PKP1 cDNA ORF clone, Homo sapiens(human)

Gene
Clones
gRNAs

Summary

Gene Symbol	PKP1
Entrez Gene ID	5317
Full Name	plakophilin 1
Synonyms	B6P
General protein information	Preferred Names plakophilin 1 Names plakophilin-1 band 6 protein
Gene Type	protein-coding
Organism	Homo sapiens(human)
Genome	Chromosome: 1 Map Location: 1q32.1
Summary	This gene encodes a member of the arm-repeat (armadillo) and plakophilin gene families. Plakophilin proteins contain numerous armadillo repeats, localize to cell desmosomes and nuclei, and participate in linking cadherins to intermediate filaments in the cytoskeleton. This protein may be involved in molecular recruitment and stabilization during desmosome formation. Mutations in this gene have been associated with the ectodermal dysplasia/skin fragility syndrome. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2010].
Disorder MIM:	601975
Disorder Html:	Ectodermal dysplasia/skin fragility syndrome, 604536 (3)

mRNA and Protein(s)

mRNA	Protein	Name
NM_000299.3	NP_000290.2	plakophilin-1 isoform 1b
NM_001005337.2	NP_001005337.1	plakophilin-1 isoform 1a
NM_001005337.3	NP_001005337.1	plakophilin-1 isoform 1a

Pathways from BioSystems

Homologies

Mus musculus (house mouse)	Pkp1	NP_062619.1
Canis lupus familiaris (dog)	PKP1	XP_856621.1
Homo sapiens (human)	PKP1	NP_001005337.1
	PKP1	XP_002802045.1
Canis lupus familiaris (dog)	LOC100855871	XP_003639190.1
Rattus norvegicus (Norway rat)	Pkp1	NP_001100651.1
Gallus gallus (chicken)	PKP1	XP_419240.3
Pan troglodytes (chimpanzee)	PKP1	XP_003308733.1
Bos taurus (cattle)	PKP1	NP_776570.1
Danio rerio (zebrafish)	pkp1b	XP_001338299.2
Xenopus tropicalis (tropical clawed frog)	pkp1	XP_002932184.2

Gene Ontology
Bibliography

Related articles in PubMed

Plakophilin-1, a Novel Wnt Signaling Regulator, Is Critical for Tooth Development and Ameloblast Differentiation.
Miyazaki K, Yoshizaki K, Arai C, Yamada A, Saito K, Ishikawa M, Xue H, Funada K, Haruyama N, Yamada Y, Fukumoto S, Takahashi I
PloS one11(3)e0152206(2016)

Plakophilin 1-deficient cells upregulate SPOCK1: implications for prostate cancer progression.
Yang C, Fischer-Ke?o R, Schlechter T, Str?bel P, Marx A, Hofmann I
Tumour biology : the journal of the International Society for Oncodevelopmental Biology and Medicine36(12)9567-77(2015 Dec)

The nuclear localization pattern and interaction partners of GTF2IRD1 demonstrate a role in chromatin regulation.
Carmona-Mora P, Widagdo J, Tomasetig F, Canales CP, Cha Y, Lee W, Alshawaf A, Dottori M, Whan RM, Hardeman EC, Palmer SJ
Human genetics134(10)1099-115(2015 Oct)

Plakophilins 1 and 3 bind to FXR1 and thereby influence the mRNA stability of desmosomal proteins.
Fischer-Ke?o R, Breuninger S, Hofmann S, Henn M, R?hrig T, Str?bel P, Stoecklin G, Hofmann I
Molecular and cellular biology34(23)4244-56(2014 Dec)

GeneRIFs: Gene References Into Functions What's a GeneRIF?

These results implicate the participation of PKP1 in early tooth morphogenesis as an effector of canonical Wnt signaling that controls ameloblast differentiation via regulation of the cell adhesion complex
Title: Plakophilin-1, a Novel Wnt Signaling Regulator, Is Critical for Tooth Development and Ameloblast Differentiation.

Collectively, altered expression of PKP1 and SPOCK1 appears to be a frequent and critical event in prostate cancer
Title: Plakophilin 1-deficient cells upregulate SPOCK1: implications for prostate cancer progression.

cytoplasmic PKP1/3 are components of mRNA ribonucleoprotein particles and act as posttranscriptional regulators of gene expression.
Title: Plakophilins 1 and 3 bind to FXR1 and thereby influence the mRNA stability of desmosomal proteins.

Plakophilin-1 has a role in protecting keratinocytes from pemphigus vulgaris IgG by forming calcium-independent desmosomes
Title: Plakophilin-1 protects keratinocytes from pemphigus vulgaris IgG by forming calcium-independent desmosomes.

Data indicate that upon activation of growth factor signaling, plakophilin 1 switches from a desmosome-associated growth-inhibiting to a cytoplasmic proliferation-promoting function.
Title: Insulin signaling via Akt2 switches plakophilin 1 function from stabilizing cell adhesion to promoting cell proliferation.

The following PKP1 gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the PKP1 cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1⁺/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.

***CloneID	Accession No.	Definition	**Vector	*Turnaround time	Price (USD)
OHu28330	NM_000299.3 Latest version!	Homo sapiens plakophilin 1 (PKP1), transcript variant 1b, mRNA.	pcDNA3.1-C-(k)DYK or customized vector	in pcDNA3.1-C-(k)DYK	$379.50-$531.30 $759.00
OHu28333	NM_001005337.3 Latest version!	Homo sapiens plakophilin 1 (PKP1), transcript variant 1a, mRNA.	pcDNA3.1-C-(k)DYK or customized vector	12-14	$265.30 $379.00
View Old Accession Versions >>
OHu28333	NM_001005337.2	Homo sapiens plakophilin 1 (PKP1), transcript variant 1a, mRNA.	pcDNA3.1-C-(k)DYK or customized vector	12-14	$265.30 $379.00
Hide Old Accession Versions >>

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** GenScript guarantees 100% sequence accuracy of all synthetic DNA constructs we deliver, but we do not guarantee protein expression in your experimental system. Protein expression is influenced by many factors that may vary between experiments or laboratories. In addition, please pay attention to the signal peptide, propeptide and transit peptide in target ORF, which may affect the choice of vector (N/C terminal tag vector).

