PLCG2 cDNA ORF clone, Homo sapiens(human)

Gene
Clones
gRNAs

Summary

Gene Symbol	PLCG2
Entrez Gene ID	5336
Full Name	phospholipase C gamma 2
Synonyms	APLAID,FCAS3,PLC-IV,PLC-gamma-2
General protein information	Preferred Names phospholipase C gamma 2 Names 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-2 phosphoinositide phospholipase C-gamma-2 phospholipase C, gamma 2 (phosphatidylinositol-specific) phospholipase C-IV
Gene Type	protein-coding
Organism	Homo sapiens(human)
Genome	Chromosome: 16 Map Location: 16q23.3
Summary	The protein encoded by this gene is a transmembrane signaling enzyme that catalyzes the conversion of 1-phosphatidyl-1D-myo-inositol 4,5-bisphosphate to 1D-myo-inositol 1,4,5-trisphosphate (IP3) and diacylglycerol (DAG) using calcium as a cofactor. IP3 and DAG are second messenger molecules important for transmitting signals from growth factor receptors and immune system receptors across the cell membrane. Mutations in this gene have been found in autoinflammation, antibody deficiency, and immune dysregulation syndrome and familial cold autoinflammatory syndrome 3. [provided by RefSeq, Mar 2014].
Disorder MIM:	600220
Disorder Html:	Familial cold autoinflammatory syndrome 3, 614468 (3); Autoinflammation, antibody deficiency, and immune dysregulation syndrome, 614878 (3)

mRNA and Protein(s)

mRNA	Protein	Name
NM_002661.4	NP_002652.2	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-2
NM_002661.5	NP_002652.2	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-2

Pathways from BioSystems

Homologies

Gallus gallus (chicken)	PLCG2	XP_004944314.1
Homo sapiens (human)	PLCG2	NP_002652.2
Pan troglodytes (chimpanzee)	PLCG2	XP_001148089.1
	PLCG2	XP_001111717.1
Mus musculus (house mouse)	Plcg2	NP_758489.1
Arabidopsis thaliana (thale cress)	PLC5	NP_200677.2
Xenopus tropicalis (tropical clawed frog)	plcg2	XP_002934994.2
Bos taurus (cattle)	PLCG2	XP_003587251.2
Danio rerio (zebrafish)	plcg2	NP_001038433.1
Canis lupus familiaris (dog)	PLCG2	XP_005620713.1
Rattus norvegicus (Norway rat)	Plcg2	NP_058864.1

Gene Ontology
Bibliography

Related articles in PubMed

Spleen tyrosine kinase influences the early stages of multilineage differentiation of bone marrow stromal cell lines by regulating phospholipase C gamma activities.
Kusuyama J, Kamisono A, ChangHwan S, Amir MS, Bandow K, Eiraku N, Ohnishi T, Matsuguchi T
Journal of cellular physiology233(3)2549-2559(2018 Mar)

Rare coding variants in PLCG2, ABI3, and TREM2 implicate microglial-mediated innate immunity in Alzheimer's disease.
Sims R, van der Lee SJ, Naj AC, Bellenguez C, Badarinarayan N, Jakobsdottir J, Kunkle BW, Boland A, Raybould R, Bis JC, Martin ER, Grenier-Boley B, Heilmann-Heimbach S, Chouraki V, Kuzma AB, Sleegers K, Vronskaya M, Ruiz A, Graham RR, Olaso R, Hoffmann P, Grove ML, Vardarajan BN, Hiltunen M, N?then MM, White CC, Hamilton-Nelson KL, Epelbaum J, Maier W, Choi SH, Beecham GW, Dulary C, Herms S, Smith AV, Funk CC, Derbois C, Forstner AJ, Ahmad S, Li H, Bacq D, Harold D, Satizabal CL, Valladares O, Squassina A, Thomas R, Brody JA, Qu L, S?nchez-Juan P, Morgan T, Wolters FJ, Zhao Y, Garcia FS, Denning N, Fornage M, Malamon J, Naranjo MCD, Majounie E, Mosley TH, Dombroski B, Wallon D, Lupton MK, Dupuis J, Whitehead P, Fratiglioni L, Medway C, Jian X, Mukherjee S, Keller L, Brown K, Lin H, Cantwell LB, Panza F, McGuinness B, Moreno-Grau S, Burgess JD, Solfrizzi V, Proitsi P, Adams HH, Allen M, Seripa D, Pastor P, Cupples LA, Price ND, Hannequin D, Frank-Garc?a A, Levy D, Chakrabarty P, Caffarra P, Giegling I, Beiser AS, Giedraitis V, Hampel H, Garcia ME, Wang X, Lannfelt L, Mecocci P, Eiriksdottir G, Crane PK, Pasquier F, Boccardi V, Hen?ndez I, Barber RC, Scherer M, Tarraga L, Adams PM, Leber M, Chen Y, Albert MS, Riedel-Heller S, Emilsson V, Beekly D, Braae A, Schmidt R, Blacker D, Masullo C, Schmidt H, Doody RS, Spalletta G, Longstreth WT Jr, Fairchild TJ, Boss? P, Lopez OL, Frosch MP, Sacchinelli E, Ghetti B, Yang Q, Huebinger RM, Jessen F, Li S, Kamboh MI, Morris J, Sotolongo-Grau O, Katz MJ, Corcoran C, Dunstan M, Braddel A, Thomas C, Meggy A, Marshall R, Gerrish A, Chapman J, Aguilar M, Taylor S, Hill M, Fair?n MD, Hodges A, Vellas B, Soininen H, Kloszewska I, Daniilidou M, Uphill J, Patel Y, Hughes JT, Lord J, Turton J, Hartmann AM, Cecchetti R, Fenoglio C, Serpente M, Arcaro M, Caltagirone C, Orfei MD, Ciaramella A, Pichler S, Mayhaus M, Gu W, Lle? A, Fortea J, Blesa R, Barber IS, Brookes K, Cupidi C, Maletta RG, Carrell D, Sorbi S, Moebus S, Urbano M, Pilotto A, Kornhuber J, Bosco P, Todd S, Craig D, Johnston J, Gill M, Lawlor B, Lynch A, Fox NC, Hardy J, , Albin RL, Apostolova LG, Arnold SE, Asthana S, Atwood CS, Baldwin CT, Barnes LL, Barral S, Beach TG, Becker JT, Bigio EH, Bird TD, Boeve BF, Bowen JD, Boxer A, Burke JR, Burns JM, Buxbaum JD, Cairns NJ, Cao C, Carlson CS, Carlsson CM, Carney RM, Carrasquillo MM, Carroll SL, Diaz CC, Chui HC, Clark DG, Cribbs DH, Crocco EA, DeCarli C, Dick M, Duara R, Evans DA, Faber KM, Fallon KB, Fardo DW, Farlow MR, Ferris S, Foroud TM, Galasko DR, Gearing M, Geschwind DH, Gilbert JR, Graff-Radford NR, Green RC, Growdon JH, Hamilton RL, Harrell LE, Honig LS, Huentelman MJ, Hulette CM, Hyman BT, Jarvik GP, Abner E, Jin LW, Jun G, Karydas A, Kaye JA, Kim R, Kowall NW, Kramer JH, LaFerla FM, Lah JJ, Leverenz JB, Levey AI, Li G, Lieberman AP, Lunetta KL, Lyketsos CG, Marson DC, Martiniuk F, Mash DC, Masliah E, McCormick WC, McCurry SM, McDavid AN, McKee AC, Mesulam M, Miller BL, Miller CA, Miller JW, Morris JC, Murrell JR, Myers AJ, O'Bryant S, Olichney JM, Pankratz VS, Parisi JE, Paulson HL, Perry W, Peskind E, Pierce A, Poon WW, Potter H, Quinn JF, Raj A, Raskind M, Reisberg B, Reitz C, Ringman JM, Roberson ED, Rogaeva E, Rosen HJ, Rosenberg RN, Sager MA, Saykin AJ, Schneider JA, Schneider LS, Seeley WW, Smith AG, Sonnen JA, Spina S, Stern RA, Swerdlow RH, Tanzi RE, Thornton-Wells TA, Trojanowski JQ, Troncoso JC, Van Deerlin VM, Van Eldik LJ, Vinters HV, Vonsattel JP, Weintraub S, Welsh-Bohmer KA, Wilhelmsen KC, Williamson J, Wingo TS, Woltjer RL, Wright CB, Yu CE, Yu L, Garzia F, Golamaully F, Septier G, Engelborghs S, Vandenberghe R, De Deyn PP, Fernadez CM, Benito YA, Thonberg H, Forsell C, Lilius L, Kinhult-St?hlbom A, Kilander L, Brundin R, Concari L, Helisalmi S, Koivisto AM, Haapasalo A, Dermecourt V, Fievet N, Hanon O, Dufouil C, Brice A, Ritchie K, Dubois B, Himali JJ, Keene CD, Tschanz J, Fitzpatrick AL, Kukull WA, Norton M, Aspelund T, Larson EB, Munger R, Rotter JI, Lipton RB, Bullido MJ, Hofman A, Montine TJ, Coto E, Boerwinkle E, Petersen RC, Alvarez V, Rivadeneira F, Reiman EM, Gallo M, O'Donnell CJ, Reisch JS, Bruni AC, Royall DR, Dichgans M, Sano M, Galimberti D, St George-Hyslop P, Scarpini E, Tsuang DW, Mancuso M, Bonuccelli U, Winslow AR, Daniele A, Wu CK, , Peters O, Nacmias B, Riemenschneider M, Heun R, Brayne C, Rubinsztein DC, Bras J, Guerreiro R, Al-Chalabi A, Shaw CE, Collinge J, Mann D, Tsolaki M, Clarim?n J, Sussams R, Lovestone S, O'Donovan MC, Owen MJ, Behrens TW, Mead S, Goate AM, Uitterlinden AG, Holmes C, Cruchaga C, Ingelsson M, Bennett DA, Powell J, Golde TE, Graff C, De Jager PL, Morgan K, Ertekin-Taner N, Combarros O, Psaty BM, Passmore P, Younkin SG, Berr C, Gudnason V, Rujescu D, Dickson DW, Dartigues JF, DeStefano AL, Ortega-Cubero S, Hakonarson H, Campion D, Boada M, Kauwe JK, Farrer LA, Van Broeckhoven C, Ikram MA, Jones L, Haines JL, Tzourio C, Launer LJ, Escott-Price V, Mayeux R, Deleuze JF, Amin N, Holmans PA, Pericak-Vance MA, Amouyel P, van Duijn CM, Ramirez A, Wang LS, Lambert JC, Seshadri S, Williams J, Schellenberg GD
Nature genetics49(9)1373-1384(2017 09)

