PIK3R2 cDNA ORF clone, Homo sapiens(human)

Gene
Clones
gRNAs

Summary

Gene Symbol	PIK3R2
Entrez Gene ID	5296
Full Name	phosphoinositide-3-kinase regulatory subunit 2
Synonyms	MPPH,MPPH1,P85B,p85,p85-BETA
General protein information	Preferred Names phosphoinositide-3-kinase regulatory subunit 2 Names phosphatidylinositol 3-kinase regulatory subunit beta PI3-kinase subunit p85-beta PI3K regulatory subunit beta phosphatidylinositol 3-kinase 85 kDa regulatory subunit beta phosphatidylinositol 3-kinase, regulatory subunit, polypeptide 2 (p85 beta) phosphoinositide-3-kinase regulatory subunit beta phosphoinositide-3-kinase, regulatory subunit 2 (beta) ptdIns-3-kinase regulatory subunit p85-beta
Gene Type	protein-coding
Organism	Homo sapiens(human)
Genome	Chromosome: 19 Map Location: 19p13.11
Summary	Phosphatidylinositol 3-kinase (PI3K) is a lipid kinase that phosphorylates phosphatidylinositol and similar compounds, creating second messengers important in growth signaling pathways. PI3K functions as a heterodimer of a regulatory and a catalytic subunit. The protein encoded by this gene is a regulatory component of PI3K. Two transcript variants, one protein coding and the other non-protein coding, have been found for this gene. [provided by RefSeq, Dec 2012].
Disorder MIM:	603157
Disorder Html:	Megalencephaly-polymicrogyria-polydactyly-hydrocephalus syndrome 1, 603387 (3)

mRNA and Protein(s)

mRNA	Protein	Name
NM_005027.4	NP_005018.2	phosphatidylinositol 3-kinase regulatory subunit beta
NM_005027.3	NP_005018.1	phosphatidylinositol 3-kinase regulatory subunit beta

Pathways from BioSystems

Homologies

Pan troglodytes (chimpanzee)	PIK3R2	XP_512509.2
Gallus gallus (chicken)	PIK3R2	XP_001233341.3
Xenopus tropicalis (tropical clawed frog)	pik3r2	XP_002934855.2
Homo sapiens (human)	PIK3R2	NP_005018.1
	PIK3R2	XP_001114094.1
Danio rerio (zebrafish)	pik3r2	NP_997987.1
Canis lupus familiaris (dog)	PIK3R2	XP_852406.2
Rattus norvegicus (Norway rat)	Pik3r2	NP_071521.2
Bos taurus (cattle)	PIK3R2	NP_777001.1
Mus musculus (house mouse)	Pik3r2	NP_032867.2

Gene Ontology
Bibliography

Related articles in PubMed

Hypoinsulinaemic, hypoketotic hypoglycaemia due to mosaic genetic activation of PI3-kinase.
Leiter SM, Parker VER, Welters A, Knox R, Rocha N, Clark G, Payne F, Lotta L, Harris J, Guerrero-Fern?ndez J, Gonz?lez-Casado I, Garc?a-Mi?aur S, Gordo G, Wareham N, Mart?nez-Glez V, Allison M, O'Rahilly S, Barroso I, Meissner T, Davies S, Hussain K, Temple K, Barreda-Bonis AC, Kummer S, Semple RK
European journal of endocrinology177(2)175-186(2017 Aug)

Architecture of the human interactome defines protein communities and disease networks.
Huttlin EL, Bruckner RJ, Paulo JA, Cannon JR, Ting L, Baltier K, Colby G, Gebreab F, Gygi MP, Parzen H, Szpyt J, Tam S, Zarraga G, Pontano-Vaites L, Swarup S, White AE, Schweppe DK, Rad R, Erickson BK, Obar RA, Guruharsha KG, Li K, Artavanis-Tsakonas S, Gygi SP, Harper JW
Nature545(7655)505-509(2017 05)

The regulation of tumor-suppressive microRNA, miR-126, in?chronic lymphocytic leukemia.
Guinn D, Lehman A, Fabian C, Yu L, Maddocks K, Andritsos LA, Jones JA, Flynn JM, Jaglowski SM, Woyach JA, Byrd JC, Johnson AJ
Cancer medicine6(4)778-787(2017 Apr)

Comparative influenza protein interactomes identify the role of plakophilin 2 in virus restriction.
Wang L, Fu B, Li W, Patil G, Liu L, Dorf ME, Li S
Nature communications813876(2017 Feb)

GeneRIFs: Gene References Into Functions What's a GeneRIF?

