ACP2 cDNA ORF clone, Homo sapiens(human)

Gene
Clones
gRNAs

Summary

Gene Symbol	ACP2
Entrez Gene ID	53
Full Name	acid phosphatase 2, lysosomal
Synonyms	LAP
General protein information	Preferred Names acid phosphatase 2, lysosomal Names lysosomal acid phosphatase
Gene Type	protein-coding
Organism	Homo sapiens(human)
Genome	Chromosome: 11 Map Location: 11p11.2\|11p12-p11
Summary	The protein encoded by this gene belongs to the histidine acid phosphatase family, which hydrolyze orthophosphoric monoesters to alcohol and phosphate. This protein is localized to the lysosomal membrane, and is chemically and genetically distinct from the red cell acid phosphatase. Mice lacking this gene showed multiple defects, including bone structure alterations, lysosomal storage defects, and an increased tendency towards seizures. An enzymatically-inactive allele of this gene in mice showed severe growth retardation, hair-follicle abnormalities, and an ataxia-like phenotype. Alternatively spliced transcript variants have been found for this gene. A C-terminally extended isoform is also predicted to be produced by the use of an alternative in-frame translation termination codon via a stop codon readthrough mechanism. [provided by RefSeq, Oct 2017].
Disorder MIM:	171650
Disorder Html:	?Lysosomal acid phosphatase deficiency, 200950 (1)

mRNA and Protein(s)

mRNA	Protein	Name
NM_001357016.1	NP_001343945.1	lysosomal acid phosphatase isoform 1x precursor
NM_001610.3	NP_001601.1	lysosomal acid phosphatase isoform 1 precursor
NM_001302490.1	NP_001289419.1	lysosomal acid phosphatase isoform 4 precursor
NM_001302489.1	NP_001289418.1	lysosomal acid phosphatase isoform 3
NM_001302491.1	NP_001289420.1	lysosomal acid phosphatase isoform 5 precursor
NM_001302492.1	NP_001289421.1	lysosomal acid phosphatase isoform 6
NM_001610.4	NP_001601.1	lysosomal acid phosphatase isoform 1 precursor

Pathways from BioSystems

Homologies

Anopheles gambiae (African malaria mosquito)	AgaP_AGAP002387	XP_312568.5
Xenopus tropicalis (tropical clawed frog)	acp2	NP_001072207.1
Gallus gallus (chicken)	ACP2	NP_001026719.1
Drosophila melanogaster (fruit fly)	Acph-1	NP_524917.1
	ACP2	XP_001109604.1
Mus musculus (house mouse)	Acp2	NP_031413.1
Bos taurus (cattle)	ACP2	NP_001069526.1
Danio rerio (zebrafish)	acp2	NP_001013355.1
Caenorhabditis elegans (roundworm)	pho-5	NP_498604.2
Homo sapiens (human)	ACP2	NP_001601.1
Pan troglodytes (chimpanzee)	ACP2	NP_001233418.1
Canis lupus familiaris (dog)	ACP2	XP_850233.1
Rattus norvegicus (Norway rat)	Acp2	NP_058684.2

Gene Ontology
Bibliography

Related articles in PubMed

Lysosomal acid phosphatase 2 is an unfavorable prognostic factor but is associated with better survival in stage II colorectal cancer patients receiving chemotherapy.
Lee YC, Su CY, Lin YF, Lin CM, Fang CY, Lin YK, Hsiao M, Chen CL
Oncotarget8(7)12120-12132(2017 Feb)

Evidence of efficient stop codon readthrough in four mammalian genes.
Loughran G, Chou MY, Ivanov IP, Jungreis I, Kellis M, Kiran AM, Baranov PV, Atkins JF
Nucleic acids research42(14)8928-38(2014 Aug)

Mutation in the gene encoding lysosomal acid phosphatase (Acp2) causes cerebellum and skin malformation in mouse.
Mannan AU, Roussa E, Kraus C, Rickmann M, Maenner J, Nayernia K, Krieglstein K, Reis A, Engel W
Neurogenetics5(4)229-38(2004 Dec)

The tyrosine motifs of Lamp 1 and LAP determine their direct and indirect targetting to lysosomes.
Oberm?ller S, Kiecke C, von Figura K, H?ning S
Journal of cell science115(Pt 1)185-94(2002 Jan)

GeneRIFs: Gene References Into Functions What's a GeneRIF?

Data show that lysosomal acid phosphatase 2 (ACP2) was overexpressed in colorectal cancer (CRC) and associated with poor outcome in stage II CRC, and that high expression of ACP2 patients were more sensitive to chemotherapy than those with a low expression, suggesting ACP2 as a marker for CRC patients receiving chemotherapy.
Title: Lysosomal acid phosphatase 2 is an unfavorable prognostic factor but is associated with better survival in stage II colorectal cancer patients receiving chemotherapy.

Observational study of gene-disease association. (HuGE Navigator)
Title: Polymorphisms in mitochondrial genes and prostate cancer risk.

Genome-wide association study of gene-disease association. (HuGE Navigator)
Title: Identification of a novel risk locus for progressive supranuclear palsy by a pooled genomewide scan of 500,288 single-nucleotide polymorphisms.

An enzymatically inactive allele of mouse Acp2 causes cerebellum abnormalities, growth retardation, hair-follicle abnormalities, and an ataxia-like phenotype.
Title: Mutation in the gene encoding lysosomal acid phosphatase (Acp2) causes cerebellum and skin malformation in mouse.

LAP-deficient mice exhibit multiple defects including bone structure alterations, lysosomal storage defects in the kidneys and central nervous system, and an increased tendency towards seizures.
Title: Mice deficient in lysosomal acid phosphatase develop lysosomal storage in the kidney and central nervous system.

The following ACP2 gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the ACP2 cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1⁺/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.

***CloneID	Accession No.	Definition	**Vector	*Turnaround time	Price (USD)
OHu18106	NM_001610.4 Latest version!	Homo sapiens acid phosphatase 2, lysosomal (ACP2), transcript variant 1, mRNA.	pcDNA3.1-C-(k)DYK or customized vector	in pcDNA3.1-C-(k)DYK	$159.50-$223.30 $319.00
OHu44902	NM_001302492.1 Latest version!	Homo sapiens acid phosphatase 2, lysosomal (ACP2), transcript variant 6, mRNA.	pcDNA3.1-C-(k)DYK or customized vector	5-7	$139.30 $199.00
OHu103215	NM_001357016.1 Latest version!	Homo sapiens acid phosphatase 2, lysosomal (ACP2), transcript variant 1, mRNA.	pcDNA3.1-C-(k)DYK or customized vector	7-9	$223.30 $319.00
OHu56125	NM_001302491.1 Latest version!	Homo sapiens acid phosphatase 2, lysosomal (ACP2), transcript variant 5, mRNA.	pcDNA3.1-C-(k)DYK or customized vector	7-9	$223.30 $319.00
OHu56126	NM_001302490.1 Latest version!	Homo sapiens acid phosphatase 2, lysosomal (ACP2), transcript variant 4, mRNA.	pcDNA3.1-C-(k)DYK or customized vector	7-9	$223.30 $319.00
OHu56127	NM_001302489.1 Latest version!	Homo sapiens acid phosphatase 2, lysosomal (ACP2), transcript variant 3, mRNA.	pcDNA3.1-C-(k)DYK or customized vector	7-9	$223.30 $319.00
View Old Accession Versions >>
OHu18106	NM_001610.3	Homo sapiens acid phosphatase 2, lysosomal (ACP2), transcript variant 1, mRNA.	pcDNA3.1-C-(k)DYK or customized vector	in pcDNA3.1-C-(k)DYK	$159.50-$223.30 $319.00
Hide Old Accession Versions >>

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***One clone ID might be correlated to multiple accession numbers, which share the same CDS sequence.

Reference Sequences (Refseq)

ACP2 ( NM_001610.3 ) cDNA ORF clone, Homo sapiens(human) -> NP_001601.1 Homo sapiens acid phosphatase 2, lysosomal (ACP2), transcript variant 1, mRNA.

