GINS2 cDNA ORF clone, Homo sapiens(human)

Gene
Clones
gRNAs

Summary

Gene Symbol	GINS2
Entrez Gene ID	51659
Full Name	GINS complex subunit 2
Synonyms	HSPC037,PSF2,Pfs2
General protein information	Preferred Names GINS complex subunit 2 Names DNA replication complex GINS protein PSF2 GINS complex subunit 2 (Psf2 homolog)
Gene Type	protein-coding
Organism	Homo sapiens(human)
Genome	Chromosome: 16 Map Location: 16q24.1
Summary	The yeast heterotetrameric GINS complex is made up of Sld5 (GINS4; MIM 610611), Psf1 (GINS1; MIM 610608), Psf2, and Psf3 (GINS3; MIM 610610). The formation of this complex is essential for the initiation of DNA replication in yeast and Xenopus egg extracts (Ueno et al., 2005 [PubMed 16287864]). See GINS1 for additional information about the GINS complex.[supplied by OMIM, Mar 2008].
Disorder MIM:	610609

mRNA and Protein(s)

mRNA	Protein	Name
NM_016095.3	NP_057179.1	DNA replication complex GINS protein PSF2
NM_016095.2	NP_057179.1	DNA replication complex GINS protein PSF2

Pathways from BioSystems

Homologies

Bos taurus (cattle)	GINS2	XP_002694797.1
Schizosaccharomyces pombe (fission yeast)	psf2	NP_595493.1
Neurospora crassa	NCU06322	XP_962584.1
Pan troglodytes (chimpanzee)	GINS2	XP_511151.2
Gallus gallus (chicken)	GINS2	XP_414187.3
Drosophila melanogaster (fruit fly)	Psf2	NP_608826.4
Anopheles gambiae (African malaria mosquito)	AgaP_AGAP010018	XP_553913.3
Caenorhabditis elegans (roundworm)	F31C3.5	NP_493627.1
Saccharomyces cerevisiae (baker's yeast)	PSF2	NP_012463.1
Oryza sativa (rice)	Os01g0248600	NP_001042585.1
Xenopus tropicalis (tropical clawed frog)	gins2	NP_001017015.1
Homo sapiens (human)	GINS2	NP_057179.1
Danio rerio (zebrafish)	gins2	NP_001019610.1
Kluyveromyces lactis	KLLA0D06501g	XP_453351.1
Eremothecium gossypii	AGOS_ADR121W	NP_984217.1
Rattus norvegicus (Norway rat)	Gins2	NP_001099660.1
Anopheles gambiae (African malaria mosquito)	AgaP_AGAP012743	XP_560987.4
Magnaporthe oryzae (rice blast fungus)	MGG_01917	XP_003719344.1
	GINS2	XP_001082775.1
Canis lupus familiaris (dog)	GINS2	XP_851786.1
Mus musculus (house mouse)	Gins2	NP_849187.1
Arabidopsis thaliana (thale cress)	PSF2	NP_187859.2

Gene Ontology
Bibliography

Related articles in PubMed

GINS2 is a novel prognostic biomarker and promotes tumor progression in early-stage cervical cancer.
Ouyang F, Liu J, Xia M, Lin C, Wu X, Ye L, Song L, Li J, Wang J, Guo P, He M
Oncology reports37(5)2652-2662(2017 May)

New insights into the GINS complex explain the controversy between existing structural models.
Carroni M, De March M, Medagli B, Krastanova I, Taylor IA, Amenitsch H, Araki H, Pisani FM, Patwardhan A, Onesti S
Scientific reports740188(2017 Jan)

GINS2 regulates matrix metallopeptidase 9 expression and cancer stem cell property in human triple negative Breast cancer.
Peng L, Song Z, Chen D, Linghu R, Wang Y, Zhang X, Kou X, Yang J, Jiao S
Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie841568-1574(2016 Dec)

GeneRIFs: Gene References Into Functions What's a GeneRIF?

