CYTL1 cDNA ORF clone, Homo sapiens(human)

Gene
Clones
gRNAs

Summary

Gene Symbol	CYTL1
Entrez Gene ID	54360
Full Name	cytokine like 1
Synonyms	C17,C4orf4
General protein information	Preferred Names cytokine like 1 Names cytokine-like protein 1 cytokine-like protein C17
Gene Type	protein-coding
Organism	Homo sapiens(human)
Genome	Chromosome: 4 Map Location: 4p16.2
Summary	C17 is a cytokine-like protein specifically expressed in bone marrow and cord blood mononuclear cells that bear the CD34 (MIM 142230) surface marker (Liu et al., 2000 [PubMed 10857752]).[supplied by OMIM, Mar 2008].
Disorder MIM:	607930

mRNA and Protein(s)

mRNA	Protein	Name
NM_018659.2	NP_061129.1	cytokine-like protein 1 precursor
NM_018659.3	NP_061129.1	cytokine-like protein 1 precursor
XM_017008299.1	XP_016863788.1	cytokine-like protein 1 isoform X1

Pathways from BioSystems

Homologies

Homo sapiens (human)	CYTL1	NP_061129.1
Bos taurus (cattle)	CYTL1	XP_002688471.1
Pan troglodytes (chimpanzee)	CYTL1	XP_001155365.1
Canis lupus familiaris (dog)	CYTL1	XP_853874.1
Gallus gallus (chicken)	CYTL1	XP_420795.1
Xenopus tropicalis (tropical clawed frog)	cytl1	XP_002939091.1
	CYTL1	XP_001094538.1
Mus musculus (house mouse)	Cytl1	NP_001074575.1
Rattus norvegicus (Norway rat)	Cytl1	NP_001128076.1

Gene Ontology
Bibliography

Related articles in PubMed

Biochemical and biophysical characterization of cytokine-like protein 1 (CYTL1).
Tomczak A, Singh K, Gittis AG, Lee J, Garboczi DN, Murphy PM
Cytokine96238-246(2017 Aug)

Cytokine-like 1 Chemoattracts Monocytes/Macrophages via CCR2.
Wang X, Li T, Wang W, Yuan W, Liu H, Cheng Y, Wang P, Zhang Y, Han W
Journal of immunology (Baltimore, Md. : 1950)196(10)4090-9(2016 05)

Efficient production of CYTL1 protein using mouse IgG? signal peptide in the CHO cell expression system.
Wang X, Liu H, Yuan W, Cheng Y, Han W
Acta biochimica et biophysica Sinica48(4)391-4(2016 Apr)

GeneRIFs: Gene References Into Functions What's a GeneRIF?

this study shows that CYTL1 possesses chemotactic activity and demonstrates that its functional receptor is CCR2B
Title: Cytokine-like 1 Chemoattracts Monocytes/Macrophages via CCR2.

when the native signal peptide of CYTL1 was replaced by IgGkappaSP, the expression and secretion was increased by 4 fold.
Title: Efficient production of CYTL1 protein using mouse IgG? signal peptide in the CHO cell expression system.

Cytl1 is highly expressed in the endometrium during the embryo implantation and its expression is regulated by ovarian hormones. Cytl1 enhances endometrial proliferation, induces the secretion of endometrial LIF and HB-EGF, and even enhances endometrial cell adhesion to trophoblastic cells. These indicate that Cytl1 is a potential molecular mediator of embryo is a potential molecular mediator in embryo implantation.
Title: Cytokine-Like Protein 1(Cytl1): A Potential Molecular Mediator in Embryo Implantation.

our results showed the first evidence of CYTL1 expression in SH-SY5Y neuroblastoma cells and human NB tissues, revealed a possible link between CYTL1 and NB development
Title: Cytokine-like 1 is involved in the growth and metastasis of neuroblastoma cells.

evidence suggests that ANKRD7 and CYTL1 genes may play an important role in the variance in alcohol drinking risk
Title: ANKRD7 and CYTL1 are novel risk genes for alcohol drinking behavior.

The following CYTL1 gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the CYTL1 cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1⁺/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.

