FXYD7 cDNA ORF clone, Homo sapiens(human)

Gene
Clones
gRNAs

Summary

Gene Symbol	FXYD7
Entrez Gene ID	53822
Full Name	FXYD domain containing ion transport regulator 7
General protein information	Preferred Names FXYD domain containing ion transport regulator 7 Names FXYD domain-containing ion transport regulator 7
Gene Type	protein-coding
Organism	Homo sapiens(human)
Genome	Chromosome: 19 Map Location: 19q13.12
Summary	This reference sequence was derived from multiple replicate ESTs and validated by similar human genomic sequence. This gene encodes a member of a family of small membrane proteins that share a 35-amino acid signature sequence domain, beginning with the sequence PFXYD and containing 7 invariant and 6 highly conserved amino acids. The approved human gene nomenclature for the family is FXYD-domain containing ion transport regulator. Transmembrane topology has been established for two family members (FXYD1 and FXYD2), with the N-terminus extracellular and the C-terminus on the cytoplasmic side of the membrane. FXYD2, also known as the gamma subunit of the Na,K-ATPase, regulates the properties of that enzyme. FXYD1 (phospholemman), FXYD2 (gamma), FXYD3 (MAT-8), FXYD4 (CHIF), and FXYD5 (RIC) have been shown to induce channel activity in experimental expression systems. This gene product, FXYD7, is novel and has not been characterized as a protein. [RefSeq curation by Kathleen J. Sweadner, Ph.D., sweadner@helix.mgh.harvard.edu., Dec 2000].
Disorder MIM:	606684

mRNA and Protein(s)

mRNA	Protein	Name
NM_022006.2	NP_071289.1	FXYD domain-containing ion transport regulator 7
NM_022006.1	NP_071289.1	FXYD domain-containing ion transport regulator 7

Pathways from BioSystems

Homologies

Homo sapiens (human)	FXYD7	NP_071289.1
	LOC718457	XP_001111156.2
Bos taurus (cattle)	FXYD7	NP_001032716.1
Rattus norvegicus (Norway rat)	Fxyd7	NP_071291.1
Mus musculus (house mouse)	Fxyd7	NP_071290.1

Gene Ontology
Bibliography

Related articles in PubMed

Intracellular trafficking of FXYD1 (phospholemman) and FXYD7 proteins in Xenopus oocytes and mammalian cells.
Moshitzky S, Asher C, Garty H
The Journal of biological chemistry287(25)21130-41(2012 Jun)

Variation at the NFATC2 locus increases the risk of thiazolidinedione-induced edema in the Diabetes REduction Assessment with ramipril and rosiglitazone Medication (DREAM) study.
Bailey SD, Xie C, Do R, Montpetit A, Diaz R, Mohan V, Keavney B, Yusuf S, Gerstein HC, Engert JC, Anand S,
Diabetes care33(10)2250-3(2010 Oct)

Gene-centric association signals for lipids and apolipoproteins identified via the HumanCVD BeadChip.
Talmud PJ, Drenos F, Shah S, Shah T, Palmen J, Verzilli C, Gaunt TR, Pallas J, Lovering R, Li K, Casas JP, Sofat R, Kumari M, Rodriguez S, Johnson T, Newhouse SJ, Dominiczak A, Samani NJ, Caulfield M, Sever P, Stanton A, Shields DC, Padmanabhan S, Melander O, Hastie C, Delles C, Ebrahim S, Marmot MG, Smith GD, Lawlor DA, Munroe PB, Day IN, Kivimaki M, Whittaker J, Humphries SE, Hingorani AD, , ,
American journal of human genetics85(5)628-42(2009 Nov)

FXYD7 is a brain-specific regulator of Na,K-ATPase alpha 1-beta isozymes.
B?guin P, Crambert G, Monnet-Tschudi F, Uldry M, Horisberger JD, Garty H, Geering K
The EMBO journal21(13)3264-73(2002 Jul)

The FXYD gene family of small ion transport regulators or channels: cDNA sequence, protein signature sequence, and expression.
Sweadner KJ, Rael E
Genomics68(1)41-56(2000 Aug)

GeneRIFs: Gene References Into Functions What's a GeneRIF?

Intracellular trafficking of FXYD1 (phospholemman) and FXYD7 proteins in Xenopus oocytes and mammalian cells.
Title: Intracellular trafficking of FXYD1 (phospholemman) and FXYD7 proteins in Xenopus oocytes and mammalian cells.