***One clone ID might be correlated to multiple accession numbers, which share the same CDS sequence.

Reference Sequences (Refseq)

PKP1 ( NM_000299.3 ) cDNA ORF clone, Homo sapiens(human) -> NP_000290.2 Homo sapiens plakophilin 1 (PKP1), transcript variant 1b, mRNA.

Price & Availability↑

CloneID	OHu28330
Clone ID Related Accession (Same CDS sequence)	NM_000299.3
Accession Version	NM_000299.3 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 2244bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-11-04
Organism	Homo sapiens(human)
Product	plakophilin-1 isoform 1b
Comment	Comment: REVIEWED REFSEQ: This record has been curated by NCBI staff. The reference sequence was derived from Z34974.1 and AC119427.3. This sequence is a reference standard in the RefSeqGene project. On Jul 2, 2010 this sequence version replaced NM_000299.2. Transcript Variant: This variant (1b) represents the longer transcript variant and encodes the longer protein (isoform 1b). Sequence Note: This RefSeq record was created from transcript and genomic sequence data to make the sequence consistent with the reference genome assembly. The genomic coordinates used for the transcript record were based on transcript alignments. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## RNAseq introns :: mixed/partial sample support SAMEA2145893, SAMEA2156670 [ECO:0000350] ##Evidence-Data-END## COMPLETENESS: complete on the 3' end.

ATGAACCACT CGCCGCTCAA GACCGCCTTG GCGTACGAAT GCTTCCAGGA CCAGGACAAC 
TCCACGTTGG CTTTGCCGTC GGACCAAAAG ATGAAAACAG GCACGTCTGG CAGGCAGCGC 
GTGCAGGAGC AGGTGATGAT GACCGTCAAG CGGCAGAAGT CCAAGTCTTC CCAGTCGTCC 
ACCCTGAGCC ACTCCAATCG AGGTTCCATG TATGATGGCT TGGCTGACAA TTACAACTAT 
GGGACCACCA GCAGGAGCAG CTACTACTCC AAGTTCCAGG CAGGGAATGG CTCATGGGGA 
TATCCGATCT ACAATGGAAC CCTCAAGCGG GAGCCTGACA ACAGGCGCTT CAGCTCCTAC 
AGCCAGATGG AGAACTGGAG CCGGCACTAC CCCCGGGGCA GCTGTAACAC CACCGGCGCA 
GGCAGCGACA TCTGCTTCAT GCAGAAAATC AAGGCGAGCC GCAGTGAGCC CGACCTCTAC 
TGTGACCCAC GGGGCACCCT GCGCAAGGGC ACGCTGGGCA GCAAGGGCCA GAAGACCACC 
CAGAACCGCT ACAGCTTTTA CAGCACCTGC AGTGGTCAGA AGGCCATAAA GAAGTGCCCT 
GTGCGCCCGC CCTCTTGTGC CTCCAAGCAG GACCCTGTGT ATATCCCGCC CATCTCCTGC 
AACAAGGACC TGTCCTTTGG CCACTCTAGG GCCAGCTCCA AGATCTGCAG TGAGGACATC 
GAGTGCAGTG GGCTGACCAT CCCCAAGGCT GTGCAGTACC TGAGCTCCCA GGATGAGAAG 
TACCAGGCCA TTGGGGCCTA TTACATCCAG CATACCTGCT TCCAGGATGA ATCTGCCAAG 
CAACAGGTCT ATCAGCTGGG AGGCATCTGC AAGCTGGTGG ACCTCCTCCG CAGCCCCAAC 
CAGAACGTCC AGCAGGCCGC GGCAGGGGCC CTGCGCAACC TGGTGTTCAG GAGCACCACC 
AACAAGCTGG AGACCCGGAG GCAGAATGGG ATCCGCGAGG CAGTCAGCCT CCTGAGGAGA 
ACCGGGAACG CCGAGATCCA GAAGCAGCTG ACTGGGCTGC TCTGGAACCT GTCTTCCACT 
GACGAGCTGA AGGAGGAACT CATTGCCGAC GCCCTGCCTG TTCTGGCCGA CCGCGTCATC 
ATTCCCTTCT CTGGCTGGTG CGATGGCAAT AGCAACATGT CCCGGGAAGT GGTGGACCCT 
GAGGTCTTCT TCAATGCCAC AGGCTGCTTG AGAAAGAGAC TGGGCATGCG GGAGCTTCTG 
GCTCTTGTTC CGCAAAGGGC CACTAGTAGC AGGGTGAACC TGAGCTCGGC CGATGCAGGC 
CGCCAGACCA TGCGTAACTA CTCAGGGCTC ATTGATTCCC TCATGGCCTA TGTCCAGAAC 
TGTGTAGCGG CCAGCCGCTG TGACGACAAG TCTGTGGAAA ACTGCATGTG TGTTCTGCAC 
AACCTCTCCT ACCGCCTGGA CGCCGAGGTG CCCACCCGCT ACCGCCAGCT GGAGTATAAC 
GCCCGCAACG CCTACACCGA GAAGTCCTCC ACTGGCTGCT TCAGCAACAA GAGCGACAAG 
ATGATGAACA ACAACTATGA CTGCCCCCTG CCTGAGGAAG AGACCAACCC CAAGGGCAGC 
GGCTGGTTGT ACCATTCAGA TGCCATCCGC ACCTACCTGA ACCTCATGGG CAAGAGCAAG 
AAAGATGCTA CCCTGGAGGC CTGTGCTGGT GCCCTGCAGA ACCTGACAGC CAGCAAGGGG 
CTGATGTCCA GTGGCATGAG CCAGTTGATT GGGCTGAAGG AAAAGGGCCT GCCACAAATT 
GCCCGCCTCC TGCAATCTGG CAACTCTGAT GTGGTGCGGT CCGGAGCCTC CCTCCTGAGC 
AACATGTCCC GCCACCCTCT GCTGCACAGA GTGATGGGGA ACCAGGTGTT CCCGGAGGTG 
ACCAGGCTCC TCACCAGCCA CACTGGCAAT ACCAGCAACT CCGAAGACAT CTTGTCCTCG 
GCCTGCTACA CTGTGAGGAA CCTGATGGCC TCGCAGCCAC AACTGGCCAA GCAGTACTTC 
TCCAGCAGCA TGCTCAACAA CATCATCAAC CTGTGCCGAA GCAGTGCCTC ACCCAAGGCC 
GCAGAAGCTG CCCGGCTTCT CCTGTCTGAC ATGTGGTCCA GCAAGGAACT GCAGGGTGTC 
CTCAGACAGC AAGGTTTCGA TAGGAACATG CTGGGAACCT TAGCTGGGGC CAACAGCCTC 
AGGAACTTCA CCTCCCGATT CTAA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_000290.2
CDS	252..2495
Translation	MNHSPLKTALAYECFQDQDNSTLALPSDQKMKTGTSGRQRVQEQVMMTVKRQKSKSSQSSTLSHSNRGSMYDGLADNYNYGTTSRSSYYSKFQAGNGSWGYPIYNGTLKREPDNRRFSSYSQMENWSRHYPRGSCNTTGAGSDICFMQKIKASRSEPDLYCDPRGTLRKGTLGSKGQKTTQNRYSFYSTCSGQKAIKKCPVRPPSCASKQDPVYIPPISCNKDLSFGHSRASSKICSEDIECSGLTIPKAVQYLSSQDEKYQAIGAYYIQHTCFQDESAKQQVYQLGGICKLVDLLRSPNQNVQQAAAGALRNLVFRSTTNKLETRRQNGIREAVSLLRRTGNAEIQKQLTGLLWNLSSTDELKEELIADALPVLADRVIIPFSGWCDGNSNMSREVVDPEVFFNATGCLRKRLGMRELLALVPQRATSSRVNLSSADAGRQTMRNYSGLIDSLMAYVQNCVAASRCDDKSVENCMCVLHNLSYRLDAEVPTRYRQLEYNARNAYTEKSSTGCFSNKSDKMMNNNYDCPLPEEETNPKGSGWLYHSDAIRTYLNLMGKSKKDATLEACAGALQNLTASKGLMSSGMSQLIGLKEKGLPQIARLLQSGNSDVVRSGASLLSNMSRHPLLHRVMGNQVFPEVTRLLTSHTGNTSNSEDILSSACYTVRNLMASQPQLAKQYFSSSMLNNIINLCRSSASPKAAEAARLLLSDMWSSKELQGVLRQQGFDRNMLGTLAGANSLRNFTSRF

