GNB1L cDNA ORF clone, Homo sapiens(human)

Gene
Clones
gRNAs

Summary

Gene Symbol	GNB1L
Entrez Gene ID	54584
Full Name	G protein subunit beta 1 like
Synonyms	DGCRK3,FKSG1,GY2,WDR14,WDVCF
General protein information	Preferred Names G protein subunit beta 1 like Names guanine nucleotide-binding protein subunit beta-like protein 1 G-protein beta subunit-like protein WD repeat-containing protein 14 WD40 repeat-containing protein deleted in VCFS g protein subunit beta-like protein 1 guanine nucleotide binding protein (G protein), beta polypeptide 1-like guanine nucleotide binding protein beta-subunit-like polypeptide
Gene Type	protein-coding
Organism	Homo sapiens(human)
Genome	Chromosome: 22 Map Location: 22q11.21
Summary	This gene encodes a G-protein beta-subunit-like polypeptide which is a member of the WD repeat protein family. WD repeats are minimally conserved regions of approximately 40 amino acids typically bracketed by gly-his and trp-asp (GH-WD), which may facilitate formation of heterotrimeric or multiprotein complexes. Members of this family are involved in a variety of cellular processes, including cell cycle progression, signal transduction, apoptosis, and gene regulation. This protein contains 6 WD repeats and is highly expressed in the heart. The gene maps to the region on chromosome 22q11, which is deleted in DiGeorge syndrome, trisomic in derivative 22 syndrome and tetrasomic in cat-eye syndrome. Therefore, this gene may contribute to the etiology of those disorders. Transcripts from this gene share exons with some transcripts from the C22orf29 gene. [provided by RefSeq, Jul 2008].
Disorder MIM:	610778

mRNA and Protein(s)

mRNA	Protein	Name
NM_053004.2	NP_443730.1	guanine nucleotide-binding protein subunit beta-like protein 1
NM_053004.3	NP_443730.1	guanine nucleotide-binding protein subunit beta-like protein 1

Pathways from BioSystems

Homologies

Mus musculus (house mouse)	Gnb1l	NP_075609.2
Gallus gallus (chicken)	GNB1L	NP_001012811.1
Oryza sativa (rice)	Os06g0131100	NP_001056694.1
Canis lupus familiaris (dog)	GNB1L	XP_543544.4
Arabidopsis thaliana (thale cress)	EMB2757	NP_194715.2
Drosophila melanogaster (fruit fly)	CG13192	NP_610702.1
Bos taurus (cattle)	GNB1L	NP_001179269.1
Homo sapiens (human)	GNB1L	NP_443730.1
Rattus norvegicus (Norway rat)	Gnb1l	XP_006248712.1
Danio rerio (zebrafish)	gnb1l	NP_001013526.1
Anopheles gambiae (African malaria mosquito)	AgaP_AGAP011814	XP_320701.2
Xenopus tropicalis (tropical clawed frog)	gnb1l	NP_001120042.1

Gene Ontology
Bibliography

Related articles in PubMed

The schizophrenia/bipolar disorder candidate gene GNB1L is regulated in human temporal cortex by a cis-acting element located within the 3'-region.
Sun Y, Tao Y, Wang J, Saffen D
Neuroscience bulletin31(1)43-52(2015 Feb)

Association study between GNB1L and three major mental disorders in Chinese Han populations.
Li Y, Zhao Q, Wang T, Liu J, Li J, Li T, Zeng Z, Feng G, He L, Shi Y
Psychiatry research187(3)457-9(2011 May)

?-blocker therapy and heart rate control during exercise testing in the general population: role of a common G-protein ?-3 subunit variant.
D?rr M, Schmidt CO, Spielhagen T, Bornhorst A, Hentschel K, Franz C, Empen K, Kocher T, Diehl SR, Kroemer HK, V?lzke H, Ewert R, Felix SB, Rosskopf D
Pharmacogenomics11(9)1209-21(2010 Sep)

Supportive evidence for reduced expression of GNB1L in schizophrenia.
Ishiguro H, Koga M, Horiuchi Y, Noguchi E, Morikawa M, Suzuki Y, Arai M, Niizato K, Iritani S, Itokawa M, Inada T, Iwata N, Ozaki N, Ujike H, Kunugi H, Sasaki T, Takahashi M, Watanabe Y, Someya T, Kakita A, Takahashi H, Nawa H, Arinami T
Schizophrenia bulletin36(4)756-65(2010 Jul)

GbetaL regulates TNFalpha-induced NF-kappaB signaling by directly inhibiting the activation of IkappaB kinase.
Kim YL, Kim JE, Shin KJ, Lee S, Ahn C, Chung J, Kim DH, Seong JY, Hwang JI
Cellular signalling20(11)2127-33(2008 Nov)

GeneRIFs: Gene References Into Functions What's a GeneRIF?

mRNA expression results implies that the GNB1L high-expression allele is the risk allele for schizophrenia and bipolar disorder in the Han Chinese population.
Title: The schizophrenia/bipolar disorder candidate gene GNB1L is regulated in human temporal cortex by a cis-acting element located within the 3'-region.