Price & Availability↑

CloneID	OHu18106
Clone ID Related Accession (Same CDS sequence)	NM_001610.3 , NM_001610.4
Accession Version	NM_001610.3	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 1272bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2017-10-15
Organism	Homo sapiens(human)
Product	lysosomal acid phosphatase isoform 1 precursor
Comment	Comment: REVIEWED REFSEQ: This record has been curated by NCBI staff. The reference sequence was derived from DC337294.1, BC093010.1 and AK308512.1. This sequence is a reference standard in the RefSeqGene project. On Oct 25, 2014 this sequence version replaced NM_001610.2. Transcript Variant: This variant (1) represents the predominant transcript and encodes two isoforms, which result from the use of alternative in-frame translation termination codons. The shorter isoform (1) results from translation termination at the upstream UGA stop codon, while the longer isoform (1x) results from UGA stop codon readthrough to the downstream UAG termination codon. This RefSeq represents the shorter isoform (1). Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: BC093010.1, SRR1803613.101594.1 [ECO:0000332] RNAseq introns :: mixed/partial sample support SAMEA1965299, SAMEA1966682 [ECO:0000350] ##Evidence-Data-END## COMPLETENESS: full length.

ATGGCGGGCA AGCGGTCCGG CTGGAGCCGG GCGGCTCTCC TCCAGCTCCT TCTCGGCGTG 
AACCTGGTGG TGATGCCGCC CACCCGGGCC CGGAGTCTGC GCTTCGTTAC CTTGCTGTAC 
CGCCATGGAG ACCGTTCACC AGTGAAGACA TATCCCAAGG ACCCCTATCA GGAAGAAGAA 
TGGCCCCAGG GGTTTGGTCA GTTAACCAAG GAGGGGATGC TACAGCACTG GGAACTGGGC 
CAGGCCCTGC GGCAGCGCTA TCACGGCTTC CTAAACACCT CTTATCACCG GCAAGAGGTT 
TATGTGCGAA GCACAGACTT TGACCGGACT CTCATGAGTG CTGAGGCCAA CCTGGCTGGA 
CTCTTCCCTC CCAACGGGAT GCAGCGCTTC AACCCGAACA TCTCGTGGCA GCCTATTCCT 
GTGCACACTG TGCCCATCAC TGAGGACAGG CTGCTGAAGT TCCCGTTGGG CCCATGTCCC 
CGTTATGAGC AGCTGCAGAA CGAGACCCGG CAGACACCAG AGTATCAGAA TGAGAGTTCT 
CGGAATGCAC AATTTCTGGA CATGGTGGCC AACGAGACAG GGCTTACAGA CCTGACACTG 
GAGACCGTCT GGAATGTCTA TGACACACTC TTCTGTGAGC AAACGCACGG GCTGCGCCTG 
CCGCCCTGGG CCTCACCCCA AACCATGCAG CGTCTCAGCC GGCTAAAGGA CTTCAGCTTC 
CGCTTCCTCT TCGGAATCTA CCAGCAGGCG GAGAAGGCCC GGCTTCAGGG GGGAGTCCTG 
CTGGCTCAGA TAAGGAAGAA CCTGACCCTA ATGGCGACCA CCTCCCAGCT CCCCAAGCTG 
CTGGTTTACT CTGCGCACGA CACTACCCTG GTTGCCCTGC AAATGGCACT GGATGTCTAC 
AATGGTGAAC AAGCCCCCTA CGCCTCCTGC CACATATTTG AACTGTACCA GGAAGATTCT 
GGGAATTTCT CAGTGGAGAT GTACTTTCGG AACGAGAGTG ACAAGGCCCC CTGGCCGCTC 
AGCCTGCCTG GCTGCCCTCA CCGCTGCCCA CTGCAGGACT TCCTTCGCCT CACAGAGCCC 
GTCGTGCCCA AGGATTGGCA GCAGGAGTGC CAGCTGGCAA GCGGTCCTGC AGACACAGAG 
GTGATTGTGG CCTTGGCTGT ATGTGGCTCC ATCCTCTTCC TCCTCATAGT GCTGCTCCTC 
ACCGTCCTCT TCCGGATGCA GGCCCAGCCT CCTGGCTACC GCCACGTCGC AGATGGGGAG 
GACCACGCCT GA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_001601.1
CDS	59..1330
Translation	MAGKRSGWSRAALLQLLLGVNLVVMPPTRARSLRFVTLLYRHGDRSPVKTYPKDPYQEEEWPQGFGQLTKEGMLQHWELGQALRQRYHGFLNTSYHRQEVYVRSTDFDRTLMSAEANLAGLFPPNGMQRFNPNISWQPIPVHTVPITEDRLLKFPLGPCPRYEQLQNETRQTPEYQNESSRNAQFLDMVANETGLTDLTLETVWNVYDTLFCEQTHGLRLPPWASPQTMQRLSRLKDFSFRFLFGIYQQAEKARLQGGVLLAQIRKNLTLMATTSQLPKLLVYSAHDTTLVALQMALDVYNGEQAPYASCHIFELYQEDSGNFSVEMYFRNESDKAPWPLSLPGCPHRCPLQDFLRLTEPVVPKDWQQECQLASGPADTEVIVALAVCGSILFLLIVLLLTVLFRMQAQPPGYRHVADGEDHA

Target ORF information:

RefSeq Version	NM_001610.3
Organism	Homo sapiens(human)
Definition	Homo sapiens acid phosphatase 2, lysosomal (ACP2), transcript variant 1, mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_001610.3

ORF Insert Sequence:

ATGGCGGGCA AGCGGTCCGG CTGGAGCCGG GCGGCTCTCC TCCAGCTCCT TCTCGGCGTG 
AACCTGGTGG TGATGCCGCC CACCCGGGCC CGGAGTCTGC GCTTCGTTAC CTTGCTGTAC 
CGCCATGGAG ACCGTTCACC AGTGAAGACA TATCCCAAGG ACCCCTATCA GGAAGAAGAA 
TGGCCCCAGG GGTTTGGTCA GTTAACCAAG GAGGGGATGC TACAGCACTG GGAACTGGGC 
CAGGCCCTGC GGCAGCGCTA TCACGGCTTC CTAAACACCT CTTATCACCG GCAAGAGGTT 
TATGTGCGAA GCACAGACTT TGACCGGACT CTCATGAGTG CTGAGGCCAA CCTGGCTGGA 
CTCTTCCCTC CCAACGGGAT GCAGCGCTTC AACCCGAACA TCTCGTGGCA GCCTATTCCT 
GTGCACACTG TGCCCATCAC TGAGGACAGG CTGCTGAAGT TCCCGTTGGG CCCATGTCCC 
CGTTATGAGC AGCTGCAGAA CGAGACCCGG CAGACACCAG AGTATCAGAA TGAGAGTTCT 
CGGAATGCAC AATTTCTGGA CATGGTGGCC AACGAGACAG GGCTTACAGA CCTGACACTG 
GAGACCGTCT GGAATGTCTA TGACACACTC TTCTGTGAGC AAACGCACGG GCTGCGCCTG 
CCGCCCTGGG CCTCACCCCA AACCATGCAG CGTCTCAGCC GGCTAAAGGA CTTCAGCTTC 
CGCTTCCTCT TCGGAATCTA CCAGCAGGCG GAGAAGGCCC GGCTTCAGGG GGGAGTCCTG 
CTGGCTCAGA TAAGGAAGAA CCTGACCCTA ATGGCGACCA CCTCCCAGCT CCCCAAGCTG 
CTGGTTTACT CTGCGCACGA CACTACCCTG GTTGCCCTGC AAATGGCACT GGATGTCTAC 
AATGGTGAAC AAGCCCCCTA CGCCTCCTGC CACATATTTG AACTGTACCA GGAAGATTCT 
GGGAATTTCT CAGTGGAGAT GTACTTTCGG AACGAGAGTG ACAAGGCCCC CTGGCCGCTC 
AGCCTGCCTG GCTGCCCTCA CCGCTGCCCA CTGCAGGACT TCCTTCGCCT CACAGAGCCC 
GTCGTGCCCA AGGATTGGCA GCAGGAGTGC CAGCTGGCAA GCGGTCCTGC AGACACAGAG 
GTGATTGTGG CCTTGGCTGT ATGTGGCTCC ATCCTCTTCC TCCTCATAGT GCTGCTCCTC 
ACCGTCCTCT TCCGGATGCA GGCCCAGCCT CCTGGCTACC GCCACGTCGC AGATGGGGAG 
GACCACGCCT GA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

ACP2 ( NM_001610.4 ) cDNA ORF clone, Homo sapiens(human) -> NP_001601.1 Homo sapiens acid phosphatase 2, lysosomal (ACP2), transcript variant 1, mRNA.

