POU3F4 cDNA ORF clone, Homo sapiens(human)

Gene
Clones
gRNAs

Summary

Gene Symbol	POU3F4
Entrez Gene ID	5456
Full Name	POU class 3 homeobox 4
Synonyms	BRAIN-4,BRN-4,BRN4,DFN3,DFNX2,OCT-9,OTF-9,OTF9
General protein information	Preferred Names POU class 3 homeobox 4 Names POU domain, class 3, transcription factor 4 brain-specific homeobox/POU domain protein 4 octamer-binding transcription factor 9
Gene Type	protein-coding
Organism	Homo sapiens(human)
Genome	Chromosome: X Map Location: Xq21.1
Summary	This gene encodes a member of the POU-III class of neural transcription factors. This family member plays a role in inner ear development. The protein is thought to be involved in the mediation of epigenetic signals which induce striatal neuron-precursor differentiation. Mutations in this gene are associated with X chromosome-linked nonsyndromic mixed deafness. [provided by RefSeq, Dec 2012].
Disorder MIM:	300039
Disorder Html:	Deafness, X-linked 2, 304400 (3)

mRNA and Protein(s)

mRNA	Protein	Name
NM_000307.4	NP_000298.3	POU domain, class 3, transcription factor 4
NM_000307.5	NP_000298.3	POU domain, class 3, transcription factor 4

Pathways from BioSystems

Homologies

Pan troglodytes (chimpanzee)	POU3F4	XP_003317585.1
	POU3F4	XP_001104059.1
Canis lupus familiaris (dog)	POU3F4	XP_549108.1
Mus musculus (house mouse)	Pou3f4	NP_032927.1
Rattus norvegicus (Norway rat)	Pou3f4	NP_058948.1
Homo sapiens (human)	POU3F4	NP_000298.3
Bos taurus (cattle)	POU3F4	XP_002699986.1
Xenopus tropicalis (tropical clawed frog)	pou3f4	NP_001090728.1

Gene Ontology
Bibliography

Related articles in PubMed

Frequency and specific characteristics of the incomplete partition type III anomaly in children.
Kanno A, Mutai H, Namba K, Morita N, Nakano A, Ogahara N, Sugiuchi T, Ogawa K, Matsunaga T
The Laryngoscope127(7)1663-1669(2017 Jul)

A
Du W, Han MK, Wang DY, Han B, Zong L, Lan L, Yang J, Shen Q, Xie LY, Yu L, Guan J, Wang QJ
Chinese medical journal130(1)88-92(2017 01)

Clinical observations and molecular variables of patients with hearing loss and incomplete partition type III.
Choi BY, An YH, Song JJ, Koo JW, Lee JH, Oh SH, Chang SO, Kim CS, Park JH
The Laryngoscope126(3)E123-8(2016 Mar)

Novel and De Novo Mutations Extend Association of POU3F4 with Distinct Clinical and Radiological Phenotype of Hearing Loss.
Pollak A, Lechowicz U, K?dra A, Stawi?ski P, Rydzanicz M, Furmanek M, Brzozowska M, Mr?wka M, Skar?y?ski H, Skar?y?ski PH, O?dak M, P?oski R
PloS one11(12)e0166618(2016)

GeneRIFs: Gene References Into Functions What's a GeneRIF?

POU3F4 mutations can be predicted by incomplete partition type III anomaly by radiological examination of the inner ear. All six of the patients showed mixed hearing loss, but none showed fluctuations in hearing, which may be related to the lack of vestibular aqueduct enlargement at the operculum.
Title: Frequency and specific characteristics of the incomplete partition type III anomaly in children.

A nonsense mutation is identified in a family displaying the pedigree consistent with X-linked recessive pattern in POU3F4 gene.
Title: A

POU3F4 mutation in profoundly deaf patients may have poorer prognosis after cochlear implantation, than other types.
Title: Clinical observations and molecular variables of patients with hearing loss and incomplete partition type III.

Sequencing of the entire POU3F4 gene is recommended in patients with characteristic temporal bone malformations. Results of POU3F4 mutation testing are important not only for a proper genetic counseling, but also for adequate preparation and conduction of a surgical procedure.
Title: Novel and De Novo Mutations Extend Association of POU3F4 with Distinct Clinical and Radiological Phenotype of Hearing Loss.

findings may greatly contribute to the elucidation of the roles of the Oct and Myc proteins in osteoblast direct reprogramming. The results may also lead to establishment of novel regenerative therapy for various bone resorption diseases
Title: Transduction of Oct6 or Oct9 gene concomitant with Myc family gene induced osteoblast-like phenotypic conversion in normal human fibroblasts.

