFLIANVLYLESPAGVGFSYSDDKFYATNDTEVAQSNFEALQDFFRLFPEYKNNKLFLTGESYAGIYIPTLAVLVMQDPSMNLQGLAVGNGLSSYEQNDNSLVYFAYYHGLLGNRLWSSLQTHCCSQNKCNFYDNKDLECVTNLQEVARIVGNSGLNIYNLYAPCAGGVPSHFRYEKDTVVVQDLGNIFTRLPLKRMWHQALLRSGDKVRMDPPCTNTTAASTYLNNPYVRKALNIPEQLPQWDMCNFLVNLQYRRLYRSMNSQYLKLLSSQKYQILLYNGDVDMACNFMGDEWFVDSLNQKMEVQRRPWLVKYGDSGEQIAGFVKEFSHIAFLTIKGAGHMVPTDKPLAAFTMFSRFLNKQPY

Target ORF information:

RefSeq Version	NM_001167594.2
Organism	Homo sapiens(human)
Definition	Homo sapiens cathepsin A (CTSA), transcript variant 3, mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_001167594.2

ORF Insert Sequence:

ATGACTTCCA GTCCCCGGGC GCCTCCTGGA GAGCAAGGAC GCGGGGGAGC AGAGATGATC 
CGAGCCGCGC CGCCGCCGCT GTTCCTGCTG CTGCTGCTGC TGCTGCTGCT AGTGTCCTGG 
GCGTCCCGAG GCGAGGCAGC CCCCGACCAG GACGAGATCC AGCGCCTCCC CGGGCTGGCC 
AAGCAGCCGT CTTTCCGCCA GTACTCCGGC TACCTCAAAG GCTCCGGCTC CAAGCACCTC 
CACTACTGGT TTGTGGAGTC CCAGAAGGAT CCCGAGAACA GCCCTGTGGT GCTTTGGCTC 
AATGGGGGTC CCGGCTGCAG CTCACTAGAT GGGCTCCTCA CAGAGCATGG CCCCTTCCTG 
ATTGCCAATG TGTTATACCT GGAGTCCCCA GCTGGGGTGG GCTTCTCCTA CTCCGATGAC 
AAGTTTTATG CAACTAATGA CACTGAGGTC GCCCAGAGCA ATTTTGAGGC CCTTCAAGAT 
TTCTTCCGCC TCTTTCCGGA GTACAAGAAC AACAAACTTT TCCTGACCGG GGAGAGCTAT 
GCTGGCATCT ACATCCCCAC CCTGGCCGTG CTGGTCATGC AGGATCCCAG CATGAACCTT 
CAGGGGCTGG CTGTGGGCAA TGGACTCTCC TCCTATGAGC AGAATGACAA CTCCCTGGTC 
TACTTTGCCT ACTACCATGG CCTTCTGGGG AACAGGCTTT GGTCTTCTCT CCAGACCCAC 
TGCTGCTCTC AAAACAAGTG TAACTTCTAT GACAACAAAG ACCTGGAATG CGTGACCAAT 
CTTCAGGAAG TGGCCCGCAT CGTGGGCAAC TCTGGCCTCA ACATCTACAA TCTCTATGCC 
CCGTGTGCTG GAGGGGTGCC CAGCCATTTT AGGTATGAGA AGGACACTGT TGTGGTCCAG 
GATTTGGGCA ACATCTTCAC TCGCCTGCCA CTCAAGCGGA TGTGGCATCA GGCACTGCTG 
CGCTCAGGGG ATAAAGTGCG CATGGACCCC CCCTGCACCA ACACAACAGC TGCTTCCACC 
TACCTCAACA ACCCGTACGT GCGGAAGGCC CTCAACATCC CGGAGCAGCT GCCACAATGG 
GACATGTGCA ACTTTCTGGT AAACTTACAG TACCGCCGTC TCTACCGAAG CATGAACTCC 
CAGTATCTGA AGCTGCTTAG CTCACAGAAA TACCAGATCC TATTATATAA TGGAGATGTA 
GACATGGCCT GCAATTTCAT GGGGGATGAG TGGTTTGTGG ATTCCCTCAA CCAGAAGATG 
GAGGTGCAGC GCCGGCCCTG GTTAGTGAAG TACGGGGACA GCGGGGAGCA GATTGCCGGC 
TTCGTGAAGG AGTTCTCCCA CATCGCCTTT CTCACGATCA AGGGCGCCGG CCACATGGTT 
CCCACCGACA AGCCCCTCGC TGCCTTCACC ATGTTCTCCC GCTTCCTGAA CAAGCAGCCA 
TACTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

CTSA ( NM_001127695.1 ) cDNA ORF clone, Homo sapiens(human) -> NP_001121167.1 Homo sapiens cathepsin A (CTSA), transcript variant 2, mRNA.

