SPA17 cDNA ORF clone, Homo sapiens(human)

Gene
Clones
gRNAs

Summary

Gene Symbol	SPA17
Entrez Gene ID	53340
Full Name	sperm autoantigenic protein 17
Synonyms	CT22,SP17,SP17-1
General protein information	Preferred Names sperm autoantigenic protein 17 Names sperm surface protein Sp17 cancer/testis antigen 22 sperm protein 17
Gene Type	protein-coding
Organism	Homo sapiens(human)
Genome	Chromosome: 11 Map Location: 11q24.2
Summary	This gene encodes a protein present at the cell surface. The N-terminus has sequence similarity to human cAMP-dependent protein kinase A (PKA) type II alpha regulatory subunit (RIIa) while the C-terminus has an IQ calmodulin-binding motif. The central portion of the protein has carbohydrate binding motifs and likely functions in cell-cell adhesion. The protein was initially characterized by its involvement in the binding of sperm to the zona pellucida of the oocyte. Recent studies indicate that it is also involved in additional cell-cell adhesion functions such as immune cell migration and metastasis. A retrotransposed pseudogene is present on chromosome 10q22.[provided by RefSeq, Jan 2009].
Disorder MIM:	608621

mRNA and Protein(s)

mRNA	Protein	Name
XM_011542870.1	XP_011541172.1	sperm surface protein Sp17 isoform X1
NM_017425.3	NP_059121.1	sperm surface protein Sp17
XM_024448583.1	XP_024304351.1	sperm surface protein Sp17 isoform X1
XM_011542870.2	XP_011541172.1	sperm surface protein Sp17 isoform X1

Pathways from BioSystems

Homologies

Bos taurus (cattle)	SPA17	NP_001069908.1
Rattus norvegicus (Norway rat)	Spa17	NP_445934.1
Pan troglodytes (chimpanzee)	SPA17	XP_003313445.1
Homo sapiens (human)	SPA17	NP_059121.1
	SPA17	NP_001165553.1
Canis lupus familiaris (dog)	SPA17	XP_858799.1
Mus musculus (house mouse)	Spa17	NP_035579.1
Xenopus tropicalis (tropical clawed frog)	spa17	NP_001006758.1

Gene Ontology
Bibliography

Related articles in PubMed

Architecture of the human interactome defines protein communities and disease networks.
Huttlin EL, Bruckner RJ, Paulo JA, Cannon JR, Ting L, Baltier K, Colby G, Gebreab F, Gygi MP, Parzen H, Szpyt J, Tam S, Zarraga G, Pontano-Vaites L, Swarup S, White AE, Schweppe DK, Rad R, Erickson BK, Obar RA, Guruharsha KG, Li K, Artavanis-Tsakonas S, Gygi SP, Harper JW
Nature545(7655)505-509(2017 05)

Umbilical cord blood-derived dendritic cells infected by adenovirus for SP17 expression induce antigen-specific cytotoxic T cells against NSCLC cells.
Liu Y, Tian X, Jiang S, Ren X, Liu F, Yang J, Chen Y, Jiang Y
Cellular immunology298(1-2)18-24(2015 Nov-Dec)

Widespread macromolecular interaction perturbations in human genetic disorders.
Sahni N, Yi S, Taipale M, Fuxman Bass JI, Coulombe-Huntington J, Yang F, Peng J, Weile J, Karras GI, Wang Y, Kov?cs IA, Kamburov A, Krykbaeva I, Lam MH, Tucker G, Khurana V, Sharma A, Liu YY, Yachie N, Zhong Q, Shen Y, Palagi A, San-Miguel A, Fan C, Balcha D, Dricot A, Jordan DM, Walsh JM, Shah AA, Yang X, Stoyanova AK, Leighton A, Calderwood MA, Jacob Y, Cusick ME, Salehi-Ashtiani K, Whitesell LJ, Sunyaev S, Berger B, Barab?si AL, Charloteaux B, Hill DE, Hao T, Roth FP, Xia Y, Walhout AJM, Lindquist S, Vidal M
Cell161(3)647-660(2015 Apr)

Novel antigens in non-small cell lung cancer: SP17, AKAP4, and PTTG1 are potential immunotherapeutic targets.
Mirandola L, Figueroa JA, Phan TT, Grizzi F, Kim M, Rahman RL, Jenkins MR, Cobos E, Jumper C, Alalawi R, Chiriva-Internati M
Oncotarget6(5)2812-26(2015 Feb)

GeneRIFs: Gene References Into Functions What's a GeneRIF?

dendritic cells from human umbilical cord blood modulated for SP17 expression induced antigen-specific anti-tumor immunity against SP17(+) non-small cell lung cancer.
Title: Umbilical cord blood-derived dendritic cells infected by adenovirus for SP17 expression induce antigen-specific cytotoxic T cells against NSCLC cells.