The following POU3F4 gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the POU3F4 cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1⁺/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.

***CloneID	Accession No.	Definition	**Vector	*Turnaround time	Price (USD)
OHu20520	NM_000307.5 Latest version!	Homo sapiens POU class 3 homeobox 4 (POU3F4), mRNA.	pcDNA3.1-C-(k)DYK or customized vector	in pcDNA3.1-C-(k)DYK	$149.50-$209.30 $299.00
View Old Accession Versions >>
OHu20520	NM_000307.4	Homo sapiens POU class 3 homeobox 4 (POU3F4), mRNA.	pcDNA3.1-C-(k)DYK or customized vector	in pcDNA3.1-C-(k)DYK	$149.50-$209.30 $299.00
Hide Old Accession Versions >>

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** GenScript guarantees 100% sequence accuracy of all synthetic DNA constructs we deliver, but we do not guarantee protein expression in your experimental system. Protein expression is influenced by many factors that may vary between experiments or laboratories. In addition, please pay attention to the signal peptide, propeptide and transit peptide in target ORF, which may affect the choice of vector (N/C terminal tag vector).

***One clone ID might be correlated to multiple accession numbers, which share the same CDS sequence.

Reference Sequences (Refseq)

POU3F4 ( NM_000307.4 ) cDNA ORF clone, Homo sapiens(human) -> NP_000298.3 Homo sapiens POU class 3 homeobox 4 (POU3F4), mRNA.

Price & Availability↑

CloneID	OHu20520
Clone ID Related Accession (Same CDS sequence)	NM_000307.4 , NM_000307.5
Accession Version	NM_000307.4	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 1086bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-02-22
Organism	Homo sapiens(human)
Product	POU domain, class 3, transcription factor 4
Comment	Comment: REVIEWED REFSEQ: This record has been curated by NCBI staff. The reference sequence was derived from AK314967.1, Z82170.3 and X82324.1. This sequence is a reference standard in the RefSeqGene project. On Dec 26, 2012 this sequence version replaced NM_000307.3. Sequence Note: This RefSeq record was created from transcript and genomic sequence data to make the sequence consistent with the reference genome assembly. The genomic coordinates used for the transcript record were based on transcript alignments. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications.

ATGGCCACAG CTGCCTCGAA TCCCTACAGC ATTCTCAGTT CCACCTCCCT AGTCCATGCG 
GACTCTGCGG GCATGCAGCA GGGGAGTCCT TTCCGCAACC CTCAGAAACT TCTCCAAAGT 
GATTACTTGC AGGGAGTTCC CAGCAATGGG CATCCCCTCG GGCATCACTG GGTGACCAGT 
CTGAGCGACG GGGGCCCATG GTCCTCCACA CTGGCCACCA GCCCCCTGGA CCAGCAGGAC 
GTGAAGCCCG GGCGCGAAGA CCTGCAACTG GGTGCGATCA TCCATCACCG CTCGCCACAC 
GTAGCCCACC ACTCACCGCA CACTAACCAC CCCAACGCCT GGGGGGCCAG CCCGGCACCG 
AACCCGTCTA TCACGTCAAG CGGCCAACCC CTCAACGTGT ACTCGCAGCC TGGCTTCACC 
GTGAGCGGCA TGCTGGAACA CGGGGGACTC ACCCCACCTC CAGCTGCCGC CTCTGCACAG 
AGCCTGCACC CGGTGCTCCG AGAGCCCCCG GATCACGGCG AACTGGGCTC GCACCATTGC 
CAGGATCACT CCGACGAGGA GACGCCAACC TCTGATGAGT TGGAACAGTT CGCCAAACAA 
TTCAAACAAA GAAGAATCAA GTTGGGCTTC ACGCAGGCCG ACGTGGGGTT GGCGCTGGGC 
ACACTGTATG GTAACGTGTT CTCGCAGACC ACCATCTGCA GGTTCGAGGC CTTGCAGCTG 
AGCTTCAAAA ATATGTGCAA GCTGAAGCCC CTGCTGAACA AGTGGCTGGA GGAGGCGGAT 
TCGTCCACAG GGAGCCCGAC CAGCATTGAC AAGATCGCTG CACAGGGCCG CAAGCGCAAG 
AAGCGGACCT CCATCGAGGT GAGTGTCAAG GGCGTACTGG AGACGCATTT CCTCAAGTGT 
CCCAAGCCTG CCGCGCAGGA GATCTCCTCG CTGGCAGACA GCCTCCAGTT GGAGAAGGAA 
GTGGTGCGTG TCTGGTTCTG TAATCGAAGA CAAAAAGAGA AAAGAATGAC TCCGCCAGGG 
GATCAGCAGC CGCATGAGGT TTATTCGCAC ACCGTGAAAA CAGACACATC TTGCCATGAT 
CTCTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_000298.3
CDS	65..1150
Translation	MATAASNPYSILSSTSLVHADSAGMQQGSPFRNPQKLLQSDYLQGVPSNGHPLGHHWVTSLSDGGPWSSTLATSPLDQQDVKPGREDLQLGAIIHHRSPHVAHHSPHTNHPNAWGASPAPNPSITSSGQPLNVYSQPGFTVSGMLEHGGLTPPPAAASAQSLHPVLREPPDHGELGSHHCQDHSDEETPTSDELEQFAKQFKQRRIKLGFTQADVGLALGTLYGNVFSQTTICRFEALQLSFKNMCKLKPLLNKWLEEADSSTGSPTSIDKIAAQGRKRKKRTSIEVSVKGVLETHFLKCPKPAAQEISSLADSLQLEKEVVRVWFCNRRQKEKRMTPPGDQQPHEVYSHTVKTDTSCHDL