***CloneID	Accession No.	Definition	**Vector	*Turnaround time	Price (USD)
OHu02380	NM_018659.3 Latest version!	Homo sapiens cytokine like 1 (CYTL1), mRNA.	pcDNA3.1-C-(k)DYK or customized vector	in pcDNA3.1-C-(k)DYK	$49.50-$69.30 $99.00
OHu95236	XM_017008299.1 Latest version!	Homo sapiens cytokine like 1 (CYTL1), transcript variant X1, mRNA.	pcDNA3.1-C-(k)DYK or customized vector	9-11	$69.30 $99.00
View Old Accession Versions >>
OHu02380	NM_018659.2	Homo sapiens cytokine like 1 (CYTL1), mRNA.	pcDNA3.1-C-(k)DYK or customized vector	in pcDNA3.1-C-(k)DYK	$49.50-$69.30 $99.00
Hide Old Accession Versions >>

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** GenScript guarantees 100% sequence accuracy of all synthetic DNA constructs we deliver, but we do not guarantee protein expression in your experimental system. Protein expression is influenced by many factors that may vary between experiments or laboratories. In addition, please pay attention to the signal peptide, propeptide and transit peptide in target ORF, which may affect the choice of vector (N/C terminal tag vector).

***One clone ID might be correlated to multiple accession numbers, which share the same CDS sequence.

Reference Sequences (Refseq)

CYTL1 ( NM_018659.2 ) cDNA ORF clone, Homo sapiens(human) -> NP_061129.1 Homo sapiens cytokine like 1 (CYTL1), mRNA.

Price & Availability↑

CloneID	OHu02380
Clone ID Related Accession (Same CDS sequence)	NM_018659.2 , NM_018659.3
Accession Version	NM_018659.2	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 411bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2017-11-25
Organism	Homo sapiens(human)
Product	cytokine-like protein 1 precursor
Comment	Comment: VALIDATED REFSEQ: This record has undergone validation or preliminary review. The reference sequence was derived from AY359101.1, T83161.1 and BC031391.1. On Jun 30, 2004 this sequence version replaced NM_018659.1. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: BC031391.1, AF193766.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA2149398 [ECO:0000348] ##Evidence-Data-END## COMPLETENESS: complete on the 3' end.

ATGAGGACGC CTGGGCCTCT GCCCGTGCTG CTGCTGCTCC TGGCGGGAGC CCCCGCCGCG 
CGGCCCACTC CCCCGACCTG CTACTCCCGC ATGCGGGCCC TGAGCCAGGA GATCACCCGC 
GACTTCAACC TCCTGCAGGT CTCGGAGCCC TCGGAGCCAT GTGTGAGATA CCTGCCCAGG 
CTGTACCTGG ACATACACAA TTACTGTGTG CTGGACAAGC TGCGGGACTT TGTGGCCTCG 
CCCCCGTGTT GGAAAGTGGC CCAGGTAGAT TCCTTGAAGG ACAAAGCACG GAAGCTGTAC 
ACCATCATGA ACTCGTTCTG CAGGAGAGAT TTGGTATTCC TGTTGGATGA CTGCAATGCC 
TTGGAATACC CAATCCCAGT GACTACGGTC CTGCCAGATC GTCAGCGCTA A

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_061129.1
CDS	26..436
Translation	MRTPGPLPVLLLLLAGAPAARPTPPTCYSRMRALSQEITRDFNLLQVSEPSEPCVRYLPRLYLDIHNYCVLDKLRDFVASPPCWKVAQVDSLKDKARKLYTIMNSFCRRDLVFLLDDCNALEYPIPVTTVLPDRQR

Target ORF information:

RefSeq Version	NM_018659.2
Organism	Homo sapiens(human)
Definition	Homo sapiens cytokine like 1 (CYTL1), mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_018659.2

ORF Insert Sequence:

ATGAGGACGC CTGGGCCTCT GCCCGTGCTG CTGCTGCTCC TGGCGGGAGC CCCCGCCGCG 
CGGCCCACTC CCCCGACCTG CTACTCCCGC ATGCGGGCCC TGAGCCAGGA GATCACCCGC 
GACTTCAACC TCCTGCAGGT CTCGGAGCCC TCGGAGCCAT GTGTGAGATA CCTGCCCAGG 
CTGTACCTGG ACATACACAA TTACTGTGTG CTGGACAAGC TGCGGGACTT TGTGGCCTCG 
CCCCCGTGTT GGAAAGTGGC CCAGGTAGAT TCCTTGAAGG ACAAAGCACG GAAGCTGTAC 
ACCATCATGA ACTCGTTCTG CAGGAGAGAT TTGGTATTCC TGTTGGATGA CTGCAATGCC 
TTGGAATACC CAATCCCAGT GACTACGGTC CTGCCAGATC GTCAGCGCTA A

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

CYTL1 ( NM_018659.3 ) cDNA ORF clone, Homo sapiens(human) -> NP_061129.1 Homo sapiens cytokine like 1 (CYTL1), mRNA.