Sp17 and ASP cancer/testis antigens were found in ciliated cells of four ciliated hepatic foregut cysts (CHFCs). Further characterization of Sp17 and ASP in patients with CHFCs may provide significant clues for understanding the molecular mechanisms underlying their predisposition to develop squamous cell carcinomas.
Title: Sperm protein 17 and AKAP-associated sperm protein cancer/testis antigens are expressed in ciliated hepatic foregut cysts.

SP17/AKAP4/PTTG1 are expressed in both human NSCLC cell lines and primary tumors and can elicit an immunogenic response in lung cancer patients.
Title: Novel antigens in non-small cell lung cancer: SP17, AKAP4, and PTTG1 are potential immunotherapeutic targets.

NY-ESO-1 and SP17 was not significantly associated with a specific histotype, but high-level GAGE expression was more frequent in squamous cell carcinoma. GAGE expression was demonstrated to be significantly higher in stage II-IIIa than stage I NSCLC.
Title: Analysis of GAGE, NY-ESO-1 and SP17 cancer/testis antigen expression in early stage non-small cell lung carcinoma.

Sp17 is highly expressed in hepatocellular carcinoma cells
Title: Sperm protein 17, MAGE-C1 and NY-ESO-1 in hepatocellular carcinoma: expression frequency and their correlation with clinical parameters.

The following SPA17 gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the SPA17 cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1⁺/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.

***CloneID	Accession No.	Definition	**Vector	*Turnaround time	Price (USD)
OHu13635	NM_017425.3 Latest version!	Homo sapiens sperm autoantigenic protein 17 (SPA17), mRNA.	pcDNA3.1-C-(k)DYK or customized vector	in pcDNA3.1-C-(k)DYK	$49.50-$69.30 $99.00
OHu13635	XM_024448583.1 Latest version!	Homo sapiens sperm autoantigenic protein 17 (SPA17), transcript variant X2, mRNA.	pcDNA3.1-C-(k)DYK or customized vector	in pcDNA3.1-C-(k)DYK	$49.50-$69.30 $99.00
OHu13635	XM_011542870.2 Latest version!	Homo sapiens sperm autoantigenic protein 17 (SPA17), transcript variant X1, mRNA.	pcDNA3.1-C-(k)DYK or customized vector	in pcDNA3.1-C-(k)DYK	$49.50-$69.30 $99.00
View Old Accession Versions >>
OHu13635	XM_011542870.1	Homo sapiens sperm autoantigenic protein 17 (SPA17), transcript variant X1, mRNA.	pcDNA3.1-C-(k)DYK or customized vector	in pcDNA3.1-C-(k)DYK	$49.50-$69.30 $99.00
Hide Old Accession Versions >>

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***One clone ID might be correlated to multiple accession numbers, which share the same CDS sequence.

Reference Sequences (Refseq)

SPA17 ( NM_017425.3 ) cDNA ORF clone, Homo sapiens(human) -> NP_059121.1 Homo sapiens sperm autoantigenic protein 17 (SPA17), mRNA.

Price & Availability↑

CloneID	OHu13635
Clone ID Related Accession (Same CDS sequence)	XM_011542870.1 , NM_017425.3 , XM_024448583.1 , XM_011542870.2
Accession Version	NM_017425.3 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 456bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-10-09
Organism	Homo sapiens(human)
Product	sperm surface protein Sp17
Comment	Comment: REVIEWED REFSEQ: This record has been curated by NCBI staff. The reference sequence was derived from DA511916.1 and AF334735.1. On Jan 24, 2009 this sequence version replaced NM_017425.2. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: AF334735.1, SRR1163657.221379.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA1965299, SAMEA1966682 [ECO:0000348] ##Evidence-Data-END## ##RefSeq-Attributes-START## RefSeq Select criteria :: based on conservation, expression, longest protein ##RefSeq-Attributes-END## COMPLETENESS: complete on the 3' end.