Observational study of gene-disease association, gene-environment interaction, and pharmacogenomic / toxicogenomic. (HuGE Navigator)
Title: Variation at the NFATC2 locus increases the risk of thiazolidinedione-induced edema in the Diabetes REduction Assessment with ramipril and rosiglitazone Medication (DREAM) study.

Observational study of gene-disease association. (HuGE Navigator)
Title: Gene-centric association signals for lipids and apolipoproteins identified via the HumanCVD BeadChip.

The following FXYD7 gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the FXYD7 cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1⁺/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.

***CloneID	Accession No.	Definition	**Vector	*Turnaround time	Price (USD)
OHu03776	NM_022006.2 Latest version!	Homo sapiens FXYD domain containing ion transport regulator 7 (FXYD7), mRNA.	pcDNA3.1-C-(k)DYK or customized vector	in pcDNA3.1-C-(k)DYK	$49.50-$69.30 $99.00
View Old Accession Versions >>
OHu03776	NM_022006.1	Homo sapiens FXYD domain containing ion transport regulator 7 (FXYD7), mRNA.	pcDNA3.1-C-(k)DYK or customized vector	in pcDNA3.1-C-(k)DYK	$49.50-$69.30 $99.00
Hide Old Accession Versions >>

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** GenScript guarantees 100% sequence accuracy of all synthetic DNA constructs we deliver, but we do not guarantee protein expression in your experimental system. Protein expression is influenced by many factors that may vary between experiments or laboratories. In addition, please pay attention to the signal peptide, propeptide and transit peptide in target ORF, which may affect the choice of vector (N/C terminal tag vector).

***One clone ID might be correlated to multiple accession numbers, which share the same CDS sequence.

Reference Sequences (Refseq)

FXYD7 ( NM_022006.2 ) cDNA ORF clone, Homo sapiens(human) -> NP_071289.1 Homo sapiens FXYD domain containing ion transport regulator 7 (FXYD7), mRNA.

Price & Availability↑

CloneID	OHu03776
Clone ID Related Accession (Same CDS sequence)	NM_022006.2 , NM_022006.1
Accession Version	NM_022006.2 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 243bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2020-01-04
Organism	Homo sapiens(human)
Product	FXYD domain-containing ion transport regulator 7
Comment	Comment: REVIEWED REFSEQ: This record has been curated by NCBI staff in collaboration with Kathleen Sweadner. The reference sequence was derived from AC020907.6. On Jun 2, 2019 this sequence version replaced NM_022006.1. ##Evidence-Data-START## Transcript exon combination :: BC018619.1, SRR7410570.653308.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA1966682, SAMEA1968968 [ECO:0000348] ##Evidence-Data-END## ##RefSeq-Attributes-START## RefSeq Select criteria :: based on single protein-coding transcript ##RefSeq-Attributes-END## COMPLETENESS: complete on the 3' end.

ATGGCGACCC CGACCCAGAC CCCCACAAAG GCTCCTGAGG AACCTGACCC ATTTTACTAT 
GACTACAACA CGGTGCAGAC TGTGGGCATG ACTCTGGCAA CCATCTTGTT CCTGCTGGGT 
ATCCTCATCG TCATCAGCAA GAAGGTGAAG TGCAGGAAGG CGGACTCCAG GTCTGAGAGC 
CCAACCTGCA AATCCTGTAA GTCTGAGCTT CCCTCTTCAG CCCCTGGTGG CGGCGGCGTG 
TAA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_071289.1
CDS	80..322
Translation	MATPTQTPTKAPEEPDPFYYDYNTVQTVGMTLATILFLLGILIVISKKVKCRKADSRSESPTCKSCKSELPSSAPGGGGV

Target ORF information:

RefSeq Version	NM_022006.2
Organism	Homo sapiens(human)
Definition	Homo sapiens FXYD domain containing ion transport regulator 7 (FXYD7), mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_022006.2

ORF Insert Sequence:

ATGGCGACCC CGACCCAGAC CCCCACAAAG GCTCCTGAGG AACCTGACCC ATTTTACTAT 
GACTACAACA CGGTGCAGAC TGTGGGCATG ACTCTGGCAA CCATCTTGTT CCTGCTGGGT 
ATCCTCATCG TCATCAGCAA GAAGGTGAAG TGCAGGAAGG CGGACTCCAG GTCTGAGAGC 
CCAACCTGCA AATCCTGTAA GTCTGAGCTT CCCTCTTCAG CCCCTGGTGG CGGCGGCGTG 
TAA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

FXYD7 ( NM_022006.1 ) cDNA ORF clone, Homo sapiens(human) -> NP_071289.1 Homo sapiens FXYD domain containing ion transport regulator 7 (FXYD7), mRNA.