Mosaic mutations in PIK3CA or PIK3R2 which activate class 1A PI3K cause severe non-ketotic hypoglycaemia in a subset of patients, with the metabolic phenotype presumably related to the extent of mosaicism within the liver
Title: Hypoinsulinaemic, hypoketotic hypoglycaemia due to mosaic genetic activation of PI3-kinase.

Data indicate that miR-126 expression negatively correlates with p85beta in CLL patients and that miR-126 can effectively target p85beta in a cell-line system.
Title: The regulation of tumor-suppressive microRNA, miR-126, in?chronic lymphocytic leukemia.

PIK3R2 D557H mutation causes polymicrogyria, corpus callosum hyperplasia and focal cortical dysplasia.
Title: De novo PIK3R2 variant causes polymicrogyria, corpus callosum hyperplasia and focal cortical dysplasia.

Data show that phosphoinositol-3 kinase regulatory subunit 2 (PIK3R2) mRNA is a direct target of miR-126-3p.
Title: MicroRNA-126-3p suppresses cell proliferation by targeting PIK3R2 in Kaposi's sarcoma cells.

indicated that miR-126 expression was negatively correlated with PIK3R2 mRNA expression
Title: microRNA-126 targeting PIK3R2 promotes rheumatoid arthritis synovial fibro-blasts proliferation and resistance to apoptosis by regulating PI3K/AKT pathway.

The following PIK3R2 gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the PIK3R2 cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1⁺/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.

***CloneID	Accession No.	Definition	**Vector	*Turnaround time	Price (USD)	Select
OHu20298	NM_005027.3 Latest version!	Homo sapiens phosphoinositide-3-kinase regulatory subunit 2 (PIK3R2), transcript variant 1, mRNA.	pcDNA3.1-C-(k)DYK or customized vector	in pcDNA3.1-C-(k)DYK	$279.50-$391.30 $559.00
OHu107357	NM_005027.4 Latest version!	Homo sapiens phosphoinositide-3-kinase regulatory subunit 2 (PIK3R2), transcript variant 1, mRNA.	pcDNA3.1-C-(k)DYK or customized vector	14-16	$391.30 $559.00

ORF Online Only Promotion

Next-day Shipping ORF Clones ( in default vector with tag)
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** You may select a custom vector to replace pcDNA3.1+/C-(K)DYK after clone is added to cart.

** GenScript guarantees 100% sequence accuracy of all synthetic DNA constructs we deliver, but we do not guarantee protein expression in your experimental system. Protein expression is influenced by many factors that may vary between experiments or laboratories. In addition, please pay attention to the signal peptide, propeptide and transit peptide in target ORF, which may affect the choice of vector (N/C terminal tag vector).

***One clone ID might be correlated to multiple accession numbers, which share the same CDS sequence.

Reference Sequences (Refseq)

PIK3R2 ( NM_005027.3 ) cDNA ORF clone, Homo sapiens(human) -> NP_005018.1 Homo sapiens phosphoinositide-3-kinase regulatory subunit 2 (PIK3R2), transcript variant 1, mRNA.

Price & Availability↑

CloneID	OHu20298
Clone ID Related Accession (Same CDS sequence)	NM_005027.3
Accession Version	NM_005027.3 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 2187bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2017-12-31
Organism	Homo sapiens(human)
Product	phosphatidylinositol 3-kinase regulatory subunit beta
Comment	Comment: REVIEWED REFSEQ: This record has been curated by NCBI staff. The reference sequence was derived from HY043384.1 and BC070082.1. This sequence is a reference standard in the RefSeqGene project. On Dec 12, 2012 this sequence version replaced NM_005027.2. Transcript Variant: This variant (1) represents the protein-coding variant. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: BC070082.1, BC090249.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA1968540, SAMEA1970526 [ECO:0000348] ##Evidence-Data-END## COMPLETENESS: complete on the 3' end.