Price & Availability↑

CloneID	OHu18106
Clone ID Related Accession (Same CDS sequence)	NM_001610.3 , NM_001610.4
Accession Version	NM_001610.4 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 1272bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-12-30
Organism	Homo sapiens(human)
Product	lysosomal acid phosphatase isoform 1 precursor
Comment	Comment: REVIEWED REFSEQ: This record has been curated by NCBI staff. The reference sequence was derived from AC018410.24. On Nov 22, 2018 this sequence version replaced NM_001610.3. Transcript Variant: This variant (1) represents the predominant transcript and encodes two isoforms, which result from the use of alternative in-frame translation termination codons. The shorter isoform (1) results from translation termination at the upstream UGA stop codon, while the longer isoform (1x) results from UGA stop codon readthrough to the downstream UAG termination codon. This RefSeq represents the shorter isoform (1). Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: SRR1803612.217855.1, SRR3476690.646611.1 [ECO:0000332] RNAseq introns :: mixed/partial sample support SAMEA1965299, SAMEA1966682 [ECO:0000350] ##Evidence-Data-END## ##RefSeq-Attributes-START## MANE Ensembl match :: ENST00000672073.1/ ENSP00000500291.1 RefSeq Select criteria :: based on conservation, expression, longest protein ##RefSeq-Attributes-END## COMPLETENESS: full length.

ATGGCGGGCA AGCGGTCCGG CTGGAGCCGG GCGGCTCTCC TCCAGCTCCT TCTCGGCGTG 
AACCTGGTGG TGATGCCGCC CACCCGGGCC CGGAGTCTGC GCTTCGTTAC CTTGCTGTAC 
CGCCATGGAG ACCGTTCACC AGTGAAGACA TATCCCAAGG ACCCCTATCA GGAAGAAGAA 
TGGCCCCAGG GGTTTGGTCA GTTAACCAAG GAGGGGATGC TACAGCACTG GGAACTGGGC 
CAGGCCCTGC GGCAGCGCTA TCACGGCTTC CTAAACACCT CTTATCACCG GCAAGAGGTT 
TATGTGCGAA GCACAGACTT TGACCGGACT CTCATGAGTG CTGAGGCCAA CCTGGCTGGA 
CTCTTCCCTC CCAACGGGAT GCAGCGCTTC AACCCGAACA TCTCGTGGCA GCCTATTCCT 
GTGCACACTG TGCCCATCAC TGAGGACAGG CTGCTGAAGT TCCCGTTGGG CCCATGTCCC 
CGTTATGAGC AGCTGCAGAA CGAGACCCGG CAGACACCAG AGTATCAGAA TGAGAGTTCT 
CGGAATGCAC AATTTCTGGA CATGGTGGCC AACGAGACAG GGCTTACAGA CCTGACACTG 
GAGACCGTCT GGAATGTCTA TGACACACTC TTCTGTGAGC AAACGCACGG GCTGCGCCTG 
CCGCCCTGGG CCTCACCCCA AACCATGCAG CGTCTCAGCC GGCTAAAGGA CTTCAGCTTC 
CGCTTCCTCT TCGGAATCTA CCAGCAGGCG GAGAAGGCCC GGCTTCAGGG GGGAGTCCTG 
CTGGCTCAGA TAAGGAAGAA CCTGACCCTA ATGGCGACCA CCTCCCAGCT CCCCAAGCTG 
CTGGTTTACT CTGCGCACGA CACTACCCTG GTTGCCCTGC AAATGGCACT GGATGTCTAC 
AATGGTGAAC AAGCCCCCTA CGCCTCCTGC CACATATTTG AACTGTACCA GGAAGATTCT 
GGGAATTTCT CAGTGGAGAT GTACTTTCGG AACGAGAGTG ACAAGGCCCC CTGGCCGCTC 
AGCCTGCCTG GCTGCCCTCA CCGCTGCCCA CTGCAGGACT TCCTTCGCCT CACAGAGCCC 
GTCGTGCCCA AGGATTGGCA GCAGGAGTGC CAGCTGGCAA GCGGTCCTGC AGACACAGAG 
GTGATTGTGG CCTTGGCTGT ATGTGGCTCC ATCCTCTTCC TCCTCATAGT GCTGCTCCTC 
ACCGTCCTCT TCCGGATGCA GGCCCAGCCT CCTGGCTACC GCCACGTCGC AGATGGGGAG 
GACCACGCCT GA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_001601.1
CDS	26..1297
Translation	MAGKRSGWSRAALLQLLLGVNLVVMPPTRARSLRFVTLLYRHGDRSPVKTYPKDPYQEEEWPQGFGQLTKEGMLQHWELGQALRQRYHGFLNTSYHRQEVYVRSTDFDRTLMSAEANLAGLFPPNGMQRFNPNISWQPIPVHTVPITEDRLLKFPLGPCPRYEQLQNETRQTPEYQNESSRNAQFLDMVANETGLTDLTLETVWNVYDTLFCEQTHGLRLPPWASPQTMQRLSRLKDFSFRFLFGIYQQAEKARLQGGVLLAQIRKNLTLMATTSQLPKLLVYSAHDTTLVALQMALDVYNGEQAPYASCHIFELYQEDSGNFSVEMYFRNESDKAPWPLSLPGCPHRCPLQDFLRLTEPVVPKDWQQECQLASGPADTEVIVALAVCGSILFLLIVLLLTVLFRMQAQPPGYRHVADGEDHA

Target ORF information:

RefSeq Version	NM_001610.4
Organism	Homo sapiens(human)
Definition	Homo sapiens acid phosphatase 2, lysosomal (ACP2), transcript variant 1, mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_001610.4

ORF Insert Sequence:

ATGGCGGGCA AGCGGTCCGG CTGGAGCCGG GCGGCTCTCC TCCAGCTCCT TCTCGGCGTG 
AACCTGGTGG TGATGCCGCC CACCCGGGCC CGGAGTCTGC GCTTCGTTAC CTTGCTGTAC 
CGCCATGGAG ACCGTTCACC AGTGAAGACA TATCCCAAGG ACCCCTATCA GGAAGAAGAA 
TGGCCCCAGG GGTTTGGTCA GTTAACCAAG GAGGGGATGC TACAGCACTG GGAACTGGGC 
CAGGCCCTGC GGCAGCGCTA TCACGGCTTC CTAAACACCT CTTATCACCG GCAAGAGGTT 
TATGTGCGAA GCACAGACTT TGACCGGACT CTCATGAGTG CTGAGGCCAA CCTGGCTGGA 
CTCTTCCCTC CCAACGGGAT GCAGCGCTTC AACCCGAACA TCTCGTGGCA GCCTATTCCT 
GTGCACACTG TGCCCATCAC TGAGGACAGG CTGCTGAAGT TCCCGTTGGG CCCATGTCCC 
CGTTATGAGC AGCTGCAGAA CGAGACCCGG CAGACACCAG AGTATCAGAA TGAGAGTTCT 
CGGAATGCAC AATTTCTGGA CATGGTGGCC AACGAGACAG GGCTTACAGA CCTGACACTG 
GAGACCGTCT GGAATGTCTA TGACACACTC TTCTGTGAGC AAACGCACGG GCTGCGCCTG 
CCGCCCTGGG CCTCACCCCA AACCATGCAG CGTCTCAGCC GGCTAAAGGA CTTCAGCTTC 
CGCTTCCTCT TCGGAATCTA CCAGCAGGCG GAGAAGGCCC GGCTTCAGGG GGGAGTCCTG 
CTGGCTCAGA TAAGGAAGAA CCTGACCCTA ATGGCGACCA CCTCCCAGCT CCCCAAGCTG 
CTGGTTTACT CTGCGCACGA CACTACCCTG GTTGCCCTGC AAATGGCACT GGATGTCTAC 
AATGGTGAAC AAGCCCCCTA CGCCTCCTGC CACATATTTG AACTGTACCA GGAAGATTCT 
GGGAATTTCT CAGTGGAGAT GTACTTTCGG AACGAGAGTG ACAAGGCCCC CTGGCCGCTC 
AGCCTGCCTG GCTGCCCTCA CCGCTGCCCA CTGCAGGACT TCCTTCGCCT CACAGAGCCC 
GTCGTGCCCA AGGATTGGCA GCAGGAGTGC CAGCTGGCAA GCGGTCCTGC AGACACAGAG 
GTGATTGTGG CCTTGGCTGT ATGTGGCTCC ATCCTCTTCC TCCTCATAGT GCTGCTCCTC 
ACCGTCCTCT TCCGGATGCA GGCCCAGCCT CCTGGCTACC GCCACGTCGC AGATGGGGAG 
GACCACGCCT GA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

ACP2 ( NM_001302492.1 ) cDNA ORF clone, Homo sapiens(human) -> NP_001289421.1 Homo sapiens acid phosphatase 2, lysosomal (ACP2), transcript variant 6, mRNA.

