UGT1A3 cDNA ORF clone, Homo sapiens(human)

Gene
Clones
gRNAs

Summary

Gene Symbol	UGT1A3
Entrez Gene ID	54659
Full Name	UDP glucuronosyltransferase family 1 member A3
Synonyms	UDPGT,UDPGT 1-3,UGT-1C,UGT1-03,UGT1.3,UGT1A3S,UGT1C
General protein information	Preferred Names UDP glucuronosyltransferase family 1 member A3 Names UDP-glucuronosyltransferase 1-3 UDP glucuronosyltransferase 1 family, polypeptide A3 UDP glycosyltransferase 1 family, polypeptide A3 UDP-glucuronosyltransferase 1 family polypeptide A3s UDP-glucuronosyltransferase 1-C UDP-glucuronosyltransferase 1A3 UGT1*3
Gene Type	protein-coding
Organism	Homo sapiens(human)
Genome	Chromosome: 2 Map Location: 2q37.1
Summary	This gene encodes a UDP-glucuronosyltransferase, an enzyme of the glucuronidation pathway that transforms small lipophilic molecules, such as steroids, bilirubin, hormones, and drugs, into water-soluble, excretable metabolites. This gene is part of a complex locus that encodes several UDP-glucuronosyltransferases. The locus includes thirteen unique alternate first exons followed by four common exons. Four of the alternate first exons are considered pseudogenes. Each of the remaining nine 5' exons may be spliced to the four common exons, resulting in nine proteins with different N-termini and identical C-termini. Each first exon encodes the substrate binding site, and is regulated by its own promoter. Substrates of this enzyme include estrone, 2-hydroxyestrone, and metabolites of benzo alpha-pyrene. [provided by RefSeq, Jul 2008].
Disorder MIM:	606428

mRNA and Protein(s)

mRNA	Protein	Name
NM_019093.2	NP_061966.1	UDP-glucuronosyltransferase 1-3 precursor
NM_019093.4	NP_061966.1	UDP-glucuronosyltransferase 1-3 precursor

Pathways from BioSystems

Homologies

Homo sapiens (human)	UGT1A3	NP_061966.1
Drosophila melanogaster (fruit fly)	Ugt37c1	NP_525007.1
Drosophila melanogaster (fruit fly)	Ugt37a1	NP_523607.1
Drosophila melanogaster (fruit fly)	Ugt36Bc	NP_652627.2
Drosophila melanogaster (fruit fly)	Ugt37b1	NP_525008.2
Drosophila melanogaster (fruit fly)	Ugt36Ba	NP_001260516.1
Anopheles gambiae (African malaria mosquito)	AgaP_AGAP007589	XP_001687884.1
Anopheles gambiae (African malaria mosquito)	AgaP_AGAP007588	XP_308284.4
Mus musculus (house mouse)	Ugt1a2	NP_038729.1
Rattus norvegicus (Norway rat)	Ugt1a2	NP_958826.1
Drosophila melanogaster (fruit fly)	Ugt36Bb	NP_652628.2
Drosophila melanogaster (fruit fly)	CG5999	NP_650229.2
Anopheles gambiae (African malaria mosquito)	AgaP_AGAP011564	XP_309943.4
Drosophila melanogaster (fruit fly)	CG5724	NP_650228.1

Gene Ontology
Bibliography

Related articles in PubMed

Glucuronidation of icaritin by human liver microsomes, human intestine microsomes and expressed UDP-glucuronosyltransferase enzymes: identification of UGT1A3, 1A9 and 2B7 as the main contributing enzymes.
Wang L, Hong X, Yao Z, Dai Y, Zhao G, Qin Z, Wu B, Gonzalez FJ, Yao X
Xenobiotica; the fate of foreign compounds in biological systems1-11(2017 May)

Genome-wide analysis of hepatic lipid content in extreme obesity.
DiStefano JK, Kingsley C, Craig Wood G, Chu X, Argyropoulos G, Still CD, Don? SC, Legendre C, Tembe W, Gerhard GS
Acta diabetologica52(2)373-82(2015 Apr)

Increased UGT1A3 and UGT1A7 expression is associated with pancreatic cancer.
Yilmaz L, Borazan E, Aytekin T, Baskonus I, Aytekin A, Oztuzcu S, Bozdag Z, Balik A
Asian Pacific journal of cancer prevention : APJCP16(4)1651-5(2015)