ATGTCGATTC CATTCTCCAA CACCCACTAC CGAATTCCAC AAGGATTTGG GAATCTTCTT 
GAAGGGCTGA CACGCGAGAT TCTGAGAGAG CAACCGGACA ATATACCAGC TTTTGCAGCA 
GCCTATTTTG AGAGCCTTCT AGAGAAAAGA GAGAAAACCA ACTTTGATCC AGCAGAATGG 
GGGAGTAAGG TAGAAGACCG CTTCTATAAC AATCATGCAT TCGAGGAGCA AGAACCACCT 
GAGAAAAGTG ATCCTAAACA AGAAGAGTCT CAGATATCTG GGAAGGAGGA AGAGACATCA 
GTCACCATCT TAGACTCTTC TGAGGAAGAT AAGGAAAAAG AAGAGGTTGC TGCTGTCAAA 
ATCCAAGCTG CCTTCCGGGG ACACATAGCC AGAGAGGAGG CAAAGAAAAT GAAAACAAAT 
AGTCTTCAAA ATGAGGAAAA AGAGGAAAAC AAGTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_059121.1
CDS	137..592
Translation	MSIPFSNTHYRIPQGFGNLLEGLTREILREQPDNIPAFAAAYFESLLEKREKTNFDPAEWGSKVEDRFYNNHAFEEQEPPEKSDPKQEESQISGKEEETSVTILDSSEEDKEKEEVAAVKIQAAFRGHIAREEAKKMKTNSLQNEEKEENK

Target ORF information:

RefSeq Version	NM_017425.3
Organism	Homo sapiens(human)
Definition	Homo sapiens sperm autoantigenic protein 17 (SPA17), mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_017425.3

ORF Insert Sequence:

ATGTCGATTC CATTCTCCAA CACCCACTAC CGAATTCCAC AAGGATTTGG GAATCTTCTT 
GAAGGGCTGA CACGCGAGAT TCTGAGAGAG CAACCGGACA ATATACCAGC TTTTGCAGCA 
GCCTATTTTG AGAGCCTTCT AGAGAAAAGA GAGAAAACCA ACTTTGATCC AGCAGAATGG 
GGGAGTAAGG TAGAAGACCG CTTCTATAAC AATCATGCAT TCGAGGAGCA AGAACCACCT 
GAGAAAAGTG ATCCTAAACA AGAAGAGTCT CAGATATCTG GGAAGGAGGA AGAGACATCA 
GTCACCATCT TAGACTCTTC TGAGGAAGAT AAGGAAAAAG AAGAGGTTGC TGCTGTCAAA 
ATCCAAGCTG CCTTCCGGGG ACACATAGCC AGAGAGGAGG CAAAGAAAAT GAAAACAAAT 
AGTCTTCAAA ATGAGGAAAA AGAGGAAAAC AAGTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

SPA17 ( XM_011542870.1 ) cDNA ORF clone, Homo sapiens(human) -> XP_011541172.1 Homo sapiens sperm autoantigenic protein 17 (SPA17), transcript variant X1, mRNA.

Price & Availability↑

CloneID	OHu13635
Clone ID Related Accession (Same CDS sequence)	XM_011542870.1 , NM_017425.3 , XM_024448583.1 , XM_011542870.2
Accession Version	XM_011542870.1	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 456bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2015-03-11
Organism	Homo sapiens(Human)
Product	sperm surface protein Sp17 isoform X1
Comment

ATGTCGATTC CATTCTCCAA CACCCACTAC CGAATTCCAC AAGGATTTGG GAATCTTCTT 
GAAGGGCTGA CACGCGAGAT TCTGAGAGAG CAACCGGACA ATATACCAGC TTTTGCAGCA 
GCCTATTTTG AGAGCCTTCT AGAGAAAAGA GAGAAAACCA ACTTTGATCC AGCAGAATGG 
GGGAGTAAGG TAGAAGACCG CTTCTATAAC AATCATGCAT TCGAGGAGCA AGAACCACCT 
GAGAAAAGTG ATCCTAAACA AGAAGAGTCT CAGATATCTG GGAAGGAGGA AGAGACATCA 
GTCACCATCT TAGACTCTTC TGAGGAAGAT AAGGAAAAAG AAGAGGTTGC TGCTGTCAAA 
ATCCAAGCTG CCTTCCGGGG ACACATAGCC AGAGAGGAGG CAAAGAAAAT GAAAACAAAT 
AGTCTTCAAA ATGAGGAAAA AGAGGAAAAC AAGTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	XP_011541172.1
Translation	MSIPFSNTHYRIPQGFGNLLEGLTREILREQPDNIPAFAAAYFESLLEKREKTNFDPAEWGSKVEDRFYNNHAFEEQEPPEKSDPKQEESQISGKEEETSVTILDSSEEDKEKEEVAAVKIQAAFRGHIAREEAKKMKTNSLQNEEKEENK