Price & Availability↑

CloneID	OHu44902
Clone ID Related Accession (Same CDS sequence)	NM_001302492.1
Accession Version	NM_001302492.1 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 711bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-08-05
Organism	Homo sapiens(human)
Product	lysosomal acid phosphatase isoform 6
Comment	Comment: REVIEWED REFSEQ: This record has been curated by NCBI staff. The reference sequence was derived from DC337294.1, AK303894.1, AK300569.1, BC093010.1 and AK308512.1. On Oct 25, 2014 this sequence version replaced XM_005252984.2. Transcript Variant: This variant (6) lacks an internal exon and uses an alternate acceptor splice site in the 5' region compared to variant 1. These differences result in translation initiation at an in-frame downstream start codon compared to variant 1. The encoded isoform (6) has a shorter N-terminus compared to isoform 1. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: SRR1803611.175561.1, SRR1803614.75472.1 [ECO:0000332] RNAseq introns :: mixed/partial sample support SAMEA1965299, SAMEA1966682 [ECO:0000350] ##Evidence-Data-END## COMPLETENESS: full length.

ATGGTGGCCA ACGAGACAGG GCTTACAGAC CTGACACTGG AGACCGTCTG GAATGTCTAT 
GACACACTCT TCTGTGAGCA AACGCACGGG CTGCGCCTGC CGCCCTGGGC CTCACCCCAA 
ACCATGCAGC GTCTCAGCCG GCTAAAGGAC TTCAGCTTCC GCTTCCTCTT CGGAATCTAC 
CAGCAGGCGG AGAAGGCCCG GCTTCAGGGG GGAGTCCTGC TGGCTCAGAT AAGGAAGAAC 
CTGACCCTAA TGGCGACCAC CTCCCAGCTC CCCAAGCTGC TGGTTTACTC TGCGCACGAC 
ACTACCCTGG TTGCCCTGCA AATGGCACTG GATGTCTACA ATGGTGAACA AGCCCCCTAC 
GCCTCCTGCC ACATATTTGA ACTGTACCAG GAAGATTCTG GGAATTTCTC AGTGGAGATG 
TACTTTCGGA ACGAGAGTGA CAAGGCCCCC TGGCCGCTCA GCCTGCCTGG CTGCCCTCAC 
CGCTGCCCAC TGCAGGACTT CCTTCGCCTC ACAGAGCCCG TCGTGCCCAA GGATTGGCAG 
CAGGAGTGCC AGCTGGCAAG CGGTCCTGCA GACACAGAGG TGATTGTGGC CTTGGCTGTA 
TGTGGCTCCA TCCTCTTCCT CCTCATAGTG CTGCTCCTCA CCGTCCTCTT CCGGATGCAG 
GCCCAGCCTC CTGGCTACCG CCACGTCGCA GATGGGGAGG ACCACGCCTG A

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_001289421.1
CDS	549..1259
Translation	MVANETGLTDLTLETVWNVYDTLFCEQTHGLRLPPWASPQTMQRLSRLKDFSFRFLFGIYQQAEKARLQGGVLLAQIRKNLTLMATTSQLPKLLVYSAHDTTLVALQMALDVYNGEQAPYASCHIFELYQEDSGNFSVEMYFRNESDKAPWPLSLPGCPHRCPLQDFLRLTEPVVPKDWQQECQLASGPADTEVIVALAVCGSILFLLIVLLLTVLFRMQAQPPGYRHVADGEDHA

Target ORF information:

RefSeq Version	NM_001302492.1
Organism	Homo sapiens(human)
Definition	Homo sapiens acid phosphatase 2, lysosomal (ACP2), transcript variant 6, mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_001302492.1

ORF Insert Sequence:

ATGGTGGCCA ACGAGACAGG GCTTACAGAC CTGACACTGG AGACCGTCTG GAATGTCTAT 
GACACACTCT TCTGTGAGCA AACGCACGGG CTGCGCCTGC CGCCCTGGGC CTCACCCCAA 
ACCATGCAGC GTCTCAGCCG GCTAAAGGAC TTCAGCTTCC GCTTCCTCTT CGGAATCTAC 
CAGCAGGCGG AGAAGGCCCG GCTTCAGGGG GGAGTCCTGC TGGCTCAGAT AAGGAAGAAC 
CTGACCCTAA TGGCGACCAC CTCCCAGCTC CCCAAGCTGC TGGTTTACTC TGCGCACGAC 
ACTACCCTGG TTGCCCTGCA AATGGCACTG GATGTCTACA ATGGTGAACA AGCCCCCTAC 
GCCTCCTGCC ACATATTTGA ACTGTACCAG GAAGATTCTG GGAATTTCTC AGTGGAGATG 
TACTTTCGGA ACGAGAGTGA CAAGGCCCCC TGGCCGCTCA GCCTGCCTGG CTGCCCTCAC 
CGCTGCCCAC TGCAGGACTT CCTTCGCCTC ACAGAGCCCG TCGTGCCCAA GGATTGGCAG 
CAGGAGTGCC AGCTGGCAAG CGGTCCTGCA GACACAGAGG TGATTGTGGC CTTGGCTGTA 
TGTGGCTCCA TCCTCTTCCT CCTCATAGTG CTGCTCCTCA CCGTCCTCTT CCGGATGCAG 
GCCCAGCCTC CTGGCTACCG CCACGTCGCA GATGGGGAGG ACCACGCCTG A

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

ACP2 ( NM_001357016.1 ) cDNA ORF clone, Homo sapiens(human) -> NP_001343945.1 Homo sapiens acid phosphatase 2, lysosomal (ACP2), transcript variant 1, mRNA.

Price & Availability↑

CloneID	OHu103215
Clone ID Related Accession (Same CDS sequence)	NM_001357016.1
Accession Version	NM_001357016.1 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 1305bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-08-05
Organism	Homo sapiens(human)
Product	lysosomal acid phosphatase isoform 1x precursor
Comment	Comment: REVIEWED REFSEQ: This record has been curated by NCBI staff. The reference sequence was derived from DC337294.1, BC093010.1 and AK308512.1. Transcript Variant: This variant (1) represents the predominant transcript and encodes two isoforms, which result from the use of alternative in-frame translation termination codons. The shorter isoform (1) results from translation termination at the upstream UGA stop codon, while the longer isoform (1x) results from UGA stop codon readthrough to the downstream UAG termination codon. This RefSeq represents the longer isoform (1x). As the UGA stop codon has been reported to specify several alternative amino acids (tryptophan, cysteine, arginine and serine), its location in the longer isoform is denoted by an 'X'. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: BC093010.1, SRR1803613.101594.1 [ECO:0000332] RNAseq introns :: mixed/partial sample support SAMEA1965299, SAMEA1966682 [ECO:0000350] ##Evidence-Data-END## ##RefSeq-Attributes-START## stop codon readthrough :: inferred from conservation ##RefSeq-Attributes-END## COMPLETENESS: full length.