Target ORF information:

RefSeq Version	NM_000299.3
Organism	Homo sapiens(human)
Definition	Homo sapiens plakophilin 1 (PKP1), transcript variant 1b, mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_000299.3

ORF Insert Sequence:

ATGAACCACT CGCCGCTCAA GACCGCCTTG GCGTACGAAT GCTTCCAGGA CCAGGACAAC 
TCCACGTTGG CTTTGCCGTC GGACCAAAAG ATGAAAACAG GCACGTCTGG CAGGCAGCGC 
GTGCAGGAGC AGGTGATGAT GACCGTCAAG CGGCAGAAGT CCAAGTCTTC CCAGTCGTCC 
ACCCTGAGCC ACTCCAATCG AGGTTCCATG TATGATGGCT TGGCTGACAA TTACAACTAT 
GGGACCACCA GCAGGAGCAG CTACTACTCC AAGTTCCAGG CAGGGAATGG CTCATGGGGA 
TATCCGATCT ACAATGGAAC CCTCAAGCGG GAGCCTGACA ACAGGCGCTT CAGCTCCTAC 
AGCCAGATGG AGAACTGGAG CCGGCACTAC CCCCGGGGCA GCTGTAACAC CACCGGCGCA 
GGCAGCGACA TCTGCTTCAT GCAGAAAATC AAGGCGAGCC GCAGTGAGCC CGACCTCTAC 
TGTGACCCAC GGGGCACCCT GCGCAAGGGC ACGCTGGGCA GCAAGGGCCA GAAGACCACC 
CAGAACCGCT ACAGCTTTTA CAGCACCTGC AGTGGTCAGA AGGCCATAAA GAAGTGCCCT 
GTGCGCCCGC CCTCTTGTGC CTCCAAGCAG GACCCTGTGT ATATCCCGCC CATCTCCTGC 
AACAAGGACC TGTCCTTTGG CCACTCTAGG GCCAGCTCCA AGATCTGCAG TGAGGACATC 
GAGTGCAGTG GGCTGACCAT CCCCAAGGCT GTGCAGTACC TGAGCTCCCA GGATGAGAAG 
TACCAGGCCA TTGGGGCCTA TTACATCCAG CATACCTGCT TCCAGGATGA ATCTGCCAAG 
CAACAGGTCT ATCAGCTGGG AGGCATCTGC AAGCTGGTGG ACCTCCTCCG CAGCCCCAAC 
CAGAACGTCC AGCAGGCCGC GGCAGGGGCC CTGCGCAACC TGGTGTTCAG GAGCACCACC 
AACAAGCTGG AGACCCGGAG GCAGAATGGG ATCCGCGAGG CAGTCAGCCT CCTGAGGAGA 
ACCGGGAACG CCGAGATCCA GAAGCAGCTG ACTGGGCTGC TCTGGAACCT GTCTTCCACT 
GACGAGCTGA AGGAGGAACT CATTGCCGAC GCCCTGCCTG TTCTGGCCGA CCGCGTCATC 
ATTCCCTTCT CTGGCTGGTG CGATGGCAAT AGCAACATGT CCCGGGAAGT GGTGGACCCT 
GAGGTCTTCT TCAATGCCAC AGGCTGCTTG AGAAAGAGAC TGGGCATGCG GGAGCTTCTG 
GCTCTTGTTC CGCAAAGGGC CACTAGTAGC AGGGTGAACC TGAGCTCGGC CGATGCAGGC 
CGCCAGACCA TGCGTAACTA CTCAGGGCTC ATTGATTCCC TCATGGCCTA TGTCCAGAAC 
TGTGTAGCGG CCAGCCGCTG TGACGACAAG TCTGTGGAAA ACTGCATGTG TGTTCTGCAC 
AACCTCTCCT ACCGCCTGGA CGCCGAGGTG CCCACCCGCT ACCGCCAGCT GGAGTATAAC 
GCCCGCAACG CCTACACCGA GAAGTCCTCC ACTGGCTGCT TCAGCAACAA GAGCGACAAG 
ATGATGAACA ACAACTATGA CTGCCCCCTG CCTGAGGAAG AGACCAACCC CAAGGGCAGC 
GGCTGGTTGT ACCATTCAGA TGCCATCCGC ACCTACCTGA ACCTCATGGG CAAGAGCAAG 
AAAGATGCTA CCCTGGAGGC CTGTGCTGGT GCCCTGCAGA ACCTGACAGC CAGCAAGGGG 
CTGATGTCCA GTGGCATGAG CCAGTTGATT GGGCTGAAGG AAAAGGGCCT GCCACAAATT 
GCCCGCCTCC TGCAATCTGG CAACTCTGAT GTGGTGCGGT CCGGAGCCTC CCTCCTGAGC 
AACATGTCCC GCCACCCTCT GCTGCACAGA GTGATGGGGA ACCAGGTGTT CCCGGAGGTG 
ACCAGGCTCC TCACCAGCCA CACTGGCAAT ACCAGCAACT CCGAAGACAT CTTGTCCTCG 
GCCTGCTACA CTGTGAGGAA CCTGATGGCC TCGCAGCCAC AACTGGCCAA GCAGTACTTC 
TCCAGCAGCA TGCTCAACAA CATCATCAAC CTGTGCCGAA GCAGTGCCTC ACCCAAGGCC 
GCAGAAGCTG CCCGGCTTCT CCTGTCTGAC ATGTGGTCCA GCAAGGAACT GCAGGGTGTC 
CTCAGACAGC AAGGTTTCGA TAGGAACATG CTGGGAACCT TAGCTGGGGC CAACAGCCTC 
AGGAACTTCA CCTCCCGATT CTAA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