ATGGCGGGCC CTGAGGGCTT CCAGTACCGC GCTCTGTACC CGTTCCGCCG GGAGCGGCCG 
GAGGACCTGG AGCTGCTGCC CGGCGACGTG CTGGTAGTGA GCCGGGCGGC CTTGCAGGCG 
CTGGGCGTGG CCGAGGGTGG CGAGCGCTGC CCACAGAGCG TGGGCTGGAT GCCCGGCCTC 
AACGAGCGCA CACGGCAGCG AGGTGACTTC CCTGGCACCT ATGTGGAGTT CCTGGGGCCC 
GTGGCCCTGG CCCGGCCCGG CCCTCGCCCA CGGGGCCCCC GCCCACTGCC CGCCAGGCCC 
CGTGATGGGG CCCCTGAGCC AGGCCTCACA CTCCCCGACT TGCCCGAGCA GTTCTCCCCA 
CCTGATGTGG CTCCCCCTCT TCTGGTGAAG CTTGTGGAGG CCATTGAAAG GACAGGGCTG 
GACAGCGAAT CTCACTACCG CCCGGAGCTG CCCGCACCGC GTACAGACTG GTCCCTGAGC 
GACGTGGATC AGTGGGACAC GGCAGCCCTG GCTGACGGCA TTAAGAGCTT CCTGCTGGCA 
CTGCCCGCGC CGCTCGTGAC CCCCGAGGCC TCGGCCGAGG CGCGCCGGGC CCTGCGGGAG 
GCCGCGGGGC CCGTGGGGCC GGCGCTGGAG CCACCGACGC TGCCGCTGCA CCGCGCGCTC 
ACGCTGCGCT TCCTGCTCCA GCACCTGGGC CGCGTGGCCC GCCGCGCCCC GGCCCTGGGT 
CCCGCGGTCC GGGCCCTGGG CGCCACCTTT GGGCCGCTGC TGCTGCGCGC GCCGCCGCCG 
CCGTCCTCGC CGCCGCCAGG GGGCGCTCCC GACGGGAGTG AGCCCAGCCC TGACTTCCCG 
GCGCTGCTGG TGGAGAAGCT GCTTCAGGAA CACTTGGAAG AGCAGGAGGT TGCGCCCCCA 
GCGCTGCCGC CTAAACCCCC CAAGGCAAAG CCGGCCCCCA CAGTCCTGGC CAATGGAGGG 
AGCCCACCCT CCCTGCAGGA TGCTGAGTGG TACTGGGGGG ACATTTCAAG GGAGGAGGTG 
AACGAGAAAC TCCGGGACAC TCCCGATGGC ACCTTCCTAG TCCGAGATGC TTCTAGCAAG 
ATCCAGGGCG AGTACACGCT GACCCTCAGG AAAGGCGGGA ACAATAAGCT GATCAAGGTC 
TTCCACCGAG ATGGGCACTA TGGCTTCTCA GAGCCACTCA CCTTCTGCTC CGTTGTGGAC 
CTCATCAATC ACTACCGCCA CGAGTCTCTG GCCCAGTACA ATGCCAAGCT GGACACACGG 
CTCCTCTACC CTGTGTCCAA ATACCAGCAG GACCAGATTG TCAAGGAGGA CAGCGTGGAG 
GCAGTGGGCG CCCAGCTTAA GGTCTATCAC CAGCAGTACC AGGACAAGAG CCGCGAGTAT 
GACCAGCTTT ATGAAGAGTA CACACGGACC TCCCAGGAGC TGCAGATGAA GCGTACTGCA 
ATTGAGGCCT TCAATGAGAC TATCAAGATC TTTGAAGAGC AGGGCCAGAC TCAAGAGAAA 
TGCAGCAAGG AATACCTGGA GCGCTTCCGG CGTGAGGGCA ACGAGAAAGA GATGCAAAGG 
ATCCTGCTGA ACTCCGAGCG GCTCAAGTCC CGCATTGCCG AGATCCATGA GAGCCGCACG 
AAGCTGGAGC AGCAGCTGCG GGCCCAGGCC TCGGACAACA GAGAGATCGA CAAGCGCATG 
AACAGCCTCA AGCCGGACCT CATGCAGCTG CGCAAGATCC GAGACCAGTA CCTCGTGTGG 
CTCACCCAGA AAGGCGCCCG GCAGAAGAAA ATCAACGAGT GGCTGGGGAT TAAAAATGAG 
ACTGAGGACC AGTACGCACT CATGGAGGAC GAGGACGATC TCCCGCACCA CGAGGAACGC 
ACTTGGTACG TGGGCAAGAT CAACCGCACG CAGGCAGAGG AGATGCTGAG TGGCAAGCGG 
GATGGCACCT TCCTCATCCG CGAGAGCAGC CAGCGGGGCT GCTACGCCTG CTCCGTGGTA 
GTGGACGGCG ACACCAAGCA CTGCGTCATC TACCGCACGG CCACCGGCTT CGGCTTCGCG 
GAGCCCTACA ACCTGTACGG GTCGCTGAAG GAGCTGGTGC TGCACTACCA GCACGCCTCG 
CTGGTGCAGC ACAACGACGC GCTCACCGTC ACCCTGGCGC ACCCAGTGCG CGCCCCGGGC 
CCCGGCCCGC CGCCTGCCGC CCGCTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_005018.1
CDS	541..2727
Translation	MAGPEGFQYRALYPFRRERPEDLELLPGDVLVVSRAALQALGVAEGGERCPQSVGWMPGLNERTRQRGDFPGTYVEFLGPVALARPGPRPRGPRPLPARPRDGAPEPGLTLPDLPEQFSPPDVAPPLLVKLVEAIERTGLDSESHYRPELPAPRTDWSLSDVDQWDTAALADGIKSFLLALPAPLVTPEASAEARRALREAAGPVGPALEPPTLPLHRALTLRFLLQHLGRVARRAPALGPAVRALGATFGPLLLRAPPPPSSPPPGGAPDGSEPSPDFPALLVEKLLQEHLEEQEVAPPALPPKPPKAKPAPTVLANGGSPPSLQDAEWYWGDISREEVNEKLRDTPDGTFLVRDASSKIQGEYTLTLRKGGNNKLIKVFHRDGHYGFSEPLTFCSVVDLINHYRHESLAQYNAKLDTRLLYPVSKYQQDQIVKEDSVEAVGAQLKVYHQQYQDKSREYDQLYEEYTRTSQELQMKRTAIEAFNETIKIFEEQGQTQEKCSKEYLERFRREGNEKEMQRILLNSERLKSRIAEIHESRTKLEQQLRAQASDNREIDKRMNSLKPDLMQLRKIRDQYLVWLTQKGARQKKINEWLGIKNETEDQYALMEDEDDLPHHEERTWYVGKINRTQAEEMLSGKRDGTFLIRESSQRGCYACSVVVDGDTKHCVIYRTATGFGFAEPYNLYGSLKELVLHYQHASLVQHNDALTVTLAHPVRAPGPGPPPAAR