ATGGCGGGCA AGCGGTCCGG CTGGAGCCGG GCGGCTCTCC TCCAGCTCCT TCTCGGCGTG 
AACCTGGTGG TGATGCCGCC CACCCGGGCC CGGAGTCTGC GCTTCGTTAC CTTGCTGTAC 
CGCCATGGAG ACCGTTCACC AGTGAAGACA TATCCCAAGG ACCCCTATCA GGAAGAAGAA 
TGGCCCCAGG GGTTTGGTCA GTTAACCAAG GAGGGGATGC TACAGCACTG GGAACTGGGC 
CAGGCCCTGC GGCAGCGCTA TCACGGCTTC CTAAACACCT CTTATCACCG GCAAGAGGTT 
TATGTGCGAA GCACAGACTT TGACCGGACT CTCATGAGTG CTGAGGCCAA CCTGGCTGGA 
CTCTTCCCTC CCAACGGGAT GCAGCGCTTC AACCCGAACA TCTCGTGGCA GCCTATTCCT 
GTGCACACTG TGCCCATCAC TGAGGACAGG CTGCTGAAGT TCCCGTTGGG CCCATGTCCC 
CGTTATGAGC AGCTGCAGAA CGAGACCCGG CAGACACCAG AGTATCAGAA TGAGAGTTCT 
CGGAATGCAC AATTTCTGGA CATGGTGGCC AACGAGACAG GGCTTACAGA CCTGACACTG 
GAGACCGTCT GGAATGTCTA TGACACACTC TTCTGTGAGC AAACGCACGG GCTGCGCCTG 
CCGCCCTGGG CCTCACCCCA AACCATGCAG CGTCTCAGCC GGCTAAAGGA CTTCAGCTTC 
CGCTTCCTCT TCGGAATCTA CCAGCAGGCG GAGAAGGCCC GGCTTCAGGG GGGAGTCCTG 
CTGGCTCAGA TAAGGAAGAA CCTGACCCTA ATGGCGACCA CCTCCCAGCT CCCCAAGCTG 
CTGGTTTACT CTGCGCACGA CACTACCCTG GTTGCCCTGC AAATGGCACT GGATGTCTAC 
AATGGTGAAC AAGCCCCCTA CGCCTCCTGC CACATATTTG AACTGTACCA GGAAGATTCT 
GGGAATTTCT CAGTGGAGAT GTACTTTCGG AACGAGAGTG ACAAGGCCCC CTGGCCGCTC 
AGCCTGCCTG GCTGCCCTCA CCGCTGCCCA CTGCAGGACT TCCTTCGCCT CACAGAGCCC 
GTCGTGCCCA AGGATTGGCA GCAGGAGTGC CAGCTGGCAA GCGGTCCTGC AGACACAGAG 
GTGATTGTGG CCTTGGCTGT ATGTGGCTCC ATCCTCTTCC TCCTCATAGT GCTGCTCCTC 
ACCGTCCTCT TCCGGATGCA GGCCCAGCCT CCTGGCTACC GCCACGTCGC AGATGGGGAG 
GACCACGCCT GACAACCACT CAGCCCCCTT CCCTCCACCT CCTAG

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_001343945.1
CDS	59..1363
Translation	MAGKRSGWSRAALLQLLLGVNLVVMPPTRARSLRFVTLLYRHGDRSPVKTYPKDPYQEEEWPQGFGQLTKEGMLQHWELGQALRQRYHGFLNTSYHRQEVYVRSTDFDRTLMSAEANLAGLFPPNGMQRFNPNISWQPIPVHTVPITEDRLLKFPLGPCPRYEQLQNETRQTPEYQNESSRNAQFLDMVANETGLTDLTLETVWNVYDTLFCEQTHGLRLPPWASPQTMQRLSRLKDFSFRFLFGIYQQAEKARLQGGVLLAQIRKNLTLMATTSQLPKLLVYSAHDTTLVALQMALDVYNGEQAPYASCHIFELYQEDSGNFSVEMYFRNESDKAPWPLSLPGCPHRCPLQDFLRLTEPVVPKDWQQECQLASGPADTEVIVALAVCGSILFLLIVLLLTVLFRMQAQPPGYRHVADGEDHA*QPLSPLPSTS

Target ORF information:

RefSeq Version	NM_001357016.1
Organism	Homo sapiens(human)
Definition	Homo sapiens acid phosphatase 2, lysosomal (ACP2), transcript variant 1, mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_001357016.1

ORF Insert Sequence:

ATGGCGGGCA AGCGGTCCGG CTGGAGCCGG GCGGCTCTCC TCCAGCTCCT TCTCGGCGTG 
AACCTGGTGG TGATGCCGCC CACCCGGGCC CGGAGTCTGC GCTTCGTTAC CTTGCTGTAC 
CGCCATGGAG ACCGTTCACC AGTGAAGACA TATCCCAAGG ACCCCTATCA GGAAGAAGAA 
TGGCCCCAGG GGTTTGGTCA GTTAACCAAG GAGGGGATGC TACAGCACTG GGAACTGGGC 
CAGGCCCTGC GGCAGCGCTA TCACGGCTTC CTAAACACCT CTTATCACCG GCAAGAGGTT 
TATGTGCGAA GCACAGACTT TGACCGGACT CTCATGAGTG CTGAGGCCAA CCTGGCTGGA 
CTCTTCCCTC CCAACGGGAT GCAGCGCTTC AACCCGAACA TCTCGTGGCA GCCTATTCCT 
GTGCACACTG TGCCCATCAC TGAGGACAGG CTGCTGAAGT TCCCGTTGGG CCCATGTCCC 
CGTTATGAGC AGCTGCAGAA CGAGACCCGG CAGACACCAG AGTATCAGAA TGAGAGTTCT 
CGGAATGCAC AATTTCTGGA CATGGTGGCC AACGAGACAG GGCTTACAGA CCTGACACTG 
GAGACCGTCT GGAATGTCTA TGACACACTC TTCTGTGAGC AAACGCACGG GCTGCGCCTG 
CCGCCCTGGG CCTCACCCCA AACCATGCAG CGTCTCAGCC GGCTAAAGGA CTTCAGCTTC 
CGCTTCCTCT TCGGAATCTA CCAGCAGGCG GAGAAGGCCC GGCTTCAGGG GGGAGTCCTG 
CTGGCTCAGA TAAGGAAGAA CCTGACCCTA ATGGCGACCA CCTCCCAGCT CCCCAAGCTG 
CTGGTTTACT CTGCGCACGA CACTACCCTG GTTGCCCTGC AAATGGCACT GGATGTCTAC 
AATGGTGAAC AAGCCCCCTA CGCCTCCTGC CACATATTTG AACTGTACCA GGAAGATTCT 
GGGAATTTCT CAGTGGAGAT GTACTTTCGG AACGAGAGTG ACAAGGCCCC CTGGCCGCTC 
AGCCTGCCTG GCTGCCCTCA CCGCTGCCCA CTGCAGGACT TCCTTCGCCT CACAGAGCCC 
GTCGTGCCCA AGGATTGGCA GCAGGAGTGC CAGCTGGCAA GCGGTCCTGC AGACACAGAG 
GTGATTGTGG CCTTGGCTGT ATGTGGCTCC ATCCTCTTCC TCCTCATAGT GCTGCTCCTC 
ACCGTCCTCT TCCGGATGCA GGCCCAGCCT CCTGGCTACC GCCACGTCGC AGATGGGGAG 
GACCACGCCT GACAACCACT CAGCCCCCTT CCCTCCACCT CCTAG

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

ACP2 ( NM_001302491.1 ) cDNA ORF clone, Homo sapiens(human) -> NP_001289420.1 Homo sapiens acid phosphatase 2, lysosomal (ACP2), transcript variant 5, mRNA.

Price & Availability↑

CloneID	OHu56125
Clone ID Related Accession (Same CDS sequence)	NM_001302491.1
Accession Version	NM_001302491.1 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 1083bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-08-05
Organism	Homo sapiens(human)
Product	lysosomal acid phosphatase isoform 5 precursor
Comment	Comment: REVIEWED REFSEQ: This record has been curated by NCBI staff. The reference sequence was derived from DC337294.1, AK298122.1, AK300911.1 and BC093010.1. Transcript Variant: This variant (5) lacks two consecutive in-frame exons in the 5' coding region compared to variant 1. The encoded shorter isoform (5) lacks an internal protein segment compared to isoform 1. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: AK298122.1 [ECO:0000332] RNAseq introns :: mixed/partial sample support SAMEA1965299, SAMEA1966682 [ECO:0000350] ##Evidence-Data-END## COMPLETENESS: full length.