Observational study of gene-disease association. (HuGE Navigator)
Title: Association study between GNB1L and three major mental disorders in Chinese Han populations.

Beta-blocker therapy and heart rate control during exercise testing in the general population: role of GNB1L variant.
Title: ?-blocker therapy and heart rate control during exercise testing in the general population: role of a common G-protein ?-3 subunit variant.

The present findings support assertions that GNB1L is one of the genes in the 22q11DS region responsible for increasing the risk of schizophrenia.
Title: Supportive evidence for reduced expression of GNB1L in schizophrenia.

GbetaL is involved in the negative regulation of TNFalpha-stimulated NF-kappaB signaling through a direct interaction with IKK.
Title: GbetaL regulates TNFalpha-induced NF-kappaB signaling by directly inhibiting the activation of IkappaB kinase.

The following GNB1L gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the GNB1L cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1⁺/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.

***CloneID	Accession No.	Definition	**Vector	*Turnaround time	Price (USD)
OHu05623	NM_053004.3 Latest version!	Homo sapiens G protein subunit beta 1 like (GNB1L), mRNA.	pcDNA3.1-C-(k)DYK or customized vector	in pcDNA3.1-C-(k)DYK	$99.50-$139.30 $199.00
View Old Accession Versions >>
OHu05623	NM_053004.2	Homo sapiens G protein subunit beta 1 like (GNB1L), mRNA.	pcDNA3.1-C-(k)DYK or customized vector	in pcDNA3.1-C-(k)DYK	$99.50-$139.30 $199.00
Hide Old Accession Versions >>

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** GenScript guarantees 100% sequence accuracy of all synthetic DNA constructs we deliver, but we do not guarantee protein expression in your experimental system. Protein expression is influenced by many factors that may vary between experiments or laboratories. In addition, please pay attention to the signal peptide, propeptide and transit peptide in target ORF, which may affect the choice of vector (N/C terminal tag vector).

***One clone ID might be correlated to multiple accession numbers, which share the same CDS sequence.

Reference Sequences (Refseq)

GNB1L ( NM_053004.2 ) cDNA ORF clone, Homo sapiens(human) -> NP_443730.1 Homo sapiens G protein subunit beta 1 like (GNB1L), mRNA.

Price & Availability↑

CloneID	OHu05623
Clone ID Related Accession (Same CDS sequence)	NM_053004.2 , NM_053004.3
Accession Version	NM_053004.2	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 984bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2017-10-01
Organism	Homo sapiens(human)
Product	guanine nucleotide-binding protein subunit beta-like protein 1
Comment	Comment: VALIDATED REFSEQ: This record has undergone validation or preliminary review. The reference sequence was derived from AY007378.1 and CA425124.1. On Feb 24, 2007 this sequence version replaced NM_053004.1. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: AY007378.1, AF301895.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA1965299, SAMEA1968189 [ECO:0000348] ##Evidence-Data-END## COMPLETENESS: full length.