GeneRIFs: Gene References Into Functions What's a GeneRIF?

Syk-induced signals in bone marrow stromal cell lines are mediated by phospholipase C gamma1 (PLCgamma1) in osteogenesis and PLCgamma2 in adipogenesis.
Title: Spleen tyrosine kinase influences the early stages of multilineage differentiation of bone marrow stromal cell lines by regulating phospholipase C gamma activities.

Data show that protein-altering changes are in PLCG2, ABI3, and TREM2 genes highly expressed in microglia and highlight an immune-related protein-protein interaction network in Alzheimer's disease.
Title: Rare coding variants in PLCG2, ABI3, and TREM2 implicate microglial-mediated innate immunity in Alzheimer's disease.

Ocular manifestations of phospholipase-Cgamma2-associated antibody deficiency and immune dysregulation show mutations in the PLC[gamma]2 gene leading to aberrant function of immune cells and overproduction of interleukin-1 [beta] (IL-1[beta]).
Title: Ocular Manifestations of Inherited Phospholipase-C?2-Associated Antibody Deficiency and Immune Dysregulation.

R665W and L845F be referred to as allomorphic rather than hypermorphic mutations of PLCG2 Rerouting of the transmembrane signals emanating from BCR and converging on PLCgamma2 through Rac in ibrutinib-resistant CLL cells may provide novel drug treatment strategies to overcome ibrutinib resistance mediated by PLCG2 mutations or to prevent its development in ibrutinib-treated CLL patients.
Title: The Phospholipase C?2 Mutants R665W and L845F Identified in Ibrutinib-resistant Chronic Lymphocytic Leukemia Patients Are Hypersensitive to the Rho GTPase Rac2 Protein.

The results suggest a new mechanism of PLCgamma activation with unique thermodynamic features and assign a novel regulatory role to its spPH domain.
Title: Cool-temperature-mediated activation of phospholipase C-?2 in the human hereditary disease PLAID.

The following PLCG2 gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the PLCG2 cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1⁺/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.

***CloneID	Accession No.	Definition	**Vector	*Turnaround time	Price (USD)
OHu24072	NM_002661.5 Latest version!	Homo sapiens phospholipase C gamma 2 (PLCG2), mRNA.	pcDNA3.1-C-(k)DYK or customized vector	in pcDNA3.1-C-(k)DYK	$49.50-$69.30 $99.00
View Old Accession Versions >>
OHu24072	NM_002661.4	Homo sapiens phospholipase C gamma 2 (PLCG2), mRNA.	pcDNA3.1-C-(k)DYK or customized vector	in pcDNA3.1-C-(k)DYK	$49.50-$69.30 $99.00
Hide Old Accession Versions >>

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***One clone ID might be correlated to multiple accession numbers, which share the same CDS sequence.

Reference Sequences (Refseq)

PLCG2 ( NM_002661.4 ) cDNA ORF clone, Homo sapiens(human) -> NP_002652.2 Homo sapiens phospholipase C gamma 2 (PLCG2), mRNA.

Price & Availability↑

CloneID	OHu24072
Clone ID Related Accession (Same CDS sequence)	NM_002661.4 , NM_002661.5
Accession Version	NM_002661.4	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 3798bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2017-12-17
Organism	Homo sapiens(human)
Product	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-2
Comment	Comment: REVIEWED REFSEQ: This record has been curated by NCBI staff. The reference sequence was derived from DB456860.1, BP351485.1, BX504887.1, AB208914.1, BC007565.1 and AC092142.5. On Mar 12, 2014 this sequence version replaced NM_002661.3. Sequence Note: This RefSeq record was created from transcript and genomic sequence data to make the sequence consistent with the reference genome assembly. The genomic coordinates used for the transcript record were based on transcript alignments. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## RNAseq introns :: single sample supports all introns SAMEA1965299, SAMEA1966682 [ECO:0000348] ##Evidence-Data-END## COMPLETENESS: full length.