ATGGCGGGCA AGCGGTCCGG CTGGAGCCGG GCGGCTCTCC TCCAGCTCCT TCTCGGCGTG 
AACCTGGTGG TGATGCCGCC CACCCGGGCC CGGAGTCTGC GCTTCGTTAC CTTGCTGTAC 
CGCCATGGAG ACCGTTCACC AGTGAAGACA TATCCCAAGG ACCCCTATCA GGAAGAAGAA 
TGGCCCCAGG GGTTTGGTCA GTTAACCAAG GAGGGGATGC TACAGCACTG GGAACTGGGC 
CAGGCCCTGC GGCAGCGCTA TCACGGCTTC CTAAACACCT CTTATCACCG GCAAGAGGTT 
TATGTGCGAA GCACAGACTT TGACCGGACT CTCATGAGTG CTGAGGCCAA CCTGGCTGGA 
CTCTTCCCTC CCAACGGGAT GCAGCGCTTC AACCCGAACA TCTCGTGGCA GCCTATTCCT 
GTGCACACTG TGCCCATCAC TGAGGACAGG CAAACGCACG GGCTGCGCCT GCCGCCCTGG 
GCCTCACCCC AAACCATGCA GCGTCTCAGC CGGCTAAAGG ACTTCAGCTT CCGCTTCCTC 
TTCGGAATCT ACCAGCAGGC GGAGAAGGCC CGGCTTCAGG GGGGAGTCCT GCTGGCTCAG 
ATAAGGAAGA ACCTGACCCT AATGGCGACC ACCTCCCAGC TCCCCAAGCT GCTGGTTTAC 
TCTGCGCACG ACACTACCCT GGTTGCCCTG CAAATGGCAC TGGATGTCTA CAATGGTGAA 
CAAGCCCCCT ACGCCTCCTG CCACATATTT GAACTGTACC AGGAAGATTC TGGGAATTTC 
TCAGTGGAGA TGTACTTTCG GAACGAGAGT GACAAGGCCC CCTGGCCGCT CAGCCTGCCT 
GGCTGCCCTC ACCGCTGCCC ACTGCAGGAC TTCCTTCGCC TCACAGAGCC CGTCGTGCCC 
AAGGATTGGC AGCAGGAGTG CCAGCTGGCA AGCGGTCCTG CAGACACAGA GGTGATTGTG 
GCCTTGGCTG TATGTGGCTC CATCCTCTTC CTCCTCATAG TGCTGCTCCT CACCGTCCTC 
TTCCGGATGC AGGCCCAGCC TCCTGGCTAC CGCCACGTCG CAGATGGGGA GGACCACGCC 
TGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_001289420.1
CDS	59..1141
Translation	MAGKRSGWSRAALLQLLLGVNLVVMPPTRARSLRFVTLLYRHGDRSPVKTYPKDPYQEEEWPQGFGQLTKEGMLQHWELGQALRQRYHGFLNTSYHRQEVYVRSTDFDRTLMSAEANLAGLFPPNGMQRFNPNISWQPIPVHTVPITEDRQTHGLRLPPWASPQTMQRLSRLKDFSFRFLFGIYQQAEKARLQGGVLLAQIRKNLTLMATTSQLPKLLVYSAHDTTLVALQMALDVYNGEQAPYASCHIFELYQEDSGNFSVEMYFRNESDKAPWPLSLPGCPHRCPLQDFLRLTEPVVPKDWQQECQLASGPADTEVIVALAVCGSILFLLIVLLLTVLFRMQAQPPGYRHVADGEDHA

Target ORF information:

RefSeq Version	NM_001302491.1
Organism	Homo sapiens(human)
Definition	Homo sapiens acid phosphatase 2, lysosomal (ACP2), transcript variant 5, mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_001302491.1

ORF Insert Sequence:

ATGGCGGGCA AGCGGTCCGG CTGGAGCCGG GCGGCTCTCC TCCAGCTCCT TCTCGGCGTG 
AACCTGGTGG TGATGCCGCC CACCCGGGCC CGGAGTCTGC GCTTCGTTAC CTTGCTGTAC 
CGCCATGGAG ACCGTTCACC AGTGAAGACA TATCCCAAGG ACCCCTATCA GGAAGAAGAA 
TGGCCCCAGG GGTTTGGTCA GTTAACCAAG GAGGGGATGC TACAGCACTG GGAACTGGGC 
CAGGCCCTGC GGCAGCGCTA TCACGGCTTC CTAAACACCT CTTATCACCG GCAAGAGGTT 
TATGTGCGAA GCACAGACTT TGACCGGACT CTCATGAGTG CTGAGGCCAA CCTGGCTGGA 
CTCTTCCCTC CCAACGGGAT GCAGCGCTTC AACCCGAACA TCTCGTGGCA GCCTATTCCT 
GTGCACACTG TGCCCATCAC TGAGGACAGG CAAACGCACG GGCTGCGCCT GCCGCCCTGG 
GCCTCACCCC AAACCATGCA GCGTCTCAGC CGGCTAAAGG ACTTCAGCTT CCGCTTCCTC 
TTCGGAATCT ACCAGCAGGC GGAGAAGGCC CGGCTTCAGG GGGGAGTCCT GCTGGCTCAG 
ATAAGGAAGA ACCTGACCCT AATGGCGACC ACCTCCCAGC TCCCCAAGCT GCTGGTTTAC 
TCTGCGCACG ACACTACCCT GGTTGCCCTG CAAATGGCAC TGGATGTCTA CAATGGTGAA 
CAAGCCCCCT ACGCCTCCTG CCACATATTT GAACTGTACC AGGAAGATTC TGGGAATTTC 
TCAGTGGAGA TGTACTTTCG GAACGAGAGT GACAAGGCCC CCTGGCCGCT CAGCCTGCCT 
GGCTGCCCTC ACCGCTGCCC ACTGCAGGAC TTCCTTCGCC TCACAGAGCC CGTCGTGCCC 
AAGGATTGGC AGCAGGAGTG CCAGCTGGCA AGCGGTCCTG CAGACACAGA GGTGATTGTG 
GCCTTGGCTG TATGTGGCTC CATCCTCTTC CTCCTCATAG TGCTGCTCCT CACCGTCCTC 
TTCCGGATGC AGGCCCAGCC TCCTGGCTAC CGCCACGTCG CAGATGGGGA GGACCACGCC 
TGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

ACP2 ( NM_001302490.1 ) cDNA ORF clone, Homo sapiens(human) -> NP_001289419.1 Homo sapiens acid phosphatase 2, lysosomal (ACP2), transcript variant 4, mRNA.

Price & Availability↑

CloneID	OHu56126
Clone ID Related Accession (Same CDS sequence)	NM_001302490.1
Accession Version	NM_001302490.1 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 1176bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-08-04
Organism	Homo sapiens(human)
Product	lysosomal acid phosphatase isoform 4 precursor
Comment	Comment: REVIEWED REFSEQ: This record has been curated by NCBI staff. The reference sequence was derived from DC337294.1, AK301860.1, BC093010.1 and AK308512.1. Transcript Variant: This variant (4) lacks an in-frame exon in the 5' coding region compared to variant 1. The encoded shorter isoform (4) lacks an internal protein segment compared to isoform 1. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: SRR1803613.139146.1, AK301860.1 [ECO:0000332] RNAseq introns :: mixed/partial sample support SAMEA1965299, SAMEA1966682 [ECO:0000350] ##Evidence-Data-END## COMPLETENESS: full length.