Target ORF information:

RefSeq Version	XM_011542870.1
Organism	Homo sapiens(Human)
Definition	Homo sapiens sperm autoantigenic protein 17 (SPA17), transcript variant X1, mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

XM_011542870.1

ORF Insert Sequence:

ATGTCGATTC CATTCTCCAA CACCCACTAC CGAATTCCAC AAGGATTTGG GAATCTTCTT 
GAAGGGCTGA CACGCGAGAT TCTGAGAGAG CAACCGGACA ATATACCAGC TTTTGCAGCA 
GCCTATTTTG AGAGCCTTCT AGAGAAAAGA GAGAAAACCA ACTTTGATCC AGCAGAATGG 
GGGAGTAAGG TAGAAGACCG CTTCTATAAC AATCATGCAT TCGAGGAGCA AGAACCACCT 
GAGAAAAGTG ATCCTAAACA AGAAGAGTCT CAGATATCTG GGAAGGAGGA AGAGACATCA 
GTCACCATCT TAGACTCTTC TGAGGAAGAT AAGGAAAAAG AAGAGGTTGC TGCTGTCAAA 
ATCCAAGCTG CCTTCCGGGG ACACATAGCC AGAGAGGAGG CAAAGAAAAT GAAAACAAAT 
AGTCTTCAAA ATGAGGAAAA AGAGGAAAAC AAGTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

SPA17 ( XM_024448583.1 ) cDNA ORF clone, Homo sapiens(human) -> XP_024304351.1 Homo sapiens sperm autoantigenic protein 17 (SPA17), transcript variant X2, mRNA.

Price & Availability↑

CloneID	OHu13635
Clone ID Related Accession (Same CDS sequence)	XM_011542870.1 , NM_017425.3 , XM_024448583.1 , XM_011542870.2
Accession Version	XM_024448583.1 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 456bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-12-05
Organism	Homo sapiens(human)
Product	sperm surface protein Sp17 isoform X1
Comment	Comment: MODEL REFSEQ: This record is predicted by automated computational analysis. This record is derived from a genomic sequence (NC_000011.10) annotated using gene prediction method: Gnomon, supported by mRNA and EST evidence. Also see: Documentation of NCBI's Annotation Process ##Genome-Annotation-Data-START## Annotation Provider :: NCBI Annotation Status :: Updated annotation Annotation Name :: Homo sapiens Updated Annotation Release 109.20191205 Annotation Version :: 109.20191205 Annotation Pipeline :: NCBI eukaryotic genome annotation pipeline Annotation Software Version :: 8.3 Annotation Method :: Best-placed RefSeq; propagated RefSeq model Features Annotated :: Gene; mRNA; CDS; ncRNA ##Genome-Annotation-Data-END##

ATGTCGATTC CATTCTCCAA CACCCACTAC CGAATTCCAC AAGGATTTGG GAATCTTCTT 
GAAGGGCTGA CACGCGAGAT TCTGAGAGAG CAACCGGACA ATATACCAGC TTTTGCAGCA 
GCCTATTTTG AGAGCCTTCT AGAGAAAAGA GAGAAAACCA ACTTTGATCC AGCAGAATGG 
GGGAGTAAGG TAGAAGACCG CTTCTATAAC AATCATGCAT TCGAGGAGCA AGAACCACCT 
GAGAAAAGTG ATCCTAAACA AGAAGAGTCT CAGATATCTG GGAAGGAGGA AGAGACATCA 
GTCACCATCT TAGACTCTTC TGAGGAAGAT AAGGAAAAAG AAGAGGTTGC TGCTGTCAAA 
ATCCAAGCTG CCTTCCGGGG ACACATAGCC AGAGAGGAGG CAAAGAAAAT GAAAACAAAT 
AGTCTTCAAA ATGAGGAAAA AGAGGAAAAC AAGTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	XP_024304351.1
CDS	191..646
Translation	MSIPFSNTHYRIPQGFGNLLEGLTREILREQPDNIPAFAAAYFESLLEKREKTNFDPAEWGSKVEDRFYNNHAFEEQEPPEKSDPKQEESQISGKEEETSVTILDSSEEDKEKEEVAAVKIQAAFRGHIAREEAKKMKTNSLQNEEKEENK