Price & Availability↑

CloneID	OHu02380
Clone ID Related Accession (Same CDS sequence)	NM_018659.2 , NM_018659.3
Accession Version	NM_018659.3 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 411bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-11-25
Organism	Homo sapiens(human)
Product	cytokine-like protein 1 precursor
Comment	Comment: VALIDATED REFSEQ: This record has undergone validation or preliminary review. The reference sequence was derived from AC108139.5. On Nov 23, 2018 this sequence version replaced NM_018659.2. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: BC031391.1, AF193766.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA2149398 [ECO:0000348] ##Evidence-Data-END## ##RefSeq-Attributes-START## MANE Ensembl match :: ENST00000307746.9/ ENSP00000303550.4 RefSeq Select criteria :: based on conservation, expression ##RefSeq-Attributes-END## COMPLETENESS: full length.

ATGAGGACGC CTGGGCCTCT GCCCGTGCTG CTGCTGCTCC TGGCGGGAGC CCCCGCCGCG 
CGGCCCACTC CCCCGACCTG CTACTCCCGC ATGCGGGCCC TGAGCCAGGA GATCACCCGC 
GACTTCAACC TCCTGCAGGT CTCGGAGCCC TCGGAGCCAT GTGTGAGATA CCTGCCCAGG 
CTGTACCTGG ACATACACAA TTACTGTGTG CTGGACAAGC TGCGGGACTT TGTGGCCTCG 
CCCCCGTGTT GGAAAGTGGC CCAGGTAGAT TCCTTGAAGG ACAAAGCACG GAAGCTGTAC 
ACCATCATGA ACTCGTTCTG CAGGAGAGAT TTGGTATTCC TGTTGGATGA CTGCAATGCC 
TTGGAATACC CAATCCCAGT GACTACGGTC CTGCCAGATC GTCAGCGCTA A

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_061129.1
CDS	14..424
Translation	MRTPGPLPVLLLLLAGAPAARPTPPTCYSRMRALSQEITRDFNLLQVSEPSEPCVRYLPRLYLDIHNYCVLDKLRDFVASPPCWKVAQVDSLKDKARKLYTIMNSFCRRDLVFLLDDCNALEYPIPVTTVLPDRQR

Target ORF information:

RefSeq Version	NM_018659.3
Organism	Homo sapiens(human)
Definition	Homo sapiens cytokine like 1 (CYTL1), mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_018659.3

ORF Insert Sequence:

ATGAGGACGC CTGGGCCTCT GCCCGTGCTG CTGCTGCTCC TGGCGGGAGC CCCCGCCGCG 
CGGCCCACTC CCCCGACCTG CTACTCCCGC ATGCGGGCCC TGAGCCAGGA GATCACCCGC 
GACTTCAACC TCCTGCAGGT CTCGGAGCCC TCGGAGCCAT GTGTGAGATA CCTGCCCAGG 
CTGTACCTGG ACATACACAA TTACTGTGTG CTGGACAAGC TGCGGGACTT TGTGGCCTCG 
CCCCCGTGTT GGAAAGTGGC CCAGGTAGAT TCCTTGAAGG ACAAAGCACG GAAGCTGTAC 
ACCATCATGA ACTCGTTCTG CAGGAGAGAT TTGGTATTCC TGTTGGATGA CTGCAATGCC 
TTGGAATACC CAATCCCAGT GACTACGGTC CTGCCAGATC GTCAGCGCTA A

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

CYTL1 ( XM_017008299.1 ) cDNA ORF clone, Homo sapiens(human) -> XP_016863788.1 Homo sapiens cytokine like 1 (CYTL1), transcript variant X1, mRNA.