An atlas of genetic influences on human blood metabolites.
Shin SY, Fauman EB, Petersen AK, Krumsiek J, Santos R, Huang J, Arnold M, Erte I, Forgetta V, Yang TP, Walter K, Menni C, Chen L, Vasquez L, Valdes AM, Hyde CL, Wang V, Ziemek D, Roberts P, Xi L, Grundberg E, , Waldenberger M, Richards JB, Mohney RP, Milburn MV, John SL, Trimmer J, Theis FJ, Overington JP, Suhre K, Brosnan MJ, Gieger C, Kastenm?ller G, Spector TD, Soranzo N
Nature genetics46(6)543-550(2014 Jun)

GeneRIFs: Gene References Into Functions What's a GeneRIF?

Increased UGT1A3 expression is associated with pancreatic cancer.
Title: Increased UGT1A3 and UGT1A7 expression is associated with pancreatic cancer.

Human UGT1A4 and UGT1A3 conjugate 25-hydroxyvitamin D3.
Title: Human UGT1A4 and UGT1A3 conjugate 25-hydroxyvitamin D3: metabolite structure, kinetics, inducibility, and interindividual variability.

the substrate specificity of UGT2B10, highlighting its preference for tertiary amines with higher affinities and clearance values than those of UGT1A4 and UGT1A3.
Title: Human UDP-glucuronosyltransferase (UGT) 2B10 in drug N-glucuronidation: substrate screening and comparison with UGT1A3 and UGT1A4.

Observational study of gene-disease association, gene-environment interaction, and pharmacogenomic / toxicogenomic. (HuGE Navigator)
Title: Variation at the NFATC2 locus increases the risk of thiazolidinedione-induced edema in the Diabetes REduction Assessment with ramipril and rosiglitazone Medication (DREAM) study.

Transcriptional regulation of the human bile acid and xenobiotic UGT1A3 by its substrate CDCA and FXR is shown
Title: Regulation of the human bile acid UDP-glucuronosyltransferase 1A3 by the farnesoid X receptor and bile acids.

The following UGT1A3 gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the UGT1A3 cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1⁺/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.

***CloneID	Accession No.	Definition	**Vector	*Turnaround time	Price (USD)
OHu25065	NM_019093.4 Latest version!	Homo sapiens UDP glucuronosyltransferase family 1 member A3 (UGT1A3), mRNA.	pcDNA3.1-C-(k)DYK or customized vector	in pcDNA3.1-C-(k)DYK	$219.50-$307.30 $439.00
View Old Accession Versions >>
OHu25065	NM_019093.2	Homo sapiens UDP glucuronosyltransferase family 1 member A3 (UGT1A3), mRNA.	pcDNA3.1-C-(k)DYK or customized vector	in pcDNA3.1-C-(k)DYK	$219.50-$307.30 $439.00
Hide Old Accession Versions >>

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** GenScript guarantees 100% sequence accuracy of all synthetic DNA constructs we deliver, but we do not guarantee protein expression in your experimental system. Protein expression is influenced by many factors that may vary between experiments or laboratories. In addition, please pay attention to the signal peptide, propeptide and transit peptide in target ORF, which may affect the choice of vector (N/C terminal tag vector).

***One clone ID might be correlated to multiple accession numbers, which share the same CDS sequence.

Reference Sequences (Refseq)

UGT1A3 ( NM_019093.2 ) cDNA ORF clone, Homo sapiens(human) -> NP_061966.1 Homo sapiens UDP glucuronosyltransferase family 1 member A3 (UGT1A3), mRNA.

Price & Availability↑

CloneID	OHu25065
Clone ID Related Accession (Same CDS sequence)	NM_019093.2 , NM_019093.4
Accession Version	NM_019093.2	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 1605bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-05-03
Organism	Homo sapiens(human)
Product	UDP-glucuronosyltransferase 1-3 precursor
Comment	Comment: REVIEWED REFSEQ: This record has been curated by NCBI staff. The reference sequence was derived from AY435138.1. This sequence is a reference standard in the RefSeqGene project. On Jan 25, 2004 this sequence version replaced NM_019093.1. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: AY435138.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA2145122, SAMN04284274 [ECO:0000348] ##Evidence-Data-END## ##RefSeq-Attributes-START## RefSeq Select criteria :: based on single protein-coding transcript ##RefSeq-Attributes-END## COMPLETENESS: complete on the 3' end.