Target ORF information:

RefSeq Version	NM_005027.3
Organism	Homo sapiens(human)
Definition	Homo sapiens phosphoinositide-3-kinase regulatory subunit 2 (PIK3R2), transcript variant 1, mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_005027.3

ORF Insert Sequence:

ATGGCGGGCC CTGAGGGCTT CCAGTACCGC GCTCTGTACC CGTTCCGCCG GGAGCGGCCG 
GAGGACCTGG AGCTGCTGCC CGGCGACGTG CTGGTAGTGA GCCGGGCGGC CTTGCAGGCG 
CTGGGCGTGG CCGAGGGTGG CGAGCGCTGC CCACAGAGCG TGGGCTGGAT GCCCGGCCTC 
AACGAGCGCA CACGGCAGCG AGGTGACTTC CCTGGCACCT ATGTGGAGTT CCTGGGGCCC 
GTGGCCCTGG CCCGGCCCGG CCCTCGCCCA CGGGGCCCCC GCCCACTGCC CGCCAGGCCC 
CGTGATGGGG CCCCTGAGCC AGGCCTCACA CTCCCCGACT TGCCCGAGCA GTTCTCCCCA 
CCTGATGTGG CTCCCCCTCT TCTGGTGAAG CTTGTGGAGG CCATTGAAAG GACAGGGCTG 
GACAGCGAAT CTCACTACCG CCCGGAGCTG CCCGCACCGC GTACAGACTG GTCCCTGAGC 
GACGTGGATC AGTGGGACAC GGCAGCCCTG GCTGACGGCA TTAAGAGCTT CCTGCTGGCA 
CTGCCCGCGC CGCTCGTGAC CCCCGAGGCC TCGGCCGAGG CGCGCCGGGC CCTGCGGGAG 
GCCGCGGGGC CCGTGGGGCC GGCGCTGGAG CCACCGACGC TGCCGCTGCA CCGCGCGCTC 
ACGCTGCGCT TCCTGCTCCA GCACCTGGGC CGCGTGGCCC GCCGCGCCCC GGCCCTGGGT 
CCCGCGGTCC GGGCCCTGGG CGCCACCTTT GGGCCGCTGC TGCTGCGCGC GCCGCCGCCG 
CCGTCCTCGC CGCCGCCAGG GGGCGCTCCC GACGGGAGTG AGCCCAGCCC TGACTTCCCG 
GCGCTGCTGG TGGAGAAGCT GCTTCAGGAA CACTTGGAAG AGCAGGAGGT TGCGCCCCCA 
GCGCTGCCGC CTAAACCCCC CAAGGCAAAG CCGGCCCCCA CAGTCCTGGC CAATGGAGGG 
AGCCCACCCT CCCTGCAGGA TGCTGAGTGG TACTGGGGGG ACATTTCAAG GGAGGAGGTG 
AACGAGAAAC TCCGGGACAC TCCCGATGGC ACCTTCCTAG TCCGAGATGC TTCTAGCAAG 
ATCCAGGGCG AGTACACGCT GACCCTCAGG AAAGGCGGGA ACAATAAGCT GATCAAGGTC 
TTCCACCGAG ATGGGCACTA TGGCTTCTCA GAGCCACTCA CCTTCTGCTC CGTTGTGGAC 
CTCATCAATC ACTACCGCCA CGAGTCTCTG GCCCAGTACA ATGCCAAGCT GGACACACGG 
CTCCTCTACC CTGTGTCCAA ATACCAGCAG GACCAGATTG TCAAGGAGGA CAGCGTGGAG 
GCAGTGGGCG CCCAGCTTAA GGTCTATCAC CAGCAGTACC AGGACAAGAG CCGCGAGTAT 
GACCAGCTTT ATGAAGAGTA CACACGGACC TCCCAGGAGC TGCAGATGAA GCGTACTGCA 
ATTGAGGCCT TCAATGAGAC TATCAAGATC TTTGAAGAGC AGGGCCAGAC TCAAGAGAAA 
TGCAGCAAGG AATACCTGGA GCGCTTCCGG CGTGAGGGCA ACGAGAAAGA GATGCAAAGG 
ATCCTGCTGA ACTCCGAGCG GCTCAAGTCC CGCATTGCCG AGATCCATGA GAGCCGCACG 
AAGCTGGAGC AGCAGCTGCG GGCCCAGGCC TCGGACAACA GAGAGATCGA CAAGCGCATG 
AACAGCCTCA AGCCGGACCT CATGCAGCTG CGCAAGATCC GAGACCAGTA CCTCGTGTGG 
CTCACCCAGA AAGGCGCCCG GCAGAAGAAA ATCAACGAGT GGCTGGGGAT TAAAAATGAG 
ACTGAGGACC AGTACGCACT CATGGAGGAC GAGGACGATC TCCCGCACCA CGAGGAACGC 
ACTTGGTACG TGGGCAAGAT CAACCGCACG CAGGCAGAGG AGATGCTGAG TGGCAAGCGG 
GATGGCACCT TCCTCATCCG CGAGAGCAGC CAGCGGGGCT GCTACGCCTG CTCCGTGGTA 
GTGGACGGCG ACACCAAGCA CTGCGTCATC TACCGCACGG CCACCGGCTT CGGCTTCGCG 
GAGCCCTACA ACCTGTACGG GTCGCTGAAG GAGCTGGTGC TGCACTACCA GCACGCCTCG 
CTGGTGCAGC ACAACGACGC GCTCACCGTC ACCCTGGCGC ACCCAGTGCG CGCCCCGGGC 
CCCGGCCCGC CGCCTGCCGC CCGCTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