GINS2 is overexpressed in cervical cancer.GINS2 is a novel indicator of pelvic lymph node metastasis in cervical cancer.
Title: GINS2 is a novel prognostic biomarker and promotes tumor progression in early-stage cervical cancer.

silencing of GINS2 in triple negative breast cancer cells caused dramatic decrease of matrix metalloproteinase-9 (MMP9).
Title: GINS2 regulates matrix metallopeptidase 9 expression and cancer stem cell property in human triple negative Breast cancer.

High GINS2 transcript level is associated with endocrine therapy resistance in beast cancer.
Title: High GINS2 transcript level predicts poor prognosis and correlates with high histological grade and endocrine therapy resistance through mammary cancer stem cells in breast cancer patients.

GINS2 plays an important role in apoptosis and may function via the p38MAPK signaling pathway.
Title: Roles of GINS2 in K562 human chronic myelogenous leukemia and NB4 acute promyelocytic leukemia cells.

On the contrary, after HL60 cells were infected by recombinant adenovirus vector which contained GINS2 gene, we observed that over-expression of GINS2 could promote HL-60 cell proliferation.
Title: Effect of GINS2 on proliferation and apoptosis in leukemic cell line.

The following GINS2 gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the GINS2 cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1⁺/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.

***CloneID	Accession No.	Definition	**Vector	*Turnaround time	Price (USD)
OHu27079	NM_016095.3 Latest version!	Homo sapiens GINS complex subunit 2 (GINS2), mRNA.	pcDNA3.1-C-(k)DYK or customized vector	in pcDNA3.1-C-(k)DYK	$49.50-$69.30 $99.00
View Old Accession Versions >>
OHu27079	NM_016095.2	Homo sapiens GINS complex subunit 2 (GINS2), mRNA.	pcDNA3.1-C-(k)DYK or customized vector	in pcDNA3.1-C-(k)DYK	$49.50-$69.30 $99.00
Hide Old Accession Versions >>

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** GenScript guarantees 100% sequence accuracy of all synthetic DNA constructs we deliver, but we do not guarantee protein expression in your experimental system. Protein expression is influenced by many factors that may vary between experiments or laboratories. In addition, please pay attention to the signal peptide, propeptide and transit peptide in target ORF, which may affect the choice of vector (N/C terminal tag vector).

***One clone ID might be correlated to multiple accession numbers, which share the same CDS sequence.

Reference Sequences (Refseq)

GINS2 ( NM_016095.3 ) cDNA ORF clone, Homo sapiens(human) -> NP_057179.1 Homo sapiens GINS complex subunit 2 (GINS2), mRNA.

Price & Availability↑

CloneID	OHu27079
Clone ID Related Accession (Same CDS sequence)	NM_016095.3 , NM_016095.2
Accession Version	NM_016095.3 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 558bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-08-06
Organism	Homo sapiens(human)
Product	DNA replication complex GINS protein PSF2
Comment	Comment: VALIDATED REFSEQ: This record has undergone validation or preliminary review. The reference sequence was derived from BC010164.2, AF201939.1 and AC123908.3. On Nov 23, 2018 this sequence version replaced NM_016095.2. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: SRR3476690.164475.1, SRR3476690.52716.1 [ECO:0000332] RNAseq introns :: mixed/partial sample support SAMEA1965299, SAMEA1966682 [ECO:0000350] ##Evidence-Data-END## ##RefSeq-Attributes-START## MANE Ensembl match :: ENST00000253462.8/ ENSP00000253462.3 RefSeq Select criteria :: based on single protein-coding transcript ##RefSeq-Attributes-END## COMPLETENESS: full length.