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CloneID	OHu06757
Clone ID Related Accession (Same CDS sequence)	NM_000308.4 , NM_001127695.1 , NM_001127695.2
Accession Version	NM_001127695.1	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 1443bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2015-03-14
Organism	Homo sapiens(Human)
Product	lysosomal protective protein isoform b precursor
Comment

ATGATCCGAG CCGCGCCGCC GCCGCTGTTC CTGCTGCTGC TGCTGCTGCT GCTGCTAGTG 
TCCTGGGCGT CCCGAGGCGA GGCAGCCCCC GACCAGGACG AGATCCAGCG CCTCCCCGGG 
CTGGCCAAGC AGCCGTCTTT CCGCCAGTAC TCCGGCTACC TCAAAGGCTC CGGCTCCAAG 
CACCTCCACT ACTGGTTTGT GGAGTCCCAG AAGGATCCCG AGAACAGCCC TGTGGTGCTT 
TGGCTCAATG GGGGTCCCGG CTGCAGCTCA CTAGATGGGC TCCTCACAGA GCATGGCCCC 
TTCCTGGTCC AGCCAGATGG TGTCACCCTG GAGTACAACC CCTATTCTTG GAATCTGATT 
GCCAATGTGT TATACCTGGA GTCCCCAGCT GGGGTGGGCT TCTCCTACTC CGATGACAAG 
TTTTATGCAA CTAATGACAC TGAGGTCGCC CAGAGCAATT TTGAGGCCCT TCAAGATTTC 
TTCCGCCTCT TTCCGGAGTA CAAGAACAAC AAACTTTTCC TGACCGGGGA GAGCTATGCT 
GGCATCTACA TCCCCACCCT GGCCGTGCTG GTCATGCAGG ATCCCAGCAT GAACCTTCAG 
GGGCTGGCTG TGGGCAATGG ACTCTCCTCC TATGAGCAGA ATGACAACTC CCTGGTCTAC 
TTTGCCTACT ACCATGGCCT TCTGGGGAAC AGGCTTTGGT CTTCTCTCCA GACCCACTGC 
TGCTCTCAAA ACAAGTGTAA CTTCTATGAC AACAAAGACC TGGAATGCGT GACCAATCTT 
CAGGAAGTGG CCCGCATCGT GGGCAACTCT GGCCTCAACA TCTACAATCT CTATGCCCCG 
TGTGCTGGAG GGGTGCCCAG CCATTTTAGG TATGAGAAGG ACACTGTTGT GGTCCAGGAT 
TTGGGCAACA TCTTCACTCG CCTGCCACTC AAGCGGATGT GGCATCAGGC ACTGCTGCGC 
TCAGGGGATA AAGTGCGCAT GGACCCCCCC TGCACCAACA CAACAGCTGC TTCCACCTAC 
CTCAACAACC CGTACGTGCG GAAGGCCCTC AACATCCCGG AGCAGCTGCC ACAATGGGAC 
ATGTGCAACT TTCTGGTAAA CTTACAGTAC CGCCGTCTCT ACCGAAGCAT GAACTCCCAG 
TATCTGAAGC TGCTTAGCTC ACAGAAATAC CAGATCCTAT TATATAATGG AGATGTAGAC 
ATGGCCTGCA ATTTCATGGG GGATGAGTGG TTTGTGGATT CCCTCAACCA GAAGATGGAG 
GTGCAGCGCC GGCCCTGGTT AGTGAAGTAC GGGGACAGCG GGGAGCAGAT TGCCGGCTTC 
GTGAAGGAGT TCTCCCACAT CGCCTTTCTC ACGATCAAGG GCGCCGGCCA CATGGTTCCC 
ACCGACAAGC CCCTCGCTGC CTTCACCATG TTCTCCCGCT TCCTGAACAA GCAGCCATAC 
TGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq

NP_001121167.1

Translation

MIRAAPPPLFLLLLLLLLLVSWASRGEAAPDQDEIQRLPGLAKQPSFRQYSGYLKGSGSKHLHYWFVESQKDPENSPVVLWLNGGPGCSSLDGLLTEHGPFLVQPDGVTLEYNPYSWNLIANVLYLESPAGVGFSYSDDKFYATNDTEVAQSNFEALQDFFRLFPEYKNNKLFLTGESYAGIYIPTLAVLVMQDPSMNLQGLAVGNGLSSYEQNDNSLVYFAYYHGLLGNRLWSSLQTHCCSQNKCNFYDNKDLECVTNLQEVARIVGNSGLNIYNLYAPCAGGVPSHFRYEKDTVVVQDLGNIFTRLPLKRMWHQALLRSGDKVRMDPPCTNTTAASTYLNNPYVRKALNIPEQLPQWDMCNFLVNLQYRRLYRSMNSQYLKLLSSQKYQILLYNGDVDMACNFMGDEWFVDSLNQKMEVQRRPWLVKYGDSGEQIAGFVKEFSHIAFLTIKGAGHMVPTDKPLAAFTMFSRFLNKQPY

Target ORF information:

RefSeq Version	NM_001127695.1
Organism	Homo sapiens(Human)
Definition	Homo sapiens cathepsin A (CTSA), transcript variant 2, mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_001127695.1

ORF Insert Sequence:

ATGATCCGAG CCGCGCCGCC GCCGCTGTTC CTGCTGCTGC TGCTGCTGCT GCTGCTAGTG 
TCCTGGGCGT CCCGAGGCGA GGCAGCCCCC GACCAGGACG AGATCCAGCG CCTCCCCGGG 
CTGGCCAAGC AGCCGTCTTT CCGCCAGTAC TCCGGCTACC TCAAAGGCTC CGGCTCCAAG 
CACCTCCACT ACTGGTTTGT GGAGTCCCAG AAGGATCCCG AGAACAGCCC TGTGGTGCTT 
TGGCTCAATG GGGGTCCCGG CTGCAGCTCA CTAGATGGGC TCCTCACAGA GCATGGCCCC 
TTCCTGGTCC AGCCAGATGG TGTCACCCTG GAGTACAACC CCTATTCTTG GAATCTGATT 
GCCAATGTGT TATACCTGGA GTCCCCAGCT GGGGTGGGCT TCTCCTACTC CGATGACAAG 
TTTTATGCAA CTAATGACAC TGAGGTCGCC CAGAGCAATT TTGAGGCCCT TCAAGATTTC 
TTCCGCCTCT TTCCGGAGTA CAAGAACAAC AAACTTTTCC TGACCGGGGA GAGCTATGCT 
GGCATCTACA TCCCCACCCT GGCCGTGCTG GTCATGCAGG ATCCCAGCAT GAACCTTCAG 
GGGCTGGCTG TGGGCAATGG ACTCTCCTCC TATGAGCAGA ATGACAACTC CCTGGTCTAC 
TTTGCCTACT ACCATGGCCT TCTGGGGAAC AGGCTTTGGT CTTCTCTCCA GACCCACTGC 
TGCTCTCAAA ACAAGTGTAA CTTCTATGAC AACAAAGACC TGGAATGCGT GACCAATCTT 
CAGGAAGTGG CCCGCATCGT GGGCAACTCT GGCCTCAACA TCTACAATCT CTATGCCCCG 
TGTGCTGGAG GGGTGCCCAG CCATTTTAGG TATGAGAAGG ACACTGTTGT GGTCCAGGAT 
TTGGGCAACA TCTTCACTCG CCTGCCACTC AAGCGGATGT GGCATCAGGC ACTGCTGCGC 
TCAGGGGATA AAGTGCGCAT GGACCCCCCC TGCACCAACA CAACAGCTGC TTCCACCTAC 
CTCAACAACC CGTACGTGCG GAAGGCCCTC AACATCCCGG AGCAGCTGCC ACAATGGGAC 
ATGTGCAACT TTCTGGTAAA CTTACAGTAC CGCCGTCTCT ACCGAAGCAT GAACTCCCAG 
TATCTGAAGC TGCTTAGCTC ACAGAAATAC CAGATCCTAT TATATAATGG AGATGTAGAC 
ATGGCCTGCA ATTTCATGGG GGATGAGTGG TTTGTGGATT CCCTCAACCA GAAGATGGAG 
GTGCAGCGCC GGCCCTGGTT AGTGAAGTAC GGGGACAGCG GGGAGCAGAT TGCCGGCTTC 
GTGAAGGAGT TCTCCCACAT CGCCTTTCTC ACGATCAAGG GCGCCGGCCA CATGGTTCCC 
ACCGACAAGC CCCTCGCTGC CTTCACCATG TTCTCCCGCT TCCTGAACAA GCAGCCATAC 
TGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