Target ORF information:

RefSeq Version	NM_000307.4
Organism	Homo sapiens(human)
Definition	Homo sapiens POU class 3 homeobox 4 (POU3F4), mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_000307.4

ORF Insert Sequence:

ATGGCCACAG CTGCCTCGAA TCCCTACAGC ATTCTCAGTT CCACCTCCCT AGTCCATGCG 
GACTCTGCGG GCATGCAGCA GGGGAGTCCT TTCCGCAACC CTCAGAAACT TCTCCAAAGT 
GATTACTTGC AGGGAGTTCC CAGCAATGGG CATCCCCTCG GGCATCACTG GGTGACCAGT 
CTGAGCGACG GGGGCCCATG GTCCTCCACA CTGGCCACCA GCCCCCTGGA CCAGCAGGAC 
GTGAAGCCCG GGCGCGAAGA CCTGCAACTG GGTGCGATCA TCCATCACCG CTCGCCACAC 
GTAGCCCACC ACTCACCGCA CACTAACCAC CCCAACGCCT GGGGGGCCAG CCCGGCACCG 
AACCCGTCTA TCACGTCAAG CGGCCAACCC CTCAACGTGT ACTCGCAGCC TGGCTTCACC 
GTGAGCGGCA TGCTGGAACA CGGGGGACTC ACCCCACCTC CAGCTGCCGC CTCTGCACAG 
AGCCTGCACC CGGTGCTCCG AGAGCCCCCG GATCACGGCG AACTGGGCTC GCACCATTGC 
CAGGATCACT CCGACGAGGA GACGCCAACC TCTGATGAGT TGGAACAGTT CGCCAAACAA 
TTCAAACAAA GAAGAATCAA GTTGGGCTTC ACGCAGGCCG ACGTGGGGTT GGCGCTGGGC 
ACACTGTATG GTAACGTGTT CTCGCAGACC ACCATCTGCA GGTTCGAGGC CTTGCAGCTG 
AGCTTCAAAA ATATGTGCAA GCTGAAGCCC CTGCTGAACA AGTGGCTGGA GGAGGCGGAT 
TCGTCCACAG GGAGCCCGAC CAGCATTGAC AAGATCGCTG CACAGGGCCG CAAGCGCAAG 
AAGCGGACCT CCATCGAGGT GAGTGTCAAG GGCGTACTGG AGACGCATTT CCTCAAGTGT 
CCCAAGCCTG CCGCGCAGGA GATCTCCTCG CTGGCAGACA GCCTCCAGTT GGAGAAGGAA 
GTGGTGCGTG TCTGGTTCTG TAATCGAAGA CAAAAAGAGA AAAGAATGAC TCCGCCAGGG 
GATCAGCAGC CGCATGAGGT TTATTCGCAC ACCGTGAAAA CAGACACATC TTGCCATGAT 
CTCTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

POU3F4 ( NM_000307.5 ) cDNA ORF clone, Homo sapiens(human) -> NP_000298.3 Homo sapiens POU class 3 homeobox 4 (POU3F4), mRNA.