ATGTCCACCA CGGTCAATGT AGATTCCCTT GCGGAATATG AGAAGAGCCA GATCAAGAGA 
GCCCTGGAGC TGGGGACGGT GATGACTGTG TTCAGCTTCC GCAAGTCCAC CCCCGAGCGG 
AGAACCGTCC AGGTGATCAT GGAGACGCGG CAGGTGGCCT GGAGCAAGAC CGCTGACAAG 
ATCGAGGGCT TCTTGGATAT CATGGAAATA AAAGAAATCC GCCCAGGGAA GAACTCCAAA 
GATTTCGAGC GAGCAAAAGC AGTTCGCCAG AAAGAAGACT GCTGCTTCAC CATCCTATAT 
GGCACTCAGT TCGTCCTCAG CACGCTCAGC TTGGCAGCTG ACTCTAAAGA GGATGCAGTT 
AACTGGCTCT CTGGCTTGAA AATCTTACAC CAGGAAGCGA TGAATGCGTC CACGCCCACC 
ATTATCGAGA GTTGGCTGAG AAAGCAGATA TATTCTGTGG ATCAAACCAG AAGAAACAGC 
ATCAGTCTCC GAGAGTTGAA GACCATCTTG CCCCTGATCA ACTTTAAAGT GAGCAGTGCC 
AAGTTCCTTA AAGATAAGTT TGTGGAAATA GGAGCACACA AAGATGAGCT CAGCTTTGAA 
CAGTTCCATC TCTTCTATAA AAAACTTATG TTTGAACAGC AAAAATCGAT TCTCGATGAA 
TTCAAAAAGG ATTCGTCCGT GTTCATCCTG GGGAACACTG ACAGGCCGGA TGCCTCTGCT 
GTTTACCTGC ATGACTTCCA GAGGTTTCTC ATACATGAAC AGCAGGAGCA TTGGGCTCAG 
GATCTGAACA AAGTCCGTGA GCGGATGACA AAGTTCATTG ATGACACCAT GCGTGAAACT 
GCTGAGCCTT TCTTGTTTGT GGATGAGTTC CTCACGTACC TGTTTTCACG AGAAAACAGC 
ATCTGGGATG AGAAGTATGA CGCGGTGGAC ATGCAGGACA TGAACAACCC CCTGTCTCAT 
TACTGGATCT CCTCGTCACA TAACACGTAC CTTACAGGTG ACCAGCTGCG GAGCGAGTCG 
TCCCCAGAAG CTTACATCCG CTGCCTGCGC ATGGGCTGTC GCTGCATTGA ACTGGACTGC 
TGGGACGGGC CCGATGGGAA GCCGGTCATC TACCATGGCT GGACGCGGAC TACCAAGATC 
AAGTTTGACG ACGTCGTGCA GGCCATCAAA GACCACGCCT TTGTTACCTC GAGCTTCCCA 
GTGATCCTGT CCATCGAGGA GCACTGCAGC GTGGAGCAAC AGCGTCACAT GGCCAAGGCC 
TTCAAGGAAG TATTTGGCGA CCTGCTGTTG ACGAAGCCCA CGGAGGCCAG TGCTGACCAG 
CTGCCCTCGC CCAGCCAGCT GCGGGAGAAG ATCATCATCA AGCATAAGAA GCTGGGCCCC 
CGAGGCGATG TGGATGTCAA CATGGAGGAC AAGAAGGACG AACACAAGCA ACAGGGGGAG 
CTGTACATGT GGGATTCCAT TGACCAGAAA TGGACTCGGC ACTACTGCGC CATTGCCGAT 
GCCAAGCTGT CCTTCAGTGA TGACATTGAA CAGACTATGG AGGAGGAAGT GCCCCAGGAT 
ATACCCCCTA CAGAACTACA TTTTGGGGAG AAATGGTTCC ACAAGAAGGT GGAGAAGAGG 
ACGAGTGCCG AGAAGTTGCT GCAGGAATAC TGCATGGAGA CGGGGGGCAA GGATGGCACC 
TTCCTGGTTC GGGAGAGCGA GACCTTCCCC AATGACTACA CCCTGTCCTT CTGGCGGTCA 
GGCCGGGTCC AGCACTGCCG GATCCGCTCC ACCATGGAGG GCGGGACCCT GAAATACTAC 
TTGACTGACA ACCTCACCTT CAGCAGCATC TATGCCCTCA TCCAGCACTA CCGCGAGACG 
CACCTGCGCT GCGCCGAGTT CGAGCTGCGG CTCACGGACC CTGTGCCCAA CCCCAACCCC 
CACGAGTCCA AGCCGTGGTA CTATGACAGC CTGAGCCGCG GAGAGGCAGA GGACATGCTG 
ATGAGGATTC CCCGGGACGG GGCCTTCCTG ATCCGGAAGC GAGAGGGGAG CGACTCCTAT 
GCCATCACCT TCAGGGCTAG GGGCAAGGTA AAGCATTGTC GCATCAACCG GGACGGCCGG 
CACTTTGTGC TGGGGACCTC CGCCTATTTT GAGAGTCTGG TGGAGCTCGT CAGTTACTAC 
GAGAAGCATT CACTCTACCG AAAGATGAGA CTGCGCTACC CCGTGACCCC CGAGCTCCTG 
GAGCGCTACA ATATGGAAAG AGATATAAAC TCCCTCTACG ACGTCAGCAG AATGTATGTG 
GATCCCAGTG AAATCAATCC GTCCATGCCT CAGAGAACCG TGAAAGCTCT GTATGACTAC 
AAAGCCAAGC GAAGCGATGA GCTGAGCTTC TGCCGTGGTG CCCTCATCCA CAATGTCTCC 
AAGGAGCCCG GGGGCTGGTG GAAAGGAGAC TATGGAACCA GGATCCAGCA GTACTTCCCA 
TCCAACTACG TCGAGGACAT CTCAACTGCA GACTTCGAGG AGCTAGAAAA GCAGATTATT 
GAAGACAATC CCTTAGGGTC TCTTTGCAGA GGAATATTGG ACCTCAATAC CTATAACGTC 
GTGAAAGCCC CTCAGGGAAA AAACCAGAAG TCCTTTGTCT TCATCCTGGA GCCCAAGCAG 
CAGGGCGATC CTCCGGTGGA GTTTGCCACA GACAGGGTGG AGGAGCTCTT TGAGTGGTTT 
CAGAGCATCC GAGAGATCAC CTGGAAGATT GACACCAAGG AGAACAACAT GAAGTACTGG 
GAGAAGAACC AGTCCATCGC CATCGAGCTC TCTGACCTGG TTGTCTACTG CAAACCAACC 
AGCAAAACCA AGGACAACTT AGAAAATCCT GACTTCCGAG AAATCCGCTC CTTTGTGGAG 
ACGAAGGCTG ACAGCATCAT CAGACAGAAG CCCGTCGACC TCCTGAAGTA CAATCAAAAG 
GGCCTGACCC GCGTCTACCC AAAGGGACAA AGAGTTGACT CTTCAAACTA CGACCCCTTC 
CGCCTCTGGC TGTGCGGTTC TCAGATGGTG GCACTCAATT TCCAGACGGC AGATAAGTAC 
ATGCAGATGA ATCACGCATT GTTTTCTCTC AATGGGCGCA CGGGCTACGT TCTGCAGCCT 
GAGAGCATGA GGACAGAGAA ATATGACCCG ATGCCACCCG AGTCCCAGAG GAAGATCCTG 
ATGACGCTGA CAGTCAAGGT TCTCGGTGCT CGCCATCTCC CCAAACTTGG ACGAAGTATT 
GCCTGTCCCT TTGTAGAAGT GGAGATCTGT GGAGCCGAGT ATGACAACAA CAAGTTCAAG 
ACGACGGTTG TGAATGATAA TGGCCTCAGC CCTATCTGGG CTCCAACACA GGAGAAGGTG 
ACATTTGAAA TTTATGACCC AAACCTGGCA TTTCTGCGCT TTGTGGTTTA TGAAGAAGAT 
ATGTTCAGCG ATCCCAACTT TCTTGCTCAT GCCACTTACC CCATTAAAGC AGTCAAATCA 
GGATTCAGGT CCGTTCCTCT GAAGAATGGG TACAGCGAGG ACATAGAGCT GGCTTCCCTC 
CTGGTTTTCT GTGAGATGCG GCCAGTCCTG GAGAGCGAAG AGGAACTTTA CTCCTCCTGT 
CGCCAGCTGA GGAGGCGGCA AGAAGAACTG AACAACCAGC TCTTTCTGTA TGACACACAC 
CAGAACTTGC GCAATGCCAA CCGGGATGCC CTGGTTAAAG AGTTCAGTGT TAATGAGAAC 
CAGCTCCAGC TGTACCAGGA GAAATGCAAC AAGAGGTTAA GAGAGAAGAG AGTCAGCAAC 
AGCAAGTTTT ACTCATAG