CTSA ( NM_001127695.2 ) cDNA ORF clone, Homo sapiens(human) -> NP_001121167.1 Homo sapiens cathepsin A (CTSA), transcript variant 2, mRNA.

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CloneID	OHu06757
Clone ID Related Accession (Same CDS sequence)	NM_000308.4 , NM_001127695.1 , NM_001127695.2
Accession Version	NM_001127695.2 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 1443bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-06-03
Organism	Homo sapiens(human)
Product	lysosomal protective protein isoform b preproprotein
Comment	Comment: REVIEWED REFSEQ: This record has been curated by NCBI staff. The reference sequence was derived from AK172808.1, AL008726.3, DA029446.1, AK307701.1 and BC093009.1. On Nov 13, 2015 this sequence version replaced NM_001127695.1. Transcript Variant: This variant (2) differs in the 5' UTR, lacks a portion of the 5' coding region, and initiates translation at a downstream start codon compared to variant 1. The encoded isoform (b) has a shorter N-terminus compared to isoform a. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: SRR5189661.58443.1, SRR5189658.205607.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA1968189, SAMEA1968540 [ECO:0000348] ##Evidence-Data-END## COMPLETENESS: complete on the 3' end.

ATGATCCGAG CCGCGCCGCC GCCGCTGTTC CTGCTGCTGC TGCTGCTGCT GCTGCTAGTG 
TCCTGGGCGT CCCGAGGCGA GGCAGCCCCC GACCAGGACG AGATCCAGCG CCTCCCCGGG 
CTGGCCAAGC AGCCGTCTTT CCGCCAGTAC TCCGGCTACC TCAAAGGCTC CGGCTCCAAG 
CACCTCCACT ACTGGTTTGT GGAGTCCCAG AAGGATCCCG AGAACAGCCC TGTGGTGCTT 
TGGCTCAATG GGGGTCCCGG CTGCAGCTCA CTAGATGGGC TCCTCACAGA GCATGGCCCC 
TTCCTGGTCC AGCCAGATGG TGTCACCCTG GAGTACAACC CCTATTCTTG GAATCTGATT 
GCCAATGTGT TATACCTGGA GTCCCCAGCT GGGGTGGGCT TCTCCTACTC CGATGACAAG 
TTTTATGCAA CTAATGACAC TGAGGTCGCC CAGAGCAATT TTGAGGCCCT TCAAGATTTC 
TTCCGCCTCT TTCCGGAGTA CAAGAACAAC AAACTTTTCC TGACCGGGGA GAGCTATGCT 