PKP1 ( NM_001005337.2 ) cDNA ORF clone, Homo sapiens(human) -> NP_001005337.1 Homo sapiens plakophilin 1 (PKP1), transcript variant 1a, mRNA.

Price & Availability↑

CloneID	OHu28333
Clone ID Related Accession (Same CDS sequence)	NM_001005337.2 , NM_001005337.3
Accession Version	NM_001005337.2	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 2181bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-02-22
Organism	Homo sapiens(human)
Product	plakophilin-1 isoform 1a
Comment	Comment: REVIEWED REFSEQ: This record has been curated by NCBI staff. The reference sequence was derived from Z34974.1 and AC119427.3. On Jul 2, 2010 this sequence version replaced NM_001005337.1. Transcript Variant: This variant (1a) represents the shorter transcript variant as compared to variant 1b. It encodes the shorter protein (isoform 1a), compared to isoform 1b. Sequence Note: This RefSeq record was created from transcript and genomic sequence data to make the sequence consistent with the reference genome assembly. The genomic coordinates used for the transcript record were based on transcript alignments. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: BC114571.1, Z34974.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA1968832, SAMEA2142680 [ECO:0000348] ##Evidence-Data-END## COMPLETENESS: complete on the 3' end.

ATGAACCACT CGCCGCTCAA GACCGCCTTG GCGTACGAAT GCTTCCAGGA CCAGGACAAC 
TCCACGTTGG CTTTGCCGTC GGACCAAAAG ATGAAAACAG GCACGTCTGG CAGGCAGCGC 
GTGCAGGAGC AGGTGATGAT GACCGTCAAG CGGCAGAAGT CCAAGTCTTC CCAGTCGTCC 
ACCCTGAGCC ACTCCAATCG AGGTTCCATG TATGATGGCT TGGCTGACAA TTACAACTAT 
GGGACCACCA GCAGGAGCAG CTACTACTCC AAGTTCCAGG CAGGGAATGG CTCATGGGGA 
TATCCGATCT ACAATGGAAC CCTCAAGCGG GAGCCTGACA ACAGGCGCTT CAGCTCCTAC 
AGCCAGATGG AGAACTGGAG CCGGCACTAC CCCCGGGGCA GCTGTAACAC CACCGGCGCA 
GGCAGCGACA TCTGCTTCAT GCAGAAAATC AAGGCGAGCC GCAGTGAGCC CGACCTCTAC 
TGTGACCCAC GGGGCACCCT GCGCAAGGGC ACGCTGGGCA GCAAGGGCCA GAAGACCACC 
CAGAACCGCT ACAGCTTTTA CAGCACCTGC AGTGGTCAGA AGGCCATAAA GAAGTGCCCT 
GTGCGCCCGC CCTCTTGTGC CTCCAAGCAG GACCCTGTGT ATATCCCGCC CATCTCCTGC 
AACAAGGACC TGTCCTTTGG CCACTCTAGG GCCAGCTCCA AGATCTGCAG TGAGGACATC 
GAGTGCAGTG GGCTGACCAT CCCCAAGGCT GTGCAGTACC TGAGCTCCCA GGATGAGAAG 
TACCAGGCCA TTGGGGCCTA TTACATCCAG CATACCTGCT TCCAGGATGA ATCTGCCAAG 
CAACAGGTCT ATCAGCTGGG AGGCATCTGC AAGCTGGTGG ACCTCCTCCG CAGCCCCAAC 
CAGAACGTCC AGCAGGCCGC GGCAGGGGCC CTGCGCAACC TGGTGTTCAG GAGCACCACC 
AACAAGCTGG AGACCCGGAG GCAGAATGGG ATCCGCGAGG CAGTCAGCCT CCTGAGGAGA 
ACCGGGAACG CCGAGATCCA GAAGCAGCTG ACTGGGCTGC TCTGGAACCT GTCTTCCACT 
GACGAGCTGA AGGAGGAACT CATTGCCGAC GCCCTGCCTG TTCTGGCCGA CCGCGTCATC 
ATTCCCTTCT CTGGCTGGTG CGATGGCAAT AGCAACATGT CCCGGGAAGT GGTGGACCCT 
GAGGTCTTCT TCAATGCCAC AGGCTGCTTG AGGAACCTGA GCTCGGCCGA TGCAGGCCGC 
CAGACCATGC GTAACTACTC AGGGCTCATT GATTCCCTCA TGGCCTATGT CCAGAACTGT 
GTAGCGGCCA GCCGCTGTGA CGACAAGTCT GTGGAAAACT GCATGTGTGT TCTGCACAAC 
CTCTCCTACC GCCTGGACGC CGAGGTGCCC ACCCGCTACC GCCAGCTGGA GTATAACGCC 
CGCAACGCCT ACACCGAGAA GTCCTCCACT GGCTGCTTCA GCAACAAGAG CGACAAGATG 
ATGAACAACA ACTATGACTG CCCCCTGCCT GAGGAAGAGA CCAACCCCAA GGGCAGCGGC 
TGGTTGTACC ATTCAGATGC CATCCGCACC TACCTGAACC TCATGGGCAA GAGCAAGAAA 
GATGCTACCC TGGAGGCCTG TGCTGGTGCC CTGCAGAACC TGACAGCCAG CAAGGGGCTG 
ATGTCCAGTG GCATGAGCCA GTTGATTGGG CTGAAGGAAA AGGGCCTGCC ACAAATTGCC 
CGCCTCCTGC AATCTGGCAA CTCTGATGTG GTGCGGTCCG GAGCCTCCCT CCTGAGCAAC 
ATGTCCCGCC ACCCTCTGCT GCACAGAGTG ATGGGGAACC AGGTGTTCCC GGAGGTGACC 
AGGCTCCTCA CCAGCCACAC TGGCAATACC AGCAACTCCG AAGACATCTT GTCCTCGGCC 
TGCTACACTG TGAGGAACCT GATGGCCTCG CAGCCACAAC TGGCCAAGCA GTACTTCTCC 
AGCAGCATGC TCAACAACAT CATCAACCTG TGCCGAAGCA GTGCCTCACC CAAGGCCGCA 
GAAGCTGCCC GGCTTCTCCT GTCTGACATG TGGTCCAGCA AGGAACTGCA GGGTGTCCTC 
AGACAGCAAG GTTTCGATAG GAACATGCTG GGAACCTTAG CTGGGGCCAA CAGCCTCAGG 
AACTTCACCT CCCGATTCTA A