Target ORF information:

RefSeq Version	XM_024448583.1
Organism	Homo sapiens(human)
Definition	Homo sapiens sperm autoantigenic protein 17 (SPA17), transcript variant X2, mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

XM_024448583.1

ORF Insert Sequence:

ATGTCGATTC CATTCTCCAA CACCCACTAC CGAATTCCAC AAGGATTTGG GAATCTTCTT 
GAAGGGCTGA CACGCGAGAT TCTGAGAGAG CAACCGGACA ATATACCAGC TTTTGCAGCA 
GCCTATTTTG AGAGCCTTCT AGAGAAAAGA GAGAAAACCA ACTTTGATCC AGCAGAATGG 
GGGAGTAAGG TAGAAGACCG CTTCTATAAC AATCATGCAT TCGAGGAGCA AGAACCACCT 
GAGAAAAGTG ATCCTAAACA AGAAGAGTCT CAGATATCTG GGAAGGAGGA AGAGACATCA 
GTCACCATCT TAGACTCTTC TGAGGAAGAT AAGGAAAAAG AAGAGGTTGC TGCTGTCAAA 
ATCCAAGCTG CCTTCCGGGG ACACATAGCC AGAGAGGAGG CAAAGAAAAT GAAAACAAAT 
AGTCTTCAAA ATGAGGAAAA AGAGGAAAAC AAGTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

SPA17 ( XM_011542870.2 ) cDNA ORF clone, Homo sapiens(human) -> XP_011541172.1 Homo sapiens sperm autoantigenic protein 17 (SPA17), transcript variant X1, mRNA.

Price & Availability↑

CloneID	OHu13635
Clone ID Related Accession (Same CDS sequence)	XM_011542870.1 , NM_017425.3 , XM_024448583.1 , XM_011542870.2
Accession Version	XM_011542870.2 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 456bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-12-05
Organism	Homo sapiens(human)
Product	sperm surface protein Sp17 isoform X1
Comment	Comment: MODEL REFSEQ: This record is predicted by automated computational analysis. This record is derived from a genomic sequence (NC_000011.10) annotated using gene prediction method: Gnomon, supported by mRNA and EST evidence. Also see: Documentation of NCBI's Annotation Process On Jun 6, 2016 this sequence version replaced XM_011542870.1. ##Genome-Annotation-Data-START## Annotation Provider :: NCBI Annotation Status :: Updated annotation Annotation Name :: Homo sapiens Updated Annotation Release 109.20191205 Annotation Version :: 109.20191205 Annotation Pipeline :: NCBI eukaryotic genome annotation pipeline Annotation Software Version :: 8.3 Annotation Method :: Best-placed RefSeq; propagated RefSeq model Features Annotated :: Gene; mRNA; CDS; ncRNA ##Genome-Annotation-Data-END##

ATGTCGATTC CATTCTCCAA CACCCACTAC CGAATTCCAC AAGGATTTGG GAATCTTCTT 
GAAGGGCTGA CACGCGAGAT TCTGAGAGAG CAACCGGACA ATATACCAGC TTTTGCAGCA 
GCCTATTTTG AGAGCCTTCT AGAGAAAAGA GAGAAAACCA ACTTTGATCC AGCAGAATGG 
GGGAGTAAGG TAGAAGACCG CTTCTATAAC AATCATGCAT TCGAGGAGCA AGAACCACCT 
GAGAAAAGTG ATCCTAAACA AGAAGAGTCT CAGATATCTG GGAAGGAGGA AGAGACATCA 
GTCACCATCT TAGACTCTTC TGAGGAAGAT AAGGAAAAAG AAGAGGTTGC TGCTGTCAAA 
ATCCAAGCTG CCTTCCGGGG ACACATAGCC AGAGAGGAGG CAAAGAAAAT GAAAACAAAT 
AGTCTTCAAA ATGAGGAAAA AGAGGAAAAC AAGTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	XP_011541172.1
CDS	327..782
Translation	MSIPFSNTHYRIPQGFGNLLEGLTREILREQPDNIPAFAAAYFESLLEKREKTNFDPAEWGSKVEDRFYNNHAFEEQEPPEKSDPKQEESQISGKEEETSVTILDSSEEDKEKEEVAAVKIQAAFRGHIAREEAKKMKTNSLQNEEKEENK