ATGGACGCTG CCGAGGTCGA ATTCCTCGCC GAGAAGGAGC TGGTTACCAT TATCCCCAAC 
TTCAGTCTGG ACAAGATCTA CCTCATCGGG GGGGACCTGG GGCCTTTTAA CCCTGGTTTA 
CCCGTGGAAG TGCCCCTGTG GCTGGCGATT AACCTGAAAC AAAGACAGAA ATGTCGCCTG 
CTCCCTCCAG AGTGGATGGA TGTAGAAAAG TTGGAGAAGA TGAGGGATCA TGAACGAAAG 
GAAGAAACTT TTACCCCAAT GCCCAGCCCT TACTACATGG AACTTACGAA GCTCCTGTTA 
AATCATGCTT CAGACAACAT CCCGAAGGCA GACGAAATCC GGACCCTGGT CAAGGATATG 
TGGGACACTC GTATAGCCAA ACTCCGAGTG TCTGCTGACA GCTTTGTGAG ACAGCAGGAG 
GCACATGCCA AGCTGGATAA CTTGACCTTG ATGGAGATCA ACACCAGCGG GACTTTCCTC 
ACACAAGCGC TCAACCACAT GTACAAACTC CGCACGAACC TCCAGCCTCT GGAGAGTACT 
CAGTCTCAGG ACTTCTAG

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_057179.1
CDS	57..614
Translation	MDAAEVEFLAEKELVTIIPNFSLDKIYLIGGDLGPFNPGLPVEVPLWLAINLKQRQKCRLLPPEWMDVEKLEKMRDHERKEETFTPMPSPYYMELTKLLLNHASDNIPKADEIRTLVKDMWDTRIAKLRVSADSFVRQQEAHAKLDNLTLMEINTSGTFLTQALNHMYKLRTNLQPLESTQSQDF

Target ORF information:

RefSeq Version	NM_016095.3
Organism	Homo sapiens(human)
Definition	Homo sapiens GINS complex subunit 2 (GINS2), mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_016095.3

ORF Insert Sequence:

ATGGACGCTG CCGAGGTCGA ATTCCTCGCC GAGAAGGAGC TGGTTACCAT TATCCCCAAC 
TTCAGTCTGG ACAAGATCTA CCTCATCGGG GGGGACCTGG GGCCTTTTAA CCCTGGTTTA 
CCCGTGGAAG TGCCCCTGTG GCTGGCGATT AACCTGAAAC AAAGACAGAA ATGTCGCCTG 
CTCCCTCCAG AGTGGATGGA TGTAGAAAAG TTGGAGAAGA TGAGGGATCA TGAACGAAAG 
GAAGAAACTT TTACCCCAAT GCCCAGCCCT TACTACATGG AACTTACGAA GCTCCTGTTA 
AATCATGCTT CAGACAACAT CCCGAAGGCA GACGAAATCC GGACCCTGGT CAAGGATATG 
TGGGACACTC GTATAGCCAA ACTCCGAGTG TCTGCTGACA GCTTTGTGAG ACAGCAGGAG 
GCACATGCCA AGCTGGATAA CTTGACCTTG ATGGAGATCA ACACCAGCGG GACTTTCCTC 
ACACAAGCGC TCAACCACAT GTACAAACTC CGCACGAACC TCCAGCCTCT GGAGAGTACT 
CAGTCTCAGG ACTTCTAG

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

GINS2 ( NM_016095.2 ) cDNA ORF clone, Homo sapiens(human) -> NP_057179.1 Homo sapiens GINS complex subunit 2 (GINS2), mRNA.

Price & Availability↑

CloneID	OHu27079
Clone ID Related Accession (Same CDS sequence)	NM_016095.3 , NM_016095.2
Accession Version	NM_016095.2	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 558bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2017-10-01
Organism	Homo sapiens(human)
Product	DNA replication complex GINS protein PSF2
Comment	Comment: VALIDATED REFSEQ: This record has undergone validation or preliminary review. The reference sequence was derived from BE514978.1, AF201939.1 and BC010164.2. On Nov 14, 2008 this sequence version replaced NM_016095.1. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: BC003186.1, SRR1163658.162615.1 [ECO:0000332] RNAseq introns :: mixed/partial sample support SAMEA1965299, SAMEA1966682 [ECO:0000350] ##Evidence-Data-END##