GGCATCTACA TCCCCACCCT GGCCGTGCTG GTCATGCAGG ATCCCAGCAT GAACCTTCAG 
GGGCTGGCTG TGGGCAATGG ACTCTCCTCC TATGAGCAGA ATGACAACTC CCTGGTCTAC 
TTTGCCTACT ACCATGGCCT TCTGGGGAAC AGGCTTTGGT CTTCTCTCCA GACCCACTGC 
TGCTCTCAAA ACAAGTGTAA CTTCTATGAC AACAAAGACC TGGAATGCGT GACCAATCTT 
CAGGAAGTGG CCCGCATCGT GGGCAACTCT GGCCTCAACA TCTACAATCT CTATGCCCCG 
TGTGCTGGAG GGGTGCCCAG CCATTTTAGG TATGAGAAGG ACACTGTTGT GGTCCAGGAT 
TTGGGCAACA TCTTCACTCG CCTGCCACTC AAGCGGATGT GGCATCAGGC ACTGCTGCGC 
TCAGGGGATA AAGTGCGCAT GGACCCCCCC TGCACCAACA CAACAGCTGC TTCCACCTAC 
CTCAACAACC CGTACGTGCG GAAGGCCCTC AACATCCCGG AGCAGCTGCC ACAATGGGAC 
ATGTGCAACT TTCTGGTAAA CTTACAGTAC CGCCGTCTCT ACCGAAGCAT GAACTCCCAG 
TATCTGAAGC TGCTTAGCTC ACAGAAATAC CAGATCCTAT TATATAATGG AGATGTAGAC 
ATGGCCTGCA ATTTCATGGG GGATGAGTGG TTTGTGGATT CCCTCAACCA GAAGATGGAG 
GTGCAGCGCC GGCCCTGGTT AGTGAAGTAC GGGGACAGCG GGGAGCAGAT TGCCGGCTTC 
GTGAAGGAGT TCTCCCACAT CGCCTTTCTC ACGATCAAGG GCGCCGGCCA CATGGTTCCC 
ACCGACAAGC CCCTCGCTGC CTTCACCATG TTCTCCCGCT TCCTGAACAA GCAGCCATAC 
TGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_001121167.1
CDS	1283..2725
Translation	MIRAAPPPLFLLLLLLLLLVSWASRGEAAPDQDEIQRLPGLAKQPSFRQYSGYLKGSGSKHLHYWFVESQKDPENSPVVLWLNGGPGCSSLDGLLTEHGPFLVQPDGVTLEYNPYSWNLIANVLYLESPAGVGFSYSDDKFYATNDTEVAQSNFEALQDFFRLFPEYKNNKLFLTGESYAGIYIPTLAVLVMQDPSMNLQGLAVGNGLSSYEQNDNSLVYFAYYHGLLGNRLWSSLQTHCCSQNKCNFYDNKDLECVTNLQEVARIVGNSGLNIYNLYAPCAGGVPSHFRYEKDTVVVQDLGNIFTRLPLKRMWHQALLRSGDKVRMDPPCTNTTAASTYLNNPYVRKALNIPEQLPQWDMCNFLVNLQYRRLYRSMNSQYLKLLSSQKYQILLYNGDVDMACNFMGDEWFVDSLNQKMEVQRRPWLVKYGDSGEQIAGFVKEFSHIAFLTIKGAGHMVPTDKPLAAFTMFSRFLNKQPY

Target ORF information:

RefSeq Version	NM_001127695.2
Organism	Homo sapiens(human)
Definition	Homo sapiens cathepsin A (CTSA), transcript variant 2, mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_001127695.2

ORF Insert Sequence:

ATGATCCGAG CCGCGCCGCC GCCGCTGTTC CTGCTGCTGC TGCTGCTGCT GCTGCTAGTG 
TCCTGGGCGT CCCGAGGCGA GGCAGCCCCC GACCAGGACG AGATCCAGCG CCTCCCCGGG 
CTGGCCAAGC AGCCGTCTTT CCGCCAGTAC TCCGGCTACC TCAAAGGCTC CGGCTCCAAG 
CACCTCCACT ACTGGTTTGT GGAGTCCCAG AAGGATCCCG AGAACAGCCC TGTGGTGCTT 
TGGCTCAATG GGGGTCCCGG CTGCAGCTCA CTAGATGGGC TCCTCACAGA GCATGGCCCC 
TTCCTGGTCC AGCCAGATGG TGTCACCCTG GAGTACAACC CCTATTCTTG GAATCTGATT 
GCCAATGTGT TATACCTGGA GTCCCCAGCT GGGGTGGGCT TCTCCTACTC CGATGACAAG 
TTTTATGCAA CTAATGACAC TGAGGTCGCC CAGAGCAATT TTGAGGCCCT TCAAGATTTC 
TTCCGCCTCT TTCCGGAGTA CAAGAACAAC AAACTTTTCC TGACCGGGGA GAGCTATGCT 
GGCATCTACA TCCCCACCCT GGCCGTGCTG GTCATGCAGG ATCCCAGCAT GAACCTTCAG 
GGGCTGGCTG TGGGCAATGG ACTCTCCTCC TATGAGCAGA ATGACAACTC CCTGGTCTAC 
TTTGCCTACT ACCATGGCCT TCTGGGGAAC AGGCTTTGGT CTTCTCTCCA GACCCACTGC 
TGCTCTCAAA ACAAGTGTAA CTTCTATGAC AACAAAGACC TGGAATGCGT GACCAATCTT 
CAGGAAGTGG CCCGCATCGT GGGCAACTCT GGCCTCAACA TCTACAATCT CTATGCCCCG 
TGTGCTGGAG GGGTGCCCAG CCATTTTAGG TATGAGAAGG ACACTGTTGT GGTCCAGGAT 
TTGGGCAACA TCTTCACTCG CCTGCCACTC AAGCGGATGT GGCATCAGGC ACTGCTGCGC 
TCAGGGGATA AAGTGCGCAT GGACCCCCCC TGCACCAACA CAACAGCTGC TTCCACCTAC 
CTCAACAACC CGTACGTGCG GAAGGCCCTC AACATCCCGG AGCAGCTGCC ACAATGGGAC 
ATGTGCAACT TTCTGGTAAA CTTACAGTAC CGCCGTCTCT ACCGAAGCAT GAACTCCCAG 
TATCTGAAGC TGCTTAGCTC ACAGAAATAC CAGATCCTAT TATATAATGG AGATGTAGAC 
ATGGCCTGCA ATTTCATGGG GGATGAGTGG TTTGTGGATT CCCTCAACCA GAAGATGGAG 
GTGCAGCGCC GGCCCTGGTT AGTGAAGTAC GGGGACAGCG GGGAGCAGAT TGCCGGCTTC 
GTGAAGGAGT TCTCCCACAT CGCCTTTCTC ACGATCAAGG GCGCCGGCCA CATGGTTCCC 
ACCGACAAGC CCCTCGCTGC CTTCACCATG TTCTCCCGCT TCCTGAACAA GCAGCCATAC 
TGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

CTSA ( NM_000308.4 ) cDNA ORF clone, Homo sapiens(human) -> NP_000299.3 Homo sapiens cathepsin A (CTSA), transcript variant 1, mRNA.

Price & Availability↑

CloneID	OHu06757
Clone ID Related Accession (Same CDS sequence)	NM_000308.4 , NM_001127695.1 , NM_001127695.2
Accession Version	NM_000308.4 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 1443bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-10-22
Organism	Homo sapiens(human)
Product	lysosomal protective protein isoform a precursor
Comment	Comment: REVIEWED REFSEQ: This record has been curated by NCBI staff. The reference sequence was derived from BC093009.1. On Sep 18, 2019 this sequence version replaced NM_000308.3. Transcript Variant: This variant (1) encodes the longest isoform (a). This isoform (a) may undergo proteolytic processing similar to isoform (b). Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##RefSeq-Attributes-START## RefSeq Select criteria :: based on manual assertion, conservation, expression ##RefSeq-Attributes-END## COMPLETENESS: complete on the 3' end.