ATGGCCACAG GACTCCAGGT TCCCCTGCCG TGGCTGGCCA CAGGACTGCT GCTTCTCCTC 
AGTGTCCAGC CCTGGGCTGA GAGTGGAAAG GTGTTGGTGG TGCCCATTGA TGGCAGCCAC 
TGGCTCAGCA TGCGGGAGGT CTTGCGGGAG CTCCATGCCA GAGGCCACCA GGCAGTGGTC 
CTCACCCCAG AGGTGAATAT GCACATCAAA GAAGAGAACT TTTTCACCCT GACAACCTAT 
GCCATTTCGT GGACCCAGGA TGAATTTGAT CGCCATGTGC TGGGCCACAC TCAACTGTAC 
TTTGAAACAG AACATTTTCT GAAGAAATTT TTCAGAAGTA TGGCAATGTT GAACAATATG 
TCTTTGGTCT ATCATAGGTC TTGTGTGGAG CTACTACATA ATGAGGCCCT GATCAGGCAC 
CTGAATGCTA CTTCCTTTGA TGTGGTTTTA ACAGACCCCG TTAACCTCTG CGCGGCAGTG 
CTGGCTAAGT ACCTGTCGAT TCCTACTGTG TTTTTTTTGA GGAACATTCC ATGTGATTTA 
GACTTTAAGG GCACACAGTG TCCAAACCCT TCCTCCTATA TTCCTAGATT ACTAACAACC 
AATTCAGACC ACATGACATT CATGCAAAGG GTCAAGAACA TGCTCTACCC TCTGGCCCTG 
TCCTACATTT GCCATGCTTT TTCTGCTCCT TATGCAAGCC TTGCCTCTGA GCTTTTTCAG 
AGAGAGGTGT CAGTGGTGGA TATTCTCAGT CATGCATCTG TGTGGCTGTT CCGAGGGGAC 
TTTGTGATGG ACTACCCCAG GCCAATCATG CCCAACATGG TCTTCATTGG GGGCATCAAC 
TGTGCCAACA GGAAGCCACT ATCTCAGGAA TTTGAAGCCT ACATTAATGC TTCTGGAGAA 
CATGGAATTG TGGTTTTCTC TTTGGGATCA ATGGTCTCAG AAATTCCAGA GAAGAAAGCT 
ATGGCAATTG CTGATGCTTT GGGCAAAATC CCTCAGACAG TCCTGTGGCG GTACACTGGA 
ACCCGACCAT CGAATCTTGC GAACAACACG ATACTTGTTA AGTGGCTACC CCAAAACGAT 
CTGCTTGGTC ACCCGATGAC CCGTGCCTTT ATCACCCATG CTGGTTCCCA TGGTGTTTAT 
GAAAGCATAT GCAATGGCGT TCCCATGGTG ATGATGCCCT TGTTTGGTGA TCAGATGGAC 
AATGCAAAGC GCATGGAGAC TAAGGGAGCT GGAGTGACCC TGAATGTTCT GGAAATGACT 
TCTGAAGATT TAGAAAATGC TCTAAAAGCA GTCATCAATG ACAAAAGTTA CAAGGAGAAC 
ATCATGCGCC TCTCCAGCCT TCACAAGGAC CGCCCGGTGG AGCCGCTGGA CCTGGCCGTG 
TTCTGGGTGG AGTTTGTGAT GAGGCACAAG GGCGCGCCAC ACCTGCGCCC CGCAGCCCAC 
GACCTCACCT GGTACCAGTA CCATTCCTTG GACGTGATTG GTTTCCTCTT GGCCGTCGTG 
CTGACAGTGG CCTTCATCAC CTTTAAATGT TGTGCTTATG GCTACCGGAA ATGCTTGGGG 
AAAAAAGGGC GAGTTAAGAA AGCCCACAAA TCCAAGACCC ATTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_061966.1
CDS	1..1605
Translation	MATGLQVPLPWLATGLLLLLSVQPWAESGKVLVVPIDGSHWLSMREVLRELHARGHQAVVLTPEVNMHIKEENFFTLTTYAISWTQDEFDRHVLGHTQLYFETEHFLKKFFRSMAMLNNMSLVYHRSCVELLHNEALIRHLNATSFDVVLTDPVNLCAAVLAKYLSIPTVFFLRNIPCDLDFKGTQCPNPSSYIPRLLTTNSDHMTFMQRVKNMLYPLALSYICHAFSAPYASLASELFQREVSVVDILSHASVWLFRGDFVMDYPRPIMPNMVFIGGINCANRKPLSQEFEAYINASGEHGIVVFSLGSMVSEIPEKKAMAIADALGKIPQTVLWRYTGTRPSNLANNTILVKWLPQNDLLGHPMTRAFITHAGSHGVYESICNGVPMVMMPLFGDQMDNAKRMETKGAGVTLNVLEMTSEDLENALKAVINDKSYKENIMRLSSLHKDRPVEPLDLAVFWVEFVMRHKGAPHLRPAAHDLTWYQYHSLDVIGFLLAVVLTVAFITFKCCAYGYRKCLGKKGRVKKAHKSKTH