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_001005337.1
CDS	252..2432
Translation	MNHSPLKTALAYECFQDQDNSTLALPSDQKMKTGTSGRQRVQEQVMMTVKRQKSKSSQSSTLSHSNRGSMYDGLADNYNYGTTSRSSYYSKFQAGNGSWGYPIYNGTLKREPDNRRFSSYSQMENWSRHYPRGSCNTTGAGSDICFMQKIKASRSEPDLYCDPRGTLRKGTLGSKGQKTTQNRYSFYSTCSGQKAIKKCPVRPPSCASKQDPVYIPPISCNKDLSFGHSRASSKICSEDIECSGLTIPKAVQYLSSQDEKYQAIGAYYIQHTCFQDESAKQQVYQLGGICKLVDLLRSPNQNVQQAAAGALRNLVFRSTTNKLETRRQNGIREAVSLLRRTGNAEIQKQLTGLLWNLSSTDELKEELIADALPVLADRVIIPFSGWCDGNSNMSREVVDPEVFFNATGCLRNLSSADAGRQTMRNYSGLIDSLMAYVQNCVAASRCDDKSVENCMCVLHNLSYRLDAEVPTRYRQLEYNARNAYTEKSSTGCFSNKSDKMMNNNYDCPLPEEETNPKGSGWLYHSDAIRTYLNLMGKSKKDATLEACAGALQNLTASKGLMSSGMSQLIGLKEKGLPQIARLLQSGNSDVVRSGASLLSNMSRHPLLHRVMGNQVFPEVTRLLTSHTGNTSNSEDILSSACYTVRNLMASQPQLAKQYFSSSMLNNIINLCRSSASPKAAEAARLLLSDMWSSKELQGVLRQQGFDRNMLGTLAGANSLRNFTSRF

Target ORF information:

RefSeq Version	NM_001005337.2
Organism	Homo sapiens(human)
Definition	Homo sapiens plakophilin 1 (PKP1), transcript variant 1a, mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_001005337.2

ORF Insert Sequence:

ATGAACCACT CGCCGCTCAA GACCGCCTTG GCGTACGAAT GCTTCCAGGA CCAGGACAAC 
TCCACGTTGG CTTTGCCGTC GGACCAAAAG ATGAAAACAG GCACGTCTGG CAGGCAGCGC 
GTGCAGGAGC AGGTGATGAT GACCGTCAAG CGGCAGAAGT CCAAGTCTTC CCAGTCGTCC 
ACCCTGAGCC ACTCCAATCG AGGTTCCATG TATGATGGCT TGGCTGACAA TTACAACTAT 
GGGACCACCA GCAGGAGCAG CTACTACTCC AAGTTCCAGG CAGGGAATGG CTCATGGGGA 
TATCCGATCT ACAATGGAAC CCTCAAGCGG GAGCCTGACA ACAGGCGCTT CAGCTCCTAC 
AGCCAGATGG AGAACTGGAG CCGGCACTAC CCCCGGGGCA GCTGTAACAC CACCGGCGCA 
GGCAGCGACA TCTGCTTCAT GCAGAAAATC AAGGCGAGCC GCAGTGAGCC CGACCTCTAC 
TGTGACCCAC GGGGCACCCT GCGCAAGGGC ACGCTGGGCA GCAAGGGCCA GAAGACCACC 
CAGAACCGCT ACAGCTTTTA CAGCACCTGC AGTGGTCAGA AGGCCATAAA GAAGTGCCCT 
GTGCGCCCGC CCTCTTGTGC CTCCAAGCAG GACCCTGTGT ATATCCCGCC CATCTCCTGC 
AACAAGGACC TGTCCTTTGG CCACTCTAGG GCCAGCTCCA AGATCTGCAG TGAGGACATC 
GAGTGCAGTG GGCTGACCAT CCCCAAGGCT GTGCAGTACC TGAGCTCCCA GGATGAGAAG 
TACCAGGCCA TTGGGGCCTA TTACATCCAG CATACCTGCT TCCAGGATGA ATCTGCCAAG 
CAACAGGTCT ATCAGCTGGG AGGCATCTGC AAGCTGGTGG ACCTCCTCCG CAGCCCCAAC 
CAGAACGTCC AGCAGGCCGC GGCAGGGGCC CTGCGCAACC TGGTGTTCAG GAGCACCACC 
AACAAGCTGG AGACCCGGAG GCAGAATGGG ATCCGCGAGG CAGTCAGCCT CCTGAGGAGA 
ACCGGGAACG CCGAGATCCA GAAGCAGCTG ACTGGGCTGC TCTGGAACCT GTCTTCCACT 
GACGAGCTGA AGGAGGAACT CATTGCCGAC GCCCTGCCTG TTCTGGCCGA CCGCGTCATC 
ATTCCCTTCT CTGGCTGGTG CGATGGCAAT AGCAACATGT CCCGGGAAGT GGTGGACCCT 
GAGGTCTTCT TCAATGCCAC AGGCTGCTTG AGGAACCTGA GCTCGGCCGA TGCAGGCCGC 
CAGACCATGC GTAACTACTC AGGGCTCATT GATTCCCTCA TGGCCTATGT CCAGAACTGT 
GTAGCGGCCA GCCGCTGTGA CGACAAGTCT GTGGAAAACT GCATGTGTGT TCTGCACAAC 
CTCTCCTACC GCCTGGACGC CGAGGTGCCC ACCCGCTACC GCCAGCTGGA GTATAACGCC 
CGCAACGCCT ACACCGAGAA GTCCTCCACT GGCTGCTTCA GCAACAAGAG CGACAAGATG 
ATGAACAACA ACTATGACTG CCCCCTGCCT GAGGAAGAGA CCAACCCCAA GGGCAGCGGC 
TGGTTGTACC ATTCAGATGC CATCCGCACC TACCTGAACC TCATGGGCAA GAGCAAGAAA 
GATGCTACCC TGGAGGCCTG TGCTGGTGCC CTGCAGAACC TGACAGCCAG CAAGGGGCTG 
ATGTCCAGTG GCATGAGCCA GTTGATTGGG CTGAAGGAAA AGGGCCTGCC ACAAATTGCC 
CGCCTCCTGC AATCTGGCAA CTCTGATGTG GTGCGGTCCG GAGCCTCCCT CCTGAGCAAC 
ATGTCCCGCC ACCCTCTGCT GCACAGAGTG ATGGGGAACC AGGTGTTCCC GGAGGTGACC 
AGGCTCCTCA CCAGCCACAC TGGCAATACC AGCAACTCCG AAGACATCTT GTCCTCGGCC 
TGCTACACTG TGAGGAACCT GATGGCCTCG CAGCCACAAC TGGCCAAGCA GTACTTCTCC 
AGCAGCATGC TCAACAACAT CATCAACCTG TGCCGAAGCA GTGCCTCACC CAAGGCCGCA 
GAAGCTGCCC GGCTTCTCCT GTCTGACATG TGGTCCAGCA AGGAACTGCA GGGTGTCCTC 
AGACAGCAAG GTTTCGATAG GAACATGCTG GGAACCTTAG CTGGGGCCAA CAGCCTCAGG 
AACTTCACCT CCCGATTCTA A

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

PKP1 ( NM_001005337.3 ) cDNA ORF clone, Homo sapiens(human) -> NP_001005337.1 Homo sapiens plakophilin 1 (PKP1), transcript variant 1a, mRNA.

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CloneID	OHu28333
Clone ID Related Accession (Same CDS sequence)	NM_001005337.2 , NM_001005337.3
Accession Version	NM_001005337.3 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 2181bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-12-03
Organism	Homo sapiens(human)
Product	plakophilin-1 isoform 1a
Comment	Comment: REVIEWED REFSEQ: This record has been curated by NCBI staff. The reference sequence was derived from AC119427.3 and KF459531.1. On Jun 2, 2019 this sequence version replaced NM_001005337.2. Transcript Variant: This variant (1a) represents the shorter transcript variant as compared to variant 1b. It encodes the shorter protein (isoform 1a), compared to isoform 1b. Sequence Note: This RefSeq record was created from transcript and genomic sequence data to make the sequence consistent with the reference genome assembly. The genomic coordinates used for the transcript record were based on transcript alignments. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: BC114571.1, Z34974.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA1968832, SAMEA2142680 [ECO:0000348] ##Evidence-Data-END## ##RefSeq-Attributes-START## RefSeq Select criteria :: based on manual assertion, conservation, expression ##RefSeq-Attributes-END## COMPLETENESS: complete on the 3' end.