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_002652.2
CDS	215..4012
Translation	MSTTVNVDSLAEYEKSQIKRALELGTVMTVFSFRKSTPERRTVQVIMETRQVAWSKTADKIEGFLDIMEIKEIRPGKNSKDFERAKAVRQKEDCCFTILYGTQFVLSTLSLAADSKEDAVNWLSGLKILHQEAMNASTPTIIESWLRKQIYSVDQTRRNSISLRELKTILPLINFKVSSAKFLKDKFVEIGAHKDELSFEQFHLFYKKLMFEQQKSILDEFKKDSSVFILGNTDRPDASAVYLHDFQRFLIHEQQEHWAQDLNKVRERMTKFIDDTMRETAEPFLFVDEFLTYLFSRENSIWDEKYDAVDMQDMNNPLSHYWISSSHNTYLTGDQLRSESSPEAYIRCLRMGCRCIELDCWDGPDGKPVIYHGWTRTTKIKFDDVVQAIKDHAFVTSSFPVILSIEEHCSVEQQRHMAKAFKEVFGDLLLTKPTEASADQLPSPSQLREKIIIKHKKLGPRGDVDVNMEDKKDEHKQQGELYMWDSIDQKWTRHYCAIADAKLSFSDDIEQTMEEEVPQDIPPTELHFGEKWFHKKVEKRTSAEKLLQEYCMETGGKDGTFLVRESETFPNDYTLSFWRSGRVQHCRIRSTMEGGTLKYYLTDNLTFSSIYALIQHYRETHLRCAEFELRLTDPVPNPNPHESKPWYYDSLSRGEAEDMLMRIPRDGAFLIRKREGSDSYAITFRARGKVKHCRINRDGRHFVLGTSAYFESLVELVSYYEKHSLYRKMRLRYPVTPELLERYNMERDINSLYDVSRMYVDPSEINPSMPQRTVKALYDYKAKRSDELSFCRGALIHNVSKEPGGWWKGDYGTRIQQYFPSNYVEDISTADFEELEKQIIEDNPLGSLCRGILDLNTYNVVKAPQGKNQKSFVFILEPKQQGDPPVEFATDRVEELFEWFQSIREITWKIDTKENNMKYWEKNQSIAIELSDLVVYCKPTSKTKDNLENPDFREIRSFVETKADSIIRQKPVDLLKYNQKGLTRVYPKGQRVDSSNYDPFRLWLCGSQMVALNFQTADKYMQMNHALFSLNGRTGYVLQPESMRTEKYDPMPPESQRKILMTLTVKVLGARHLPKLGRSIACPFVEVEICGAEYDNNKFKTTVVNDNGLSPIWAPTQEKVTFEIYDPNLAFLRFVVYEEDMFSDPNFLAHATYPIKAVKSGFRSVPLKNGYSEDIELASLLVFCEMRPVLESEEELYSSCRQLRRRQEELNNQLFLYDTHQNLRNANRDALVKEFSVNENQLQLYQEKCNKRLREKRVSNSKFYS

Target ORF information:

RefSeq Version	NM_002661.4
Organism	Homo sapiens(human)
Definition	Homo sapiens phospholipase C gamma 2 (PLCG2), mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_002661.4

ORF Insert Sequence:

ATGTCCACCA CGGTCAATGT AGATTCCCTT GCGGAATATG AGAAGAGCCA GATCAAGAGA 
GCCCTGGAGC TGGGGACGGT GATGACTGTG TTCAGCTTCC GCAAGTCCAC CCCCGAGCGG 
AGAACCGTCC AGGTGATCAT GGAGACGCGG CAGGTGGCCT GGAGCAAGAC CGCTGACAAG 
ATCGAGGGCT TCTTGGATAT CATGGAAATA AAAGAAATCC GCCCAGGGAA GAACTCCAAA 
GATTTCGAGC GAGCAAAAGC AGTTCGCCAG AAAGAAGACT GCTGCTTCAC CATCCTATAT 
GGCACTCAGT TCGTCCTCAG CACGCTCAGC TTGGCAGCTG ACTCTAAAGA GGATGCAGTT 
AACTGGCTCT CTGGCTTGAA AATCTTACAC CAGGAAGCGA TGAATGCGTC CACGCCCACC 
ATTATCGAGA GTTGGCTGAG AAAGCAGATA TATTCTGTGG ATCAAACCAG AAGAAACAGC 
ATCAGTCTCC GAGAGTTGAA GACCATCTTG CCCCTGATCA ACTTTAAAGT GAGCAGTGCC 
AAGTTCCTTA AAGATAAGTT TGTGGAAATA GGAGCACACA AAGATGAGCT CAGCTTTGAA 
CAGTTCCATC TCTTCTATAA AAAACTTATG TTTGAACAGC AAAAATCGAT TCTCGATGAA 
TTCAAAAAGG ATTCGTCCGT GTTCATCCTG GGGAACACTG ACAGGCCGGA TGCCTCTGCT 
GTTTACCTGC ATGACTTCCA GAGGTTTCTC ATACATGAAC AGCAGGAGCA TTGGGCTCAG 
GATCTGAACA AAGTCCGTGA GCGGATGACA AAGTTCATTG ATGACACCAT GCGTGAAACT 
GCTGAGCCTT TCTTGTTTGT GGATGAGTTC CTCACGTACC TGTTTTCACG AGAAAACAGC 
ATCTGGGATG AGAAGTATGA CGCGGTGGAC ATGCAGGACA TGAACAACCC CCTGTCTCAT 
TACTGGATCT CCTCGTCACA TAACACGTAC CTTACAGGTG ACCAGCTGCG GAGCGAGTCG 
TCCCCAGAAG CTTACATCCG CTGCCTGCGC ATGGGCTGTC GCTGCATTGA ACTGGACTGC 
TGGGACGGGC CCGATGGGAA GCCGGTCATC TACCATGGCT GGACGCGGAC TACCAAGATC 
AAGTTTGACG ACGTCGTGCA GGCCATCAAA GACCACGCCT TTGTTACCTC GAGCTTCCCA 
GTGATCCTGT CCATCGAGGA GCACTGCAGC GTGGAGCAAC AGCGTCACAT GGCCAAGGCC 
TTCAAGGAAG TATTTGGCGA CCTGCTGTTG ACGAAGCCCA CGGAGGCCAG TGCTGACCAG 
CTGCCCTCGC CCAGCCAGCT GCGGGAGAAG ATCATCATCA AGCATAAGAA GCTGGGCCCC 
CGAGGCGATG TGGATGTCAA CATGGAGGAC AAGAAGGACG AACACAAGCA ACAGGGGGAG 
CTGTACATGT GGGATTCCAT TGACCAGAAA TGGACTCGGC ACTACTGCGC CATTGCCGAT 
GCCAAGCTGT CCTTCAGTGA TGACATTGAA CAGACTATGG AGGAGGAAGT GCCCCAGGAT 
ATACCCCCTA CAGAACTACA TTTTGGGGAG AAATGGTTCC ACAAGAAGGT GGAGAAGAGG 
ACGAGTGCCG AGAAGTTGCT GCAGGAATAC TGCATGGAGA CGGGGGGCAA GGATGGCACC 
TTCCTGGTTC GGGAGAGCGA GACCTTCCCC AATGACTACA CCCTGTCCTT CTGGCGGTCA 
GGCCGGGTCC AGCACTGCCG GATCCGCTCC ACCATGGAGG GCGGGACCCT GAAATACTAC 
TTGACTGACA ACCTCACCTT CAGCAGCATC TATGCCCTCA TCCAGCACTA CCGCGAGACG 
CACCTGCGCT GCGCCGAGTT CGAGCTGCGG CTCACGGACC CTGTGCCCAA CCCCAACCCC 
CACGAGTCCA AGCCGTGGTA CTATGACAGC CTGAGCCGCG GAGAGGCAGA GGACATGCTG 
ATGAGGATTC CCCGGGACGG GGCCTTCCTG ATCCGGAAGC GAGAGGGGAG CGACTCCTAT 
GCCATCACCT TCAGGGCTAG GGGCAAGGTA AAGCATTGTC GCATCAACCG GGACGGCCGG 
CACTTTGTGC TGGGGACCTC CGCCTATTTT GAGAGTCTGG TGGAGCTCGT CAGTTACTAC 
GAGAAGCATT CACTCTACCG AAAGATGAGA CTGCGCTACC CCGTGACCCC CGAGCTCCTG 
GAGCGCTACA ATATGGAAAG AGATATAAAC TCCCTCTACG ACGTCAGCAG AATGTATGTG 
GATCCCAGTG AAATCAATCC GTCCATGCCT CAGAGAACCG TGAAAGCTCT GTATGACTAC 
AAAGCCAAGC GAAGCGATGA GCTGAGCTTC TGCCGTGGTG CCCTCATCCA CAATGTCTCC 
AAGGAGCCCG GGGGCTGGTG GAAAGGAGAC TATGGAACCA GGATCCAGCA GTACTTCCCA 
TCCAACTACG TCGAGGACAT CTCAACTGCA GACTTCGAGG AGCTAGAAAA GCAGATTATT 
GAAGACAATC CCTTAGGGTC TCTTTGCAGA GGAATATTGG ACCTCAATAC CTATAACGTC 
GTGAAAGCCC CTCAGGGAAA AAACCAGAAG TCCTTTGTCT TCATCCTGGA GCCCAAGCAG 
CAGGGCGATC CTCCGGTGGA GTTTGCCACA GACAGGGTGG AGGAGCTCTT TGAGTGGTTT 
CAGAGCATCC GAGAGATCAC CTGGAAGATT GACACCAAGG AGAACAACAT GAAGTACTGG 
GAGAAGAACC AGTCCATCGC CATCGAGCTC TCTGACCTGG TTGTCTACTG CAAACCAACC 
AGCAAAACCA AGGACAACTT AGAAAATCCT GACTTCCGAG AAATCCGCTC CTTTGTGGAG 
ACGAAGGCTG ACAGCATCAT CAGACAGAAG CCCGTCGACC TCCTGAAGTA CAATCAAAAG 
GGCCTGACCC GCGTCTACCC AAAGGGACAA AGAGTTGACT CTTCAAACTA CGACCCCTTC 
CGCCTCTGGC TGTGCGGTTC TCAGATGGTG GCACTCAATT TCCAGACGGC AGATAAGTAC 
ATGCAGATGA ATCACGCATT GTTTTCTCTC AATGGGCGCA CGGGCTACGT TCTGCAGCCT 
GAGAGCATGA GGACAGAGAA ATATGACCCG ATGCCACCCG AGTCCCAGAG GAAGATCCTG 
ATGACGCTGA CAGTCAAGGT TCTCGGTGCT CGCCATCTCC CCAAACTTGG ACGAAGTATT 
GCCTGTCCCT TTGTAGAAGT GGAGATCTGT GGAGCCGAGT ATGACAACAA CAAGTTCAAG 
ACGACGGTTG TGAATGATAA TGGCCTCAGC CCTATCTGGG CTCCAACACA GGAGAAGGTG 
ACATTTGAAA TTTATGACCC AAACCTGGCA TTTCTGCGCT TTGTGGTTTA TGAAGAAGAT 
ATGTTCAGCG ATCCCAACTT TCTTGCTCAT GCCACTTACC CCATTAAAGC AGTCAAATCA 
GGATTCAGGT CCGTTCCTCT GAAGAATGGG TACAGCGAGG ACATAGAGCT GGCTTCCCTC 
CTGGTTTTCT GTGAGATGCG GCCAGTCCTG GAGAGCGAAG AGGAACTTTA CTCCTCCTGT 
CGCCAGCTGA GGAGGCGGCA AGAAGAACTG AACAACCAGC TCTTTCTGTA TGACACACAC 
CAGAACTTGC GCAATGCCAA CCGGGATGCC CTGGTTAAAG AGTTCAGTGT TAATGAGAAC 
CAGCTCCAGC TGTACCAGGA GAAATGCAAC AAGAGGTTAA GAGAGAAGAG AGTCAGCAAC 
AGCAAGTTTT ACTCATAG

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

PLCG2 ( NM_002661.5 ) cDNA ORF clone, Homo sapiens(human) -> NP_002652.2 Homo sapiens phospholipase C gamma 2 (PLCG2), mRNA.

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CloneID	OHu24072
Clone ID Related Accession (Same CDS sequence)	NM_002661.4 , NM_002661.5
Accession Version	NM_002661.5 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 3798bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-09-25
Organism	Homo sapiens(human)
Product	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-2
Comment	Comment: REVIEWED REFSEQ: This record has been curated by NCBI staff. The reference sequence was derived from DB456860.1, BP351485.1, BX504887.1, AB208914.1, BC007565.1 and AC092142.5. On Nov 22, 2018 this sequence version replaced NM_002661.4. Sequence Note: This RefSeq record was created from transcript and genomic sequence data to make the sequence consistent with the reference genome assembly. The genomic coordinates used for the transcript record were based on transcript alignments. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: AB208914.1, SRR1803616.11578.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA1965299, SAMEA1966682 [ECO:0000348] ##Evidence-Data-END## ##RefSeq-Attributes-START## MANE Ensembl match :: ENST00000564138.6/ ENSP00000482457.1 RefSeq Select criteria :: based on single protein-coding transcript ##RefSeq-Attributes-END## COMPLETENESS: full length.