Target ORF information:

RefSeq Version	NM_019093.2
Organism	Homo sapiens(human)
Definition	Homo sapiens UDP glucuronosyltransferase family 1 member A3 (UGT1A3), mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_019093.2

ORF Insert Sequence:

ATGGCCACAG GACTCCAGGT TCCCCTGCCG TGGCTGGCCA CAGGACTGCT GCTTCTCCTC 
AGTGTCCAGC CCTGGGCTGA GAGTGGAAAG GTGTTGGTGG TGCCCATTGA TGGCAGCCAC 
TGGCTCAGCA TGCGGGAGGT CTTGCGGGAG CTCCATGCCA GAGGCCACCA GGCAGTGGTC 
CTCACCCCAG AGGTGAATAT GCACATCAAA GAAGAGAACT TTTTCACCCT GACAACCTAT 
GCCATTTCGT GGACCCAGGA TGAATTTGAT CGCCATGTGC TGGGCCACAC TCAACTGTAC 
TTTGAAACAG AACATTTTCT GAAGAAATTT TTCAGAAGTA TGGCAATGTT GAACAATATG 
TCTTTGGTCT ATCATAGGTC TTGTGTGGAG CTACTACATA ATGAGGCCCT GATCAGGCAC 
CTGAATGCTA CTTCCTTTGA TGTGGTTTTA ACAGACCCCG TTAACCTCTG CGCGGCAGTG 
CTGGCTAAGT ACCTGTCGAT TCCTACTGTG TTTTTTTTGA GGAACATTCC ATGTGATTTA 
GACTTTAAGG GCACACAGTG TCCAAACCCT TCCTCCTATA TTCCTAGATT ACTAACAACC 
AATTCAGACC ACATGACATT CATGCAAAGG GTCAAGAACA TGCTCTACCC TCTGGCCCTG 
TCCTACATTT GCCATGCTTT TTCTGCTCCT TATGCAAGCC TTGCCTCTGA GCTTTTTCAG 
AGAGAGGTGT CAGTGGTGGA TATTCTCAGT CATGCATCTG TGTGGCTGTT CCGAGGGGAC 
TTTGTGATGG ACTACCCCAG GCCAATCATG CCCAACATGG TCTTCATTGG GGGCATCAAC 
TGTGCCAACA GGAAGCCACT ATCTCAGGAA TTTGAAGCCT ACATTAATGC TTCTGGAGAA 
CATGGAATTG TGGTTTTCTC TTTGGGATCA ATGGTCTCAG AAATTCCAGA GAAGAAAGCT 
ATGGCAATTG CTGATGCTTT GGGCAAAATC CCTCAGACAG TCCTGTGGCG GTACACTGGA 
ACCCGACCAT CGAATCTTGC GAACAACACG ATACTTGTTA AGTGGCTACC CCAAAACGAT 
CTGCTTGGTC ACCCGATGAC CCGTGCCTTT ATCACCCATG CTGGTTCCCA TGGTGTTTAT 
GAAAGCATAT GCAATGGCGT TCCCATGGTG ATGATGCCCT TGTTTGGTGA TCAGATGGAC 
AATGCAAAGC GCATGGAGAC TAAGGGAGCT GGAGTGACCC TGAATGTTCT GGAAATGACT 
TCTGAAGATT TAGAAAATGC TCTAAAAGCA GTCATCAATG ACAAAAGTTA CAAGGAGAAC 
ATCATGCGCC TCTCCAGCCT TCACAAGGAC CGCCCGGTGG AGCCGCTGGA CCTGGCCGTG 
TTCTGGGTGG AGTTTGTGAT GAGGCACAAG GGCGCGCCAC ACCTGCGCCC CGCAGCCCAC 
GACCTCACCT GGTACCAGTA CCATTCCTTG GACGTGATTG GTTTCCTCTT GGCCGTCGTG 
CTGACAGTGG CCTTCATCAC CTTTAAATGT TGTGCTTATG GCTACCGGAA ATGCTTGGGG 
AAAAAAGGGC GAGTTAAGAA AGCCCACAAA TCCAAGACCC ATTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