Price & Availability↑

CloneID	OHu20520
Clone ID Related Accession (Same CDS sequence)	NM_000307.4 , NM_000307.5
Accession Version	NM_000307.5 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 1086bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-09-27
Organism	Homo sapiens(human)
Product	POU domain, class 3, transcription factor 4
Comment	Comment: REVIEWED REFSEQ: This record has been curated by NCBI staff. The reference sequence was derived from AK314967.1, Z82170.3 and X82324.1. This sequence is a reference standard in the RefSeqGene project. On May 17, 2019 this sequence version replaced NM_000307.4. Sequence Note: This RefSeq record was created from transcript and genomic sequence data to make the sequence consistent with the reference genome assembly. The genomic coordinates used for the transcript record were based on transcript alignments. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript is intronless :: X82324.1, AK314967.1 [ECO:0000345] ##Evidence-Data-END## ##RefSeq-Attributes-START## MANE Ensembl match :: ENST00000644024.2/ ENSP00000495996.1 RefSeq Select criteria :: based on single protein-coding transcript ##RefSeq-Attributes-END##

ATGGCCACAG CTGCCTCGAA TCCCTACAGC ATTCTCAGTT CCACCTCCCT AGTCCATGCG 
GACTCTGCGG GCATGCAGCA GGGGAGTCCT TTCCGCAACC CTCAGAAACT TCTCCAAAGT 
GATTACTTGC AGGGAGTTCC CAGCAATGGG CATCCCCTCG GGCATCACTG GGTGACCAGT 
CTGAGCGACG GGGGCCCATG GTCCTCCACA CTGGCCACCA GCCCCCTGGA CCAGCAGGAC 
GTGAAGCCCG GGCGCGAAGA CCTGCAACTG GGTGCGATCA TCCATCACCG CTCGCCACAC 
GTAGCCCACC ACTCACCGCA CACTAACCAC CCCAACGCCT GGGGGGCCAG CCCGGCACCG 
AACCCGTCTA TCACGTCAAG CGGCCAACCC CTCAACGTGT ACTCGCAGCC TGGCTTCACC 
GTGAGCGGCA TGCTGGAACA CGGGGGACTC ACCCCACCTC CAGCTGCCGC CTCTGCACAG 
AGCCTGCACC CGGTGCTCCG AGAGCCCCCG GATCACGGCG AACTGGGCTC GCACCATTGC 
CAGGATCACT CCGACGAGGA GACGCCAACC TCTGATGAGT TGGAACAGTT CGCCAAACAA 
TTCAAACAAA GAAGAATCAA GTTGGGCTTC ACGCAGGCCG ACGTGGGGTT GGCGCTGGGC 
ACACTGTATG GTAACGTGTT CTCGCAGACC ACCATCTGCA GGTTCGAGGC CTTGCAGCTG 
AGCTTCAAAA ATATGTGCAA GCTGAAGCCC CTGCTGAACA AGTGGCTGGA GGAGGCGGAT 
TCGTCCACAG GGAGCCCGAC CAGCATTGAC AAGATCGCTG CACAGGGCCG CAAGCGCAAG 
AAGCGGACCT CCATCGAGGT GAGTGTCAAG GGCGTACTGG AGACGCATTT CCTCAAGTGT 
CCCAAGCCTG CCGCGCAGGA GATCTCCTCG CTGGCAGACA GCCTCCAGTT GGAGAAGGAA 
GTGGTGCGTG TCTGGTTCTG TAATCGAAGA CAAAAAGAGA AAAGAATGAC TCCGCCAGGG 
GATCAGCAGC CGCATGAGGT TTATTCGCAC ACCGTGAAAA CAGACACATC TTGCCATGAT 
CTCTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_000298.3
CDS	36..1121
Translation	MATAASNPYSILSSTSLVHADSAGMQQGSPFRNPQKLLQSDYLQGVPSNGHPLGHHWVTSLSDGGPWSSTLATSPLDQQDVKPGREDLQLGAIIHHRSPHVAHHSPHTNHPNAWGASPAPNPSITSSGQPLNVYSQPGFTVSGMLEHGGLTPPPAAASAQSLHPVLREPPDHGELGSHHCQDHSDEETPTSDELEQFAKQFKQRRIKLGFTQADVGLALGTLYGNVFSQTTICRFEALQLSFKNMCKLKPLLNKWLEEADSSTGSPTSIDKIAAQGRKRKKRTSIEVSVKGVLETHFLKCPKPAAQEISSLADSLQLEKEVVRVWFCNRRQKEKRMTPPGDQQPHEVYSHTVKTDTSCHDL