Price & Availability↑

CloneID	OHu95236
Clone ID Related Accession (Same CDS sequence)	XM_017008299.1
Accession Version	XM_017008299.1 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 465bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-12-05
Organism	Homo sapiens(human)
Product	cytokine-like protein 1 isoform X1
Comment	Comment: MODEL REFSEQ: This record is predicted by automated computational analysis. This record is derived from a genomic sequence (NC_000004.12) annotated using gene prediction method: Gnomon, supported by EST evidence. Also see: Documentation of NCBI's Annotation Process ##Genome-Annotation-Data-START## Annotation Provider :: NCBI Annotation Status :: Updated annotation Annotation Name :: Homo sapiens Updated Annotation Release 109.20191205 Annotation Version :: 109.20191205 Annotation Pipeline :: NCBI eukaryotic genome annotation pipeline Annotation Software Version :: 8.3 Annotation Method :: Best-placed RefSeq; propagated RefSeq model Features Annotated :: Gene; mRNA; CDS; ncRNA ##Genome-Annotation-Data-END##

ATGAGGACGC CTGGGCCTCT GCCCGTGCTG CTGCTGCTCC TGGCGGGAGC CCCCGCCGCG 
CGGCCCACTC CCCCGACCTG CTACTCCCGC ATGCGGGCCC TGAGCCAGGA GATCACCCGC 
GACTTCAACC TCCTGCAGGT CTCGGAGCCC TCGTTGGAAA ATAAAGTACA AAGAAGAAAA 
AAAATCTTGC TTGTAATTCT ACCACCTAGA GGTAGCTGCT GCCGTAGCAT TGTGGAGGAT 
CATATTTCAG CTTTCTGTCT ACATATAGGA GCCATGTGTG AGATACCTGC CCAGGCTGTA 
CCTGGACATA CACAATTACT GTGTGCTGGA CAAGCTGCGG GACTTTGTGG CCTCGCCCCC 
GTGTTGGAAA GTGGCCCAGG TAGATTCCTT GAAGGACAAA GCACGGAAGC TGTACACCAT 
CATGAACTCG TTCTGCAGGA GAGATTTGGT ATTCCTGTTG GATGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	XP_016863788.1
CDS	26..490
Translation	MRTPGPLPVLLLLLAGAPAARPTPPTCYSRMRALSQEITRDFNLLQVSEPSLENKVQRRKKILLVILPPRGSCCRSIVEDHISAFCLHIGAMCEIPAQAVPGHTQLLCAGQAAGLCGLAPVLESGPGRFLEGQSTEAVHHHELVLQERFGIPVG

Target ORF information:

RefSeq Version	XM_017008299.1
Organism	Homo sapiens(human)
Definition	Homo sapiens cytokine like 1 (CYTL1), transcript variant X1, mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

XM_017008299.1

ORF Insert Sequence:

ATGAGGACGC CTGGGCCTCT GCCCGTGCTG CTGCTGCTCC TGGCGGGAGC CCCCGCCGCG 
CGGCCCACTC CCCCGACCTG CTACTCCCGC ATGCGGGCCC TGAGCCAGGA GATCACCCGC 
GACTTCAACC TCCTGCAGGT CTCGGAGCCC TCGTTGGAAA ATAAAGTACA AAGAAGAAAA 
AAAATCTTGC TTGTAATTCT ACCACCTAGA GGTAGCTGCT GCCGTAGCAT TGTGGAGGAT 
CATATTTCAG CTTTCTGTCT ACATATAGGA GCCATGTGTG AGATACCTGC CCAGGCTGTA 
CCTGGACATA CACAATTACT GTGTGCTGGA CAAGCTGCGG GACTTTGTGG CCTCGCCCCC 
GTGTTGGAAA GTGGCCCAGG TAGATTCCTT GAAGGACAAA GCACGGAAGC TGTACACCAT 
CATGAACTCG TTCTGCAGGA GAGATTTGGT ATTCCTGTTG GATGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

PubMed

Biochemical and biophysical characterization of cytokine-like protein 1 (CYTL1).
Cytokine96238-246(2017 Aug)
Tomczak A,Singh K,Gittis AG,Lee J,Garboczi DN,Murphy PM

Cytokine-like 1 Chemoattracts Monocytes/Macrophages via CCR2.
Journal of immunology (Baltimore, Md. : 1950)196(10)4090-9(2016 05)
Wang X,Li T,Wang W,Yuan W,Liu H,Cheng Y,Wang P,Zhang Y,Han W

Efficient production of CYTL1 protein using mouse IgG? signal peptide in the CHO cell expression system.
Acta biochimica et biophysica Sinica48(4)391-4(2016 Apr)
Wang X,Liu H,Yuan W,Cheng Y,Han W

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CYTL1 cDNA ORF clone, Homo sapiens(human)

Gene

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gRNAs

Related articles in PubMed

Target ORF information:

Target ORF information:

ORF Insert Sequence:

Target ORF information:

Target ORF information:

ORF Insert Sequence:

Target ORF information:

Target ORF information:

ORF Insert Sequence:

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