UGT1A3 ( NM_019093.4 ) cDNA ORF clone, Homo sapiens(human) -> NP_061966.1 Homo sapiens UDP glucuronosyltransferase family 1 member A3 (UGT1A3), mRNA.

Price & Availability↑

CloneID	OHu25065
Clone ID Related Accession (Same CDS sequence)	NM_019093.2 , NM_019093.4
Accession Version	NM_019093.4 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 1605bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2020-01-02
Organism	Homo sapiens(human)
Product	UDP-glucuronosyltransferase 1-3 precursor
Comment	Comment: REVIEWED REFSEQ: This record has been curated by NCBI staff. The reference sequence was derived from AC114812.5 and AC006985.2. On Jan 3, 2020 this sequence version replaced NM_019093.3. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: AY435138.1, SRR5189664.74674.1 [ECO:0000332] ##Evidence-Data-END## ##RefSeq-Attributes-START## RefSeq Select criteria :: based on single protein-coding transcript ##RefSeq-Attributes-END## COMPLETENESS: full length.

ATGGCCACAG GACTCCAGGT TCCCCTGCCG TGGCTGGCCA CAGGACTGCT GCTTCTCCTC 
AGTGTCCAGC CCTGGGCTGA GAGTGGAAAG GTGTTGGTGG TGCCCATTGA TGGCAGCCAC 
TGGCTCAGCA TGCGGGAGGT CTTGCGGGAG CTCCATGCCA GAGGCCACCA GGCAGTGGTC 
CTCACCCCAG AGGTGAATAT GCACATCAAA GAAGAGAACT TTTTCACCCT GACAACCTAT 
GCCATTTCGT GGACCCAGGA TGAATTTGAT CGCCATGTGC TGGGCCACAC TCAACTGTAC 
TTTGAAACAG AACATTTTCT GAAGAAATTT TTCAGAAGTA TGGCAATGTT GAACAATATG 
TCTTTGGTCT ATCATAGGTC TTGTGTGGAG CTACTACATA ATGAGGCCCT GATCAGGCAC 
CTGAATGCTA CTTCCTTTGA TGTGGTTTTA ACAGACCCCG TTAACCTCTG CGCGGCAGTG 
CTGGCTAAGT ACCTGTCGAT TCCTACTGTG TTTTTTTTGA GGAACATTCC ATGTGATTTA 
GACTTTAAGG GCACACAGTG TCCAAACCCT TCCTCCTATA TTCCTAGATT ACTAACAACC 
AATTCAGACC ACATGACATT CATGCAAAGG GTCAAGAACA TGCTCTACCC TCTGGCCCTG 