ATGAACCACT CGCCGCTCAA GACCGCCTTG GCGTACGAAT GCTTCCAGGA CCAGGACAAC 
TCCACGTTGG CTTTGCCGTC GGACCAAAAG ATGAAAACAG GCACGTCTGG CAGGCAGCGC 
GTGCAGGAGC AGGTGATGAT GACCGTCAAG CGGCAGAAGT CCAAGTCTTC CCAGTCGTCC 
ACCCTGAGCC ACTCCAATCG AGGTTCCATG TATGATGGCT TGGCTGACAA TTACAACTAT 
GGGACCACCA GCAGGAGCAG CTACTACTCC AAGTTCCAGG CAGGGAATGG CTCATGGGGA 
TATCCGATCT ACAATGGAAC CCTCAAGCGG GAGCCTGACA ACAGGCGCTT CAGCTCCTAC 
AGCCAGATGG AGAACTGGAG CCGGCACTAC CCCCGGGGCA GCTGTAACAC CACCGGCGCA 
GGCAGCGACA TCTGCTTCAT GCAGAAAATC AAGGCGAGCC GCAGTGAGCC CGACCTCTAC 
TGTGACCCAC GGGGCACCCT GCGCAAGGGC ACGCTGGGCA GCAAGGGCCA GAAGACCACC 
CAGAACCGCT ACAGCTTTTA CAGCACCTGC AGTGGTCAGA AGGCCATAAA GAAGTGCCCT 
GTGCGCCCGC CCTCTTGTGC CTCCAAGCAG GACCCTGTGT ATATCCCGCC CATCTCCTGC 
AACAAGGACC TGTCCTTTGG CCACTCTAGG GCCAGCTCCA AGATCTGCAG TGAGGACATC 
GAGTGCAGTG GGCTGACCAT CCCCAAGGCT GTGCAGTACC TGAGCTCCCA GGATGAGAAG 
TACCAGGCCA TTGGGGCCTA TTACATCCAG CATACCTGCT TCCAGGATGA ATCTGCCAAG 
CAACAGGTCT ATCAGCTGGG AGGCATCTGC AAGCTGGTGG ACCTCCTCCG CAGCCCCAAC 
CAGAACGTCC AGCAGGCCGC GGCAGGGGCC CTGCGCAACC TGGTGTTCAG GAGCACCACC 
AACAAGCTGG AGACCCGGAG GCAGAATGGG ATCCGCGAGG CAGTCAGCCT CCTGAGGAGA 
ACCGGGAACG CCGAGATCCA GAAGCAGCTG ACTGGGCTGC TCTGGAACCT GTCTTCCACT 
GACGAGCTGA AGGAGGAACT CATTGCCGAC GCCCTGCCTG TTCTGGCCGA CCGCGTCATC 
ATTCCCTTCT CTGGCTGGTG CGATGGCAAT AGCAACATGT CCCGGGAAGT GGTGGACCCT 
GAGGTCTTCT TCAATGCCAC AGGCTGCTTG AGGAACCTGA GCTCGGCCGA TGCAGGCCGC 
CAGACCATGC GTAACTACTC AGGGCTCATT GATTCCCTCA TGGCCTATGT CCAGAACTGT 
GTAGCGGCCA GCCGCTGTGA CGACAAGTCT GTGGAAAACT GCATGTGTGT TCTGCACAAC 
CTCTCCTACC GCCTGGACGC CGAGGTGCCC ACCCGCTACC GCCAGCTGGA GTATAACGCC 
CGCAACGCCT ACACCGAGAA GTCCTCCACT GGCTGCTTCA GCAACAAGAG CGACAAGATG 
ATGAACAACA ACTATGACTG CCCCCTGCCT GAGGAAGAGA CCAACCCCAA GGGCAGCGGC 
TGGTTGTACC ATTCAGATGC CATCCGCACC TACCTGAACC TCATGGGCAA GAGCAAGAAA 
GATGCTACCC TGGAGGCCTG TGCTGGTGCC CTGCAGAACC TGACAGCCAG CAAGGGGCTG 
ATGTCCAGTG GCATGAGCCA GTTGATTGGG CTGAAGGAAA AGGGCCTGCC ACAAATTGCC 
CGCCTCCTGC AATCTGGCAA CTCTGATGTG GTGCGGTCCG GAGCCTCCCT CCTGAGCAAC 
ATGTCCCGCC ACCCTCTGCT GCACAGAGTG ATGGGGAACC AGGTGTTCCC GGAGGTGACC 
AGGCTCCTCA CCAGCCACAC TGGCAATACC AGCAACTCCG AAGACATCTT GTCCTCGGCC 
TGCTACACTG TGAGGAACCT GATGGCCTCG CAGCCACAAC TGGCCAAGCA GTACTTCTCC 
AGCAGCATGC TCAACAACAT CATCAACCTG TGCCGAAGCA GTGCCTCACC CAAGGCCGCA 
GAAGCTGCCC GGCTTCTCCT GTCTGACATG TGGTCCAGCA AGGAACTGCA GGGTGTCCTC 
AGACAGCAAG GTTTCGATAG GAACATGCTG GGAACCTTAG CTGGGGCCAA CAGCCTCAGG 
AACTTCACCT CCCGATTCTA A

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_001005337.1
CDS	198..2378
Translation	MNHSPLKTALAYECFQDQDNSTLALPSDQKMKTGTSGRQRVQEQVMMTVKRQKSKSSQSSTLSHSNRGSMYDGLADNYNYGTTSRSSYYSKFQAGNGSWGYPIYNGTLKREPDNRRFSSYSQMENWSRHYPRGSCNTTGAGSDICFMQKIKASRSEPDLYCDPRGTLRKGTLGSKGQKTTQNRYSFYSTCSGQKAIKKCPVRPPSCASKQDPVYIPPISCNKDLSFGHSRASSKICSEDIECSGLTIPKAVQYLSSQDEKYQAIGAYYIQHTCFQDESAKQQVYQLGGICKLVDLLRSPNQNVQQAAAGALRNLVFRSTTNKLETRRQNGIREAVSLLRRTGNAEIQKQLTGLLWNLSSTDELKEELIADALPVLADRVIIPFSGWCDGNSNMSREVVDPEVFFNATGCLRNLSSADAGRQTMRNYSGLIDSLMAYVQNCVAASRCDDKSVENCMCVLHNLSYRLDAEVPTRYRQLEYNARNAYTEKSSTGCFSNKSDKMMNNNYDCPLPEEETNPKGSGWLYHSDAIRTYLNLMGKSKKDATLEACAGALQNLTASKGLMSSGMSQLIGLKEKGLPQIARLLQSGNSDVVRSGASLLSNMSRHPLLHRVMGNQVFPEVTRLLTSHTGNTSNSEDILSSACYTVRNLMASQPQLAKQYFSSSMLNNIINLCRSSASPKAAEAARLLLSDMWSSKELQGVLRQQGFDRNMLGTLAGANSLRNFTSRF

Target ORF information:

RefSeq Version	NM_001005337.3
Organism	Homo sapiens(human)
Definition	Homo sapiens plakophilin 1 (PKP1), transcript variant 1a, mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_001005337.3

ORF Insert Sequence:

ATGAACCACT CGCCGCTCAA GACCGCCTTG GCGTACGAAT GCTTCCAGGA CCAGGACAAC 
TCCACGTTGG CTTTGCCGTC GGACCAAAAG ATGAAAACAG GCACGTCTGG CAGGCAGCGC 
GTGCAGGAGC AGGTGATGAT GACCGTCAAG CGGCAGAAGT CCAAGTCTTC CCAGTCGTCC 
ACCCTGAGCC ACTCCAATCG AGGTTCCATG TATGATGGCT TGGCTGACAA TTACAACTAT 
GGGACCACCA GCAGGAGCAG CTACTACTCC AAGTTCCAGG CAGGGAATGG CTCATGGGGA 
TATCCGATCT ACAATGGAAC CCTCAAGCGG GAGCCTGACA ACAGGCGCTT CAGCTCCTAC 
AGCCAGATGG AGAACTGGAG CCGGCACTAC CCCCGGGGCA GCTGTAACAC CACCGGCGCA 
GGCAGCGACA TCTGCTTCAT GCAGAAAATC AAGGCGAGCC GCAGTGAGCC CGACCTCTAC 
TGTGACCCAC GGGGCACCCT GCGCAAGGGC ACGCTGGGCA GCAAGGGCCA GAAGACCACC 
CAGAACCGCT ACAGCTTTTA CAGCACCTGC AGTGGTCAGA AGGCCATAAA GAAGTGCCCT 
GTGCGCCCGC CCTCTTGTGC CTCCAAGCAG GACCCTGTGT ATATCCCGCC CATCTCCTGC 
AACAAGGACC TGTCCTTTGG CCACTCTAGG GCCAGCTCCA AGATCTGCAG TGAGGACATC 
GAGTGCAGTG GGCTGACCAT CCCCAAGGCT GTGCAGTACC TGAGCTCCCA GGATGAGAAG 
TACCAGGCCA TTGGGGCCTA TTACATCCAG CATACCTGCT TCCAGGATGA ATCTGCCAAG 
CAACAGGTCT ATCAGCTGGG AGGCATCTGC AAGCTGGTGG ACCTCCTCCG CAGCCCCAAC 
CAGAACGTCC AGCAGGCCGC GGCAGGGGCC CTGCGCAACC TGGTGTTCAG GAGCACCACC 
AACAAGCTGG AGACCCGGAG GCAGAATGGG ATCCGCGAGG CAGTCAGCCT CCTGAGGAGA 
ACCGGGAACG CCGAGATCCA GAAGCAGCTG ACTGGGCTGC TCTGGAACCT GTCTTCCACT 
GACGAGCTGA AGGAGGAACT CATTGCCGAC GCCCTGCCTG TTCTGGCCGA CCGCGTCATC 
ATTCCCTTCT CTGGCTGGTG CGATGGCAAT AGCAACATGT CCCGGGAAGT GGTGGACCCT 
GAGGTCTTCT TCAATGCCAC AGGCTGCTTG AGGAACCTGA GCTCGGCCGA TGCAGGCCGC 
CAGACCATGC GTAACTACTC AGGGCTCATT GATTCCCTCA TGGCCTATGT CCAGAACTGT 
GTAGCGGCCA GCCGCTGTGA CGACAAGTCT GTGGAAAACT GCATGTGTGT TCTGCACAAC 
CTCTCCTACC GCCTGGACGC CGAGGTGCCC ACCCGCTACC GCCAGCTGGA GTATAACGCC 
CGCAACGCCT ACACCGAGAA GTCCTCCACT GGCTGCTTCA GCAACAAGAG CGACAAGATG 
ATGAACAACA ACTATGACTG CCCCCTGCCT GAGGAAGAGA CCAACCCCAA GGGCAGCGGC 
TGGTTGTACC ATTCAGATGC CATCCGCACC TACCTGAACC TCATGGGCAA GAGCAAGAAA 
GATGCTACCC TGGAGGCCTG TGCTGGTGCC CTGCAGAACC TGACAGCCAG CAAGGGGCTG 
ATGTCCAGTG GCATGAGCCA GTTGATTGGG CTGAAGGAAA AGGGCCTGCC ACAAATTGCC 
CGCCTCCTGC AATCTGGCAA CTCTGATGTG GTGCGGTCCG GAGCCTCCCT CCTGAGCAAC 
ATGTCCCGCC ACCCTCTGCT GCACAGAGTG ATGGGGAACC AGGTGTTCCC GGAGGTGACC 
AGGCTCCTCA CCAGCCACAC TGGCAATACC AGCAACTCCG AAGACATCTT GTCCTCGGCC 
TGCTACACTG TGAGGAACCT GATGGCCTCG CAGCCACAAC TGGCCAAGCA GTACTTCTCC 
AGCAGCATGC TCAACAACAT CATCAACCTG TGCCGAAGCA GTGCCTCACC CAAGGCCGCA 
GAAGCTGCCC GGCTTCTCCT GTCTGACATG TGGTCCAGCA AGGAACTGCA GGGTGTCCTC 
AGACAGCAAG GTTTCGATAG GAACATGCTG GGAACCTTAG CTGGGGCCAA CAGCCTCAGG 
AACTTCACCT CCCGATTCTA A

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

PubMed

Plakophilin-1, a Novel Wnt Signaling Regulator, Is Critical for Tooth Development and Ameloblast Differentiation.
PloS one11(3)e0152206(2016)
Miyazaki K,Yoshizaki K,Arai C,Yamada A,Saito K,Ishikawa M,Xue H,Funada K,Haruyama N,Yamada Y,Fukumoto S,Takahashi I

Plakophilin 1-deficient cells upregulate SPOCK1: implications for prostate cancer progression.
Tumour biology : the journal of the International Society for Oncodevelopmental Biology and Medicine36(12)9567-77(2015 Dec)
Yang C,Fischer-Ke?o R,Schlechter T,Str?bel P,Marx A,Hofmann I

The nuclear localization pattern and interaction partners of GTF2IRD1 demonstrate a role in chromatin regulation.
Human genetics134(10)1099-115(2015 Oct)
Carmona-Mora P,Widagdo J,Tomasetig F,Canales CP,Cha Y,Lee W,Alshawaf A,Dottori M,Whan RM,Hardeman EC,Palmer SJ

Plakophilins 1 and 3 bind to FXR1 and thereby influence the mRNA stability of desmosomal proteins.
Molecular and cellular biology34(23)4244-56(2014 Dec)
Fischer-Ke?o R,Breuninger S,Hofmann S,Henn M,R?hrig T,Str?bel P,Stoecklin G,Hofmann I

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PKP1 cDNA ORF clone, Homo sapiens(human)

Gene

Clones

gRNAs

Related articles in PubMed

Target ORF information:

Target ORF information:

ORF Insert Sequence:

Target ORF information:

Target ORF information:

ORF Insert Sequence:

Target ORF information:

Target ORF information:

ORF Insert Sequence:

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