ATGACGGCCC CCTGCCCGCC GCCACCTCCA GACCCCCAGT TTGTCCTCCG AGGCACCCAG 
TCACCGGTGC ATGCGCTGCA CTTCTGCGAA GGAGCCCAGG CTCAGGGGCG CCCGCTCCTC 
TTCTCAGGGT CTCAGAGTGG CCTGGTACAC ATCTGGAGCC TGCAGACGCG GAGAGCGGTT 
ACCACCCTGG ATGGCCACGG CGGCCAGTGT GTGACCTGGC TGCAGACGCT GCCCCAGGGG 
CGCCAGCTCC TCAGTCAGGG CCGGGACCTG AAGCTGTGCC TGTGGGACCT CGCGGAGGGC 
AGGAGCGCTG TCGTGGACTC CGTGTGCTTG GAGAGTGTGG GCTTCTGCCG GAGCAGCATC 
CTGGCCGGGG GCCAGCCACG CTGGACGCTT GCCGTGCCAG GGAGGGGCAG CGACGAGGTT 
CAGATTCTGG AGATGCCCTC CAAGACGTCA GTGTGCGCCC TGAAGCCGAA GGCAGATGCC 
AAGCTGGGCA TGCCCATGTG CCTGCGGCTG TGGCAGGCCG ACTGCAGCTC CCGCCCACTC 
CTTCTGGCCG GCTATGAGGA TGGATCGGTG GTCCTGTGGG ACGTCTCTGA GCAGAAGGTG 
TGCAGCCGCA TCGCCTGCCA TGAGGAGCCC GTCATGGACC TTGACTTTGA CTCCCAGAAG 
GCCAGGGGCA TCTCAGGCTC CGCGGGGAAG GCGCTGGCTG TCTGGAGCCT GGACTGGCAG 
CAGGCCCTGC AGGTGCGTGG GACTCATGAA CTCACCAATC CCGGGATCGC CGAGGTCACG 
ATCCGGCCAG ATCGCAAGAT CCTGGCCACC GCAGGCTGGG ACCACCGCAT CCGCGTGTTC 
CACTGGCGGA CGATGCAGCC ACTGGCCGTG CTGGCCTTCC ACAGCGCCGC TGTCCAGTGC 
GTGGCCTTCA CCGCCGATGG CTTGCTGGCC GCGGGCTCCA AGGATCAGCG GATCAGCCTC 
TGGTCACTCT ACCCACGCGC ATGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_443730.1
CDS	238..1221
Translation	MTAPCPPPPPDPQFVLRGTQSPVHALHFCEGAQAQGRPLLFSGSQSGLVHIWSLQTRRAVTTLDGHGGQCVTWLQTLPQGRQLLSQGRDLKLCLWDLAEGRSAVVDSVCLESVGFCRSSILAGGQPRWTLAVPGRGSDEVQILEMPSKTSVCALKPKADAKLGMPMCLRLWQADCSSRPLLLAGYEDGSVVLWDVSEQKVCSRIACHEEPVMDLDFDSQKARGISGSAGKALAVWSLDWQQALQVRGTHELTNPGIAEVTIRPDRKILATAGWDHRIRVFHWRTMQPLAVLAFHSAAVQCVAFTADGLLAAGSKDQRISLWSLYPRA

Target ORF information:

RefSeq Version	NM_053004.2
Organism	Homo sapiens(human)
Definition	Homo sapiens G protein subunit beta 1 like (GNB1L), mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_053004.2

ORF Insert Sequence:

ATGACGGCCC CCTGCCCGCC GCCACCTCCA GACCCCCAGT TTGTCCTCCG AGGCACCCAG 
TCACCGGTGC ATGCGCTGCA CTTCTGCGAA GGAGCCCAGG CTCAGGGGCG CCCGCTCCTC 
TTCTCAGGGT CTCAGAGTGG CCTGGTACAC ATCTGGAGCC TGCAGACGCG GAGAGCGGTT 
ACCACCCTGG ATGGCCACGG CGGCCAGTGT GTGACCTGGC TGCAGACGCT GCCCCAGGGG 
CGCCAGCTCC TCAGTCAGGG CCGGGACCTG AAGCTGTGCC TGTGGGACCT CGCGGAGGGC 
AGGAGCGCTG TCGTGGACTC CGTGTGCTTG GAGAGTGTGG GCTTCTGCCG GAGCAGCATC 
CTGGCCGGGG GCCAGCCACG CTGGACGCTT GCCGTGCCAG GGAGGGGCAG CGACGAGGTT 
CAGATTCTGG AGATGCCCTC CAAGACGTCA GTGTGCGCCC TGAAGCCGAA GGCAGATGCC 
AAGCTGGGCA TGCCCATGTG CCTGCGGCTG TGGCAGGCCG ACTGCAGCTC CCGCCCACTC 
CTTCTGGCCG GCTATGAGGA TGGATCGGTG GTCCTGTGGG ACGTCTCTGA GCAGAAGGTG 
TGCAGCCGCA TCGCCTGCCA TGAGGAGCCC GTCATGGACC TTGACTTTGA CTCCCAGAAG 
GCCAGGGGCA TCTCAGGCTC CGCGGGGAAG GCGCTGGCTG TCTGGAGCCT GGACTGGCAG 
CAGGCCCTGC AGGTGCGTGG GACTCATGAA CTCACCAATC CCGGGATCGC CGAGGTCACG 
ATCCGGCCAG ATCGCAAGAT CCTGGCCACC GCAGGCTGGG ACCACCGCAT CCGCGTGTTC 
CACTGGCGGA CGATGCAGCC ACTGGCCGTG CTGGCCTTCC ACAGCGCCGC TGTCCAGTGC 
GTGGCCTTCA CCGCCGATGG CTTGCTGGCC GCGGGCTCCA AGGATCAGCG GATCAGCCTC 
TGGTCACTCT ACCCACGCGC ATGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

GNB1L ( NM_053004.3 ) cDNA ORF clone, Homo sapiens(human) -> NP_443730.1 Homo sapiens G protein subunit beta 1 like (GNB1L), mRNA.