ATGGCGGGCA AGCGGTCCGG CTGGAGCCGG GCGGCTCTCC TCCAGCTCCT TCTCGGCGTG 
AACCTGGTGG TGATGCCGCC CACCCGGGCC CGGAGTCTGC GCTTCGTTAC CTTGGAGGGG 
ATGCTACAGC ACTGGGAACT GGGCCAGGCC CTGCGGCAGC GCTATCACGG CTTCCTAAAC 
ACCTCTTATC ACCGGCAAGA GGTTTATGTG CGAAGCACAG ACTTTGACCG GACTCTCATG 
AGTGCTGAGG CCAACCTGGC TGGACTCTTC CCTCCCAACG GGATGCAGCG CTTCAACCCG 
AACATCTCGT GGCAGCCTAT TCCTGTGCAC ACTGTGCCCA TCACTGAGGA CAGGCTGCTG 
AAGTTCCCGT TGGGCCCATG TCCCCGTTAT GAGCAGCTGC AGAACGAGAC CCGGCAGACA 
CCAGAGTATC AGAATGAGAG TTCTCGGAAT GCACAATTTC TGGACATGGT GGCCAACGAG 
ACAGGGCTTA CAGACCTGAC ACTGGAGACC GTCTGGAATG TCTATGACAC ACTCTTCTGT 
GAGCAAACGC ACGGGCTGCG CCTGCCGCCC TGGGCCTCAC CCCAAACCAT GCAGCGTCTC 
AGCCGGCTAA AGGACTTCAG CTTCCGCTTC CTCTTCGGAA TCTACCAGCA GGCGGAGAAG 
GCCCGGCTTC AGGGGGGAGT CCTGCTGGCT CAGATAAGGA AGAACCTGAC CCTAATGGCG 
ACCACCTCCC AGCTCCCCAA GCTGCTGGTT TACTCTGCGC ACGACACTAC CCTGGTTGCC 
CTGCAAATGG CACTGGATGT CTACAATGGT GAACAAGCCC CCTACGCCTC CTGCCACATA 
TTTGAACTGT ACCAGGAAGA TTCTGGGAAT TTCTCAGTGG AGATGTACTT TCGGAACGAG 
AGTGACAAGG CCCCCTGGCC GCTCAGCCTG CCTGGCTGCC CTCACCGCTG CCCACTGCAG 
GACTTCCTTC GCCTCACAGA GCCCGTCGTG CCCAAGGATT GGCAGCAGGA GTGCCAGCTG 
GCAAGCGGTC CTGCAGACAC AGAGGTGATT GTGGCCTTGG CTGTATGTGG CTCCATCCTC 
TTCCTCCTCA TAGTGCTGCT CCTCACCGTC CTCTTCCGGA TGCAGGCCCA GCCTCCTGGC 
TACCGCCACG TCGCAGATGG GGAGGACCAC GCCTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_001289419.1
CDS	59..1234
Translation	MAGKRSGWSRAALLQLLLGVNLVVMPPTRARSLRFVTLEGMLQHWELGQALRQRYHGFLNTSYHRQEVYVRSTDFDRTLMSAEANLAGLFPPNGMQRFNPNISWQPIPVHTVPITEDRLLKFPLGPCPRYEQLQNETRQTPEYQNESSRNAQFLDMVANETGLTDLTLETVWNVYDTLFCEQTHGLRLPPWASPQTMQRLSRLKDFSFRFLFGIYQQAEKARLQGGVLLAQIRKNLTLMATTSQLPKLLVYSAHDTTLVALQMALDVYNGEQAPYASCHIFELYQEDSGNFSVEMYFRNESDKAPWPLSLPGCPHRCPLQDFLRLTEPVVPKDWQQECQLASGPADTEVIVALAVCGSILFLLIVLLLTVLFRMQAQPPGYRHVADGEDHA

Target ORF information:

RefSeq Version	NM_001302490.1
Organism	Homo sapiens(human)
Definition	Homo sapiens acid phosphatase 2, lysosomal (ACP2), transcript variant 4, mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_001302490.1

ORF Insert Sequence:

ATGGCGGGCA AGCGGTCCGG CTGGAGCCGG GCGGCTCTCC TCCAGCTCCT TCTCGGCGTG 
AACCTGGTGG TGATGCCGCC CACCCGGGCC CGGAGTCTGC GCTTCGTTAC CTTGGAGGGG 
ATGCTACAGC ACTGGGAACT GGGCCAGGCC CTGCGGCAGC GCTATCACGG CTTCCTAAAC 
ACCTCTTATC ACCGGCAAGA GGTTTATGTG CGAAGCACAG ACTTTGACCG GACTCTCATG 
AGTGCTGAGG CCAACCTGGC TGGACTCTTC CCTCCCAACG GGATGCAGCG CTTCAACCCG 
AACATCTCGT GGCAGCCTAT TCCTGTGCAC ACTGTGCCCA TCACTGAGGA CAGGCTGCTG 
AAGTTCCCGT TGGGCCCATG TCCCCGTTAT GAGCAGCTGC AGAACGAGAC CCGGCAGACA 
CCAGAGTATC AGAATGAGAG TTCTCGGAAT GCACAATTTC TGGACATGGT GGCCAACGAG 
ACAGGGCTTA CAGACCTGAC ACTGGAGACC GTCTGGAATG TCTATGACAC ACTCTTCTGT 
GAGCAAACGC ACGGGCTGCG CCTGCCGCCC TGGGCCTCAC CCCAAACCAT GCAGCGTCTC 
AGCCGGCTAA AGGACTTCAG CTTCCGCTTC CTCTTCGGAA TCTACCAGCA GGCGGAGAAG 
GCCCGGCTTC AGGGGGGAGT CCTGCTGGCT CAGATAAGGA AGAACCTGAC CCTAATGGCG 
ACCACCTCCC AGCTCCCCAA GCTGCTGGTT TACTCTGCGC ACGACACTAC CCTGGTTGCC 
CTGCAAATGG CACTGGATGT CTACAATGGT GAACAAGCCC CCTACGCCTC CTGCCACATA 
TTTGAACTGT ACCAGGAAGA TTCTGGGAAT TTCTCAGTGG AGATGTACTT TCGGAACGAG 
AGTGACAAGG CCCCCTGGCC GCTCAGCCTG CCTGGCTGCC CTCACCGCTG CCCACTGCAG 
GACTTCCTTC GCCTCACAGA GCCCGTCGTG CCCAAGGATT GGCAGCAGGA GTGCCAGCTG 
GCAAGCGGTC CTGCAGACAC AGAGGTGATT GTGGCCTTGG CTGTATGTGG CTCCATCCTC 
TTCCTCCTCA TAGTGCTGCT CCTCACCGTC CTCTTCCGGA TGCAGGCCCA GCCTCCTGGC 
TACCGCCACG TCGCAGATGG GGAGGACCAC GCCTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

ACP2 ( NM_001302489.1 ) cDNA ORF clone, Homo sapiens(human) -> NP_001289418.1 Homo sapiens acid phosphatase 2, lysosomal (ACP2), transcript variant 3, mRNA.

Price & Availability↑

CloneID	OHu56127
Clone ID Related Accession (Same CDS sequence)	NM_001302489.1
Accession Version	NM_001302489.1 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 1188bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-08-05
Organism	Homo sapiens(human)
Product	lysosomal acid phosphatase isoform 3
Comment	Comment: REVIEWED REFSEQ: This record has been curated by NCBI staff. The reference sequence was derived from AK298439.1, BC093010.1 and AK308512.1. Transcript Variant: This variant (3) contains an alternate 5' terminal exon, and initiates translation at an alternate translation start codon compared to variant 1. The encoded shorter isoform (3) has a distinct N-terminus compared to isoform 1. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: AK298439.1 [ECO:0000332] RNAseq introns :: mixed/partial sample support SAMEA1965299, SAMEA1966682 [ECO:0000350] ##Evidence-Data-END## COMPLETENESS: complete on the 3' end.