PIK3R2 ( NM_005027.4 ) cDNA ORF clone, Homo sapiens(human) -> NP_005018.2 Homo sapiens phosphoinositide-3-kinase regulatory subunit 2 (PIK3R2), transcript variant 1, mRNA.

Price & Availability↑

CloneID	OHu107357
Clone ID Related Accession (Same CDS sequence)	NM_005027.4
Accession Version	NM_005027.4 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 2187bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-10-09
Organism	Homo sapiens(human)
Product	phosphatidylinositol 3-kinase regulatory subunit beta
Comment	Comment: REVIEWED REFSEQ: This record has been curated by NCBI staff. The reference sequence was derived from AC007192.1. This sequence is a reference standard in the RefSeqGene project. On Nov 23, 2018 this sequence version replaced NM_005027.3. Transcript Variant: This variant (1) represents the protein-coding variant. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: BC090249.1, BC070082.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA1968540, SAMEA1970526 [ECO:0000348] ##Evidence-Data-END## ##RefSeq-Attributes-START## MANE Ensembl match :: ENST00000222254.13/ ENSP00000222254.6 RefSeq Select criteria :: based on single protein-coding transcript ##RefSeq-Attributes-END## COMPLETENESS: full length.

ATGGCGGGCC CTGAGGGCTT CCAGTACCGC GCTCTGTACC CGTTCCGCCG GGAGCGGCCG 
GAGGACCTGG AGCTGCTGCC CGGCGACGTG CTGGTAGTGA GCCGGGCGGC CTTGCAGGCG 
CTGGGCGTGG CCGAGGGTGG CGAGCGCTGC CCACAGAGCG TGGGCTGGAT GCCCGGCCTC 
AACGAGCGCA CACGGCAGCG AGGTGACTTC CCTGGCACCT ATGTGGAGTT CCTGGGGCCC 
GTGGCCCTGG CCCGGCCCGG CCCTCGCCCA CGGGGCCCCC GCCCACTGCC CGCCAGGCCC 
CGTGATGGGG CCCCTGAGCC AGGCCTCACA CTCCCCGACT TGCCCGAGCA GTTCTCCCCA 
CCTGATGTGG CTCCCCCTCT TCTGGTGAAG CTTGTGGAGG CCATTGAAAG GACAGGGCTG 
GACAGCGAAT CTCACTACCG CCCGGAGCTG CCCGCACCGC GTACAGACTG GTCCCTGAGC 
GACGTGGATC AGTGGGACAC GGCAGCCCTG GCTGACGGCA TTAAGAGCTT CCTGCTGGCA 
CTGCCCGCGC CGCTCGTGAC CCCCGAGGCC TCGGCCGAGG CGCGCCGGGC CCTGCGGGAG 
GCCGCGGGGC CCGTGGGGCC GGCGCTGGAG CCACCGACGC TGCCGCTGCA CCGCGCGCTC 
ACGCTGCGCT TCCTGCTCCA GCACCTGGGC CGCGTGGCCA GCCGCGCCCC GGCCCTGGGT 
CCCGCGGTCC GGGCCCTGGG CGCCACCTTT GGGCCGCTGC TGCTGCGCGC GCCGCCGCCG 
CCGTCCTCGC CGCCGCCAGG GGGCGCTCCC GACGGGAGTG AGCCCAGCCC TGACTTCCCG 
GCGCTGCTGG TGGAGAAGCT GCTTCAGGAA CACTTGGAAG AGCAGGAGGT TGCGCCCCCA 