ATGATCCGAG CCGCGCCGCC GCCGCTGTTC CTGCTGCTGC TGCTGCTGCT GCTGCTAGTG 
TCCTGGGCGT CCCGAGGCGA GGCAGCCCCC GACCAGGACG AGATCCAGCG CCTCCCCGGG 
CTGGCCAAGC AGCCGTCTTT CCGCCAGTAC TCCGGCTACC TCAAAGGCTC CGGCTCCAAG 
CACCTCCACT ACTGGTTTGT GGAGTCCCAG AAGGATCCCG AGAACAGCCC TGTGGTGCTT 
TGGCTCAATG GGGGTCCCGG CTGCAGCTCA CTAGATGGGC TCCTCACAGA GCATGGCCCC 
TTCCTGGTCC AGCCAGATGG TGTCACCCTG GAGTACAACC CCTATTCTTG GAATCTGATT 
GCCAATGTGT TATACCTGGA GTCCCCAGCT GGGGTGGGCT TCTCCTACTC CGATGACAAG 
TTTTATGCAA CTAATGACAC TGAGGTCGCC CAGAGCAATT TTGAGGCCCT TCAAGATTTC 
TTCCGCCTCT TTCCGGAGTA CAAGAACAAC AAACTTTTCC TGACCGGGGA GAGCTATGCT 
GGCATCTACA TCCCCACCCT GGCCGTGCTG GTCATGCAGG ATCCCAGCAT GAACCTTCAG 
GGGCTGGCTG TGGGCAATGG ACTCTCCTCC TATGAGCAGA ATGACAACTC CCTGGTCTAC 
TTTGCCTACT ACCATGGCCT TCTGGGGAAC AGGCTTTGGT CTTCTCTCCA GACCCACTGC 
TGCTCTCAAA ACAAGTGTAA CTTCTATGAC AACAAAGACC TGGAATGCGT GACCAATCTT 
CAGGAAGTGG CCCGCATCGT GGGCAACTCT GGCCTCAACA TCTACAATCT CTATGCCCCG 
TGTGCTGGAG GGGTGCCCAG CCATTTTAGG TATGAGAAGG ACACTGTTGT GGTCCAGGAT 
TTGGGCAACA TCTTCACTCG CCTGCCACTC AAGCGGATGT GGCATCAGGC ACTGCTGCGC 
TCAGGGGATA AAGTGCGCAT GGACCCCCCC TGCACCAACA CAACAGCTGC TTCCACCTAC 
CTCAACAACC CGTACGTGCG GAAGGCCCTC AACATCCCGG AGCAGCTGCC ACAATGGGAC 
ATGTGCAACT TTCTGGTAAA CTTACAGTAC CGCCGTCTCT ACCGAAGCAT GAACTCCCAG 
TATCTGAAGC TGCTTAGCTC ACAGAAATAC CAGATCCTAT TATATAATGG AGATGTAGAC 
ATGGCCTGCA ATTTCATGGG GGATGAGTGG TTTGTGGATT CCCTCAACCA GAAGATGGAG 
GTGCAGCGCC GGCCCTGGTT AGTGAAGTAC GGGGACAGCG GGGAGCAGAT TGCCGGCTTC 
GTGAAGGAGT TCTCCCACAT CGCCTTTCTC ACGATCAAGG GCGCCGGCCA CATGGTTCCC 
ACCGACAAGC CCCTCGCTGC CTTCACCATG TTCTCCCGCT TCCTGAACAA GCAGCCATAC 
TGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_000299.3
CDS	46..1488
Translation	MIRAAPPPLFLLLLLLLLLVSWASRGEAAPDQDEIQRLPGLAKQPSFRQYSGYLKGSGSKHLHYWFVESQKDPENSPVVLWLNGGPGCSSLDGLLTEHGPFLVQPDGVTLEYNPYSWNLIANVLYLESPAGVGFSYSDDKFYATNDTEVAQSNFEALQDFFRLFPEYKNNKLFLTGESYAGIYIPTLAVLVMQDPSMNLQGLAVGNGLSSYEQNDNSLVYFAYYHGLLGNRLWSSLQTHCCSQNKCNFYDNKDLECVTNLQEVARIVGNSGLNIYNLYAPCAGGVPSHFRYEKDTVVVQDLGNIFTRLPLKRMWHQALLRSGDKVRMDPPCTNTTAASTYLNNPYVRKALNIPEQLPQWDMCNFLVNLQYRRLYRSMNSQYLKLLSSQKYQILLYNGDVDMACNFMGDEWFVDSLNQKMEVQRRPWLVKYGDSGEQIAGFVKEFSHIAFLTIKGAGHMVPTDKPLAAFTMFSRFLNKQPY

Target ORF information:

RefSeq Version	NM_000308.4
Organism	Homo sapiens(human)
Definition	Homo sapiens cathepsin A (CTSA), transcript variant 1, mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_000308.4

ORF Insert Sequence:

ATGATCCGAG CCGCGCCGCC GCCGCTGTTC CTGCTGCTGC TGCTGCTGCT GCTGCTAGTG 
TCCTGGGCGT CCCGAGGCGA GGCAGCCCCC GACCAGGACG AGATCCAGCG CCTCCCCGGG 
CTGGCCAAGC AGCCGTCTTT CCGCCAGTAC TCCGGCTACC TCAAAGGCTC CGGCTCCAAG 
CACCTCCACT ACTGGTTTGT GGAGTCCCAG AAGGATCCCG AGAACAGCCC TGTGGTGCTT 
TGGCTCAATG GGGGTCCCGG CTGCAGCTCA CTAGATGGGC TCCTCACAGA GCATGGCCCC 
TTCCTGGTCC AGCCAGATGG TGTCACCCTG GAGTACAACC CCTATTCTTG GAATCTGATT 
GCCAATGTGT TATACCTGGA GTCCCCAGCT GGGGTGGGCT TCTCCTACTC CGATGACAAG 
TTTTATGCAA CTAATGACAC TGAGGTCGCC CAGAGCAATT TTGAGGCCCT TCAAGATTTC 
TTCCGCCTCT TTCCGGAGTA CAAGAACAAC AAACTTTTCC TGACCGGGGA GAGCTATGCT 
GGCATCTACA TCCCCACCCT GGCCGTGCTG GTCATGCAGG ATCCCAGCAT GAACCTTCAG 
GGGCTGGCTG TGGGCAATGG ACTCTCCTCC TATGAGCAGA ATGACAACTC CCTGGTCTAC 
TTTGCCTACT ACCATGGCCT TCTGGGGAAC AGGCTTTGGT CTTCTCTCCA GACCCACTGC 
TGCTCTCAAA ACAAGTGTAA CTTCTATGAC AACAAAGACC TGGAATGCGT GACCAATCTT 
CAGGAAGTGG CCCGCATCGT GGGCAACTCT GGCCTCAACA TCTACAATCT CTATGCCCCG 
TGTGCTGGAG GGGTGCCCAG CCATTTTAGG TATGAGAAGG ACACTGTTGT GGTCCAGGAT 
TTGGGCAACA TCTTCACTCG CCTGCCACTC AAGCGGATGT GGCATCAGGC ACTGCTGCGC 
TCAGGGGATA AAGTGCGCAT GGACCCCCCC TGCACCAACA CAACAGCTGC TTCCACCTAC 
CTCAACAACC CGTACGTGCG GAAGGCCCTC AACATCCCGG AGCAGCTGCC ACAATGGGAC 
ATGTGCAACT TTCTGGTAAA CTTACAGTAC CGCCGTCTCT ACCGAAGCAT GAACTCCCAG 
TATCTGAAGC TGCTTAGCTC ACAGAAATAC CAGATCCTAT TATATAATGG AGATGTAGAC 
ATGGCCTGCA ATTTCATGGG GGATGAGTGG TTTGTGGATT CCCTCAACCA GAAGATGGAG 
GTGCAGCGCC GGCCCTGGTT AGTGAAGTAC GGGGACAGCG GGGAGCAGAT TGCCGGCTTC 
GTGAAGGAGT TCTCCCACAT CGCCTTTCTC ACGATCAAGG GCGCCGGCCA CATGGTTCCC 
ACCGACAAGC CCCTCGCTGC CTTCACCATG TTCTCCCGCT TCCTGAACAA GCAGCCATAC 
TGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

PubMed

Altered mitochondrial expression genes in patients receiving right ventricular apical pacing.
Experimental and molecular pathology100(3)469-75(2016 06)
Xu H,Gao J,Wang F

Lysosomal multienzyme complex: pros and cons of working together.
Cellular and molecular life sciences : CMLS71(11)2017-32(2014 Jun)
Bonten EJ,Annunziata I,d'Azzo A

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CTSA cDNA ORF clone, Homo sapiens(human)

Gene

Clones

gRNAs

Related articles in PubMed

Target ORF information:

Target ORF information:

ORF Insert Sequence:

Target ORF information:

Target ORF information:

ORF Insert Sequence:

Target ORF information:

Target ORF information:

ORF Insert Sequence:

Target ORF information:

Target ORF information:

ORF Insert Sequence:

Target ORF information:

Target ORF information:

ORF Insert Sequence:

Target ORF information:

Target ORF information:

ORF Insert Sequence:

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