ATGGGAGTCA GGATGACCGA ATACGTCGGG CTGTACCGCC ATGGAGACCG TTCACCAGTG 
AAGACATATC CCAAGGACCC CTATCAGGAA GAAGAATGGC CCCAGGGGTT TGGTCAGTTA 
ACCAAGGAGG GGATGCTACA GCACTGGGAA CTGGGCCAGG CCCTGCGGCA GCGCTATCAC 
GGCTTCCTAA ACACCTCTTA TCACCGGCAA GAGGTTTATG TGCGAAGCAC AGACTTTGAC 
CGGACTCTCA TGAGTGCTGA GGCCAACCTG GCTGGACTCT TCCCTCCCAA CGGGATGCAG 
CGCTTCAACC CGAACATCTC GTGGCAGCCT ATTCCTGTGC ACACTGTGCC CATCACTGAG 
GACAGGCTGC TGAAGTTCCC GTTGGGCCCA TGTCCCCGTT ATGAGCAGCT GCAGAACGAG 
ACCCGGCAGA CACCAGAGTA TCAGAATGAG AGTTCTCGGA ATGCACAATT TCTGGACATG 
GTGGCCAACG AGACAGGGCT TACAGACCTG ACACTGGAGA CCGTCTGGAA TGTCTATGAC 
ACACTCTTCT GTGAGCAAAC GCACGGGCTG CGCCTGCCGC CCTGGGCCTC ACCCCAAACC 
ATGCAGCGTC TCAGCCGGCT AAAGGACTTC AGCTTCCGCT TCCTCTTCGG AATCTACCAG 
CAGGCGGAGA AGGCCCGGCT TCAGGGGGGA GTCCTGCTGG CTCAGATAAG GAAGAACCTG 
ACCCTAATGG CGACCACCTC CCAGCTCCCC AAGCTGCTGG TTTACTCTGC GCACGACACT 
ACCCTGGTTG CCCTGCAAAT GGCACTGGAT GTCTACAATG GTGAACAAGC CCCCTACGCC 
TCCTGCCACA TATTTGAACT GTACCAGGAA GATTCTGGGA ATTTCTCAGT GGAGATGTAC 
TTTCGGAACG AGAGTGACAA GGCCCCCTGG CCGCTCAGCC TGCCTGGCTG CCCTCACCGC 
TGCCCACTGC AGGACTTCCT TCGCCTCACA GAGCCCGTCG TGCCCAAGGA TTGGCAGCAG 
GAGTGCCAGC TGGCAAGCGG TCCTGCAGAC ACAGAGGTGA TTGTGGCCTT GGCTGTATGT 
GGCTCCATCC TCTTCCTCCT CATAGTGCTG CTCCTCACCG TCCTCTTCCG GATGCAGGCC 
CAGCCTCCTG GCTACCGCCA CGTCGCAGAT GGGGAGGACC ACGCCTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_001289418.1
CDS	115..1302
Translation	MGVRMTEYVGLYRHGDRSPVKTYPKDPYQEEEWPQGFGQLTKEGMLQHWELGQALRQRYHGFLNTSYHRQEVYVRSTDFDRTLMSAEANLAGLFPPNGMQRFNPNISWQPIPVHTVPITEDRLLKFPLGPCPRYEQLQNETRQTPEYQNESSRNAQFLDMVANETGLTDLTLETVWNVYDTLFCEQTHGLRLPPWASPQTMQRLSRLKDFSFRFLFGIYQQAEKARLQGGVLLAQIRKNLTLMATTSQLPKLLVYSAHDTTLVALQMALDVYNGEQAPYASCHIFELYQEDSGNFSVEMYFRNESDKAPWPLSLPGCPHRCPLQDFLRLTEPVVPKDWQQECQLASGPADTEVIVALAVCGSILFLLIVLLLTVLFRMQAQPPGYRHVADGEDHA

Target ORF information:

RefSeq Version	NM_001302489.1
Organism	Homo sapiens(human)
Definition	Homo sapiens acid phosphatase 2, lysosomal (ACP2), transcript variant 3, mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_001302489.1

ORF Insert Sequence:

ATGGGAGTCA GGATGACCGA ATACGTCGGG CTGTACCGCC ATGGAGACCG TTCACCAGTG 
AAGACATATC CCAAGGACCC CTATCAGGAA GAAGAATGGC CCCAGGGGTT TGGTCAGTTA 
ACCAAGGAGG GGATGCTACA GCACTGGGAA CTGGGCCAGG CCCTGCGGCA GCGCTATCAC 
GGCTTCCTAA ACACCTCTTA TCACCGGCAA GAGGTTTATG TGCGAAGCAC AGACTTTGAC 
CGGACTCTCA TGAGTGCTGA GGCCAACCTG GCTGGACTCT TCCCTCCCAA CGGGATGCAG 
CGCTTCAACC CGAACATCTC GTGGCAGCCT ATTCCTGTGC ACACTGTGCC CATCACTGAG 
GACAGGCTGC TGAAGTTCCC GTTGGGCCCA TGTCCCCGTT ATGAGCAGCT GCAGAACGAG 
ACCCGGCAGA CACCAGAGTA TCAGAATGAG AGTTCTCGGA ATGCACAATT TCTGGACATG 
GTGGCCAACG AGACAGGGCT TACAGACCTG ACACTGGAGA CCGTCTGGAA TGTCTATGAC 
ACACTCTTCT GTGAGCAAAC GCACGGGCTG CGCCTGCCGC CCTGGGCCTC ACCCCAAACC 
ATGCAGCGTC TCAGCCGGCT AAAGGACTTC AGCTTCCGCT TCCTCTTCGG AATCTACCAG 
CAGGCGGAGA AGGCCCGGCT TCAGGGGGGA GTCCTGCTGG CTCAGATAAG GAAGAACCTG 
ACCCTAATGG CGACCACCTC CCAGCTCCCC AAGCTGCTGG TTTACTCTGC GCACGACACT 
ACCCTGGTTG CCCTGCAAAT GGCACTGGAT GTCTACAATG GTGAACAAGC CCCCTACGCC 
TCCTGCCACA TATTTGAACT GTACCAGGAA GATTCTGGGA ATTTCTCAGT GGAGATGTAC 
TTTCGGAACG AGAGTGACAA GGCCCCCTGG CCGCTCAGCC TGCCTGGCTG CCCTCACCGC 
TGCCCACTGC AGGACTTCCT TCGCCTCACA GAGCCCGTCG TGCCCAAGGA TTGGCAGCAG 
GAGTGCCAGC TGGCAAGCGG TCCTGCAGAC ACAGAGGTGA TTGTGGCCTT GGCTGTATGT 
GGCTCCATCC TCTTCCTCCT CATAGTGCTG CTCCTCACCG TCCTCTTCCG GATGCAGGCC 
CAGCCTCCTG GCTACCGCCA CGTCGCAGAT GGGGAGGACC ACGCCTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

PubMed

Lysosomal acid phosphatase 2 is an unfavorable prognostic factor but is associated with better survival in stage II colorectal cancer patients receiving chemotherapy.
Oncotarget8(7)12120-12132(2017 Feb)
Lee YC,Su CY,Lin YF,Lin CM,Fang CY,Lin YK,Hsiao M,Chen CL

Evidence of efficient stop codon readthrough in four mammalian genes.
Nucleic acids research42(14)8928-38(2014 Aug)
Loughran G,Chou MY,Ivanov IP,Jungreis I,Kellis M,Kiran AM,Baranov PV,Atkins JF

Mutation in the gene encoding lysosomal acid phosphatase (Acp2) causes cerebellum and skin malformation in mouse.
Neurogenetics5(4)229-38(2004 Dec)
Mannan AU,Roussa E,Kraus C,Rickmann M,Maenner J,Nayernia K,Krieglstein K,Reis A,Engel W

The tyrosine motifs of Lamp 1 and LAP determine their direct and indirect targetting to lysosomes.
Journal of cell science115(Pt 1)185-94(2002 Jan)
Oberm?ller S,Kiecke C,von Figura K,H?ning S

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ACP2 cDNA ORF clone, Homo sapiens(human)

Gene

Clones

gRNAs

Related articles in PubMed

Target ORF information:

Target ORF information:

ORF Insert Sequence:

Target ORF information:

Target ORF information:

ORF Insert Sequence:

Target ORF information:

Target ORF information:

ORF Insert Sequence:

Target ORF information:

Target ORF information:

ORF Insert Sequence:

Target ORF information:

Target ORF information:

ORF Insert Sequence:

Target ORF information:

Target ORF information:

ORF Insert Sequence:

Target ORF information:

Target ORF information:

ORF Insert Sequence:

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