GCGCTGCCGC CTAAACCCCC CAAGGCAAAG CCGGCCTCCA CAGTCCTGGC CAATGGAGGG 
AGCCCACCCT CCCTGCAGGA TGCTGAGTGG TACTGGGGGG ACATTTCAAG GGAGGAGGTG 
AACGAGAAAC TCCGGGACAC TCCCGATGGC ACCTTCCTAG TCCGAGATGC TTCTAGCAAG 
ATCCAGGGCG AGTACACGCT GACCCTCAGG AAAGGCGGGA ACAATAAGCT GATCAAGGTC 
TTCCACCGAG ATGGGCACTA TGGCTTCTCA GAGCCACTCA CCTTCTGCTC CGTTGTGGAC 
CTCATCAATC ACTACCGCCA CGAGTCTCTG GCCCAGTACA ATGCCAAGCT GGACACACGG 
CTCCTCTACC CTGTGTCCAA ATACCAGCAG GACCAGATTG TCAAGGAGGA CAGCGTGGAG 
GCAGTGGGCG CCCAGCTTAA GGTCTATCAC CAGCAGTACC AGGACAAGAG CCGCGAGTAT 
GACCAGCTTT ATGAAGAGTA CACACGGACC TCCCAGGAGC TGCAGATGAA GCGTACTGCA 
ATTGAGGCCT TCAATGAGAC TATCAAGATC TTTGAAGAGC AGGGCCAGAC TCAAGAGAAA 
TGCAGCAAGG AATACCTGGA GCGCTTCCGG CGTGAGGGCA ACGAGAAAGA GATGCAAAGG 
ATCCTGCTGA ACTCCGAGCG GCTCAAGTCC CGCATTGCCG AGATCCATGA GAGCCGCACG 
AAGCTGGAGC AGCAGCTGCG GGCCCAGGCC TCGGACAACA GAGAGATCGA CAAGCGCATG 
AACAGCCTCA AGCCGGACCT CATGCAGCTG CGCAAGATCC GAGACCAGTA CCTCGTGTGG 
CTCACCCAGA AAGGCGCCCG GCAGAAGAAA ATCAACGAGT GGCTGGGGAT TAAAAATGAG 
ACTGAGGACC AGTACGCACT CATGGAGGAC GAGGACGATC TCCCGCACCA CGAGGAACGC 
ACTTGGTACG TGGGCAAGAT CAACCGCACG CAGGCAGAGG AGATGCTGAG TGGCAAGCGG 
GATGGCACCT TCCTCATCCG CGAGAGCAGC CAGCGGGGCT GCTACGCCTG CTCCGTGGTA 
GTGGACGGCG ACACCAAGCA CTGCGTCATC TACCGCACGG CCACCGGCTT CGGCTTCGCG 
GAGCCCTACA ACCTGTACGG GTCGCTGAAG GAGCTGGTGC TGCACTACCA GCACGCCTCG 
CTGGTGCAGC ACAACGACGC GCTCACCGTC ACCCTGGCGC ACCCAGTGCG CGCCCCGGGC 
CCCGGCCCGC CGCCTGCCGC CCGCTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_005018.2
CDS	556..2742
Translation	MAGPEGFQYRALYPFRRERPEDLELLPGDVLVVSRAALQALGVAEGGERCPQSVGWMPGLNERTRQRGDFPGTYVEFLGPVALARPGPRPRGPRPLPARPRDGAPEPGLTLPDLPEQFSPPDVAPPLLVKLVEAIERTGLDSESHYRPELPAPRTDWSLSDVDQWDTAALADGIKSFLLALPAPLVTPEASAEARRALREAAGPVGPALEPPTLPLHRALTLRFLLQHLGRVASRAPALGPAVRALGATFGPLLLRAPPPPSSPPPGGAPDGSEPSPDFPALLVEKLLQEHLEEQEVAPPALPPKPPKAKPASTVLANGGSPPSLQDAEWYWGDISREEVNEKLRDTPDGTFLVRDASSKIQGEYTLTLRKGGNNKLIKVFHRDGHYGFSEPLTFCSVVDLINHYRHESLAQYNAKLDTRLLYPVSKYQQDQIVKEDSVEAVGAQLKVYHQQYQDKSREYDQLYEEYTRTSQELQMKRTAIEAFNETIKIFEEQGQTQEKCSKEYLERFRREGNEKEMQRILLNSERLKSRIAEIHESRTKLEQQLRAQASDNREIDKRMNSLKPDLMQLRKIRDQYLVWLTQKGARQKKINEWLGIKNETEDQYALMEDEDDLPHHEERTWYVGKINRTQAEEMLSGKRDGTFLIRESSQRGCYACSVVVDGDTKHCVIYRTATGFGFAEPYNLYGSLKELVLHYQHASLVQHNDALTVTLAHPVRAPGPGPPPAAR