Price & Availability↑

CloneID	OHu05623
Clone ID Related Accession (Same CDS sequence)	NM_053004.2 , NM_053004.3
Accession Version	NM_053004.3 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 984bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-08-02
Organism	Homo sapiens(human)
Product	guanine nucleotide-binding protein subunit beta-like protein 1
Comment	Comment: VALIDATED REFSEQ: This record has undergone validation or preliminary review. The reference sequence was derived from AY007378.1, CA425124.1, AC000089.1 and AC000091.1. On Nov 22, 2018 this sequence version replaced NM_053004.2. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: AF301895.1, AY007378.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA1965299, SAMEA1968189 [ECO:0000348] ##Evidence-Data-END## ##RefSeq-Attributes-START## MANE Ensembl match :: ENST00000329517.11/ ENSP00000331313.6 RefSeq Select criteria :: based on single protein-coding transcript ##RefSeq-Attributes-END## COMPLETENESS: full length.

ATGACGGCCC CCTGCCCGCC GCCACCTCCA GACCCCCAGT TTGTCCTCCG AGGCACCCAG 
TCACCGGTGC ATGCGCTGCA CTTCTGCGAA GGAGCCCAGG CTCAGGGGCG CCCGCTCCTC 
TTCTCAGGGT CTCAGAGTGG CCTGGTACAC ATCTGGAGCC TGCAGACGCG GAGAGCGGTT 
ACCACCCTGG ATGGCCACGG CGGCCAGTGT GTGACCTGGC TGCAGACGCT GCCCCAGGGG 
CGCCAGCTCC TCAGTCAGGG CCGGGACCTG AAGCTGTGCC TGTGGGACCT CGCGGAGGGC 
AGGAGCGCTG TCGTGGACTC CGTGTGCTTG GAGAGTGTGG GCTTCTGCCG GAGCAGCATC 
CTGGCCGGGG GCCAGCCACG CTGGACGCTT GCCGTGCCAG GGAGGGGCAG CGACGAGGTT 
CAGATTCTGG AGATGCCCTC CAAGACGTCA GTGTGCGCCC TGAAGCCGAA GGCAGATGCC 
AAGCTGGGCA TGCCCATGTG CCTGCGGCTG TGGCAGGCCG ACTGCAGCTC CCGCCCACTC 
CTTCTGGCCG GCTATGAGGA TGGATCGGTG GTCCTGTGGG ACGTCTCTGA GCAGAAGGTG 
TGCAGCCGCA TCGCCTGCCA TGAGGAGCCC GTCATGGACC TTGACTTTGA CTCCCAGAAG 
GCCAGGGGCA TCTCAGGCTC CGCGGGGAAG GCGCTGGCTG TCTGGAGCCT GGACTGGCAG 
CAGGCCCTGC AGGTGCGTGG GACTCATGAA CTCACCAATC CCGGGATCGC CGAGGTCACG 
ATCCGGCCAG ATCGCAAGAT CCTGGCCACC GCAGGCTGGG ACCACCGCAT CCGCGTGTTC 
CACTGGCGGA CGATGCAGCC ACTGGCCGTG CTGGCCTTCC ACAGCGCCGC TGTCCAGTGC 
GTGGCCTTCA CCGCCGATGG CTTGCTGGCC GCGGGCTCCA AGGATCAGCG GATCAGCCTC 
TGGTCACTCT ACCCACGCGC ATGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_443730.1
CDS	173..1156
Translation	MTAPCPPPPPDPQFVLRGTQSPVHALHFCEGAQAQGRPLLFSGSQSGLVHIWSLQTRRAVTTLDGHGGQCVTWLQTLPQGRQLLSQGRDLKLCLWDLAEGRSAVVDSVCLESVGFCRSSILAGGQPRWTLAVPGRGSDEVQILEMPSKTSVCALKPKADAKLGMPMCLRLWQADCSSRPLLLAGYEDGSVVLWDVSEQKVCSRIACHEEPVMDLDFDSQKARGISGSAGKALAVWSLDWQQALQVRGTHELTNPGIAEVTIRPDRKILATAGWDHRIRVFHWRTMQPLAVLAFHSAAVQCVAFTADGLLAAGSKDQRISLWSLYPRA

Target ORF information:

RefSeq Version	NM_053004.3
Organism	Homo sapiens(human)
Definition	Homo sapiens G protein subunit beta 1 like (GNB1L), mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_053004.3

ORF Insert Sequence:

ATGACGGCCC CCTGCCCGCC GCCACCTCCA GACCCCCAGT TTGTCCTCCG AGGCACCCAG 
TCACCGGTGC ATGCGCTGCA CTTCTGCGAA GGAGCCCAGG CTCAGGGGCG CCCGCTCCTC 
TTCTCAGGGT CTCAGAGTGG CCTGGTACAC ATCTGGAGCC TGCAGACGCG GAGAGCGGTT 
ACCACCCTGG ATGGCCACGG CGGCCAGTGT GTGACCTGGC TGCAGACGCT GCCCCAGGGG 
CGCCAGCTCC TCAGTCAGGG CCGGGACCTG AAGCTGTGCC TGTGGGACCT CGCGGAGGGC 
AGGAGCGCTG TCGTGGACTC CGTGTGCTTG GAGAGTGTGG GCTTCTGCCG GAGCAGCATC 
CTGGCCGGGG GCCAGCCACG CTGGACGCTT GCCGTGCCAG GGAGGGGCAG CGACGAGGTT 
CAGATTCTGG AGATGCCCTC CAAGACGTCA GTGTGCGCCC TGAAGCCGAA GGCAGATGCC 
AAGCTGGGCA TGCCCATGTG CCTGCGGCTG TGGCAGGCCG ACTGCAGCTC CCGCCCACTC 
CTTCTGGCCG GCTATGAGGA TGGATCGGTG GTCCTGTGGG ACGTCTCTGA GCAGAAGGTG 
TGCAGCCGCA TCGCCTGCCA TGAGGAGCCC GTCATGGACC TTGACTTTGA CTCCCAGAAG 
GCCAGGGGCA TCTCAGGCTC CGCGGGGAAG GCGCTGGCTG TCTGGAGCCT GGACTGGCAG 
CAGGCCCTGC AGGTGCGTGG GACTCATGAA CTCACCAATC CCGGGATCGC CGAGGTCACG 
ATCCGGCCAG ATCGCAAGAT CCTGGCCACC GCAGGCTGGG ACCACCGCAT CCGCGTGTTC 
CACTGGCGGA CGATGCAGCC ACTGGCCGTG CTGGCCTTCC ACAGCGCCGC TGTCCAGTGC 
GTGGCCTTCA CCGCCGATGG CTTGCTGGCC GCGGGCTCCA AGGATCAGCG GATCAGCCTC 
TGGTCACTCT ACCCACGCGC ATGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

PubMed

The schizophrenia/bipolar disorder candidate gene GNB1L is regulated in human temporal cortex by a cis-acting element located within the 3'-region.
Neuroscience bulletin31(1)43-52(2015 Feb)
Sun Y,Tao Y,Wang J,Saffen D

Association study between GNB1L and three major mental disorders in Chinese Han populations.
Psychiatry research187(3)457-9(2011 May)
Li Y,Zhao Q,Wang T,Liu J,Li J,Li T,Zeng Z,Feng G,He L,Shi Y

?-blocker therapy and heart rate control during exercise testing in the general population: role of a common G-protein ?-3 subunit variant.
Pharmacogenomics11(9)1209-21(2010 Sep)
D?rr M,Schmidt CO,Spielhagen T,Bornhorst A,Hentschel K,Franz C,Empen K,Kocher T,Diehl SR,Kroemer HK,V?lzke H,Ewert R,Felix SB,Rosskopf D

Supportive evidence for reduced expression of GNB1L in schizophrenia.
Schizophrenia bulletin36(4)756-65(2010 Jul)
Ishiguro H,Koga M,Horiuchi Y,Noguchi E,Morikawa M,Suzuki Y,Arai M,Niizato K,Iritani S,Itokawa M,Inada T,Iwata N,Ozaki N,Ujike H,Kunugi H,Sasaki T,Takahashi M,Watanabe Y,Someya T,Kakita A,Takahashi H,Nawa H,Arinami T

GbetaL regulates TNFalpha-induced NF-kappaB signaling by directly inhibiting the activation of IkappaB kinase.
Cellular signalling20(11)2127-33(2008 Nov)
Kim YL,Kim JE,Shin KJ,Lee S,Ahn C,Chung J,Kim DH,Seong JY,Hwang JI

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GNB1L cDNA ORF clone, Homo sapiens(human)

Gene

Clones

gRNAs

Related articles in PubMed

Target ORF information:

Target ORF information:

ORF Insert Sequence:

Target ORF information:

Target ORF information:

ORF Insert Sequence:

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