Target ORF information:

RefSeq Version	XM_011542870.2
Organism	Homo sapiens(human)
Definition	Homo sapiens sperm autoantigenic protein 17 (SPA17), transcript variant X1, mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

XM_011542870.2

ORF Insert Sequence:

ATGTCGATTC CATTCTCCAA CACCCACTAC CGAATTCCAC AAGGATTTGG GAATCTTCTT 
GAAGGGCTGA CACGCGAGAT TCTGAGAGAG CAACCGGACA ATATACCAGC TTTTGCAGCA 
GCCTATTTTG AGAGCCTTCT AGAGAAAAGA GAGAAAACCA ACTTTGATCC AGCAGAATGG 
GGGAGTAAGG TAGAAGACCG CTTCTATAAC AATCATGCAT TCGAGGAGCA AGAACCACCT 
GAGAAAAGTG ATCCTAAACA AGAAGAGTCT CAGATATCTG GGAAGGAGGA AGAGACATCA 
GTCACCATCT TAGACTCTTC TGAGGAAGAT AAGGAAAAAG AAGAGGTTGC TGCTGTCAAA 
ATCCAAGCTG CCTTCCGGGG ACACATAGCC AGAGAGGAGG CAAAGAAAAT GAAAACAAAT 
AGTCTTCAAA ATGAGGAAAA AGAGGAAAAC AAGTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

PubMed

Architecture of the human interactome defines protein communities and disease networks.
Nature545(7655)505-509(2017 05)
Huttlin EL,Bruckner RJ,Paulo JA,Cannon JR,Ting L,Baltier K,Colby G,Gebreab F,Gygi MP,Parzen H,Szpyt J,Tam S,Zarraga G,Pontano-Vaites L,Swarup S,White AE,Schweppe DK,Rad R,Erickson BK,Obar RA,Guruharsha KG,Li K,Artavanis-Tsakonas S,Gygi SP,Harper JW

Umbilical cord blood-derived dendritic cells infected by adenovirus for SP17 expression induce antigen-specific cytotoxic T cells against NSCLC cells.
Cellular immunology298(1-2)18-24(2015 Nov-Dec)
Liu Y,Tian X,Jiang S,Ren X,Liu F,Yang J,Chen Y,Jiang Y

Widespread macromolecular interaction perturbations in human genetic disorders.
Cell161(3)647-660(2015 Apr)
Sahni N,Yi S,Taipale M,Fuxman Bass JI,Coulombe-Huntington J,Yang F,Peng J,Weile J,Karras GI,Wang Y,Kov?cs IA,Kamburov A,Krykbaeva I,Lam MH,Tucker G,Khurana V,Sharma A,Liu YY,Yachie N,Zhong Q,Shen Y,Palagi A,San-Miguel A,Fan C,Balcha D,Dricot A,Jordan DM,Walsh JM,Shah AA,Yang X,Stoyanova AK,Leighton A,Calderwood MA,Jacob Y,Cusick ME,Salehi-Ashtiani K,Whitesell LJ,Sunyaev S,Berger B,Barab?si AL,Charloteaux B,Hill DE,Hao T,Roth FP,Xia Y,Walhout AJM,Lindquist S,Vidal M

Novel antigens in non-small cell lung cancer: SP17, AKAP4, and PTTG1 are potential immunotherapeutic targets.
Oncotarget6(5)2812-26(2015 Feb)
Mirandola L,Figueroa JA,Phan TT,Grizzi F,Kim M,Rahman RL,Jenkins MR,Cobos E,Jumper C,Alalawi R,Chiriva-Internati M

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SPA17 cDNA ORF clone, Homo sapiens(human)

Gene

Clones

gRNAs

Related articles in PubMed

Target ORF information:

Target ORF information:

ORF Insert Sequence:

Target ORF information:

Target ORF information:

ORF Insert Sequence:

Target ORF information:

Target ORF information:

ORF Insert Sequence:

Target ORF information:

Target ORF information:

ORF Insert Sequence:

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