Target ORF information:

RefSeq Version	NM_005027.4
Organism	Homo sapiens(human)
Definition	Homo sapiens phosphoinositide-3-kinase regulatory subunit 2 (PIK3R2), transcript variant 1, mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_005027.4

ORF Insert Sequence:

ATGGCGGGCC CTGAGGGCTT CCAGTACCGC GCTCTGTACC CGTTCCGCCG GGAGCGGCCG 
GAGGACCTGG AGCTGCTGCC CGGCGACGTG CTGGTAGTGA GCCGGGCGGC CTTGCAGGCG 
CTGGGCGTGG CCGAGGGTGG CGAGCGCTGC CCACAGAGCG TGGGCTGGAT GCCCGGCCTC 
AACGAGCGCA CACGGCAGCG AGGTGACTTC CCTGGCACCT ATGTGGAGTT CCTGGGGCCC 
GTGGCCCTGG CCCGGCCCGG CCCTCGCCCA CGGGGCCCCC GCCCACTGCC CGCCAGGCCC 
CGTGATGGGG CCCCTGAGCC AGGCCTCACA CTCCCCGACT TGCCCGAGCA GTTCTCCCCA 
CCTGATGTGG CTCCCCCTCT TCTGGTGAAG CTTGTGGAGG CCATTGAAAG GACAGGGCTG 
GACAGCGAAT CTCACTACCG CCCGGAGCTG CCCGCACCGC GTACAGACTG GTCCCTGAGC 
GACGTGGATC AGTGGGACAC GGCAGCCCTG GCTGACGGCA TTAAGAGCTT CCTGCTGGCA 
CTGCCCGCGC CGCTCGTGAC CCCCGAGGCC TCGGCCGAGG CGCGCCGGGC CCTGCGGGAG 
GCCGCGGGGC CCGTGGGGCC GGCGCTGGAG CCACCGACGC TGCCGCTGCA CCGCGCGCTC 
ACGCTGCGCT TCCTGCTCCA GCACCTGGGC CGCGTGGCCA GCCGCGCCCC GGCCCTGGGT 
CCCGCGGTCC GGGCCCTGGG CGCCACCTTT GGGCCGCTGC TGCTGCGCGC GCCGCCGCCG 
CCGTCCTCGC CGCCGCCAGG GGGCGCTCCC GACGGGAGTG AGCCCAGCCC TGACTTCCCG 
GCGCTGCTGG TGGAGAAGCT GCTTCAGGAA CACTTGGAAG AGCAGGAGGT TGCGCCCCCA 
GCGCTGCCGC CTAAACCCCC CAAGGCAAAG CCGGCCTCCA CAGTCCTGGC CAATGGAGGG 
AGCCCACCCT CCCTGCAGGA TGCTGAGTGG TACTGGGGGG ACATTTCAAG GGAGGAGGTG 
AACGAGAAAC TCCGGGACAC TCCCGATGGC ACCTTCCTAG TCCGAGATGC TTCTAGCAAG 
ATCCAGGGCG AGTACACGCT GACCCTCAGG AAAGGCGGGA ACAATAAGCT GATCAAGGTC 
TTCCACCGAG ATGGGCACTA TGGCTTCTCA GAGCCACTCA CCTTCTGCTC CGTTGTGGAC 
CTCATCAATC ACTACCGCCA CGAGTCTCTG GCCCAGTACA ATGCCAAGCT GGACACACGG 
CTCCTCTACC CTGTGTCCAA ATACCAGCAG GACCAGATTG TCAAGGAGGA CAGCGTGGAG 
GCAGTGGGCG CCCAGCTTAA GGTCTATCAC CAGCAGTACC AGGACAAGAG CCGCGAGTAT 
GACCAGCTTT ATGAAGAGTA CACACGGACC TCCCAGGAGC TGCAGATGAA GCGTACTGCA 
ATTGAGGCCT TCAATGAGAC TATCAAGATC TTTGAAGAGC AGGGCCAGAC TCAAGAGAAA 
TGCAGCAAGG AATACCTGGA GCGCTTCCGG CGTGAGGGCA ACGAGAAAGA GATGCAAAGG 
ATCCTGCTGA ACTCCGAGCG GCTCAAGTCC CGCATTGCCG AGATCCATGA GAGCCGCACG 
AAGCTGGAGC AGCAGCTGCG GGCCCAGGCC TCGGACAACA GAGAGATCGA CAAGCGCATG 
AACAGCCTCA AGCCGGACCT CATGCAGCTG CGCAAGATCC GAGACCAGTA CCTCGTGTGG 
CTCACCCAGA AAGGCGCCCG GCAGAAGAAA ATCAACGAGT GGCTGGGGAT TAAAAATGAG 
ACTGAGGACC AGTACGCACT CATGGAGGAC GAGGACGATC TCCCGCACCA CGAGGAACGC 
ACTTGGTACG TGGGCAAGAT CAACCGCACG CAGGCAGAGG AGATGCTGAG TGGCAAGCGG 
GATGGCACCT TCCTCATCCG CGAGAGCAGC CAGCGGGGCT GCTACGCCTG CTCCGTGGTA 
GTGGACGGCG ACACCAAGCA CTGCGTCATC TACCGCACGG CCACCGGCTT CGGCTTCGCG 
GAGCCCTACA ACCTGTACGG GTCGCTGAAG GAGCTGGTGC TGCACTACCA GCACGCCTCG 
CTGGTGCAGC ACAACGACGC GCTCACCGTC ACCCTGGCGC ACCCAGTGCG CGCCCCGGGC 
CCCGGCCCGC CGCCTGCCGC CCGCTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