ATGTCCACCA CGGTCAATGT AGATTCCCTT GCGGAATATG AGAAGAGCCA GATCAAGAGA 
GCCCTGGAGC TGGGGACGGT GATGACTGTG TTCAGCTTCC GCAAGTCCAC CCCCGAGCGG 
AGAACCGTCC AGGTGATCAT GGAGACGCGG CAGGTGGCCT GGAGCAAGAC CGCTGACAAG 
ATCGAGGGCT TCTTGGATAT CATGGAAATA AAAGAAATCC GCCCAGGGAA GAACTCCAAA 
GATTTCGAGC GAGCAAAAGC AGTTCGCCAG AAAGAAGACT GCTGCTTCAC CATCCTATAT 
GGCACTCAGT TCGTCCTCAG CACGCTCAGC TTGGCAGCTG ACTCTAAAGA GGATGCAGTT 
AACTGGCTCT CTGGCTTGAA AATCTTACAC CAGGAAGCGA TGAATGCGTC CACGCCCACC 
ATTATCGAGA GTTGGCTGAG AAAGCAGATA TATTCTGTGG ATCAAACCAG AAGAAACAGC 
ATCAGTCTCC GAGAGTTGAA GACCATCTTG CCCCTGATCA ACTTTAAAGT GAGCAGTGCC 
AAGTTCCTTA AAGATAAGTT TGTGGAAATA GGAGCACACA AAGATGAGCT CAGCTTTGAA 
CAGTTCCATC TCTTCTATAA AAAACTTATG TTTGAACAGC AAAAATCGAT TCTCGATGAA 
TTCAAAAAGG ATTCGTCCGT GTTCATCCTG GGGAACACTG ACAGGCCGGA TGCCTCTGCT 
GTTTACCTGC ATGACTTCCA GAGGTTTCTC ATACATGAAC AGCAGGAGCA TTGGGCTCAG 
GATCTGAACA AAGTCCGTGA GCGGATGACA AAGTTCATTG ATGACACCAT GCGTGAAACT 
GCTGAGCCTT TCTTGTTTGT GGATGAGTTC CTCACGTACC TGTTTTCACG AGAAAACAGC 
ATCTGGGATG AGAAGTATGA CGCGGTGGAC ATGCAGGACA TGAACAACCC CCTGTCTCAT 
TACTGGATCT CCTCGTCACA TAACACGTAC CTTACAGGTG ACCAGCTGCG GAGCGAGTCG 
TCCCCAGAAG CTTACATCCG CTGCCTGCGC ATGGGCTGTC GCTGCATTGA ACTGGACTGC 
TGGGACGGGC CCGATGGGAA GCCGGTCATC TACCATGGCT GGACGCGGAC TACCAAGATC 
AAGTTTGACG ACGTCGTGCA GGCCATCAAA GACCACGCCT TTGTTACCTC GAGCTTCCCA 
GTGATCCTGT CCATCGAGGA GCACTGCAGC GTGGAGCAAC AGCGTCACAT GGCCAAGGCC 
TTCAAGGAAG TATTTGGCGA CCTGCTGTTG ACGAAGCCCA CGGAGGCCAG TGCTGACCAG 
CTGCCCTCGC CCAGCCAGCT GCGGGAGAAG ATCATCATCA AGCATAAGAA GCTGGGCCCC 
CGAGGCGATG TGGATGTCAA CATGGAGGAC AAGAAGGACG AACACAAGCA ACAGGGGGAG 
CTGTACATGT GGGATTCCAT TGACCAGAAA TGGACTCGGC ACTACTGCGC CATTGCCGAT 
GCCAAGCTGT CCTTCAGTGA TGACATTGAA CAGACTATGG AGGAGGAAGT GCCCCAGGAT 
ATACCCCCTA CAGAACTACA TTTTGGGGAG AAATGGTTCC ACAAGAAGGT GGAGAAGAGG 
ACGAGTGCCG AGAAGTTGCT GCAGGAATAC TGCATGGAGA CGGGGGGCAA GGATGGCACC 
TTCCTGGTTC GGGAGAGCGA GACCTTCCCC AATGACTACA CCCTGTCCTT CTGGCGGTCA 
GGCCGGGTCC AGCACTGCCG GATCCGCTCC ACCATGGAGG GCGGGACCCT GAAATACTAC 
TTGACTGACA ACCTCACCTT CAGCAGCATC TATGCCCTCA TCCAGCACTA CCGCGAGACG 
CACCTGCGCT GCGCCGAGTT CGAGCTGCGG CTCACGGACC CTGTGCCCAA CCCCAACCCC 
CACGAGTCCA AGCCGTGGTA CTATGACAGC CTGAGCCGCG GAGAGGCAGA GGACATGCTG 
ATGAGGATTC CCCGGGACGG GGCCTTCCTG ATCCGGAAGC GAGAGGGGAG CGACTCCTAT 
GCCATCACCT TCAGGGCTAG GGGCAAGGTA AAGCATTGTC GCATCAACCG GGACGGCCGG 
CACTTTGTGC TGGGGACCTC CGCCTATTTT GAGAGTCTGG TGGAGCTCGT CAGTTACTAC 
GAGAAGCATT CACTCTACCG AAAGATGAGA CTGCGCTACC CCGTGACCCC CGAGCTCCTG 
GAGCGCTACA ATATGGAAAG AGATATAAAC TCCCTCTACG ACGTCAGCAG AATGTATGTG 
GATCCCAGTG AAATCAATCC GTCCATGCCT CAGAGAACCG TGAAAGCTCT GTATGACTAC 
AAAGCCAAGC GAAGCGATGA GCTGAGCTTC TGCCGTGGTG CCCTCATCCA CAATGTCTCC 
AAGGAGCCCG GGGGCTGGTG GAAAGGAGAC TATGGAACCA GGATCCAGCA GTACTTCCCA 
TCCAACTACG TCGAGGACAT CTCAACTGCA GACTTCGAGG AGCTAGAAAA GCAGATTATT 
GAAGACAATC CCTTAGGGTC TCTTTGCAGA GGAATATTGG ACCTCAATAC CTATAACGTC 
GTGAAAGCCC CTCAGGGAAA AAACCAGAAG TCCTTTGTCT TCATCCTGGA GCCCAAGCAG 
CAGGGCGATC CTCCGGTGGA GTTTGCCACA GACAGGGTGG AGGAGCTCTT TGAGTGGTTT 
CAGAGCATCC GAGAGATCAC CTGGAAGATT GACACCAAGG AGAACAACAT GAAGTACTGG 
GAGAAGAACC AGTCCATCGC CATCGAGCTC TCTGACCTGG TTGTCTACTG CAAACCAACC 
AGCAAAACCA AGGACAACTT AGAAAATCCT GACTTCCGAG AAATCCGCTC CTTTGTGGAG 
ACGAAGGCTG ACAGCATCAT CAGACAGAAG CCCGTCGACC TCCTGAAGTA CAATCAAAAG 
GGCCTGACCC GCGTCTACCC AAAGGGACAA AGAGTTGACT CTTCAAACTA CGACCCCTTC 
CGCCTCTGGC TGTGCGGTTC TCAGATGGTG GCACTCAATT TCCAGACGGC AGATAAGTAC 
ATGCAGATGA ATCACGCATT GTTTTCTCTC AATGGGCGCA CGGGCTACGT TCTGCAGCCT 
GAGAGCATGA GGACAGAGAA ATATGACCCG ATGCCACCCG AGTCCCAGAG GAAGATCCTG 
ATGACGCTGA CAGTCAAGGT TCTCGGTGCT CGCCATCTCC CCAAACTTGG ACGAAGTATT 
GCCTGTCCCT TTGTAGAAGT GGAGATCTGT GGAGCCGAGT ATGACAACAA CAAGTTCAAG 
ACGACGGTTG TGAATGATAA TGGCCTCAGC CCTATCTGGG CTCCAACACA GGAGAAGGTG 
ACATTTGAAA TTTATGACCC AAACCTGGCA TTTCTGCGCT TTGTGGTTTA TGAAGAAGAT 
ATGTTCAGCG ATCCCAACTT TCTTGCTCAT GCCACTTACC CCATTAAAGC AGTCAAATCA 
GGATTCAGGT CCGTTCCTCT GAAGAATGGG TACAGCGAGG ACATAGAGCT GGCTTCCCTC 
CTGGTTTTCT GTGAGATGCG GCCAGTCCTG GAGAGCGAAG AGGAACTTTA CTCCTCCTGT 
CGCCAGCTGA GGAGGCGGCA AGAAGAACTG AACAACCAGC TCTTTCTGTA TGACACACAC 
CAGAACTTGC GCAATGCCAA CCGGGATGCC CTGGTTAAAG AGTTCAGTGT TAATGAGAAC 
CAGCTCCAGC TGTACCAGGA GAAATGCAAC AAGAGGTTAA GAGAGAAGAG AGTCAGCAAC 
AGCAAGTTTT ACTCATAG