TCCTACATTT GCCATGCTTT TTCTGCTCCT TATGCAAGCC TTGCCTCTGA GCTTTTTCAG 
AGAGAGGTGT CAGTGGTGGA TATTCTCAGT CATGCATCTG TGTGGCTGTT CCGAGGGGAC 
TTTGTGATGG ACTACCCCAG GCCAATCATG CCCAACATGG TCTTCATTGG GGGCATCAAC 
TGTGCCAACA GGAAGCCACT ATCTCAGGAA TTTGAAGCCT ACATTAATGC TTCTGGAGAA 
CATGGAATTG TGGTTTTCTC TTTGGGATCA ATGGTCTCAG AAATTCCAGA GAAGAAAGCT 
ATGGCAATTG CTGATGCTTT GGGCAAAATC CCTCAGACAG TCCTGTGGCG GTACACTGGA 
ACCCGACCAT CGAATCTTGC GAACAACACG ATACTTGTTA AGTGGCTACC CCAAAACGAT 
CTGCTTGGTC ACCCGATGAC CCGTGCCTTT ATCACCCATG CTGGTTCCCA TGGTGTTTAT 
GAAAGCATAT GCAATGGCGT TCCCATGGTG ATGATGCCCT TGTTTGGTGA TCAGATGGAC 
AATGCAAAGC GCATGGAGAC TAAGGGAGCT GGAGTGACCC TGAATGTTCT GGAAATGACT 
TCTGAAGATT TAGAAAATGC TCTAAAAGCA GTCATCAATG ACAAAAGTTA CAAGGAGAAC 
ATCATGCGCC TCTCCAGCCT TCACAAGGAC CGCCCGGTGG AGCCGCTGGA CCTGGCCGTG 
TTCTGGGTGG AGTTTGTGAT GAGGCACAAG GGCGCGCCAC ACCTGCGCCC CGCAGCCCAC 
GACCTCACCT GGTACCAGTA CCATTCCTTG GACGTGATTG GTTTCCTCTT GGCCGTCGTG 
CTGACAGTGG CCTTCATCAC CTTTAAATGT TGTGCTTATG GCTACCGGAA ATGCTTGGGG 
AAAAAAGGGC GAGTTAAGAA AGCCCACAAA TCCAAGACCC ATTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_061966.1
CDS	86..1690
Translation	MATGLQVPLPWLATGLLLLLSVQPWAESGKVLVVPIDGSHWLSMREVLRELHARGHQAVVLTPEVNMHIKEENFFTLTTYAISWTQDEFDRHVLGHTQLYFETEHFLKKFFRSMAMLNNMSLVYHRSCVELLHNEALIRHLNATSFDVVLTDPVNLCAAVLAKYLSIPTVFFLRNIPCDLDFKGTQCPNPSSYIPRLLTTNSDHMTFMQRVKNMLYPLALSYICHAFSAPYASLASELFQREVSVVDILSHASVWLFRGDFVMDYPRPIMPNMVFIGGINCANRKPLSQEFEAYINASGEHGIVVFSLGSMVSEIPEKKAMAIADALGKIPQTVLWRYTGTRPSNLANNTILVKWLPQNDLLGHPMTRAFITHAGSHGVYESICNGVPMVMMPLFGDQMDNAKRMETKGAGVTLNVLEMTSEDLENALKAVINDKSYKENIMRLSSLHKDRPVEPLDLAVFWVEFVMRHKGAPHLRPAAHDLTWYQYHSLDVIGFLLAVVLTVAFITFKCCAYGYRKCLGKKGRVKKAHKSKTH