Price & Availability↑

CloneID	OHu03776
Clone ID Related Accession (Same CDS sequence)	NM_022006.2 , NM_022006.1
Accession Version	NM_022006.1	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 243bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-02-15
Organism	Homo sapiens(human)
Product	FXYD domain-containing ion transport regulator 7
Comment	Comment: REVIEWED REFSEQ: This record has been curated by NCBI staff in collaboration with Kathleen Sweadner. The reference sequence was derived from AI929519.1. ##Evidence-Data-START## Transcript exon combination :: BC018619.1, AK057825.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA1966682, SAMEA1968968 [ECO:0000348] ##Evidence-Data-END## COMPLETENESS: complete on the 3' end.

ATGGCGACCC CGACCCAGAC CCCCACAAAG GCTCCTGAGG AACCTGACCC ATTTTACTAT 
GACTACAACA CGGTGCAGAC TGTGGGCATG ACTCTGGCAA CCATCTTGTT CCTGCTGGGT 
ATCCTCATCG TCATCAGCAA GAAGGTGAAG TGCAGGAAGG CGGACTCCAG GTCTGAGAGC 
CCAACCTGCA AATCCTGTAA GTCTGAGCTT CCCTCTTCAG CCCCTGGTGG CGGCGGCGTG 
TAA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_071289.1
CDS	85..327
Translation	MATPTQTPTKAPEEPDPFYYDYNTVQTVGMTLATILFLLGILIVISKKVKCRKADSRSESPTCKSCKSELPSSAPGGGGV

Target ORF information:

RefSeq Version	NM_022006.1
Organism	Homo sapiens(human)
Definition	Homo sapiens FXYD domain containing ion transport regulator 7 (FXYD7), mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_022006.1

ORF Insert Sequence:

ATGGCGACCC CGACCCAGAC CCCCACAAAG GCTCCTGAGG AACCTGACCC ATTTTACTAT 
GACTACAACA CGGTGCAGAC TGTGGGCATG ACTCTGGCAA CCATCTTGTT CCTGCTGGGT 
ATCCTCATCG TCATCAGCAA GAAGGTGAAG TGCAGGAAGG CGGACTCCAG GTCTGAGAGC 
CCAACCTGCA AATCCTGTAA GTCTGAGCTT CCCTCTTCAG CCCCTGGTGG CGGCGGCGTG 
TAA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

PubMed

Intracellular trafficking of FXYD1 (phospholemman) and FXYD7 proteins in Xenopus oocytes and mammalian cells.
The Journal of biological chemistry287(25)21130-41(2012 Jun)
Moshitzky S,Asher C,Garty H

Variation at the NFATC2 locus increases the risk of thiazolidinedione-induced edema in the Diabetes REduction Assessment with ramipril and rosiglitazone Medication (DREAM) study.
Diabetes care33(10)2250-3(2010 Oct)
Bailey SD,Xie C,Do R,Montpetit A,Diaz R,Mohan V,Keavney B,Yusuf S,Gerstein HC,Engert JC,Anand S,

Gene-centric association signals for lipids and apolipoproteins identified via the HumanCVD BeadChip.
American journal of human genetics85(5)628-42(2009 Nov)
Talmud PJ,Drenos F,Shah S,Shah T,Palmen J,Verzilli C,Gaunt TR,Pallas J,Lovering R,Li K,Casas JP,Sofat R,Kumari M,Rodriguez S,Johnson T,Newhouse SJ,Dominiczak A,Samani NJ,Caulfield M,Sever P,Stanton A,Shields DC,Padmanabhan S,Melander O,Hastie C,Delles C,Ebrahim S,Marmot MG,Smith GD,Lawlor DA,Munroe PB,Day IN,Kivimaki M,Whittaker J,Humphries SE,Hingorani AD,,,

FXYD7 is a brain-specific regulator of Na,K-ATPase alpha 1-beta isozymes.
The EMBO journal21(13)3264-73(2002 Jul)
B?guin P,Crambert G,Monnet-Tschudi F,Uldry M,Horisberger JD,Garty H,Geering K

The FXYD gene family of small ion transport regulators or channels: cDNA sequence, protein signature sequence, and expression.
Genomics68(1)41-56(2000 Aug)
Sweadner KJ,Rael E

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FXYD7 cDNA ORF clone, Homo sapiens(human)

Gene

Clones

gRNAs

Related articles in PubMed

Target ORF information:

Target ORF information:

ORF Insert Sequence:

Target ORF information:

Target ORF information:

ORF Insert Sequence:

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