ATGGACGCTG CCGAGGTCGA ATTCCTCGCC GAGAAGGAGC TGGTTACCAT TATCCCCAAC 
TTCAGTCTGG ACAAGATCTA CCTCATCGGG GGGGACCTGG GGCCTTTTAA CCCTGGTTTA 
CCCGTGGAAG TGCCCCTGTG GCTGGCGATT AACCTGAAAC AAAGACAGAA ATGTCGCCTG 
CTCCCTCCAG AGTGGATGGA TGTAGAAAAG TTGGAGAAGA TGAGGGATCA TGAACGAAAG 
GAAGAAACTT TTACCCCAAT GCCCAGCCCT TACTACATGG AACTTACGAA GCTCCTGTTA 
AATCATGCTT CAGACAACAT CCCGAAGGCA GACGAAATCC GGACCCTGGT CAAGGATATG 
TGGGACACTC GTATAGCCAA ACTCCGAGTG TCTGCTGACA GCTTTGTGAG ACAGCAGGAG 
GCACATGCCA AGCTGGATAA CTTGACCTTG ATGGAGATCA ACACCAGCGG GACTTTCCTC 
ACACAAGCGC TCAACCACAT GTACAAACTC CGCACGAACC TCCAGCCTCT GGAGAGTACT 
CAGTCTCAGG ACTTCTAG

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_057179.1
CDS	85..642
Translation	MDAAEVEFLAEKELVTIIPNFSLDKIYLIGGDLGPFNPGLPVEVPLWLAINLKQRQKCRLLPPEWMDVEKLEKMRDHERKEETFTPMPSPYYMELTKLLLNHASDNIPKADEIRTLVKDMWDTRIAKLRVSADSFVRQQEAHAKLDNLTLMEINTSGTFLTQALNHMYKLRTNLQPLESTQSQDF

Target ORF information:

RefSeq Version	NM_016095.2
Organism	Homo sapiens(human)
Definition	Homo sapiens GINS complex subunit 2 (GINS2), mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_016095.2

ORF Insert Sequence:

ATGGACGCTG CCGAGGTCGA ATTCCTCGCC GAGAAGGAGC TGGTTACCAT TATCCCCAAC 
TTCAGTCTGG ACAAGATCTA CCTCATCGGG GGGGACCTGG GGCCTTTTAA CCCTGGTTTA 
CCCGTGGAAG TGCCCCTGTG GCTGGCGATT AACCTGAAAC AAAGACAGAA ATGTCGCCTG 
CTCCCTCCAG AGTGGATGGA TGTAGAAAAG TTGGAGAAGA TGAGGGATCA TGAACGAAAG 
GAAGAAACTT TTACCCCAAT GCCCAGCCCT TACTACATGG AACTTACGAA GCTCCTGTTA 
AATCATGCTT CAGACAACAT CCCGAAGGCA GACGAAATCC GGACCCTGGT CAAGGATATG 
TGGGACACTC GTATAGCCAA ACTCCGAGTG TCTGCTGACA GCTTTGTGAG ACAGCAGGAG 
GCACATGCCA AGCTGGATAA CTTGACCTTG ATGGAGATCA ACACCAGCGG GACTTTCCTC 
ACACAAGCGC TCAACCACAT GTACAAACTC CGCACGAACC TCCAGCCTCT GGAGAGTACT 
CAGTCTCAGG ACTTCTAG

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

PubMed

GINS2 is a novel prognostic biomarker and promotes tumor progression in early-stage cervical cancer.
Oncology reports37(5)2652-2662(2017 May)
Ouyang F,Liu J,Xia M,Lin C,Wu X,Ye L,Song L,Li J,Wang J,Guo P,He M

New insights into the GINS complex explain the controversy between existing structural models.
Scientific reports740188(2017 Jan)
Carroni M,De March M,Medagli B,Krastanova I,Taylor IA,Amenitsch H,Araki H,Pisani FM,Patwardhan A,Onesti S

GINS2 regulates matrix metallopeptidase 9 expression and cancer stem cell property in human triple negative Breast cancer.
Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie841568-1574(2016 Dec)
Peng L,Song Z,Chen D,Linghu R,Wang Y,Zhang X,Kou X,Yang J,Jiao S

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GINS2 cDNA ORF clone, Homo sapiens(human)

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gRNAs

Related articles in PubMed

Target ORF information:

Target ORF information:

ORF Insert Sequence:

Target ORF information:

Target ORF information:

ORF Insert Sequence:

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