Target ORF information:

RefSeq Version	NM_019093.4
Organism	Homo sapiens(human)
Definition	Homo sapiens UDP glucuronosyltransferase family 1 member A3 (UGT1A3), mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_019093.4

ORF Insert Sequence:

ATGGCCACAG GACTCCAGGT TCCCCTGCCG TGGCTGGCCA CAGGACTGCT GCTTCTCCTC 
AGTGTCCAGC CCTGGGCTGA GAGTGGAAAG GTGTTGGTGG TGCCCATTGA TGGCAGCCAC 
TGGCTCAGCA TGCGGGAGGT CTTGCGGGAG CTCCATGCCA GAGGCCACCA GGCAGTGGTC 
CTCACCCCAG AGGTGAATAT GCACATCAAA GAAGAGAACT TTTTCACCCT GACAACCTAT 
GCCATTTCGT GGACCCAGGA TGAATTTGAT CGCCATGTGC TGGGCCACAC TCAACTGTAC 
TTTGAAACAG AACATTTTCT GAAGAAATTT TTCAGAAGTA TGGCAATGTT GAACAATATG 
TCTTTGGTCT ATCATAGGTC TTGTGTGGAG CTACTACATA ATGAGGCCCT GATCAGGCAC 
CTGAATGCTA CTTCCTTTGA TGTGGTTTTA ACAGACCCCG TTAACCTCTG CGCGGCAGTG 
CTGGCTAAGT ACCTGTCGAT TCCTACTGTG TTTTTTTTGA GGAACATTCC ATGTGATTTA 
GACTTTAAGG GCACACAGTG TCCAAACCCT TCCTCCTATA TTCCTAGATT ACTAACAACC 
AATTCAGACC ACATGACATT CATGCAAAGG GTCAAGAACA TGCTCTACCC TCTGGCCCTG 
TCCTACATTT GCCATGCTTT TTCTGCTCCT TATGCAAGCC TTGCCTCTGA GCTTTTTCAG 
AGAGAGGTGT CAGTGGTGGA TATTCTCAGT CATGCATCTG TGTGGCTGTT CCGAGGGGAC 
TTTGTGATGG ACTACCCCAG GCCAATCATG CCCAACATGG TCTTCATTGG GGGCATCAAC 
TGTGCCAACA GGAAGCCACT ATCTCAGGAA TTTGAAGCCT ACATTAATGC TTCTGGAGAA 
CATGGAATTG TGGTTTTCTC TTTGGGATCA ATGGTCTCAG AAATTCCAGA GAAGAAAGCT 
ATGGCAATTG CTGATGCTTT GGGCAAAATC CCTCAGACAG TCCTGTGGCG GTACACTGGA 
ACCCGACCAT CGAATCTTGC GAACAACACG ATACTTGTTA AGTGGCTACC CCAAAACGAT 
CTGCTTGGTC ACCCGATGAC CCGTGCCTTT ATCACCCATG CTGGTTCCCA TGGTGTTTAT 
GAAAGCATAT GCAATGGCGT TCCCATGGTG ATGATGCCCT TGTTTGGTGA TCAGATGGAC 
AATGCAAAGC GCATGGAGAC TAAGGGAGCT GGAGTGACCC TGAATGTTCT GGAAATGACT 
TCTGAAGATT TAGAAAATGC TCTAAAAGCA GTCATCAATG ACAAAAGTTA CAAGGAGAAC 
ATCATGCGCC TCTCCAGCCT TCACAAGGAC CGCCCGGTGG AGCCGCTGGA CCTGGCCGTG 
TTCTGGGTGG AGTTTGTGAT GAGGCACAAG GGCGCGCCAC ACCTGCGCCC CGCAGCCCAC 
GACCTCACCT GGTACCAGTA CCATTCCTTG GACGTGATTG GTTTCCTCTT GGCCGTCGTG 
CTGACAGTGG CCTTCATCAC CTTTAAATGT TGTGCTTATG GCTACCGGAA ATGCTTGGGG 
AAAAAAGGGC GAGTTAAGAA AGCCCACAAA TCCAAGACCC ATTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

PubMed

Glucuronidation of icaritin by human liver microsomes, human intestine microsomes and expressed UDP-glucuronosyltransferase enzymes: identification of UGT1A3, 1A9 and 2B7 as the main contributing enzymes.
Xenobiotica; the fate of foreign compounds in biological systems1-11(2017 May)
Wang L,Hong X,Yao Z,Dai Y,Zhao G,Qin Z,Wu B,Gonzalez FJ,Yao X

Genome-wide analysis of hepatic lipid content in extreme obesity.
Acta diabetologica52(2)373-82(2015 Apr)
DiStefano JK,Kingsley C,Craig Wood G,Chu X,Argyropoulos G,Still CD,Don? SC,Legendre C,Tembe W,Gerhard GS

Increased UGT1A3 and UGT1A7 expression is associated with pancreatic cancer.
Asian Pacific journal of cancer prevention : APJCP16(4)1651-5(2015)
Yilmaz L,Borazan E,Aytekin T,Baskonus I,Aytekin A,Oztuzcu S,Bozdag Z,Balik A

An atlas of genetic influences on human blood metabolites.
Nature genetics46(6)543-550(2014 Jun)
Shin SY,Fauman EB,Petersen AK,Krumsiek J,Santos R,Huang J,Arnold M,Erte I,Forgetta V,Yang TP,Walter K,Menni C,Chen L,Vasquez L,Valdes AM,Hyde CL,Wang V,Ziemek D,Roberts P,Xi L,Grundberg E,,Waldenberger M,Richards JB,Mohney RP,Milburn MV,John SL,Trimmer J,Theis FJ,Overington JP,Suhre K,Brosnan MJ,Gieger C,Kastenm?ller G,Spector TD,Soranzo N

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UGT1A3 cDNA ORF clone, Homo sapiens(human)

Gene

Clones

gRNAs

Related articles in PubMed

Target ORF information:

Target ORF information:

ORF Insert Sequence:

Target ORF information:

Target ORF information:

ORF Insert Sequence:

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