Target ORF information:

RefSeq Version	NM_000307.5
Organism	Homo sapiens(human)
Definition	Homo sapiens POU class 3 homeobox 4 (POU3F4), mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_000307.5

ORF Insert Sequence:

ATGGCCACAG CTGCCTCGAA TCCCTACAGC ATTCTCAGTT CCACCTCCCT AGTCCATGCG 
GACTCTGCGG GCATGCAGCA GGGGAGTCCT TTCCGCAACC CTCAGAAACT TCTCCAAAGT 
GATTACTTGC AGGGAGTTCC CAGCAATGGG CATCCCCTCG GGCATCACTG GGTGACCAGT 
CTGAGCGACG GGGGCCCATG GTCCTCCACA CTGGCCACCA GCCCCCTGGA CCAGCAGGAC 
GTGAAGCCCG GGCGCGAAGA CCTGCAACTG GGTGCGATCA TCCATCACCG CTCGCCACAC 
GTAGCCCACC ACTCACCGCA CACTAACCAC CCCAACGCCT GGGGGGCCAG CCCGGCACCG 
AACCCGTCTA TCACGTCAAG CGGCCAACCC CTCAACGTGT ACTCGCAGCC TGGCTTCACC 
GTGAGCGGCA TGCTGGAACA CGGGGGACTC ACCCCACCTC CAGCTGCCGC CTCTGCACAG 
AGCCTGCACC CGGTGCTCCG AGAGCCCCCG GATCACGGCG AACTGGGCTC GCACCATTGC 
CAGGATCACT CCGACGAGGA GACGCCAACC TCTGATGAGT TGGAACAGTT CGCCAAACAA 
TTCAAACAAA GAAGAATCAA GTTGGGCTTC ACGCAGGCCG ACGTGGGGTT GGCGCTGGGC 
ACACTGTATG GTAACGTGTT CTCGCAGACC ACCATCTGCA GGTTCGAGGC CTTGCAGCTG 
AGCTTCAAAA ATATGTGCAA GCTGAAGCCC CTGCTGAACA AGTGGCTGGA GGAGGCGGAT 
TCGTCCACAG GGAGCCCGAC CAGCATTGAC AAGATCGCTG CACAGGGCCG CAAGCGCAAG 
AAGCGGACCT CCATCGAGGT GAGTGTCAAG GGCGTACTGG AGACGCATTT CCTCAAGTGT 
CCCAAGCCTG CCGCGCAGGA GATCTCCTCG CTGGCAGACA GCCTCCAGTT GGAGAAGGAA 
GTGGTGCGTG TCTGGTTCTG TAATCGAAGA CAAAAAGAGA AAAGAATGAC TCCGCCAGGG 
GATCAGCAGC CGCATGAGGT TTATTCGCAC ACCGTGAAAA CAGACACATC TTGCCATGAT 
CTCTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

PubMed

Frequency and specific characteristics of the incomplete partition type III anomaly in children.
The Laryngoscope127(7)1663-1669(2017 Jul)
Kanno A,Mutai H,Namba K,Morita N,Nakano A,Ogahara N,Sugiuchi T,Ogawa K,Matsunaga T

A
Chinese medical journal130(1)88-92(2017 01)
Du W,Han MK,Wang DY,Han B,Zong L,Lan L,Yang J,Shen Q,Xie LY,Yu L,Guan J,Wang QJ

Clinical observations and molecular variables of patients with hearing loss and incomplete partition type III.
The Laryngoscope126(3)E123-8(2016 Mar)
Choi BY,An YH,Song JJ,Koo JW,Lee JH,Oh SH,Chang SO,Kim CS,Park JH

Novel and De Novo Mutations Extend Association of POU3F4 with Distinct Clinical and Radiological Phenotype of Hearing Loss.
PloS one11(12)e0166618(2016)
Pollak A,Lechowicz U,K?dra A,Stawi?ski P,Rydzanicz M,Furmanek M,Brzozowska M,Mr?wka M,Skar?y?ski H,Skar?y?ski PH,O?dak M,P?oski R

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POU3F4 cDNA ORF clone, Homo sapiens(human)

Gene

Clones

gRNAs

Related articles in PubMed

Target ORF information:

Target ORF information:

ORF Insert Sequence:

Target ORF information:

Target ORF information:

ORF Insert Sequence:

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