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_002652.2
CDS	182..3979
Translation	MSTTVNVDSLAEYEKSQIKRALELGTVMTVFSFRKSTPERRTVQVIMETRQVAWSKTADKIEGFLDIMEIKEIRPGKNSKDFERAKAVRQKEDCCFTILYGTQFVLSTLSLAADSKEDAVNWLSGLKILHQEAMNASTPTIIESWLRKQIYSVDQTRRNSISLRELKTILPLINFKVSSAKFLKDKFVEIGAHKDELSFEQFHLFYKKLMFEQQKSILDEFKKDSSVFILGNTDRPDASAVYLHDFQRFLIHEQQEHWAQDLNKVRERMTKFIDDTMRETAEPFLFVDEFLTYLFSRENSIWDEKYDAVDMQDMNNPLSHYWISSSHNTYLTGDQLRSESSPEAYIRCLRMGCRCIELDCWDGPDGKPVIYHGWTRTTKIKFDDVVQAIKDHAFVTSSFPVILSIEEHCSVEQQRHMAKAFKEVFGDLLLTKPTEASADQLPSPSQLREKIIIKHKKLGPRGDVDVNMEDKKDEHKQQGELYMWDSIDQKWTRHYCAIADAKLSFSDDIEQTMEEEVPQDIPPTELHFGEKWFHKKVEKRTSAEKLLQEYCMETGGKDGTFLVRESETFPNDYTLSFWRSGRVQHCRIRSTMEGGTLKYYLTDNLTFSSIYALIQHYRETHLRCAEFELRLTDPVPNPNPHESKPWYYDSLSRGEAEDMLMRIPRDGAFLIRKREGSDSYAITFRARGKVKHCRINRDGRHFVLGTSAYFESLVELVSYYEKHSLYRKMRLRYPVTPELLERYNMERDINSLYDVSRMYVDPSEINPSMPQRTVKALYDYKAKRSDELSFCRGALIHNVSKEPGGWWKGDYGTRIQQYFPSNYVEDISTADFEELEKQIIEDNPLGSLCRGILDLNTYNVVKAPQGKNQKSFVFILEPKQQGDPPVEFATDRVEELFEWFQSIREITWKIDTKENNMKYWEKNQSIAIELSDLVVYCKPTSKTKDNLENPDFREIRSFVETKADSIIRQKPVDLLKYNQKGLTRVYPKGQRVDSSNYDPFRLWLCGSQMVALNFQTADKYMQMNHALFSLNGRTGYVLQPESMRTEKYDPMPPESQRKILMTLTVKVLGARHLPKLGRSIACPFVEVEICGAEYDNNKFKTTVVNDNGLSPIWAPTQEKVTFEIYDPNLAFLRFVVYEEDMFSDPNFLAHATYPIKAVKSGFRSVPLKNGYSEDIELASLLVFCEMRPVLESEEELYSSCRQLRRRQEELNNQLFLYDTHQNLRNANRDALVKEFSVNENQLQLYQEKCNKRLREKRVSNSKFYS

Target ORF information:

RefSeq Version	NM_002661.5
Organism	Homo sapiens(human)
Definition	Homo sapiens phospholipase C gamma 2 (PLCG2), mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_002661.5

ORF Insert Sequence:

ATGTCCACCA CGGTCAATGT AGATTCCCTT GCGGAATATG AGAAGAGCCA GATCAAGAGA 
GCCCTGGAGC TGGGGACGGT GATGACTGTG TTCAGCTTCC GCAAGTCCAC CCCCGAGCGG 
AGAACCGTCC AGGTGATCAT GGAGACGCGG CAGGTGGCCT GGAGCAAGAC CGCTGACAAG 
ATCGAGGGCT TCTTGGATAT CATGGAAATA AAAGAAATCC GCCCAGGGAA GAACTCCAAA 
GATTTCGAGC GAGCAAAAGC AGTTCGCCAG AAAGAAGACT GCTGCTTCAC CATCCTATAT 
GGCACTCAGT TCGTCCTCAG CACGCTCAGC TTGGCAGCTG ACTCTAAAGA GGATGCAGTT 
AACTGGCTCT CTGGCTTGAA AATCTTACAC CAGGAAGCGA TGAATGCGTC CACGCCCACC 
ATTATCGAGA GTTGGCTGAG AAAGCAGATA TATTCTGTGG ATCAAACCAG AAGAAACAGC 
ATCAGTCTCC GAGAGTTGAA GACCATCTTG CCCCTGATCA ACTTTAAAGT GAGCAGTGCC 
AAGTTCCTTA AAGATAAGTT TGTGGAAATA GGAGCACACA AAGATGAGCT CAGCTTTGAA 
CAGTTCCATC TCTTCTATAA AAAACTTATG TTTGAACAGC AAAAATCGAT TCTCGATGAA 
TTCAAAAAGG ATTCGTCCGT GTTCATCCTG GGGAACACTG ACAGGCCGGA TGCCTCTGCT 
GTTTACCTGC ATGACTTCCA GAGGTTTCTC ATACATGAAC AGCAGGAGCA TTGGGCTCAG 
GATCTGAACA AAGTCCGTGA GCGGATGACA AAGTTCATTG ATGACACCAT GCGTGAAACT 
GCTGAGCCTT TCTTGTTTGT GGATGAGTTC CTCACGTACC TGTTTTCACG AGAAAACAGC 
ATCTGGGATG AGAAGTATGA CGCGGTGGAC ATGCAGGACA TGAACAACCC CCTGTCTCAT 
TACTGGATCT CCTCGTCACA TAACACGTAC CTTACAGGTG ACCAGCTGCG GAGCGAGTCG 
TCCCCAGAAG CTTACATCCG CTGCCTGCGC ATGGGCTGTC GCTGCATTGA ACTGGACTGC 
TGGGACGGGC CCGATGGGAA GCCGGTCATC TACCATGGCT GGACGCGGAC TACCAAGATC 
AAGTTTGACG ACGTCGTGCA GGCCATCAAA GACCACGCCT TTGTTACCTC GAGCTTCCCA 
GTGATCCTGT CCATCGAGGA GCACTGCAGC GTGGAGCAAC AGCGTCACAT GGCCAAGGCC 
TTCAAGGAAG TATTTGGCGA CCTGCTGTTG ACGAAGCCCA CGGAGGCCAG TGCTGACCAG 
CTGCCCTCGC CCAGCCAGCT GCGGGAGAAG ATCATCATCA AGCATAAGAA GCTGGGCCCC 
CGAGGCGATG TGGATGTCAA CATGGAGGAC AAGAAGGACG AACACAAGCA ACAGGGGGAG 
CTGTACATGT GGGATTCCAT TGACCAGAAA TGGACTCGGC ACTACTGCGC CATTGCCGAT 
GCCAAGCTGT CCTTCAGTGA TGACATTGAA CAGACTATGG AGGAGGAAGT GCCCCAGGAT 
ATACCCCCTA CAGAACTACA TTTTGGGGAG AAATGGTTCC ACAAGAAGGT GGAGAAGAGG 
ACGAGTGCCG AGAAGTTGCT GCAGGAATAC TGCATGGAGA CGGGGGGCAA GGATGGCACC 
TTCCTGGTTC GGGAGAGCGA GACCTTCCCC AATGACTACA CCCTGTCCTT CTGGCGGTCA 
GGCCGGGTCC AGCACTGCCG GATCCGCTCC ACCATGGAGG GCGGGACCCT GAAATACTAC 
TTGACTGACA ACCTCACCTT CAGCAGCATC TATGCCCTCA TCCAGCACTA CCGCGAGACG 
CACCTGCGCT GCGCCGAGTT CGAGCTGCGG CTCACGGACC CTGTGCCCAA CCCCAACCCC 
CACGAGTCCA AGCCGTGGTA CTATGACAGC CTGAGCCGCG GAGAGGCAGA GGACATGCTG 
ATGAGGATTC CCCGGGACGG GGCCTTCCTG ATCCGGAAGC GAGAGGGGAG CGACTCCTAT 
GCCATCACCT TCAGGGCTAG GGGCAAGGTA AAGCATTGTC GCATCAACCG GGACGGCCGG 
CACTTTGTGC TGGGGACCTC CGCCTATTTT GAGAGTCTGG TGGAGCTCGT CAGTTACTAC 
GAGAAGCATT CACTCTACCG AAAGATGAGA CTGCGCTACC CCGTGACCCC CGAGCTCCTG 
GAGCGCTACA ATATGGAAAG AGATATAAAC TCCCTCTACG ACGTCAGCAG AATGTATGTG 
GATCCCAGTG AAATCAATCC GTCCATGCCT CAGAGAACCG TGAAAGCTCT GTATGACTAC 
AAAGCCAAGC GAAGCGATGA GCTGAGCTTC TGCCGTGGTG CCCTCATCCA CAATGTCTCC 
AAGGAGCCCG GGGGCTGGTG GAAAGGAGAC TATGGAACCA GGATCCAGCA GTACTTCCCA 
TCCAACTACG TCGAGGACAT CTCAACTGCA GACTTCGAGG AGCTAGAAAA GCAGATTATT 
GAAGACAATC CCTTAGGGTC TCTTTGCAGA GGAATATTGG ACCTCAATAC CTATAACGTC 
GTGAAAGCCC CTCAGGGAAA AAACCAGAAG TCCTTTGTCT TCATCCTGGA GCCCAAGCAG 
CAGGGCGATC CTCCGGTGGA GTTTGCCACA GACAGGGTGG AGGAGCTCTT TGAGTGGTTT 
CAGAGCATCC GAGAGATCAC CTGGAAGATT GACACCAAGG AGAACAACAT GAAGTACTGG 
GAGAAGAACC AGTCCATCGC CATCGAGCTC TCTGACCTGG TTGTCTACTG CAAACCAACC 
AGCAAAACCA AGGACAACTT AGAAAATCCT GACTTCCGAG AAATCCGCTC CTTTGTGGAG 
ACGAAGGCTG ACAGCATCAT CAGACAGAAG CCCGTCGACC TCCTGAAGTA CAATCAAAAG 
GGCCTGACCC GCGTCTACCC AAAGGGACAA AGAGTTGACT CTTCAAACTA CGACCCCTTC 
CGCCTCTGGC TGTGCGGTTC TCAGATGGTG GCACTCAATT TCCAGACGGC AGATAAGTAC 
ATGCAGATGA ATCACGCATT GTTTTCTCTC AATGGGCGCA CGGGCTACGT TCTGCAGCCT 
GAGAGCATGA GGACAGAGAA ATATGACCCG ATGCCACCCG AGTCCCAGAG GAAGATCCTG 
ATGACGCTGA CAGTCAAGGT TCTCGGTGCT CGCCATCTCC CCAAACTTGG ACGAAGTATT 
GCCTGTCCCT TTGTAGAAGT GGAGATCTGT GGAGCCGAGT ATGACAACAA CAAGTTCAAG 
ACGACGGTTG TGAATGATAA TGGCCTCAGC CCTATCTGGG CTCCAACACA GGAGAAGGTG 
ACATTTGAAA TTTATGACCC AAACCTGGCA TTTCTGCGCT TTGTGGTTTA TGAAGAAGAT 
ATGTTCAGCG ATCCCAACTT TCTTGCTCAT GCCACTTACC CCATTAAAGC AGTCAAATCA 
GGATTCAGGT CCGTTCCTCT GAAGAATGGG TACAGCGAGG ACATAGAGCT GGCTTCCCTC 
CTGGTTTTCT GTGAGATGCG GCCAGTCCTG GAGAGCGAAG AGGAACTTTA CTCCTCCTGT 
CGCCAGCTGA GGAGGCGGCA AGAAGAACTG AACAACCAGC TCTTTCTGTA TGACACACAC 
CAGAACTTGC GCAATGCCAA CCGGGATGCC CTGGTTAAAG AGTTCAGTGT TAATGAGAAC 
CAGCTCCAGC TGTACCAGGA GAAATGCAAC AAGAGGTTAA GAGAGAAGAG AGTCAGCAAC 
AGCAAGTTTT ACTCATAG

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

PubMed

Spleen tyrosine kinase influences the early stages of multilineage differentiation of bone marrow stromal cell lines by regulating phospholipase C gamma activities.
Journal of cellular physiology233(3)2549-2559(2018 Mar)
Kusuyama J,Kamisono A,ChangHwan S,Amir MS,Bandow K,Eiraku N,Ohnishi T,Matsuguchi T

Rare coding variants in PLCG2, ABI3, and TREM2 implicate microglial-mediated innate immunity in Alzheimer's disease.
Nature genetics49(9)1373-1384(2017 09)
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PLCG2 cDNA ORF clone, Homo sapiens(human)

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Target ORF information:

Target ORF information:

ORF Insert Sequence:

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ORF Insert Sequence:

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