PubMed

Hypoinsulinaemic, hypoketotic hypoglycaemia due to mosaic genetic activation of PI3-kinase.
European journal of endocrinology177(2)175-186(2017 Aug)
Leiter SM,Parker VER,Welters A,Knox R,Rocha N,Clark G,Payne F,Lotta L,Harris J,Guerrero-Fern?ndez J,Gonz?lez-Casado I,Garc?a-Mi?aur S,Gordo G,Wareham N,Mart?nez-Glez V,Allison M,O'Rahilly S,Barroso I,Meissner T,Davies S,Hussain K,Temple K,Barreda-Bonis AC,Kummer S,Semple RK

Architecture of the human interactome defines protein communities and disease networks.
Nature545(7655)505-509(2017 05)
Huttlin EL,Bruckner RJ,Paulo JA,Cannon JR,Ting L,Baltier K,Colby G,Gebreab F,Gygi MP,Parzen H,Szpyt J,Tam S,Zarraga G,Pontano-Vaites L,Swarup S,White AE,Schweppe DK,Rad R,Erickson BK,Obar RA,Guruharsha KG,Li K,Artavanis-Tsakonas S,Gygi SP,Harper JW

The regulation of tumor-suppressive microRNA, miR-126, in?chronic lymphocytic leukemia.
Cancer medicine6(4)778-787(2017 Apr)
Guinn D,Lehman A,Fabian C,Yu L,Maddocks K,Andritsos LA,Jones JA,Flynn JM,Jaglowski SM,Woyach JA,Byrd JC,Johnson AJ

Comparative influenza protein interactomes identify the role of plakophilin 2 in virus restriction.
Nature communications813876(2017 Feb)
Wang L,Fu B,Li W,Patil G,Liu L,Dorf ME,Li S

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PIK3R2 cDNA ORF clone, Homo sapiens(human)

Gene

Clones

gRNAs

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Target ORF information:

Target ORF information:

ORF Insert Sequence:

Target ORF information:

Target ORF information:

ORF Insert Sequence:

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